CN105287953A - Preparation with uremia treating effect and preparation method - Google Patents

Preparation with uremia treating effect and preparation method Download PDF

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Publication number
CN105287953A
CN105287953A CN201510714761.8A CN201510714761A CN105287953A CN 105287953 A CN105287953 A CN 105287953A CN 201510714761 A CN201510714761 A CN 201510714761A CN 105287953 A CN105287953 A CN 105287953A
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radix
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不公告发明人
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张相才
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Abstract

The invention discloses a preparation with a uremia treating effect. The preparation is mainly prepared from, by mass, 7-12 parts of roots of red-rooted salvia, 9-14 parts of herb of gold stargrass, 6-13 parts of smallfruit fig aerial roots, 4-7 parts of orange flowers, 8-13 parts of angelica sinensis, 7-14 parts of selaginella nipponica sav, 5-10 parts of roses, 9-13 parts of peruvian groundcherry herb, 6-10 parts of prinsepia utilis royle, 8-12 parts of radix paeoniae alba, 10-14 parts of ziziphora clinopodioides lam, 9-15 parts of ramose scouring rush herb, 7-13 parts of polygonum multiflorum and 6-12 parts of devilpepper. The preparation is prepared through clinical practice of many years, has the effects of promoting blood circulation to arrest pain, detoxicating and being diuretic, and is remarkable in treatment effect.

Description

A kind of have the preparation and method for making of curing uremia's effect
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation and the method for making with treatment uremia effect.
Background technology
Uremia, for the latter stage of chronic renal failure is generally called.Chronic renal failure (CRF) Shi Cheng uremia is not one independently disease, being that the various cause of disease causes kidney damage and Progressive symmetric erythrokeratodermia deterioration, when developing into whole latter stage, when renal function is close to normal 10%-15%, occurring a series of Comprehensive Clinical symptom.Etiological has primary glomerulonephritis, chronic pyelonephritis, hypertensive renal arteriolar sclerosis, diabetic nephropathy, secondary glomerulonephritis, interstitial disease of renal tubule, heritability kidney to suffer from uremic symptom main manifestations: skin pruritus, hemopoietic system performance anemia, tired, dizzy, headache, hypomnesis, lethargy, anorexia can be there is, the phenomenon such as Nausea and vomiting or diarrhoea during aggravation.
Publication No. CN104606440A(application number 201510081553.9) Chinese patent literature disclose one and treat uremic Chinese medicine, its active component is prepared from by the raw material of following weight proportion: Radix Rehmanniae 24-25g, Rhizoma Atractylodis Macrocephalae 12-15g, cattle sunset 15-20g, Radix Paeoniae Alba 15-20g, Semen Plantaginis 20g, Poria 15g, Rhizoma Alismatis 0-15g, Cortex Eucommiae 0-30g, Fructus Psoraleae 0-24g, Fructus Lycii 0-20g, Semen Platycladi 0-25g, Rhizoma dioscoreae 0-15g, Radix Panacis Quinquefolii 0-30g, Cortex Moutan 0-20g, Semen Cuscutae 0-18g, Radix Angelicae Sinensis 0-25g, Radix Codonopsis 0-15g, Rhizoma Cyperi 0-15g, Rhizoma Anemarrhenae 0-15g, Rhizoma Chuanxiong 0-12g, Radix Dipsaci 0-15g, Rhizoma Zingiberis Recens 0-10g, Radix Glycyrrhizae 0-3g, Fructus Chaenomelis 0-20g, Folium Perillae 0-15g, Pericarpium Citri Reticulatae 0-15g.Publication No. CN104189116A(application number 201410496449.1) Chinese patent literature disclose one and treat uremic Chinese medicine formula, one treats uremic Chinese medicine formula, it is characterized in that: this formula by quality proportioning is: Poria 18-22 part, Cortex Moutan 8-12 part, Cortex Cinnamomi 22-28 part, Herba Dianthi 12-17 part, decoction, unguentum, spray, the concentrated dosage form such as sheet, ball can be made by the powder of this composition.Publication No. CN103933189A(application number 201310019969.9) Chinese patent literature disclose one and treat uremic Chinese medicine preparation, technical scheme: Radix Panacis Quinquefolii 20 parts, Folium Sennae 20 parts, Polyporus 20 parts, Herba Houttuyniae (fresh herb) 30 parts, 4 parts, Flos Carthami, 6 parts, Radix Glycyrrhizae, Herba Houttuyniae is put in multi-function extractor and extracts volatile oil, collect volatile oil for subsequent use; Add Folium Sennae, Radix Glycyrrhizae and the active ingredient of Herba Houttuyniae medicinal residues extracting in water water solublity, extracting solution is condensed into extractum; Radix Panacis Quinquefolii, Polyporus (abandoning skin), Flos Carthami are broken into the adjuvant such as fine powder and above-mentioned medical material extractum, volatile oil and appropriate dextrin and be mixed and made into the form of Chinese drug such as capsule or solid pill, subpackage and get final product.
It is main for being used for the treatment of uremic medicine at present mainly with Western medicine, and be aided with dialysis, some drugs can only alleviate disease, can not reach the effect for the treatment of both the principal and secondary aspects of a disease, and spend high, patient economy burden is large, for the Chinese medicine formula providing a kind of curative effect reliable, cheap, need strengthen research in this respect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the wide preparation with treatment uremia effect of safe and applicable and method for making.
Technical scheme of the present invention is:
There is a preparation of curing uremia's effect, be prepared from primarily of following bulk drugs, be mass parts: Radix Salviae Miltiorrhizae 7-12; Herba hypoxis aureae 9-14; Radix Aerio Fici Microcarpae 6-13; Citrus aurantium L. var. amara Engl. 4-7; Radix Angelicae Sinensis 8-13; Little Sabina procumbens 7-14; Flos Rosae Rugosae 5-10; Fructus Seu Herba Pubescentis 9-13; Folium Prinsepiae Utilis 6-10; Radix Paeoniae Alba 8-12; Lip Rhizoma et radix valerianae 10-14; Herba equiseti ramosissimi 9-15; Radix Polygoni Multiflori 7-13; Radix Rauvolfiae 6-12.
Preferred version is, Radix Salviae Miltiorrhizae 9-10; Herba hypoxis aureae 11-12; Radix Aerio Fici Microcarpae 8-11; Citrus aurantium L. var. amara Engl. 5-6; Radix Angelicae Sinensis 10-11; Little Sabina procumbens 9-12; Flos Rosae Rugosae 6-9; Fructus Seu Herba Pubescentis 10-12; Folium Prinsepiae Utilis 7-9; Radix Paeoniae Alba 9-11; Lip Rhizoma et radix valerianae 11-13; Herba equiseti ramosissimi 10-14; Radix Polygoni Multiflori 9-11; Radix Rauvolfiae 8-10.
More preferably, Radix Salviae Miltiorrhizae 9.5; Herba hypoxis aureae 11.5; Radix Aerio Fici Microcarpae 9.5; Citrus aurantium L. var. amara Engl. 5.5; Radix Angelicae Sinensis 10.5; Little Sabina procumbens 10.5; Flos Rosae Rugosae 7.5; Fructus Seu Herba Pubescentis 11; Folium Prinsepiae Utilis 8; The Radix Paeoniae Alba 10; Lip Rhizoma et radix valerianae 12; Herba equiseti ramosissimi 12; Radix Polygoni Multiflori 10; Radix Rauvolfiae 9.
The preparation method of described preparation pill, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) step (1) (2) (3) made crude drug is pulverized and sieved, make medicated powder, add water and generally make ball, cold drying, sterilization packaging, obtain pill.
The preparation method of described preparation pill, it is (preferred: to pulverize 70-90 mesh sieve that step (4) pulverized 60-100 mesh sieve; Be more preferably: pulverized 80 mesh sieves).
The preparation method of described preparation granules agent, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, is placed in marmite, decocts with water to boiling, turns little fire and continues heating 16-24 minute (preferably: little fire continues heating 18-22 minute; Be more preferably: little fire continues heating 20 minutes), collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate, drying and crushing, add cane sugar powder mixing, make graininess, obtain granule.
The preparation method of described preparation granules agent, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
The preparation method of described preparation decoction, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, is placed in marmite, decocts with water to boiling, turns little fire and continues heating 16-24 minute (preferably: little fire continues heating 18-22 minute; Be more preferably: little fire continues heating 20 minutes), collecting by filtration filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, add water and again decoct 15 minutes, after filtration, merge twice gained filtrate, heating is concentrated into 1/3 of original volume, obtains decoction.
The preparation method of described preparation decoction, the 7-9 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 7.5-8.5 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 8 times of boiled crude drug quality).
The preparation method of described formulation tablet, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, be placed in marmite, adding boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct to seething with excitement, turning little fire and continuing heating 16-24 minute (preferably: little fire continues heating 18-22 minute; Be more preferably: little fire continues heating 20 minutes), collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, pulverizes and sieves dry thing, makes medicated powder, adds adjuvant and mixes thoroughly, is crushed to oval tablet dosage form, obtains tablet.
The preparation method of described formulation tablet, it is (preferred: to pulverize 100-120 mesh sieve that step (5) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
A kind of pharmaceutical formulation science with treatment uremia effect provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and safety has no side effect, applied widely;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of promoting blood circulation and stopping pain, removing toxic substances diuresis;
3, Chinese crude drug selected by the present invention, wide material sources, cheap, do not increase patient economy burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1there is a preparation of curing uremia's effect, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Salviae Miltiorrhizae 7 parts, Herba hypoxis aureae 9 parts, Radix Aerio Fici Microcarpae 6 parts, Citrus aurantium L. var. amara Engl. 4 parts, Radix Angelicae Sinensis 8 parts, little Sabina procumbens 7 parts, Flos Rosae Rugosae 5 parts, Fructus Seu Herba Pubescentis 9 parts, Folium Prinsepiae Utilis 6 parts, the Radix Paeoniae Alba 8 parts, lip Rhizoma et radix valerianae 10 parts, Herba equiseti ramosissimi 9 parts, Radix Polygoni Multiflori 7 parts, Radix Rauvolfiae 6 parts.Above-mentioned a kind of preparation method with the preparation pill of curing uremia's effect is:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 21 minutes, take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 13 minutes with vinegar water (ratio of vinegar and water is 1:4), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, infiltrates 40 minutes, takes out, puts into frying pan, drenches into rice vinegar and fries to dry, taking out;
(4) step (1) (2) (3) made crude drug was pulverized 80 mesh sieves, made medicated powder, and added water and generally make ball, cold drying, sterilization packaging, obtain pill.
embodiment 2there is a preparation of curing uremia's effect, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Salviae Miltiorrhizae 12 parts, Herba hypoxis aureae 14 parts, Radix Aerio Fici Microcarpae 13 parts, Citrus aurantium L. var. amara Engl. 7 parts, Radix Angelicae Sinensis 13 parts, little Sabina procumbens 14 parts, Flos Rosae Rugosae 10 parts, Fructus Seu Herba Pubescentis 13 parts, Folium Prinsepiae Utilis 10 parts, the Radix Paeoniae Alba 12 parts, lip Rhizoma et radix valerianae 14 parts, Herba equiseti ramosissimi 15 parts, Radix Polygoni Multiflori 13 parts, Radix Rauvolfiae 12 parts.Above-mentioned a kind of preparation method with the preparation granules agent of curing uremia's effect is:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 21 minutes, take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 13 minutes with vinegar water (ratio of vinegar and water is 1:4), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, infiltrates 40 minutes, takes out, puts into frying pan, drenches into rice vinegar and fries to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, is placed in marmite, and the soak by water adding boiled crude drug quality 6.5 times, to boiling, turns little fire and continues heating 20 minutes, collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate, drying and crushing, add cane sugar powder mixing, make graininess, obtain granule.
Model case: xxx, male, 58 years old.Main suit: stomachache is felt sick, hydrosarca, and urine volume is few; Medical history: patient checks out to suffer from acute nephritis the year before, once by medication treatment, suddenly there is feel sick stomachache, dysuria in the recent period, general weakness, the symptom of spirit difference, removes examination in hospital then, urine protein (+++), creatinine 869.3umol/L, blood urea nitrogen 69.65mmol/L, be diagnosed as chronic nephritis and uremia.
Take this example gained granule, each 6-10g, warm boiled water, one day twice 15 days is a course for the treatment of, after patient takes a course for the treatment of, the each index of health declines all to some extent, and uncomfortable disease alleviates gradually, after adhering to taking four courses for the treatment of, the all diseases of patient disappear entirely, body constitution strengthens, and checks each index and all recovers normal, and patient fully recovers, follow up a case by regular visits to after 1 year, the state of an illness is without recurrence.
embodiment 3there is a preparation of curing uremia's effect, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Salviae Miltiorrhizae 9 parts, Herba hypoxis aureae 11 parts, Radix Aerio Fici Microcarpae 8 parts, Citrus aurantium L. var. amara Engl. 5 parts, Radix Angelicae Sinensis 10 parts, little Sabina procumbens 9 parts, Flos Rosae Rugosae 6 parts, Fructus Seu Herba Pubescentis 10 parts, Folium Prinsepiae Utilis 7 parts, the Radix Paeoniae Alba 9 parts, lip Rhizoma et radix valerianae 11 parts, Herba equiseti ramosissimi 10 parts, Radix Polygoni Multiflori 9 parts, Radix Rauvolfiae 8 parts.Above-mentioned a kind of preparation method with the preparation decoction of curing uremia's effect is:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 21 minutes, take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 13 minutes with vinegar water (ratio of vinegar and water is 1:4)), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, infiltrates 40 minutes, takes out, puts into frying pan, drenches into rice vinegar and fries to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, is placed in marmite, and the soak by water adding boiled crude drug quality 8 times is to boiling, and turn little fire and continue heating 20 minutes, collecting by filtration filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, add water and again decoct 15 minutes, after filtration, merge twice gained filtrate, heating is concentrated into 1/3 of original volume, obtains decoction.
Model case: xxx, women, 35 years old.Medical history: patient has uremia half a year, and all the time by taking medicine and maintenance of dialysing, body constitution is poor, inappetence, and weak sleepy, stature is become thin, lassitude, effect of taking medicine is remarkable, bears medical expenses, then select treatment by Chinese herbs because of unable.
Recommend to take this example gained decoction, each 200-250ml through people, warmly to take, one day twice 15 days is a course for the treatment of, after patient takes a course for the treatment of, symptom is obviously improved, and adheres to taking three courses for the treatment of, and patient mental takes a turn for the better, muscle power strengthens, after continuing to take two courses for the treatment of, patient experiences stable disease, indices closes on normal range substantially, follow up a case by regular visits in 1 year, patient recovers orthobiosis.
embodiment 4there is a preparation of curing uremia's effect, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Salviae Miltiorrhizae 10 parts, Herba hypoxis aureae 12 parts, Radix Aerio Fici Microcarpae 11 parts, Citrus aurantium L. var. amara Engl. 6 parts, Radix Angelicae Sinensis 11 parts, little Sabina procumbens 12 parts, Flos Rosae Rugosae 9 parts, Fructus Seu Herba Pubescentis 12 parts, Folium Prinsepiae Utilis 9 parts, the Radix Paeoniae Alba 11 parts, lip Rhizoma et radix valerianae 13 parts, Herba equiseti ramosissimi 14 parts, Radix Polygoni Multiflori 11 parts, Radix Rauvolfiae 10 parts.Above-mentioned a kind of preparation method with the formulation tablet of curing uremia's effect is:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 21 minutes, take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 13 minutes with vinegar water (ratio of vinegar and water is 1:4), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, infiltrates 40 minutes, takes out, puts into frying pan, drenches into rice vinegar and fries to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, is placed in marmite, and the soak by water adding boiled crude drug quality 6 times, to boiling, turns little fire and continues heating 20 minutes, collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, pulverized 110 mesh sieves by dry thing, made medicated powder, added adjuvant and mixed thoroughly, was crushed to oval tablet dosage form, obtained tablet.
Model case: xxx, male, 46 years old.Main suit: general weakness, edema of pair of lower extremities; Medical history: patient is wind-engaging flu two months ago, and the state of an illness does not take a turn for the better always completely, feels edema of pair of lower extremities in the recent period, general weakness, and lethargy arrives examination in hospital then, blood urea nitrogen 78.63mmol/L, and serum creatinine 596.4umol/L, is diagnosed as uremia.
Take this example gained tablet, each 2-3 sheet, warm boiled water, one day twice 15 days is a course for the treatment of, after patient takes a course for the treatment of, edema symptom alleviates to some extent, and after adhering to taking two courses for the treatment of, the uncomfortable disease of patient is eliminated substantially, spirit takes a turn for the better, consolidate a course for the treatment of, check each index and recover normal, patient fully recovers, follow up a case by regular visits in half a year, do not recur again.
embodiment 5there is a preparation of curing uremia's effect, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Salviae Miltiorrhizae 9.5 parts, Herba hypoxis aureae 11.5 parts, Radix Aerio Fici Microcarpae 9.5 parts, Citrus aurantium L. var. amara Engl. 5.5 parts, Radix Angelicae Sinensis 10.5 parts, little Sabina procumbens 10.5 parts, Flos Rosae Rugosae 7.5 parts, Fructus Seu Herba Pubescentis 11 parts, Folium Prinsepiae Utilis 8 parts, the Radix Paeoniae Alba 10 parts, lip Rhizoma et radix valerianae 12 parts, Herba equiseti ramosissimi 12 parts, Radix Polygoni Multiflori 10 parts, Radix Rauvolfiae 9 parts.Above-mentioned a kind of preparation method with the preparation pill of curing uremia's effect is:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 21 minutes, take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 13 minutes with vinegar water (ratio of vinegar and water is 1:4), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, infiltrates 40 minutes, takes out, puts into frying pan, drenches into rice vinegar and fries to dry, taking out;
(4) step (1) (2) (3) made crude drug was pulverized 80 mesh sieves, made medicated powder, and added water and generally make ball, cold drying, sterilization packaging, obtain pill.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Salviae Miltiorrhizae: base is former: be the root of labiate Radix Salviae Miltiorrhizae and Salvia przewalskii.Nature and flavor: bitter in the mouth; Cold nature.Gui Jing: GUIXIN; Pericardium; Liver Channel.Function cures mainly: blood circulation promoting and blood stasis dispelling; Menstruction regulating and pain relieving; Nourishing blood to tranquillize the mind; Removing heat from blood eliminating carbuncle.Main menoxenia; Dysmenorrhea; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Trusted subordinate's pain; Lump in the abdomen; Pyretic arthralgia swells and ache; Traumatic injury; Heat enters nutrient blood; Dysphoria; Vexed insomnia; Carbuncle pyogenic infections from tumour or sore.
Herba hypoxis aureae: base is former: be the Herb of bloodwort Herba hypoxis aureae.Nature and flavor: sweet, micro-pungent, warm.Function cures mainly: warming the kidney to invigorate YANG; Regulating QI to relieve pain.Main lumbago due to renal deficiency; Sexual impotence; Insomnia; Colic of cold type is suffered from abdominal pain.
Radix Aerio Fici Microcarpae: base is former: be the aerial root of moraceae plants Ficus microcarpa Linn. f.Nature and flavor: bitter in the mouth, property are flat.Gui Jing: lung; Spleen; Kidney channel.Function cures mainly: loose wind heat; Wind-damp dispelling; Promoting blood circulation and stopping pain.Main flow sense; Pertussis; Measles without adequate eruption; Tonsillitis; Conjunctivitis; Rheumatic ostalgia; Eruptive disease is suffered from abdominal pain; Chronic dysentery; Stomachache; Leucorrhea; Eczema; Pudendal pruritus; Traumatic injury.
Citrus aurantium L. var. amara Engl.: base is former: be the alabastrum of rutaceae Citrus aurantium L. var. amara Engl..Nature and flavor: pungent; Sweet; Micro-hardship; Property is put down.Function cures mainly: the chest stuffiness relieving of regulating the flow of vital energy; Stomach function regulating preventing or arresting vomiting.It is main that painful abdominal mass is vexed in the heart; Abdominal distention; Anorexia; Nausea and vomiting.
Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
Little Sabina procumbens: base is former: for Selaginaceae Rock lily plant is thrown oneself on the ground the herb of Herba Selaginellae.The property of medicine: micro-hardship, cool.Function cures mainly: cough-relieving, relievings asthma, heat clearing away, hemostasis.Cure mainly cough and asthma, spit blood, hemorrhoidal bleeding, traumatic hemorrhage, stranguria, burn and scald.
Flos Rosae Rugosae: nature and flavor: sweet; Micro-hardship; Temperature; Nontoxic.Gui Jing: liver; Spleen channel.Function cures mainly: resolving depression of regulating the flow of vital energy; Regulating menstruation by adjusting the flow of blood.Chest and diaphragm caused by main depression of liver-QI is full vexed, and gastral cavity side of body distending pain, breast is done swollen, menoxenia, and dysentery is had loose bowels, leukorrhagia, traumatic injury carbuncle.
Fructus Seu Herba Pubescentis: base is former: be the Herb of eggplant kind of plant Fructus Seu Herba Pubescentis.Nature and flavor: bitter in the mouth; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing.Main flu; Laryngalgia; Cough; Mumps; It suburb skin ulcer.
Folium Prinsepiae Utilis: base is former: be the leaf of rosaceous plant Folium Prinsepiae Utilis.Nature and flavor: bitter; Pungent; Cold.Gui Jing: the heart; Liver; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation.Main acute mastitis, mumps, hemorrhoid, scrofula, traumatic injury, menoxenia.
The Radix Paeoniae Alba: base is former: be the root of ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor with return through, bitter, sour, be slightly cold.Return liver, spleen channel.There is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, stabilize effect of sun.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Lip Rhizoma et radix valerianae: base is former: be the Herb of labiate lip Rhizoma et radix valerianae.Nature and flavor: oil is pungent; Cool in nature.Function cures mainly: mind tranquilizing and the heart calming; Diuretic heat clearing away.Main cardiopalmus; Insomnia; Edema; Cold, fever; Conjunctival congestion and swelling pain; Sore swollen toxin.
Herba equiseti ramosissimi: base is former: be the herb of Equisetaceae plant Herba Clinopodii Polycephali.Chemical analysis: herb contains nicotine, equisetine, Kaempferol-sophoroside-7-glycoside, Kaempferol-sophoroside, sitosterol, stigmasterol.Nature and flavor: sweet; Bitter; Flat; Nontoxic; Be slightly cold.Gui Jing: the heart; Liver; Stomach; Urinary bladder channel.Function cures mainly: liver heat removing and eyesight improving; Hemostasis; Inducing diuresis for treating stranguria syndrome; Main anemopyretic cold; Cough; Conjunctival congestion and swelling pain; Nebula; Epistaxis; Hematuria; Discharging fresh blood stool; Stranguria; Jaundice; Leukorrhagia; Fracture.
Radix Polygoni Multiflori: nature and flavor with return through: bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.There is removing toxic substances, eliminating carbuncle, preventing the attack (or recurrence) of malaria, effect of loosening bowel to relieve constipation.For carbuncle sore, scrofula, rubella pruritus, chronic malaria body is empty, dryness of the intestine constipation.
Radix Rauvolfiae: base is former: be the root of apocynaceae plant Radix Rauvolfiae.Nature and flavor: bitter; Micro-pungent; Cool in nature.Function cures mainly: heat clearing away; Blood pressure lowering; Allay excitement.Main cold, fever; Headache body pain; Laryngopharynx swelling and pain; Hypertension; Dizzy; Insomnia.
test example 1a kind of clinical practice with the preparation (embodiment 5) of curing uremia's effect of gained of the present invention:
Choose crowd: in April ,-2015 in June, 2014, according to medical case history, four hospital's Screening Diagnosis be uremic patient 304 example, age 11-67 year, 39.5 ± 1.5 years old mean age, the course of disease 2 months-6 years, wherein male patient 168 example, female patient 136 example, diagnosis Main Basis clinical manifestation and blood bio-chemistry checking (serum creatinine > 442umol/L, blood urea nitrogen > 21.42mmol/L), Chinese medical discrimination, carries out dialectical with reference to " obstruction and rejection ", " difficulty in urination ", " exhaustion of kidney-QI " etc.
Before test, patient is divided into two groups at random, experimental group 180 example and matched group 124 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes products obtained therefrom of the present invention, each 2-3 grain, one day twice, warm boiled water, within 15 days, is a course for the treatment of; Matched group takes other conventional medicines (Caps Bailing, NIAODUQING KELI, Metoclopramide Tablets etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: clinical symptoms is all eliminated, and blood urea nitrogen and serum creatinine recover normal; (2) effective: clinical symptom relief or disappearance, blood urea nitrogen and serum creatinine decline >=30%; (3) effective: clinical symptoms makes moderate progress, blood urea nitrogen and serum creatinine decline >=20%; (4) stable: clinical symptoms is without improvement or increase the weight of, and blood urea nitrogen and serum creatinine are substantially unchanged.Total effective rate=cure rate+obvious effective rate+effective percentage
Clinical effectiveness: after the taking medicine of three courses for the treatment of, the therapeutic outcome of two groups is as follows:
The healing patient of experimental group is 121 examples, and cure rate is 67.2%, and effective patient is 37 examples, and obvious effective rate is 20.6%, and effective patient is 17 examples, and effective percentage is 9.4%, and total effective rate is 97.2%;
The patient that matched group is cured is 66 examples, and cure rate is 53.2%, and effective patient is 24 examples, and obvious effective rate is 19.4%, effective patient is 11 examples, and effective percentage is 8.9%, total effective rate 81.5%, be starkly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.Occur 1 untoward reaction example during experimental group patient treatment, there are 10 untoward reaction examples in matched group patient, after drug withdrawal, health all recovers normal, illustrates that gained safety of medicine of the present invention has no side effect, can relievedly take.
The Chinese medicine synergism used in the present invention, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, Herba hypoxis aureae warming the kidney to invigorate YANG, Radix Aerio Fici Microcarpae promoting blood circulation and stopping pain, Citrus aurantium L. var. amara Engl. is regulated the flow of vital energy the chest stuffiness relieving, and Chinese angelica blood supplementing is invigorated blood circulation, little Sabina procumbens clearing away heat to stop bleeding, Flos Rosae Rugosae is regulated the flow of vital energy resolving depression, Fructus Seu Herba Pubescentis heat-clearing and toxic substances removing, Folium Prinsepiae Utilis blood circulation promoting and dispersing pathogen accumulation, Radix Paeoniae Alba nourishing blood for regulating menstruation, the heat clearing away of lip Rhizoma et radix valerianae diuretic, Herba equiseti ramosissimi inducing diuresis for treating stranguria syndrome, Radix Polygoni Multiflori removing toxicity for eliminating carbuncles, Radix Rauvolfiae heat clearing away is allayed excitement, and plays effect of promoting blood circulation and stopping pain, removing toxic substances diuresis altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. there is a preparation of curing uremia's effect, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Salviae Miltiorrhizae 7-12; Herba hypoxis aureae 9-14; Radix Aerio Fici Microcarpae 6-13; Citrus aurantium L. var. amara Engl. 4-7; Radix Angelicae Sinensis 8-13; Little Sabina procumbens 7-14; Flos Rosae Rugosae 5-10; Fructus Seu Herba Pubescentis 9-13; Folium Prinsepiae Utilis 6-10; Radix Paeoniae Alba 8-12; Lip Rhizoma et radix valerianae 10-14; Herba equiseti ramosissimi 9-15; Radix Polygoni Multiflori 7-13; Radix Rauvolfiae 6-12.
2. a kind of as claimed in claim 1 have the preparation of curing uremia's effect, it is characterized in that, Radix Salviae Miltiorrhizae 9-10; Herba hypoxis aureae 11-12; Radix Aerio Fici Microcarpae 8-11; Citrus aurantium L. var. amara Engl. 5-6; Radix Angelicae Sinensis 10-11; Little Sabina procumbens 9-12; Flos Rosae Rugosae 6-9; Fructus Seu Herba Pubescentis 10-12; Folium Prinsepiae Utilis 7-9; Radix Paeoniae Alba 9-11; Lip Rhizoma et radix valerianae 11-13; Herba equiseti ramosissimi 10-14; Radix Polygoni Multiflori 9-11; Radix Rauvolfiae 8-10(is preferably: Radix Salviae Miltiorrhizae 9.5; Herba hypoxis aureae 11.5; Radix Aerio Fici Microcarpae 9.5; Citrus aurantium L. var. amara Engl. 5.5; Radix Angelicae Sinensis 10.5; Little Sabina procumbens 10.5; Flos Rosae Rugosae 7.5; Fructus Seu Herba Pubescentis 11; Folium Prinsepiae Utilis 8; The Radix Paeoniae Alba 10; Lip Rhizoma et radix valerianae 12; Herba equiseti ramosissimi 12; Radix Polygoni Multiflori 10; Radix Rauvolfiae 9).
3. the preparation method of the preparation pill as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) pulverized and sieved by step (1) (2) (3) made crude drug, make medicated powder, add water and generally make ball, low temperature is irritated, and sterilization packaging, obtains pill.
4. the preparation method of preparation pill as claimed in claim 3, is characterized in that, it is (preferred: to pulverize 70-90 mesh sieve that step (4) pulverized 60-100 mesh sieve; Be more preferably: pulverized 80 mesh sieves).
5. the preparation method of the preparation granules agent as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, is placed in marmite, decocts with water to boiling, turns little fire and continues heating 16-24 minute (preferably: little fire continues heating 18-22 minute; Be more preferably: little fire continues heating 20 minutes), collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate, drying and crushing, add cane sugar powder mixing, make graininess, obtain granule.
6. the preparation method of preparation granules agent as claimed in claim 5, is characterized in that, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
7. the preparation method of the preparation decoction as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, is placed in marmite, decocts with water to boiling, turns little fire and continues heating 16-24 minute (preferably: little fire continues heating 18-22 minute; Be more preferably: little fire continues heating 20 minutes), collecting by filtration filtrate, filtering residue is stand-by;
(5) by step (4) remaining filtering residue, add water and again decoct 15 minutes, after filtration, merge twice gained filtrate, heating is concentrated into 1/3 of original volume, obtains decoction.
8. the preparation method of preparation decoction as claimed in claim 7, is characterized in that, the 7-9 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 7.5-8.5 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 8 times of boiled crude drug quality).
9. the preparation method of the formulation tablet as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Citrus aurantium L. var. amara Engl., Flos Rosae Rugosae and Folium Prinsepiae Utilis and clean chopping, be placed in saline and soak 16-26 minute (preferably: saline soaks 19-23 minute; Be more preferably: soak 21 minutes in saline), take out, put into frying pan, moderate heat is heated to drying, and drench and mix moistening thoroughly 5 minutes into rice vinegar, taking-up cools;
(2) by Radix Salviae Miltiorrhizae, Radix Aerio Fici Microcarpae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Polygoni Multiflori and Radix Rauvolfiae removing impurity, be placed in steamer, steam 8-18 minute (preferably: steam 10-16 minute with vinegar water (ratio of vinegar and water is 1:4); Be more preferably: steam 13 minutes), take out, cut sheet, admix Sal, slow fire stir-fries to drying, and taking-up cools;
(3) Herba hypoxis aureae, little Sabina procumbens, Fructus Seu Herba Pubescentis, lip Rhizoma et radix valerianae and Herba equiseti ramosissimi wash quickly is clean, the hydromel adding crude drug quality 0.5 times is mixed thoroughly, and it is (preferred: to infiltrate 35-45 minute to infiltrate 30-50 minute; Be more preferably: infiltrate 40 minutes), take out, put into frying pan, drench into rice vinegar and fry to dry, taking out;
(4) blend step (1) (2) (3) made crude drug, be placed in marmite, adding boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) to decoct to seething with excitement, turning little fire and continuing heating 16-24 minute (preferably: little fire continues heating 18-22 minute; Be more preferably: little fire continues heating 20 minutes), collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, pulverizes and sieves dry thing, makes medicated powder, adds adjuvant and mixes thoroughly, is crushed to oval tablet dosage form, obtains tablet.
10. the preparation method of formulation tablet as claimed in claim 9, is characterized in that, it is (preferred: to pulverize 100-120 mesh sieve that step (5) pulverized 80-140 mesh sieve; Be more preferably: pulverized 110 mesh sieves).
CN201510714761.8A 2015-10-29 2015-10-29 Preparation with uremia treating effect and preparation method Pending CN105287953A (en)

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Publication number Priority date Publication date Assignee Title
CN109907145A (en) * 2019-04-24 2019-06-21 湖南省定生保健品经营有限公司 The preparation method and application of tea therapy drink

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Publication number Priority date Publication date Assignee Title
CN102430015A (en) * 2011-12-13 2012-05-02 朱友文 Traditional Chinese medicinal preparation for treating nephritis and uremia as well as preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102430015A (en) * 2011-12-13 2012-05-02 朱友文 Traditional Chinese medicinal preparation for treating nephritis and uremia as well as preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109907145A (en) * 2019-04-24 2019-06-21 湖南省定生保健品经营有限公司 The preparation method and application of tea therapy drink

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