CN103495103B - Medicament for promoting digestion and strengthening spleen - Google Patents

Abstract

The invention discloses a medicament for promoting digestion and strengthening spleen. The medicament is prepared from the following active pharmaceutical ingredients in parts by weight: 30 parts of raw membranous milkvetch root, 30 parts of common yam rhizome, 15 parts of stir-fried largehead atractylodes rhizome, 30 parts of coix seed, 15 parts of honeysuckle flower, 30 parts of Mongolian dandelion herb, 15 parts of Chinese angelica, 6 parts of honey-fried liquorice root, 20 parts of dendrobium, 15 parts of eucommia bark, 10 parts of baical skullcap root, 15 parts of himalayan teasel root, 15 parts of Indian buead, 10 parts of Indian trum etflower seed, 6 parts of liquorice root, 10 parts of cassia twig, 30 parts of hairyvein agrimonia herb and bud, 10 parts of villous amomum fruit, 15 parts of bletilla striata, 15 parts of chrysanthemum, 15 parts of white hyacinth bean, 10 parts of stir-fried malt, 15 parts of silktree albizzia bark and 10 parts of bitter orange. The medicament has unexpected effects of strengthening spleen and promoting digestion.

Description

The medicine of digestion-promoting spleen-invigorating

Technical field

The present invention relates to technical field of Chinese medicines, be specially a kind of medicine of digestion-promoting spleen-invigorating.

Background technology

Insufficiency of the spleen then dysfunction of the spleen in transportation and transformation, and can occur malnutrition, water liquid loses rawly in spreading wetly makes expectorant, or the disease such as to lose blood.Its disease is at stomach, and dyspepsia relates to the internal organs such as liver spleen, and suitable determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, gives invigorating the spleen and regulating the stomach, depressed liver-energy dispersing and QI regulating, the method treatments such as dyspepsia and intestinal stasis relieving.But western medicine side effect is comparatively large, market similar Chinese patent medicine DeGrain.

Summary of the invention

The object of the invention is, in order to overcome above-mentioned the deficiencies in the prior art part, to provide a kind of medicine of digestion-promoting spleen-invigorating according to Chinese medical theory.

The medicine of digestion-promoting spleen-invigorating of the present invention is the medicament be made up of the crude drug of following parts by weight:

Radix Astragali 30 parts, Rhizoma Dioscoreae 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Semen Coicis 30 parts, Flos Lonicerae 15 parts, Herba Taraxaci 30 parts, Radix Angelicae Sinensis 15 parts, Radix Glycyrrhizae Preparata 6 parts, Herba Dendrobii 20 parts, the Cortex Eucommiae 15 parts, Radix Scutellariae 10 parts, Radix Dipsaci 15 parts, 15 parts, Poria, Semen Oroxyli 10 parts, 6 parts, Radix Glycyrrhizae, Ramulus Cinnamomi 10 parts, Herba Agrimoniae 30 parts, Fructus Amomi 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Flos Chrysanthemi 15 parts, Fructus Aurantii 10 parts, Fructus Hordei Germinatus (parched) 10 parts, Cortex Albiziae 15 parts and Semen Lablab Album 15 parts.

Described medicament is capsule.

The preparation method of medicine of the present invention is:

Get crude drug Radix Astragali 30 parts, Rhizoma Dioscoreae 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Semen Coicis 30 parts, Flos Lonicerae 15 parts, Herba Taraxaci 30 parts, Radix Angelicae Sinensis 15 parts, Radix Glycyrrhizae Preparata 6 parts, Herba Dendrobii 20 parts, the Cortex Eucommiae 15 parts, Radix Scutellariae 10 parts, Radix Dipsaci 15 parts, 15 parts, Poria, Semen Oroxyli 10 parts, 6 parts, Radix Glycyrrhizae, Ramulus Cinnamomi 10 parts, Herba Agrimoniae 30 parts, Fructus Amomi 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Flos Chrysanthemi 15 parts, Fructus Aurantii 10 parts, Fructus Hordei Germinatus (parched) 10 parts, Cortex Albiziae 15 parts and Semen Lablab Album 15 parts by weight for subsequent use;

Second step: after being mixed by above-mentioned raw materials medicine, be dried and crushed into fine flour, cross 500 mesh sieves, incapsulate.

Digestion-promoting spleen-invigorating Chinese medicine composition provided by the invention, its raw material is Radix Astragali, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae (parched), Semen Coicis, Flos Lonicerae, Herba Taraxaci, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Herba Dendrobii, the Cortex Eucommiae, Radix Scutellariae, Radix Dipsaci, Poria, Semen Oroxyli, Fructus Hordei Germinatus (parched), Ramulus Cinnamomi, Herba Agrimoniae, Fructus Amomi, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Chrysanthemi, Fructus Aurantii, Radix Glycyrrhizae, Cortex Albiziae and Semen Lablab Album, can be used for the vomiting for the treatment of because insufficiency of the spleen and dyspepsia cause, abdominal distention and becoming thin, effect of what above-mentioned medical material had have certain digestion-promoting spleen-invigorating, the effect with certain building body had, this formula is in R&D process, with the formula in the patent of applying on the same day for core, by the additional formulations that increase and decrease flavour of a drug and adjustment compatibility relationship draw, insufficiency of the spleen in treatment, dyspepsia, vomiting, abdominal distention and the aspect such as to become thin achieve the curative effect showed, make this medicine in digestion-promoting spleen-invigorating and have no side effect to create beyond thought effect.Observed through 1 year both without recurring also without obvious toxic and side effects.

Detailed description of the invention

A medicine for digestion-promoting spleen-invigorating, be made up of following bulk drugs:

Radix Astragali 30g, Rhizoma Dioscoreae 30g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Semen Coicis 30g, Flos Lonicerae 15g, Herba Taraxaci 30g, Radix Angelicae Sinensis 15g, Radix Glycyrrhizae Preparata 6g, Herba Dendrobii 20g, Cortex Eucommiae 15g, Radix Scutellariae 10g, Radix Dipsaci 15g, Poria 15g, Semen Oroxyli 10g, Radix Glycyrrhizae 6g, Ramulus Cinnamomi 10g, Herba Agrimoniae 30g, Fructus Amomi 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Flos Chrysanthemi 15g, Fructus Aurantii 10g, Fructus Hordei Germinatus (parched) 10g, Cortex Albiziae 15g and Semen Lablab Album 10g;

Second step: after being mixed by above-mentioned raw materials medicine, be dried and crushed into fine flour, cross 500 mesh sieves, incapsulate.Every capsule has above-mentioned raw materials medicine 0.4g.

The drug effect of each taste crude drug is as follows:

1. Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.

2. Rhizoma Dioscoreae: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.

3. Rhizoma Atractylodis Macrocephalae (parched): invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.

4. Semen Coicis: spleen invigorating, eliminating dampness by diuresis, antidiarrheal, evacuation of pus.

5. Flos Lonicerae: can dispelling wind-heat, also kind removing summer-heat blood poison.

6. Herba Taraxaci: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.

7. Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

8. Radix Glycyrrhizae Preparata: spleen reinforcing stomach function regulating, Yiqi and vein recovery.

9. Herba Dendrobii: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.

10. the Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.

11. Radix Scutellariaes: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.

12. Radix Dipsacis: invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.

13. Poria: Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.

14. Semen Oroxylis: lung moistening, soothing liver-QI, stomach function regulating, granulation promoting.

15. Radix Glycyrrhizaes: QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.

16. Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation.

17. Herba Agrimoniaes: astringing to arrest bleeding, detoxification sore treatment, parasite killing, puckery antiperspirant, cough-relieving.

18. Fructus Amomis: removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.

19. Pseudobulbus Bletillae (Rhizoma Bletillae)s: tonifying the lung, relieving cough and resolving phlegm, hemostasia and promoting granulation.

20. Flos Chrysanthemis: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.

21. Fructus Aurantiis: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.

22. Semen Lablab Albums: spleen reinforcing and in, removing dampness is relieved summer heat.

23. Fructus Hordei Germinatus (parched)s: promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back newborn relieving distension.

24. Cortex Albiziaes: have resolving depression of calming the nerves, the effect of eliminating carbuncle of invigorating blood circulation.

Instructions of taking: the people of more than 18 years old three times on the one, each 1.Within 30 days, be a course for the treatment of, take three courses for the treatment of continuously.As taken 1 week symptom continuously without obviously changing or occurring that diarrhoea and vomiting increase the weight of after taking medicine, should drug withdrawal immediately, transference cure after drug withdrawal.

Clinical trial:

Choose 150 routine functional dyspepsias and with gastrointestinal upset as vomiting, abdominal distention and the Patients of Spleen Deficiency of becoming thin, age 18-50 year, the course of disease more than 3 months, did not carry out any treatment in 2 months.Above-mentioned 150 routine patients are divided into treatment group and matched group two groups, treatment group 100 example, the capsule obtained with this enforcement is treated, and three times on the oral one, each 1 30 days is a course for the treatment of, takes three courses for the treatment of continuously.Matched group 50 example, takes domperidone tablet treatment: oral, 10 ~ 20mg or suspension 10ml, every day 3 ~ 4 times, 15 ~ 30 minutes ante cibum took, and within 15 days, were a course for the treatment of, took three courses for the treatment of continuously.Then clinical observation is carried out.

Period in a medicine treatment group self clinical observation on the therapeutic effect analysis result is as follows:

Curative effect project	Treatment group number of cases	Improvement rate (%)
			Vomiting number of times reduces	88	88%
Abdominal distention is alleviated	90	90%
			Body weight increases	84	84%
Appetite increases	94	94%
			Total improvement rate (%)		89%

The clinical observation on the therapeutic effect analysis result of period in a medicine treatment group and matched group is as follows:

Efficacy assessment standard is as follows:

1, effective: vomiting is obviously controlled, and abdominal distention is obviously alleviated, body weight increases, and appetite increases, the transference cure of all the other gastrointestinal upsets.

2, take a turn for the better: vomiting number of times reduces or the intermittent time extends, and abdominal distention is alleviated to some extent, body weight stops alleviating, and appetite makes moderate progress, and the symptom partial symptoms of all the other gastrointestinal upsets disappears.

3, invalid: symptom is without improvement or increase the weight of.

The comparison sheet of the clinical medicine incidence of side effects of period in a medicine treatment group and matched group

Stomachache and Refuse to take medicine are clinical modal side effect as can be seen from the above table, but can progressively disappear after drug withdrawal.But tremble and the incidence rate of side effect of having blood in stool, take the matched group of domperidone tablet apparently higher than the treatment group taking capsule of the present invention, so the present invention does not have obvious toxic and side effects substantially.

Claims (2)

1. a medicine for digestion-promoting spleen-invigorating, is characterized in that it is the medicament be made up of the crude drug of following parts by weight:

Radix Astragali 30 parts, Rhizoma Dioscoreae 30 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Semen Coicis 30 parts, Flos Lonicerae 15 parts, Herba Taraxaci 30 parts, Radix Angelicae Sinensis 15 parts, Radix Glycyrrhizae Preparata 6 parts, Herba Dendrobii 20 parts, the Cortex Eucommiae 15 parts, Radix Scutellariae 10 parts, Radix Dipsaci 15 parts, 15 parts, Poria, Semen Oroxyli 10 parts, 6 parts, Radix Glycyrrhizae, Ramulus Cinnamomi 10 parts, Herba Agrimoniae 30 parts, Fructus Amomi 10 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Flos Chrysanthemi 15 parts, Fructus Aurantii 10 parts, Fructus Hordei Germinatus (parched) 10 parts, Cortex Albiziae 15 parts and Semen Lablab Album 15 parts.

2. the medicine of digestion-promoting spleen-invigorating according to claim 1, is characterized in that described medicament is capsule.