CN109464565A - A kind of Chinese medicine composition and its preparation for treating chest impediment and cardialgia - Google Patents
A kind of Chinese medicine composition and its preparation for treating chest impediment and cardialgia Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition for treating chest impediment and cardialgia, by peach kernel, safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, pheretima, Fructus Aurantii, rhizoma cyperi, dried orange peel, Radix Salviae Miltiorrhizae, cortex cinnamomi and illiciumverum；Chinese medicine composition of the invention is prepared by several kinds of Chinese medicinal materials, and safety is mild, minimum to human body side effect, has the effect of regulating qi-flowing for eliminating phlegm, temperature leads to promoting blood circulation and stopping pain, peach kernel blood-breaking row is stagnant and moisturizes, and safflower promoting blood circulation is to relieve pain；Chinese angelica blood supplementing promoting blood circulation, Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping help peach kernel and safflower promoting blood circulation altogether, ensuring proper downward flow of the blood；Pheretima, Fructus Aurantii, rhizoma cyperi, dried orange peel, Radix Salviae Miltiorrhizae, cortex cinnamomi, octagonal blood-nourishing benefiting yin, and can invigorate blood circulation, all medicines share, altogether at regulating qi-flowing for eliminating phlegm, the agent of the logical promoting blood circulation and stopping pain of temperature.Effectively treatment chest impediment and cardialgia, especially phlegm-stasis in channels type chest impediment and cardialgia.In addition, Traditional Chinese medicine composition formula of the invention is scientific and reasonable, Small side effects, preparation method is simple, and preparation cost is low, can mitigate body and the financial burden of patient significantly, has very big promotional value.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of Chinese medicine composition and its preparation for treating chest impediment and cardialgia.
Background technique
Chest impediment and cardialgia refers to a kind of disease that suffocating pain over the chest or even chest pain radiating to the back are died, failing to sleep due to dyspnea is primary symptom.Less serious case
Only feel uncomfortable in chest such as to stop up, breathe and owe smooth, severe one then has a pectoralgia, and serious person chests pain radiating to the back, backache radiating to the heart.With modern society's life
The change of mode and dietary structure, morbidity has the tendency that gradually increasing, thus this disease increasingly attracts people's attention.
The clinical Common Syndromes type of chest impediment and cardialgia has syndrome of qi deficiency of heart and lung, phlegm-stasis in channels, and deficiency of heart-QI is demonstrate,proved, deficiency of heart-blood card,
Syndrome of disharmony between heart and kidney etc..What the present invention mainly studied is one of clinical common card type-phlegm-stasis in channels type chest impediment and cardialgia.The card type
System is because of phlegm stagnation in collateral, chest impediment and cardialgia caused by blood fortune is unsmooth, there is the characteristics of pained as pierced, fixed pain, is often accompanied by that tongue is dim to be had
The symptoms such as ecchymosis, tongue fur are thin, deep thready pulse is puckery.
Since chest impediment and cardialgia shows as asthenia in origin and asthenia in superficiality, there are complicated Linchuan performance and pathological change, and traditional Chinese medicine is treated
From entirety, the advantage with comprehensive function, thus widely paid close attention to.
Summary of the invention
It is an object of the invention to overcome defect of the existing technology, a kind of Chinese traditional medicine composition for treating chest impediment and cardialgia is provided
Object and its preparation.
To achieve the goals above, The technical solution adopted by the invention is as follows:
The Chinese medicine composition for the treatment of chest impediment and cardialgia of the invention, is prepared: peach kernel 5- by the raw material of following parts by weight
15 parts, 1-5 parts of safflower, 2-8 parts of Radix Angelicae Sinensis, 2-9 parts of Rhizoma Chuanxiong, 2-8 parts of pheretima, 2-8 parts of Fructus Aurantii, 2-8 parts of rhizoma cyperi, 1-6 parts of dried orange peel, pellet
Join 4-12 parts, 2-8 parts of cortex cinnamomi, 0.5-5 parts of illiciumverum.
Preferably, it is prepared by the raw material of following parts by weight: 9 parts of peach kernel, 3 parts of safflower, 5 parts of Radix Angelicae Sinensis, Rhizoma Chuanxiong 4.5
Part, 5 parts of pheretima, 5 parts of Fructus Aurantii, 5 parts of rhizoma cyperi, 3 parts of dried orange peel, 7.5 parts of Radix Salviae Miltiorrhizae, 4 parts of cortex cinnamomi, 1.5 parts of illiciumverum.
It is the crude drug source of the traditional chinese medicine composition of the invention below:
Peach kernel is rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana
(Carr.) dry mature seed of Franch..Bitter, sweet, flat.Promoting blood circulation, relax bowel and defecation.For menostasis, dysmenorrhea , wei lump in the abdomen ruffian
Block, injury from falling down, dry constipation of intestines.
Safflower is compositae plant safflower, pungent, warm.Blood circulation, scattered silt analgesic, is used for amenorrhoea, dysmenorrhea, lochia, disease
Lump in the abdomen lump in the abdomen, traumatic injury, hemorrhoid gall.
Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Sweet, acrid, warm.
Replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia,
Dry constipation of intestines, rheumatic arthralgia, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia is fallen and is flutterred
Damage.
Rhizoma Chuanxiong is umbelliferae Rhizoma Chuanxiong Ligusticum chuanxiong Hort. (or Ligusticum
Wallichii Franch.) dry rhizome.It is acrid in flavour and warm in nature.Blood-activating and qi-promoting, wind-expelling pain-stopping.For irregular menstruation, amenorrhea and algomenorrhea, disease
Lump in the abdomen abdominal pain, pricking pain in the chest, tumbling and swelling, headache, rheumatic arthralgia.
Pheretima is Ju Yin section animal Pheretima aspergillum Pheretima aspergillum (E.Perrier), popular Pheretimatschiliensis
Pheretimavulgaris Chen, power simulation Pheretima guillelmi (Michaelsen) or the blind Pheretimatschiliensis of comb
The hirudo leech of PheretimapectiniferaMichaelsen.It is salty, it trembles with fear.Heat-clearing arresting convulsion, dredging collateral are relievingd asthma, diuresis.For high fever
Coma, twitch, arthralgia, extremity numbness, hemiplegia, dyspnea and cough due to lung-heat, oliguria oedema, hypertension.
Fructus Aurantii is the drying immature fruit of rutaceae bitter orange Citrus aurantium L. and its variety.
Bitter, acid, slightly cold channel tropism, lung, spleen, liver, stomach, large intestine channel.There is the effect of regulating the flow of QI to ease the stomach, row stagnant dissipate-swelling, be used for the chest side of body stagnation of the circulation of vital energy, it is swollen
Full pain, accumulation of food in the stomach and intes tine due to indigestion stop in phlegm retention, gastroptosis, rectal prolapse, sub-official prolapses.
Rhizoma cyperi is the dry rhizome of sedge nutgrass flatsedge Cyperus rotundus L..Pungent, slight bitter, micro- sweet and neutral.Row
Gas relieve stagnation, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian, cold hernia stomachache, spargosis
Bitterly, irregular menstruation, amenorrhea and algomenorrhea.
Dried orange peel is the dry mature skin of rutaceae orange Citrus reticulataBlanco and its variety.
It is pungent, bitter, temperature.Returns spleen, stomach, lung channel.With regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, the effect of resolving sputum.Stomach duct and abdomen for the taste stagnation of the circulation of vital energy is swollen
Full or pain, indigestion, abdominal distension uncomfortable in chest, cough and asthma, chest gastral cavity turgor, deficiency of food are vomited and diarrhoea, coughing with a lot of sputum.
Radix Salviae Miltiorrhizae is the dry root and rhizome of Lamiaceae plant Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Hardship, it is slightly cold.Return
The heart, Liver Channel.It is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness and restlessness, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, stomach duct and abdomen hypochondriac pain,
The accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea menostasis, sore swell and ache curative.
Cortex cinnamomi is the dry bark of lauraceae plant cortex cinnamomi Cinnamomum cassia Presl.It is pungent, sweet, big heat.Mend fire
It is supporing yang, let the fire back to its origin, eliminating cold to stop pain, blood circulation.For impotence, palace cold, waist and knee crymodynia, kidney deficiency characterized by dyspnea, dizziness due to yang deficiency, hot eyes
Pharyngalgia, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold hernia, renal mass, menostasis, dysmenorrhea.
Illiciumverum is the dry mature fruit of Magnoliacea plant Chinese anise Illicium verum Hook.f..It is acrid in flavour and warm in nature.
Warming yang for dispelling cold, regulating qi-flowing for relieving pain.For cold hernia stomachache, lumbago due to the kidney deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.
It is a further object of the present invention to provide the preparation method of the active constituent of the traditional chinese medicine composition of the invention, this method is to adopt
It is mentioned with water or the extraction of the ethyl alcohol of 40-70% concentration expressed in percentage by volume is prepared.It is specific the preparation method is as follows:
Scheme one: taking whole medicinal materials, and extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, combined extract, filtering, and relative density is 1.10- when filtrate is concentrated 70-80 DEG C
1.20 clear cream is to get active constituent.
Scheme two: taking whole medicinal materials, is extracted 2-3 times after mixing with 40-70% alcohol reflux, and each ethanol consumption is medicinal material
4-10 times of total weight, extraction time are 1-4 hours, combined extract, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For 1.05-1.20 clear cream to get active constituent.
Scheme three: taking whole medicinal materials, and extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, combined extract, filtering, and relative density is 1.10- when filtrate is concentrated into 70-80 DEG C
Ethyl alcohol is added in 1.20 clear cream, makes alcohol content 40-70%, stands 12-24 hours, filtering, when filtrate is concentrated into 70-80 DEG C
Relative density is the medicinal extract of 1.05-1.20 to get active constituent.
The Chinese medicine composition for the treatment of chest impediment and cardialgia of the present invention, can also match with pharmaceutically acceptable carrier
It closes, various preparations, such as tablet, capsule, oral solution, syrup, mixture, granule is made.
Pharmaceutically acceptable carrier of the invention includes but is not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive: purified water, ethyl alcohol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrating agent: starch, sodium carboxymethyl starch, cellulose derivative, crospovidone etc..
Lubricant: magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent: water, ethyl alcohol, glycerol, propylene glycol, liquid paraffin, vegetable oil etc..
Corrigent: sucrose, monosaccharide, aromatic etc..
Preservative: benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1: tablet
It takes scheme one one of to three gained active constituent of scheme, tablet is added and often uses auxiliary material, routinely prepared by production method
Obtain Tablets.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 2: capsule
It takes scheme one one of to three gained active constituent of scheme, capsule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 3: syrup
It takes scheme one one of to three gained active constituent of scheme, syrup is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain syrup of the present invention.
Above-mentioned syrup often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 4: mixture
It takes scheme one one of to three gained active constituent of scheme, mixture is added and often uses auxiliary material, routinely prepared by production method
Obtain mixture of the present invention.
Above-mentioned mixture often includes one of corrigent, preservative or whole with auxiliary material.
Method 5: oral solution
Take scheme one one of to three gained active constituent of scheme, dissolution after-purification, concentration are added oral solution and often use auxiliary material,
Routinely production method is prepared into oral solution of the present invention.
Above-mentioned oral solution often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 6: granule
It takes scheme one one of to three gained active constituent of scheme, granule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain granule of the present invention.
Above-mentioned granule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
The applicant combines Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation and modern pharmacological research achievement to base oneself upon by many years development test
The Chinese medical discrimination of " chest impediment and cardialgia " is theoretical, compares multiple formulations, obtains by peach kernel, safflower, Radix Angelicae Sinensis, Rhizoma Chuanxiong, pheretima, Fructus Aurantii, perfume (or spice)
The Chinese medicine composition of the medicinal materials such as attached, dried orange peel, Radix Salviae Miltiorrhizae, cortex cinnamomi, illiciumverum composition, has the effect of regulating qi-flowing for eliminating phlegm, temperature leads to promoting blood circulation and stopping pain,
For phlegm-stasis blocking collateral type chest impediment and cardialgia.For Chinese medicine composition of the invention using peach kernel, safflower as monarch drug in a prescription, peach kernel blood-breaking row is stagnant and moistens
Dry, safflower promoting blood circulation is to relieve pain；Radix Angelicae Sinensis, Rhizoma Chuanxiong are ministerial drug, and Chinese angelica blood supplementing is invigorated blood circulation, and Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping helps altogether
Monarch drug in a prescription promoting blood circulation, ensurings proper downward flow of the blood；Pheretima, Fructus Aurantii, rhizoma cyperi, dried orange peel, Radix Salviae Miltiorrhizae, cortex cinnamomi, illiciumverum make for assistant, blood-nourishing benefiting yin, and energy
Promoting blood circulation, all medicines share, altogether at regulating qi-flowing for eliminating phlegm, the agent of the logical promoting blood circulation and stopping pain of temperature.Effectively treatment chest impediment and cardialgia, especially phlegm-stasis in channels
Type chest impediment and cardialgia.
The present invention is by adopting the above-described technical solution, have the advantages that
(1) Chinese medicine composition of the invention and its preparation are prepared by several kinds of Chinese medicinal materials, and safety is mild, are made to human body pair
With minimum, there is regulating qi-flowing for eliminating phlegm, the effect of temperature logical promoting blood circulation and stopping pain, peach kernel blood-breaking row is stagnant and moisturizes, and safflower promoting blood circulation is to relieve pain；
Chinese angelica blood supplementing promoting blood circulation, Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping help peach kernel and safflower promoting blood circulation altogether, ensuring proper downward flow of the blood；Pheretima, Fructus Aurantii,
Rhizoma cyperi, dried orange peel, Radix Salviae Miltiorrhizae, cortex cinnamomi, octagonal blood-nourishing benefiting yin, and can invigorate blood circulation, all medicines share, altogether at regulating qi-flowing for eliminating phlegm, the logical promoting blood circulation and stopping pain of temperature
Agent.Effectively treatment chest impediment and cardialgia, especially phlegm-stasis in channels type chest impediment and cardialgia.It organically combines the above various raw materials one
Rise, it is mutually coordinated between each ingredient, interaction, to chest impediment and cardialgia can treating both manifestation and root cause of disease, work well, fundamentally treat this
Illness.
(2) Chinese medicine composition of the invention and its preparation clinical tests prove that, to syndrome of qi deficiency of heart and lung type chest impediment and cardialgia
Cure rate is 63.64%, total effective rate 95.45%, and the cure rate to phlegm-stasis in channels type chest impediment and cardialgia is 77.14%, always
Effective percentage is 97.14%, and the cure rate to deficiency of heart-QI card type chest impediment and cardialgia is 57.14%, and total effective rate 95.24% is right
The cure rate of deficiency of heart-blood card type chest impediment and cardialgia is 68.42%, total effective rate 94.74%, to the syndrome of disharmony between heart and kidney type thoracic obstruction heart
The cure rate of pain is 61.11%, total effective rate 94.44%.Total cure rate to various types chest impediment and cardialgia is 69.33%,
Total effective rate is 96.00%, and therapeutic effect is significant.
(3) several formulations are made in Chinese medicine composition of the invention, take, is easy to carry, meet the sufferer clothes of the different patient's condition
With and carry, wide application of the crowd.
(4) Chinese medicine composition of the invention and its pharmaceutical formulation are scientific and reasonable, and Small side effects, preparation method is simple, preparation
It is at low cost, body and the financial burden of patient can be mitigated significantly, there is very big promotional value.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention more comprehensible, preferred embodiment is enumerated below, to this hair
Bright further description.However, it is necessary to illustrate, many details listed in specification are used for the purpose of making reader to this
The one or more aspects of invention have a thorough explanation, also may be implemented even without these specific details of the invention
These aspects.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v indicates the volume of solution
Than.
1 tablet of embodiment
Weigh peach kernel 5kg, safflower 1kg, Radix Angelicae Sinensis 2kg, Rhizoma Chuanxiong 2kg, pheretima 2kg, Fructus Aurantii 2kg, rhizoma cyperi 2kg, dried orange peel 1kg,
Radix Salviae Miltiorrhizae 4kg, cortex cinnamomi 2kg, illiciumverum 0.5kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 9 times, and two
Secondary extraction time is respectively 3 hours, 2 hours, combined extract, filtering, when filtrate is concentrated 70 DEG C relative density be 1.10 it is clear
Additive of tablet starch, ethyl alcohol, crospovidone, magnesium stearate is added in cream, and routinely tablet is made in scheme.
2 tablet of embodiment
Weigh peach kernel 6kg, safflower 1.5kg, Radix Angelicae Sinensis 2.8kg, Rhizoma Chuanxiong 2.5kg, pheretima 2.7kg, Fructus Aurantii 2.5kg, rhizoma cyperi
2.8kg, dried orange peel 1.6kg, Radix Salviae Miltiorrhizae 5kg, cortex cinnamomi 2.6kg, illiciumverum 1kg；
Whole medicinal materials are taken, are extracted 3 times after mixing with 40% alcohol reflux, each ethanol consumption is the 10 of medicinal material total weight
Again, 7 times, 5 times, extraction time is respectively 4 hours, 6 hours, 1 hour three times, and combined extract filters, and filtrate is concentrated into 70 DEG C
When relative density be 1.05 clear cream, be added additive of tablet dextrin, gelatin, starch, talcum powder, routinely scheme be made tablet.
3 capsule of embodiment
Weigh peach kernel 7kg, safflower 2kg, Radix Angelicae Sinensis 3.5kg, Rhizoma Chuanxiong 3.2kg, pheretima 3.2kg, Fructus Aurantii 3kg, rhizoma cyperi 3.3kg,
Dried orange peel 2.2kg, Radix Salviae Miltiorrhizae 6kg, cortex cinnamomi 3.3kg, illiciumverum 1.5kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 8 times, often
Secondary extraction time is respectively 3 hours, 2 hours, and combined extract, filtering, relative density is 1.10 when filtrate is concentrated into 70 DEG C
Ethyl alcohol is added in clear cream, makes alcohol content 40%, stands 12 hours, filtering, and relative density is 1.05 when filtrate is concentrated into 70 DEG C
Capsule auxiliary material lactose, polyethylene glycol, cellulose derivative, superfine silica gel powder, vegetable oil is added in medicinal extract, and routinely scheme is made
Capsule.
4 capsule of embodiment
Weigh peach kernel 8kg, safflower 2.5kg, Radix Angelicae Sinensis 3.2kg, Rhizoma Chuanxiong 3.9kg, pheretima 3.8kg, Fructus Aurantii 3.6kg, rhizoma cyperi
3.8kg, dried orange peel 2.8kg, Radix Salviae Miltiorrhizae 7kg, cortex cinnamomi 4kg, illiciumverum 2kg；
Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to 9 times of medicinal material total weight, 8 times, 6 times,
Each extraction time is respectively 3 hours, 2 hours, 1 hour, and combined extract, filtering, relative density is when filtrate is concentrated 75 DEG C
1.16 clear cream, in clear cream be added capsule microcrystalline cellulose excipients, starch, polyethylene glycol, glycerol, routinely scheme be made
Capsule.
5 syrup of embodiment
Weigh peach kernel 15kg, safflower 5kg, Radix Angelicae Sinensis 8kg, Rhizoma Chuanxiong 9kg, pheretima 8kg, Fructus Aurantii 8kg, rhizoma cyperi 8kg, dried orange peel 6kg,
Radix Salviae Miltiorrhizae 12kg, cortex cinnamomi 8kg, illiciumverum 5kg；
Whole medicinal materials are taken, are extracted 3 times after mixing with 55% alcohol reflux, each ethanol consumption is 8 times of medicinal material total weight,
7 times, 4 times, each extraction time are respectively 3 hours, 2 hours, 1 hour, combined extract, filtering, when filtrate is concentrated into 75 DEG C
The clear cream that relative density is 1.10 is added syrup auxiliary material sucrose, benzoic acid and water in clear cream and stirs evenly, syrup is made
Agent.
6 mixture of embodiment
Weigh peach kernel 10kg, safflower 4kg, Radix Angelicae Sinensis 5.6kg, Rhizoma Chuanxiong 5kg, pheretima 5.5kg, Fructus Aurantii 5.4kg, rhizoma cyperi 5.6kg,
Dried orange peel 3.8kg, Radix Salviae Miltiorrhizae 9kg, cortex cinnamomi 5kg, illiciumverum 3.5kg；
Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to 9 times of medicinal material total weight, 8 times, 6 times,
Each extraction time is respectively 3 hours, 2 hours, 1 hour, combined extract, filtering, relative density when filtrate is concentrated into 75 DEG C
For 1.15 clear cream, ethyl alcohol is added, makes alcohol content 50%, stands 18 hours, filtering, relative density when filtrate is concentrated into 75 DEG C
For 1.12 medicinal extract, mixture auxiliary material aromatic, sorbic acid are added in medicinal extract, stirs evenly, mixture is made.
7 oral solution of embodiment
Weigh peach kernel 12kg, safflower 4.3kg, Radix Angelicae Sinensis 6.2kg, Rhizoma Chuanxiong 7kg, pheretima 6kg, Fructus Aurantii 6.4kg, rhizoma cyperi 6kg, old
Skin 5kg, Radix Salviae Miltiorrhizae 10kg, cortex cinnamomi 6kg, illiciumverum 4kg；
Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to 10 times of medicinal material total weight, 8 times, 6
Times, each extraction time is respectively 3 hours, 1 hour, 1 hour, combined extract, filtering, relative density when filtrate is concentrated 80 DEG C
For 1.20 clear cream, oral solution auxiliary material monosaccharide, methyl esters, water is added in clear cream and stirs evenly, dispenses, oral solution is made.
8 granule of embodiment
Weigh peach kernel 14kg, safflower 4.6kg, Radix Angelicae Sinensis 7kg, Rhizoma Chuanxiong 8kg, pheretima 7kg, Fructus Aurantii 7.2kg, rhizoma cyperi 7kg, dried orange peel
5.5kg, Radix Salviae Miltiorrhizae 11kg, cortex cinnamomi 7kg, illiciumverum 4.5kg；
Whole medicinal materials are taken, are extracted 2 times after mixing with 70% alcohol reflux, each ethanol consumption is 6 times of medicinal material total weight,
4 times, extraction time is respectively 2 hours, 1 hour, and combined extract, filtering, relative density is 1.20 when filtrate is concentrated into 80 DEG C
Clear cream, auxiliary material inorganic salts, lactose, gelatin, talcum powder, ethyl alcohol are added in clear cream, particle is made in granulation, dry, whole grain
Agent.
9 granule of embodiment
Weigh peach kernel 9kg, safflower 3kg, Radix Angelicae Sinensis 5kg, Rhizoma Chuanxiong 4.5kg, pheretima 5kg, Fructus Aurantii 5kg, rhizoma cyperi 5kg, dried orange peel
3kg, Radix Salviae Miltiorrhizae 7.5kg, cortex cinnamomi 4kg, illiciumverum 1.5kg；
Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to 12 times of medicinal material total weight, 6 times, often
Secondary extraction time is 3 hours, 2 hours, and combined extract filters, the clear cream that relative density is 1.20 when filtrate is concentrated into 80 DEG C,
Ethyl alcohol is added, makes alcohol content 70%, stands 24 hours, filtering, the medicinal extract that relative density is 1.20 when filtrate is concentrated into 80 DEG C,
Microcrystalline cellulose excipients, sodium carboxymethyl starch, magnesium stearate, propylene glycol are added in medicinal extract, pelletize, dry, whole grain, obtained
Granula.
Clinical test is summarized
1, basic document
Selection is diagnosed as patient 150 of chest impediment and cardialgia, and male 80, women 70, wherein the oldest person 68 years old, most
Small person 32 years old, average age 42.6 years old, course of disease 1-12.Wherein syndrome of qi deficiency of heart and lung type chest impediment and cardialgia 22, phlegm-stasis in channels type
Chest impediment and cardialgia 70, chest impediment and cardialgia 21, deficiency of heart-QI card type, chest impediment and cardialgia 19, deficiency of heart-blood card type, syndrome of disharmony between heart and kidney type chest
Numbness pained 18.
Exclude gestation and breast feeding women, those who are allergic to this drug, severe cardiac pulmonary dysfunction, non-coronary disease characteristic of disease heart disease,
Kidney trouble, hypertension, stomach patient.
2, curative effect judging standard
It is diagnosed referring to State Administration of Traditional Chinese Medicine's Standards for Diagnosis and Curative Effect of Chinese Medical Symptom.Diagnostic criteria is as follows:
Cure: symptom disappears, and electrocardiogram and related laboratory check and restore normal；
Effective: symptom disappears substantially, and attack times are few, and the intermittent phase extends, and laboratory checks and returns to normal；
Effective: symptom mitigates, and attack times are reduced, and the intermittent phase is extended, and laboratory, which checks, improvement；
Invalid: cardinal symptom and electrocardiogram are without change.
3, treatment method
It is given and is treated using the granule of the embodiment of the present invention 9,2 times a day, each 10g, 14 days as a treatment course.
4, result
By the treatment of 6 courses for the treatment of, clinical efficacy is shown in Table 1.
1 therapeutic effect of table
| Chest impediment and cardialgia type | Healing/example | Significantly/example | Effectively/example | In vain/example | Cure rate/% | Total effective rate/% |
| Syndrome of qi deficiency of heart and lung type | 14 | 4 | 3 | 1 | 63.64 | 95.45 |
| Phlegm-stasis in channels type | 54 | 9 | 5 | 2 | 77.14 | 97.14 |
| Deficiency of heart-QI card type | 12 | 5 | 3 | 1 | 57.14 | 95.24 |
| Deficiency of heart-blood card type | 13 | 4 | 1 | 1 | 68.42 | 94.74 |
| Syndrome of disharmony between heart and kidney type | 11 | 4 | 2 | 1 | 61.11 | 94.44 |
As it can be seen from table 1 the treatment by 6 courses for the treatment of, Chinese medicine composition of the invention is to syndrome of qi deficiency of heart and lung type thoracic obstruction
Pained cure rate is 63.64%, total effective rate 95.45%, and the cure rate to phlegm-stasis in channels type chest impediment and cardialgia is
77.14%, total effective rate 97.14%, the cure rate to deficiency of heart-QI card type chest impediment and cardialgia is 57.14%, and total effective rate is
95.24%, the cure rate to deficiency of heart-blood card type chest impediment and cardialgia is 68.42%, total effective rate 94.74%, to breakdown of the normal physiological coordination between the heart and the kidney
The cure rate of card type chest impediment and cardialgia is 61.11%, total effective rate 94.44%.To the total cure rate of various types chest impediment and cardialgia
It is 69.33%, total effective rate 96.00%, therapeutic effect is significant.It can be seen that the traditional chinese medicine composition of the invention and its preparation can be effective
Various types of chest impediment and cardialgias are treated, it is aobvious to show that the traditional chinese medicine composition of the invention and its preparation have chest impediment and cardialgia by clinical observation
Write curative effect, patient generally can feel that chest impediment and cardialgia is substantially reduced after 1 course for the treatment of of taking medicine, Liver and kidney function to patient and
Hemopoietic system has no abnormal changes and adverse reaction, and " rebounding " does not occur in the state of an illness after drug withdrawal, and clinic is taken securely and reliably.
Typical case
Case 1: king XX, male, 46 years old.
Main suit: two years ago start to feel often right chest it is ictal feel oppressed, pain, and with palpitaition, shortness of breath, unsmooth breath etc.
Symptom.It is diagnosed as phlegm-stasis in channels type chest impediment and cardialgia on inspection.Take the capsule of the embodiment of the present invention 3 more than 1 month, symptom has
Alleviated, continuing to take 4 course for the treatment of rear symptom totally disappeared, and check is cured, and follow-up is not recurred after being discontinued 1 year.
Case 2: X, female, 36 years old.
Main suit: patient 3 years start, and right chest is often accompanied by squeezing sample colic pain, and has ecchymosis with tongue is dim, and tongue fur is thin, and deep thready pulse is puckery
Etc. symptoms, looked into and be diagnosed as phlegm-stasis in channels type chest impediment and cardialgia.1 course for the treatment of of oral solution of the embodiment of the present invention 7 is taken, all diseases subtract
Gently；It even served 1 month again and consolidate curative effect, symptom totally disappeared, and check is cured, and follow-up is not recurred after half a year of being discontinued.
Case 3: old X, male, 66 years old.
Main suit: there is secret anguish often in Danzhong before patient 1 year, sharp ache when serious, and with syndrome characterized by dyspnea, terrified uneasy, face
Color is pale, and cold sweat is looked into from out and is diagnosed as syndrome of qi deficiency of heart and lung type chest impediment and cardialgia, take the tablet of the embodiment of the present invention 12 months,
Symptom is relieved；Continue to take 3 course for the treatment of, symptom totally disappeared, and check is cured, and follow-up is without recurrence after being discontinued 1 year.
Claims (7)
1. a kind of Chinese medicine composition for treating chest impediment and cardialgia, which is characterized in that be prepared by the raw material of following parts by weight: peach
5-15 parts of benevolence, 1-5 parts of safflower, 2-8 parts of Radix Angelicae Sinensis, 2-9 parts of Rhizoma Chuanxiong, 2-8 parts of pheretima, 2-8 parts of Fructus Aurantii, 2-8 parts of rhizoma cyperi, dried orange peel 1-6
Part, 4-12 parts of Radix Salviae Miltiorrhizae, 2-8 parts of cortex cinnamomi, 0.5-5 parts of illiciumverum.
2. the Chinese medicine composition for the treatment of chest impediment and cardialgia according to claim 1, which is characterized in that by the original of following parts by weight
What material was prepared: 9 parts of peach kernel, 3 parts of safflower, 5 parts of Radix Angelicae Sinensis, 4.5 parts of Rhizoma Chuanxiong, 5 parts of pheretima, 5 parts of Fructus Aurantii, 5 parts of rhizoma cyperi, dried orange peel 3
Part, 7.5 parts of Radix Salviae Miltiorrhizae, 4 parts of cortex cinnamomi, 1.5 parts of illiciumverum.
3. the Chinese medicine composition for the treatment of chest impediment and cardialgia according to claim 1 or 2, it is characterised in that: its active constituent
Be using water mention or the ethyl alcohol of 40-70% concentration expressed in percentage by volume extraction be prepared.
4. the Chinese medicine composition for the treatment of chest impediment and cardialgia according to claim 3, which is characterized in that its active constituent is logical
It crosses what following methods were prepared: taking whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time are 1-3 hours, combined extract, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For 1.10-1.20 clear cream to get active constituent.
5. the Chinese medicine composition for the treatment of chest impediment and cardialgia according to claim 3, which is characterized in that its active constituent is logical
It crosses what following methods were prepared: taking whole medicinal materials, extracted 2-3 times after mixing with 40-70% alcohol reflux, each ethanol consumption
It is 4-10 times of medicinal material total weight, extraction time is 1-4 hours, combined extract, filtering, and filtrate is concentrated into 70-80 DEG C of phase
To the clear cream that density is 1.05-1.20 to get active constituent.
6. the Chinese medicine composition for the treatment of chest impediment and cardialgia according to claim 3, which is characterized in that its active constituent is logical
It crosses what following methods were prepared: taking whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time are 1-3 hours, combined extract, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For the clear cream of 1.10-1.20, ethyl alcohol is added, makes alcohol content 40-70%, stands 12-24 hours, filtering, filtrate is concentrated into 70-
Relative density is the medicinal extract of 1.05-1.20 to get active constituent at 80 DEG C.
7. a kind of Chinese materia medica preparation for treating chest impediment and cardialgia, by the Chinese medicine for the treatment of chest impediment and cardialgia described in any one of claims 1-6
Composition is prepared with pharmaceutically acceptable carrier combination.
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| CN111202793A (en) * | 2020-01-18 | 2020-05-29 | 广西壮族自治区中医药研究院 | Traditional Chinese medicine preparation for treating heart blood stasis type chest stuffiness and pains and preparation method thereof |
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