CN104435685A - Medicine for treating xerophthalmia and preparation method thereof - Google Patents

Medicine for treating xerophthalmia and preparation method thereof Download PDF

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CN104435685A
CN104435685A CN201410703950.0A CN201410703950A CN104435685A CN 104435685 A CN104435685 A CN 104435685A CN 201410703950 A CN201410703950 A CN 201410703950A CN 104435685 A CN104435685 A CN 104435685A
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medicine
parched
tablet
radix
xerophthalmia
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顾蔷怡
高春娟
冷盛君
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/815—Lycium (desert-thorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a medicine for treating xerophthalmia and a preparation method thereof. The medicine is formed by combining bidens pilosa, chrysanthemum, periostracum cicadae, red peony roots, liquorice, mint, fructus lycii, stir-fried white peony roots, poria cocos, ophiopogon japonicas, largehead atractylodes rhizome stir-fried in wheat bran and honey-made mulberry root barks in a certain proportion. The traditional Chinese medicine composition can clear away heat and toxic materials, activate blood, eliminate stagnant blood, promote lacrimation, nourish liver and kidney, replenish vital essence to improve vision, cool blood, eliminate swelling, calm down, relieve pains and resist to inflammation and bacteria, thereby having a good curative effect on xerophthalmia without any toxic or side effects.

Description

A kind of medicine for the treatment of xerophthalmia and preparation method thereof
Technical field
The present invention relates to a kind of is Chinese medicine composition of crude drug and preparation method thereof by Chinese herbal medicine, relates to a kind of medicine for the treatment of xerophthalmia and preparation method thereof specifically.
Background technology
Xerophthalmia, also known as angle conjunctival xerosis, is the lazy weight or of poor quality due to tear, causes the syndrome of eye dryness.It is dry and astringent that the general symptom of xerophthalmia is that eyes have, causalgia sense, and gum is more; Eye acid, ophthalmic pruritus, keep in dark place and visual deterioration.Other symptoms also have headache, agitation, fatigue, attention to be difficult to concentrate, and keratomalacia perforation occurring time serious, can see there is conjunctival congestion when checking.
Xerophthalmia can be described as one " computer vision syndrome ".Eyes, particularly cornea part, be often rely on lachrymal gland supply moisture, by nictation, make tear become one deck " tear sheet " and be distributed to cornea, keep eyes comfortable.So-called " xerophthalmia " refers to because the minimizing of tear or lacrimal gland function decline, and causes eye exhibits to go out a kind of symptom of small scar.
At present, xerophthalmia doctor trained in Western medicine theory it be unclear that, and generally acknowledges effective medicine so also lack.
Summary of the invention
The present invention, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, proposes a kind of medicine for the treatment of xerophthalmia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Herba Bidentis Bipinnatae 25-35g, Flos Chrysanthemi 3-9g, Periostracum Cicadae 3-9g, Radix Paeoniae Rubra 4-14g, Radix Glycyrrhizae 3-5g, Herba Menthae 3-9g, Fructus Lycii 4-14g, Radix Paeoniae Alba (parched) 4-14g, Poria 4-14g, Radix Ophiopogonis 4-14g, Rhizoma Atractylodis Macrocephalae (parched with bran) 4-14g, honey-made mulberry bark 4-14g.Optimum ratio is: Herba Bidentis Bipinnatae 30g, Flos Chrysanthemi 6g, Periostracum Cicadae 6g, Radix Paeoniae Rubra 10g, Radix Glycyrrhizae 3g, Herba Menthae 6g, Fructus Lycii 10g, Radix Paeoniae Alba (parched) 10g, Poria 10g, Radix Ophiopogonis 10g, Rhizoma Atractylodis Macrocephalae (parched with bran) 10g, honey-made mulberry bark 10g.Described medicament is decoction, capsule, tablet or pill.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Herba Bidentis Bipinnatae, Flos Chrysanthemi, Periostracum Cicadae, Radix Paeoniae Rubra, Radix Glycyrrhizae, Herba Menthae, Fructus Lycii, Radix Paeoniae Alba (parched), Poria, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae (parched with bran), honey-made mulberry bark pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
the pharmacology of medicine material medicine of the present invention is as follows:
Herba Bidentis Bipinnatae: Herba Bidentis Bipinnatae is distributed in the subtropical and tropical zones in Asia and America, and the East China of China, Central China, south China, southwestern each provinces and regions, be grown on the wasteland, roadside of height above sea level 50-3100 rice, hillside and field.For folks of china commonly uses medical herbs, there is effect of heat-clearing and toxic substances removing, removing blood stasis and activating blood flow, cure mainly upper respiratory tract infection, laryngopharynx swelling and pain, acute appendicitis, acute icterohepatitis, gastroenteritis, Fengshi Guanjie pain, malaria, furuncle, venom, treating swelling and pain by traumatic injury are controlled in external.Herba Bidentis Bipinnatae is containing a large amount of choline, and non-anti-inflammation components, but can cause side effect as salivation, shed tears.
Flos Chrysanthemi: the merit having dispelling wind, suppressing the hyperactive liver, can expelling wind and removing dampness, reducing swelling and alleviating pain, for having a dizzy spell, the treatment of the disease of wind-heat troubling.
Periostracum Cicadae: have dispelling wind-heat, rash sore-throat relieving, removing nebula to improve visual acuity, the effect of expellingging wind and relieving convulsion, control affection due to external wind and heat, cough hoarseness, measles is sent out smooth thoroughly, rubella pruritus, pediatric epilepsy scared, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.
Radix Paeoniae Rubra: there is clots absorbing, pain relieving, removing heat from blood, detumescence effect, cure mainly: control the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, suffer from abdominal pain, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.
Radix Glycyrrhizae:. for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness, ulcer sores, laryngopharynx swelling and pain, asthma and cough etc.
Herba Menthae: have the improving eyesight that clears away heart-fire, sweating and heat resolving effect, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.
Fructus Lycii: have nourishing the liver and kidney, replenishing vital essence to improve eyesight effect, cures mainly nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix Paeoniae Alba (parched): cool in nature, bitter in the mouth acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.
Poria: there is promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves.Swelling of harnessing the river is full, dysuria, the anorexia and loose stool of insufficiency of the spleen leading to overabundance of dampness, severe palpitation, insomnia forgetfulness etc.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Radix Ophiopogonis: sweet, micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire effect.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Rhizoma Atractylodis Macrocephalae (parched with bran): have and relax dry property, in entering, strengthens spleen invigorating, detumescence effect by means of bran, for incoordination between the spleen and stomach, and dysfunction of the spleen in transportation and transformation, lack of appetite distension fatigue and weakness, exterior deficiency spontaneous perspiration.
Honey-made mulberry bark: there is blood pressure lowering, diuresis, sedation and analgesia, antiinflammatory, antibacterial, anticoagulant, effect of antipyretic, expelling phlegm for arresting cough.
The present invention take Herba Bidentis Bipinnatae as monarch drug, and heat-clearing and toxic substances removing, removing blood stasis and activating blood flow, promotion are shed tears.With Fructus Lycii, Radix Paeoniae Alba (parched), Poria, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae (parched with bran), Radix Paeoniae Rubra, honey-made mulberry bark for ministerial drug, nourishing the liver and kidney, replenishing vital essence to improve eyesight, blood-supplementing blood-nourishing, suppressing liver-YANG, astringing YIN to stop sweating, promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing, YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and strengthens spleen invigorating, clots absorbing pain relieving, removing heat from blood is subsided a swelling, antihypertensive diuretic, sedation and analgesia, anti-inflammatory, antibacterial.Assistant is with Flos Chrysanthemi, Periostracum Cicadae, Herba Menthae, and make with Radix Glycyrrhizae, dispelling wind suppressing the hyperactive liver, expelling wind and removing dampness, reducing swelling and alleviating pain, dispelling wind-heat, removing nebula to improve visual acuity, expellings wind and relieving convulsion, and clear away heart-fire improving eyesight, sweating and heat resolving.Medicine of the present invention holds the marrow of the traditional Chinese medical science, rigorous prescription, and all medicine monarch share, and mends broken combination, brings out the best in each other, meet the principle of traditional Chinese medical science medicine law and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.
beneficial effect
Chinese medicine composition of the present invention can be shed tears in heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, promotion, and nourishing the liver and kidney, replenishing vital essence to improve eyesight, removing heat from blood is subsided a swelling, sedation and analgesia, anti-inflammatory, antibacterial, has good curative effect, and have no side effect to treatment xerophthalmia.
Beneficial effect for a better understanding of the present invention, clinical trial is as follows:
select case
Select clinical patients with dry eye 120 example, man 71 example, female 49 example, 29 years old mean age;
Be divided into two groups at random: treatment group 70 example, matched group 50 example.
diagnostic method
Normal time uses the patient of computer, and often plays the patient of mobile phone, and go out to lose face dry, eye is puckery, eyestrain, with causalgia sense, many with gum, eye acid, ophthalmic pruritus, keeps in dark place and visual deterioration.
therapeutic Method
Treatment group takes the made capsule of embodiment 2, and the morning, noon and afternoon, respectively once each 4, every 0.3g 1 month was a course for the treatment of;
Matched group takes Cebo-Caps;
the standard of curative effect evaluation
Cure: eye is done, and eye is puckery, eyestrain's transference cure, causalgia sense, and eye acid, ophthalmic pruritus, keep in dark place disappearance; Do not recur in half a year;
Effective: eye is done, and eye is puckery, eyestrain's remission is lost, causalgia sense, and eye acid, ophthalmic pruritus, keeping in dark place alleviates;
Invalid: symptom increases the weight of without significant change or disease;
Total effective rate=cure rate+effective percentage.
statistical data
Group Case load Cure Effectively Invalid Cure rate Total effective rate
Treatment group 70 27 39 4 38.57% 94.29%
Matched group 50 0 3 47 0 6.00%
conclusion
According to test diagnosis method and the standard of curative effect evaluation, treat according to therapeutic scheme 70 routine patients with dry eyes, cure 27 examples, cure rate is 38.57%, effective 39 examples, and invalid 4 examples, total effective rate reaches 94.29%.Matched group is without significant change.As can be seen here, medicine of the present invention can effectively be alleviated and treat xerophthalmia.
acute toxicity test:larger dose and take to the growth of rat without remarkable toxicity compared with long-term therapy, have no overt toxicity damage to the chip form inspection such as brain, the heart, liver, kidney of rat and change, test display, this drug toxicity is very little.
Detailed description of the invention
embodiment 1:a kind of medicine for the treatment of xerophthalmia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Herba Bidentis Bipinnatae 25-35g, Flos Chrysanthemi 3-9g, Periostracum Cicadae 3-9g, Radix Paeoniae Rubra 4-14g, Radix Glycyrrhizae 3-5g, Herba Menthae 3-9g, Fructus Lycii 4-14g, Radix Paeoniae Alba (parched) 4-14g, Poria 4-14g, Radix Ophiopogonis 4-14g, Rhizoma Atractylodis Macrocephalae (parched with bran) 4-14g, honey-made mulberry bark 4-14g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Herba Bidentis Bipinnatae 25-35g, Flos Chrysanthemi 3-9g, Periostracum Cicadae 3-9g, Radix Paeoniae Rubra 4-14g, Radix Glycyrrhizae 3-5g, Herba Menthae 3-9g, Fructus Lycii 4-14g, Radix Paeoniae Alba (parched) 4-14g, Poria 4-14g, Radix Ophiopogonis 4-14g, Rhizoma Atractylodis Macrocephalae (parched with bran) 4-14g, honey-made mulberry bark 4-14g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Herba Bidentis Bipinnatae, Flos Chrysanthemi, Periostracum Cicadae, Radix Paeoniae Rubra, Radix Glycyrrhizae, Herba Menthae, Fructus Lycii, Radix Paeoniae Alba (parched), Poria, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae (parched with bran), honey-made mulberry bark pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
embodiment 2:a kind of medicine for the treatment of xerophthalmia and preparation method thereof.It is the medicament be prepared from by the crude drug of following parts by weight proportioning: Herba Bidentis Bipinnatae 30g, Flos Chrysanthemi 6g, Periostracum Cicadae 6g, Radix Paeoniae Rubra 10g, Radix Glycyrrhizae 3g, Herba Menthae 6g, Fructus Lycii 10g, Radix Paeoniae Alba (parched) 10g, Poria 10g, Radix Ophiopogonis 10g, Rhizoma Atractylodis Macrocephalae (parched with bran) 10g, honey-made mulberry bark 10g.Described medicament is capsule, tablet or pill.
According to following portions by weight proportioning weighting raw materials:
Herba Bidentis Bipinnatae 30g, Flos Chrysanthemi 6g, Periostracum Cicadae 6g, Radix Paeoniae Rubra 10g, Radix Glycyrrhizae 3g, Herba Menthae 6g, Fructus Lycii 10g, Radix Paeoniae Alba (parched) 10g, Poria 10g, Radix Ophiopogonis 10g, Rhizoma Atractylodis Macrocephalae (parched with bran) 10g, honey-made mulberry bark 10g.
The preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Herba Bidentis Bipinnatae, Flos Chrysanthemi, Periostracum Cicadae, Radix Paeoniae Rubra, Radix Glycyrrhizae, Herba Menthae, Fructus Lycii, Radix Paeoniae Alba (parched), Poria, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae (parched with bran), honey-made mulberry bark pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
Mixture described in step (2), the preferred number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
Embodiment 3: medicine of the present invention can also be decoction, oral liquid, granule etc.

Claims (5)

1. treat a medicine for xerophthalmia, it is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Herba Bidentis Bipinnatae 25-35g, Flos Chrysanthemi 3-9g, Periostracum Cicadae 3-9g, Radix Paeoniae Rubra 4-14g, Radix Glycyrrhizae 3-5g, Herba Menthae 3-9g, Fructus Lycii 4-14g, Radix Paeoniae Alba (parched) 4-14g, Poria 4-14g, Radix Ophiopogonis 4-14g, Rhizoma Atractylodis Macrocephalae (parched with bran) 4-14g, honey-made mulberry bark 4-14g.
2. the medicine for the treatment of xerophthalmia according to claim 1, is characterized in that it is the medicament be prepared from by the crude drug of following parts by weight proportioning: Herba Bidentis Bipinnatae 30g, Flos Chrysanthemi 6g, Periostracum Cicadae 6g, Radix Paeoniae Rubra 10g, Radix Glycyrrhizae 3g, Herba Menthae 6g, Fructus Lycii 10g, Radix Paeoniae Alba (parched) 10g, Poria 10g, Radix Ophiopogonis 10g, Rhizoma Atractylodis Macrocephalae (parched with bran) 10g, honey-made mulberry bark 10g.
3. the medicine for the treatment of xerophthalmia according to claim 1 and 2, is characterized in that: described medicament is decoction, capsule, tablet or pill.
4. the medicine for the treatment of xerophthalmia according to claim 3, is characterized in that: the preparation method step of described capsule, tablet, pill is as follows:
(1) in the side of getting, Herba Bidentis Bipinnatae, Flos Chrysanthemi, Periostracum Cicadae, Radix Paeoniae Rubra, Radix Glycyrrhizae, Herba Menthae, Fructus Lycii, Radix Paeoniae Alba (parched), Poria, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae (parched with bran), honey-made mulberry bark pulverize screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), collecting decoction, filtration, worry liquid is condensed into 70-80 when spending, capsule, pill relative density are the thick paste of 1.0-1.6, and tablet relative density is the thick paste of 1.0-1.4;
(3) when making capsule, pill:
By thick paste separation and purification, drying, make dry granule; By dry granule mix homogeneously, in filled capsules, namely make capsule; Dry granule spray is added refined honey, mix homogeneously, makes piller and namely make pill;
When making tablet:
2-4 part starch is mixed homogeneously with the thick paste in step (2), makes granule, drying, make dry granule, dry granule is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of xerophthalmia according to claim 4, is characterized in that the mixture described in step (2), and the number of times decocted with water is 2 times, and first time is 60-80 minute, and second time is 40-60 minute.
CN201410703950.0A 2014-11-30 2014-11-30 Medicine for treating xerophthalmia and preparation method thereof Pending CN104435685A (en)

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WO2019124854A1 (en) * 2017-12-22 2019-06-27 한국한의학연구원 Composition for preventing or treating dry eye syndrome, containing mixed extract or fraction thereof

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CN103142968A (en) * 2013-03-22 2013-06-12 宋贤 Medicine for treating dry eye syndromes
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906430A (en) * 2015-06-30 2015-09-16 陈红 Traditional Chinese medicine preparation for treating xerophthalmia and preparation method thereof
WO2019124854A1 (en) * 2017-12-22 2019-06-27 한국한의학연구원 Composition for preventing or treating dry eye syndrome, containing mixed extract or fraction thereof

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Application publication date: 20150325