CN104127531A - Traditional Chinese medicine composition for treating enterogastritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating enterogastritis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese medicine composition for treating enterogastritis and a preparation method thereof. The traditional Chinese medicine composition for treating or preventing enterogastritis is prepared from the following components in parts by weight: 6-13 parts of scutellaria baicalensis, 2-12 parts of rheum officinale, 1-15 parts of hawthorn, 10-15 parts of elecampane, 10-15 parts of spotted ardiaia herb, 5-15 parts of endothelium corneum gigeriae galli, 2-10 parts of coptis chinensis and 10-15 parts of liquorice. The traditional Chinese medicine composition provided by the invention shows remarkable anti-inflammatory activity especially for treating acute gastroenteritis and has a remarkable dose-effect relationship.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of gastroenteritis and preparation method thereof.
Background technology
Gastritis is the gastric mucosa inflammation that any cause of disease causes, often with epithelial damage and cell regeneration.When gastric mucosa inflammation lacks as or when very light, this kind of gastric mucosal lesions should be called gastropathy.Gastritis is one of modal digestive system disease.Enteritis is enteritis and the colitis that antibacterial, virus, fungus and parasite etc. cause.Clinical manifestation mainly contains stomachache, diarrhoea, rare aquiform stool or mucus bloody purulent stool.Part patient can have heating and tenesmus sensation, therefore also claim infectious diarrhea.Enteritis, by course of disease length difference, is divided into acute and chronic two classes.The chronic enteritis course of disease generally more than two months, clinical chronic bacillary dysentery, chronic amebic dysentery, schistosomicide, nonspecific ulcerative colitis and the limit office enteritis etc. of common are.
The traditional Chinese medical science thinks, the many gas damp and hot because being subject to outward, that epidemic disease is malicious of primary disease, and internal injury diet raw food, impairing the spleen and stomach and internal organs form, and belong to " intestinal is warded off, gastroenteritis " category." the bright opinion of the lunar sun of Plain Questions " cloud: " eating and drinking without temperance, daily life frequently ... let out for offering to down, for a long time for intestinal is warded off.", " Zhengzi Huibu " pointed out: " the intestinal person of warding off calls damp and hot amassing in intestinal. be modern gastroenteritis also, therefore say without disease not become to rush down, rush down be wet, heat, food stagnation three ".In treatment, should take the method for determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Jing-Yue Complete Works cloud: " all gastroenteritis of controlling, ought examine deficiency and excess, distinguishes cold and heat, and this rushes down maximum relation, if four not clear, kills a person very easily also.", therefore that the dialectical head of primary disease distinguishes is cold, hot, empty, real, face card when according to stomachache, tenesmus, rush down color, and refer and synthesize tongue arteries and veins and distinguish.Damp-heat type is to suffer from abdominal pain, to rush down lower red white pus and blood, yellow and greasy fur, slippery and rapid pulse as dialectical main points.Pathogenesis is that damp and hot heresy is invaded the intestines and stomach, QI and blood retardance, and stagnation of QI and blood may bring about pain, thus stomachache, tenesmus; Damp and hot stasis is in large intestine, and meridians are impaired, therefore the red white pus and blood that drops; Yellow and greasy fur, slippery and rapid pulse are damp and hot resembling.The suitable clearing away heat and eliminating dampness of the rule for the treatment of, regulating QI promoting the circulation of blood.
In prior art, chemicals is cured the symptoms, not the disease, and easily damages gastrointestinal tract mucously, and poisonous side effect of medicine is large, the invention discloses a kind of Chinese medicine composition for the treatment of acute gastroenteritis, this Chinese medicine composition good effect, side effect is little, it is made by the raw material of following weight portion: Radix Scutellariae 6-13 part, Radix Et Rhizoma Rhei 2-12 part, Fructus Crataegi 1-15 part, Radix Aucklandiae 10-15 part, Herba Ardisiae Maculosae 10-15 part, Endothelium Corneum Gigeriae Galli 5-15 part, Rhizoma Coptidis 2-10 part, Radix Glycyrrhizae 10-15 part.
In Chinese medicine composition of the present invention, described Radix Scutellariae another name Radix Scutellariae, tsuchikane tea root.For labiate Radix Scutellariae (Scutellaria baicalensis Georgi), be used as medicine with root.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Chuanxiong, and does not develop immunity to drugs.
Radix Et Rhizoma Rhei, nature and flavor hardship, cold; Gui Jing enters stomach, large intestine, Liver Channel.Function cures mainly: the poison that purges heat, removing mass is stagnant, clots absorbing blood.Control excess-heat constipation, delirium is sent out holder, food stagnation feeling of fullness, dysentery is from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, also urinates, carbuncle and ulcer toxic swelling, furuncle, burn.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation., jaundice due to damp-heat not well for excess-heat constipation, stagnant stomachache, dysentery.
Fructus Crataegi, meridian distribution of property and flavor acid, sweet, tepor.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
The Radix Aucklandiae is the common name of feverfew Saussurea lappa Clarke and Radix Vladimiriae.Another name: honey perfume, Radix Aristolochiae, spices, five Radix Aucklandiae, Radix Aristolochiae yunnanensis, Radix Aucklandiae (Radix Vladimiriae), Saussurea lappa Clarke.There are promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune; The spleen invigorating stagnant effect that disappears, but the careful clothes of deficiency of YIN deficiency of body fluid person.Circulation of qi promoting is stagnant should give birth to use, and antidiarrheal dysentery should be simmered use.Fragrance should not be decocted for a long time.Vomit for abdominal distention, lack of appetite due to stagnation of QI in spleen and stomach, often join Fructus Amomi, Pericarpium Citri Reticulatae with using.The hypochondriac pain causing for QI stagnation of the liver and galibladder, can join Fructus Toosendan, Fructus Aurantii with using.Disappear for spleen invigorating stagnant, the stagnant gas of adjustable gastrointestinal.Treatment stomachache, diarrhoea, tenesmus, can join Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Amomi, the Rhizoma Pinelliae, Radix Aconiti Lateralis Preparata, red Poria and be equal to use.The pungent temperature of the Radix Aucklandiae is fragrant loose, can rise and can fall, and leads to the gas of managing three warmers, and the especially gas of benefaction gastrointestinal and pain relieving has the merit of strengthening the spleen to promote digestion concurrently, and all cards are conventional product due to all taste QI stagnation of the large intestine.
Herba Ardisiae Maculosae, nature and flavor are pungent, hardship, slightly warm in nature; Return through liver kidney, lung meridian; Function cures mainly promoting blood circulation and stopping pain, clearing throat.Main traumatic injury, fracture, rheumatic arthralgia, diphtheria, laryngopharynx swelling and pain, gastric ulcer.
Endothelium Corneum Gigeriae Galli, nature and flavor with return through sweet in the mouth, flat.Return spleen, stomach, small intestinal, urinary bladder channel.Function with cure mainly: help digestion long-pending, arresting enursis, the inducing decomposition of calculi.For edema abdominal distention, dysentery, food stagnation, regurgitation acid regurgitation, children's's infantile malnutrition, urinary system calculus, the enuresis.
Rhizoma Coptidis, nature and flavor with return through hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function with cure mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually damp and hot middle resistance, feeling of fullness vomiting for cold and heat.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Radix Glycyrrhizae, nature and flavor are sweet, flat.Gui Jing enters spleen, stomach, lung meridian.Function cures mainly: and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, and ulcer sores, separates poison of drug and alimentary toxicosis.
Chinese medicine thinks, gastroenteritis is many because eating and drinking without temperance, feelings will are hindered, overstrain is fallen ill, and according to the difference of the cause of disease and symptom, is divided into cold-damp, heat-damp in summer, deficiency and coldness, dyspepsia Four types, and patient should basis, and clinical manifestation, reasonably selects food, dialectical treating.Chinese medicine composition of the present invention takes into full account cold expelling, damp eliminating on Chinese medicinal components is selected, and Chinese medicine composition of the present invention has significant antiphlogistic effects simultaneously.The present invention has carried out preferably the parts by weight of above-mentioned all taste Chinese medicine, and preferred condition is the enhancing of medicine to acute gastroenteritis therapeutic effect after Chinese medicine and western medicine compatibility uses.As a most preferred embodiment of the present invention, Chinese medicine composition of the present invention is mainly made by the raw material of following weight portion: 10 parts of Radix Scutellariaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Fructus Crataegis, 12 parts of the Radix Aucklandiae, 12 parts of Herba Ardisiae Maculosaes, 9 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Rhizoma Coptidis, 12 parts, Radix Glycyrrhizae.
In order to express better Chinese medicine composition of the present invention, Chinese medicine composition of the present invention can be prepared into conventional clinically dosage form.Such as, powderous preparations, powder, pill, sublimed preparation, unguentum, granule, tablet, capsule etc.Preferably, Chinese medicine composition of the present invention is prepared into tablet, capsule, granule according to conventional preparation technology.
The present invention also provides a kind of preparation method of Chinese medicine composition described above, and it mainly comprises following step: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 4-9 times of water gaging, soaks 0.5-3 hour, and distillation extraction 2-5 hour collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 4-12 times of decocting that add water boils 1-3 time, at every turn 0.5-3 hour, merge decoction liquor, adding ethanol to concentration is 40-80%, places 12-48 hour, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make clinical receptible various dosage forms by conventional formulation method.As tablet, capsule, granule etc.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment acute gastroenteritis medicine.Pharmaceutical composition of the present invention, in the time for the treatment of acute gastroenteritis, demonstrates significant anti-inflammatory activity.Drug effect embodiment 8 of the present invention shows, with model group comparison, the low middle Senior Three of a Chinese medicine composition of the present invention dosage group all can significantly suppress proinflammatory effect (the P < 0.01 of the auricle edema that dimethylbenzene causes, P < 0.05), show that Chinese medicine composition of the present invention has the effect of the mice ear of remarkable inhibition dimethylbenzene induction, and there is significant dose-effect relationship in its reduction effect to ear swelling.Under same experiment condition, positive control drug gastroenteritis Yiganning capsule group also significantly reduces ear swelling value (P < 0.01).
The present invention is that inventor is through research repeatedly, progressively improve, last successful a kind of curative effect is treated the medicine of acute gastroenteritis preferably, for showing the therapeutic effect of medicine of the present invention to acute gastroenteritis, the gastroenteritis patient that the present invention takes this medicine to 211 examples has carried out clinical observation, obtain good curative effect, in 211 routine patients, medication, after 4 days, is cured 177 examples, cure rate accounts for 83.88%, 33 examples that take a turn for the better, obvious effective rate accounts for 15.64%, total effective rate 99.53%, invalid 1 example, inefficiency accounts for 0.47%.
Summary of the invention
Detailed description of the invention
Further describe the present invention by specific embodiment below, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, change, combination or replacement that the present invention is carried out, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: 10 parts of Radix Scutellariaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Fructus Crataegis, 12 parts of the Radix Aucklandiae, 12 parts of Herba Ardisiae Maculosaes, 9 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Rhizoma Coptidis, 12 parts, Radix Glycyrrhizae;
Preparation method: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 6 times of water gagings, soaks 2 hours, and distillation extraction 3.5 hours, collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 8 times of decoctings that add water boil 2 times, each 2 hours, merge decoction liquor, adding ethanol to concentration is 75%, places 24 hours, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make tablet by conventional formulation method.
Embodiment 2
Prescription: 10 parts of Radix Scutellariaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Fructus Crataegis, 12 parts of the Radix Aucklandiae, 12 parts of Herba Ardisiae Maculosaes, 9 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Rhizoma Coptidis, 12 parts, Radix Glycyrrhizae;
Preparation method: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 6 times of water gagings, soaks 2 hours, and distillation extraction 3.5 hours, collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 8 times of decoctings that add water boil 2 times, each 2 hours, merge decoction liquor, adding ethanol to concentration is 75%, places 24 hours, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make capsule by conventional formulation method.
Embodiment 3
Prescription: 6 parts of Radix Scutellariaes, 2 parts of Radix Et Rhizoma Rhei, 1 part of Fructus Crataegi, 10 parts of the Radix Aucklandiae, 10 parts of Herba Ardisiae Maculosaes, 5 parts of Endothelium Corneum Gigeriae Galli, 2 parts of Rhizoma Coptidis, 10 parts, Radix Glycyrrhizae;
Preparation method: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 9 times of water gagings, soaks 1 hour, and distillation extraction 2 hours, collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 12 times of decoctings that add water boil 1 time, each 0.5 hour, merge decoction liquor, adding ethanol to concentration is 40%, places 48 hours, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make tablet by conventional formulation method.
Embodiment 4
Prescription: 13 parts of Radix Scutellariaes, 12 parts of Radix Et Rhizoma Rhei, 15 parts of Fructus Crataegis, 15 parts of the Radix Aucklandiae, 15 parts of Herba Ardisiae Maculosaes, 15 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Coptidis, 15 parts, Radix Glycyrrhizae;
Preparation method: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 4 times of water gagings, soaks 3 hours, and distillation extraction 5 hours, collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 4 times of decoctings that add water boil 3 times, each 3 hours, merge decoction liquor, adding ethanol to concentration is 80%, places 12 hours, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make tablet by conventional formulation method.
Embodiment 5
Prescription: 6 parts of Radix Scutellariaes, 12 parts of Radix Et Rhizoma Rhei, 1 part of Fructus Crataegi, 15 parts of the Radix Aucklandiae, 10 parts of Herba Ardisiae Maculosaes, 15 parts of Endothelium Corneum Gigeriae Galli, 2 parts of Rhizoma Coptidis, 15 parts, Radix Glycyrrhizae;
Preparation method: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 9 times of water gagings, soaks 0.5 hour, and distillation extraction 2 hours, collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 4 times of decoctings that add water boil 1 time, each 3 hours, merge decoction liquor, adding ethanol to concentration is 60%, places 24 hours, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make tablet by conventional formulation method.
Embodiment 6
Prescription: 13 parts of Radix Scutellariaes, 2 parts of Radix Et Rhizoma Rhei, 15 parts of Fructus Crataegis, 10 parts of the Radix Aucklandiae, 15 parts of Herba Ardisiae Maculosaes, 5 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Coptidis, 10 parts, Radix Glycyrrhizae;
Preparation method: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 6 times of water gagings, soaks 0.5 hour, and distillation extraction 5 hours, collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 6 times of decoctings that add water boil 2 times, each 2 hours, merge decoction liquor, adding ethanol to concentration is 75%, places 24 hours, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make tablet by conventional formulation method.
Embodiment 7
Prescription: 10 parts of Radix Scutellariaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Fructus Crataegis, 12 parts of the Radix Aucklandiae, 12 parts of Herba Ardisiae Maculosaes, 9 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Rhizoma Coptidis, 12 parts, Radix Glycyrrhizae;
Preparation method: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 6 times of water gagings, soaks 2 hours, and distillation extraction 3.5 hours, collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 8 times of decoctings that add water boil 2 times, each 2 hours, merge decoction liquor, adding ethanol to concentration is 75%, places 24 hours, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, with the agent of conventional formulation method granulation.
Embodiment 8 Chinese medicine composition xylol of the present invention causes the impact of mice ear
Get 50 of Kunming mouses, 20 ± 2g, ♀ ♂ half and half, divide 5 groups, 10/group, i.e. model group, gastroenteritis Yiganning capsule group (Shandong Xianhe Pharmaceutical Co., Ltd.), Chinese medicine composition of the present invention (making by Chinese medicine composition prescription and preparation technology described in embodiment 2) low dose group, middle dosage group and high dose group.1 time/d of every ig administration; Administration 4d, 60min after last medicine, the left ear of mice is evenly smeared dimethylbenzene 0.1mL/ and is only caused swollen, after 2h, cut ears, with 9mm card punch, in the punching of left and right auricle same area, both sides auricle is weighed respectively, using swelling rate as swelling level index, press formula and calculate, the difference between comparative drug group and matched group, the results are shown in Table 1.
Table 1. Chinese medicine composition xylol of the present invention causes the impact of mice ear
Note: with the comparison of model group group, * p<0.05, * * p<0.01.
Result shows, with model group comparison, the low middle Senior Three of a Chinese medicine composition of the present invention dosage group all can significantly suppress proinflammatory effect (the P < 0.01 of the auricle edema that dimethylbenzene causes, P < 0.05), show that Chinese medicine composition of the present invention has the effect of the mice ear of remarkable inhibition dimethylbenzene induction, and there is significant dose-effect relationship in its reduction effect to ear swelling.Under same experiment condition, positive control drug gastroenteritis Yiganning capsule group also significantly reduces ear swelling value (P < 0.01).
Claims (6)
1. treat a Chinese medicine composition for gastroenteritis, it is characterized in that it is made by the raw material of following weight portion: Radix Scutellariae 6-13 part, Radix Et Rhizoma Rhei 2-12 part, Fructus Crataegi 1-15 part, Radix Aucklandiae 10-15 part, Herba Ardisiae Maculosae 10-15 part, Endothelium Corneum Gigeriae Galli 5-15 part, Rhizoma Coptidis 2-10 part, Radix Glycyrrhizae 10-15 part.
2. Chinese medicine composition as claimed in claim 1, is characterized in that it is made by the raw material of following weight portion: 10 parts of Radix Scutellariaes, 8 parts of Radix Et Rhizoma Rhei, 8 parts of Fructus Crataegis, 12 parts of the Radix Aucklandiae, 12 parts of Herba Ardisiae Maculosaes, 9 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Rhizoma Coptidis, 12 parts, Radix Glycyrrhizae.
3. a method of preparing the Chinese medicine composition as described in claim 1,2, is characterized in that, comprises the following steps: Radix Scutellariae, Radix Et Rhizoma Rhei, Fructus Crataegi, Rhizoma Coptidis, Radix Glycyrrhizae alcohol reflux; The Radix Aucklandiae adds 4-9 times of water gaging, soaks 0.5-3 hour, and distillation extraction 2-5 hour collects volatile oil, adds appropriate beta-schardinger dextrin-and makes clathrate, and the another device of the medicinal residues after distillation and debris is deposited; After Herba Ardisiae Maculosae, Endothelium Corneum Gigeriae Galli and the Radix Aucklandiae extract medicinal residues after volatile oil, debris and Radix Scutellariae etc. and reflux, medicinal residues merge, and the 4-12 times of decocting that add water boils 1-3 time, at every turn 0.5-3 hour, merge decoction liquor, adding ethanol to concentration is 40-80%, places 12-48 hour, filter, alcohol deposit fluid and backflow merge, and decompression recycling ethanol, is concentrated into extractum, extract dry becomes fine powder, add volatile oil clathrate compound, then add appropriate amount of auxiliary materials and mix, make clinical receptible various dosage forms by conventional formulation method.
4. method as claimed in claim 3, is characterized in that, described dosage form is powderous preparations, powder, pill, sublimed preparation, unguentum, granule, tablet, capsule.
5. method as claimed in claim 4, is characterized in that, described dosage form is tablet, capsule, granule.
6. the purposes in preparation treatment acute gastroenteritis medicine of the Chinese medicine composition as described in claim 1,2.
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| CN104547356A (en) * | 2015-02-09 | 2015-04-29 | 柏伟伟 | Traditional Chinese medicine composition for treating heat evil attacking stomach type chronic gastritis |
| CN104905031A (en) * | 2015-05-20 | 2015-09-16 | 来英 | Pig gastroenteritis preventing and treating feed additive and production method thereof |
| CN105106354A (en) * | 2015-08-31 | 2015-12-02 | 刘高志 | Application of traditional Chinese medicine composition to preparation of medicine for treating allergic rhinitis |
| CN105125661A (en) * | 2015-09-16 | 2015-12-09 | 程俊 | Application of traditional Chinese medicinal composition to medicament for treating allergic rhinitis |
| CN105168512A (en) * | 2015-08-12 | 2015-12-23 | 彭刘平 | Traditional Chinese medicine for preparing medicine for treating allergic rhinitis |
| CN105770708A (en) * | 2016-05-23 | 2016-07-20 | 秦朝东 | Traditional Chinese medicine composition for treating summer attack enterogastritis |
| CN106215147A (en) * | 2016-08-22 | 2016-12-14 | 成都威迪视特生物科技有限公司 | A kind of for Chinese medicine synthetic treating flatulence and preparation method thereof |
| CN106266704A (en) * | 2016-09-13 | 2017-01-04 | 佛山市顺德区宝铜金属科技有限公司 | The Chinese medicine composition for the treatment of gastroenteritis and preparation method |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547356A (en) * | 2015-02-09 | 2015-04-29 | 柏伟伟 | Traditional Chinese medicine composition for treating heat evil attacking stomach type chronic gastritis |
| CN104905031A (en) * | 2015-05-20 | 2015-09-16 | 来英 | Pig gastroenteritis preventing and treating feed additive and production method thereof |
| CN105168512A (en) * | 2015-08-12 | 2015-12-23 | 彭刘平 | Traditional Chinese medicine for preparing medicine for treating allergic rhinitis |
| CN105106354A (en) * | 2015-08-31 | 2015-12-02 | 刘高志 | Application of traditional Chinese medicine composition to preparation of medicine for treating allergic rhinitis |
| CN105125661A (en) * | 2015-09-16 | 2015-12-09 | 程俊 | Application of traditional Chinese medicinal composition to medicament for treating allergic rhinitis |
| CN105770708A (en) * | 2016-05-23 | 2016-07-20 | 秦朝东 | Traditional Chinese medicine composition for treating summer attack enterogastritis |
| CN106215147A (en) * | 2016-08-22 | 2016-12-14 | 成都威迪视特生物科技有限公司 | A kind of for Chinese medicine synthetic treating flatulence and preparation method thereof |
| CN106266704A (en) * | 2016-09-13 | 2017-01-04 | 佛山市顺德区宝铜金属科技有限公司 | The Chinese medicine composition for the treatment of gastroenteritis and preparation method |
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