CN103751547A - Traditional Chinese medicinal composition for reducing blood lipid and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for reducing blood lipid and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for reducing blood lipid, which is prepared from the following raw materials in parts by weight: 15-20 parts of Panax notoginseng, 30-35 parts of Salvia miltiorrhiza, 30-35 parts of Ginkgo biloba leaf, 15-20 parts of Semen Cassiae, 25-30 parts of Radix Puerariae, 15-20 parts of Silybum marianum, 15-20 parts of Astragalus membranaceus,5-10 parts of Benincasa hispida peel, 10-15 parts of Bletilla striata, 2-6 parts of Solanum surattense, 10-15 parts of Radix Glycyrrhizae, and 5-10 parts of Herba Artemisiae Scopariae. The preparation method includes reflux-extracting with ethanol, drying, granulating and encapsulating. The traditional Chinese medicinal composition disclosed by the invention uses pure natural Chinese medicinal herbs to achieve blood lipid reducing and regulating effects by synergistic action.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of hyperlipidemia, belong to the field of Chinese medicines.
Background technology
Hyperlipidemia, is again hyperlipemia, and it refers to that the lipid metabolism in human body causes that in blood, blood fat raises extremely, or the variation of blood lipid level fat has exceeded normal range.Common hyperlipidemia variation shows as following one or more Indexes Abnormality: (1), serum total cholesterol level raise; (2), serum levels of triglyceride level raises; (3), serum High Density Lipoprotein Cholesterol horizontal abnormality lowers.In fact, with serum low-density LP cholesterol, replace serum total cholesterol more more accurate because the rough reflection of total cholesterol level fat the aggregate level of all lipoproteins.
The formation of hyperlipidemia is because visceral dysfunction class excretory system is disorderly.Diet aspect, the fat content of absorption is high, and the activity of human body is little, immunologic hypofunction, does not decompose normally and excretion the systemic fat of body, thereby causes unnecessary storage of fat at liver, liver is born burdens, finally form the various complication such as fatty liver.In addition 40% hyperlipemic patients also can cause hyperlipemia, and fatty liver all can occur hypolipoproteinemia, and obesity can cause that glycerol content increases, and cholesterolemia increases.The change of the caused hormone of variation (as insulin, thyroxine, adrenocortical hormone etc.) of physiology and pathology and metabolism extremely all can cause hyperlipemia.
By clinical practice, fact proved, hyperlipidemia is the prelude of cardiovascular and cerebrovascular disease, is the risk factor that causes coronary heart disease, arteriosclerosis, apoplexy, hemiplegia, is that the chief-criminal who causes cardiovascular and cerebrovascular disease brings disaster upon hands.Blood fat mainly refers to cholesterol and the triglyceride in serum.No matter be that cholesterol level increases, or the increased content of triglyceride, or both all increase, and are referred to as hyperlipemia.Investigation demonstration, hyperlipidemia has become the commonly encountered diseases of middle-aged and elderly people, and the various cardiovascular and cerebrovascular disease that cause have thus become the main chief culprit who threatens middle-aged and elderly people life
At present conventional lipid lowerers is monistic treatment clinically.The cholesterol reducing having, the careless medication of a triglyceride reducing having not only can not be played therapeutical effect, delays on the contrary treatment, finally bring out coronary heart disease, arteriosclerosis and cardiovascular and cerebrovascular disease, hyperlipidemia is most important be not simple blood fat reducing but conditioning blood fat, finally reach healing object.
Summary of the invention
The object of the invention is to overcome the deficiency of existing treatment, and a kind of Chinese medicine composition for the treatment of hyperlipidemia is provided, all select natural Chinese medicinal herb, can effectively treat hyperlipidemia.
The present invention is achieved by the following scheme: a kind of Chinese medicine composition of blood fat reducing, by the raw material of following weight portion, made: Radix Notoginseng 15-20 part, Radix Salviae Miltiorrhizae 30-35 part, Folium Ginkgo 30-35 part, Semen Cassiae 15-20 part, Radix Puerariae 25-30 part, Herba Silybi mariani 15-20 part, Radix Astragali 15-20 part, Exocarpium Benincasae 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 part, fourth eggplant 2-6 part, Radix Glycyrrhizae 10-15 part, Herba Artemisiae Scopariae 5-10 part.
Preferably, by the raw material of following weight portion, made: Radix Notoginseng 17-19 part, Radix Salviae Miltiorrhizae 31-33 part, Folium Ginkgo 32-34 part, Semen Cassiae 16-18 part, Radix Puerariae 27-29 part, Herba Silybi mariani 16-18 part, Radix Astragali 17-19 part, Exocarpium Benincasae 7-9 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 12-14 part, fourth eggplant 3-5 part, Radix Glycyrrhizae 11-13 part, Herba Artemisiae Scopariae 6-8 part.
Preferably, by the raw material of following weight portion, made: 18 parts of Radix Notoginseng, 32 parts of Radix Salviae Miltiorrhizaes, 33 parts of Folium Ginkgos, 17 parts of Semen Cassiaes, 28 parts of Radix Puerariaes, 17 parts of Herba Silybi marianis, 18 parts of the Radixs Astragali, 8 parts of Exocarpium Benincasaes, 13 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 4 parts of fourth eggplants, 12 parts, Radix Glycyrrhizae, 7 parts of Herba Artemisiae Scopariaes.
4, according to the preparation method of the arbitrary described a kind of hypoglycemic Chinese medicine composition of claim 1-3: it is characterized in that comprising following process steps: Radix Notoginseng, Radix Salviae Miltiorrhizae, Folium Ginkgo, Semen Cassiae, Radix Puerariae, Herba Silybi mariani, Radix Astragali part, Exocarpium Benincasae, the Pseudobulbus Bletillae (Rhizoma Bletillae), fourth eggplant, Radix Glycyrrhizae, the Herba Artemisiae Scopariae of getting each weight portion by proportion relation; Add mass percent 70% ethanol and soak 30 minutes at 60～65 ℃, reflux, extract, 2-3 time, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 60-100 ℃ of spraying, be ground into 80-100 object fine powder, conventional tabletting or encapsulated after granulating, obtains.
Radix Notoginseng Panax notoginseng (Burk.) F.H.Chen ex C.Chow
Meridian distribution of property and flavor: sweet micro-hardship, temperature.Enter liver, stomach, large intestine channel.
Function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, has blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.
Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bunge
Meridian distribution of property and flavor: hardship, is slightly cold.Enter the heart, Liver Channel.
Function cures mainly: have promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, with all worries set aside, blood sugar lowering and the effect such as antibacterial reduce blood pressure, calm the nerves, to menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris have certain curative effect.In addition, modern medicine experiment showed, that Radix Salviae Miltiorrhizae also has the function of anti-platelet aggregation, reduction blood viscosity and the inside and outside blood coagulation system of adjusting, is that a kind of safety is treated again the natural Chinese medicine of cardiovascular disease reliably.
Folium Ginkgo Ginkgo biloba
Meridian distribution of property and flavor: micro-hardship, property is flat.GUIXIN, lung meridian.
Function cures mainly: astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, has certain probability to improve memory.Though Folium Ginkgo energy blood circulation promoting, prevention cardiovascular diseases, but can not take other simultaneously and control cardiovascular drugs (for example aspirin), Semen Ginkgo extrac is concentrated granular shape, there is very strong removing free radical and antioxidation, the synthetic collagen Proteins of flavonoid glycoside in Folium Ginkgo, aminoacid and aminoacid is improved looks to human body, and check melanin growth keeps skin gloss and elasticity to play no small effect.In addition, according to modern clinical research, to take the chronic schizophrenia that negative symptoms is main (as social withdrawal, sluggishness, the poverty of thought, the symptom such as dull), there is remarkable result, senile dementia is also had to certain effect.
Semen Cassiae Catsia tora Linn.
Meridian distribution of property and flavor: sweet, bitter, salty, be slightly cold.Return liver, large intestine channel.
Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
Radix Puerariae: Pueraria lobata
Meridian distribution of property and flavor: sweet, pungent, cool.Return spleen, stomach warp.
Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, and rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, hypertension neck pain.
Herba Silybi mariani Silybum marianum (L.) Gaertn.
Meridian distribution of property and flavor: cold in nature, bitter in the mouth.
Function cures mainly: herb is for abscess and erysipelas; Fruit and extract are for hepatopathy, the sick cholelithiasis of spleen, jaundice and chronic cough.Heat-clearing and toxic substances removing, protects the liver, function of gallbladder promoting, protects brain, anti-X ray.Liver, the scorching diseases of gallbladder such as inflammation around acute or chronic hepatitis, liver cirrhosis, fatty liver, metabolism toxic liver injury, cholelithiasis, cholangitis and hepatic duct are all had to good efficacy, can make hepatopathy patient subjective symptoms and some biochemical index as rapid improvement such as serum bilirubin, Ji Qiu Anhui, white Anhui coefficient, prothrombing, glutamate pyruvate transaminase.
Radix Astragali Astragali Radix
Meridian distribution of property and flavor: sweet in the mouth slightly warm in nature.Return lung, spleen, liver, kidney channel.
Function cures mainly: polishing consolidating superficial resistance, holder skin ulcer granulation promoting.Cure mainly the empty spontaneous perspiration of body, chronic diarrhea, proctoptosis, uterine prolapse, chronic nephritis, body is impractical swollen, chronic ulcer, open sore part disunion of a specified duration.
Exocarpium Benincasae Exocarpium Benincase
Meridian distribution of property and flavor: cool in nature, sweet in the mouth.
Function cures mainly: inducing diuresis to remove edema., oliguria with reddish urine thirsty for edema distension, dysuria, administration's heat.
Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata (Thunb.ex A.Murray) Rchb.f.
Meridian distribution of property and flavor: bitter in the mouth, sweet, puckery, cold in nature, return lung, stomach.Liver Channel.
Function cures mainly: have astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald, rhagadia manus et pedis, anal fissure etc.
Fourth eggplant Solanum surattense Burm.f.
Meridian distribution of property and flavor: bitter, pungent, tepor.Poisonous.Function cures mainly: promoting blood circulation to remove blood stasis, analgesia anesthesia.Traumatic injury, lumbago, skelalgia of rheumatism, carbuncle pyogenic infections from tumour or sore, chilblain.
Radix Glycyrrhizae Glycyrrhiza uralensis Fisch.
Meridian distribution of property and flavor: sweet, flat.Enter spleen, stomach, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Artemisiae Scopariae ArtemisiacapillarisThunb
Meridian distribution of property and flavor: bitter, pungent, be slightly cold.Return spleen, stomach, liver, gallbladder meridian.
Function cures mainly: clearing away heat-damp and promoting diuresis, detoxification sore treatment.Control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies.
The invention has the beneficial effects as follows: adopt pure natural Chinese herbal medicine, all medicines share collaborative onset, not only reduce blood fat, can also regulate blood fat.
Clinical observation
1. clinical data
In July, 2013 to 2013 year JIUYUE, choosing altogether 200 routine hyperlipemic patients is treatment target, male 100 people wherein, female 100 people, average 58.5 years old, are divided into two groups of A, B, every group of each 100 people at random.
2. Therapeutic Method
A group: take XUEZHIKANG JIAONANG (specification 0.3g/ grain), 2 times/day, each 2, as reference group;
B group: take antilipemic Chinese herbal medicine preparation of the present invention (specification 0.45g/ grain), 2 times/day, each one.
Every 30 days is a course for the treatment of, 2 courses for the treatment of of all patient's drug administrations.
3. efficacy assessment standard
At drug administration before 1 day, drug administration after the 30th day and after drug administration the 60th day, detects respectively serum triglycerides (TG), cholesterol (CHOL), low density lipoprotein, LDL (LDL-C), high density lipoprotein (HDL-C) index to every group;
All indexs represent by mean ± standard deviation, and the statistical method of application t check is analyzed result, and P < 0.05 thinks tool significance.
4. therapeutic outcome is as follows:
The comparison of TG before and after table 1 liang group patient drug administration
The comparison of CHOL before and after table 2 liang group patient drug administration
The comparison of LDL-C before and after table 3 liang group patient drug administration
The comparison of HDL-C before and after table 4 liang group patient drug administration
From above table, can find out, the present invention is to reducing serum triglycerides (TG), cholesterol (CHOL), low density lipoprotein, LDL (LDL-C), and high density lipoprotein increasing (HDL-C) has positive effect.
Specific embodiment
Embodiment 1
(1) get 15 parts of Radix Notoginseng, 30 parts of Radix Salviae Miltiorrhizaes, 30 parts of Folium Ginkgos, 15 parts of Semen Cassiaes, 25 parts of Radix Puerariaes, 15 parts of Herba Silybi marianis, 15 parts of the Radixs Astragali, 5 parts of Exocarpium Benincasaes, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10 parts, Radix Glycyrrhizae, 2 parts of fourth eggplants, 5 parts of Herba Artemisiae Scopariaes standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 60 ℃, reflux, extract, 2 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 60 ℃ of sprayings, be ground into 80 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 2
Get 20 parts of Radix Notoginseng, 35 parts of Radix Salviae Miltiorrhizaes, 35 parts of Folium Ginkgos, 20 parts of Semen Cassiaes, 30 parts of Radix Puerariaes, 20 parts of Herba Silybi marianis, 20 parts of the Radixs Astragali, 10 parts of Exocarpium Benincasaes, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts, Radix Glycyrrhizae, 6 parts of fourth eggplants, 10 parts of Herba Artemisiae Scopariaes standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 100 ℃ of sprayings, be ground into 100 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 3
(1) get 17 parts of Radix Notoginseng, 31 parts of Radix Salviae Miltiorrhizaes, 32 parts of Folium Ginkgos, 16 parts of Semen Cassiaes, 27 parts of Radix Puerariaes, 16 parts of Herba Silybi marianis, 17 parts of the Radixs Astragali, 7 parts of Exocarpium Benincasaes, 12 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 11 parts, Radix Glycyrrhizae, 3 parts of fourth eggplants, 6 parts of Herba Artemisiae Scopariaes standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 70 ℃ of sprayings, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 4
(1) get 19 parts of Radix Notoginseng, 33 parts of Radix Salviae Miltiorrhizaes, 34 parts of Folium Ginkgos, 18 parts of Semen Cassiaes, 29 parts of Radix Puerariaes, 16 parts of Herba Silybi marianis, 19 parts of the Radixs Astragali, 9 parts of Exocarpium Benincasaes, 14 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 13 parts, Radix Glycyrrhizae, 5 parts of fourth eggplants, 8 parts of Herba Artemisiae Scopariaes standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 80 ℃ of sprayings, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 5
(1) get 18 parts of Radix Notoginseng, 32 parts of Radix Salviae Miltiorrhizaes, 33 parts of Folium Ginkgos, 17 parts of Semen Cassiaes, 28 parts of Radix Puerariaes, 17 parts of Herba Silybi marianis, 18 parts of the Radixs Astragali, 8 parts of Exocarpium Benincasaes, 13 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 12 parts, Radix Glycyrrhizae, 4 parts of fourth eggplants, 7 parts of Herba Artemisiae Scopariaes standby;
(2) add mass percent 70% ethanol and soak 30 minutes at 65 ℃, reflux, extract, 3 times, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 90 ℃ of sprayings, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Claims (4)
1. a Chinese medicine composition for blood fat reducing, is characterized in that being made by the raw material of following weight portion: Radix Notoginseng 15-20 part, Radix Salviae Miltiorrhizae 30-35 part, Folium Ginkgo 30-35 part, Semen Cassiae 15-20 part, Radix Puerariae 25-30 part, Herba Silybi mariani 15-20 part, Radix Astragali 15-20 part, Exocarpium Benincasae 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-15 part, fourth eggplant 2-6 part, Radix Glycyrrhizae 10-15 part, Herba Artemisiae Scopariae 5-10 part.
2. the Chinese medicine composition of a kind of blood fat reducing according to claim 1, is characterized in that being made by the raw material of following weight portion: Radix Notoginseng 17-19 part, Radix Salviae Miltiorrhizae 31-33 part, Folium Ginkgo 32-34 part, Semen Cassiae 16-18 part, Radix Puerariae 27-29 part, Herba Silybi mariani 16-18 part, Radix Astragali 17-19 part, Exocarpium Benincasae 7-9 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 12-14 part, fourth eggplant 3-5 part, Radix Glycyrrhizae 11-13 part, Herba Artemisiae Scopariae 6-8 part.
3. the Chinese medicine composition of a kind of blood fat reducing according to claim 1, is characterized in that being made by the raw material of following weight portion: 18 parts of Radix Notoginseng, 32 parts of Radix Salviae Miltiorrhizaes, 33 parts of Folium Ginkgos, 17 parts of Semen Cassiaes, 28 parts of Radix Puerariaes, 17 parts of Herba Silybi marianis, 18 parts of the Radixs Astragali, 8 parts of Exocarpium Benincasaes, 13 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 4 parts of fourth eggplants, 12 parts, Radix Glycyrrhizae, 7 parts of Herba Artemisiae Scopariaes.
4. according to the preparation method of the arbitrary described a kind of hypoglycemic Chinese medicine composition of claim 1-3: it is characterized in that comprising following process steps: Radix Notoginseng, Radix Salviae Miltiorrhizae, Folium Ginkgo, Semen Cassiae, Radix Puerariae, Herba Silybi mariani, Radix Astragali part, Exocarpium Benincasae, the Pseudobulbus Bletillae (Rhizoma Bletillae), fourth eggplant, Radix Glycyrrhizae, the Herba Artemisiae Scopariae of getting each weight portion by proportion relation; Add mass percent 70% ethanol and soak 30 minutes at 60～65 ℃, reflux, extract, 2-3 time, each 2 hours, 200 order filters filtered, and obtain extracting solution; Merge extractive liquid,, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; Concentrated solution is dried or is dried 60-100 ℃ of spraying, be ground into 80-100 object fine powder, conventional tabletting or encapsulated after granulating, obtains.
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| CN105381388A (en) * | 2015-12-21 | 2016-03-09 | 李建敏 | Traditional Chinese medicine composition for treating stomach discomfort and preparing method thereof |
| CN105396041A (en) * | 2015-12-21 | 2016-03-16 | 李建敏 | Traditional Chinese medicine composition for treating stomach cold and preparation method thereof |
| CN105395695A (en) * | 2015-12-21 | 2016-03-16 | 李建敏 | Traditional Chinese medicine composition treating stomach pain and preparation method thereof |
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