CN102552527A - Traditional Chinese medicine composition used for treating diabetic complications and reducing blood sugar - Google Patents
Traditional Chinese medicine composition used for treating diabetic complications and reducing blood sugar Download PDFInfo
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- CN102552527A CN102552527A CN2012100224893A CN201210022489A CN102552527A CN 102552527 A CN102552527 A CN 102552527A CN 2012100224893 A CN2012100224893 A CN 2012100224893A CN 201210022489 A CN201210022489 A CN 201210022489A CN 102552527 A CN102552527 A CN 102552527A
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Abstract
The invention discloses a traditional Chinese medicine composition used for treating diabetic complications and reducing blood sugar. The composition comprises a formula A composed of an extract of Huidouba, an extract of euonymus alatus, an extract of balsam pear, an extract of Radix Puerariae, an extract of Sophora alopecuroide and Ganoderma broken-down wall spore powder, or comprises the formula A and a formula B which is composed of an extract of haw, an extract of banksia rose, an extract of Radix Astragali, an extract of ginseng leaves, an extract of Radix Puerariae, an extract of mulberry leaves, an extract of bighead atractylodes rhizome, an extract of Chinese angelica, an extract of Ligusticum wallichii, an extract of caulis polygoni multiflori, an extract of eucommia leaves, an extract of raw rehmannia root, an extract of epimeddium and chitosan oligosaccharide. Furthermore, the invention also provides a preparation method for the composition. The traditional Chinese medicine composition can effectively treat the complications of insomnia, gastrointestinal disorder, lower limb gangrene, ulcer, necrosis and erosion, limb numbness and pruritus, blurred vision, oral ulcer and the like caused by diabetes and can effectively reduce blood sugar.
Description
Technical field
What the present invention relates to is a kind of medicine of treating diabetic complication, is meant that specifically a kind of Chinese herbal medicine that uses is medicine of raw material treatment diabetic complication and blood sugar lowering and preparation method thereof.
Background technology
Diabetic complication is a kind of common chronic complicating diseases, is that it is quite serious that its consequence of back takes place by the pathological changes transformation of diabetes.Common diabetic complication has insomnia, and disorderly, the big dry stool of gastrointestinal function is rare indefinite, lower limb gangrene, ulcer, downright bad rotten to the corn, and the numb pruritus of extremity, smudgy, blind, oral ulcer etc.Diabetic complication is to cause one of dead principal element of diabetics.
Show according to ADA (ADA) statistical data in 2010, the diabetics more than 3 years, the probability that develops complications is more than 46%; Diabetics more than 5 years, the probability that develops complications is more than 61%; Diabetics more than 10 years, the probability that develops complications is up to 98%.Therefore, the chronic complicating diseases of treatment diabetes should be the core and the emphasis of treatment diabetes, lay stress in the change of blood glucose, blood pressure but have traditional treating diabetes now, and diabetic complication never is controlled effectively.
Summary of the invention
The purpose of this invention is to provide a kind of insomnia that is caused by diabetes of treating, gastrointestinal function is disorderly, Chinese medicine composition that lower limb gangrene, ulcer, downright bad rotten to the corn, the numb pruritus of extremity, blurred vision, complication such as oral ulcer also can blood sugar lowering and preparation method thereof.
Realize that technical scheme of the present invention is following: the Chinese medicine composition of treatment diabetic complication and blood sugar lowering, said medicine comprises the prescription A that is made up of HUIDOUBA extract, Ramulus euonymi extract, Fructus Momordicae charantiae extract, Radix Puerariae extract, Herba Sophorae alopecuroidis extract and Sporoderm-broken Ganoderma Lucidum Spore powder.
Further, said prescription A is made up of the component of following weight portion: 3～5 parts of HUIDOUBA extracts, 4～6 parts of Ramulus euonymi extracts, 2～4 parts of Fructus Momordicae charantiae extracts, 4～6 parts of Radix Puerariae extracts, 1～3 part of Herba Sophorae alopecuroidis extract, 7～9 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
Further, said prescription A is made up of the component of following weight portion: 4 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 3 parts of Fructus Momordicae charantiae extracts, 5 parts of Radix Puerariae extracts, 2 parts of Herba Sophorae alopecuroidis extracts, 8 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
In order better to realize the present invention, said medicine also comprises prescription B composed of the following components:
Fructus Crataegi extract, Radix Aucklandiae extract, Radix Astragali extract, extract of Radix Ginseng leaf, Radix Puerariae extract, Folium Mori extract, Rhizoma Atractylodis Macrocephalae extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Caulis Polygoni Multiflori extract, Folium Eucommiae extract, Radix Rehmanniae extract, Herba Epimedii extract, oligochitosan.
Further, said prescription B is made up of the component of following weight portion:
45～55 parts of Fructus Crataegi extracts, 17～23 parts of Radix Aucklandiae extracts, 17～23 parts of Radix Astragali extracts, 4～8 parts of extract of Radix Ginseng leafs, 8～12 parts of Radix Puerariae extracts, 8～12 parts of Folium Mori extracts, 8～12 parts of Rhizoma Atractylodis Macrocephalae extracts, 3～5 parts of Radix Angelicae Sinensis extracts, 3～5 parts of Rhizoma Chuanxiong extracts, 8～12 parts of Caulis Polygoni Multiflori extract, 8～12 parts of Folium Eucommiae extracts, 8～12 parts of Radix Rehmanniae extract, 4～8 parts of Herba Epimedii extracts, 8～12 parts of oligochitosans.
Further, said prescription B is made up of the component of following weight portion:
50 parts of Fructus Crataegi extracts, 20 parts of Radix Aucklandiae extracts, 20 parts of Radix Astragali extracts, 6 parts of extract of Radix Ginseng leafs, 10 parts of Radix Puerariae extracts, 10 parts of Folium Mori extracts, 10 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Angelicae Sinensis extracts, 4 parts of Rhizoma Chuanxiong extracts, 10 parts of Caulis Polygoni Multiflori extract, 10 parts of Folium Eucommiae extracts, 10 parts of Radix Rehmanniae extract, 6 parts of Herba Epimedii extracts, 10 parts of oligochitosans.
The method for preparing of the Chinese medicine composition of above-mentioned treatment diabetic complication and blood sugar lowering may further comprise the steps:
(1) the preparation process of prescription A: by weight mix homogeneously, general ball is processed the ball shape with each component among the prescription A;
(2) with each component among the prescription B by weight mix homogeneously, be in harmonious proportion refining with 50 degree jowar wines, process ball shape or granule.
The present invention has the following advantages and beneficial effect:
But 1, the complication that causes by diabetes of prescription A efficacious therapy of the present invention and effect with blood sugar lowering, the complication of this treatment has: insomnia, gastrointestinal function is disorderly; Lower limb gangrene, ulcer, downright bad rotten to the corn; The numb pruritus of extremity, blurred vision, oral ulcer etc.;
2, prescription A of the present invention and prescription B are used, and not only have the effect of treatment diabetic complication, but also can better assist the blood glucose that reduces diabetics, make its hypoglycemic activity more obvious;
3, the component that prescription A is adopted among the present invention is less, and its average price is cheap relatively, is suitable for promoting;
4, production cost of the present invention is low, obvious effective rate is high, is fit to apply.
The specific embodiment
Chinese medicine is to be extracted by the pure natural medicinal plants to form, and Chinese medicine is particular about steady blood sugar lowering, improves islet secretion, regulates functions such as body immunity, to preventing diabetic complication better curative effect is arranged, and is almost nil to the injury of human body.
Be example below with the clinical experiment, the present invention is done to specify further, but embodiment of the present invention be not limited thereto.
Embodiment 1
At first, obtain the extract of various materials, extraction step is following:
The material that (1) will extract is removed impurity; Like the HUIDOUBA extract, the medicinal part of HUIDOUBA is taken out;
(2) HUIDOUBA that will remove impurity carries out pulverization process; Promptly handle, it is crushed to 20 orders through pulverizer;
(3) ratio in 1Kg HUIDOUBA and 10L water is put in it in extraction pot, refluxes 20～30 minutes, obtains extracting solution; Extracting temperature is 100 ℃;
(4) with extracting solution suction concentration tank, concentrate this extracting solution, promptly adopt the conventional method for concentration of the field of Chinese medicines under 90 ℃ of left and right sides conditions, to concentrate this extracting solution;
(5) the spray-dried HUIDOUBA extract that promptly makes of extracting solution after said the concentrating.
Ramulus euonymi extract among the prescription A, Fructus Momordicae charantiae extract, Radix Puerariae extract, Herba Sophorae alopecuroidis extract all obtain through above method.
Secondly, the Sporoderm-broken Ganoderma Lucidum Spore powder among the prescription A is pulverized; Be crushed to its fineness smaller or equal to 80 orders.Can when pulverizing, cross 80 purposes sieve here, just sifted out smaller or equal to 80 purpose components, all the other compositions are proceeded to pulverize.
At last, with 4 parts of the HUIDOUBA extracts among the prescription A, 5 parts of Ramulus euonymi extracts, 3 parts of Fructus Momordicae charantiae extracts, 5 parts of Radix Puerariae extracts, 2 parts of Herba Sophorae alopecuroidis extracts, 8 parts of mix homogeneously of Sporoderm-broken Ganoderma Lucidum Spore powder, general ball makes the pill that diameter is 4mm.
Embodiment 2
Present embodiment only is that with the difference of embodiment 1 weight portion of prescription A is different.
Wherein, 3 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 4 parts of Fructus Momordicae charantiae extracts, 4 parts of Radix Puerariae extracts, 3 parts of Herba Sophorae alopecuroidis extracts, 7 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
The instructions of taking of embodiment 1 and embodiment 2 is following:
Get the pill 5～10g that makes according to prescription A, use warm boiled water, every day three times, take more than 3 months.
The detection method of embodiment 1 and embodiment 2 is following:
Select 128 and have insomnia, gastrointestinal function is disorderly, lower limb gangrene, ulcer, downright bad rotten to the corn, the numb pruritus of extremity, blurred vision, the diabetic complication patient of complication symptoms such as oral ulcer.Product 5～the 10g that lets the patient take to make according to above embodiment, took 3 months at every day three times.Concrete consumption when taking is confirmed according to patient's situation.
Testing result is following: the obvious effective rate of treatment complication reaches 47%, and total effective rate reaches 78%.The obvious effective rate of blood sugar lowering reaches 20%, and total effective rate reaches 43%.
Embodiment 3
The difference of present embodiment and embodiment 1 only is when taking prescription A, to increase takes prescription B.
Said prescription B is made up of following substances in parts by weight: 50 parts of Fructus Crataegi extracts, 20 parts of Radix Aucklandiae extracts, 20 parts of Radix Astragali extracts, 6 parts of extract of Radix Ginseng leafs, 10 parts of Radix Puerariae extracts, 10 parts of Folium Mori extracts, 10 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Angelicae Sinensis extracts, 4 parts of Rhizoma Chuanxiong extracts, 10 parts of Caulis Polygoni Multiflori extract, 10 parts of Folium Eucommiae extracts, 10 parts of Radix Rehmanniae extract, 6 parts of Herba Epimedii extracts, 10 parts of oligochitosans.
The preparation process of prescription B is following:
The extraction step of extract is identical with the extraction step of extract among the embodiment 1 among the prescription B.Oligochitosan among the prescription B is crushed to its fineness smaller or equal to 80 orders.
Various treated material among the prescription B according to above weight portion mix homogeneously, with 50 degree jowar wines mediation refinings, is processed ball shape or granule.Process the ball shape of the every ball of 3g in the present embodiment.
Embodiment 4
Present embodiment only is that with the difference of embodiment 3 weight portion of prescription A and prescription B is different.
Prescription A: 3 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 4 parts of Fructus Momordicae charantiae extracts, 4 parts of Radix Puerariae extracts, 3 parts of Herba Sophorae alopecuroidis extracts, 7 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
Prescription B: 53 parts of Fructus Crataegi extracts, 23 parts of Radix Aucklandiae extracts, 17 parts of Radix Astragali extracts, 4 parts of extract of Radix Ginseng leafs, 9 parts of Radix Puerariae extracts, 9 parts of Folium Mori extracts, 11 parts of Rhizoma Atractylodis Macrocephalae extracts, 3 parts of Radix Angelicae Sinensis extracts, 5 parts of Rhizoma Chuanxiong extracts, 8 parts of Caulis Polygoni Multiflori extract, 9 parts of Folium Eucommiae extracts, 12 parts of Radix Rehmanniae extract, 5 parts of Herba Epimedii extracts, 11 parts of oligochitosans.
The instructions of taking of embodiment 3 and embodiment 4 is following:
3～5 of the pills of getting pill 5～10g of making according to prescription A, making according to prescription B.3～5 of pills that prescription B is made brew with eliminating cold for resuscitation water, cooperate with the prescription A of 5～10g and take, and every day three times, take more than 3 months.
The detection method of embodiment 3 and embodiment 4 is following:
Select 176 diabetic complication patients, as: have the insomnia that is caused by diabetes, gastrointestinal function is disorderly, lower limb gangrene, ulcer, downright bad rotten to the corn, the numb pruritus of extremity, blurred vision, the patient of symptoms such as oral ulcer.Make above patient take the product that makes according to the present invention.Taking dose is: the pill 5～10g that makes according to prescription A, 3～5 of the pills that makes according to prescription B.3～5 of pills that at first prescription B made are used the eliminating cold for resuscitation broken off by water flush, cook tea and drink, and the while is used with pill 5～10g that prescription A makes, and every day three times, takes 3 months.Concrete consumption when taking is confirmed according to patient's situation.
Its testing result is: the obvious effective rate of treatment complication reaches 50%, and total effective rate reaches 83%.The obvious effective rate of blood sugar lowering reaches 61%, and total effective rate reaches 92%.
Testing result according to above shows: prescription A ability efficacious therapy diabetic complication of the present invention, and have effect preferably; It can also play the effect of certain blood sugar lowering.Prescription A and prescription B are used, and have strengthened the effect of its treatment complication greatly, greatly reduce blood glucose, and diabetic complication efficacious therapy efficient is also increased greatly.
Just can realize the present invention preferably according to above embodiment, but embodiment of the present invention is not limited thereto.
Claims (7)
1. the Chinese medicine composition of treatment diabetic complication and blood sugar lowering is characterized in that said medicine comprises the prescription A that is made up of HUIDOUBA extract, Ramulus euonymi extract, Fructus Momordicae charantiae extract, Radix Puerariae extract, Herba Sophorae alopecuroidis extract and Sporoderm-broken Ganoderma Lucidum Spore powder.
2. the Chinese medicine composition of treatment diabetic complication according to claim 1 and blood sugar lowering; It is characterized in that said prescription A is made up of the component of following weight portion: 3～5 parts of HUIDOUBA extracts, 4～6 parts of Ramulus euonymi extracts, 2～4 parts of Fructus Momordicae charantiae extracts, 4～6 parts of Radix Puerariae extracts, 1～3 part of Herba Sophorae alopecuroidis extract, 7～9 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
3. the Chinese medicine composition of treatment diabetic complication according to claim 2 and blood sugar lowering; It is characterized in that said prescription A is made up of the component of following weight portion: 4 parts of HUIDOUBA extracts, 5 parts of Ramulus euonymi extracts, 3 parts of Fructus Momordicae charantiae extracts, 5 parts of Radix Puerariae extracts, 2 parts of Herba Sophorae alopecuroidis extracts, 8 parts of Sporoderm-broken Ganoderma Lucidum Spore powder.
4. according to the Chinese medicine composition of each described treatment diabetic complication of claim 1～3 and blood sugar lowering, it is characterized in that said medicine also comprises prescription B composed of the following components:
Fructus Crataegi extract, Radix Aucklandiae extract, Radix Astragali extract, extract of Radix Ginseng leaf, Radix Puerariae extract, Folium Mori extract, Rhizoma Atractylodis Macrocephalae extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Caulis Polygoni Multiflori extract, Folium Eucommiae extract, Radix Rehmanniae extract, Herba Epimedii extract, oligochitosan.
5. the Chinese medicine composition of treatment diabetic complication according to claim 4 and blood sugar lowering is characterized in that, said prescription B is made up of the component of following weight portion:
45～55 parts of Fructus Crataegi extracts, 17～23 parts of Radix Aucklandiae extracts, 17～23 parts of Radix Astragali extracts, 4～8 parts of extract of Radix Ginseng leafs, 8～12 parts of Radix Puerariae extracts, 8～12 parts of Folium Mori extracts, 8～12 parts of Rhizoma Atractylodis Macrocephalae extracts, 3～5 parts of Radix Angelicae Sinensis extracts, 3～5 parts of Rhizoma Chuanxiong extracts, 8～12 parts of Caulis Polygoni Multiflori extract, 8～12 parts of Folium Eucommiae extracts, 8～12 parts of Radix Rehmanniae extract, 4～8 parts of Herba Epimedii extracts, 8～12 parts of oligochitosans.
6. the Chinese medicine composition of treatment diabetic complication according to claim 5 and blood sugar lowering is characterized in that, said prescription B is made up of the component of following weight portion:
50 parts of Fructus Crataegi extracts, 20 parts of Radix Aucklandiae extracts, 20 parts of Radix Astragali extracts, 6 parts of extract of Radix Ginseng leafs, 10 parts of Radix Puerariae extracts, 10 parts of Folium Mori extracts, 10 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Angelicae Sinensis extracts, 4 parts of Rhizoma Chuanxiong extracts, 10 parts of Caulis Polygoni Multiflori extract, 10 parts of Folium Eucommiae extracts, 10 parts of Radix Rehmanniae extract, 6 parts of Herba Epimedii extracts, 10 parts of oligochitosans.
7. the method for preparing of the Chinese medicine composition of any described treatment diabetic complication of claim 1～6 and blood sugar lowering is characterized in that, may further comprise the steps:
(1) the preparation process of prescription A: by weight mix homogeneously, general ball is processed the ball shape with each component among the prescription A;
(2) with each component among the prescription B by weight mix homogeneously, be in harmonious proportion refining with 50 degree jowar wines, process ball shape or granule.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103283840A (en) * | 2013-04-23 | 2013-09-11 | 蚌埠市福淋乳业有限公司 | Balsam pear fermented mung bean milk with hypoglycemic effect |
| CN104172166A (en) * | 2014-08-18 | 2014-12-03 | 周玉梅 | Healthcare porridge applicable to postpartum type-II diabetics and preparation method of healthcare porridge |
| CN104187681A (en) * | 2014-09-18 | 2014-12-10 | 云南省农业科学院高山经济植物研究所 | Hypoglycemic and hypolipidemic health food and preparation method thereof |
| CN107510836A (en) * | 2017-09-15 | 2017-12-26 | 李玉保 | A kind of bitter gourd polypeptide pharmaceutical composition for treating diabetic ulcer and preparation method thereof |
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| CN1565617A (en) * | 2003-06-12 | 2005-01-19 | 刘会生 | Nutrient healthy powder for decreasing blood sugar and resolving stagnation |
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| CN101357156A (en) * | 2008-09-09 | 2009-02-04 | 田淑琴 | Traditional Chinese medicine for curing diabetes and preparation method thereof |
| CN101380339A (en) * | 2008-10-17 | 2009-03-11 | 扬州大学 | Extraction method of Heidouba effective constituent |
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| WO1998019688A1 (en) * | 1996-11-01 | 1998-05-14 | Sam Chun Dang Pharm. Co., Ltd. | Pharmaceutical composition for treatment of diabetes |
| CN1565617A (en) * | 2003-06-12 | 2005-01-19 | 刘会生 | Nutrient healthy powder for decreasing blood sugar and resolving stagnation |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103283840A (en) * | 2013-04-23 | 2013-09-11 | 蚌埠市福淋乳业有限公司 | Balsam pear fermented mung bean milk with hypoglycemic effect |
| CN104172166A (en) * | 2014-08-18 | 2014-12-03 | 周玉梅 | Healthcare porridge applicable to postpartum type-II diabetics and preparation method of healthcare porridge |
| CN104172166B (en) * | 2014-08-18 | 2016-06-08 | 陈斌武 | A kind of health care congee suitable in type ��diabetes mellitus people puerperal and preparation method thereof |
| CN104187681A (en) * | 2014-09-18 | 2014-12-10 | 云南省农业科学院高山经济植物研究所 | Hypoglycemic and hypolipidemic health food and preparation method thereof |
| CN104187681B (en) * | 2014-09-18 | 2016-08-24 | 云南省农业科学院高山经济植物研究所 | A kind of reducing blood sugar and blood fat health food and preparation method thereof |
| CN107510836A (en) * | 2017-09-15 | 2017-12-26 | 李玉保 | A kind of bitter gourd polypeptide pharmaceutical composition for treating diabetic ulcer and preparation method thereof |
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| CN102552527B (en) | 2013-09-25 |
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Address after: 614200 processing and warehousing logistics park, Hongxing Industrial Zone, victory Town, Mount Emei, Leshan, Sichuan Patentee after: Mount Emei Hong Noboru medicine company limited-liability company Address before: 614200 processing and warehousing logistics park, Hongxing Industrial Zone, victory Town, Mount Emei, Leshan, Sichuan Patentee before: Emeishan TLS Pharmaceutical Co., Ltd. |
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