CN104524397A - Traditional Chinese medicine composition for assisted rehabilitation of stroke and preparation method of composition - Google Patents

Traditional Chinese medicine composition for assisted rehabilitation of stroke and preparation method of composition Download PDF

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CN104524397A
CN104524397A CN201510063034.XA CN201510063034A CN104524397A CN 104524397 A CN104524397 A CN 104524397A CN 201510063034 A CN201510063034 A CN 201510063034A CN 104524397 A CN104524397 A CN 104524397A
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parts
chinese medicine
herba
radix
fructus
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王洋
李艳
郑秀杰
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
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    • A61K9/2022Organic macromolecular compounds
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    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention relates to a traditional Chinese medicine composition for assisted rehabilitation of stroke. The traditional Chinese medicine active ingredients of the composition are prepared from the following raw materials in parts by weight: 2-10 parts of golden cypress, 5-8 parts of rhizome of swordlike atractylodes, 7-20 parts of rhizoma smilacis glabrae, 4-9 parts of plantain herb, 3-10 parts of oriental waterplantain rhizome, 5-12 parts of dandelion, 6-10 parts of honeysuckle, 3-14 parts of indigowoad root, 10-20 parts of scandent schefflera stem and leaf, 4-20 parts of weeping forsythia capsule, 6-8 parts of dwarf lilyturf tuber, 3-6 parts of cape jasmine, 2-7 parts of chicken gizzard-membrane, 8-10 parts of cherokee rose fruit, 2-5 parts of fragrant solomonseal rhizome, 7-10 parts of tortoise shell, 3-6 parts of sharpleaf galangal fruit, 1-8 parts of clematis root, 4-7 parts of cassia seed, 3-6 parts of herb of spicate clerodendranthus, 4-9 parts of fineleaf schizonepeta herb and 10-20 parts of snake gall. The traditional Chinese medicine composition is used for treating dysfunctional diseases caused by cranial nerves injuries due to stroke. In the treatment process, the traditional Chinese medicine has the advantages of convenience for taking, low price, no adverse reaction and the like, and is worthy of clinical popularization.

Description

A kind of Chinese medicine composition for apoplexy recovering aid and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, be specifically related to a kind of Chinese medicine composition for the treatment of gout and preparation method thereof.
Background technology
Apoplexy is sickness rate and the higher disease of mortality rate in world wide, is threaten one of human life and the most serious healthy disease.Its mortality rate accounts for 10% of all diseases, disability rate 50%-70%, and its midbrain infarction, namely cerebral infarction is the modal type of apoplexy.Paralytic is after hospital's treatment is survived, often leave over the obstacles such as some motions, sensation and language, after leaving hospital, family care treatment is a kind of effective good method, now, family members are if accomplish that nursing is appropriate, just can eliminate or alleviate the functional defect of patient, the disability rate of apoplexy can be reduced, disable degree, improve patient's daily life active ability.
Current topmost rehabilitation maneuver has massage suffering limb, passive exercise, active exercise, activity of daily living training etc., is aided with acupuncture, medicine foam washing, psychological counseling etc.More and more adopted oral traditional Chinese medicine preparation to carry out auxiliary treatment in recent years, and reached QI and blood regulating, relief of symptoms, promote human body recovery from illness, reduce the object of sequela.At present, the Chinese patent medicine being used for the treatment of apoplexy and sequela also existing all is in various degree taken effect slow, the defect such as curative effect is remarkable not, haves much room for improvement.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of apoplexy recovering aid scheme, comprises medicine, preparation method and application thereof.
For solving the problems of the technologies described above, Chinese medicine composition for apoplexy recovering aid of the present invention, raw material composition and the parts by weight of making described Effective Component of Chinese Medicine are, Cortex Phellodendri 2-10 part, Rhizoma Atractylodis 5-8 part, Rhizoma Smilacis Glabrae 7-20 part, Herba Plantaginis 4-9 part, Rhizoma Alismatis 3-10 part, Herba Taraxaci 5-12 part, Flos Lonicerae 6-10 part, Radix Isatidis 3-14 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-20 part, Fructus Forsythiae 4-20 part, Radix Ophiopogonis 6-8 part, Fructus Gardeniae 3-6 part, Endothelium Corneum Gigeriae Galli 2-7 part, Fructus Rosae Laevigatae 8-10 part, Rhizoma Polygonati Odorati 2-5 part, Carapax et Plastrum Testudinis 7-10 part, Fructus Alpiniae Oxyphyllae 3-6 part, Radix Clematidis 1-8 part, Semen Cassiae 4-7 part, Herba clerodendranthi spicati 3-6 part, Herba Schizonepetae 4-9 part, Fel Serpentis 10-20 part.
Preferably, the weight portion of each raw material is, Cortex Phellodendri 6 parts, Rhizoma Atractylodis 7 parts, Rhizoma Smilacis Glabrae 12 parts, Herba Plantaginis 6 parts, Rhizoma Alismatis 5 parts, Herba Taraxaci 10 parts, Flos Lonicerae 7 parts, Radix Isatidis 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 12 parts, Fructus Forsythiae 15 parts, Radix Ophiopogonis 6 parts, Fructus Gardeniae 5 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Rosae Laevigatae 9 parts, Rhizoma Polygonati Odorati 4 parts, Carapax et Plastrum Testudinis 8 parts, Fructus Alpiniae Oxyphyllae 4 parts, Radix Clematidis 2 parts, Semen Cassiae 4 parts, Herba clerodendranthi spicati 5 parts, Herba Schizonepetae 5 parts, Fel Serpentis 10 parts.
Preferably, described Chinese medicine composition is the one in tablet, capsule, pill, granule or oral liquid.
The invention still further relates to the preparation method of the above-mentioned Chinese medicine composition for apoplexy recovering aid, comprise the following steps,
A. Cortex Phellodendri 2-10 part is got, Rhizoma Atractylodis 5-8 part, Rhizoma Smilacis Glabrae 7-20 part, Herba Plantaginis 4-9 part, Rhizoma Alismatis 3-10 part, Herba Taraxaci 5-12 part, Flos Lonicerae 6-10 part, is cut into small pieces, and adds the soak by water of 10-15 times of raw material weight, after water boils, slow fire boils 2-3 hour, staticly settles 12-24 hour, filters, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtain dry extract block A, for subsequent use;
B. Radix Isatidis 3-14 part is got, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-20 part, Fructus Forsythiae 4-20 part, Radix Ophiopogonis 6-8 part, Fructus Gardeniae 3-6 part, Endothelium Corneum Gigeriae Galli 2-7 part, Fructus Rosae Laevigatae 8-10 part, Rhizoma Polygonati Odorati 2-5 part, Carapax et Plastrum Testudinis 7-10 part, Fructus Alpiniae Oxyphyllae 3-6 part, Radix Clematidis 1-8 part, Semen Cassiae 4-7 part, pulverize, add 4-7 times of quality, mass percent concentration is 60%-70% ethanol, reflux, extract, 20-40 minute, by extracting liquid filtering, filtrate concentrate drying is become dry extract block B, for subsequent use;
C. get Herba clerodendranthi spicati 3-6 part, Herba Schizonepetae 4-9 part, is cut into small pieces, 20 minutes are cured at 100 degrees Celsius-150 degrees Celsius, fine gtinding after pulverizing, crosses 200 mesh sieves, adds 2 ~ 3 times to the white vinegar of medicated powder weight, soak 5 days, by said mixture concentrate drying, fine gtinding, crosses 800 mesh sieves, obtain powder C, for subsequent use;
D. get Fel Serpentis 10-20 part, add the distilled water of 1 times of quality, stirring is smashed, and stirs evenly, then adds 1 times of quality dehydrated alcohol, stirs, and by extracting liquid filtering, filtrate is carried out evacuation drying in 3 hours, reaches vacuum and be less than 50Pa, obtain Fel Serpentis powder;
E. dry extract block A and dry extract block B is ground into powder, adds the Fel Serpentis powder made and stir evenly, cross 500 mesh sieves, then add powder C, mixing, obtains the drug powder for apoplexy recovering aid.
The invention still further relates to the tablet made by the drug powder made according to the method described above, the Sodium Hydroxymethyl Stalcs tabletting that the medicine of described tablet made by 15 mass parts adds the starch of 1 mass parts, the hydroxypropyl emthylcellulose of 1 mass parts and 1 mass parts forms.
Improve as one, tableting processes comprises the precompressed before main pressure and main pressure, and wherein precompression is 6-10KN, and dry 2 minutes at the temperature of 50 degrees Celsius-60 degrees Celsius tabletting after precompressed, then carry out main pressure, principal pressure is 50-70KN.
The invention still further relates to the capsule made with the drug powder that said method is made, described capsule is enteric coated capsule.
The invention still further relates to the application of said medicine in preparation apoplexy recovering aid medicine.
Cortex Phellodendri has heat clearing and damp drying, and pathogenic fire purging is except steaming, and the effect of detoxification sore treatment, is used for the treatment of hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency; Rhizoma Atractylodis cure mainly drying damp and strengthening spleen, head heavy sensation of the body pain, arthromyodynia warm nature, podomere is ached, can wind-damp dispelling, improving eyesight; Rhizoma Smilacis Glabrae detoxifies, dehumidifying, easing joint movement; Herba Plantaginis can remove pathogenic wind toxic, the liver affected by pathogenic wind heat, malicious wind dotting punch order, and swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart; Rhizoma Alismatis has foster the five internal organs, physical strength profiting, plays cloudy gas, the merit of tonifying deficiency; Herba Taraxaci function heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Flos Lonicerae cures mainly disease under distension, epidemic febrile disease heating, pyretic toxicity carbuncle and ulcer; Radix Isatidis has effect of heat-clearing and toxic substances removing, is used for the treatment of temperature poison; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) energy relaxing muscles and tendons and activating QI and blood in the collateral, circulation of qi promoting damp eliminating, cold expelling dispels the wind, eliminating dampness to stop diarrhea; The heat clearing away of Fructus Forsythiae energy, removing toxic substances, eliminating stagnation, detumescence; Radix Ophiopogonis nourishing YIN and moistening the lung reinforcing stomach reg fluid clears away heart-fire relieving restlessness; Fructus Gardeniae heat clearing away, pathogenic fire purging, removing heat from blood, controls calentura restlessness of asrhenia type and insomnia; Endothelium Corneum Gigeriae Galli removing food stagnancy is stagnant, strengthening the spleen and stomach; Fructus Rosae Laevigatae controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents; Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, Zhi Yangming epidemic febrile disease, lower rear antiperspirant goes out; Carapax et Plastrum Testudinis nourishing kidney YANG hyperactivity suppressing, replenishing kidney and strengthening bone, reinforcing the heart of nourishing blood; Fructus Alpiniae Oxyphyllae warming the spleen, warming the kidney, solid and gas; Radix Clematidis expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, for rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx; Semen Cassiae liver heat removing and eyesight improving, loosening bowel to relieve constipation, controls the many tear of photophobia, has a headache dizzy, poor vision; Herba clerodendranthi spicati has more antibacterial, antiinflammation, renal tubules can be made to destroy alleviate, messangial cell structural lesions reduces, complete glomerule number increases, protection and improvement result is had to the damage of nephridial tissue, glomerular filtration and kidney circulation volume can be increased, promote the eliminating of toxic metabolite, reduce blood uric acid in body; The main cold and heat of Herba Schizonepetae, scrofula, the raw skin ulcer of scrofula, broken knot gather qi together, lower blood stasis, except arthralgia chiefly caused by damp pathogen; Fel Serpentis has expelling wind and removing dampness, refrigerant improving eyesight, detoxifies and go effect of miliaria; The nervous system of adjustable benefit people, hormonal system and immune system, delay body aging.
Full side plays altogether and tonifies Qi of the kidney, tendons relaxing and meridians dredging, promotes nerve repair function, is used for the treatment of the functional disorder disease that Cranial nerve injury as birth trauma that apoplexy causes causes.Medicine goes directly disease institute, and play a role fast, few side effects, has powerful promoting blood circulation to remove obstruction in the collateral effect, can improve perineural blood circulation and body fluid circulatory fast, improve the blood circulation of nervus centralis, contribute to rehabilitation.Modern pharmacology also confirms that more than Chinese medicine has to be improved blood circulation, diminishes inflammation, regulatory enzyme change in organization, reduce Endothelin, reduce neuronal cell death and apoptosis, raising neurotrophic factor content, suppress the effects such as excitatory amino acid cytotoxicity, the microcirculatory blood flow around pathological changes cranial nerve can be made to increase, capillary open increased number, improves ischemic hypoxia state; Wherein the effect such as antiinflammatory, anti-stress, enhancing immunologic function then can suppress the inflammatory of local to change, and alleviates edema, alleviates neural pressurized situation, and improve the pathological change of cranial nerve, promote neurological functional recovery.In therapeutic process, Chinese medicine has taking convenience, cheap, and the advantage such as have no adverse reaction, and clinic is promoted.
Clinical efficacy is summed up
One, the physical data of subjects
According to the disease of tcm Standardization of diagnosis and curative effect that State Administration of Traditional Chinese Medicine announces, carry out Selecting research object, adopts pharmaceutical composition of the present invention to treat standard compliant 208 routine patients altogether, wherein man 106 example, female 102 is routine, the age be 44-68 year, 56.7 years old mean age.
Patient is divided into treatment group and matched group two groups at random, treatment group 104 example, wherein male 53 example, women 51 example, 56.2 years old mean age, matched group 104 example, wherein male 53 example, women 51 example, 57.2 years old mean age.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, two groups of patient's same degree all participated in massage suffering limb, passive exercise, active exercise, activity of daily living training etc., without significant difference, there is comparability.
Two, medicament selection
Treatment group uses the drug powder treatment prepared by embodiment 2, oral, capsule one time 2, tablet two panels, and 3 times on the one, warm water delivery service after meal 15 days is a course for the treatment of, treats 6 courses for the treatment of altogether.Matched group takes placebo.
Three, efficacy determination
Treat evaluation criteria as follows with reference to the diagnoses and treatment standard formulation of State Administration of Traditional Chinese Medicine, daily life active ability is divided into good, in, differ from three grades:
Good: to have slight dysfunction, the daily routines of energy complete independently part, need part to help;
In: there is moderate dysfunction, need to help greatly to complete activities of daily living;
Difference: have severe dysfunction, most of activities of daily living can not complete or need other people to attend.
Four, clinical observation result
After the treatment of 6 courses for the treatment of, the clinical observation on the therapeutic effect result of the test of traditional Chinese medicine composition for treating apoplexy of the present invention
Number of cases Good In Difference
Treatment group 104 51 28 25
Matched group 104 32 35 37
Clinical observation on the therapeutic effect result shows, two groups of patients are in the indiscriminate situation of other treatment condition, and the therapeutic effect for the treatment of group significantly will be better than the therapeutic effect of matched group; Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Through this medicine of long-term taking, the patient of 90% can recover walking, and the patient limb function of 24% is recovered substantially, and 30% resumes work; And matched group 75% recovers walking, the patient limb function of 15% is recovered substantially, and 20% resumes work.Contrast recovery extent same patient in two groups, the convalescent period of taking the patient of this medicine obviously shortens.
Detailed description of the invention
Embodiment 1
Chinese medicine composition for apoplexy recovering aid of the present invention, make described Effective Component of Chinese Medicine raw material composition and parts by weight be, Cortex Phellodendri 2 parts, Rhizoma Atractylodis 6 parts, Rhizoma Smilacis Glabrae 13 parts, Herba Plantaginis 5 parts, Rhizoma Alismatis 3 parts, Herba Taraxaci 5 parts, Flos Lonicerae 10 parts, Radix Isatidis 3 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 15 parts, Fructus Forsythiae 10 parts, Radix Ophiopogonis 7 parts, Fructus Gardeniae 4 parts, Endothelium Corneum Gigeriae Galli 2 parts, Fructus Rosae Laevigatae 8 parts, Rhizoma Polygonati Odorati 4 parts, Carapax et Plastrum Testudinis 8 parts, Fructus Alpiniae Oxyphyllae 7 parts, Radix Clematidis 4 parts, Semen Cassiae 4 parts, Herba clerodendranthi spicati 6 parts, Herba Schizonepetae 5 parts, Fel Serpentis 15 parts.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps,
A. Cortex Phellodendri 2 parts is got, Rhizoma Atractylodis 6 parts, Rhizoma Smilacis Glabrae 13 parts, Herba Plantaginis 5 parts, Rhizoma Alismatis 3 parts, Herba Taraxaci 5 parts, Flos Lonicerae 10 parts, carries out drying by above-mentioned medical material, is cut into small pieces, add the soak by water of 10-15 times of raw material weight, after water boils, slow fire boils 2-3 hour, staticly settles 12 hours, filter, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A, for subsequent use;
B. Radix Isatidis 3 parts is got, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 15 parts, Fructus Forsythiae 10 parts, Radix Ophiopogonis 7 parts, Fructus Gardeniae 4 parts, Endothelium Corneum Gigeriae Galli 2 parts, Fructus Rosae Laevigatae 8 parts, Rhizoma Polygonati Odorati 4 parts, Carapax et Plastrum Testudinis 8 parts, Fructus Alpiniae Oxyphyllae 7 parts, Radix Clematidis 4 parts, Semen Cassiae 4 parts, carries out drying by above-mentioned medical material, pulverize, add 4-7 times of quality, mass percent concentration is 60%-70% ethanol, reflux, extract, 20-40 minute, by extracting liquid filtering, filtrate concentrate drying is become dry extract block B, for subsequent use;
C. get Herba clerodendranthi spicati 6 parts, Herba Schizonepetae 5 parts, is cut into small pieces, 20 minutes are cured at 100 degrees Celsius-150 degrees Celsius, fine gtinding after pulverizing, crosses 200 mesh sieves, adds 2 ~ 3 times to the white vinegar of medicated powder weight, soak 5 days, by said mixture concentrate drying, fine gtinding, crosses 800 mesh sieves, obtain powder C, for subsequent use;
D. get Fel Serpentis 15 parts, add the distilled water of 1 times of quality, stirring is smashed, and stirs evenly, then adds 1 times of quality dehydrated alcohol, stirs, and by extracting liquid filtering, filtrate is carried out evacuation drying in 3 hours, reaches vacuum and be less than 50Pa, obtain Fel Serpentis powder;
E. dry extract block A and dry extract block B is ground into powder, adds the Fel Serpentis powder made and stir evenly, cross 500 mesh sieves, then add powder C, mixing, obtains the drug powder for apoplexy recovering aid.
Embodiment 2
Chinese medicine composition for apoplexy recovering aid of the present invention, make described Effective Component of Chinese Medicine raw material composition and parts by weight be, Cortex Phellodendri 6 parts, Rhizoma Atractylodis 7 parts, Rhizoma Smilacis Glabrae 12 parts, Herba Plantaginis 6 parts, Rhizoma Alismatis 5 parts, Herba Taraxaci 10 parts, Flos Lonicerae 7 parts, Radix Isatidis 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 12 parts, Fructus Forsythiae 15 parts, Radix Ophiopogonis 6 parts, Fructus Gardeniae 5 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Rosae Laevigatae 9 parts, Rhizoma Polygonati Odorati 4 parts, Carapax et Plastrum Testudinis 8 parts, Fructus Alpiniae Oxyphyllae 4 parts, Radix Clematidis 2 parts, Semen Cassiae 4 parts, Herba clerodendranthi spicati 5 parts, Herba Schizonepetae 5 parts, Fel Serpentis 10 parts.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps,
A. Cortex Phellodendri 6 parts is got, Rhizoma Atractylodis 7 parts, Rhizoma Smilacis Glabrae 12 parts, Herba Plantaginis 6 parts, Rhizoma Alismatis 5 parts, Herba Taraxaci 10 parts, Flos Lonicerae 7 parts, carries out drying by above-mentioned medical material, is cut into small pieces, add the soak by water of 10-15 times of raw material weight, after water boils, slow fire boils 2-3 hour, staticly settles 12-24 hour, filter, concentrated filtrate obtains clear paste, by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtains dry extract block A, for subsequent use;
B. Radix Isatidis 10 parts is got, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 12 parts, Fructus Forsythiae 15 parts, Radix Ophiopogonis 6 parts, Fructus Gardeniae 5 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Rosae Laevigatae 9 parts, Rhizoma Polygonati Odorati 4 parts, Carapax et Plastrum Testudinis 8 parts, Fructus Alpiniae Oxyphyllae 4 parts, Radix Clematidis 2 parts, Semen Cassiae 4 parts, carries out drying by above-mentioned medical material, pulverize, add 4-7 times of quality, mass percent concentration is 60%-70% ethanol, reflux, extract, 20-40 minute, by extracting liquid filtering, filtrate concentrate drying is become dry extract block B, for subsequent use;
C. get Herba clerodendranthi spicati 5 parts, Herba Schizonepetae 5 parts, is cut into small pieces, 20 minutes are cured at 100 degrees Celsius-150 degrees Celsius, fine gtinding after pulverizing, crosses 200 mesh sieves, adds 2 ~ 3 times to the white vinegar of medicated powder weight, soak 5 days, by said mixture concentrate drying, fine gtinding, crosses 800 mesh sieves, obtain powder C, for subsequent use;
D. get Fel Serpentis 10 parts, add the distilled water of 1 times of quality, stirring is smashed, and stirs evenly, then adds 1 times of quality dehydrated alcohol, stirs, and by extracting liquid filtering, filtrate is carried out evacuation drying in 3 hours, reaches vacuum and be less than 50Pa, obtain Fel Serpentis powder;
E. dry extract block A and dry extract block B is ground into powder, adds the Fel Serpentis powder made and stir evenly, cross 500 mesh sieves, then add powder C, mixing, obtains the drug powder for apoplexy recovering aid.
The invention still further relates to the tablet made by the drug powder made according to the method described above, the medicine got made by 15 mass parts adds the Sodium Hydroxymethyl Stalcs of the starch of 1 mass parts, the hydroxypropyl emthylcellulose of 1 mass parts and 1 mass parts, tabletting after mixing.Tableting processes is divided into two steps, comprises the precompressed before main pressure and main pressure, first carries out precompressed with the pressure of 6-10KN, and after molding, tabletting is dried 2 minutes at the temperature of 50 degrees Celsius-60 degrees Celsius, then carries out main pressure, and principal pressure is 50-70KN.The tablet adopting this tabletting processing mode to suppress can be that the hardness of tablet is moderate, is conducive to discharging air in powder, and reduce sliver, obtained flap-type outward appearance is good.In view of the complicated component of this medicine, the drying operation in the middle of twice tabletting, can make the humidity of tablet reduce, and increases the shelf-life of tablet.
The capsule that the drug powder that said method obtains also is made.Find through test, the gastric solubility preparation effect of this medicine is not as enteric coated preparation, and reason may be effective ingredient easy degeneration under the effect of hydrochloric acid of medicine, and gastric acid damages active component.Therefore the enteric coated capsule adopted need possess not disintegrate in 2 hours in the hydrochloric acid solution of 0.1mol/L, PH=1, and the effect of whole stripping within 40 minutes in small intestinal.
Model case is illustrated
1. Lee so-and-so, female, 61 years old, people from Jiaozhou City of Shandong Province, there is dysphagia suddenly in patient, right side limb activity is ineffective, can not stand alone, walk, companion's slurred speech, no headache, vomiting, the symptom such as to can't take care of oneself.The colleague carrying out rehabilitation takes this medicine, and through two courses for the treatment of, status of patient has had and is clearly better, and after five courses for the treatment of, patient can walk, and in slight hemiplegic gait, lamprophonia, life is taken care of oneself completely.
2. Zhang, man, 52 years old, people from Jiaozhou City of Shandong Province.Left half cool skin of patient, imperception, gatism, inarticulateness of speaking, cannot walk.The colleague carrying out rehabilitation takes this medicine, and through two courses for the treatment of, the left half body of patient starts there is consciousness, after three courses for the treatment of of taking medicine, left half body body temperature is normal, and defecation not incontinence, can walk about when there being support, take medicine after 6 courses for the treatment of, can walk about voluntarily, life can be taken care of oneself substantially.
3. Hu, man, 65 years old, people from Jimo City of Shandong Province, the paralysis for the treatment of front right half body, from face until foot does not have consciousness, can not have a meal, can not speak, after taking medicine three days, right half body has worm to climb sensation, start to regain consciousness, after two weeks of taking medicine, right half body can move, and can have a meal; After taking medicine one month, can sit up; Taking medicine can leave the bed after two months walks about, and hands can take thing, and life can be taken care of oneself substantially.After adhere to taking medicine, application returns to one's perfect health, and can do housework.
4. gold, female, 55 years old, people from Zhucheng, Shandong Province, before treatment, left hand can not take thing, and left foot can not lifted on foot, walks unstable.After taking medicine one month, left hand can pick up large piece article, and fine movement is slightly inconvenient, and left foot can lift; After taking medicine two months, left hand can do fine movement, and basic recovery of walking normally, can normally work.

Claims (8)

1. the Chinese medicine composition for apoplexy recovering aid, it is characterized in that: raw material composition and the parts by weight of making described Effective Component of Chinese Medicine are, Cortex Phellodendri 2-10 part, Rhizoma Atractylodis 5-8 part, Rhizoma Smilacis Glabrae 7-20 part, Herba Plantaginis 4-9 part, Rhizoma Alismatis 3-10 part, Herba Taraxaci 5-12 part, Flos Lonicerae 6-10 part, Radix Isatidis 3-14 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-20 part, Fructus Forsythiae 4-20 part, Radix Ophiopogonis 6-8 part, Fructus Gardeniae 3-6 part, Endothelium Corneum Gigeriae Galli 2-7 part, Fructus Rosae Laevigatae 8-10 part, Rhizoma Polygonati Odorati 2-5 part, Carapax et Plastrum Testudinis 7-10 part, Fructus Alpiniae Oxyphyllae 3-6 part, Radix Clematidis 1-8 part, Semen Cassiae 4-7 part, Herba clerodendranthi spicati 3-6 part, Herba Schizonepetae 4-9 part, Fel Serpentis 10-20 part.
2. according to the Chinese medicine composition for apoplexy recovering aid according to claim 1, it is characterized in that: the weight portion of each raw material is, Cortex Phellodendri 6 parts, Rhizoma Atractylodis 7 parts, Rhizoma Smilacis Glabrae 12 parts, Herba Plantaginis 6 parts, Rhizoma Alismatis 5 parts, Herba Taraxaci 10 parts, Flos Lonicerae 7 parts, Radix Isatidis 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 12 parts, Fructus Forsythiae 15 parts, Radix Ophiopogonis 6 parts, Fructus Gardeniae 5 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Rosae Laevigatae 9 parts, Rhizoma Polygonati Odorati 4 parts, Carapax et Plastrum Testudinis 8 parts, Fructus Alpiniae Oxyphyllae 4 parts, Radix Clematidis 2 parts, Semen Cassiae 4 parts, Herba clerodendranthi spicati 5 parts, Herba Schizonepetae 5 parts, Fel Serpentis 10 parts.
3. according to the Chinese medicine composition for apoplexy recovering aid in claim 2 described in any one, it is characterized in that: described Chinese medicine composition is the one in tablet, capsule, pill, granule or oral liquid.
4. prepare a method for the Chinese medicine composition for apoplexy recovering aid described in claim 1, it is characterized in that: comprise the following steps,
A. Cortex Phellodendri 2-10 part is got, Rhizoma Atractylodis 5-8 part, Rhizoma Smilacis Glabrae 7-20 part, Herba Plantaginis 4-9 part, Rhizoma Alismatis 3-10 part, Herba Taraxaci 5-12 part, Flos Lonicerae 6-10 part, is cut into small pieces, and adds the soak by water of 10-15 times of raw material weight, after water boils, slow fire boils 2-3 hour, staticly settles 12-24 hour, filters, concentrated filtrate obtains clear paste, and by gained clear paste at the temperature of 45 DEG C-55 DEG C, decompressed microwave is dry, obtain dry extract block A, for subsequent use;
B. Radix Isatidis 3-14 part is got, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10-20 part, Fructus Forsythiae 4-20 part, Radix Ophiopogonis 6-8 part, Fructus Gardeniae 3-6 part, Endothelium Corneum Gigeriae Galli 2-7 part, Fructus Rosae Laevigatae 8-10 part, Rhizoma Polygonati Odorati 2-5 part, Carapax et Plastrum Testudinis 7-10 part, Fructus Alpiniae Oxyphyllae 3-6 part, Radix Clematidis 1-8 part, Semen Cassiae 4-7 part, pulverize, add 4-7 times of quality, mass percent concentration is 60%-70% ethanol, reflux, extract, 20-40 minute, by extracting liquid filtering, filtrate concentrate drying is become dry extract block B, for subsequent use;
C. get Herba clerodendranthi spicati 3-6 part, Herba Schizonepetae 4-9 part, is cut into small pieces, 20 minutes are cured at 100 degrees Celsius-150 degrees Celsius, fine gtinding after pulverizing, crosses 200 mesh sieves, adds 2 ~ 3 times to the white vinegar of medicated powder weight, soak 5 days, by said mixture concentrate drying, fine gtinding, crosses 800 mesh sieves, obtain powder C, for subsequent use;
D. get Fel Serpentis 10-20 part, add the distilled water of 1 times of quality, stirring is smashed, and stirs evenly, then adds 1 times of quality dehydrated alcohol, stirs, and by extracting liquid filtering, filtrate is carried out evacuation drying in 3 hours, reaches vacuum and be less than 50Pa, obtain Fel Serpentis powder;
E. dry extract block A and dry extract block B is ground into powder, adds the Fel Serpentis powder made and stir evenly, cross 500 mesh sieves, then add powder C, mixing, obtains the drug powder for apoplexy recovering aid.
5. with the tablet that the medicine that method in claim 4 is made is made, it is characterized in that: the Sodium Hydroxymethyl Stalcs tabletting that the medicine of described tablet made by 15 mass parts adds the starch of 1 mass parts, the hydroxypropyl emthylcellulose of 1 mass parts and 1 mass parts forms.
6. prepare the method for tablet described in claim 5 for one kind, it is characterized in that: tableting processes comprises the precompressed before main pressure and main pressure, and wherein precompression is 6-10KN, after precompressed, tabletting is dried 2 minutes at the temperature of 50 degrees Celsius-60 degrees Celsius, carry out main pressure again, principal pressure is 50-70KN.
7. with the capsule that the medicine that method in claim 4 is made is made, it is characterized in that: described capsule is enteric coated capsule.
8. the application of the arbitrary pharmaceutical composition described in claim 1 ~ 7 in preparation apoplexy recovering aid medicine.
CN201510063034.XA 2015-02-08 2015-02-08 Traditional Chinese medicine composition for assisted rehabilitation of stroke and preparation method of composition Pending CN104524397A (en)

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CN105535454A (en) * 2015-12-29 2016-05-04 张林涛 Medicine for treating diastolic cardiac dysfunction
CN106215051A (en) * 2016-08-31 2016-12-14 王东宝 A kind of Chinese and Western compound medicine treating peripheral nerve injury and preparation method

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CN105535454A (en) * 2015-12-29 2016-05-04 张林涛 Medicine for treating diastolic cardiac dysfunction
CN106215051A (en) * 2016-08-31 2016-12-14 王东宝 A kind of Chinese and Western compound medicine treating peripheral nerve injury and preparation method

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