CN103495104A - Medicament for promoting digestion and strengthening spleen - Google Patents

Abstract

The invention discloses a medicament for promoting digestion and strengthening spleen. The medicament is prepared from the following active pharmaceutical ingredients in parts by weight: 30 parts of raw membranous milkvetch root, 30 parts of common yam rhizome, 15 parts of stir-fried largehead atractylodes rhizome, 30 parts of coix seed, 10 parts of golden thread, 30 parts of Mongolian dandelion herb, 15 parts of Chinese angelica, 6 parts of honey-fried liquorice root, 20 parts of dendrobium, 15 parts of eucommia bark, 10 parts of baical skullcap root, 15 parts of himalayan teasel root, 15 parts of Indian buead, 10 parts of Indian trum etflower seed, 6 parts of liquorice root, 10 parts of cassia twig, 30 parts of hairyvein agrimonia herb and bud, 10 parts of villous amomum fruit, 15 parts of bletilla striata, 15 parts of white paeony root, 15 parts of white hyacinth bean, 10 parts of stir-fried malt, 15 parts of silktree albizzia bark and 10 parts of bitter orange. The medicament has unexpected effects of strengthening spleen and promoting digestion.

Description

A kind of medicine of digestion-promoting spleen-invigorating

Technical field

The present invention relates to technical field of Chinese medicines, be specially a kind of medicine of digestion-promoting spleen-invigorating.

Background technology

Insufficiency of the spleen dysfunction of the spleen in transportation and transformation, and malnutrition can occur, water liquid loses in spreading and gives birth to the wet expectorant of making, or the disease such as lose blood.Its disease is at stomach, and dyspepsia relates to the internal organs such as liver spleen, and suitable determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, give invigorating the spleen and regulating the stomach, depressed liver-energy dispersing and QI regulating, the treatment of the methods such as dyspepsia and intestinal stasis relieving.But the western medicine side effect is larger, the Chinese patent medicine DeGrain that market is similar.

Summary of the invention

The objective of the invention is, in order to overcome above-mentioned the deficiencies in the prior art part, provides a kind of medicine of digestion-promoting spleen-invigorating according to Chinese medical theory.

The medicine of digestion-promoting spleen-invigorating of the present invention is the medicament of being made by the crude drug of following parts by weight:

15 parts of 30 parts of Radix Astragali, 30 parts of Rhizoma Dioscoreaes, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 30 parts of Semen Coiciss, 10 parts of Rhizoma Coptidis, 30 parts of Herba Taraxacis, 15 parts of Radix Angelicae Sinensis, 6 parts of Radix Glycyrrhizae Preparatas, 20 parts of Herba Dendrobiis, 15 parts of the Cortexs Eucommiae, 10 parts of Radix Scutellariaes, 15 parts of Radix Dipsacis, 15 parts, Poria, 10 parts of Semen Oroxylis, 6 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 30 parts of Herba Agrimoniaes, 10 parts of Fructus Amomis, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of the Radix Paeoniae Albas, 10 parts of Fructus Aurantiis, 10 parts of Fructus Hordei Germinatus (parched)s, 15 parts of Cortex Albiziaes and Semen Lablab Albums.

Described medicament is capsule.

The preparation method of medicine of the present invention is:

Get by weight 30 parts of crude drug Radix Astragali, 30 parts of Rhizoma Dioscoreaes, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 30 parts of Semen Coiciss, 10 parts of Rhizoma Coptidis, 30 parts of Herba Taraxacis, 15 parts of Radix Angelicae Sinensis, 6 parts of Radix Glycyrrhizae Preparatas, 20 parts of Herba Dendrobiis, 15 parts of the Cortexs Eucommiae, 10 parts of Radix Scutellariaes, 15 parts of Radix Dipsacis, 15 parts, Poria, 10 parts of Semen Oroxylis, 6 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 30 parts of Herba Agrimoniaes, 10 parts of Fructus Amomis, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of the Radix Paeoniae Albas, 10 parts of Fructus Aurantiis, 10 parts of Fructus Hordei Germinatus (parched)s, 15 parts of Cortex Albiziaes and 15 parts of Semen Lablab Albums standby;

Second step: after the above-mentioned raw materials medicine is mixed, be dried and crushed into fine flour, cross 500 mesh sieves, incapsulate and get final product.

Digestion-promoting spleen-invigorating Chinese medicine composition provided by the invention, its raw material is Radix Astragali, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae (parched), Semen Coicis, Rhizoma Coptidis, Herba Taraxaci, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Herba Dendrobii, the Cortex Eucommiae, Radix Scutellariae, Radix Dipsaci, Poria, Semen Oroxyli, Fructus Hordei Germinatus (parched), Ramulus Cinnamomi, Herba Agrimoniae, Fructus Amomi, the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, Fructus Aurantii, Radix Glycyrrhizae, Cortex Albiziae and Semen Lablab Album, can be used for the vomiting that treatment causes because of insufficiency of the spleen and dyspepsia, abdominal distention and become thin etc., the effect with certain digestion-promoting spleen-invigorating that above-mentioned medical material has, the effect with certain building body had, this formula is in R&D process, the formula of take in the patent of applying on the same day is core, the additional formula drawn by increase and decrease flavour of a drug and adjustment compatibility relationship, wherein add Fructus Hordei Germinatus (parched) as adjuvant drug, add Radix Glycyrrhizae as making medicine, coordinating the actions of various ingredients in a prescription, nourishing the stomach gas, Radix Glycyrrhizae matches in conjunction with Fructus Hordei Germinatus, can also protect gastric qi, prevent that thing from injuring one's stomach.So and after the above-mentioned raw materials medicine carries out the compatibility of rational proportion according to the combination principle of monarch; strengthened the effect of protection gastric qi; obtained at insufficiency of the spleen, dyspepsia, vomiting, abdominal distention for the treatment of and the aspect such as become thin the curative effect of showing, made this medicine aspect digestion-promoting spleen-invigorating and have no side effect to have produced beyond thought effect.Through 1 year, observe both without recurring also without obvious toxic and side effects.

The specific embodiment

A kind of medicine of digestion-promoting spleen-invigorating, by following bulk drugs, made:

Radix Astragali 30g, Rhizoma Dioscoreae 30g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Semen Coicis 30g, Rhizoma Coptidis 10g, Herba Taraxaci 30g, Radix Angelicae Sinensis 15g, Radix Glycyrrhizae Preparata 6g, Herba Dendrobii 20g, Cortex Eucommiae 15g, Radix Scutellariae 10g, Radix Dipsaci 15g, Poria 15g, Semen Oroxyli 10g, Radix Glycyrrhizae 6g, Ramulus Cinnamomi 10g, Herba Agrimoniae 30g, Fructus Amomi 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Paeoniae Alba 15g, Fructus Aurantii 10g, Fructus Hordei Germinatus (parched) 10g, Cortex Albiziae 15g and Semen Lablab Album 10g;

Second step: after the above-mentioned raw materials medicine is mixed, be dried and crushed into fine flour, cross 500 mesh sieves, incapsulate and get final product.Every capsule has above-mentioned raw materials medicine 0.4g.

The drug effect of each crude drug of distinguishing the flavor of is as follows:

1. Radix Astragali: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.

2. Rhizoma Dioscoreae: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.

3. Rhizoma Atractylodis Macrocephalae (parched): invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.

4. Semen Coicis: spleen invigorating, eliminating dampness by diuresis, antidiarrheal, evacuation of pus.

5. Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.

6. Herba Taraxaci: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.

7. Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

8. Radix Glycyrrhizae Preparata: spleen reinforcing stomach function regulating, Yiqi and vein recovery.

9. Herba Dendrobii: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.

10. the Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.

11. Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.

12. Radix Dipsaci: invigorating the liver and kidney, bone and muscle strengthening, continuous folding wound, only metrorrhagia.

13. Poria: the Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.

14. Semen Oroxyli: lung moistening, soothing liver-QI, stomach function regulating, granulation promoting.

15. Radix Glycyrrhizae: QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.

16. Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation.

17. Herba Agrimoniae: astringing to arrest bleeding, detoxification sore treatment, parasite killing, puckery antiperspirant, cough-relieving.

18. Fructus Amomi: the removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.

19. the Pseudobulbus Bletillae (Rhizoma Bletillae): tonifying the lung, relieving cough and resolving phlegm, hemostasia and promoting granulation.

20. the Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.

21. Fructus Aurantii: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.

22. Semen Lablab Album: spleen reinforcing and in, removing dampness is relieved summer heat.

23. Fructus Hordei Germinatus (parched): promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back newborn relieving distension.

24. Cortex Albiziae: the resolving depression of calming the nerves is arranged, the effect of the eliminating carbuncle of invigorating blood circulation.

Instructions of taking: the people more than 18 years old three times on the one, each 1.Within 30 days, be a course for the treatment of, take continuously three courses for the treatment of.As taken continuously 1 week symptom without obviously changing or take medicine rear appearance diarrhoea and vomiting increase the weight of, drug withdrawal immediately, transference cure after drug withdrawal.

Clinical trial:

Choose 150 routine functional dyspepsias and with gastrointestinal upset as vomiting, abdominal distention and the Patients of Spleen Deficiency of becoming thin, in age 18-50 year, the course of disease is more than 3 months, in 2 months, do not carry out any treatment.Above-mentioned 150 routine patients are divided into to two groups for the treatment of group and matched groups, treatment group 100 examples, the capsule made with this enforcement is treated, and three times on the oral one, each 1 30 days is a course for the treatment of, takes continuously three courses for the treatment of.Matched group 50 examples, take the domperidone tablet treatment: oral, 10～20mg or suspension 10ml, every day 3～4 times, take 15～30 minutes ante cibum, within 15 days, is a course for the treatment of, takes continuously three courses for the treatment of.Then carry out clinical observation.

Period in a medicine treatment group self clinical observation on the therapeutic effect analysis result is as follows:

The curative effect project	The treatment group number of cases	Improvement rate (%)
			The vomiting number of times reduces	95	95%
Abdominal distention is alleviated	84	84%
			Body weight increases	85	85%
Appetite increases	93	93%
			Total improvement rate (%)	?	89.25%

The clinical observation on the therapeutic effect analysis result of period in a medicine treatment group and matched group is as follows:

Efficacy assessment standard is as follows:

1, produce effects: vomiting is obviously controlled, and abdominal distention is obviously alleviated, and body weight increases, and appetite increases, the transference cure of all the other gastrointestinal upsets.

2, take a turn for the better: the vomiting number of times reduces or the intermittent time extends, and abdominal distention is alleviated to some extent, and body weight stops alleviating, and appetite makes moderate progress, and the symptom partial symptoms of all the other gastrointestinal upsets disappears.

3, invalid: symptom is without improving or increasing the weight of.

The comparison sheet of the clinical medicine side effect incidence rate of period in a medicine treatment group and matched group

Stomachache and Refuse to take medicine are clinical modal side effect as can be seen from the above table, but can progressively disappear after drug withdrawal.But tremble and the incidence rate of the side effect of having blood in stool, take the matched group of domperidone tablet apparently higher than the treatment group of taking capsule of the present invention, so the present invention does not have obvious toxic and side effects substantially.

Claims (2)

1. the medicine of a digestion-promoting spleen-invigorating is characterized in that it is the medicament of being made by the crude drug of following parts by weight:

15 parts of 30 parts of Radix Astragali, 30 parts of Rhizoma Dioscoreaes, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 30 parts of Semen Coiciss, 10 parts of Rhizoma Coptidis, 30 parts of Herba Taraxacis, 15 parts of Radix Angelicae Sinensis, 6 parts of Radix Glycyrrhizae Preparatas, 20 parts of Herba Dendrobiis, 15 parts of the Cortexs Eucommiae, 10 parts of Radix Scutellariaes, 15 parts of Radix Dipsacis, 15 parts, Poria, 10 parts of Semen Oroxylis, 6 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 30 parts of Herba Agrimoniaes, 10 parts of Fructus Amomis, 15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of the Radix Paeoniae Albas, 10 parts of Fructus Aurantiis, 10 parts of Fructus Hordei Germinatus (parched)s, 15 parts of Cortex Albiziaes and Semen Lablab Albums.

2. the medicine of digestion-promoting spleen-invigorating according to claim 1, is characterized in that described medicament is capsule.