CN106215051A - A kind of Chinese and Western compound medicine treating peripheral nerve injury and preparation method - Google Patents
A kind of Chinese and Western compound medicine treating peripheral nerve injury and preparation method Download PDFInfo
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- CN106215051A CN106215051A CN201610770944.6A CN201610770944A CN106215051A CN 106215051 A CN106215051 A CN 106215051A CN 201610770944 A CN201610770944 A CN 201610770944A CN 106215051 A CN106215051 A CN 106215051A
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Abstract
The invention discloses a kind of Chinese and Western compound medicine treating peripheral nerve injury and preparation method, belong to pharmaceutical technology field；The raw material of ingredient of the present invention consists of: Caulis fici pumilae (Fructus Fici Pumilae), Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae, Herba Lycopodii Obscuri, Radix fici panduratae, Herba speranskiae cantonensis, Radix et Rhizoma Smilacis Ripariae, Radix Ligustici Brachylobi, Radix anthrisci, Radix Dipsaci, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Semen Nelumbinis, Fructus Rosae Laevigatae, profenamine, carbamazepine and Zaleplon；Medicine of the present invention uses the Therapeutic Method of the combinat ion of Traditional Chinese Medicine and Pharmacy with Western Pharmacy to use Chinese medicine, western medicine better than the most simple, there is expelling wind and removing dampness, strong muscles and bones, promoting blood circulation and stopping pain, the effect of channels sootheing and network vessel quickening, can be with the raising Chinese medicine ingredients of maximal efficiency and Western medicine effect, play complementary and castering action, improve medicinal effects, can blood circulation promoting, improve numb limbs and tense tendons, the myalgia that causes peripheral nerve injury, paraesthesia, the symptom such as the dyskinesia have good therapeutic effect, can quickly repair nerve, promote neurological functional recovery.
Description
Art
The present invention relates to pharmaceutical technology field, particularly relate to a kind of Chinese and Western compound medicine treating peripheral nerve injury and system
Preparation Method.
Background technology
Peripheral nerve refers to the nerve beyond nervus centralis (brain and spinal cord), and peripheral nerve injury is to be caused by a variety of causes
The region making this innervation sensory disturbance, the dyskinesia and malnutrition occur, the damage of stretch injury, firearm, repressive
Damage, ischemia injury, drug injection damage and other iatrogenic injury all can cause peripheral nerve injury.
The clinical manifestation of peripheral nerve injury is:
1. brachia plexus injury.Mainly show as whole upper limb sagging, adduction of the upper limb, it is impossible to abduction outward turning, receive in forearm
Stretching, it is impossible to supination or bending before rotation, have a long and narrow sensory disturbance district outside omoplate, upper arm and forearm, the little muscle of hand is complete
Portion's atrophy and in claw type, hand ulnar side and inner forearm are felt disappearance.
2. axillary nerve injury.Mainly showing as the dyskinesia, shoulder abduction amplitude reduces, skin of deltoid region sensation barrier
Hindering, triangular muscle amyotrophy, shoulder loses the outward appearance of rounded protuberance, and acromion highlights, and is formed " square shoulder ".
3. musculocutaneous nerve injury.Musculocutaneous nerve, after lateral cord sends, tiltedly wears coracobrachialis, between biceps brachii m. and brachialis
Descending, and send branch and arrange above-mentioned three fleshes, eventually in elbow joint outside just above, pass arm deep fascia.
4. median nerve injury.First, second and third refers to flexing defunctionalization, and thumb opposition is lost, muscle of thenar atrophy,
Ape palm deformity, forefinger, middle finger minor details anesthesia occur.
5. radial nerve injury.Mainly showing as stretching wrist power to disappear, thumb abduction and extensor digitorum's power disappear, and the back of the hand first and second is slapped
Feel between bone to be wholly absent.
6. injury of radial nerve.4th and the minor details of the five fingers the most flexible, interosseus is paralysed, and receives the funeral of abduction function in finger
Losing, hypothenar atrophy flattens, and little finger of toe is felt to be wholly absent.
7. femoral nerve injury.The dyskinesia, muscle group paralysis before stock, lift lower limb difficulty during walking, it is impossible to stretch shank；Sensation barrier
Hindering, before stock and facies medialis cruris esthesiodermia, atrophy of quadriceps femoris, patella highlights.
8. injury of sciatic nerve.Biceps femoris is often benumbed, and semitendinosus m. and semimembranosus m. are seldom got involved, and shank or vola are normal
With jumping pain, fiber crops pain or causalgia sense.
9. common peroneal nerve injury.Intersection point deformity, foot and toe can not dorsiflexion, can not abduction turn up, before instep and little toe outside
Side sensory deprivation.
At present, the treatment of peripheral nerve injury remains one of clinical problem, and Drug therapy is peripheral nerve injury repaiies
Multiple important measures, have use western medicine, but side effect are huge in clinic, although Chinese medicine is taken on heavy responsibilities in this field always,
Clinical effectiveness but and inconspicuous, takes effect very slow, and patient is difficult to adhere to, therefore combines tcm therapy and western medicine therapy works out one
The inexpensive drugs that can promote neural fast-growth, can guarantee that again regenerated nervous fibers function is necessary.
Summary of the invention
The invention provides a kind of Chinese and Western compound medicine treating peripheral nerve injury and preparation method, medicine of the present invention is adopted
More better than the most simple Chinese medicine, western medicine with the Therapeutic Method of the combinat ion of Traditional Chinese Medicine and Pharmacy with Western Pharmacy, there is expelling wind and removing dampness, strong
Muscles and bones, promoting blood circulation and stopping pain, the effect of channels sootheing and network vessel quickening, can with the raising Chinese medicine ingredients of maximal efficiency and Western medicine effect, play complementary and
Castering action, improves medicinal effects, it is possible to blood circulation promoting, improves numb limbs and tense tendons, the muscle causing peripheral nerve injury
The symptoms such as pain, paraesthesia, the dyskinesia have good therapeutic effect, can quickly repair nerve, promote function of nervous system
Recover.
For achieving the above object, technical scheme is implemented as follows:
A kind of Chinese and Western compound medicine treating peripheral nerve injury, described medicine is made up of Chinese medicine and western medicine composition, makes
The raw material of described Chinese medicine ingredients forms and parts by weight are: Caulis fici pumilae (Fructus Fici Pumilae) 51～81 parts, Cortex Seu Folium Actinodaphnes Pilosae 48～78 parts, Foliumet Ramulus Evodiae 46～76
Part, Herba Lycopodii Obscuri 44～74 parts, Radix fici panduratae 41～71 parts, Herba speranskiae cantonensis 36～66 parts, Radix et Rhizoma Smilacis Ripariae 33～63 parts, Radix Ligustici Brachylobi 31～61 parts,
Radix anthrisci 29～59 parts, Radix Dipsaci 26～56 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 24～54 parts, Semen Nelumbinis 22～52 parts, Fructus Rosae Laevigatae 21～51 parts；Make described
The raw material of western medicine composition forms and parts by weight are: profenamine 0.6～1.5 parts, carbamazepine 0.3～1.3 parts, Zaleplon
0.1～1.2 part.
Described medicine is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be:
Caulis fici pumilae (Fructus Fici Pumilae) 74 parts, 71 parts of Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae 69 parts, Herba Lycopodii Obscuri 67 parts, Radix fici panduratae 64 parts, Herba speranskiae cantonensis 59 parts, Radix et Rhizoma Smilacis Ripariae 57 parts, river is prevented
Wind 55 parts, Radix anthrisci 53 parts, Radix Dipsaci 49 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 47 parts, 45 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 44 parts；Make the former of described western medicine composition
Material forms and parts by weight are: profenamine 1.1 parts, carbamazepine 0.8 part, Zaleplon 0.8 part.
Described medicine is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be:
Caulis fici pumilae (Fructus Fici Pumilae) 67 parts, 64 parts of Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae 62 parts, Herba Lycopodii Obscuri 60 parts, Radix fici panduratae 57 parts, Herba speranskiae cantonensis 52 parts, Radix et Rhizoma Smilacis Ripariae 50 parts, river is prevented
Wind 47 parts, Radix anthrisci 46 parts, Radix Dipsaci 42 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 40 parts, 38 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 37 parts；Make the former of described western medicine composition
Material forms and parts by weight are: profenamine 0.9 part, carbamazepine 0.6 part, Zaleplon 0.5 part.
Described medicine is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be:
Caulis fici pumilae (Fructus Fici Pumilae) 59 parts, 55 parts of Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae 54 parts, Herba Lycopodii Obscuri 53 parts, Radix fici panduratae 49 parts, Herba speranskiae cantonensis 44 parts, Radix et Rhizoma Smilacis Ripariae 41 parts, river is prevented
Wind 40 parts, Radix anthrisci 35 parts, Radix Dipsaci 34 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 33 parts, 30 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 29 parts；Make the former of described western medicine composition
Material forms and parts by weight are: profenamine 0.7 part, carbamazepine 0.4 part, Zaleplon 0.3 part.
The preparation method of a kind of Chinese and Western compound medicine treating peripheral nerve injury, comprises the following steps that:
(1) Caulis fici pumilae (Fructus Fici Pumilae), Cortex Seu Folium Actinodaphnes Pilosae, Herba Lycopodii Obscuri, Herba speranskiae cantonensis and Semen Nelumbinis are placed in container, add relative mixture quality 6～8 times
Amount distilled water immersion 2～after 3 days, add 3～4 times amount mass concentration be 45%～55% ethanol, be heated to reflux 4 hours,
Filter, obtain extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, are heated to reflux 2
Hour；Filter, obtain extracting solution；Merge twice extracting solution, filter, obtain filtrate, be cooled to room temperature, be concentrated into water content be 30%～
The extractum of 40%, standby；
(2) Foliumet Ramulus Evodiae, Radix Ligustici Brachylobi and Radix Dipsaci being cleaned, immersion runs through, and takes out section, and the saline spraying equimultiple is mixed thoroughly,
Slow fire fried dry, taking-up is dried in the air cool, is ground into powder, obtained the fine powder of 200 mesh in being placed in mortar, standby；
(3) Radix fici panduratae and Radix et Rhizoma Smilacis Ripariae are cleaned, juice of squeezing out in being placed in juice extractor, cold preservation 4 hours, filter, remove impurity
With precipitate, carry out desolventing technology through activated carbon adsorption, be concentrated into the extractum that water content is 30%～40%, standby；
(4) Radix anthrisci and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) are shredded, dry, sieve dedusting bits, grind into powder in being placed in mortar, obtained the fine powder of 160 mesh,
Standby；
(5) Fructus Rosae Laevigatae is slightly soaked, run through, rip cutting two lobe, remove hair, core, be placed at 200 DEG C～220 DEG C drying, taking-up is dried in the air
Cool, grind into powder in being placed in mortar, obtained the fine powder of 180 mesh, standby；
(6) grind into powder in profenamine, carbamazepine and Zaleplon being placed in mortar, obtained the fine powder of 220 mesh, standby
With；
(7) by step (1), extractum and the step (2) of step (3) gained, step (4), step (5), step (6) gained
Fine powder mixes, Co60 radiation sterilization, is dried, is pressed into the tablet that every weight is 30mg, is described treatment peripheral nerve and damages
The Chinese and Western compound medicine of wound.
The drug effect of Chinese medicine used by the present invention is as follows:
Caulis fici pumilae (Fructus Fici Pumilae): promoting blood circulation and detoxication.For rheumatic arthralgia, dysentery gonorrhea, traumatic injury, carbuncle furuncle." medium-height grass is commonly used in Shanghai
Medicine " carry: " wind-damp dispelling, dredge the meridian passage, clearing heat for detumescence, diuresis hemostasis, dispelling the wind and dampness pathogens pain, brothers' articular instability.”
Cortex Seu Folium Actinodaphnes Pilosae: promoting blood circulation and stopping pain, removing toxic substances and promoting subsidence of swelling.For traumatic pain, sciatica, stomachache, furuncle toxic swelling." Luchuan
Book on Chinese herbal medicine " carry: " wind dispelling is subsided a swelling, and removing mass detoxifies, and controls traumatic injury, furuncle toxic swelling.”
Foliumet Ramulus Evodiae: heat-clearing and toxic substances removing, eliminating stasis to stop pain.For high heat of catching a cold, tonsillitis, pharyngolaryngitis, lung abscess, pneumonia malaria
Disease, rheumatic arthritis, sciatica, lumbago and skelalgia, stomachache, icterohepatitis, osteopatia sprain, worm venom, carbuncle furuncle and phyma poison,
Trauma infection contamination, eczematous dermatitis.
Herba Lycopodii Obscuri: expelling wind and removing dampness, channels sootheing and network vessel quickening, blood circulation promoting and blood stasis dispelling.For rheumatic arthralgia, lumbago and skelalgia, numb limbs and tense tendons, traumatic injury is turned round
Wound, poliomyelitis." not Lu " carries: " QI invigorating is quenched the thirst.”
Radix fici panduratae: promoting flow of QI and blood, relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, galactostasis, traumatic injury, lumbago pain, mammary gland
Scorching." Fujian Chinese herbal medicine " carries: " blood-activating and qi-promoting, channels sootheing and network vessel quickening.”
Herba speranskiae cantonensis: dispel wind and remove dampness, promoting blood flow to regulate menstruation, pain relieving.For catching a cold, cough due to consumptive disease, tuberculous lymphadenitis, rheumatism joint
Inflammation, sciatica, traumatic injury, menoxenia, leucorrhea." Chinese herbal medicine is commonly used in Sichuan " carries: " wind-damp dispelling, the meridian dredging, disappear heavily fortified point
Block, promoting blood circulation and stopping pain, control enclosed mass in abdomen, tuberculous lymphadenitis, rheumatic ostalgia, chronic consumptive disease cough, sore tumor.”
Radix et Rhizoma Smilacis Ripariae: dispelling, collateral-activating, expelling phlegm for arresting cough.For rheumatic arthritis, bones and muscles pain, traumatic injury, lumbar muscle strain,
Bronchitis, pulmonary tuberculosis cough spitting of blood." Shaanxi Chinese herbal medicine " carries: " wind-damp dispelling, promoting blood circulation to remove obstruction in the collateral, anti-inflammatory analgesic, treating rheumatic joint
Inflammation, bones and muscles pain, the hemiplegia of caused by hypertension, osteomyelitis, bone tuberculosis.”
Radix Ligustici Brachylobi: deliver and dispel the wind.For anemofrigid cold, flu folder is wet, has a headache giddy, and cold-damp is suffered from abdominal pain, and has loose bowels, rheumatism numbness
Bitterly, spasm of the limbs, tetanus, conjunctival congestion skin infection, hernia abdominal mass scabies.
Radix anthrisci: replenishing QI to invigorate the spleen, promoting blood circulation and stopping pain.For splenasthenic abdominal distention, weak lack of appetite, cough due to deficiency of the lung, body void spontaneous perspiration, old man night
Frequent micturition number, deficiency of vital energy edema, impairment caused by overstrain lumbago, dysmenorrhea of having a headache, traumatic injury congestive edema." Traditional Chinese Medicine in Sichuan will " carries: " invigorating the spleen and replenishing QI, for insufficiency of the spleen
Flatulence due to improper diet, limbs fatigue, cough and asthma due to lung deficiency, old man's nocturia, and consumer edema.”
Radix Dipsaci: invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating.For aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy metrorrhagia, leukorrhagia is passed out semen, is fallen
Playing damage, incised wound anal fistula, carbuncle skin ulcer swells." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " tonifying liver, bone and muscle strengthening, walk meridians, antiabortive, controls married woman leucorrhea, raw
Fresh blood, removing blood stasis with potent drugs blood, fall dead a word used in place name, and cough-relieving is coughed hemoptysis, controls red white turbid urine.”
Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati): liver heat removing, invigorates blood circulation, pain relieving.For hypertension, menoxenia, injured bone, skin infection." Guangxi Chinese medicinal herbal "
Carry: " dissipating blood stasis continues muscle, bone-setting pain stopping, controls injured.”
Semen Nelumbinis: tonifying spleen and stopping diarrhea, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.For insufficiency of the spleen chronic diarrhea, leukorrhagia of passing out semen, palpitation and insomnia." herbal classic "
Carry: " main invigorating middle warmer, reposes, physical strength profiting.”
Fructus Rosae Laevigatae: reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal.For the spermatorrhea enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung breathes with cough, spontaneous perspiration
Night sweat, bleeding not during menses." book on Chinese herbal medicine is just " carries: " emesis blood, born fluid receive sweating due to debility, hold back asthenic fire, benefit marrow, strengthening bone and muscle, mend five Tibetan, support
Vim and vigour, flat cough, Dingchuan is anxious, treats severe palpitation palpitation with fear.”
The present invention compared with prior art, has the advantages that
Medicine of the present invention uses the Therapeutic Method of the combinat ion of Traditional Chinese Medicine and Pharmacy with Western Pharmacy to use Chinese medicine, western medicine effect more than the most simple
Good, there is expelling wind and removing dampness, strong muscles and bones, promoting blood circulation and stopping pain, the effect of channels sootheing and network vessel quickening, can with the raising Chinese medicine ingredients of maximal efficiency with
Western medicine effect, plays complementary and castering action, improves medicinal effects, it is possible to blood circulation promoting, improve numb limbs and tense tendons, to surrounding
The symptoms such as the myalgia of nerve injury initiation, paraesthesia, the dyskinesia have good therapeutic effect, can quickly repair
Nerve, promotes neurological functional recovery.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of ingredient of the present invention forms and weight is: Caulis fici pumilae (Fructus Fici Pumilae) 80 parts, 77 parts of Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae 75 parts, Herba Lycopodii Obscuri
73 parts, Radix fici panduratae 70 parts, Herba speranskiae cantonensis 65 parts, Radix et Rhizoma Smilacis Ripariae 62 parts, Radix Ligustici Brachylobi 60 parts, Radix anthrisci 58 parts, Radix Dipsaci 55 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 53
Part, 51 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 50 parts, profenamine 1.4 parts, carbamazepine 1.2 parts, Zaleplon 1.1 parts.
The processing step of process for preparing medicine of the present invention is:
(1) Caulis fici pumilae (Fructus Fici Pumilae), Cortex Seu Folium Actinodaphnes Pilosae, Herba Lycopodii Obscuri, Herba speranskiae cantonensis and Semen Nelumbinis are placed in container, add relative mixture quality 6～8 times
Amount distilled water immersion 2～after 3 days, add 3～4 times amount mass concentration be 45%～55% ethanol, be heated to reflux 4 hours,
Filter, obtain extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, are heated to reflux 2
Hour；Filter, obtain extracting solution；Merge twice extracting solution, filter, obtain filtrate, be cooled to room temperature, be concentrated into water content be 30%～
The extractum of 40%, standby；
(2) Foliumet Ramulus Evodiae, Radix Ligustici Brachylobi and Radix Dipsaci being cleaned, immersion runs through, and takes out section, and the saline spraying equimultiple is mixed thoroughly,
Slow fire fried dry, taking-up is dried in the air cool, is ground into powder, obtained the fine powder of 200 mesh in being placed in mortar, standby；
(3) Radix fici panduratae and Radix et Rhizoma Smilacis Ripariae are cleaned, juice of squeezing out in being placed in juice extractor, cold preservation 4 hours, filter, remove impurity
With precipitate, carry out desolventing technology through activated carbon adsorption, be concentrated into the extractum that water content is 30%～40%, standby；
(4) Radix anthrisci and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) are shredded, dry, sieve dedusting bits, grind into powder in being placed in mortar, obtained the fine powder of 160 mesh,
Standby；
(5) Fructus Rosae Laevigatae is slightly soaked, run through, rip cutting two lobe, remove hair, core, be placed at 200 DEG C～220 DEG C drying, taking-up is dried in the air
Cool, grind into powder in being placed in mortar, obtained the fine powder of 180 mesh, standby；
(6) grind into powder in profenamine, carbamazepine and Zaleplon being placed in mortar, obtained the fine powder of 220 mesh, standby
With；
(7) by step (1), extractum and the step (2) of step (3) gained, step (4), step (5), step (6) gained
Fine powder mixes, Co60 radiation sterilization, is dried, is pressed into the tablet that every weight is 30mg, is described treatment peripheral nerve and damages
The Chinese and Western compound medicine of wound.
Usage and dosage: oral, each 2, every 30mg, every day 2 times, the most once, after 1 hour after meal, warm water send
Clothes, 10 days are a course for the treatment of, usual 2～3 courses for the treatment of of recovery from illness, and pertinacious disease needs 4～5 recoveries from illness courses for the treatment of, anemia of pregnant woman, women breast-feeding their children and right
This product allergy sufferers disables.
Embodiment 2
The raw material of ingredient of the present invention forms and weight is: Caulis fici pumilae (Fructus Fici Pumilae) 74 parts, 71 parts of Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae 69 parts, Herba Lycopodii Obscuri
67 parts, Radix fici panduratae 64 parts, Herba speranskiae cantonensis 59 parts, Radix et Rhizoma Smilacis Ripariae 57 parts, Radix Ligustici Brachylobi 55 parts, Radix anthrisci 53 parts, Radix Dipsaci 49 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 47
Part, 45 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 44 parts, profenamine 1.1 parts, carbamazepine 0.8 part, Zaleplon 0.8 part.
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of ingredient of the present invention forms and weight is: Caulis fici pumilae (Fructus Fici Pumilae) 67 parts, 64 parts of Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae 62 parts, Herba Lycopodii Obscuri
60 parts, Radix fici panduratae 57 parts, Herba speranskiae cantonensis 52 parts, Radix et Rhizoma Smilacis Ripariae 50 parts, Radix Ligustici Brachylobi 47 parts, Radix anthrisci 46 parts, Radix Dipsaci 42 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 40
Part, 38 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 37 parts, profenamine 0.9 part, carbamazepine 0.6 part, Zaleplon 0.5 part.
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of ingredient of the present invention forms and weight is: Caulis fici pumilae (Fructus Fici Pumilae) 59 parts, 55 parts of Cortex Seu Folium Actinodaphnes Pilosae, Foliumet Ramulus Evodiae 54 parts, Herba Lycopodii Obscuri
53 parts, Radix fici panduratae 49 parts, Herba speranskiae cantonensis 44 parts, Radix et Rhizoma Smilacis Ripariae 41 parts, Radix Ligustici Brachylobi 40 parts, Radix anthrisci 35 parts, Radix Dipsaci 34 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 33
Part, 30 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 29 parts, profenamine 0.7 part, carbamazepine 0.4 part, Zaleplon 0.3 part.
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Toxicity test:
One, acute toxicity test:
1, test procedure: randomly selecting healthy mice 50, male and female half and half, body weight 16～25g, mice is randomly divided into two
Group, i.e. experimental group and matched group, after testing front all fasting 16 hours, respectively by the perfusion amount that gavage volume is 5ml/kg to experiment
Group and matched group carry out perfusion, and experimental group is selected in 1 water being dissolved in 10ml of compound medicine of Chinese and Western of the present invention, and matched group is chosen
The normal saline of equivalent, experimental group and matched group homogeneous sky perfusion 3 times, perfusion interval time is 8 hours, Continuous Observation after perfusion
15 days, and according to the toxic reaction degree of evaluation methodology record mice and death toll.
2, evaluation methodology:
3, there is not death in result: acute toxicity test mice perfusion postabdomen has no irritant reaction, breathes normal, body
Body is healthy, body weight does not declines, and after dissecting it accordingly, tissue or internal organs have no obvious abnormal change.
Two, long term toxicity test
1, test procedure: randomly selecting healthy rat 50, male and female half and half, body weight 200～220g, rat is randomly divided into two
Group, i.e. experimental group and matched group, after testing front all fasting 16 hours, respectively by the perfusion amount that gavage volume is 5ml/kg to experiment
Group and matched group carry out perfusion, and experimental group is selected in 1 water being dissolved in 40ml of compound medicine of Chinese and Western of the present invention, and matched group is chosen
The normal saline of equivalent, experimental group and matched group equal perfusion every day in the 1st～30 day 3 times, perfusion interval time is 8 hours, after
Every 5 hours be incremented by 1.3 multiple doses, perfusion 100 days, according to the evaluation methodology record rat in acute toxicity test toxicity anti-
Answer degree and death toll.
2, there is not death in result: long term toxicity test rat perfusion postabdomen has no irritant reaction, breathes normal, right
Defecation, body weight, organ weights, hepatic and renal function, blood fat etc. all have no significant effect.
Clinical data:
1, case selection:
Selecting the peripheral nerve injury patient 498 example clinical observation that my institute or outer court make a definite diagnosis, patient is randomly divided into three groups, controls
Treatment group, control group A, the every scope of matched group B are as follows:
| Project | Treatment group | Control group A | Matched group B |
| Number of cases | 166 examples | 166 examples | 166 examples |
| M-F | 1∶1 | 41∶42 | 1∶1 |
| The range of age | 18 years old～65 years old | 19 years old～64 years old | 19 years old～65 years old |
| Mean age | 32.7 years old | 32 years old | 33.4 years old |
| The course of disease | 3 months～6 years | 2 months～5 years | 3 months～5 years |
The course of disease of three groups of cases, degrees of symptoms are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group patient takes Chinese and Western of the present invention compound medicine, oral, each 2, every 30mg, every day 2 times, the most each
Once, after 1 hour after meal, warm water takes, and within 10 days, is a course for the treatment of, and usual 2～3 courses for the treatment of of recovery from illness, pertinacious disease needs fully recover from an illness 4～5 courses for the treatment of
More, anemia of pregnant woman, women breast-feeding their children and this product allergy sufferers is disabled.
Control group A takes three-dimensional B sheet, oral, one time 1～2,3 times on the one.
Matched group B injects Mecobalamin injection, 1 ampoule (containing mecobalamin 0.5mg) of being grown up, 1 time on the one, one week 3 times,
Intramuscular injection or intravenous injection, can by age, symptom take the circumstances into consideration increase and decrease.
3, efficacy determination:
(1) cure: the transference cures such as the dyskinesia, sensory disturbance, amyotrophy；Activity freely, physical recovery healthy.
(2) effective: above-mentioned symptom has been alleviated.
(3) invalid: above-mentioned symptom is unchanged.
4, result:
| Group | Number of cases (example) | Cure (example) | Effectively (example) | Invalid (example) | Cure rate | Total effective rate |
| Treatment group | 166 | 141 | 14 | 11 | 84.9% | 93.4% |
| Control group A | 166 | 103 | 18 | 45 | 62% | 72.9% |
| Matched group B | 166 | 96 | -15 | 55 | 57.8% | 66.9% |
Result above shows, treatment group cure rate and total effective rate are apparently higher than control group A, matched group B.
Model case is illustrated:
1, horse ××, female, 20 years old, student.Patient causes nerve compression because of fracture dislocation, causes peripheral nerve injury, on
Limb is sagging, adduction of the upper limb, it is impossible to abduction outward turning, receives and stretch in forearm, it is impossible to supination or bending, omoplate, upper arm and forearm before rotation
All can not autonomic activities, after taking 2 courses for the treatment of of medicine of the present invention, above transference cure, physical recovery is healthy, follows up a case by regular visits to the most multiple
Send out.
2, Song's ××, man, 28 years old, millworker.Patient suffers from peripheral nerve injury nearly 1 year, once takes other multiple
Medicine, effect is the most inconspicuous.Recommend to take 2 courses for the treatment of of medicine of the present invention, health gradually rehabilitation through people, continue to take 1 course for the treatment of,
Freely, health is fully recovered, and follows up a case by regular visits to not recur so far in activity.
3, poplar ××, female, 34 years old, section chief.Patient causes peripheral nerve injury because of wound, and especially median nerve injury is relatively
Seriously, first, second and third refers to flexing defunctionalization, and thumb opposition is lost, forefinger, middle finger minor details anesthesia.Take the present invention
After 1 course for the treatment of of medicine, symptom takes a turn for the better, and continues to take 1 course for the treatment of, transference cure, sensory recovery, not recurrence.
4, king's ××, man, 45 years old, sales manager.Patient suffers from damaged peripheral nerves 3 years, period intermittent medication, has
Taken a turn for the better, but sensation legs and feet are the most unable recently, difficulty in walking, aggravation.Recommend to take medicine of the present invention 2 treatment through people
Journey, symptom is clearly better, and continues to take 2 courses for the treatment of, transference cure.
5, model ××, female, 58 years old, retired professor.Patient's arm, lower limb, the back of the body, finger all have pain, after physics physical therapy
Having taken a turn for the better, but Short-term Pain increases the weight of, I does electromyography at institute then, is diagnosed as peripheral nerve injury.Take the present invention
After 2 courses for the treatment of of medicine, symptom takes a turn for the better, and continues to take 1 course for the treatment of, transference cure, and physical recovery is healthy, follows up a case by regular visits to not recur so far.
6, ×× slowly, man, 64 years old, peasant.Patient causes peripheral nerve injury, brachia plexus injury, axil because of stretch injury
Nerve injury, injury of sciatic nerve, radial nerve injury are particularly acute, and the dyskinesia, sensory disturbance and malnutrition occur.Take
After 2 courses for the treatment of of medicine of the present invention, symptom substantially alleviates, and then takes 3 courses for the treatment of, and physical recovery is normal, activity freely, follow up a case by regular visits to
The present does not recurs.
Claims (5)
1. the Chinese and Western compound medicine treating peripheral nerve injury, it is characterised in that: described medicine is by Chinese medicine and western medicine composition
Composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Caulis fici pumilae (Fructus Fici Pumilae) 51～81 parts, Cortex Seu Folium Actinodaphnes Pilosae 48～78 parts, trident
Bitter 46～76 parts, Herba Lycopodii Obscuri 44～74 parts, Radix fici panduratae 41～71 parts, Herba speranskiae cantonensis 36～66 parts, Radix et Rhizoma Smilacis Ripariae 33～63 parts, Radix Ligustici Brachylobi 31
～61 parts, Radix anthrisci 29～59 parts, Radix Dipsaci 26～56 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 24～54 parts, Semen Nelumbinis 22～52 parts, Fructus Rosae Laevigatae 21～51 parts；
Make described western medicine composition raw material composition and parts by weight be: profenamine 0.6～1.5 parts, carbamazepine 0.3～1.3 parts,
Zaleplon 0.1～1.2 parts.
A kind of Chinese and Western compound medicine treating peripheral nerve injury the most according to claim 1, it is characterised in that: described medicine
Thing is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Caulis fici pumilae (Fructus Fici Pumilae) 74 parts, Cortex Seu Folium Actinodaphnes Pilosae
71 parts, Foliumet Ramulus Evodiae 69 parts, Herba Lycopodii Obscuri 67 parts, Radix fici panduratae 64 parts, Herba speranskiae cantonensis 59 parts, Radix et Rhizoma Smilacis Ripariae 57 parts, Radix Ligustici Brachylobi 55 parts, Radix anthrisci 53
Part, Radix Dipsaci 49 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 47 parts, 45 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 44 parts；Make raw material composition and the weight portion of described western medicine composition
Number is: profenamine 1.1 parts, carbamazepine 0.8 part, Zaleplon 0.8 part.
A kind of Chinese and Western compound medicine treating peripheral nerve injury the most according to claim 1, it is characterised in that: described medicine
Thing is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Caulis fici pumilae (Fructus Fici Pumilae) 67 parts, Cortex Seu Folium Actinodaphnes Pilosae
64 parts, Foliumet Ramulus Evodiae 62 parts, Herba Lycopodii Obscuri 60 parts, Radix fici panduratae 57 parts, Herba speranskiae cantonensis 52 parts, Radix et Rhizoma Smilacis Ripariae 50 parts, Radix Ligustici Brachylobi 47 parts, Radix anthrisci 46
Part, Radix Dipsaci 42 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 40 parts, 38 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 37 parts；Make raw material composition and the weight portion of described western medicine composition
Number is: profenamine 0.9 part, carbamazepine 0.6 part, Zaleplon 0.5 part.
A kind of Chinese and Western compound medicine treating peripheral nerve injury the most according to claim 1, it is characterised in that: described medicine
Thing is made up of Chinese medicine and western medicine composition, make described Chinese medicine ingredients raw material composition and parts by weight be: Caulis fici pumilae (Fructus Fici Pumilae) 59 parts, Cortex Seu Folium Actinodaphnes Pilosae
55 parts, Foliumet Ramulus Evodiae 54 parts, Herba Lycopodii Obscuri 53 parts, Radix fici panduratae 49 parts, Herba speranskiae cantonensis 44 parts, Radix et Rhizoma Smilacis Ripariae 41 parts, Radix Ligustici Brachylobi 40 parts, Radix anthrisci 35
Part, Radix Dipsaci 34 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 33 parts, 30 parts of Semen Nelumbinis, Fructus Rosae Laevigatae 29 parts；Make raw material composition and the weight portion of described western medicine composition
Number is: general
Sieve fen amine 0.7 part, carbamazepine 0.4 part, Zaleplon 0.3 part.
5. a preparation method for the Chinese and Western compound medicine of the treatment peripheral nerve injury as described in any one of Claims 1 to 4,
It is characterized in that: comprise the following steps that:
(1) Caulis fici pumilae (Fructus Fici Pumilae), Cortex Seu Folium Actinodaphnes Pilosae, Herba Lycopodii Obscuri, Herba speranskiae cantonensis and Semen Nelumbinis are placed in container, add relative mixture quality 6～8 times amount
Distilled water immersion 2～after 3 days, the mass concentration adding 3～4 times amount is 45%～55% ethanol, is heated to reflux 4 hours, filters,
Extracting solution；The medicinal residues obtained after filtering add the distilled water of relative medicinal residues quality 4～6 times amount, are heated to reflux 2 hours；Cross
Filter, obtains extracting solution；Merge twice extracting solution, filter, obtain filtrate, be cooled to room temperature, be concentrated into the leaching that water content is 30%～40%
Cream, standby；
(2) Foliumet Ramulus Evodiae, Radix Ligustici Brachylobi and Radix Dipsaci being cleaned, immersion runs through, and takes out section, and the saline spraying equimultiple is mixed thoroughly, slow fire
Fried dry, taking-up is dried in the air cool, is ground into powder, obtained the fine powder of 200 mesh in being placed in mortar, standby；
(3) Radix fici panduratae and Radix et Rhizoma Smilacis Ripariae are cleaned, juice of squeezing out in being placed in juice extractor, cold preservation 4 hours, filter, remove impurity with heavy
Shallow lake thing, carries out desolventing technology through activated carbon adsorption, is concentrated into the extractum that water content is 30%～40%, standby；
(4) Radix anthrisci and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) are shredded, dry, sieve dedusting bits, grind into powder in being placed in mortar, obtained the fine powder of 160 mesh, standby
With；
(5) Fructus Rosae Laevigatae is slightly soaked, run through, rip cutting two lobe, remove hair, core, be placed at 200 DEG C～220 DEG C drying, taking-up is dried in the air cool,
Grind into powder in being placed in mortar, obtained the fine powder of 180 mesh, standby；
(6) grind into powder in profenamine, carbamazepine and Zaleplon being placed in mortar, obtained the fine powder of 220 mesh, standby；
(7) by step (1), extractum and step (2), step (4), step (5), the fine powder of step (6) gained of step (3) gained
Mixing, Co60 radiation sterilization, it is dried, is pressed into the tablet that every weight is 30mg, be described treatment peripheral nerve injury
Chinese and Western compound medicine.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109298148A (en) * | 2018-09-14 | 2019-02-01 | 陇东学院 | A method of assessment promotees nerve regneration drug potency |
| CN113648403A (en) * | 2021-09-13 | 2021-11-16 | 四川省科学城医院 | Medicine for recovering normal conduction function of nerves and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109298148A (en) * | 2018-09-14 | 2019-02-01 | 陇东学院 | A method of assessment promotees nerve regneration drug potency |
| CN113648403A (en) * | 2021-09-13 | 2021-11-16 | 四川省科学城医院 | Medicine for recovering normal conduction function of nerves and preparation method thereof |
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Application publication date: 20161214 |