CN1709359A - Tablet for treating women's pelvic inflammation and its preparing method - Google Patents

Tablet for treating women's pelvic inflammation and its preparing method Download PDF

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Publication number
CN1709359A
CN1709359A CN 200510031742 CN200510031742A CN1709359A CN 1709359 A CN1709359 A CN 1709359A CN 200510031742 CN200510031742 CN 200510031742 CN 200510031742 A CN200510031742 A CN 200510031742A CN 1709359 A CN1709359 A CN 1709359A
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radix
gained
rhizoma
time
adds
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黄开启
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Abstract

The present invention relates to a Chinese medicine tablet preparation-Fuyanshu Pian for curing woman pelvic inflammation. Said Chinese medicine tablet preparation is made up by using 11 Chinese medicinal materials of lonicera stem and leaf, sargentodoxa stem, licorice, isatis leaf, dandelion, red peony root, salvia root and others. Besides, said invention provides the concrete steps of its preparation process.

Description

A kind of tablet for the treatment of pelvic inflammatory disease and preparation method thereof
Technical field:
The present invention relates to a kind of Chinese medicinal tablet and preparation technology's method thereof, relate in particular to a kind of tablet for the treatment of pelvic inflammatory disease and preparation method thereof.
Background technology:
Tablet is a kind of pharmaceutical dosage form commonly used, according to the relevant laws and regulations of China's drug control, changes dosage form and manages as new drug research.The original dosage form of this product is a capsule, has listed the national drug standards in.
The scorching relieving capsule of the woman of existing treatment pelvic inflammatory disease is that Main Ingredients and Appearance is the Chinese medicinal capsule agent of Caulis Lonicerae, Caulis Sargentodoxae, Radix Glycyrrhizae, Folium Isatidis, Herba Taraxaci, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei (system), Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system), it is with part pulverizing medicinal materials in the prescription, all the other medicinal material extract, concentrated back add aforementioned medical material fine powder mixing, drying, pulverizing, granulation, drying, pulverize, incapsulate, that is, the scorching relieving capsule of woman is used for the treatment of pelvic inflammatory disease.
The medicine stability of the scorching relieving capsule of existing woman is poor, and the production cost height is produced, preserves, carried and uses not as tablet.
Summary of the invention:
The purpose of this invention is to provide and a kind ofly can guarantee stability of drug better, reduce production costs, be beneficial to production, preserve, carry and use, be used for the treatment of the profuse leukorrhea that pelvic inflammatory disease causes, Chinese medicine preparation that stomachache etc. are sick and preparation method thereof, overcome the above-mentioned drawback of prior art, improve the quality and the curative effect of product, satisfy the needs of medical treatment better.
Technical solution of the present invention is a kind of FUYANSHU PIAN, it is a kind of Chinese patent medicine that is mainly used in the treatment pelvic inflammatory disease, medicine constituent be Caulis Lonicerae, Caulis Sargentodoxae each 20~25%, Radix Glycyrrhizae, Folium Isatidis each 1~4%, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system) each 5~10%, the tablet of Radix Et Rhizoma Rhei (system) 3~6%.
The optimum weight percentage ratio of medicine constituent is: Caulis Lonicerae, Caulis Sargentodoxae each 23.82%, Radix Glycyrrhizae, Folium Isatidis each 2.38%, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system) respectively 7.14%, Radix Et Rhizoma Rhei (system) 4.76%.
The preparation method of FUYANSHU PIAN:
(1) get it filled thing constituent and percentage by weight thereof is: Caulis Lonicerae, Caulis Sargentodoxae each 20~25%, Radix Glycyrrhizae, Folium Isatidis each 1~4%, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system) respectively 5~10%, Radix Et Rhizoma Rhei (system) 3~6%;
(2) in the medicine of (1), get the fine powder that Rhizoma Corydalis (system) was ground into 40~200 mesh sieves, sieve, standby, the best was the fine powder of 80~120 mesh sieves;
(3) in the medicine of (1), getting Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati is solvent heating and refluxing extraction 1~3 time with ethanol, adds ethanol at every turn and be 3~15 times of medical material amount, heating and refluxing extraction each 1~3 hour; Optimised process adds 8 times of amounts for the first time for adding alcohol reflux 2 times, adds 6 times of amounts for the second time, extracts 2 hours at every turn;
(4) extracting solution with multiple extraction gained in (3) merges, and filters;
(5) behind the filtrate elder generation recovery ethanol with (4) gained, being evaporated to relative density is the thick paste of 1.10~1.40 (60~70 ℃); Best for being concentrated into the thick paste that relative density is 1.36 (60 ℃);
(6) with seven flavors such as all the other Caulis Loniceraes in gained medicinal residues behind above-mentioned (3) ethanol extraction and (1), decoct with water and extract 1~5 time, add the water of 4~20 times of amounts at every turn, decocted each 1~3 hour; Optimised process is for decocting with water 3 times, adds 10 times of water gagings the 1st time to decoct 2 hours, adds 8 times of water gagings the 2nd time to decoct 1.5 hours, adds 6 times of water gagings and decocts 1 hour for the 3rd time;
(7) decocting liquid that repeatedly decocts gained in (6) is merged, filter;
(8) with the filtrate of (7) gained, being evaporated to relative density is the thick paste of 1.10~1.40 (60~70 ℃); Best for being concentrated into the thick paste that relative density is 1.36 (60 ℃);
(9) thick paste of above-mentioned (5), (8) gained is merged, add mix homogeneously in (2) gained fine powder, directly make and be ground into fine powder behind granule or the vacuum drying and granulate again, drying, tabletting, promptly.
Specific embodiments:
The present invention further specifies as follows in conjunction with specific embodiments:
A kind of FUYANSHU PIAN, be a kind of Chinese patent medicine that is mainly used in the treatment pelvic inflammatory disease, it is that constituent is the tablet of Caulis Lonicerae, each 20-25% of Caulis Sargentodoxae, Radix Glycyrrhizae, each 1-4% of Folium Isatidis, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), each 5-10% of Rhizoma Corydalis (system), Radix Et Rhizoma Rhei (system) 3-6%.
A kind of optimum implementation of FUYANSHU PIAN preparation method:
(1) get it filled thing constituent and optimum weight percentage ratio thereof is: Caulis Lonicerae, Caulis Sargentodoxae each 23.82%, Radix Glycyrrhizae, Folium Isatidis each 2.38%, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system) each 7.14%, Radix Et Rhizoma Rhei (system) 4.76%;
(2) in the above medicine, get the fine powder that Rhizoma Corydalis (system) was ground into 80~120 mesh sieves, standby.Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati add alcohol reflux 2 times, add 8 times of amounts for the first time, add 6 times of amounts for the second time, extract 2 hours at every turn, and merge extractive liquid, filters, and filtrate recycling ethanol also is evaporated to the thick paste that relative density is 1.36 (60 ℃).Medicinal residues and remaining Caulis Lonicerae etc. seven flavor decocts with water 3 times, adds 10 times of water gagings and decocts 2 hours for the 1st time, add 8 times of water gagings for the 2nd time and decocted 1.5 hours, add 6 times of water gagings and decocted collecting decoction 1 hour for the 3rd time, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.36 (60 ℃), with above-mentioned thick paste and Rhizoma Corydalis fine powder mix homogeneously, vacuum drying, be ground into fine powder, make granule, drying, tabletting, promptly.
Advantage of the present invention is: this product can guarantee to reduce production costs stability of drug better, is beneficial to production, preserves, carries and uses, and is used for the treatment of the profuse leukorrhea that pelvic inflammatory disease etc. causes, condition of disease such as stomachache satisfy the clinical treatment needs better.

Claims (3)

1, a kind of FUYANSHU PIAN, it is a kind of Chinese patent medicine that is mainly used in the treatment pelvic inflammatory disease, it is characterized in that medicine constituent and percentage by weight thereof are: Caulis Lonicerae, Caulis Sargentodoxae each 20~25%, Radix Glycyrrhizae, Folium Isatidis each 1~4%, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system) each 5~10%, the tablet of Radix Et Rhizoma Rhei (system) 3~6%.
2, a kind of preparation method of FUYANSHU PIAN is characterized in that:
(1) get it filled thing constituent and percentage by weight thereof is: Caulis Lonicerae, Caulis Sargentodoxae each 20~25%, Radix Glycyrrhizae, Folium Isatidis each 1~4%, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system) respectively 5~10%, Radix Et Rhizoma Rhei (system) 3~6%;
(2) in the medicine of (1), get the fine powder that Rhizoma Corydalis (system) was ground into 40~200 mesh sieves, sieve, standby, the best was the fine powder of 80~120 mesh sieves;
(3) in the medicine of (1), getting Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Rhizoma Polygoni Cuspidati is solvent heating and refluxing extraction 1~3 time with ethanol, adds ethanol at every turn and be 3~15 times of medical material amount, heating and refluxing extraction each 1~3 hour; Optimised process adds 8 times of amounts for the first time for adding alcohol reflux 2 times, adds 6 times of amounts for the second time, extracts 2 hours at every turn;
(4) extracting solution with multiple extraction gained in (3) merges, and filters;
(5) behind the filtrate elder generation recovery ethanol with (4) gained, being evaporated to relative density is the thick paste of 1.10~1.40 (60~70 ℃); Best for being concentrated into the thick paste that relative density is 1.36 (60 ℃);
(6) with seven flavors such as all the other Caulis Loniceraes in gained medicinal residues behind above-mentioned (3) ethanol extraction and (1), decoct with water and extract 1~5 time, add the water of 4~20 times of amounts at every turn, decocted each 1~3 hour; Optimised process is for decocting with water 3 times, adds 10 times of water gagings the 1st time to decoct 2 hours, adds 8 times of water gagings the 2nd time to decoct 1.5 hours, adds 6 times of water gagings and decocts 1 hour for the 3rd time;
(7) decocting liquid that repeatedly decocts gained in (6) is merged, filter;
(8) with the filtrate of (7) gained, being evaporated to relative density is the thick paste of 1.10~1.40 (60~70 ℃); Best for being concentrated into the thick paste that relative density is 1.36 (60 ℃);
(9) thick paste of above-mentioned (5), (8) gained is merged, add mix homogeneously in (2) gained fine powder, directly make and be ground into fine powder behind granule or the vacuum drying and granulate again, drying, tabletting, promptly.
3, FUYANSHU PIAN according to claim 1, the optimum weight percentage ratio that it is characterized in that its main constituent be Caulis Lonicerae, Caulis Sargentodoxae each 23.82%, Radix Glycyrrhizae, Folium Isatidis each 2.38%, Herba Taraxaci, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Fructus Toosendan (system), Rhizoma Corydalis (system) each 7.14%, Radix Et Rhizoma Rhei (system) 4.76%.
CN 200510031742 2005-06-24 2005-06-24 Tablet for treating women's pelvic inflammation and its preparing method Pending CN1709359A (en)

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Application Number Priority Date Filing Date Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104107280A (en) * 2014-07-03 2014-10-22 赵兰 Pharmaceutical composition for treating chronic pelvic inflammation, and preparation method and application thereof
CN104906465A (en) * 2015-06-25 2015-09-16 青岛大学附属医院 Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104107280A (en) * 2014-07-03 2014-10-22 赵兰 Pharmaceutical composition for treating chronic pelvic inflammation, and preparation method and application thereof
CN104906465A (en) * 2015-06-25 2015-09-16 青岛大学附属医院 Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof

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