CN104740405B - A kind of Chinese medicine preparation and preparation method for treating anaphylactoid purpura renal damage - Google Patents

Abstract

The invention discloses a kind of Chinese medicine preparations for treating anaphylactoid purpura renal damage, it is made of Radix Astragali, honeysuckle, dandelion, windproof, radix rehmanniae recen, the root bark of shaggy-fruited dittany, the fruit of summer cypress, Radix Angelicae Sinensis, radix scutellariae, radix paeoniae rubra, Radix Paeoniae Alba, moutan bark, eclipta, Asian puccoon, cicada slough, sophora flower, cornu bubali, rhizoma nelumbinis, rhizoma imperatae, hairyvein agrimony, the root bark of white mulberry, radix scrophulariae, licorice according to certain weight proportion, have effects that clearing heat and detoxicating, tonifying Qi and lifting yang, nourishing Yin and promoting production of body fluid, removing blood stasis and analgesics, can effectively treat anaphylactoid purpura renal damage.

Description

A kind of Chinese medicine preparation and preparation method for treating anaphylactoid purpura renal damage

Technical field

The present invention relates to a kind of Chinese medicine preparations, and in particular to a kind of Chinese medicine preparation for treating anaphylactoid purpura renal damage. The invention further relates to the preparation methods of the Chinese medicine preparation.

Background technology

Anaphylactoid purpura renal damage（Henoch-Schonlein purpura, HSP, anaphy lactoid purpura）It is one group using the popularity Capillaritis caused by allergy as the clinical syndrome of main pathological basis, including , also there is upper gastrointestinal bleeding sometimes in characteristic fash, cramp, arthralgia and glomerulonephritis.Simultaneously due to cutaneous lesions It is not the only feature of the disease, many scholars think that " anaphylactoid purpura " cannot be known as merely, and use " Hchonlein-Henoch Syndrome " is referred to as more appropriate.Since anaphylactoid purpura patient about 1/3 appears above renal damage, prognosis depends primarily on kidney The severity of lesion, therefore the renal damage caused by anaphylactoid purpura is known as anaphy lactoid purpura nephritis.

At the beginning of Chinese medicine thinks the morbidity of anaphylactoid purpura glomerulonephritis, it is mostly patient's element to have diseases caused by external factors medical history, the interpretation of the cause, onset and process of an illness more Have in blood-head and accumulates, multiple because the shake-up such as diseases caused by external factors, diet, worm poison, drug or chemical toxicant, wind-heat are mutually fought, blood network of burning, so that compeling blood Absurd row, excessive skin, interior urgent stomach notably and kidney, therefore have skin purpura, and abdominal pain frequency is made, and very then have blood in stool, hematuria etc.；It is long then hinder And kidney yin, cause is fire excess from yin deficiency, and blood network of intimately burning injures kidney and bladder blood network, and sees purple plague purpura, hematuria.It is understood that mistake Sensitive purpura nephritis it is fire excess from yin deficiency be both warm disease and evil with the passing of time the pathological product of heat consumption body fluid and cause purple plague purpura, The etiology and pathogenesis of hematuria；Misdiagnosis is controlled in prolonged illness mistake, then can injure spleen kidney, causes speen-kidney dificiency, deficiency of spleen-QI, then transformation failure of spleen, water are wet It does not transport, deficiency of kidney-QI, then cannot change gas row water, lead to bladder qi dysfunction, open and close unfavorable, spleen kidney qi deficiency, water is wet to spread unchecked then body Swollen, kidney loses folding then renal shutdown, the clinical manifestations such as oliguria, oedema to form anaphylaxis purplish or white patches on the skin ephritis.In conclusion anaphylaxis Purpura nephritis is mainly related with lung, spleen, three dirty malfunction of kidney, especially dirty in close relations with spleen kidney two.It is i.e. so-called that " it is marked on Lung, the fundamental cause of water disease being in the kidney are made in spleen ".It is invaded in wind-heat, blood system latent heat, stagnation of blood stasis and the unbalance of spleen kidney negative and positive of qi and blood are this diseases The interpretation of the cause, onset and process of an illness.

It is main to consider have with infection and allergy since the cause of disease of anaphylactoid purpura renal damage is still uncertain at present It closes, therefore there are no the drugs of exact this disease for the treatment of for Western medicine at present, although cortex hormone of aadrenaline etc. is with obvious effects to purpura, But it is undesirable to purpura nephritis curative effect, therefore there is an urgent need to a kind of medicines for treating anaphylactoid purpura injury of kidney now Object.

Invention content

The object of the present invention is to provide a kind of Chinese medicine preparations, and the Chinese medicine preparation is for treatment anaphylactoid purpura renal damage tool It is effective in cure significantly, it is cheap, have no toxic side effect, the characteristics for the treatment of both manifestation and root cause of disease.

It is a further object of the present invention to provide the preparation methods of the Chinese medicine preparation of the treatment anaphylactoid purpura renal damage.

Inventor observes the pain that anaphylactoid purpura renal damage is brought to patient in clinical treatment practice for many years Hardship, according to the rule of development of the illness and the combination principle of Chinese medicine, and by a large amount of clinical verification, Exploration and conclusion repeatedly Go out a kind of new formula of Chinese medicine preparation that treating anaphylactoid purpura renal damage, the present invention select Radix Astragali, honeysuckle, dandelion, Windproof, radix rehmanniae recen, the root bark of shaggy-fruited dittany, the fruit of summer cypress, Radix Angelicae Sinensis, radix scutellariae, radix paeoniae rubra, Radix Paeoniae Alba, moutan bark, eclipta, Asian puccoon, cicada slough, sophora flower, water Ox horn, rhizoma nelumbinis, rhizoma imperatae, hairyvein agrimony, the root bark of white mulberry, radix scrophulariae, licorice are combined, these pharmaceutical compositions are made each drug work( Effect generates synergistic effect, the effect of with clearing heat and detoxicating, tonifying Qi and lifting yang, nourishing Yin and promoting production of body fluid, removing blood stasis and analgesics, so as to effective Treat anaphylactoid purpura renal damage.

The effect of drug in the present invention：

Wherein：

Radix Astragali：For legume astragalus mongolicus Astragalus membranaceus（Fisch.） Bge. var. mongholicus （Bge.）Hsiao or Astragalus membranacus Astragalus membranaceus（Fisch.）Bge. dry Dry.Nature and flavor：It is sweet, tepor.Return lung, spleen, liver and kidney channel.Effect：Tonifying Qi and lifting yang, inducing diuresis for removing edema, torr sore apocenosis, leads to solid table arrest sweating Water transfer road.《Collected statements on the herbal foundation》In it is on the books：" Radix Astragali, tonifying lung invigorating the spleen, defend arrest sweating in fact, and wind dispelling transports the medicine of poison.Therefore the deficiency of yang it People, spontaneous perspiration frequency, is exterior deficiency and interspaces of skin and muscles being loose, Radix Astragali can be defended and arrest sweating in fact；The card of typhoid fever, row is delivered and evil sweat does not go out, It is interior deficiency and weary in healthy tendency, Radix Astragali can help Tianjin to help sweat；The disease of harmful wind, not with person, Radix Astragali can be with by inclined invasion of vessels and brothers Flourish muscles and bones；The card of large carbuncle is burst in purulence blood, and yang-energy void is without the person of holding back, and Radix Astragali can be with myogenic meat, and the erosion of vulva cannot rise, and yang-energy is empty And unhealed, Radix Astragali can be with myogenic meat." this product is in vitro to Shigella shigae, bacillus anthracis, A type hemolytic hammer Bacterium, beta hemolytic streptococcus, corynebacterium diphtheriae, bacillus pseudodiphthericus, Diplococcus pneumopniae, staphylococcus aureus, lemon yellow grape Coccus, hay bacillus etc. have inhibiting effect.Radix Astragali is good at tonifying middle-Jiao and Qi, is the key medicine of tonifying Qi and lifting yang, and tonifying Qi diuresis, with Detumescence.In addition there is certain curative effect with Astragalus in Treating chronic nephritis.

Honeysuckle：For caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicera Hypoglauca Miq., Honeysuckle flower（Hair calyx honeysuckle）Lonicera confusa DC. or hair style honeysuckle Lonicera The dry flower of dasystyla Rehd. or with the flower just opened.Nature and flavor：It is sweet, cold.Return lung, the heart, stomach.Effect：It is clearing heat and detoxicating, Wind-dispelling heat-dissipating.This product is sweet in flavor and cold in property, can it is clearing heat and detoxicating and dissipate carbuncle detumescence, to treat the key medicine of all yang syndrome carbuncle swells furunculosis. Clinically it is used for ulcer serious case of furuncle：Often it is equal with Herba Violae, wild chrysanthemum and uses, antipyretic and antidote functions can be enhanced, can be used to ulcer serious case of furuncle, Congestion and swelling pain.Ancient prescription is recorded, and honeysuckle controls all pyogenic infections, pays no attention to have burst and not burst, or from the beginning of fever, and furunculosis bubo, larynx numbness are newborn Moth：Honeysuckle（Even cauline leaf）Half bowl of natural juice, decoct eight sub-services it, applied with dregs, Toxin-Vanquishing Tuoli, air-dispersing and blood, work(solely win.

Dandelion：Dandelion also known as bed-wetting grass, is feverfew dandelion Toraxacum mongolicum Hand. Mazz., dandelion Toraxacum borealisinense Kitam. or the drying herbs of several plants is belonged to alkali.Property Taste：Sweet, slight bitter is trembled with fear.Return liver, stomach.Effect：It is clearing heat and detoxicating, dispersing swelling and dissipating binds.Dandelion has anti-inflammatory, antibacterial, antitumor, clear The effect of thermal detoxification, has a wide range of application on modern clinic, makes good use of.For furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharyngalgia, lung Carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.

It is windproof：For umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata（Turcz.）Schischk. dry Dry.Nature and flavor：Pungent, sweet, tepor.Return bladder, lung, spleen, Liver Channel.Effect：It expels pathogenic wind from the body surface, is expel endogenous wind to relieve convulsion, spasmolysis, antipruritic.For Diseases caused by external factors exterior syndrome or rubella itch.This product slightly warm in nature is sweet slow without high without dry, there is the title of " the profit agent in expelling wind drug ", no matter chill, Syndrome of superficies attacked by wind-heat can be applied.This product can be additionally used in lockjaw, teeth clenched, opisthotonos.It is windproof to control lockjaw, there is expelling wind and relieving convulsion Effect.

Radix rehmanniae recen：For the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch.. Nature and flavor：It is sweet, cold.The thoughts of returning home, liver and kidney channel.Effect：Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid.It can be used for injury thirst, Heat Diabetes.This product is sweet It is cold, can among heat-clearing nourishing Yin and promoting production of body fluid, it is cold in nature and enter blood system, can not only clear ying blood point heat and cool blood, and energy cold in nature sweet in flavor It promotes the production of body fluid, there is nourishing Yin and clearing heat, be often equal with Radix Ophiopogonis, the root of straight ladybell and use.For treating blood-head tells nosebleed, uterine bleeding of having blood in stool, warm disease heat enters Ying blood is often used together with moutan bark, radix paeoniae rubra.

The root bark of shaggy-fruited dittany：It is the root skin of Rutaceae herbaceos perennial shaggy-fruited dittany Dictamnus dasycarpus Turcz..Property Taste：It is bitter, salty, cold.Returns spleen, lung, small intestine, stomach, bladder warp.Function：Heat-clearing and damp-drying drug；Dispelling wind and arresting itching；Removing toxic substances.《Haigoushen》：" control one Heat toxin wind is cut, foul wind, wind sore, mange are red rotten, and eyebrow hair is de- crisp, and musculus cutaneus is anxious, high fever aversion to cold；Principal solution heat Huang, wine Huang, acute febrile, paddy Huang, Labor Huang etc.." modern pharmacology research, the root bark of shaggy-fruited dittany is with antibacterial action：In vitro test 1：4 infusion to a variety of pathomycetes such as Trichophyton, Trichophyton concentricum, oidium schoenleinii have different degrees of inhibiting effect, but have the second of report this product Ether, ethyl alcohol and water extract are showed no effect to the coccuses such as golden yellow, Escherichia coli Pseudomonas aeruginosa and Mycobacterium graminis.

The fruit of summer cypress：For chenopod summer cypress Kochia scoparia（L.）Schrad. dry mature fruit.Nature and flavor： It is pungent, bitter, it trembles with fear.Return kidney, bladder warp.Effect：Clearing heat and promoting diuresis, dispelling wind and arresting itching.For difficulty and pain in micturition, under pruritus vulvae band, rubella, eczema, Pruitus.

Radix Angelicae Sinensis：For the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor： It is sweet, pungent, bitter, temperature.Return liver, the heart, the spleen channel.Effect：It enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.Radix Angelicae Sinensis Central nervous system There are inhibiting effect, volatile oil to have the effects that calmness, hypnosis, analgesia, anesthesia.For blood deficiency chlorosis, dizziness palpitaition, asthenia cold abdominalgia, Arthralgia pain due to rheumatism, injury from falling down, ulcer sores.According to《Book on Chinese herbal medicine is just》It carries：" its is sweet in flavor and weighs, therefore can specially enrich blood, and gas is light and pungent, therefore Again can promoting circulation of blood, nutrition blood can be supported, tonifying Qi production of sperm, five viscera settling, strengthen body, beneficial mind, all tangible deficient diseases are omni-benefiting." existing It is confirmed for medical research, Radix Angelicae Sinensis has antibacterial, antiinflammation, when Radix Angelicae Sinensis hot water extract is to chronic articular rheumatism acute attack There is apparent inhibiting effect.

Radix scutellariae：For the dry root of labiate radix scutellariae Scutellaria baicalensis Georgi.Nature and flavor： Hardship is trembled with fear.Return lung, courage, spleen, stomach, large intestine, small intestinl channel.Effect：Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, tocolysis, blood pressure lowering.Radix scutellariae Clinical application antibacterial it is relatively good, and do not develop immunity to drugs.This product has the work(of clearing heat and cooling blood hemostasis, burning hot flourishing with controlling, and compels The haematemesis of the absurd row of blood, uterine bleeding are had blood in stool.

Radix paeoniae rubra：For ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall. or river radix paeoniae rubra Paeonia The dry root of veitchii Lynch.Nature and flavor：Hardship is slightly cold.Return liver warp.Effect：Removing blood stasis and analgesics, clearing heat and cooling blood, detumescence.For Febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea, abdominal mass abdominal pain, injury from falling down, carbuncle swells sore.This product Hardship drop, there is the effect of invigorate blood circulation, San Yu Xiao wei, row stagnation pain.Often match moutan bark.For warm heat disease heat invading xuefen, this product is bitter Cold, master enters Liver Channel, is apt to walk blood system, energy clearing away the liver-fire has cool blood, hemostasis, the work(for dissipating stagnation resolvation spot except blood system is hot and suffocating.

Radix Paeoniae Alba：For the dry root of dicotyledon ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall..Property Taste：Cool, picric acid is slightly cold.Effect：It enriches blood soft liver, smooth liver and relieve pain, holds back and cloudy receive sweat.Research shows that：The Paeoniflorin contained in Radix Paeoniae Alba has Antibacterial, improves myocardial nutritional flow, expansion blood vessel, confrontation acute myocardial ischemia, suppression at antipyretic, anti-inflammatory, increase coronary flow Platelet aggregation processed, calmness, analgesia, spasmolysis, antiulcer, the effect for adjusting blood glucose.Radix Paeoniae Alba decoction can inhibit shigella dysenteriae, pneumonia Streptococcus, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc..This product energy nourishing the liver blood, hold back liver-yin, suppression liver-yang, Dispersing liver-energy, and contraction urgency can be delayed, relieved the pain bitterly, to treat the good medicine of the various pain of Liver Channel.

Moutan bark：For the dry root skin of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor： Hardship, it is cool.The thoughts of returning home, liver, kidney, lung channel.Effect：Clearing heat and cooling blood, promoting blood circulation to remove blood stasis.Moutan bark and radix paeoniae rubra energy clearing heat and cooling blood, promoting blood circulationization The stasis of blood enters blood system with warm heat disease is controlled.The power of moutan bark cool blood is stronger, point real heat that can purify the blood and controls fever due to yin deficiency, radix paeoniae rubra promoting blood circulation Work(relatively win, the kind pain controlled caused by extravasated blood.This product cold nature can be sought clearly point, blood system real heat, there is the work(of cooling blood and hemostasis, and Moutan bark is pungent cold, is apt into blood system, can cool blood dissipate the stasis of blood to stop blooding and invigorate blood circulation, the kind blood-head stasis of blood of leading to is stagnant, often with radix rehmanniae recen, red Chinese herbaceous peony is the same as use.For diseases such as sore and toxic, acute appendicitis, this product is also common drug.Treat sore carbuncle can coordinate heat-clearing and detoxifying drug such as Fructus Forsythiae, Bunge Corydalis Herb etc；Controlling acute appendicitis, person can equally use with rheum officinale from the beginning of failing purulence.This product by clearing heat and cooling blood, promoting blood circulation to remove blood stasis with the carbuncle that disappears, Can be used for acute appendicitis and carbuncle sore tumefacting virus, acute appendicitis initial stage can compatibility rheum officinale, can also match the heat-clearing and fire-reducings such as honeysuckle, Fructus Forsythiae.

Eclipta：For the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..Nature and flavor：It is sweet, sour, It is cold.Return kidney, Liver Channel.Effect：It is nourishing liver and kidney, cooling blood and hemostasis.For tooth mobility, poliosis, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, traumatic hemorrhage.

Asian puccoon：For comfrey Asian puccoon（Gromwell root）（Lithosper-mum erythorhizon sieb. et zucc.）And lithospermum euchromum Royle（Radix macrotomiae）[Arnebia euchroma（Royle）Johnst. root].Nature and flavor：It is cold, sweet, salty.Return Through：Converge to heart and liver channels.Function：Cool blood, promoting blood circulation, promoting eruption of detoxifying.For blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption, sore, wet Rash, scald.Clearing heat and cooling blood is used for measles, pyreticosis ecchymosis, eczema, hematuria, blood strangury, bloody flux, sore, erysipelas, burn, heat Tie constipation.

Cicada slough：It falls off when sprouting wings for the larva of the black grasshopper Cryptotympana pustulata Fabricius of cicada Leather shell.Nature and flavor：It is sweet, cold.Return lung, Liver Channel.Effect：Dispelling wind and heat from the body, promoting eruption be antipruritic, removing nebula, Inflammation Zhijing.This product surname dissipate Hair thoroughly, wind-dispelling heat-dissipating, promoting eruption is antipruritic to can be used for treating measles, eczema etc..

Sophora flower：For the drying flower and alabastrum of legume Chinese scholartree Sophora japonica L..Nature and flavor：Hardship is slightly cold.Return liver, Large intestine channel.Effect：Cooling blood and hemostasis, clearing liver-fire.For having blood in stool, hemorrhoid blood, bloody flux, uterine bleeding, haematemesis, bleeding from five sense organs or subcutaneous tissue, the hot hot eyes of liver, headache Dizziness.

Cornu bubali：For the angle of bovid buffalo Bubalus bubalis Linnaeus.Nature and flavor：Hardship is trembled with fear.The thoughts of returning home, liver Through.Effect：It is clearing heat and detoxicating, cool blood, arresting convulsion.For warm disease high fever, coma and delirium, spot dermexanthesis, hematemesis and epistaxis, infantile convulsion is demented.

Rhizoma nelumbinis：For the loose rhizome of nymphaeaceae plant lotus Nelumbo nucifera G..Nature and flavor：It is flat, sweet, puckery.Channel tropism： Stomach, liver, kidney.Effect：Hemostasis dissipates the stasis of blood.Hemoptysis is controlled, is spitted blood, bleeding from five sense organs or subcutaneous tissue, hematuria is had blood in stool, bloody flux, metrorrhagia.The sweet adstringency of this product is flat, i.e., Energy astringing to arrest bleeding, and energy scattered blood stasis, have the characteristics that the stasis of blood is not stayed in hemostasis, and only the efficacy of a drug is relatively slow, and often work assists hemostasis medicinal.The section of lotus root Portion.It for bleeding from five sense organs or subcutaneous tissue, hemoptysis, spits blood, have blood in stool, hematuria and woman uterine bleeding, having hemostasis to lose blood, person is most appropriate.It is applied alone, or matches 5 drugs appropriate.

Rhizoma imperatae：For the rhizome of grass perennial herb cogongrass Imperata cylindrica.Nature and flavor：It is sweet, It is cold.Return lung, stomach, bladder warp.Effect：Cooling blood and hemostasis, reducing fever and causing diuresis.It spits blood for blood-head, bleeding from five sense organs or subcutaneous tissue, hematuria, pyreticosis polydipsia, Huang Subcutaneous ulcer, oedema, puckery pain of heat gonorrhea；Acute nephritis edema.《Bencao Jingshu》It records：Internal lesion caused by overexertion void is won, Bi Neire, the sweet energy tonifying spleen of lalang grass rhizome, sweet Though then trembling with fear without violating stomach.Gan Hanneng removes interior heat, therefore main internal lesion caused by overexertion void is won.Beneficial spleen is so bowl spares, except heat so QI invigorating, it is sweet can beneficial blood, Blood-head then then close by the stasis of blood, the stasis of blood, close then fever and chills work, cold and cool blood, it is sweet benefit blood, heat go then blood and, and then stagnation resolvation and close logical, general rule fever and chills From only.Difficult urination, due to interior heat, pyrolysis is then just from profit.Leaching person, caused by blood system abnormal heat, cool blood benefit blood, then leaching from More, and visitor's heat of stomach self solves, body fluid it is raw and it is thirsty also only.Blood stored in the liver and main reinforcement, cool liver of enriching blood, then muscle is hard.Blood-head then collapses, Cool blood and blood, then collapse self-healing.Blood-head then absurd row, overflow upper orifices be spit, to cough up, be nosebleed epistaxis, bleeding from the gum, cool blood and blood, then all cards From except.Beneficial spleen bowl spares, diuresis, therefore swollen jaundice of also harnessing the river, and simultaneous reason typhoid fever hiccup.

Hairyvein agrimony：For the aerial part of rose family herbaceos perennial Agrimony Agrimonia pilosa Ledeb.. Nature and flavor：It is bitter, puckery, flat.Converge to heart and liver channels.Effect：Astringing to arrest bleeding, removing toxic substances, stop dysentery, desinsection cut cruel.For hemoptysis, spits blood, controls stream nose Blood has special efficacy, malaria, de-power internal lesion caused by overexertion, carbuncle swells.This product puckery is restrained and mild-natured, no matter cold and heat and asthenia and sthenia goes out blood trouble and can all apply. Blood-head bleeding is treated often with radix rehmanniae recen, the root bark of tree peony with use.

The root bark of white mulberry：For the dry root skin of moraceae plants mulberry Morus alba L..Nature and flavor：It is sweet, it trembles with fear.It is distributed in lung channel.Effect：It rushes down Lung is relievingd asthma, inducing diuresis for removing edema.For dyspnea and cough due to lung-heat, oedema turgor oliguria, appearance skin edema.Lung qi, logical water transfer can drop clearly in this product Road and inducing diuresis for removing edema often match fuling peel, the shell of areca nut is equally used with anasarca, difficult urination, edema of the face person is controlled.

Radix scrophulariae：For the dry root of goatweed radix scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor： It is sweet, bitter, salty, it is slightly cold.Return lung, stomach, kidney channel.Effect：Clearing heat and cooling blood, purging intense heat and detonicating, enriching yin.For：Warm heat disease heat enters ying blood, heat The card of sick impairment of yin.There is the effect of clearing heat and cooling blood, removing toxic substances enriching yin.

Licorice：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix The drying root and rhizome of Glycyrrhiza Inflata Bat. or glycyrrhiza glabra Glycyrrhiza Glabra L..Nature and flavor： Sweet and neutral.The thoughts of returning home, lung, spleen, stomach.Effect：Tonifying spleen and stomach, Yiqi and vein recovery.《Japan hanako materia medica》：Peace soul determines soul.Mend the exhaustion or lesion of the five internal organs seven Wound, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, strengthening the essence foster the spirit of nobility, strengthen the bone, and solution is cold and hot.

The present invention square solution be：Radix Astragali tonifying Qi and lifting yang, regulating fluid apssage in side, honeysuckle is clearing heat and detoxicating, wind-dispelling heat-dissipating, Pu Gong English is clearing heat and detoxicating, dispersing swelling and dissipating binds, it is windproof expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, radix rehmanniae recen clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, root bark of shaggy-fruited dittany heat-clearing Eliminating dampness, dispelling wind and arresting itching, the above Six-element are monarch drug in a prescription altogether, and fundamentally scholar supports kidney to Radix Astragali, controls the development of the state of an illness, prevents from involving it His internal organs, honeysuckle, dandelion are clearing heat and detoxicating, wind-dispelling heat-dissipating, can effectively treat chronic nephritis, also there is broad-spectrum antiseptic to make With preventing the recurrence repeatedly of inflammation, other several tastes, clearing heat and cooling blood can treat blood stasis, the wind-heat etc. caused by anaphylactoid purpura Symptom.Fruit of summer cypress clearing heat and promoting diuresis, dispelling wind and arresting itching, Chinese angelica blood supplementing promoting blood circulation, radix scutellariae heat-clearing and damp-drying drug, purging intense heat and detonicating, radix paeoniae rubra removing blood stasis and analgesics, Radix Paeoniae Alba is enriched blood soft liver, smooth liver and relieve pain, and moutan bark clearing heat and cooling blood, promoting blood circulation to remove blood stasis, eclipta, Asian puccoon are nourishing liver and kidney, cooling blood and hemostasis, with Upper eight taste is ministerial drug altogether, while increasing monarch drug in a prescription drug effect, moreover it is possible to which other are concurrent caused by the purpuric renal damage of Reduce allergy Disease.Cicada slough dispelling wind and heat from the body, promoting eruption are antipruritic, and sophora flower cooling blood and hemostasis, clearing liver-fire, cornu bubali is clearing heat and detoxicating, rhizoma nelumbinis hemostasis stasis, in vain Lalang grass rhizome reducing fever and causing diuresis, hairyvein agrimony astringing to arrest bleeding, root bark of white mulberry inducing diuresis for removing edema, radix scrophulariae clearing heat and cooling blood, purging intense heat and detonicating, above several tastes are altogether Adjutant is started with from many aspects, and nourishing patient kidney, spleen, lung three are dirty, and to improve cure rate, licorice coordinating the drug actions of a prescription, priming is returned Through to make medicine.This side's all medicines share, the monarch and his subjects pull together, assistant make it is auxiliary altogether, have clearing heat and detoxicating, tonifying Qi and lifting yang, nourishing Yin and promoting production of body fluid, dissipate the stasis of blood The effect of analgesic, can effectively treat anaphylactoid purpura renal damage.

Medicine material dosage of the present invention is largely groped summary through inventor's progress and is obtained, each raw material dosage is following Parts by weight range all has having a better effect：45-55 parts of Radix Astragali, 10-20 parts of honeysuckle, 13-23 parts of dandelion, windproof 4-14 Part, 15-25 parts of radix rehmanniae recen, 7-17 parts of the root bark of shaggy-fruited dittany, 10-20 parts of the fruit of summer cypress, 10-20 parts of Radix Angelicae Sinensis, 7-17 parts of radix scutellariae, radix paeoniae rubra 7-17 Part, 10-20 parts of Radix Paeoniae Alba, 7-17 parts of moutan bark, 10-20 parts of eclipta, 7-17 parts of Asian puccoon, 3-9 parts of cicada slough, 4-14 parts of sophora flower, water 13-23 parts of ox horn, 7-17 parts of rhizoma nelumbinis, 15-25 parts of rhizoma imperatae, 19-29 parts of hairyvein agrimony, 7-17 parts of the root bark of white mulberry, 7-17 parts of radix scrophulariae, life 3-9 parts of Radix Glycyrrhizae.

Wherein it is preferably：50 parts of Radix Astragali, 15 parts of honeysuckle, 18 parts of dandelion, 9 parts windproof, 20 parts of radix rehmanniae recen, the root bark of shaggy-fruited dittany 12 Part, 15 parts of the fruit of summer cypress, 15 parts of Radix Angelicae Sinensis, 12 parts of radix scutellariae, 12 parts of radix paeoniae rubra, 15 parts of Radix Paeoniae Alba, 12 parts of moutan bark, 15 parts of eclipta, Asian puccoon 12 parts, it is 6 parts of cicada slough, 9 parts of sophora flower, 18 parts of cornu bubali, 12 parts of rhizoma nelumbinis, 20 parts of rhizoma imperatae, 24 parts of hairyvein agrimony, 12 parts of the root bark of white mulberry, profound Join 12 parts, 6 parts of licorice.

The conventional method that Chinese medicine preparation may be used in drug of the present invention is prepared into any conventional oral preparations, and such as pill dissipates Agent, tablet, oral solution etc..Such as these bulk pharmaceutical chemicals can be smashed to be uniformly mixed and powder is made take after mixing it with water；Decocting can be used, Through filtering to get filtrate, preservative is added, oral solution is made；Decoction can also be directly taken when necessary.

Currently preferred preparation method is decoction, and preparation method is as follows：

Step 1：By weight proportion of the present invention, Radix Astragali, windproof, radix rehmanniae recen, the root bark of shaggy-fruited dittany, Radix Angelicae Sinensis, radix scutellariae, radix paeoniae rubra, white is weighed Chinese herbaceous peony, moutan bark, Asian puccoon, rhizoma imperatae, the root bark of white mulberry, radix scrophulariae, which are put into marmite, is added cold water, is more than 3-6 centimetres of powder, decocts with high heat After boiling, switch to be cooked by slow fire 20-30 minutes, filter, obtain filtrate, 3-4 centimetres of water is added in the remaining dregs of a decoction, it is public that Pu is added English, the fruit of summer cypress, eclipta, hairyvein agrimony and the rhizoma nelumbinis bound up with gauze decoct 20-30 minutes, are eventually adding gold and silver lake, Chinese scholartree Flower, licorice decoct 15 minutes, filtering, obtain filtrate, filtrate, waste are spare twice for merging；

Step 2：By weight proportion of the present invention, weigh cicada slough, cornu bubali is ground crushing, cross 180 mesh sieve, it is spare；

Step 3：Fine powder obtained by step 2 is added in liquid obtained by step 1 and be uniformly mixed, both institute of the present invention The traditional Chinese herbal decoction for the treatment anaphylactoid purpura renal damage stated, decoction are taken in two divided doses, once in the morning and once at night, warmly take.

Drug of the present invention is clearing heat and detoxicating, tonifying Qi and lifting yang, nourishing Yin and promoting production of body fluid, removing blood stasis and analgesics and other effects, and significant in efficacy, and price is low It is honest and clean, it has no toxic side effect, treating both manifestation and root cause of disease is counted according to clinical 80 patient views, always effective using one course for the treatment of of drug of the present invention Rate 85%, two course for the treatment of total effective rates 96.25%.

Specific implementation mode

Embodiment one, 45 parts of Radix Astragali, 10 parts of honeysuckle, 13 parts of dandelion, 4 parts windproof, 15 parts of radix rehmanniae recen, 7 parts of the root bark of shaggy-fruited dittany, 10 parts of the fruit of summer cypress, 10 parts of Radix Angelicae Sinensis, 7 parts of radix scutellariae, 7 parts of radix paeoniae rubra, 10 parts of Radix Paeoniae Alba, 7 parts of moutan bark, 10 parts of eclipta, 7 parts of Asian puccoon, cicada Slough off 3 parts, 4 parts of sophora flower, 13 parts of cornu bubali, 7 parts of rhizoma nelumbinis, 15 parts of rhizoma imperatae, 19 parts of hairyvein agrimony, 7 parts of the root bark of white mulberry, 7 parts of radix scrophulariae, life it is sweet 3 parts of grass.

Embodiment two, 50 parts of Radix Astragali, 15 parts of honeysuckle, 18 parts of dandelion, 9 parts windproof, 20 parts of radix rehmanniae recen, the root bark of shaggy-fruited dittany 12 Part, 15 parts of the fruit of summer cypress, 15 parts of Radix Angelicae Sinensis, 12 parts of radix scutellariae, 12 parts of radix paeoniae rubra, 15 parts of Radix Paeoniae Alba, 12 parts of moutan bark, 15 parts of eclipta, Asian puccoon 12 parts, it is 6 parts of cicada slough, 9 parts of sophora flower, 18 parts of cornu bubali, 12 parts of rhizoma nelumbinis, 20 parts of rhizoma imperatae, 24 parts of hairyvein agrimony, 12 parts of the root bark of white mulberry, profound Join 12 parts, 6 parts of licorice.

Embodiment three, 55 parts of Radix Astragali, 20 parts of honeysuckle, 23 parts of dandelion, 14 parts windproof, 25 parts of radix rehmanniae recen, the root bark of shaggy-fruited dittany 17 Part, 20 parts of the fruit of summer cypress, 20 parts of Radix Angelicae Sinensis, 17 parts of radix scutellariae, 17 parts of radix paeoniae rubra, 20 parts of Radix Paeoniae Alba, 17 parts of moutan bark, 20 parts of eclipta, Asian puccoon 17 parts, it is 9 parts of cicada slough, 14 parts of sophora flower, 23 parts of cornu bubali, 17 parts of rhizoma nelumbinis, 25 parts of rhizoma imperatae, 29 parts of hairyvein agrimony, 17 parts of the root bark of white mulberry, profound Join 17 parts, 9 parts of licorice.

Here is clinical statistics data of the patient using drug of the present invention：

One, general information

It accepts out-patient 160 for medical treatment, patient is randomly divided into observation group and control group, wherein male 87, women 73, Male to female ratio 1.2：1, average age 12 years old, the course of disease several natural spans of life to some months etc..Two groups of patient ages, gender, courses of disease etc. are each Item basic document is essentially identical, no significant difference（P ＞ 0.05）.

Two, therapy：

1, observation group weighs bulk pharmaceutical chemicals according to Medications Example two of the present invention and preferred preparation method（Agent on the one Amount）, filter and remove residue after decocting, once a dose sooner or later, warmly takes.15 days as a treatment course.

2, control group treats anaphylactoid purpura renal damage using conventional western medicine, and the observation period is 15 days.

Three, efficacy assessment standard

1, it cures：Clinical symptoms, sign completely disappear, and renal function and routine urinalysis are shown normally；

2, it improves：Clinical symptoms, every sign and complication disappear substantially, and renal function, routine urinalysis have slight exception；

3, it is not cured：Clinical symptoms are without any improvement, and indices are without improvement.

Four, observation group's result counts

Control group result counts

Wherein：Total effective rate=cure rate+improvement rate

Use comparative situation the effect of the Chinese medicine preparation two courses for the treatment of, two groups of patients

Treatment total effective rate by comparing two groups of patients can be found that observation group is apparently higher than control group, thus illustrates, Chinese medicine of the present invention has good clinical effectiveness in treatment anaphylactoid purpura renal damage, can effectively improve the cure rate for the treatment of, The pain for mitigating patient, is worth promoting in clinical application.

Model case and curative effect：

Case one, Qiu, man 14 years old, had found that both legs have ecchymosis, petechia before patient's half a year, and chance in urine Foam increases, and after allowing ground hospital to carry out laser therapy, ecchymosis with it disappears, but does not have how long abdomen occurs in patient Pain phenomenon, the phenomenon that reappearing purple plague purpura with it, there is also arthralgia, disease relapse when serious, it is complete that patient goes to hospital to carry out The inspection in face is diagnosed as anaphylactoid purpura renal damage, and patient uses the therapy for wishing to use traditional Chinese medicine, using this hair Made decoction in bright embodiment two, after taking two courses for the treatment of, symptom is substantially reduced by patient, and abdominal pain phenomenon disappears, the spot on leg Also it gradually becoming shallower as, patient continues taking the two courses, and physical symptom is clearly better, and constitution enhancing, patient goes to hospital to check, Renal function and routine urianlysis show that normally patient is to prevent from recurring, and adhere to having taken a course for the treatment of, and weather is good It is good, Effect of follow-up visit by telephone half a year, no relapse, recovery from illness.

Case two, Mr. Wang, male, 10 years old, patient suffered from anaphylactoid purpura renal damage, and abdominal pain is apparent, and with four limbs, waist Abdomen has purple dot, patient parent to seek medicine everywhere, and afterwards using made decoction in the embodiment of the present invention two, patient takes two treatments Cheng Hou, sensory symptoms are substantially reduced, the existing disappearance of purple plague purpura, abdominal pain, and patient continues to take a period of time, and physical condition is completely good Turn, patient goes to hospital to recur, and items check that display is normal, Effect of follow-up visit by telephone half a year, no relapse, recovery from illness.

Case three, Yuan, female, 15 years old, patient had found that purple plague purpura occurs in leg, goes to hospital to check a few months ago, is diagnosed as Sensitive purpura renal damage, patient use made decoction in the embodiment of the present invention two, after taking two courses for the treatment of patient purple plague purpura phenomenon It is substantially reduced, continue to take a course for the treatment of physical condition improving completely, patient goes to hospital to check, and indices are shown normally, It Effect of follow-up visit by telephone half a year, does not recur, fully recovers.

Claims (3)

1. a kind of Chinese medicine preparation for treating anaphylactoid purpura renal damage, which is characterized in that the Chinese medicine preparation is by following weight The drug composition of part：45-55 parts of Radix Astragali, 10-20 parts of honeysuckle, 13-23 parts of dandelion, 4-14 parts windproof, radix rehmanniae recen 15-25 Part, 7-17 parts of the root bark of shaggy-fruited dittany, 10-20 parts of the fruit of summer cypress, 10-20 parts of Radix Angelicae Sinensis, 7-17 parts of radix scutellariae, 7-17 parts of radix paeoniae rubra, 10-20 parts of Radix Paeoniae Alba, 7-17 parts of moutan bark, 10-20 parts of eclipta, 7-17 parts of Asian puccoon, 3-9 parts of cicada slough, 4-14 parts of sophora flower, 13-23 parts of cornu bubali, rhizoma nelumbinis 7-17 parts, 15-25 parts of rhizoma imperatae, 19-29 parts of hairyvein agrimony, 7-17 parts of the root bark of white mulberry, 7-17 parts of radix scrophulariae, 3-9 parts of licorice.

2. the Chinese medicine preparation for the treatment of anaphylactoid purpura renal damage according to claim 1, which is characterized in that by following The drug of parts by weight forms：50 parts of Radix Astragali, 15 parts of honeysuckle, 18 parts of dandelion, 9 parts windproof, 20 parts of radix rehmanniae recen, the root bark of shaggy-fruited dittany 12 Part, 15 parts of the fruit of summer cypress, 15 parts of Radix Angelicae Sinensis, 12 parts of radix scutellariae, 12 parts of radix paeoniae rubra, 15 parts of Radix Paeoniae Alba, 12 parts of moutan bark, 15 parts of eclipta, Asian puccoon 12 parts, it is 6 parts of cicada slough, 9 parts of sophora flower, 18 parts of cornu bubali, 12 parts of rhizoma nelumbinis, 20 parts of rhizoma imperatae, 24 parts of hairyvein agrimony, 12 parts of the root bark of white mulberry, profound Join 12 parts, 6 parts of licorice.

3. the Chinese medicine preparation for the treatment of anaphylactoid purpura renal damage according to claim 1 or 2, it is characterised in that：It is described Chinese medicine preparation is decoction.