CN102552527B - Traditional Chinese medicine composition used for treating diabetic complications and reducing blood sugar and preparation method thereof - Google Patents
Traditional Chinese medicine composition used for treating diabetic complications and reducing blood sugar and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition used for treating diabetic complications and reducing blood sugar. The composition comprises a formula A composed of an extract of Huidouba, an extract of euonymus alatus, an extract of balsam pear, an extract of Radix Puerariae, an extract of Sophora alopecuroide and Ganoderma broken-down wall spore powder, or comprises the formula A and a formula B which is composed of an extract of haw, an extract of banksia rose, an extract of Radix Astragali, an extract of ginseng leaves, an extract of Radix Puerariae, an extract of mulberry leaves, an extract of bighead atractylodes rhizome, an extract of Chinese angelica, an extract of Ligusticum wallichii, an extract of caulis polygoni multiflori, an extract of eucommia leaves, an extract of raw rehmannia root, an extract of epimeddium and chitosan oligosaccharide. Furthermore, the invention also provides a preparation method for the composition. The traditional Chinese medicine composition can effectively treat the complications of insomnia, gastrointestinal disorder, lower limb gangrene, ulcer, necrosis and erosion, limb numbness and pruritus, blurred vision, oral ulcer and the like caused by diabetes and can effectively reduce blood sugar.
Description
Technical field
What the present invention relates to is a kind of medicine for the treatment of diabetic complication, refers to that specifically a kind of is the medicine and preparation method thereof of raw material treatment diabetic complication and blood sugar lowering with Chinese herbal medicine.
Background technology
Diabetic complication is a kind of common chronic complicating diseases, is that it is quite serious that its consequence of back takes place by the pathological changes transformation of diabetes.Common diabetic complication has insomnia, and gastrointestinal function disorder, big dry stool are rare indefinite, lower limb gangrene, ulcer, downright bad rotten to the corn, and the numb pruritus of extremity, smudgy, blind, oral ulcer etc.Diabetic complication is one of principal element that causes diabetics death.
Show according to ADA (ADA) statistical data in 2010, the diabetics more than 3 years, the probability that develops complications is more than 46%; Diabetics more than 5 years, the probability that develops complications is more than 61%; Diabetics more than 10 years, the probability that develops complications is up to 98%.Therefore, the chronic complicating diseases for the treatment of diabetes should be core and the emphasis for the treatment of diabetes, lay stress in the change of blood glucose, blood pressure but have traditional treating diabetes now, and diabetic complication never is controlled effectively.
Summary of the invention
The purpose of this invention is to provide a kind of insomnia that is caused by diabetes for the treatment of, gastrointestinal function disorder, lower limb gangrene, ulcer, downright bad rotten to the corn, the numb pruritus of extremity, blurred vision, complication such as oral ulcer and Chinese medicine composition that can blood sugar lowering and preparation method thereof.
Realize that technical scheme of the present invention is as follows: the Chinese medicine composition for the treatment of diabetic complication and blood sugar lowering, described medicine comprises the prescription A that is made up of HUIDOUBA extract, Ramulus euonymi extract, Fructus Momordicae charantiae extract, Radix Puerariae extract, Herba Sophorae alopecuroidis extract and Sporoderm-broken Ganoderma Lucidum Spore powder.
Further, described prescription A is made of the component of following weight portion: 3～5 parts of HUIDOUBA extracts, 4～6 parts of Ramulus euonymi extracts, 2～4 parts of Fructus Momordicae charantiae extracts, 4～6 parts of Radix Puerariae extracts, 1～3 part of Herba Sophorae alopecuroidis extract, 7～9 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
Further, described prescription A is made of the component of following weight portion: 4 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 3 parts of Fructus Momordicae charantiae extracts, 5 parts of Radix Puerariae extracts, 2 parts of Herba Sophorae alopecuroidis extracts, 8 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
In order better to realize the present invention, described medicine also comprises prescription B composed of the following components:
Fructus Crataegi extract, Radix Aucklandiae extract, Radix Astragali extract, extract of Radix Ginseng leaf, Radix Puerariae extract, Folium Mori extract, Rhizoma Atractylodis Macrocephalae extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Caulis Polygoni Multiflori extract, Folium Eucommiae extract, Radix Rehmanniae extract, Herba Epimedii extract, oligochitosan.
Further, described prescription B is made of the component of following weight portion:
45～55 parts of Fructus Crataegi extracts, 17～23 parts of Radix Aucklandiae extracts, 17～23 parts of Radix Astragali extracts, 4～8 parts of extract of Radix Ginseng leafs, 8～12 parts of Radix Puerariae extracts, 8～12 parts of Folium Mori extracts, 8～12 parts of Rhizoma Atractylodis Macrocephalae extracts, 3～5 parts of Radix Angelicae Sinensis extracts, 3～5 parts of Rhizoma Chuanxiong extracts, 8～12 parts of Caulis Polygoni Multiflori extract, 8～12 parts of Folium Eucommiae extracts, 8～12 parts of Radix Rehmanniae extract, 4～8 parts of Herba Epimedii extracts, 8～12 parts of oligochitosans.
Further, described prescription B is made of the component of following weight portion:
50 parts of Fructus Crataegi extracts, 20 parts of Radix Aucklandiae extracts, 20 parts of Radix Astragali extracts, 6 parts of extract of Radix Ginseng leafs, 10 parts of Radix Puerariae extracts, 10 parts of Folium Mori extracts, 10 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Angelicae Sinensis extracts, 4 parts of Rhizoma Chuanxiong extracts, 10 parts of Caulis Polygoni Multiflori extract, 10 parts of Folium Eucommiae extracts, 10 parts of Radix Rehmanniae extract, 6 parts of Herba Epimedii extracts, 10 parts of oligochitosans.
The preparation method of the Chinese medicine composition of above-mentioned treatment diabetic complication and blood sugar lowering may further comprise the steps:
(1) preparation process of prescription A: by weight mix homogeneously, general ball is made the ball shape with each component among the prescription A;
(2) with each component among the prescription B by weight mix homogeneously, be in harmonious proportion refining with 50 degree jowar wines, make ball shape or granule.
The present invention has the following advantages and beneficial effect:
1, prescription A of the present invention can effectively treat the complication that is caused by diabetes and have the effect of blood sugar lowering, and the complication of this treatment has: insomnia, gastrointestinal function disorder, lower limb gangrene, ulcer, downright bad rotten to the corn, the numb pruritus of extremity, blurred vision, oral ulcer etc.;
2, prescription A of the present invention and prescription B are used, and not only have the effect for the treatment of diabetic complication, but also can better assist the blood glucose that reduces diabetics, make its hypoglycemic activity more obvious;
3, the component that prescription A adopts among the present invention is less, and its average price is cheap relatively, is suitable for promoting;
4, production cost of the present invention is low, obvious effective rate is high, is fit to apply.
The specific embodiment
Chinese medicine is to be extracted by the pure natural medicinal plants to form, and Chinese medicine is particular about steady blood sugar lowering, improves islet secretion, regulates functions such as body immunity, to preventing diabetic complication better curative effect is arranged, and is almost nil to the injury of human body.
Be example with the clinical experiment below, the present invention is described in further detail, but embodiments of the present invention be not limited thereto.
Embodiment 1
At first, obtain the extract of various materials, extraction step is as follows:
(1) will need the material that extracts to remove impurity; As the HUIDOUBA extract, the medicinal part of HUIDOUBA is taken out;
(2) HUIDOUBA that will remove impurity is carried out pulverization process; Namely handle by pulverizer, it is crushed to 20 orders;
(3) ratio in 1Kg HUIDOUBA and 10L water is put in it in extraction pot, refluxes 20～30 minutes, obtains extracting solution; Extracting temperature is 100 ℃;
(4) with extracting solution suction concentration tank, concentrate this extracting solution, namely adopt the conventional method for concentration of the field of Chinese medicines under 90 ℃ of left and right sides conditions, to concentrate this extracting solution;
(5) the spray-dried HUIDOUBA extract that namely makes of extracting solution after described the concentrating.
Ramulus euonymi extract among the prescription A, Fructus Momordicae charantiae extract, Radix Puerariae extract, Herba Sophorae alopecuroidis extract all obtain by above method.
Secondly, the Sporoderm-broken Ganoderma Lucidum Spore powder among the prescription A is pulverized; Be crushed to its fineness smaller or equal to 80 orders.Can cross 80 purposes sieve herein when pulverizing, just be sifted out smaller or equal to 80 purpose components, all the other compositions are proceeded to pulverize.
At last, with 4 parts of the HUIDOUBA extracts among the prescription A, 5 parts of Ramulus euonymi extracts, 3 parts of Fructus Momordicae charantiae extracts, 5 parts of Radix Puerariae extracts, 2 parts of Herba Sophorae alopecuroidis extracts, 8 parts of mix homogeneously of Sporoderm-broken Ganoderma Lucidum Spore powder, general ball makes the pill that diameter is 4mm.
Embodiment 2
Present embodiment only is that with the difference of embodiment 1 weight portion of prescription A is different.
Wherein, 3 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 4 parts of Fructus Momordicae charantiae extracts, 4 parts of Radix Puerariae extracts, 3 parts of Herba Sophorae alopecuroidis extracts, 7 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
The instructions of taking of embodiment 1 and embodiment 2 is as follows:
Get the pill 5～10g that makes according to prescription A, use warm boiled water, every day three times, take more than 3 months.
The detection method of embodiment 1 and embodiment 2 is as follows:
Select 128 and have insomnia, gastrointestinal function disorder, lower limb gangrene, ulcer, downright bad rotten to the corn, the numb pruritus of extremity, blurred vision, the diabetic complication patient of complication symptoms such as oral ulcer.Product 5～the 10g that allows the patient take to make according to above embodiment, took 3 months at every day three times.Concrete consumption when taking is determined according to patient's situation.
Testing result is as follows: the obvious effective rate for the treatment of complication reaches 47%, and total effective rate reaches 78%.The obvious effective rate of blood sugar lowering reaches 20%, and total effective rate reaches 43%.
Embodiment 3
The difference of present embodiment and embodiment 1 only is to increase when taking prescription A takes prescription B.
Described prescription B is made of following substances in parts by weight: 50 parts of Fructus Crataegi extracts, 20 parts of Radix Aucklandiae extracts, 20 parts of Radix Astragali extracts, 6 parts of extract of Radix Ginseng leafs, 10 parts of Radix Puerariae extracts, 10 parts of Folium Mori extracts, 10 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Angelicae Sinensis extracts, 4 parts of Rhizoma Chuanxiong extracts, 10 parts of Caulis Polygoni Multiflori extract, 10 parts of Folium Eucommiae extracts, 10 parts of Radix Rehmanniae extract, 6 parts of Herba Epimedii extracts, 10 parts of oligochitosans.
The preparation process of prescription B is as follows:
The extraction step of extract is identical with the extraction step of extract among the embodiment 1 among the prescription B.Oligochitosan among the prescription B is crushed to its fineness smaller or equal to 80 orders.
Various treated material among the prescription B according to above weight portion mix homogeneously, with 50 degree jowar wines mediation refinings, is made ball shape or granule.Make the ball shape of the every ball of 3g in the present embodiment.
Embodiment 4
Present embodiment only is that with the difference of embodiment 3 weight portion of prescription A and prescription B is different.
Prescription A: 3 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 4 parts of Fructus Momordicae charantiae extracts, 4 parts of Radix Puerariae extracts, 3 parts of Herba Sophorae alopecuroidis extracts, 7 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
Prescription B: 53 parts of Fructus Crataegi extracts, 23 parts of Radix Aucklandiae extracts, 17 parts of Radix Astragali extracts, 4 parts of extract of Radix Ginseng leafs, 9 parts of Radix Puerariae extracts, 9 parts of Folium Mori extracts, 11 parts of Rhizoma Atractylodis Macrocephalae extracts, 3 parts of Radix Angelicae Sinensis extracts, 5 parts of Rhizoma Chuanxiong extracts, 8 parts of Caulis Polygoni Multiflori extract, 9 parts of Folium Eucommiae extracts, 12 parts of Radix Rehmanniae extract, 5 parts of Herba Epimedii extracts, 11 parts of oligochitosans.
The instructions of taking of embodiment 3 and embodiment 4 is as follows:
3～5 of the pills of getting pill 5～10g of making according to prescription A, making according to prescription B.3～5 of pills that prescription B is made brew with eliminating cold for resuscitation water, cooperate with the prescription A of 5～10g and take, and every day three times, take more than 3 months.
The detection method of embodiment 3 and embodiment 4 is as follows:
Select 176 diabetic complication patients, as: the insomnia that is caused by diabetes had, gastrointestinal function disorder, lower limb gangrene, ulcer, downright bad rotten to the corn, the numb pruritus of extremity, blurred vision, the patient of symptoms such as oral ulcer.Make above patient take the product that makes according to the present invention.Taking dose is: the pill 5～10g that makes according to prescription A, 3～5 of the pills that makes according to prescription B.At first 3～5 of the pills that prescription B is made are used the eliminating cold for resuscitation broken off by water flush, cook tea and drink, and the while is used with pill 5～10g that prescription A makes, and every day three times, takes 3 months.Concrete consumption when taking is determined according to patient's situation.
Its testing result is: the obvious effective rate for the treatment of complication reaches 50%, and total effective rate reaches 83%.The obvious effective rate of blood sugar lowering reaches 61%, and total effective rate reaches 92%.
Show according to above testing result: prescription A of the present invention can effectively treat diabetic complication, and has effect preferably; It can also play the effect of certain blood sugar lowering.Prescription A and prescription B are used, and have strengthened the effect of its treatment complication greatly, greatly reduce blood glucose, and the effective therapeutic efficiency of diabetic complication is also increased greatly.
Just can realize the present invention preferably according to above embodiment, but embodiments of the present invention are not limited thereto.
Claims (6)
1. treat the Chinese medicine composition of diabetic complication and blood sugar lowering, it is characterized in that described Chinese medicine composition is made of the component of following weight portion: 3～5 parts of HUIDOUBA extracts, 4～6 parts of Ramulus euonymi extracts, 2～4 parts of Fructus Momordicae charantiae extracts, 4～6 parts of Radix Puerariae extracts, 1～3 part of Herba Sophorae alopecuroidis extract, 7～9 parts of Sporoderm-broken Ganoderma Lucidum Spore powder; The extract of above-mentioned each material all is to adopt water to extract and get as solvent.
2. the Chinese medicine composition for the treatment of diabetic complication according to claim 1 and blood sugar lowering, it is characterized in that described Chinese medicine composition is made of the component of following weight portion: 4 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 3 parts of Fructus Momordicae charantiae extracts, 5 parts of Radix Puerariae extracts, 2 parts of Herba Sophorae alopecuroidis extracts, 8 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
3. treat the Chinese medicine composition of diabetic complication and blood sugar lowering, it is characterized in that, described Chinese medicine composition is made up of prescription A and prescription B, and this prescription A is made of the component of following weight portion: 3～5 parts of HUIDOUBA extracts, 4～6 parts of Ramulus euonymi extracts, 2～4 parts of Fructus Momordicae charantiae extracts, 4～6 parts of Radix Puerariae extracts, 1～3 part of Herba Sophorae alopecuroidis extract, 7～9 parts of Sporoderm-broken Ganoderma Lucidum Spore powder; This prescription B is made of the component of following weight portion: 45～55 parts of Fructus Crataegi extracts, 17～23 parts of Radix Aucklandiae extracts, 17～23 parts of Radix Astragali extracts, 4～8 parts of extract of Radix Ginseng leafs, 8～12 parts of Radix Puerariae extracts, 8～12 parts of Folium Mori extracts, 8～12 parts of Rhizoma Atractylodis Macrocephalae extracts, 3～5 parts of Radix Angelicae Sinensis extracts, 3～5 parts of Rhizoma Chuanxiong extracts, 8～12 parts of Caulis Polygoni Multiflori extract, 8～12 parts of Folium Eucommiae extracts, 8～12 parts of Radix Rehmanniae extract, 4～8 parts of Herba Epimedii extracts, 8～12 parts of oligochitosans; The extract of above-mentioned each material all is to adopt water to extract and get as solvent.
4. the Chinese medicine composition for the treatment of diabetic complication according to claim 3 and blood sugar lowering, it is characterized in that described prescription A is made of the component of following weight portion: 4 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 3 parts of Fructus Momordicae charantiae extracts, 5 parts of Radix Puerariae extracts, 2 parts of Herba Sophorae alopecuroidis extracts, 8 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
5. the Chinese medicine composition for the treatment of diabetic complication according to claim 4 and blood sugar lowering, it is characterized in that described prescription B is made of the component of following weight portion: 50 parts of Fructus Crataegi extracts, 20 parts of Radix Aucklandiae extracts, 20 parts of Radix Astragali extracts, 6 parts of extract of Radix Ginseng leafs, 10 parts of Radix Puerariae extracts, 10 parts of Folium Mori extracts, 10 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Angelicae Sinensis extracts, 4 parts of Rhizoma Chuanxiong extracts, 10 parts of Caulis Polygoni Multiflori extract, 10 parts of Folium Eucommiae extracts, 10 parts of Radix Rehmanniae extract, 6 parts of Herba Epimedii extracts, 10 parts of oligochitosans.
6. the preparation method of the Chinese medicine composition of any described treatment diabetic complication of claim 3～5 and blood sugar lowering is characterized in that, may further comprise the steps:
(1) preparation process of prescription A: by weight mix homogeneously, general ball is made the ball shape with each component among the prescription A;
(2) with each component among the prescription B by weight mix homogeneously, be in harmonious proportion refining with 50 degree jowar wines, make ball shape or granule.
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| CN103283840A (en) * | 2013-04-23 | 2013-09-11 | 蚌埠市福淋乳业有限公司 | Balsam pear fermented mung bean milk with hypoglycemic effect |
| CN104172166B (en) * | 2014-08-18 | 2016-06-08 | 陈斌武 | A kind of health care congee suitable in type ��diabetes mellitus people puerperal and preparation method thereof |
| CN104187681B (en) * | 2014-09-18 | 2016-08-24 | 云南省农业科学院高山经济植物研究所 | A kind of reducing blood sugar and blood fat health food and preparation method thereof |
| CN107510836A (en) * | 2017-09-15 | 2017-12-26 | 李玉保 | A kind of bitter gourd polypeptide pharmaceutical composition for treating diabetic ulcer and preparation method thereof |
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| KR100195886B1 (en) * | 1996-11-01 | 1999-06-15 | 김상조 | Pharmaceutical composition for treating diabetes mellitus |
| CN1239196C (en) * | 2003-06-12 | 2006-02-01 | 刘新壮 | Nutrient healthy powder for decreasing blood sugar and resolving stagnation |
| CN100428948C (en) * | 2004-05-22 | 2008-10-29 | 刘贤英 | Chinese health-care medicine for reducing blood sugar and preventing from diabete complication and its preparation |
| CN101357156B (en) * | 2008-09-09 | 2010-10-13 | 田淑琴 | Traditional Chinese medicine for curing diabetes and preparation method thereof |
| CN101380339B (en) * | 2008-10-17 | 2010-11-10 | 扬州大学 | Extraction method of Heidouba effective constituent |
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Address after: 614200 processing and warehousing logistics park, Hongxing Industrial Zone, victory Town, Mount Emei, Leshan, Sichuan Patentee after: Mount Emei Hong Noboru medicine company limited-liability company Address before: 614200 processing and warehousing logistics park, Hongxing Industrial Zone, victory Town, Mount Emei, Leshan, Sichuan Patentee before: Emeishan TLS Pharmaceutical Co., Ltd. |
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