CN106729443A - A kind of Chinese medicine composition for swelling and pain relieving and preparation method thereof - Google Patents

A kind of Chinese medicine composition for swelling and pain relieving and preparation method thereof Download PDF

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CN106729443A
CN106729443A CN201710083093.2A CN201710083093A CN106729443A CN 106729443 A CN106729443 A CN 106729443A CN 201710083093 A CN201710083093 A CN 201710083093A CN 106729443 A CN106729443 A CN 106729443A
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parts
chinese
medicine composition
root
chinese medicine
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梁永新
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Affiliated Hospital of University of Qingdao
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Affiliated Hospital of University of Qingdao
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
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    • A61K36/16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

A kind of Chinese medicine composition for swelling and pain relieving, the bulk drug of the Chinese medicine composition is made up of the rhizome of davallia, sweet wormwood, root of Chinese trichosanthes, paniculate swallowwort, ginkgo leaf, honeysuckle, peppermint, Fructus meliae toosendan, dragon's blood, golden cypress, giant knotweed, lopseed, spina date seed, the root of Dahurain angelica, curcuma zedoary, stir-baked FRUCTUS GARDENIAE, akebi, Chinese gall, rhizoma atractylodis, coix seed, reticulate millettia, cattail pollen, dandelion, levisticum, bush, caulis lonicerae, folium isatidis, bark of ash etc..

Description

A kind of Chinese medicine composition for swelling and pain relieving and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, it is related to a kind of Chinese medicine composition, and in particular to a kind of for swelling and pain relieving Chinese medicine composition and preparation method thereof.
Background technology
Swell and ache, the swelling of body a part tissue and pain caused by the general symptom of dactylitis disease, i.e. damage or inflammation.It is existing Grow directly from seeds it is living in, the accident that bruises and sprains are not easy to avoid as people, bruises and sprains easily give people to cause extravasated blood, swell and ache, muscle acid The consequence such as bitterly, tendon and vessel is obstructed, makes one to feel under the weather, and has a strong impact on life.At present, treatment traumatic injury, detumescence stop on the market Bitterly, activate blood circulation and disperse blood clots, rheumatism swells and ache, the externally used detumescence analgesic type drug species of softening hard masses scattered silt is various, including the analgesic of chemical drug class disappears The alleviating pain and detumescence medicine of swollen medicine and Chinese medicine class, though having certain effect when using, its swelling and pain relieving, promoting blood circulation to remove blood stasis effect are relatively paid no attention to Think.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for swelling and pain relieving and preparation method thereof.
Above-mentioned purpose of the invention is realized by following technical proposals:
A kind of Chinese medicine composition for swelling and pain relieving, the bulk drug of the Chinese medicine composition is by the rhizome of davallia, sweet wormwood, smallpox Powder, paniculate swallowwort, ginkgo leaf, honeysuckle, peppermint, Fructus meliae toosendan, dragon's blood, golden cypress, giant knotweed, lopseed, spina date seed, the root of Dahurain angelica, curcuma zedoary, stir-fry Cape jasmine, akebi, Chinese gall, rhizoma atractylodis, coix seed, reticulate millettia, cattail pollen, dandelion, levisticum, bush, caulis lonicerae, folium isatidis, bark of ash Deng composition.
Further, be made the Chinese medicine composition raw material composition and parts by weight be:Rhizome of davallia 5-12 parts, sweet wormwood 12-17 parts, root of Chinese trichosanthes 4-6 parts, paniculate swallowwort 8-12 parts, ginkgo leaf 3-4 parts, honeysuckle 12-15 parts, peppermint 5-9 parts, Fructus meliae toosendan 7- 12 parts, dragon's blood 4-9 parts, golden cypress 15-20 parts, giant knotweed 3-4 parts, lopseed 5-8 parts, spina date seed 12-15 parts, root of Dahurain angelica 10-16 parts, cowherb Art 3-8 parts, stir-baked FRUCTUS GARDENIAE 10-15 parts, akebi 8-12 parts, Chinese gall 2-5 parts, rhizoma atractylodis 3-7 parts, coix seed 11-14 parts, reticulate millettia 9- 15 parts, cattail pollen 3-6 parts, dandelion 8-13 parts, levisticum 3-5 parts, bush 1-3 parts, caulis lonicerae 5-10 parts, folium isatidis 5-10 parts, the Qin Macrophylla 13-16 parts.
Further, be made the Chinese medicine composition raw material composition and parts by weight be:12 parts of the rhizome of davallia, sweet wormwood 12 Part, 6 parts of root of Chinese trichosanthes, 8 parts of paniculate swallowwort, 3 parts of ginkgo leaf, 15 parts of honeysuckle, 5 parts of peppermint, 10 parts of Fructus meliae toosendan, 9 parts of dragon's blood, golden cypress 15 Part, 3 parts of giant knotweed, 5 parts of lopseed, 12 parts of spina date seed, 16 parts of the root of Dahurain angelica, 3 parts of curcuma zedoary, 15 parts of stir-baked FRUCTUS GARDENIAE, 8 parts of akebi, Chinese gall 5 Part, 3 parts of rhizoma atractylodis, 14 parts of coix seed, 9 parts of reticulate millettia, 6 parts of cattail pollen, 8 parts of dandelion, 5 parts of levisticum, 1 part of bush, 10 parts of caulis lonicerae, 5 parts of folium isatidis, 16 parts of bark of ash.
Further, be made the Chinese medicine composition raw material composition and parts by weight be:5 parts of the rhizome of davallia, 17 parts of sweet wormwood, 4 parts of root of Chinese trichosanthes, 10 parts of paniculate swallowwort, 4 parts of ginkgo leaf, 13 parts of honeysuckle, 6 parts of peppermint, 12 parts of Fructus meliae toosendan, 4 parts of dragon's blood, golden cypress 20 Part, 4 parts of giant knotweed, 8 parts of lopseed, 15 parts of spina date seed, 10 parts of the root of Dahurain angelica, 8 parts of curcuma zedoary, AI10 parts, 12 parts of akebi, 2 parts of Chinese gall is grey 7 parts of art, 11 parts of coix seed, 15 parts of reticulate millettia, 3 parts of cattail pollen, 13 parts of dandelion, 3 parts of levisticum, 3 parts of bush, 5 parts of caulis lonicerae, smalt 10 parts of leaf, 13 parts of bark of ash.
Further, be made the Chinese medicine composition raw material composition and parts by weight be:6 parts of the rhizome of davallia, 13 parts of sweet wormwood, 5 parts of root of Chinese trichosanthes, 12 parts of paniculate swallowwort, 3 parts of ginkgo leaf, 12 parts of honeysuckle, 9 parts of peppermint, 7 parts of Fructus meliae toosendan, 5 parts of dragon's blood, 18 parts of golden cypress, 4 parts of giant knotweed, 7 parts of lopseed, 13 parts of spina date seed, 11 parts of the root of Dahurain angelica, 4 parts of curcuma zedoary, 11 parts of stir-baked FRUCTUS GARDENIAE, 9 parts of akebi, 4 parts of Chinese gall is grey 6 parts of art, 12 parts of coix seed, 13 parts of reticulate millettia, 4 parts of cattail pollen, 9 parts of dandelion, 4 parts of levisticum, 2 parts of bush, 6 parts of caulis lonicerae, smalt 6 parts of leaf, 14 parts of bark of ash.
The preparation method of the Chinese medicine composition comprises the following steps:
(1) each medicinal material of components by weight percent in any Chinese medicine composition is taken, is crushed by pulverizer after mixing, medicinal powder Fineness is 100 mesh, and the medicinal powder after meal carries out ultramicro grinding through superfine communication technique, medicinal powder average grain diameter is less than 100 μm;
(2) soaked 2.5 hours in micropowders in step (1) being added into 10 times of ethanol of amount, heating extraction 2 times, every time 1.5 hours, supernatant is taken, merge extract solution, 120 mesh are filtered, then through the ultrafiltration post ultrafiltration that the molecular weight that dams is 12000, ultrafiltration The medicinal extract of 1.20-1.25, stand for standby use when liquid relative density concentrated under reduced pressure is 80 DEG C;
(3) dregs of a decoction that ethanol in step (2) was extracted are put into 10 times of amount water, are then placed in extractor heating and boil 1.5-2 hours, filtering, filtrate was standby;Filter residue adds water, second heating, boils 45-60 minutes, filters, and filtrate is standby;
(4) after the filtrate that the medicinal extract for being concentrated to give step (2) is obtained with step (3) mixes, the 2-4 times of distillation measured is added Water is stirred, and heating is boiled 0.5 hour, stands 1 hour, and extraction filters to get filtrate, and is sealed up for safekeeping filtrate is filling, 122 DEG C -125 DEG C pressure sterilizing 20-30 minutes, obtain final product the traditional Chinese medicine liquid for swelling and pain relieving.
Chinese medicine composition for swelling and pain relieving provided by the present invention, it fully sends out with common Chinese herbal medicine as raw material Wave the property of medicine of each component:
The rhizome of davallia, nature and flavor:It is bitter, warm in nature, the effect of with filling liver kidney, strengthening the bones and muscles, promoting blood circulation and stopping pain, for treating the acid of waist and knee bone Bitterly, arthralgia pain due to rheumatism, foot and knee flaccidity, kidney deficiency let out long, the bruise sudden strain of a muscle, tinnitus, toothache, bone fracture, appendicitis, alopecia areata, corn and kidney Void is let out long.
Sweet wormwood, bitter, acrid, cold.Return liver, gallbladder channel.Indication:Clearing away summerheat, except steaming, preventing malaria.For summer-heat evil heating, the deficiency of Yin Heating, night fever abating at dawn, hectic fever due to yin labor heat, malaria fever and chills, jaundice with damp-heat pathogen.
Root of Chinese trichosanthes:Sweet, slight bitter, cold nature enters lung, stomach, with clearing heat and promoting fluid, effect of detumescence and apocenosis, for heat Sick polydipsia, lung-heat type cough, Heat Diabetes, sore swollen toxin etc. are demonstrate,proved, and root of Chinese trichosanthes has suppression to immune system and stimulates double action, right Cancer cell has efficient direct killing effect,《Collected statements on the herbal foundation》:Root of Chinese trichosanthes, it is hot and suffocating to move back the five internal organs, and such as internal heat is contained and dry tongue and mouth, lung Fire is contained and pharynx swelling larynx numbness, and spleen fire is contained and dispute tooth is swollen, and convulsive seizure due to phlegm-fire is contained and coughed not peaceful.If the side of body of irascibility is swollen walking note, the hectic fever due to yin of kidney fire Dysphoria with smothery sensation, or ulcer is not burst, and heat toxin does not dissipate, or five subcutaneous ulcer yellow skin and eyes, if and if small water drench it is puckery, be all burning hot pent-up institute Cause, only this agent energy relieving stagnation, drop convulsive seizure due to phlegm-fire, and it can be controlled.Its property is sweet cold again, kind to control thirsty, controls empty thirsty from tonic, from the medicine of a cold nature Control fiery thirsty, control strongly fragrant thirsty from gas medicine, polydipsia is controlled from blood medicine, be to control thirsty key medicine.
Paniculate swallowwort, cures mainly:Analgesia, cough-relieving, inducing diuresis for removing edema, promoting blood circulation and detoxication.Treat for stomachache, have a toothache, rheumatalgia pain, menstrual period abdomen Bitterly, chronic bronchitis, ascites, oedema, dysentery, enteritis, traumatic injury, eczema, nettle rash, venomous snake bite.1st, for rheumatism numbness Bitterly, the various pains such as pain in the back, traumatic injury pain, abdominal pain, toothache.Paniculate swallowwort has preferable wind-expelling pain-stopping to act on, widely For the various pains caused by rheumatism, cold solidifying, the stagnation of the circulation of vital energy, blood stasis.Postoperative pain and cancerous swelling pain are also used in recent years, there is certain Analgesic effect.Can single application, or with the card relevant medicine of compatibility.2nd, with skin diseases such as eczema, wheal, stubborn dermatitis.This product There is dispelling wind and arresting itching to act on.Can alone for oral administration or decoct soup washout, also can the eliminating dampness and heat such as compatibility kuh-seng, the fruit of summer cypress, the root bark of shaggy-fruited dittany medicine Thing.Additionally, this product can also antidote against snake bite, venomous snake bite is controlled.Can be same with Chinese lobelia with for oral administration or external application.
Ginkgo leaf:Indication:Relieving asthma, it is promoting blood circulation and removing blood stasis, analgesic, for deficiency syndrome of the lung cough and asthma, coronary heart diseases and angina pectoris, high fat of blood.
Honeysuckle, nature and flavor:It is sweet, cold in nature, with clearing heat and detoxicating, dispelling wind and heat from the body, dredge throat, relieve summer heat relieving restlessness the effect of, For treating the illnesss such as summer fever, rush down dysentery, influenza, sore furuncle poison, acute and chronic tonsillitis, periodontitis.
Peppermint:It is pungent, it is cool.Return lung, Liver Channel.Effect with cure mainly:Dispelling wind-heat, refresh oneself, promoting eruption.For anemopyretic cold, wind Temperature is from the beginning of headache, hot eyes, larynx numbness, mesh sore, rubella, measles, Breast bilges frowsty about.
Fructus meliae toosendan:Chinese medicine, is the ripening fruits of Meliaceae deciduous tree toosendanin, and cold in nature, bitter is the one of qi-activating drug Kind.There are easypro liver promoting qi circulation and relieving pain, the drug effect of expelling parasite.For chest side of body, abdominal distention, colic, abdominal pain due to enterositosis.But also be to make efficient Important source material without the free of contamination novel plant agricultural chemicals of residual hazard.Fructus meliae toosendan bitter cold is settled, and mainly enters Liver Channel, and catharsis liver is hot, OK Gas is relieved pain, and is controlled the obstruction of the circulation of vital energy and is had the card of heat outstanding preferably.
Dragon's blood:Promoting blood circulation to remove blood stasis for oral administration, analgesic therapy, external application hemostasia and promoting granulation, sore.Cure mainly:1. extravasated blood Amenorrhea, dysmenorrhoea, the postpartum stasis of blood Resistance.2. abdominal mass lump in the abdomen, chest and abdomen shouting pain.3. traumatic injury, extravasated blood swells and ache.4. traumatism and bleeding, unhealing ulcer.From Liliaceae sword-like leave Dragon tree or dracaena cambodiana Pierre resin.
Golden cypress:This product is the dry bark of rutaceae wampee Phellodendron chinense Schneid.. Bitter, cold in nature, energy heat-clearing and damp-drying drug, except lower Jiao is wet swollen.《Medication heart method》Record golden cypress:" control the unbearably painful person of sore." golden cypress contains A large amount of composition of alkaloids, there is the antibacterial action of wide spectrum, can block nerves section, Central nervous play the role of suppression.
Giant knotweed slight bitter, it is slightly cold.Return liver, courage, lung channel.With clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, scattered stasis pain, only Cough the function of resolving sputum.Cure mainly joint pain, jaundice with damp-heat pathogen, Amenorrhea, wei lump in the abdomen, coughing with a lot of sputum, scald, injury from falling down, carbuncle swells Sore.Pregnant woman uses with caution.
Lopseed:Alias:Impatientis, buttercup, spill that golden flower, water caltrop water caltrop be careless, small pink, nail is careless.Taste is pungent, hardship, it is warm in nature.Return Liver and kidney channel.It is euphorbia plant speranskia tuberculata or the celestial herb of Balsaminaceae plant phoenix.Germination spray -3- the acetonitriles of pile containing Yin, stem Containing Kaempferol-glycoside, Quercetin -3- glycosides, form line India element -3- glycoside, Cyanidin -5- glucose Glucoside, leaf is containing 1,2,4- trihydroxynaphthalene -4- glycosides and Kaempferol and Kaempferol-Arab's glucoside.With dispelling wind and eliminating dampness, relax Muscle is invigorated blood circulation, eliminating stasis to subdue swelling, the effect for mesh pain of detoxifying.For arthralgia pain due to rheumatism, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, lumbar strain is paralysed, Amenorrhoea, eczema of scrotum, sore furuncle poison.
Spina date seed:Base:It is the seed of rhamnaceae plant wild jujube.Chemical analysis:It is main to contain two kinds of triterpenoids:White birch fat Alcohol, betulic acid.Separately contain jujuboside, glucoside unit is jujubogenin, and the Ebelin Lactone obtained by hydrolysis is the second step of saponin Product.Also vitamin C containing volume.Pharmacological action:1. calm, syngignoscism, 2. analgesia, anticonvulsion, cooling effect, 3. to painstaking effort The influence of guard system, the 4. influence to burning.Nature and flavor:It is sweet, put down.Return through:Enter the heart, spleen, liver, gallbladder channel.Indication:Nourishing the liver, rather The heart, calms the nerves, arrest sweating.Restlessness of asrhenia type and insomnia is controlled, palpitate with fear palpitation, polydipsia, abnormal sweating.
The root of Dahurain angelica, warm in nature, taste is pungent micro-sweet, with dispelling wind and eliminating dampness;Logical stealing relieves pain;Effect of detumescence and apocenosis.Main cold headache;Eyebrow Rib ostalgia;Toothache;Nasal obstruction;Nasosinusitis;Wet victory chronic diarrhea;Women leukorrhea;Ulcer sores;Venomous snake bite.It is clinically used for cold headache, eyebrow Rib ostalgia, nasal obstruction, nasosinusitis, toothache, leukorrhea, sore swell and ache curative.Relieving exterior syndrome and dispelling cold is can also be used for, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness is stopped Band, detumescence and apocenosis.Control headache, pain in the supra-orbital bone, dentalgia, nasosinusitis, cold-dampness stomachache, intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, skin Skin is dry to itch, mange.
Curcuma zedoary:Nature and flavor:Acrid, bitter, warm;Return through:Return liver, the spleen channel.Function:Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong.For Dan lump in the abdomen ruffians Block, blood stasis closed, dyspepsia distending pain;Early cervical carcinoma.
Stir-baked FRUCTUS GARDENIAE, it is bitter, tremble with fear.The thoughts of returning home, lung, tri-jiao channel.Cure mainly purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.For the pyreticosis heart It is tired, jaundice urine is red, blood strangury and dry pain, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles;Control bruise pain outward.
Akebi bitter, cold nature, returns spleen, the heart, small intestine, kidney, bladder warp, with heat-clearing, diuresis, invigorate blood circulation, promote blood circulation, let out it is turbid, The effects such as toxin expelling, control the illness such as red red urine, stranguria with turbid discharge, oedema, irritable feverish sensation in chest, arthralgia pain due to rheumatism, alactation, amenorrhoea, dysmenorrhoea.
Chinese gall, it is sour, it is puckery, it is cold in nature.Return lung, large intestine, kidney channel.Effect:Astringe the lung, hidroschesis, puckery intestines, controlling nocturnal emission with astringent drugs, hemostasis, solution Poison.Cure mainly:Chronic cough of deficiency lung, spontaneous sweating, protracted dysentery chronic diarrhea, prolapse of the anus, seminal emission, gonorrhoea, various bleedings, too fat to move boil.
Rhizoma atractylodis have drying damp and strengthening spleen a, expelling wind and clearing away cold, effect of improving eyesight, for dampness taste, abdominal fullness and distention, cold-dampness leukorrhea, Damp-warm diseases and damp invasion of lower energizer, pin swelling and pain in knee, impotence are soft powerless.Dampness taste are controlled, and sees that abdominal fullness and distention, poor appetite, burnout are weary The thick disease such as turbid of power, white and greasy fur, often with the compatibility application such as the bark of official magnolia, dried orange peel.
Coix seed:Enter spleen, lung, kidney channel.Invigorating the spleen, tonifying lung, heat-clearing, dampness removing.Diarrhea is controlled, arthritis with fixed pain caused by dampness, muscle arteries and veins contraction is bent and stretched not Profit, oedema, tinea pedis, consumptive lung disease, lung carbuncle, acute appendicitis, stranguria with turbid discharge, leukorrhea.
Reticulate millettia:It is bitter, sweet, it is warm in nature.Return liver and kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, blood deficiency chlorosis, fiber crops Wood paralysis, arthralgia pain due to rheumatism.
Cattail pollen, nature and flavor:It is sweet, put down.Return through:Return liver, pericardium channel.Indication:Hemostasis, stagnation resolvation is treating stranguria.For spitting blood, nosebleed Blood, spitting of blood, uterine bleeding, traumatism and bleeding, closed dysmenorrhea, gastral cavity abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.
Dandelion:It is feverfew dandelion Taraxacum mongolicum Hand.-Mazz., alkali ground dandelion Taraxacum sinicum Kitag. or belong to several plants together dry herb.It is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia. For furuncle swelling toxin, acute mastitis, scrofula, hot eyes, pharyngalgia, lung carbuncle, acute appendicitis, jaundice with damp-heat pathogen, puckery pain of heat gonorrhea.
Levisticum:Taste is pungent, hardship, slightly warm in nature.Return liver, kidney, bladder warp.Indication expelling wind and eliminating dampness, eliminating cold to stop pain;Cure mainly chill Arthritis with fixed pain caused by dampness;Lumbocrural pain, few the moon volt wind headache, dentalgia of having a headache.Modern pharmacology proves, levisticum have good analgesia, it is calm and Antiinflammatory action.
Bush, it is sweet, salty, put down.The thoughts of returning home, liver, the spleen channel.Indication:Promoting circulation of blood dissolving stasis, swelling and pain relieving.For closed dysmenorrhea, produce Stasis blocking afterwards, chest and abdomen shouting pain, wound swells and ache.
Caulis lonicerae:It is sweet, it is cold in nature.Attach to the lung and stomach meridians.It is clearing heat and detoxicating, dispelling wind dredging collateral.For warm disease heating, toxic-heat and blood stasis, carbuncle Swollen sore, beriberoid pyretic arthralgia, redness and swelling of joints heat pain.
Folium isatidis:Bitter, it is cold in nature.Return liver, the heart, stomach, the spleen channel.It is clearing heat and detoxicating, blood cooling and ecchymoses removing.For pyreticosis hyperpyrexia polydipsia; Coma;Macula;Spit blood;Bleeding from five sense organs or subcutaneous tissue;Jaundice;Rush down dysentery;Erysipelas;Larynx numbness;Aphtha;Mumps.
Bark of ash, toil is put down.Enter liver, stomach, gallbladder channel.Indication:Dispelling wind and eliminating dampness, and blood relaxing muscles and tendons, reducing fever and causing diuresis.Control rheumatism Numbness pain, muscles and bones contraction, jaundice is had blood in stool, osteopyrexia and fever, children's infantile malnutrition due to digestive disturbances or intestinalparasites heat, difficult urination.
Medicinal material compatibility is suitable selected by Chinese medicine composition for swelling and pain relieving of the invention, mutually collaboration, rapid-action, curative effect Significantly, patient compliance is good, safe without toxic side effect;Its preparation method is simple and easy to apply, and active constituent content is high, is adapted to extensive Production.
Specific embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with embodiment to this hair Bright technical scheme is clearly and completely described.Obviously, described embodiment is a part of the invention, rather than complete The embodiment in portion.Based on described embodiments of the invention, those of ordinary skill in the art are before without creative work The every other embodiment for being obtained is put, the scope of protection of the invention is belonged to.
Embodiment 1:
A kind of Chinese medicine composition for swelling and pain relieving of the invention, takes following traditional Chinese medicine raw medicine:12 parts of the rhizome of davallia, sweet wormwood 12 parts, 6 parts of root of Chinese trichosanthes, 8 parts of paniculate swallowwort, 3 parts of ginkgo leaf, 15 parts of honeysuckle, 5 parts of peppermint, 10 parts of Fructus meliae toosendan, 9 parts of dragon's blood, golden cypress 15 parts, 3 parts of giant knotweed, 5 parts of lopseed, 12 parts of spina date seed, 16 parts of the root of Dahurain angelica, 3 parts of curcuma zedoary, 15 parts of stir-baked FRUCTUS GARDENIAE, 8 parts of akebi, Chinese gall 5 Part, 3 parts of rhizoma atractylodis, 14 parts of coix seed, 9 parts of reticulate millettia, 6 parts of cattail pollen, 8 parts of dandelion, 5 parts of levisticum, 1 part of bush, 10 parts of caulis lonicerae, 5 parts of folium isatidis, 16 parts of bark of ash.
Wherein, the preparation method of the Chinese medicine composition is:
(1) each medicinal material of components by weight percent in any Chinese medicine composition is taken, is crushed by pulverizer after mixing, medicinal powder Fineness is 100 mesh, and the medicinal powder after meal carries out ultramicro grinding through superfine communication technique, medicinal powder average grain diameter is less than 100 μm;
(2) soaked 2.5 hours in micropowders in step (1) being added into 10 times of ethanol of amount, heating extraction 2 times, every time 1.5 hours, supernatant is taken, merge extract solution, 120 mesh are filtered, then through the ultrafiltration post ultrafiltration that the molecular weight that dams is 12000, ultrafiltration The medicinal extract of 1.20-1.25, stand for standby use when liquid relative density concentrated under reduced pressure is 80 DEG C;
(3) dregs of a decoction that ethanol in step (2) was extracted are put into 10 times of amount water, are then placed in extractor heating and boil 1.5-2 hours, filtering, filtrate was standby;Filter residue adds water, second heating, boils 45-60 minutes, filters, and filtrate is standby;
(4) after the filtrate that the medicinal extract for being concentrated to give step (2) is obtained with step (3) mixes, the 2-4 times of distillation measured is added Water is stirred, and heating is boiled 0.5 hour, stands 1 hour, and extraction filters to get filtrate, and is sealed up for safekeeping filtrate is filling, 122 DEG C -125 DEG C pressure sterilizing 20-30 minutes, obtain final product the traditional Chinese medicine liquid for swelling and pain relieving.
Embodiment 2:
A kind of Chinese medicine composition for swelling and pain relieving of the invention, takes following traditional Chinese medicine raw medicine:5 parts of the rhizome of davallia, sweet wormwood 17 parts, 4 parts of root of Chinese trichosanthes, 10 parts of paniculate swallowwort, 4 parts of ginkgo leaf, 13 parts of honeysuckle, 6 parts of peppermint, 12 parts of Fructus meliae toosendan, 4 parts of dragon's blood is yellow 20 parts of cypress, 4 parts of giant knotweed, 8 parts of lopseed, 15 parts of spina date seed, 10 parts of the root of Dahurain angelica, 8 parts of curcuma zedoary, AI10 parts, 12 parts of akebi, Chinese gall 2 Part, 7 parts of rhizoma atractylodis, 11 parts of coix seed, 15 parts of reticulate millettia, 3 parts of cattail pollen, 13 parts of dandelion, 3 parts of levisticum, 3 parts of bush, caulis lonicerae 5 Part, 10 parts of folium isatidis, 13 parts of bark of ash.
Preparation method is with embodiment 1.
Embodiment 3:
A kind of Chinese medicine composition for swelling and pain relieving of the invention, takes following traditional Chinese medicine raw medicine:6 parts of the rhizome of davallia, sweet wormwood 13 parts, 5 parts of root of Chinese trichosanthes, 12 parts of paniculate swallowwort, 3 parts of ginkgo leaf, 12 parts of honeysuckle, 9 parts of peppermint, 7 parts of Fructus meliae toosendan, 5 parts of dragon's blood, golden cypress 18 parts, 4 parts of giant knotweed, 7 parts of lopseed, 13 parts of spina date seed, 11 parts of the root of Dahurain angelica, 4 parts of curcuma zedoary, 11 parts of stir-baked FRUCTUS GARDENIAE, 9 parts of akebi, Chinese gall 4 Part, 6 parts of rhizoma atractylodis, 12 parts of coix seed, 13 parts of reticulate millettia, 4 parts of cattail pollen, 9 parts of dandelion, 4 parts of levisticum, 2 parts of bush, 6 parts of caulis lonicerae, 6 parts of folium isatidis, 14 parts of bark of ash.
Preparation method is with embodiment 1.
Acute toxicity test:
Test material:Kunming mouse 60, body weight 22-25g.Medicine:Liquid obtained in the embodiment of the present invention 2, contains 0.037mg/ml。
Method:LD50 is calculated:Using improvement karber's method, mouse is randomly divided into 4 groups, every group 15, liquid agent is added into steaming Distilled water dissolves, and is made into Cmax, is administered by the maximum allowable capacity of mouse, and institute is followed successively by 19.3,14.5 to dosage by crude drug amount, 12.4,9.3,7.1 (g.kg-1), after animal fasting (can't help water) 24 hours, are administered (interval half an hour) at twice in one day, Each 0.6ml, observes animal dead situation.
Result of the test:LD50 calculating in when mouse is given with maximum acceptable concentration and maximum allowable capacity (18.6g/ Kg.d), dead mouse is had no, that is, does not measure LD50, only seek maximum tolerated dose, to observation post administration 14 days, none was dead for mouse Die, main organs no abnormality seen also has no other obvious exceptions, puts to death and cut open inspection some animals within the 14th day, visually observes main Internal organs no abnormality seen.I.e. from 300 times of doses equivalent to clinical dosage, and have no adverse reaction, show acute toxicity pole It is small, MTD > 18.6g/Kg.d.
Six months long term toxicity tests:Weighed weekly once during administration, appetite is claimed daily, without dead or dying dynamic Thing, as a result mouse hair color is bright and clean, and behavioral activity, glandular secretion, breathing, fecal character are normal.Pathologic finding is pointed out, to various Internal organs are without obvious drug-induced pathological change.
Clinical reasoning:
In order to verify the effect of Chinese medicine composition of the present invention, in May, -2016 in October, 2014, urgency is randomly selected at outpatient service Property soft tissue injury patient 512, wherein man 267, female 245, the age is minimum 15 years old, and the oldest 66 years old, upper limbs was damaged 245, chest the small of the back damages 197, lower extremity injury 39, above damage person 31 at two.Treatment group 260 is randomly divided into, Control group 252.Two groups of courses of disease of case, degrees of symptoms are basically identical, without significant difference, with comparativity.
Selection gist:A has trauma history, and the course of disease is within 1 week.B is without drug allergy history.C damage after it is not used its His promoting blood flow and remove blood stasis drug.D is for x ray examinations have no fracture and dislocate.
Treatment method:
Treatment group:The traditional Chinese medicine liquid of the embodiment of the present invention 1 carries out scouring nursing to affected part, daily 4-6 times.
Control group:Using musk tiger bone plaster, manufacturer:Yellowstone Health Materials Medicine Industry Co., Ltd, soaks containing Moschus, medicinal material Cream, menthol, tiger bone, gaultherolin, leopard bone, borneol, chondroitin sulfate cream, the musk tiger bone plaster of bagodryl hydrochloride composition.
Two groups equal ten days is a course for the treatment of, and 2 courses for the treatment of are treated altogether.
Index 0 point 1 point 2 points 3 points
Pain It is painless Pain is light Substantially Acutely
Tenderness Without tenderness Slight pain That is the pain of pressure Tenderness
Swelling Without swelling Dermatoglyph is shallow clear Dermatoglyph is obscured Disappearance has fluctuation
Dysfunction Activity is freely Slightly Moderate Severe
Criterion of therapeutical effect:
Recovery from illness:It is 0 point after treatment;
It is effective:Clinical observation total score fall is more than 70% after treatment;
Effectively:Clinical observation total score declines more than 30%. less than 70% after treatment;
It is invalid:Clinical observation total score fall is less than 30% after treatment.
Clinical observation total score fall=[total score before (total score after total score-treatment before treatment)/treatment] * 100%.
Efficacy result:
1 two groups of patient clinicals comparitive study (example %) of table
Group Case load Cure It is effective Effectively It is invalid Total effective rate
Treatment group 260 157 (60.4%) 62 (23.8%) 39 (15%) 2 (0.7%) 258 (99.3%)
Control group 252 64 (25.4%) 88 (34.9%) 48 (19%) 52 (20.6%) 200 (79.4%)
Wherein, total effective rate=cure rate+obvious effective rate+effective percentage.Two groups do not occur adverse reaction.
Discuss:
Acute soft tissue injury is a kind of common clinical, in training, match and daily life, often goes out current situation Soft tissue different degrees of lancinating in portion's is damaged, and " injury of the tissues " category is belonged in tcm field, more due to caused by energy stagnation and blood stasis, is controlled Treat with vital energy regualting and blood circulation-promoting, the method for swelling and pain relieving.
Conclusion
The result of this test example shows:The Chinese medicine class anti-inflammation analgesic of middle offer compared to existing technology, what the present invention was provided Healing time is short, anti-inflammatory effects are good, drug effect is notable when acute soft tissue injury is treated for Chinese medicine composition.
Finally it should be noted that:The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations;Although The present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those within the art that:It still may be used Modified with to the technical scheme described in foregoing embodiments, or equivalent is carried out to which part technical characteristic; And these modifications or replacement, do not make the scope of the essence disengaging various embodiments of the present invention technical scheme of appropriate technical solution.

Claims (6)

1. a kind of Chinese medicine composition for swelling and pain relieving, it is characterised in that:The bulk drug of the Chinese medicine composition by the rhizome of davallia, It is sweet wormwood, root of Chinese trichosanthes, paniculate swallowwort, ginkgo leaf, honeysuckle, peppermint, Fructus meliae toosendan, dragon's blood, golden cypress, giant knotweed, lopseed, spina date seed, white It is the root of Dahurian angelica, curcuma zedoary, stir-baked FRUCTUS GARDENIAE, akebi, Chinese gall, rhizoma atractylodis, coix seed, reticulate millettia, cattail pollen, dandelion, levisticum, bush, caulis lonicerae, big Leafiness, bark of ash etc. are constituted.
2. the Chinese medicine composition for swelling and pain relieving according to claim 1, it is characterised in that:It is made the Chinese traditional medicine composition The raw material of thing is constituted and parts by weight are:Rhizome of davallia 5-12 parts, sweet wormwood 12-17 parts, root of Chinese trichosanthes 4-6 parts, paniculate swallowwort 8-12 parts, silver 3-4 parts of apricot leaf, honeysuckle 12-15 parts, peppermint 5-9 parts, Fructus meliae toosendan 7-12 parts, dragon's blood 4-9 parts, golden cypress 15-20 parts, giant knotweed 3-4 Part, lopseed 5-8 parts, spina date seed 12-15 parts, root of Dahurain angelica 10-16 parts, curcuma zedoary 3-8 parts, stir-baked FRUCTUS GARDENIAE 10-15 parts, akebi 8-12 parts, Chinese gall 2-5 parts, rhizoma atractylodis 3-7 parts, coix seed 11-14 parts, reticulate millettia 9-15 parts, cattail pollen 3-6 parts, dandelion 8-13 parts, levisticum 3-5 parts, bush 1-3 parts, caulis lonicerae 5-10 parts, folium isatidis 5-10 parts, bark of ash 13-16 parts.
3. the Chinese medicine composition for swelling and pain relieving according to claim 2, it is characterised in that:It is made the Chinese traditional medicine composition The raw material of thing is constituted and parts by weight are:12 parts of the rhizome of davallia, 12 parts of sweet wormwood, 6 parts of root of Chinese trichosanthes, 8 parts of paniculate swallowwort, 3 parts of ginkgo leaf, gold 15 parts of honeysuckle flower, 5 parts of peppermint, 10 parts of Fructus meliae toosendan, 9 parts of dragon's blood, 15 parts of golden cypress, 3 parts of giant knotweed, 5 parts of lopseed, 12 parts of spina date seed, in vain 16 parts of the root of Dahurian angelica, 3 parts of curcuma zedoary, 15 parts of stir-baked FRUCTUS GARDENIAE, 8 parts of akebi, 5 parts of Chinese gall, 3 parts of rhizoma atractylodis, 14 parts of coix seed, 9 parts of reticulate millettia, cattail pollen 6 parts, 8 parts of dandelion, 5 parts of levisticum, 1 part of bush, 10 parts of caulis lonicerae, 5 parts of folium isatidis, 16 parts of bark of ash.
4. the Chinese medicine composition for swelling and pain relieving according to claim 2, it is characterised in that:It is made the Chinese traditional medicine composition The raw material of thing is constituted and parts by weight are:5 parts of the rhizome of davallia, 17 parts of sweet wormwood, 4 parts of root of Chinese trichosanthes, 10 parts of paniculate swallowwort, 4 parts of ginkgo leaf, gold 13 parts of honeysuckle flower, 6 parts of peppermint, 12 parts of Fructus meliae toosendan, 4 parts of dragon's blood, 20 parts of golden cypress, 4 parts of giant knotweed, 8 parts of lopseed, 15 parts of spina date seed, in vain 10 parts of the root of Dahurian angelica, 8 parts of curcuma zedoary, AI10 parts, 12 parts of akebi, 2 parts of Chinese gall, 7 parts of rhizoma atractylodis, 11 parts of coix seed, 15 parts of reticulate millettia, cattail pollen 3 Part, 13 parts of dandelion, 3 parts of levisticum, 3 parts of bush, 5 parts of caulis lonicerae, 10 parts of folium isatidis, 13 parts of bark of ash.
5. the Chinese medicine composition for swelling and pain relieving according to claim 2, it is characterised in that:It is made the Chinese traditional medicine composition The raw material of thing is constituted and parts by weight are:6 parts of the rhizome of davallia, 13 parts of sweet wormwood, 5 parts of root of Chinese trichosanthes, 12 parts of paniculate swallowwort, 3 parts of ginkgo leaf, gold 12 parts of honeysuckle flower, 9 parts of peppermint, 7 parts of Fructus meliae toosendan, 5 parts of dragon's blood, 18 parts of golden cypress, 4 parts of giant knotweed, 7 parts of lopseed, 13 parts of spina date seed, the root of Dahurain angelica 11 parts, 4 parts of curcuma zedoary, 11 parts of stir-baked FRUCTUS GARDENIAE, 9 parts of akebi, 4 parts of Chinese gall, 6 parts of rhizoma atractylodis, 12 parts of coix seed, 13 parts of reticulate millettia, cattail pollen 4 Part, 9 parts of dandelion, 4 parts of levisticum, 2 parts of bush, 6 parts of caulis lonicerae, 6 parts of folium isatidis, 14 parts of bark of ash.
6. according to the preparation method of any described Chinese medicine compositions for swelling and pain relieving of claim 1-5, it is characterised in that Comprise the following steps:
(1) each medicinal material of components by weight percent in any Chinese medicine composition is taken, is crushed by pulverizer after mixing, medicinal powder fineness It is 100 mesh, the medicinal powder after meal carries out ultramicro grinding through superfine communication technique, medicinal powder average grain diameter is less than 100 μm;
(2) soaked 2.5 hours in micropowders in step (1) being added into 10 times of ethanol of amount, heating extraction 2 times, 1.5 is small every time When, supernatant is taken, merge extract solution, the filtration of 120 mesh, then through the ultrafiltration post ultrafiltration that the molecular weight that dams is 12000, ultrafiltrate depressurizes The medicinal extract of 1.20-1.25, stand for standby use when concentration relative density is 80 DEG C;
(3) dregs of a decoction that ethanol in step (2) was extracted are put into 10 times of amount water, are then placed in extractor heating and boil 1.5-2 Hour, filtering, filtrate is standby;Filter residue adds water, second heating, boils 45-60 minutes, filters, and filtrate is standby;
(4) after the filtrate that the medicinal extract for being concentrated to give step (2) is obtained with step (3) mixes, the 2-4 times of distilled water measured is added to stir Mix uniform, heating is boiled 0.5 hour, stand 1 hour, extraction filters to get filtrate, seal up for safekeeping filtrate is filling, 122 DEG C of -125 DEG C of heat Pressure sterilizing 20-30 minutes, obtains final product the traditional Chinese medicine liquid for swelling and pain relieving.
CN201710083093.2A 2017-02-16 2017-02-16 A kind of Chinese medicine composition for swelling and pain relieving and preparation method thereof Pending CN106729443A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109010571A (en) * 2018-09-10 2018-12-18 广州市焕思仪器科技有限公司 A kind of antibacterial Chinese medicine composition and preparation method thereof

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CN103784550A (en) * 2014-02-26 2014-05-14 焦文鹏 Traditional Chinese medicinal composition for relieving swelling and pain and preparation thereof
CN105106634A (en) * 2015-09-07 2015-12-02 江淑芬 Traditional Chinese medicine preparation for treating acute appendicitis and application thereof
CN105233188A (en) * 2015-11-24 2016-01-13 江崇礼 Traditional Chinese medicine composition for treating liver cancer and application of traditional Chinese medicine composition
CN105343660A (en) * 2015-11-06 2016-02-24 青岛市市立医院 Traditional Chinese medicinal preparation for treating peripheral vertigo and preparation method of traditional Chinese medicinal preparation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103784550A (en) * 2014-02-26 2014-05-14 焦文鹏 Traditional Chinese medicinal composition for relieving swelling and pain and preparation thereof
CN105106634A (en) * 2015-09-07 2015-12-02 江淑芬 Traditional Chinese medicine preparation for treating acute appendicitis and application thereof
CN105343660A (en) * 2015-11-06 2016-02-24 青岛市市立医院 Traditional Chinese medicinal preparation for treating peripheral vertigo and preparation method of traditional Chinese medicinal preparation
CN105233188A (en) * 2015-11-24 2016-01-13 江崇礼 Traditional Chinese medicine composition for treating liver cancer and application of traditional Chinese medicine composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109010571A (en) * 2018-09-10 2018-12-18 广州市焕思仪器科技有限公司 A kind of antibacterial Chinese medicine composition and preparation method thereof

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Application publication date: 20170531