CN105233188A - Traditional Chinese medicine composition for treating liver cancer and application of traditional Chinese medicine composition - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating the liver cancer and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from pseudo-ginseng, gastrodia elata, nightshade, curcuma zedoary, fiveleaf akebia fruits, dandelions, fingered citrons, selfheal, polygonum cuspidatum, endothelium corneum gigeriae galli, glossy privet fruits, ampelopsis japonica, gynostemma pentaphylla, acanthopanax, pinellia ternate, smoked plums, golden cypress, bamboo fungi, lithospermum, sedum sarmentosum, salvia chinensis, lalang grass rhizome, semen plantaginis, moleplant seeds, ocimum gratissimum, cimicifugae foetidae, polygonum multiflorum, human placentas, caulis spatholobi, paris polyphylla, leeches, corn stigmas and liquorice. The selected medicinal materials of the traditional Chinese medicine composition are appropriate in compatibility, the traditional Chinese medicine composition conforms to traditional Chinese medicine and modern medicine theories, has the effects of discharging the liver and regulating qi, reducing phlegm and resolving masses, reinforcing qi and nourishing blood, activating blood to promote menstruation, and dispersing blood stasis and achieving diuresis, and is remarkable in curative effect, free of poor, toxic and side effects, convenient to prepare, low in cost and suitable for clinical application and popularization.

Description

A kind of Chinese medicine composition being used for the treatment of hepatocarcinoma and uses thereof

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition being used for the treatment of hepatocarcinoma and uses thereof.

Background technology

Hepatocarcinoma (livercancer) is the third-largest common cancer that mortality rate is only second to gastric cancer, esophageal carcinoma, and initial symptoms is also not obvious, late period main manifestations be liver pain, weak, become thin, the symptom such as jaundice, ascites.The pathomechanism of hepatocarcinoma comprises in the invasion of six climate exopathogens evil poison, exogenous pathogen, evil solidifying poison knot, with the passing of time become long-pending, and internal organs Qi and blood deficiency, stagnation of dampness due to deficiency of the spleen, qi depression to blood stasis, outside the Pass illustrating that hepatocarcinoma is removed and to be had with hepatitis and extraneous poisonous factor, also declines relevant with autoimmunity.

The cause of disease of hepatocarcinoma, doctor trained in Western medicine thinks mainly relevant with chronic hepatic diseases, aflatoxin, parasite, excessive drinking, inherited genetic factors.In China, the factor maximum with onset of liver cancer rate relation is hepatitis B virus, particularly HBsAg positive.Therefore, HBsAg positive and patients with chronic liver are listed in the high-risk group of hepatocarcinoma.Have research to think, HBsAg has directly carcinogenic possibility, and is not necessarily by this interstage of chronic hepatopathy.The traditional Chinese medical science thinks that primary disease loses primarily of internal organs asthenia of qi and blood, insufficiency of the spleen wet poly-, the expectorant blood coagulation stasis of blood; The evil poison invasion of six climate exopathogens, evil solidifying poison knot, internal injury caused by excess of seven emotions, depressed emotion etc., can make gas, blood, wet, heat, the stasis of blood, poison tie mutually and form hepatocarcinoma.Primary disease disease located in liver, closely related with spleen, gallbladder, stomach, main pathogenesis is weakened body resistance in interior, and evil poison pents up.

By dialectical treatmert, hepatocarcinoma is divided into following five types: 1, liver qi stagnation type disease sees pain in chest and hypochondrium, does not uncomfortable in chestly relax, angry postemphasis, hepatomegaly, anorexia, thin white fur of tongue, stringy pulse.Controlling should depressed liver-energy dispersing and QI regulating.2, stagnation of dampness due to deficiency of the spleen type disease sees that breast coerces vexed pain, the lower mass in the abdomen of the side of body, and inappetence, or nauseating belch are weak, or loose stool, and there is indentation on light red tongue limit, white and thin fur, deep-slow pulse.Controlling should invigorating the spleen to clear away damp pathogen.3, qi stagnation and blood stasis type disease sees distending pain in the chest and hypochondrium, and sore spot is fixing not to be moved, and night, more so the lower mass in the abdomen of the side of body, belch or singultus, swollen anorexia, dry stool oliguria, purplish tongue secretly had ecchymosis, white and thin fur or greasy, thready and hesitant pulse.Control suitable blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.4, liver gallbladder damp-heat type disease sees upper abdominal lump, distension and fullness in the abdomen, order skin xanthochromia, and enlarged abdomen is as drum, and vexed bitter taste, anorexia of feeling sick, constipation is drowned yellow, and purplish tongue is dark, thick, yellow and greasy fur, slippery and rapid pulse.Control suitable eliminating damp-heat, change silt eliminating stagnation.5, liver-kidney yin deficiency disease sees distending pain over the hypochondrium, becomes thin weak, low grade fever night sweat, dysphoria with feverish sensation in the chest palms and soles, and skin is dark and gloomy, dry stool oliguria, the few tongue of red tongue, thready and rapid pulse.Control suitable nourishing YIN and clearing away heat, right supporting anticancer.Above typing is typical pattern of syndrome, but often simulataneous insufficiency and excessive clinically, clinically controls when distinguish with card.Generally early stage based on the stagnation of QI, mid-term based on blood stasis, cold-damp, late period many hepatic and renal YIN deficiency.

Hepatocarcinoma can betide any age, but is many with 31 ~ 50 years old, and the ratio of men and women is about 8: 1.More than 90% belong to when making a definite diagnosis in, late period, surgical engine can many miss, so adopt modern comprehensive treatment to be often subject to a definite limitation because of Radiotherapy chemotherapy and immunization therapy; And Radiotherapy chemotherapy is very big to the treatment toxicity of primary disease, indication then reduces, and curative effect is also poor; Though interventional therapy has certain curative effect, need quite high condition and equipment, spend also larger.

Operation, radiotherapy and chemotherapy is depended at present in Hepatoma therapy, systemic chemotherapy is to liver cancer patient DeGrain, and generally, the metabolism in liver of most of cancer therapy drug, short time is difficult to take effect, and the untoward reaction that chemotherapy is brought simultaneously also have impact on the life quality of patient to a certain extent.The current mainly topical therapeutic for the treatment of of hepatocarcinoma, comprises TACE, PEI, radio-frequency (RF) ablation, radiotherapy and operative treatment etc.Various method has its pluses and minuses and indication, but all has side effect in various degree.TACE postoperative patient often merges the complication such as heating, pain, vomiting and liver dysfunction, not only affects patients ' life quality, and not congruent being easy to of postoperative borderline tumor covering is recurred.Palliative external exposure radiotherapy is a kind of effective topical therapeutic means, but the complication such as the visceral organ injury of normal merging radioactivity, bone marrow depression.TACE, radio-frequency (RF) ablation and fractionated radiation treatments etc. are implemented to damage liver function repeatedly, increase the weight of liver cirrhosis further.Rely on ethanol diffusion in PEI operation process, and liver cancer patient merges liver cirrhosis, the quality of liver is uneven, affects diffusion and the direction of ethanol.In addition, said method is while killing cancerous cell, and human normal cell comes to harm too, and has the Western medicine of antitumaous effect, and side effect is large, and curative effect is not obvious, and somewhat expensive.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition being used for the treatment of hepatocarcinoma and uses thereof, this Chinese medicine composition is prepared easy, evident in efficacy, without bad and toxic and side effects, and wide adaptability.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Be used for the treatment of a Chinese medicine composition for hepatocarcinoma, the crude drug of described Chinese medicine composition is made up of Radix Notoginseng, Rhizoma Gastrodiae, Herba Solani Nigri, Rhizoma Curcumae, Fructus Akebiae, Herba Taraxaci, Fructus Citri Sarcodactylis, Spica Prunellae, Rhizoma Polygoni Cuspidati, Endothelium Corneum Gigeriae Galli, Fructus Ligustri Lucidi, Radix Ampelopsis, Herb Gynostemmae Pentaphylli, Radix Et Caulis Acanthopanacis Senticosi, the Rhizoma Pinelliae, Fructus Mume, Cortex Phellodendri, Caulis Bambusae In Taeniam, Radix Arnebiae (Radix Lithospermi), Herba Sedi, Herba Salviae Chinensis, Rhizoma Imperatae, Semen Plantaginis, Semen Euphorbiae, Ocimum Basilicum, Rhizoma Cimicifugae, Radix Polygoni Multiflori, Placenta Hominis, Caulis Spatholobi, Rhizoma Paridis, Hirudo, Stigma Maydis, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 3-5 part, Rhizoma Gastrodiae 1-3 part, Herba Solani Nigri 12-17 part, Rhizoma Curcumae 7-12 part, Fructus Akebiae 4-9 part, Herba Taraxaci 15-20 part, Fructus Citri Sarcodactylis 10-15 part, Spica Prunellae 8-12 part, Rhizoma Polygoni Cuspidati 2-5 part, Endothelium Corneum Gigeriae Galli 3-7 part, Fructus Ligustri Lucidi 11-14 part, Radix Ampelopsis 9-15 part, Herb Gynostemmae Pentaphylli 3-6 part, Radix Et Caulis Acanthopanacis Senticosi 8-13 part, Rhizoma Pinelliae 3-5 part, Fructus Mume 1-3 part, Cortex Phellodendri 3-6 part, Caulis Bambusae In Taeniam 8-13 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Herba Sedi 11-15 part, Herba Salviae Chinensis 5-10 part, Rhizoma Imperatae 2-5 part, Semen Plantaginis 4-9 part, Semen Euphorbiae 12-20 part, Ocimum Basilicum 10-16 part, Rhizoma Cimicifugae 3-8 part, Radix Polygoni Multiflori 5-12 part, Placenta Hominis 5-10 part, Caulis Spatholobi 5-10 part, Rhizoma Paridis 13-16 part, Hirudo 3-10 part, Stigma Maydis 8-13 part, Radix Glycyrrhizae 5-10 part.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 5 parts, 1 part, Rhizoma Gastrodiae, Herba Solani Nigri 12 parts, Rhizoma Curcumae 10 parts, Fructus Akebiae 9 parts, Herba Taraxaci 15 parts, Fructus Citri Sarcodactylis 15 parts, Spica Prunellae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Ligustri Lucidi 14 parts, Radix Ampelopsis 9 parts, Herb Gynostemmae Pentaphylli 6 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 1 part, Cortex Phellodendri 6 parts, Caulis Bambusae In Taeniam 8 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Herba Sedi 15 parts, Herba Salviae Chinensis 5 parts, Rhizoma Imperatae 3 parts, Semen Plantaginis 5 parts, Semen Euphorbiae 12 parts, Ocimum Basilicum 16 parts, Rhizoma Cimicifugae 3 parts, Radix Polygoni Multiflori 12 parts, Placenta Hominis 10 parts, Caulis Spatholobi 5 parts, Rhizoma Paridis 16 parts, Hirudo 10 parts, Stigma Maydis 8 parts, 10 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 3 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 17 parts, Rhizoma Curcumae 12 parts, Fructus Akebiae 4 parts, Herba Taraxaci 20 parts, Fructus Citri Sarcodactylis 10 parts, Spica Prunellae 12 parts, Rhizoma Polygoni Cuspidati 2 parts, Endothelium Corneum Gigeriae Galli 7 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 15 parts, Herb Gynostemmae Pentaphylli 3 parts, Radix Et Caulis Acanthopanacis Senticosi 13 parts, the Rhizoma Pinelliae 3 parts, Fructus Mume 3 parts, Cortex Phellodendri 4 parts, Caulis Bambusae In Taeniam 10 parts, Radix Arnebiae (Radix Lithospermi) 4 parts, Herba Sedi 13 parts, Herba Salviae Chinensis 6 parts, Rhizoma Imperatae 4 parts, Semen Plantaginis 8 parts, Semen Euphorbiae 20 parts, Ocimum Basilicum 10 parts, Rhizoma Cimicifugae 8 parts, Radix Polygoni Multiflori 5 parts, Placenta Hominis 5 parts, Caulis Spatholobi 10 parts, Rhizoma Paridis 13 parts, Hirudo 3 parts, Stigma Maydis 13 parts, 5 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 4 parts, 2 parts, Rhizoma Gastrodiae, Herba Solani Nigri 13 parts, Rhizoma Curcumae 7 parts, Fructus Akebiae 5 parts, Herba Taraxaci 18 parts, Fructus Citri Sarcodactylis 11 parts, Spica Prunellae 9 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 6 parts, Fructus Ligustri Lucidi 12 parts, Radix Ampelopsis 13 parts, Herb Gynostemmae Pentaphylli 4 parts, Radix Et Caulis Acanthopanacis Senticosi 9 parts, the Rhizoma Pinelliae 4 parts, Fructus Mume 2 parts, Cortex Phellodendri 5 parts, Caulis Bambusae In Taeniam 12 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Herba Sedi 12 parts, Herba Salviae Chinensis 9 parts, Rhizoma Imperatae 4 parts, Semen Plantaginis 7 parts, Semen Euphorbiae 13 parts, Ocimum Basilicum 11 parts, Rhizoma Cimicifugae 4 parts, Radix Polygoni Multiflori 6 parts, Placenta Hominis 6 parts, Caulis Spatholobi 6 parts, Rhizoma Paridis 14 parts, Hirudo 5 parts, Stigma Maydis 10 parts, 6 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 3 parts, 1 part, Rhizoma Gastrodiae, Herba Solani Nigri 16 parts, Rhizoma Curcumae 8 parts, Fructus Akebiae 8 parts, Herba Taraxaci 16 parts, Fructus Citri Sarcodactylis 14 parts, Spica Prunellae 11 parts, Rhizoma Polygoni Cuspidati 3 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Ligustri Lucidi 13 parts, Radix Ampelopsis 14 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Rhizoma Pinelliae 3 parts, Fructus Mume 1 part, Cortex Phellodendri 4 parts, Caulis Bambusae In Taeniam 11 parts, Radix Arnebiae (Radix Lithospermi) 4 parts, Herba Sedi 14 parts, Herba Salviae Chinensis 8 parts, Rhizoma Imperatae 3 parts, Semen Plantaginis 6 parts, Semen Euphorbiae 17 parts, Ocimum Basilicum 15 parts, Rhizoma Cimicifugae 7 parts, Radix Polygoni Multiflori 11 parts, Placenta Hominis 10 parts, Caulis Spatholobi 9 parts, Rhizoma Paridis 13 parts, Hirudo 7 parts, Stigma Maydis 11 parts, 10 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 5 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 15 parts, Rhizoma Curcumae 9 parts, Fructus Akebiae 7 parts, Herba Taraxaci 19 parts, Fructus Citri Sarcodactylis 13 parts, Spica Prunellae 10 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 11 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 3 parts, Cortex Phellodendri 6 parts, Caulis Bambusae In Taeniam 9 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Herba Sedi 12 parts, Herba Salviae Chinensis 7 parts, Rhizoma Imperatae 5 parts, Semen Plantaginis 9 parts, Semen Euphorbiae 15 parts, Ocimum Basilicum 12 parts, Rhizoma Cimicifugae 5 parts, Radix Polygoni Multiflori 9 parts, Placenta Hominis 8 parts, Caulis Spatholobi 8 parts, Rhizoma Paridis 14 parts, Hirudo 9 parts, Stigma Maydis 12 parts, 8 parts, Radix Glycyrrhizae.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 5 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 14 parts, Rhizoma Curcumae 9 parts, Fructus Akebiae 6 parts, Herba Taraxaci 17 parts, Fructus Citri Sarcodactylis 13 parts, Spica Prunellae 10 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 11 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 3 parts, Cortex Phellodendri 3 parts, Caulis Bambusae In Taeniam 8 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Herba Sedi 15 parts, Herba Salviae Chinensis 7 parts, Rhizoma Imperatae 2 parts, Semen Plantaginis 4 parts, Semen Euphorbiae 19 parts, Ocimum Basilicum 14 parts, Rhizoma Cimicifugae 6 parts, Radix Polygoni Multiflori 7 parts, Placenta Hominis 8 parts, Caulis Spatholobi 8 parts, Rhizoma Paridis 14 parts, Hirudo 4 parts, Stigma Maydis 9 parts, 8 parts, Radix Glycyrrhizae.

Further, described Chinese medicine composition is prepared according to following method:

(1) get each medical material according to components by weight percent, add the 10-12 water doubly of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the 12-13 water doubly of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the 14-15 water doubly of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merges 3 filtrates, 120 orders filter, and it is the thick paste of 1.28-1.33 that filtrate heating is concentrated into relative density at 60 DEG C, obtains Chinese medical concrete;

(2) Chinese medical concrete step (1) obtained is centrifugal under the rotating speed of 3000r/min; At 80 DEG C of spraying dry, obtain dry extract;

(3) dry extract obtained for step (2) is pulverized, add appropriate amount of auxiliary materials, make granule, powder, capsule or tablet.

The invention still further relates to a kind of described Chinese medicine composition and be used for the treatment of the application in liver-cancer medicine.

The Chinese medicine composition being used for the treatment of hepatocarcinoma provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Radix Notoginseng: the sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Rare Chinese medicine, raw with can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on the peculiar treasured be considered as by ancient Chinese medicine doctor in medicine, therefore has the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "." taste is micro-sweet and bitter, quite like the taste of Radix Ginseng for Radix Notoginseng." " all canes flutter trauma, and the dripping person of blood stasis, chew namely stopping of rotten net for catching birds or fish immediately, namely bruise person dissipate.If during by cane, first take one, two money, then the blood not centre of punch, should take it after cane especially, puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of cloudy blood system of fainting, therefore all disorders of blood can be controlled "." book on Chinese herbal medicine is looked for the truth " is recorded: " Radix Notoginseng, common people only know function hemostasis and pain-relieving.Hardly realize that pain aches work because of blood stasis, because applying loose, blood stops blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization." Radix Notoginseng can increase coronary flow, decreased heart rate, reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, improve microcirculation, removes the effect of smooth muscle spasm.

Rhizoma Gastrodiae: property is flat.Taste, sweet.Master enters Liver Channel.This product endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.For controlling key medicine that is dizzy, headache; Again in numb limbs and tense tendons, hands and feet caused by paralysis, rheumatic arthralgia, the good merchantable brand of muscles and bones contracture.

Herba Solani Nigri: be Solanaceae nightshade Herba Solani Nigri SolanumnigrumL., with all herbal medicine.Nature and flavor: cold, bitter, micro-sweet; Slightly poisonous.Effect: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Function: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Expelling wind and removing dampness, reducing swelling and alleviating pain.For rheumatalgia, wind syndrome of head pain, chest and hypochondrium, diarrhoea pain; Traumatic injury is controlled in external, swelling and pain due to blood stasis.

Fructus Akebiae: source: " decoction pieces is newly joined ".Nature and flavor: sweet, cold.Cure mainly: liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops.

Herba Taraxaci: be feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or the dry herb belonging to several plants together.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Fructus Citri Sarcodactylis: pungent, bitter, sour, temperature; Return liver, spleen, lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " Fructus Citri Sarcodactylis disappears cold syndrome of the stomach expectorant, controls gastric qi pain, the only cold pain in face, and middle circulation of qi promoting for tonifying liver warming the stomach, anti-nausea." " book on Chinese herbal medicine is new again ": " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.

Spica Prunellae: bitter in the mouth; Pungent; Cold in nature.Return liver; Gallbladder meridian.Liver heat removing and eyesight improving; Powder detoxifcation.Cure mainly corneal nebula photophobia; Ophthalmalgia; Have a headache dizzy; Tinnitus; Scrofula; Goiter; Acute mastitis; Mumps; Carbuncle furuncle and phyma poison; Acute, chronic hepatitis; Hypertension." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " liver-wind of dispelling, network of passing through.Control facial hemiparalysis, row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, loose scrofula, whole body tuberculosis.”

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.

Endothelium Corneum Gigeriae Galli is sweet, flat, returns spleen, stomach, small intestinal, urinary bladder channel, has effect of strengthening the spleen to promote digestion, only incontinence of urine, the inducing decomposition of calculi, is mainly used in food stagnation and does not disappear, vomiting dysentery, infantile malnutrition etc.

Fructus Ligustri Lucidi, sweet, bitter, cold.Return liver, kidney channel.Invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision." book on Chinese herbal medicine just ": " yin nourishing gas, Pingyin fire, separates dysphoria with smothery sensation hectic fever due to YIN-deficiency, and only sweating due to debility, quenches one's thirst, and stranguria with turbid discharge, and metrorrhagia, has blood in stool, hematuria, the erosion of vulva, anal fistula pain.Also clearing away liver-fire, can improving eyesight arresting lacrimation.”

Radix Ampelopsis: bitter, is slightly cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, expelling pus and promoting granulation.For carbuncle carbuncle on the back, furuncle, scrofula, burn and scald.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After small number of patients is taken medicine, there is the symptom such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enters spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.

Fructus Mume: property of medicine acid is puckery, flat.Return liver, spleen, lung, large intestine channel; Effect: astringing lung-QI and relieving cough, relieving diarrhea with astringents, relieving pain by calming ascaris, promoting the production of body fluid to quench thirst.

Cortex Phellodendri: this product is the dry bark of rutaceae wampee PhellodendronchinenseSchneid..Bitter in the mouth, cold in nature, energy heat clearing and damp drying, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels damp-edema." medication heart method " records Cortex Phellodendri: " control the unbearably painful person of skin ulcer." Cortex Phellodendri contains large number of biological alkali components, has the antibacterial action of wide spectrum, can block nerves joint, nervus centralis is had to the effect of suppression.

Caulis Bambusae In Taeniam, for Phallaceae fungus bamboo claim, the sporophore of short-skirted veiled lady, sweet, micro-hardship, cool in nature, boosting qi and nourishing yin; Nourishing the lung to arrest cough; Clearing away heat-damp and promoting diuresis.Main deficiency of the lung heat syndrome cough; Laryngitis; Dysentery; Leucorrhea; Hypertension; Hyperlipemia.

Radix Arnebiae (Radix Lithospermi): cold in nature is sweet in the mouth, salty.GUIXIN, Liver Channel.Its function cures mainly: removing heat from blood, invigorates blood circulation, removing toxic substances rash.

Herba Sedi: source: the fresh or dry herb of crassulaceae plants Herba Sedi SedumsarmentosumBunge.Summer, Qiu Erji gather, removing impurity.Using fresh herb or drying.Nature and flavor: sweet, light, cool.Gui Jing: return liver, gallbladder, small intestine meridian.Function cures mainly: eliminating damp-heat, removing toxic substances.For jaundice due to damp-heat, dysuria, carbuncle skin infection, acute hepatitis, chronic hepatitis.

Herba Salviae Chinensis, micro-hardship, flat.Function cures mainly: heat-clearing and toxic substances removing, invigorating blood circulation analgesia.For icterohepatitis, cancer, nephritis, leucorrhea, dysmenorrhea, tuberculous lymphadenitis, elephantiasis; Facial paralysis is controlled in external, mastitis, furuncle and phyma.

Rhizoma Imperatae, sweet, cold.Return lung, stomach, urinary bladder channel.Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Semen Plantaginis: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, improving eyesight, eliminates the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.

Semen Euphorbiae: acrid in the mouth, warm in nature.Return liver, kidney, large intestine channel.Can to relieve oedema or abdominal distension through diuresis or purgation detumescence, broken disease parasite killing.Swelling of harnessing the river is full, phlegm retention, dyspepsia, lump in the abdomen; Women's amenorrhea; Scabies sore, Serpentis stings, warty vegetation.Tool antitumor action.To stagnate distension, constipation and anuresis, blood stasis amenorrhea for edema, phlegm retention.

Ocimum Basilicum: acrid in the mouth, warm in nature.Relieving the exterior syndrome by diaphoresis, expelling wind and removing dampness, eliminating stasis to stop pain.For anemofrigid cold, headache, pipe abdomen fullness, dyspepsia, stomachache, enteritis, diarrhea, treating swelling and pain by traumatic injury, rheumatic arthritis; Venom is controlled in external, eczema, dermatitis.

Rhizoma Cimicifugae, pungent, micro-sweet, be slightly cold.Return lung, spleen, stomach, large intestine channel.Function cures mainly: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, uterine prolapse.

Radix Polygoni Multiflori bitter in the mouth, sweet; Puckery, slightly warm in nature, returns liver, kidney channel.Mainly contain nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, detoxify.Cure mainly blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body void, rubella pruritus, carbuncle sore, scrofula, hemorrhoid etc.

Placenta Hominis: sweet, salty, temperature.GUIXIN, lung, kidney channel.Effect with cure mainly: the kidney warming mends essence, benefiting QI and nourishing blood.Win thin for asthenia, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia.

Caulis Spatholobi: be the dry rattan of pulse family Leguminosae plant spatholobus suberectus SpatholobussuberectusDunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Effect: enrich blood, invigorates blood circulation, dredging collateral.

Rhizoma Paridis: bitter in the mouth, cold nature, enters Liver Channel.Function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and determine convulsion; Cure mainly digestive tract carcinoma, pulmonary carcinoma, the cerebral tumor and malignant lymphoma, the clinical stagnant malignant lymphoma of pyretic toxicity harmony, pulmonary carcinoma, nasopharyngeal carcinoma, the cerebral tumor and the digestive system tumor of being used for is as gastric cancer, the esophageal carcinoma, hepatocarcinoma etc.

Hirudo: salty in the mouth is bitter, property is put down, and enters Liver Channel, enters blood, removing blood stasis power is strong, can cure the wound by the meridian dredging ， Xiao wei.Shennong's Herbal: " lead by stagnant blood, blood stasis, removing blood stasis abdominal mass, gather ... ".This product mainly contains a kind of anticoagulative substance-hirudin containing in protein, heparin, antithrombase, fresh Hirudo saliva.In addition, still containing various trace elements such as sodium, potassium, calcium.Pharmacological research proves: this product has anti thrombotic action, can not only the formation of anti-tampon, can also thrombus, change fibrinogen can be suppressed to be fibrin, and the activity of energy factor anticoagulant and the platelet response of thrombin induction, there is very strong anticoagulation.Can surface activity of blood platelet be reduced, anticoagulant, can hemorheology be improved; can reduce blood fat, disappear atheromatous plaque, alleviates surrounding tissue inflammatory reaction; improve blood circulation, protection cerebral tissue, increase cardiac muscle nutritional blood flow and promote the effects such as neurological functional recovery.

Stigma Maydis: diuresis, expels the heat-evil, suppressing the hyperactive liver, function of gallbladder promoting.Control oedema due to nephritis, beriberi, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis and epistaxis, nasal sinusitis, acute mastitis.The present invention selects style and the stigma of grass Semen Maydis ZeamaysL..

Radix Glycyrrhizae is the dry root of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL..Sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Hepatocarcinoma belongs to modern diseases, Chinese medicine is not to the disease appellation of hepatocarcinoma, but the traditional Chinese medical science is remote to hepatocarcinoma understanding, the category such as " lump in the abdomen ", " gathering ", " expansion ", " jaundice ", " hematemesis " of the traditional Chinese medical science can be belonged to, be one of the poorest malignant tumor of current prognosis, be called as " cancer in cancer ".The generation of primary hepatocarcinoma is on the basis of positive QI-insufficiency, diseases caused by exogenous pathogenic factor Shi Re Bing Pian; Or drinking and eating irregularly; Or disorder of emotion, finally cause visceral dysfunction, expectorant knot is wet poly-, knot in pyretic toxicity, qi depression to blood stasis, and mutual cementing difficultyization, gathers in liver, in the course of time, sends out as hepatocarcinoma." a Principle and Prohibition for Medical profession distension syndrome section " is said " distension syndrome also not outer water wrap up in, depressed, blood stasis ", as can be seen here, wet, poison, the stasis of blood, void can be summarized as the basic pathology feature of primary hepatocarcinoma.Clinically, according to the symptom of hepatocarcinoma, hepatocarcinoma is generally divided into the disease types such as stagnation of liver-QI with deficiency of the spleen, qi depression to blood stasis, spleen deficiency and blood stasis, dampness-heat in the liver and gallbladder, yin asthenia generating intrinsic heat, deficiency of spleen-YANG and kidneyYANG.In method for the treatment of, in early days based on blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, soothing the liver circulation of qi promoting, for the purpose of dispeling disease and evil; Mid-term lays equal stress on invigorating the spleen and regulating the stomach, regulating qi to disperse stagnation eliminating stagnation, takes into account strengthening vital QI to eliminate pathogenic factors; Spleen invigorating in late period QI invigorating is main, furthermore stomach function regulating, relieving distension, diuretic, jaundice eliminating, and protects healthy energy attach most importance to turn round and look at.

In Chinese medicine composition of the present invention, with Fructus Akebiae, Fructus Citri Sarcodactylis, Fructus Ligustri Lucidi, Radix Et Caulis Acanthopanacis Senticosi, Caulis Bambusae In Taeniam, Ocimum Basilicum, Radix Polygoni Multiflori, Placenta Hominis for monarch drug, liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, benefiting QI and nourishing blood, expelling wind and removing dampness, eliminating stasis to stop pain; With Herba Solani Nigri, Rhizoma Polygoni Cuspidati, Radix Ampelopsis, Herb Gynostemmae Pentaphylli, Cortex Phellodendri, Herba Sedi, Rhizoma Cimicifugae for ministerial drug, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, dampness diuretic; With Stigma Maydis, Rhizoma Gastrodiae, Herba Taraxaci, Spica Prunellae, the Rhizoma Pinelliae, Herba Salviae Chinensis, Rhizoma Paridis for adjuvant drug, endogenous wind stopping relieving convulsion, dispelling wind and removing obstruction in the collateral, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, invigorating blood circulation analgesia; With Radix Notoginseng, Rhizoma Curcumae, Endothelium Corneum Gigeriae Galli, Fructus Mume, Radix Arnebiae (Radix Lithospermi), Rhizoma Imperatae, Semen Plantaginis, Semen Euphorbiae, Caulis Spatholobi, Hirudo for making medicine, promoting blood circulation to restore menstrual flow, removing food stagnancy pain relieving, removing toxic substances rash, clearing away heat and promoting diuresis; With Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines are coordinated, promotes mutually, mutually coordinate, thus reach the effects such as liver-smoothing, qi-regulating, dissipating phlegm and resolving masses, benefiting QI and nourishing blood, promoting blood circulation to restore menstrual flow, blood stasis dispelling diuresis, more excellent therapeutic effect is shown for hepatocarcinoma.

Selected by the Chinese medicine composition being used for the treatment of hepatocarcinoma of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine theory, there is effect of liver-smoothing, qi-regulating, dissipating phlegm and resolving masses, benefiting QI and nourishing blood, promoting blood circulation to restore menstrual flow, blood stasis dispelling diuresis, evident in efficacy, without bad and toxic and side effects, easy to prepare, cheap, be suitable for clinical application.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.

Embodiment 1:

A kind of Chinese medicine composition being used for the treatment of hepatocarcinoma of the present invention, get following traditional Chinese medicine raw medicine: Radix Notoginseng 5 parts, 1 part, Rhizoma Gastrodiae, Herba Solani Nigri 12 parts, Rhizoma Curcumae 10 parts, Fructus Akebiae 9 parts, Herba Taraxaci 15 parts, Fructus Citri Sarcodactylis 15 parts, Spica Prunellae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Ligustri Lucidi 14 parts, Radix Ampelopsis 9 parts, Herb Gynostemmae Pentaphylli 6 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 1 part, Cortex Phellodendri 6 parts, Caulis Bambusae In Taeniam 8 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Herba Sedi 15 parts, Herba Salviae Chinensis 5 parts, Rhizoma Imperatae 3 parts, Semen Plantaginis 5 parts, Semen Euphorbiae 12 parts, Ocimum Basilicum 16 parts, Rhizoma Cimicifugae 3 parts, Radix Polygoni Multiflori 12 parts, Placenta Hominis 10 parts, Caulis Spatholobi 5 parts, Rhizoma Paridis 16 parts, Hirudo 10 parts, Stigma Maydis 8 parts, 10 parts, Radix Glycyrrhizae.

Wherein, the preparation method of described Chinese medicine composition is:

(1) get each medical material according to components by weight percent, add the 10-12 water doubly of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the 12-13 water doubly of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the 14-15 water doubly of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merges 3 filtrates, 120 orders filter, and it is the thick paste of 1.28-1.33 that filtrate heating is concentrated into relative density at 60 DEG C, obtains Chinese medical concrete;

(2) Chinese medical concrete step (1) obtained is centrifugal under the rotating speed of 3000r/min; At 80 DEG C of spraying dry, obtain dry extract;

(3) dry extract obtained for step (2) is pulverized, add appropriate amount of auxiliary materials, make granule, powder, capsule or tablet.

Embodiment 2:

A kind of Chinese medicine composition being used for the treatment of hepatocarcinoma of the present invention, get following traditional Chinese medicine raw medicine: Radix Notoginseng 3 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 17 parts, Rhizoma Curcumae 12 parts, Fructus Akebiae 4 parts, Herba Taraxaci 20 parts, Fructus Citri Sarcodactylis 10 parts, Spica Prunellae 12 parts, Rhizoma Polygoni Cuspidati 2 parts, Endothelium Corneum Gigeriae Galli 7 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 15 parts, Herb Gynostemmae Pentaphylli 3 parts, Radix Et Caulis Acanthopanacis Senticosi 13 parts, the Rhizoma Pinelliae 3 parts, Fructus Mume 3 parts, Cortex Phellodendri 4 parts, Caulis Bambusae In Taeniam 10 parts, Radix Arnebiae (Radix Lithospermi) 4 parts, Herba Sedi 13 parts, Herba Salviae Chinensis 6 parts, Rhizoma Imperatae 4 parts, Semen Plantaginis 8 parts, Semen Euphorbiae 20 parts, Ocimum Basilicum 10 parts, Rhizoma Cimicifugae 8 parts, Radix Polygoni Multiflori 5 parts, Placenta Hominis 5 parts, Caulis Spatholobi 10 parts, Rhizoma Paridis 13 parts, Hirudo 3 parts, Stigma Maydis 13 parts, 5 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

Embodiment 3:

A kind of Chinese medicine composition being used for the treatment of hepatocarcinoma of the present invention, get following traditional Chinese medicine raw medicine: Radix Notoginseng 4 parts, 2 parts, Rhizoma Gastrodiae, Herba Solani Nigri 13 parts, Rhizoma Curcumae 7 parts, Fructus Akebiae 5 parts, Herba Taraxaci 18 parts, Fructus Citri Sarcodactylis 11 parts, Spica Prunellae 9 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 6 parts, Fructus Ligustri Lucidi 12 parts, Radix Ampelopsis 13 parts, Herb Gynostemmae Pentaphylli 4 parts, Radix Et Caulis Acanthopanacis Senticosi 9 parts, the Rhizoma Pinelliae 4 parts, Fructus Mume 2 parts, Cortex Phellodendri 5 parts, Caulis Bambusae In Taeniam 12 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Herba Sedi 12 parts, Herba Salviae Chinensis 9 parts, Rhizoma Imperatae 4 parts, Semen Plantaginis 7 parts, Semen Euphorbiae 13 parts, Ocimum Basilicum 11 parts, Rhizoma Cimicifugae 4 parts, Radix Polygoni Multiflori 6 parts, Placenta Hominis 6 parts, Caulis Spatholobi 6 parts, Rhizoma Paridis 14 parts, Hirudo 5 parts, Stigma Maydis 10 parts, 6 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

Embodiment 4:

A kind of Chinese medicine composition being used for the treatment of hepatocarcinoma of the present invention, get following traditional Chinese medicine raw medicine: Radix Notoginseng 3 parts, 1 part, Rhizoma Gastrodiae, Herba Solani Nigri 16 parts, Rhizoma Curcumae 8 parts, Fructus Akebiae 8 parts, Herba Taraxaci 16 parts, Fructus Citri Sarcodactylis 14 parts, Spica Prunellae 11 parts, Rhizoma Polygoni Cuspidati 3 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Ligustri Lucidi 13 parts, Radix Ampelopsis 14 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Rhizoma Pinelliae 3 parts, Fructus Mume 1 part, Cortex Phellodendri 4 parts, Caulis Bambusae In Taeniam 11 parts, Radix Arnebiae (Radix Lithospermi) 4 parts, Herba Sedi 14 parts, Herba Salviae Chinensis 8 parts, Rhizoma Imperatae 3 parts, Semen Plantaginis 6 parts, Semen Euphorbiae 17 parts, Ocimum Basilicum 15 parts, Rhizoma Cimicifugae 7 parts, Radix Polygoni Multiflori 11 parts, Placenta Hominis 10 parts, Caulis Spatholobi 9 parts, Rhizoma Paridis 13 parts, Hirudo 7 parts, Stigma Maydis 11 parts, 10 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

Embodiment 5:

A kind of Chinese medicine composition being used for the treatment of hepatocarcinoma of the present invention, get following traditional Chinese medicine raw medicine: Radix Notoginseng 5 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 15 parts, Rhizoma Curcumae 9 parts, Fructus Akebiae 7 parts, Herba Taraxaci 19 parts, Fructus Citri Sarcodactylis 13 parts, Spica Prunellae 10 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 11 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 3 parts, Cortex Phellodendri 6 parts, Caulis Bambusae In Taeniam 9 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Herba Sedi 12 parts, Herba Salviae Chinensis 7 parts, Rhizoma Imperatae 5 parts, Semen Plantaginis 9 parts, Semen Euphorbiae 15 parts, Ocimum Basilicum 12 parts, Rhizoma Cimicifugae 5 parts, Radix Polygoni Multiflori 9 parts, Placenta Hominis 8 parts, Caulis Spatholobi 8 parts, Rhizoma Paridis 14 parts, Hirudo 9 parts, Stigma Maydis 12 parts, 8 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

Embodiment 6:

A kind of Chinese medicine composition being used for the treatment of hepatocarcinoma of the present invention, get following traditional Chinese medicine raw medicine: Radix Notoginseng 5 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 14 parts, Rhizoma Curcumae 9 parts, Fructus Akebiae 6 parts, Herba Taraxaci 17 parts, Fructus Citri Sarcodactylis 13 parts, Spica Prunellae 10 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 11 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 3 parts, Cortex Phellodendri 3 parts, Caulis Bambusae In Taeniam 8 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Herba Sedi 15 parts, Herba Salviae Chinensis 7 parts, Rhizoma Imperatae 2 parts, Semen Plantaginis 4 parts, Semen Euphorbiae 19 parts, Ocimum Basilicum 14 parts, Rhizoma Cimicifugae 6 parts, Radix Polygoni Multiflori 7 parts, Placenta Hominis 8 parts, Caulis Spatholobi 8 parts, Rhizoma Paridis 14 parts, Hirudo 4 parts, Stigma Maydis 9 parts, 8 parts, Radix Glycyrrhizae.

Preparation method is with embodiment 1.

Acute toxicity test:

Test material: Kunming mouse 60, body weight 22-25g.Medicine: the medicinal liquid that the tablet that the embodiment of the present invention 3 obtains is made, containing 0.037mg/ml.

Method: LD50 calculates: adopt improvement karber's method, mice is divided into 4 groups at random, often organize 15, medicinal liquid agent adding distil water is dissolved, is made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 19.3,14.5,12.4 to dosage by crude drug amount, 9.3,7.1 (g.kg-1), in animal fasting (can't help water) after 24 hours, administration at twice in a day (interval half an hour), each 0.6ml, observes animal dead situation.

Result of the test: in LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18.6g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, to observation post administration 14 days, none was dead for mice, main organs no abnormality seen, also have no other obviously abnormal, within the 14th day, put to death and cut open inspection some animals, perusal main organs no abnormality seen.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18.6g/Kg.d.

Six months long term toxicity tests: weigh weekly once during administration, every day claims appetite, without dead or moribund animals, result mice hair color is bright and clean, and behavioral activity, glandular secretion, breathing, feces character are all normal.Pathologic finding is pointed out, to various internal organs without obvious drug-induced pathological change.

Clinical reasoning:

In order to verify the effect of Chinese medicine composition of the present invention, in May ,-2014 in April, 2013, inpatients with hepatocarcinoma 180 example is randomly drawed in outpatient service place, patient is divided into two groups at random, treatment group 90 example, wherein male 42 example, women 48 example, 29 years old ~ 61 years old age, 45.5 ± 2.3 years old mean age.Matched group 90 example, wherein male 44 example, women 46 example, 31 years old ~ 63 years old age, 48.1 ± 4.1 years old mean age.The course of disease, the degrees of symptoms of two groups of cases are basically identical, without significant difference, have comparability.

Diagnostic criteria

According to the diagnosing cancer of liver standard that the 4th national hepatocarcinoma academic conference is worked out.

(1) pathological diagnosis: liver inner disease foci pathological examination turns out to be primary hepatocarcinoma.

(2) clinical diagnosis: comprise AFP > 400 μ g/L, activeness hepatopathy, gestation, system genitale embryo source property tumor and secondary liver cancer can be got rid of, and can touch hard and have the liver of lump or imaging examination to have the occupying lesion person of liver cancer characteristic; AFP≤400 μ g/L, two kinds of imaging examinations confirm there is liver cancer characteristic occupying lesion or has two kinds of liver cancer markers (alpha-fetoprotein variant, abnormal prothrombin, glutamyl transpeptidase isodynamic enzyme II test and alpha-L-fucosidase etc.) positive and a kind of imaging examination to find that there is liver cancer characteristic occupying lesion person; There is the clinical manifestation of hepatocarcinoma and have the extrahepatic metastases stove of affirmative (comprise macroscopic bloody ascites or find cancerous cell wherein) and the person that can get rid of secondary liver cancer.

Enter group standard

The diagnostic criteria of the primary hepatocarcinoma that " new Chinese medicine guideline of clinical investigations " that all cases all meet Ministry of Public Health formulation specifies.

(1) be clearly Patients with Primary, age 18-75 year, estimate life cycle more than 2 months persons;

(2) focus that can clearly measure or assess is had at least;

(3) patient's informed consent, has good compliance;

(4) do not accept chemotherapy, or after Radiotherapy chemotherapy at least 4 week, in 4 weeks, do not carry out major surgery;

(5) do not accept other drug clinical and experimental study person simultaneously.

Exclusion standard

(1) person that has Gastrointestinal Obstruction;

(2) clear and definite central nervous system's transferrer is had;

(3) trimester of pregnancy;

(4) intentionally, lung, kidney severe complication person;

(5) other effective therapists are just being accepted;

(6) Informed Consent Form can not be understood, cannot correction person, or there is the patient of uppity mental sickness history.

The 180 routine patients entering group research all meet the regulation of above-mentioned diagnostic criteria, inclusion criteria and exclusion standard.

Therapeutic Method

Treatment group takes tablet prepared by embodiment 3, each 3, every day 3 times.

Matched group takes other drug (as conventional medicines such as Nexavar, huaier granules and Xihuang capsules).

Within 30 days, be 1 course for the treatment of, follow up a case by regular visits to 3 courses for the treatment of continuously, death treatment nature terminates.

Outcome measure

" new Chinese medicine guideline of clinical investigations " specified standard of working out by Ministry of Public Health performs.

Complete incidence graph: cancer disappears and continues more than 1 month;

Partial rcsponse: the maximum orthogonal diameter product of cancer 2 reduces more than 50%, and continue more than 1 month;

Stable: the maximum orthogonal diameter product of cancer 2 reduces less than more than 50%, increases and is no more than 25%, and continue more than 1 month;

Worsen: the maximum orthogonal diameter product of cancer 2 increases above 25%.

Life quality evaluation criteria

By Kamofsky scoring, carry out comparing before and after treatment.

Effective: after treatment, to increase by 20 points than before treatment;

Effective: after treatment, to increase by 10 points than before treatment;

Invalid: not reach above standard person.

Date processing

All measurement data data are used represent.Adopt the capable t inspection of SPSS13.0 software, P<0.05 is that difference has statistical significance.

Result

Cancer alleviates situation

Each group of cancer alleviates situation in table 1.Basicly stable or the partial rcsponse of visible treatment group focus, total effective rate is significantly higher than matched group (P<0.05).

Table 1 respectively group cancer alleviates situation

Group

Number of cases

Complete incidence graph

Partial rcsponse

Stable

Worsen

Effectively total

Treatment group

90

0

5(5.6％)

76(84.4％)

9(10％)

81(90％)

Matched group

90

0

0

49(54.4％)

41(45.6％)

42(54.4％)

Quality of life improves situation

Each group for the treatment of Life For The Residents of Three Gorges Reservoir Before index of correlation is in table 2.

After each group for the treatment of, index of correlation is all significantly improved (P<0.05) every quality of life.Treatment group is compared with matched group, and Kamofsky scoring after treatment, VAS pain scores, dining every day amount all have significant difference (P<0.05).

Table 2 is group treatment Life For The Residents of Three Gorges Reservoir Before index of correlation respectively

Note: *, compares with before treatment, P<0.05; #, compares with matched group, P<0.05.

Here is the model case of inventor's daily clinic contact:

Case 1:

Chen, man, 34 years old, people from South, Qingdao City.Patient's in JIUYUE, 2012 self-induction decreased food intake is become thin weak, and the hepatic region enclosed mass hard severe pain several months, through the People's Hospital's liver scanning, AFP checks and is diagnosed as hepatocarcinoma enclosed mass 8 × 10cm, and because patient body difference is become thin, enclosed mass is cumulative, cannot chemotherapy, on January 5th, 2013 starts the granule taking Chinese medicine composition of the present invention, one day twice, each one bag, sooner or later one after each meal, after one month, enclosed mass obviously reduces, and the state of an illness significantly takes a turn for the better, and appetite is cumulative.Continue medication treatment, after 4 months, liver scanning check enclosed mass disappears, and recovers normal work capacity.

Case 2:

River, female, 46 years old, people from Lixia District, Jinan City.The long-term inappetence of patient, poor appetite, abdominal distention, xanthochromia, limbs fatigue, hepatocarcinoma in mid-term is diagnosed as through certain examination in hospital, focus is directly through 3.5cm, and in June, 2014 starts the tablet taking the embodiment of the present invention 6, one day twice, each two panels, sooner or later one after each meal, treat symptom after month and be clearly better, tumor block reduces 3cm.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. be used for the treatment of a Chinese medicine composition for hepatocarcinoma, it is characterized in that: the crude drug of described Chinese medicine composition is made up of Radix Notoginseng, Rhizoma Gastrodiae, Herba Solani Nigri, Rhizoma Curcumae, Fructus Akebiae, Herba Taraxaci, Fructus Citri Sarcodactylis, Spica Prunellae, Rhizoma Polygoni Cuspidati, Endothelium Corneum Gigeriae Galli, Fructus Ligustri Lucidi, Radix Ampelopsis, Herb Gynostemmae Pentaphylli, Radix Et Caulis Acanthopanacis Senticosi, the Rhizoma Pinelliae, Fructus Mume, Cortex Phellodendri, Caulis Bambusae In Taeniam, Radix Arnebiae (Radix Lithospermi), Herba Sedi, Herba Salviae Chinensis, Rhizoma Imperatae, Semen Plantaginis, Semen Euphorbiae, Ocimum Basilicum, Rhizoma Cimicifugae, Radix Polygoni Multiflori, Placenta Hominis, Caulis Spatholobi, Rhizoma Paridis, Hirudo, Stigma Maydis, Radix Glycyrrhizae.

2. the Chinese medicine composition being used for the treatment of hepatocarcinoma according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 3-5 part, Rhizoma Gastrodiae 1-3 part, Herba Solani Nigri 12-17 part, Rhizoma Curcumae 7-12 part, Fructus Akebiae 4-9 part, Herba Taraxaci 15-20 part, Fructus Citri Sarcodactylis 10-15 part, Spica Prunellae 8-12 part, Rhizoma Polygoni Cuspidati 2-5 part, Endothelium Corneum Gigeriae Galli 3-7 part, Fructus Ligustri Lucidi 11-14 part, Radix Ampelopsis 9-15 part, Herb Gynostemmae Pentaphylli 3-6 part, Radix Et Caulis Acanthopanacis Senticosi 8-13 part, Rhizoma Pinelliae 3-5 part, Fructus Mume 1-3 part, Cortex Phellodendri 3-6 part, Caulis Bambusae In Taeniam 8-13 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Herba Sedi 11-15 part, Herba Salviae Chinensis 5-10 part, Rhizoma Imperatae 2-5 part, Semen Plantaginis 4-9 part, Semen Euphorbiae 12-20 part, Ocimum Basilicum 10-16 part, Rhizoma Cimicifugae 3-8 part, Radix Polygoni Multiflori 5-12 part, Placenta Hominis 5-10 part, Caulis Spatholobi 5-10 part, Rhizoma Paridis 13-16 part, Hirudo 3-10 part, Stigma Maydis 8-13 part, Radix Glycyrrhizae 5-10 part.

3. the Chinese medicine composition being used for the treatment of hepatocarcinoma according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 5 parts, 1 part, Rhizoma Gastrodiae, Herba Solani Nigri 12 parts, Rhizoma Curcumae 10 parts, Fructus Akebiae 9 parts, Herba Taraxaci 15 parts, Fructus Citri Sarcodactylis 15 parts, Spica Prunellae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Ligustri Lucidi 14 parts, Radix Ampelopsis 9 parts, Herb Gynostemmae Pentaphylli 6 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 1 part, Cortex Phellodendri 6 parts, Caulis Bambusae In Taeniam 8 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Herba Sedi 15 parts, Herba Salviae Chinensis 5 parts, Rhizoma Imperatae 3 parts, Semen Plantaginis 5 parts, Semen Euphorbiae 12 parts, Ocimum Basilicum 16 parts, Rhizoma Cimicifugae 3 parts, Radix Polygoni Multiflori 12 parts, Placenta Hominis 10 parts, Caulis Spatholobi 5 parts, Rhizoma Paridis 16 parts, Hirudo 10 parts, Stigma Maydis 8 parts, 10 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition being used for the treatment of hepatocarcinoma according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 3 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 17 parts, Rhizoma Curcumae 12 parts, Fructus Akebiae 4 parts, Herba Taraxaci 20 parts, Fructus Citri Sarcodactylis 10 parts, Spica Prunellae 12 parts, Rhizoma Polygoni Cuspidati 2 parts, Endothelium Corneum Gigeriae Galli 7 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 15 parts, Herb Gynostemmae Pentaphylli 3 parts, Radix Et Caulis Acanthopanacis Senticosi 13 parts, the Rhizoma Pinelliae 3 parts, Fructus Mume 3 parts, Cortex Phellodendri 4 parts, Caulis Bambusae In Taeniam 10 parts, Radix Arnebiae (Radix Lithospermi) 4 parts, Herba Sedi 13 parts, Herba Salviae Chinensis 6 parts, Rhizoma Imperatae 4 parts, Semen Plantaginis 8 parts, Semen Euphorbiae 20 parts, Ocimum Basilicum 10 parts, Rhizoma Cimicifugae 8 parts, Radix Polygoni Multiflori 5 parts, Placenta Hominis 5 parts, Caulis Spatholobi 10 parts, Rhizoma Paridis 13 parts, Hirudo 3 parts, Stigma Maydis 13 parts, 5 parts, Radix Glycyrrhizae.

5. the Chinese medicine composition being used for the treatment of hepatocarcinoma according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 4 parts, 2 parts, Rhizoma Gastrodiae, Herba Solani Nigri 13 parts, Rhizoma Curcumae 7 parts, Fructus Akebiae 5 parts, Herba Taraxaci 18 parts, Fructus Citri Sarcodactylis 11 parts, Spica Prunellae 9 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 6 parts, Fructus Ligustri Lucidi 12 parts, Radix Ampelopsis 13 parts, Herb Gynostemmae Pentaphylli 4 parts, Radix Et Caulis Acanthopanacis Senticosi 9 parts, the Rhizoma Pinelliae 4 parts, Fructus Mume 2 parts, Cortex Phellodendri 5 parts, Caulis Bambusae In Taeniam 12 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Herba Sedi 12 parts, Herba Salviae Chinensis 9 parts, Rhizoma Imperatae 4 parts, Semen Plantaginis 7 parts, Semen Euphorbiae 13 parts, Ocimum Basilicum 11 parts, Rhizoma Cimicifugae 4 parts, Radix Polygoni Multiflori 6 parts, Placenta Hominis 6 parts, Caulis Spatholobi 6 parts, Rhizoma Paridis 14 parts, Hirudo 5 parts, Stigma Maydis 10 parts, 6 parts, Radix Glycyrrhizae.

6. the Chinese medicine composition being used for the treatment of hepatocarcinoma according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 3 parts, 1 part, Rhizoma Gastrodiae, Herba Solani Nigri 16 parts, Rhizoma Curcumae 8 parts, Fructus Akebiae 8 parts, Herba Taraxaci 16 parts, Fructus Citri Sarcodactylis 14 parts, Spica Prunellae 11 parts, Rhizoma Polygoni Cuspidati 3 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Ligustri Lucidi 13 parts, Radix Ampelopsis 14 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, the Rhizoma Pinelliae 3 parts, Fructus Mume 1 part, Cortex Phellodendri 4 parts, Caulis Bambusae In Taeniam 11 parts, Radix Arnebiae (Radix Lithospermi) 4 parts, Herba Sedi 14 parts, Herba Salviae Chinensis 8 parts, Rhizoma Imperatae 3 parts, Semen Plantaginis 6 parts, Semen Euphorbiae 17 parts, Ocimum Basilicum 15 parts, Rhizoma Cimicifugae 7 parts, Radix Polygoni Multiflori 11 parts, Placenta Hominis 10 parts, Caulis Spatholobi 9 parts, Rhizoma Paridis 13 parts, Hirudo 7 parts, Stigma Maydis 11 parts, 10 parts, Radix Glycyrrhizae.

7. the Chinese medicine composition being used for the treatment of hepatocarcinoma according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 5 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 15 parts, Rhizoma Curcumae 9 parts, Fructus Akebiae 7 parts, Herba Taraxaci 19 parts, Fructus Citri Sarcodactylis 13 parts, Spica Prunellae 10 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 11 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 3 parts, Cortex Phellodendri 6 parts, Caulis Bambusae In Taeniam 9 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Herba Sedi 12 parts, Herba Salviae Chinensis 7 parts, Rhizoma Imperatae 5 parts, Semen Plantaginis 9 parts, Semen Euphorbiae 15 parts, Ocimum Basilicum 12 parts, Rhizoma Cimicifugae 5 parts, Radix Polygoni Multiflori 9 parts, Placenta Hominis 8 parts, Caulis Spatholobi 8 parts, Rhizoma Paridis 14 parts, Hirudo 9 parts, Stigma Maydis 12 parts, 8 parts, Radix Glycyrrhizae.

8. the Chinese medicine composition being used for the treatment of hepatocarcinoma according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Notoginseng 5 parts, 3 parts, Rhizoma Gastrodiae, Herba Solani Nigri 14 parts, Rhizoma Curcumae 9 parts, Fructus Akebiae 6 parts, Herba Taraxaci 17 parts, Fructus Citri Sarcodactylis 13 parts, Spica Prunellae 10 parts, Rhizoma Polygoni Cuspidati 4 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Ligustri Lucidi 11 parts, Radix Ampelopsis 11 parts, Herb Gynostemmae Pentaphylli 5 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, the Rhizoma Pinelliae 5 parts, Fructus Mume 3 parts, Cortex Phellodendri 3 parts, Caulis Bambusae In Taeniam 8 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Herba Sedi 15 parts, Herba Salviae Chinensis 7 parts, Rhizoma Imperatae 2 parts, Semen Plantaginis 4 parts, Semen Euphorbiae 19 parts, Ocimum Basilicum 14 parts, Rhizoma Cimicifugae 6 parts, Radix Polygoni Multiflori 7 parts, Placenta Hominis 8 parts, Caulis Spatholobi 8 parts, Rhizoma Paridis 14 parts, Hirudo 4 parts, Stigma Maydis 9 parts, 8 parts, Radix Glycyrrhizae.

9., according to the arbitrary described Chinese medicine composition being used for the treatment of hepatocarcinoma of claim 3-8, it is characterized in that: described Chinese medicine composition is prepared according to following method:

(1) get each medical material according to components by weight percent, add the 10-12 water doubly of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the 12-13 water doubly of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the 14-15 water doubly of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merges 3 filtrates, 120 orders filter, and it is the thick paste of 1.28-1.33 that filtrate heating is concentrated into relative density at 60 DEG C, obtains Chinese medical concrete;

(2) Chinese medical concrete step (1) obtained is centrifugal under the rotating speed of 3000r/min; At 80 DEG C of spraying dry, obtain dry extract;

(3) dry extract obtained for step (2) is pulverized, add appropriate amount of auxiliary materials, make granule, powder, capsule or tablet.

10. the Chinese medicine composition being used for the treatment of hepatocarcinoma as described in as arbitrary in claim 1-9 is being used for the treatment of the application in liver-cancer medicine.