CN105250427A - Pharmaceutical composition for treating heart diseases - Google Patents
Pharmaceutical composition for treating heart diseases Download PDFInfo
- Publication number
- CN105250427A CN105250427A CN201510749067.XA CN201510749067A CN105250427A CN 105250427 A CN105250427 A CN 105250427A CN 201510749067 A CN201510749067 A CN 201510749067A CN 105250427 A CN105250427 A CN 105250427A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- parts
- radix
- pheretima
- clear paste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a pharmaceutical composition for treating heart diseases. The pharmaceutical composition is characterized by comprising the following components in parts by weight according to a prescription: 20-60 parts of astragalus, 10-30 parts of angelica sinensis, 10-30 parts of red paeony roots, 10-30 parts of ligusticum wallichii, 5-20 parts of peach kernels, 5-20 parts of safflowers and 1-15 parts of earthworms. The pharmaceutical composition provided by the invention has the effects of invigorating qi, activating blood and strengthening the heart and is simple in components, scientific and reasonable in formula and remarkable heart disease treatment effect.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition for the treatment of heart disease.
Background technology
Heart disease is the general name of heart disease, comprises the various heart diseases such as rheumatic heart disease, congenital heart disease, hypertensive heart disease, coronary heart disease, myocarditis.The number one killer of the mankind is sudden cardiac arrest (being called for short SCA).At present according to the numeral that World Health Organization (WHO) issues, the whole world, often in dead 3 people, just has 1 people to die from cardiovascular disease, China, has hundreds of thousands people to die from heart disease every year.Heart disease has very large puzzlement and threat to patient, although have in some now, western medicine mode, curative effect is all comparatively general, can not effectively alleviate heart disease preferably and treat.Therefore, develop a kind ofly to have no side effect, scientific formulation, taking convenience, treatment heart disease evident in efficacy medicine be desirable.
Summary of the invention
The Chinese medicine composition for the treatment of heart disease that the present invention aims to provide a kind of stable curative effect, has no side effect.
For achieving the above object, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, its specific embodiments is:
A kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 20-60 part, each 10-30 part of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 5-20 part of Semen Persicae, Flos Carthami, Pheretima 1-15 part.
Further, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 30-50 part, each 12-24 part of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 8-15 part of Semen Persicae, Flos Carthami, Pheretima 5-10 part.
Further, a kind of pharmaceutical composition for the treatment of heart disease of the present invention, is characterized in that this pharmaceutical composition prescription number is counted: the Radix Astragali 45 parts, each 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 10 parts of Semen Persicae, Flos Carthami, Pheretima 8 parts.
Pharmaceutical composition described in any one of the present invention, is characterized in that, described preparation is oral formulations.
Further, preparation of the present invention, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.
Further, preparation of the present invention, is characterized in that, described preparation is tablet.
Further, preparation of the present invention, is characterized in that, the preparation method of this tablet is: 1) by the recipe quantity Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Pheretima wears into coarse powder, and mixing, according to the percolation under fluid extract and extractum item, with 4-8 times amount 60% ethanol as solvent, dipping 12-18 hour, slowly percolation, collect 6 times amount and to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulate, tabletting, to obtain final product.
The each component pharmacology analysis of prescription of the present invention:
The Radix Astragali: sweet, tepor.Return lung, spleen, liver, kidney channel.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Radix Angelicae Sinensis: sweet, pungent, warm, returns liver, the heart, spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.
Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.
Rhizoma Chuanxiong: pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.
Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.
Flos Carthami: pungent, warm, GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, stimulates the menstrual flow.
Pheretima: salty, cold.Return liver, spleen, urinary bladder channel.Pheretima effect: clearing away heat and relieving the wind syndrome, relievings asthma, dredging collateral, diuresis.
Asthenia of qi and blood then should be mended, and heart blood stasis then should disappear.The pure benefit then stasis of blood is not gone, and purely disappears then just more empty, therefore controls and should mend double the executing that disappear.Reuse Radix Astragali QI invigorating in side, be equipped with Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami with blood circulation promoting and blood stasis dispelling; Pheretima expel wind to dredge collateral; Add Radix Aconiti Lateralis Preparata during postscript, Radix Ginseng provides guarantee for obtaining good therapeutic effect.All medicines share, and play the merit of benefiting QI for activating blood circulation heart tonifying altogether.
Beneficial effect of the present invention is:
1. prescription scientific formulation, evident in efficacy.
2. prescription crude drug source is wide, and technique is simple, is applicable to large-scale production, has industrialization prospect.
Detailed description of the invention
The present invention is further illustrated below for embodiment.
Embodiment 1
Prescription:
The Radix Astragali 45 parts, each 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 10 parts of Semen Persicae, Flos Carthami, Pheretima 8 parts.
Preparation technology:
1) by the recipe quantity Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Pheretima wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 6 times amount 60% ethanol as solvent, flood 15 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulate, tabletting, to obtain final product.
Embodiment 2
Prescription:
The Radix Astragali 45 parts, each 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 10 parts of Semen Persicae, Flos Carthami, Pheretima 8 parts.
Preparation technology:
1) by the recipe quantity Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Pheretima wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 8 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulate, tabletting, to obtain final product.
Embodiment 3
Prescription:
The Radix Astragali 45 parts, each 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 10 parts of Semen Persicae, Flos Carthami, Pheretima 8 parts.
Decoction preparation technology:
First, by the recipe quantity Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Pheretima medical material warm water is soaked 20 minutes (water yield of immersion is advisable to flood powder 2 ~ 3cm); Secondly, be placed on by medicine on fire, endure out with big fire, timing after boiling, decocts 60 minutes; Finally, first time fried medicinal liquid is poured out, add appropriate hot water (being advisable just to flood medical material) and carry out second time and decoct, about the about 30 minutes time of second time decoction.To mix with second time medicinal liquid by medicinal liquid for the first time, obtain decoction of the present invention.
Embodiment 4
Prescription:
The Radix Astragali 45 parts, each 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 10 parts of Semen Persicae, Flos Carthami, Pheretima 8 parts.
Capsule preparation technology:
1) by the recipe quantity Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Pheretima wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 8 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulates, filled capsules and get final product.
Embodiment 5
Prescription:
The Radix Astragali 45 parts, each 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 10 parts of Semen Persicae, Flos Carthami, Pheretima 8 parts.
Preparation Technology of Granules:
1) by the recipe quantity Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Pheretima wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 8 times amount 60% ethanol as solvent, flood 18 hours, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granule processed, to obtain final product.
Clinical application effect of the present invention:
One, physical data accepts patient's totally 10 examples for medical treatment, 48 years old mean age.
Two, Therapeutic Method is according to Medications Example one of the present invention, and tablet prepared by preferred preparation method, one day three times, each three, decoction being taken warmly.It within 15th, is a course for the treatment of.Three, therapeutic outcome statistics
Treat after 15 days, fully recover 7 people, effective 2 people, invalid 1 people, total effective rate 90%.Wherein: total effective rate=cure rate+effective percentage.It should be noted that; above-described embodiment is only preferred embodiment of the present invention; be not used for limiting protection scope of the present invention; protection scope of the present invention is as the criterion with claims; equivalent replacement done on the basis of technique scheme or substitute, all belongs to protection scope of the present invention.
Claims (7)
1. treat a pharmaceutical composition for heart disease, it is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 20-60 part, each 10-30 part of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 5-20 part of Semen Persicae, Flos Carthami, Pheretima 1-15 part.
2. a kind of pharmaceutical composition for the treatment of heart disease according to claim 1, is characterized in that this pharmaceutical composition prescription number is counted: Radix Astragali 30-50 part, each 12-24 part of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 8-15 part of Semen Persicae, Flos Carthami, Pheretima 5-10 part.
3. a kind of pharmaceutical composition for the treatment of heart disease according to claim 1, is characterized in that this pharmaceutical composition prescription number is counted: the Radix Astragali 45 parts, each 16 parts of Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, each 10 parts of Semen Persicae, Flos Carthami, Pheretima 8 parts.
4. the pharmaceutical composition according to any one of claim 1-3, is characterized in that, described preparation is oral formulations.
5. preparation according to claim 4, is characterized in that, described preparation is made up of Chinese medicine composition and pharmaceutically acceptable carrier, and dosage form comprises water decoction, pill, capsule, granule, electuary and oral liquid.
6. preparation according to claim 5, is characterized in that, described preparation is tablet.
7. preparation according to claim 6, is characterized in that, the preparation method of this tablet is: 1) by the recipe quantity Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Pheretima wears into coarse powder, mixing, according to the percolation under fluid extract and extractum item, with 4-8 times amount 60% ethanol as solvent, dipping 12-18 hour, slowly percolation, collect 6 times amount to filter liquid, decompression recycling ethanol is also concentrated into the clear paste that relative density is 1.06 ~ 1.08, leaves standstill 24 hours;
2) medicinal residues add 8 times amount soak by water 1 hour, and filter, filtrate reduced in volume to relative density is the clear paste of 1.06 ~ 1.08, leave standstill 24 hours, merge above-mentioned two kinds of clear paste, mixing, boil 30 minutes, filter while hot, filtrate reduced in volume to relative density is the clear paste of 1.30 ~ 1.32, add cane sugar powder and dextrin, granulate, 80 DEG C of dryings, let cool, mixing, granulate, tabletting, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749067.XA CN105250427A (en) | 2015-11-08 | 2015-11-08 | Pharmaceutical composition for treating heart diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510749067.XA CN105250427A (en) | 2015-11-08 | 2015-11-08 | Pharmaceutical composition for treating heart diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250427A true CN105250427A (en) | 2016-01-20 |
Family
ID=55090562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510749067.XA Pending CN105250427A (en) | 2015-11-08 | 2015-11-08 | Pharmaceutical composition for treating heart diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250427A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929392A (en) * | 2017-12-26 | 2018-04-20 | 广州中医药大学 | A kind of pharmaceutical composition, preparation method and application |
| CN115137771A (en) * | 2022-06-14 | 2022-10-04 | 广西纯正堂制药有限公司 | Thrombus eliminating tablet for treating ischemic cardiac and cerebral vascular diseases and its prepn |
| CN115463174A (en) * | 2022-09-27 | 2022-12-13 | 渭南山野士科技发展有限公司 | Pure traditional Chinese medicine preparation for tonifying qi, strengthening heart and recovering cardiac function and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114085A (en) * | 2010-06-11 | 2011-07-06 | 李银春 | Traditional Chinese medicine oral decoction for treating coronary heart disease |
-
2015
- 2015-11-08 CN CN201510749067.XA patent/CN105250427A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102114085A (en) * | 2010-06-11 | 2011-07-06 | 李银春 | Traditional Chinese medicine oral decoction for treating coronary heart disease |
Non-Patent Citations (2)
| Title |
|---|
| 温瑞书: "《王清任医方精要》", 31 January 2003, 河北科学技术出版社 * |
| 高华: "《最新国家药品标准实施手册 第2卷》", 31 March 2004, 社会科学文献出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929392A (en) * | 2017-12-26 | 2018-04-20 | 广州中医药大学 | A kind of pharmaceutical composition, preparation method and application |
| CN115137771A (en) * | 2022-06-14 | 2022-10-04 | 广西纯正堂制药有限公司 | Thrombus eliminating tablet for treating ischemic cardiac and cerebral vascular diseases and its prepn |
| CN115137771B (en) * | 2022-06-14 | 2024-05-03 | 九华华源药业(桂林)有限公司 | Thrombolytic tablet for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN115463174A (en) * | 2022-09-27 | 2022-12-13 | 渭南山野士科技发展有限公司 | Pure traditional Chinese medicine preparation for tonifying qi, strengthening heart and recovering cardiac function and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101066303B (en) | Medicine for treating cerebral thrombus, cerebral angiosclerosis, apoplexy and hemiplegia and its preparation | |
| CN103071128B (en) | Externally-applied plaster for curing dysmenorrhea | |
| CN101987138A (en) | Chinese medicinal preparation for treating impotence | |
| CN104258350A (en) | Traditional Chinese medicine preparation for treating sick sinus syndrome and preparation method of traditional Chinese medicine preparation | |
| CN102225100A (en) | Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and preparation process of products thereof | |
| CN102048899A (en) | Traditional Chinese medicine preparation for treating impotence | |
| CN105250427A (en) | Pharmaceutical composition for treating heart diseases | |
| CN103316192A (en) | Traditional Chinese medicine foot-bathing liquid for treating lumbocrural pain and preparation method thereof | |
| CN104524159A (en) | Pharmaceutical composition for treating hyperplasia of mammary glands | |
| CN101390970B (en) | Traditional Chinese medicine for treating hepatitis B and preparation method thereof | |
| CN105833011A (en) | Healthcare medicinal liquor | |
| CN105943705A (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof | |
| CN101983695A (en) | Traditional Chinese medicine composition for curing hemiplegia and preparation method thereof | |
| CN104435567A (en) | Traditional Chinese medicinal composition containing gynostemma pentaphyllum for treating gout | |
| CN101874850A (en) | Medicament for treating chronic urticaria | |
| CN103550674A (en) | Blood stasis removing and blood circulation invigorating soup | |
| CN102078531A (en) | Medicine for treating hypertension and preparation method thereof | |
| CN101912583A (en) | Medicament for treating chronic hepatitis and early-phase hepatocirrhosis and preparation method thereof | |
| CN105343688A (en) | Medicine composition for treating myocardial infarction and application thereof | |
| CN102526415B (en) | Chinese medicinal composition for treating dysmenorrhea and preparation method of same | |
| CN104623381A (en) | Traditional-Chinese-medicine composition for treating skin disease caused by blood heat and liver depression | |
| CN103494939A (en) | Traditional Chinese medicine for treating senile habitual constipation | |
| CN105194296A (en) | Medicine composition for treating heart diseases | |
| CN1175875C (en) | Medicine made of lysimachia for treating hepatobiliary calculus and its prescription | |
| CN102379982A (en) | Chinese herbal medicine for treating fire excess from yin deficiency, and steaming bone fever |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160120 |
|
| RJ01 | Rejection of invention patent application after publication |