CN104001041A - Traditional Chinese medicine for treating cerebral infarction - Google Patents
Traditional Chinese medicine for treating cerebral infarction Download PDFInfo
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- CN104001041A CN104001041A CN201410217127.9A CN201410217127A CN104001041A CN 104001041 A CN104001041 A CN 104001041A CN 201410217127 A CN201410217127 A CN 201410217127A CN 104001041 A CN104001041 A CN 104001041A
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Abstract
The invention belongs to the technical field of pharmacy and particularly relates to a traditional Chinese medicine for treating cerebral infarction. The traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 25-40 parts of astragalus membranaceus, 15-32 parts of salviae miltiorrhizae, 15-30 parts of prepared rehmannia roots, 10-17 parts of pinellia ternate, 10-17 parts of fructus lycii, 8-14 parts of rhizoma chuanxiong, 10-15 parts of radix ophiopogonis, 7-14 parts of hawthorn, 8-18 parts of spina date seeds, 6-12 parts of gastrodia elata, 5-10 parts of ginseng extract, 7-9 parts of rhizoma acori graminei, 3-7 parts of ginkgo biloba extract, 10-20 parts of schisandra chinensis, 3-8 parts of immature bitter oranges, 2-9 parts of poria cocos and 2-10 parts of liquorice. The traditional Chinese medicine provided by the invention has the beneficial effects that I, the traditional Chinese medicine can better achieve the effects of tonifying the liver and kidney and converging and inducing astringency while treats cerebral infarction; II, by adopting a method of traditional Chinese medicine matching, the immunity of the body is improved and the medicine is free from toxic and side effects while the medicine is used to treat symptoms.
Description
Technical field
The invention belongs to pharmaceutical technology field, in particular to a kind of Chinese medicine for the treatment of cerebral infarction.
Background technology
Along with improving constantly of living standard, the sickness rate of cardiovascular and cerebrovascular disease is obvious ascendant trend, has become the puzzlement mankind's second largest disease at present; The cause of disease more complicated of cardiovascular and cerebrovascular disease, form of expression variation, cerebral infarction is a kind of common cerebrovascular class disease, cerebral infarction is cerebrovascular Serious Stenosis or obturation, cause cerebral blood flow blocking-up and make cerebral tissue generation ischemic necrosis and softening, belong to common clinical, account for the 50%-60% of all acute cerebrovascular disease.Conventional medicine has gingko leaf preparation clinically, FUFANG DANSHEN DIWAN etc., these drug mains will bias toward the disease for the treatment of cardiovascular aspect, and it is actually rare to bias toward the Chinese medicine of disease for the treatment of cerebrovascular class, the medicine cost of cerebral infarction is higher at present, and curative effect is undesirable.Therefore the Chinese medicine of researching and developing a kind of safe and effective treatment cerebral infarction is very with practical value.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of cerebral infarction and preparation method thereof.
Treat a Chinese medicine for cerebral infarction, formed by the medical material of following weight portion: Radix Astragali 25-40 part, Radix Salviae Miltiorrhizae 15-32 part, Radix Rehmanniae Preparata 15-30 part, Rhizoma Pinelliae 10-17 part, Fructus Lycii 10-17 part, Rhizoma Chuanxiong 8-14 part, Radix Ophiopogonis 10-15 part, Fructus Crataegi 7-14 part, Semen Ziziphi Spinosae 8-18 part, Rhizoma Gastrodiae 6-12 part, Radix Ginseng extract 5-10 part, Rhizoma Acori Graminei 7-9 part, Folium Ginkgo extract 3-7 part, Fructus Schisandrae Chinensis 10-20 part, Fructus Aurantii Immaturus 3-8 part, Poria 2-9 part, Radix Glycyrrhizae 2-10 part.
Wherein, formed by the medical material of following weight portion: 36 parts of the Radixs Astragali, 17 parts of Radix Salviae Miltiorrhizaes, 18 parts of Radix Rehmanniae Preparata, 15 parts of the Rhizoma Pinelliaes, 15 parts of Fructus Lycii, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Ophiopogonis, 10 parts of Fructus Crataegis, 10 parts of Semen Ziziphi Spinosaes, 10 parts, Rhizoma Gastrodiae, 8 parts of Radix Ginseng extracts, 8 parts of Rhizoma Acori Graminei, 5 parts of Folium Ginkgo extract, 14 parts of Fructus Schisandrae Chinensis, 5 parts of Fructus Aurantii Immaturuss, 5 parts, Poria, 5 parts, Radix Glycyrrhizae.
Wherein, described Radix Ginseng extract is made by following method: extraction: get ginseng crude drug, pulverized 20-40 mesh sieve, the deionized water that the 5-10 of interpolation raw materials quality doubly measures, extracts 2-5 time, and extracting temperature is 50-80 DEG C, and extraction time is 3-5 hour, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant; Refining: supernatant is through resin absorption, and washing, after remove impurity, with the ethanol elution of 50-70%, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Radix Ginseng extract.
Wherein, described Folium Ginkgo extract is made by following method: extraction: get Folium Ginkgo raw material, the deionized water that the 5-10 of interpolation raw materials quality doubly measures, application citric acid regulates the pH value 2-5 of deionized water, extract 2-5 time, extract temperature be, 65-85 DEG C, extraction time is 1-3 hour, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant;
Refining: supernatant is through resin absorption, and washing, after remove impurity, with the ethanol elution of 50-70%, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Folium Ginkgo extract.
Wherein, the preferred AB-8 of described resin, the macroporous adsorbent resin of DM-130 model.
Wherein, described Chinese medicine can be made as decoction, oral liquid or granule.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:
1, background information
Select 80 routine cerebral infarction patients, wherein male 40 examples, female's 40 examples, age 35-65 year, the course of disease 2 days-3 years.
2 Therapeutic Method
The capsule that the preferred specific embodiment 1 of the oral the present invention for the treatment of group makes, every day 2 times, 15 days courses for the treatment of.
Observation item: to headache, dizziness, facial hemiparalysis, the symptoms such as hemianesthesia are observed.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.
Take a turn for the better: clinical symptom relief, test chamber inspection improves or be normal.
Invalid: clinical symptoms is without being clearly better or increasing the weight of.
3.2 treatment statistical results.
62 examples of fully recovering, 14 examples that take a turn for the better, invalid 4 examples, total effective rate is 95%.
Visible, the medicine that the preferred embodiment for the present invention makes can safe and effective treatment cerebral infarction.
Beneficial effect of the present invention is: 1,, in to cerebral infarction treatment, can well play liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating effect; 2, the method that adopts drug matching, made in the sanatory while, improved the immunity of body, had no side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, the embodiment providing is only in order to illustrate the present invention, instead of in order to limit the scope of the invention.
Experimental technique in following embodiment, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is and purchases available from routine biochemistry reagent shop.
embodiment 1:
Take 25 grams of the Radixs Astragali, 15 grams of Radix Salviae Miltiorrhizaes, 15 grams of Radix Rehmanniae Preparata, 17 grams of the Rhizoma Pinelliaes, 17 grams of Fructus Lycii, 8 grams of Rhizoma Chuanxiongs, 10 grams of Radix Ophiopogonis, 7 grams of Fructus Crataegis, 8 grams of Semen Ziziphi Spinosaes, 6 grams, Rhizoma Gastrodiae, 7 grams of Rhizoma Acori Graminei, 10 grams of Fructus Schisandrae Chinensis, 3 grams of Fructus Aurantii Immaturuss, 2 grams, Poria, 2 grams, Radix Glycyrrhizae, adds 9 times of water gagings, decocts 3 hours, filters; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, add 10 grams of Radix Ginseng extracts, 3 grams of Folium Ginkgo extract, then add appropriate dextrin and correctives, and to granulate according to this area common process, packaging, obtains granule.
Radix Ginseng extract is made by following method: extraction: get ginseng crude drug, pulverized 20 mesh sieves, add the deionized water of 5 times of amounts of raw materials quality, extract 5 times, extracting temperature is 60 DEG C, and extraction time is 3 hours, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant; Refining: supernatant is through AB-8 resin absorption, and washing, after remove impurity, with 50% ethanol elution, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Folium Ginkgo extract.
Folium Ginkgo extract is made by following method: extraction: get Folium Ginkgo raw material, add the deionized water of 5 times of amounts of raw materials quality, application citric acid regulates the pH value 2 of deionized water, extracts 2 times, and extracting temperature is 85 DEG C, and extraction time is 3 hours, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant; Refining: supernatant is through resin absorption, and washing, after remove impurity, with 50% ethanol elution, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Folium Ginkgo extract.
embodiment 2:
Take 10 grams of the Rhizoma Pinelliaes, 4 grams of Arisaema Cum Bile, 4 grams of Exocarpium Citri Rubrums, 4 grams of Fructus Aurantii Immaturuss, 4 grams, Poria, 4 grams, Radix Glycyrrhizae, 10 grams, Rhizoma Zingiberis Recens; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, add 10 grams of natto powders, pack, must meet the powder of one day consumption of normal adult.
Take 40 grams of the Radixs Astragali, 32 grams of Radix Salviae Miltiorrhizaes, 30 grams of Radix Rehmanniae Preparata, 10 grams of the Rhizoma Pinelliaes, 17 grams of Fructus Lycii, 14 grams of Rhizoma Chuanxiongs, 15 grams of Radix Ophiopogonis, 14 grams of Fructus Crataegis, 18 grams of Semen Ziziphi Spinosaes, 12 grams, Rhizoma Gastrodiae, 9 grams of Rhizoma Acori Graminei, 20 grams of Fructus Schisandrae Chinensis, 3 grams of Fructus Aurantii Immaturuss, 2 grams, Poria, 10 grams, Radix Glycyrrhizae, adds 8 times of water gagings, decocts 2 hours, filters; Filtering residue adds 7 times of water gagings, decocts 2 hours, filters; Merging filtrate, concentrated, 5 grams of Radix Ginseng extracts, 7 grams of Folium Ginkgo extract, stir evenly, and obtain decoction.
Radix Ginseng extract is made by following method: extraction: get ginseng crude drug, pulverized 40 mesh sieves, add the deionized water of 10 times of amounts of raw materials quality, extract 2 times, extracting temperature is 80 DEG C, and extraction time is 5 hours, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant; Refining: supernatant is through AB-8 resin absorption, and washing, after remove impurity, with 70% ethanol elution, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Radix Ginseng extract.
Folium Ginkgo extract is made by following method: extraction: get Folium Ginkgo raw material, add the deionized water of 10 times of amounts of raw materials quality, application citric acid regulates the pH value 5 of deionized water, extracts 5 times, and extracting temperature is 65 DEG C, and extraction time is 1 hour, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant; Refining: supernatant is through resin absorption, and washing, after remove impurity, with 70% ethanol elution, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Folium Ginkgo extract.
Said medicine is used for the treatment of cerebral infarction, early ante cibum, (medicine) being taken before meal use after supper, 2 times on the one.
embodiment 3:
Take 20 grams of the Rhizoma Pinelliaes, 6 grams of Arisaema Cum Bile, 6 grams of Exocarpium Citri Rubrums, 6 grams of Fructus Aurantii Immaturuss, 6 grams, Poria, 6 grams, Radix Glycyrrhizae, 20 grams, Rhizoma Zingiberis Recens; Add 6 times of water gagings, decoct 3 times, decoct 1 hour at every turn, merge decoction liquor, concentrated, add 20 grams of natto powders, then add appropriate dextrin and correctives,
Take 36 grams of the Radixs Astragali, 17 grams of Radix Salviae Miltiorrhizaes, 18 grams of Radix Rehmanniae Preparata, 15 grams of the Rhizoma Pinelliaes, 15 grams of Fructus Lycii, 12 grams of Rhizoma Chuanxiongs, 12 grams of Radix Ophiopogonis, 10 grams of Fructus Crataegis, 10 grams of Semen Ziziphi Spinosaes, 10 grams, Rhizoma Gastrodiae, 8 grams of Rhizoma Acori Graminei, 14 grams of Fructus Schisandrae Chinensis, 5 grams of Fructus Aurantii Immaturuss, 5 grams, Poria, 5 grams, Radix Glycyrrhizae, adds 8 times of water gagings, decocts 2 hours, filters; Filtering residue adds 7 times of water gagings, decocts 2 hours, filters; Merging filtrate, concentrated, 8 grams of Radix Ginseng extracts, 5 grams of Folium Ginkgo extract, make oral liquid according to this area common process, packaging.
Radix Ginseng extract is made by following method: extraction: get ginseng crude drug, pulverized 30 mesh sieves, add the deionized water of 8 times of amounts of raw materials quality, extract 3 times, extracting temperature is 50 DEG C, and extraction time is 4 hours, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant; Refining: supernatant is through resin absorption, and washing, after remove impurity, with 60% ethanol elution, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Radix Ginseng extract.
Folium Ginkgo extract is made by following method: extraction: get Folium Ginkgo raw material, add the deionized water of 8 times of amounts of raw materials quality, application citric acid regulates the pH value 3 of deionized water, extracts 3 times, and extracting temperature is 76 DEG C, and extraction time is 2 hours, merge extractive liquid; Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant; Refining: supernatant is through resin absorption, and washing, after remove impurity, with 60% ethanol elution, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Folium Ginkgo extract.
Above one embodiment of the present of invention are had been described in detail, but described content is only preferred embodiment of the present invention, can not be considered to for limiting practical range of the present invention.All equalization variation and improvement etc. of doing according to the present patent application scope, within all should belonging to patent covering scope of the present invention.
Claims (6)
1. a Chinese medicine for the treatment of cerebral infarction, is characterized in that: the medical material by following weight portion forms: Radix Astragali 25-40 part, Radix Salviae Miltiorrhizae 15-32 part, Radix Rehmanniae Preparata 15-30 part, Rhizoma Pinelliae 10-17 part, Fructus Lycii 10-17 part, Rhizoma Chuanxiong 8-14 part, Radix Ophiopogonis 10-15 part, Fructus Crataegi 7-14 part, Semen Ziziphi Spinosae 8-18 part, Rhizoma Gastrodiae 6-12 part, Radix Ginseng extract 5-10 part, Rhizoma Acori Graminei 7-9 part, Folium Ginkgo extract 3-7 part, Fructus Schisandrae Chinensis 10-20 part, Fructus Aurantii Immaturus 3-8 part, Poria 2-9 part, Radix Glycyrrhizae 2-10 part.
2. a kind of Chinese medicine for the treatment of cerebral infarction according to claim 1, is characterized in that: the medical material by following weight portion forms: 36 parts of the Radixs Astragali, 17 parts of Radix Salviae Miltiorrhizaes, 18 parts of Radix Rehmanniae Preparata, 15 parts of the Rhizoma Pinelliaes, 15 parts of Fructus Lycii, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Ophiopogonis, 10 parts of Fructus Crataegis, 10 parts of Semen Ziziphi Spinosaes, 10 parts, Rhizoma Gastrodiae, 8 parts of Radix Ginseng extracts, 8 parts of Rhizoma Acori Graminei, 5 parts of Folium Ginkgo extract, 14 parts of Fructus Schisandrae Chinensis, 5 parts of Fructus Aurantii Immaturuss, 5 parts, Poria, 5 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine for the treatment of cerebral infarction according to claim 1, is characterized in that: described Radix Ginseng extract is made by following method:
Extraction: get ginseng crude drug, pulverized 20-40 mesh sieve, the deionized water that the 5-10 of interpolation raw materials quality doubly measures, extracts 2-5 time, and extracting temperature is 50-80 DEG C, and extraction time is 3-5 hour, merge extractive liquid;
Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant;
Refining: supernatant is through resin absorption, and washing, after remove impurity, with the ethanol elution of 50-70%, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Radix Ginseng extract.
4. a kind of Chinese medicine for the treatment of cerebral infarction according to claim 1, is characterized in that: described Folium Ginkgo extract is made by following method:
Extraction: get Folium Ginkgo raw material, the deionized water that the 5-10 of interpolation raw materials quality doubly measures, application citric acid regulates the pH value 2-5 of deionized water, extracts 2-5 time, extract temperature to be, 65-85 DEG C, extraction time is 1-3 hour, merge extractive liquid;
Centrifugal: extracting solution is cooled to after room temperature, centrifugal removal impurity, obtains supernatant;
Refining: supernatant is through resin absorption, and washing, after remove impurity, with the ethanol elution of 50-70%, collects eluent, is evaporated to 1/5 of raw materials quality, obtains Radix Ginseng extract.
5. according to a kind of Chinese medicine for the treatment of cerebral infarction described in claim 3 or 4, it is characterized in that: the preferred AB-8 of described resin, the macroporous adsorbent resin of DM-130 model.
6. a kind of Chinese medicine for the treatment of cerebral infarction according to claim 1, is characterized in that: described Chinese medicine can be made as decoction oral liquid or granule.
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| CN201410217127.9A CN104001041A (en) | 2014-05-22 | 2014-05-22 | Traditional Chinese medicine for treating cerebral infarction |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225475A (en) * | 2014-09-18 | 2014-12-24 | 鲁娜 | Traditional Chinese medicine composition for treating cerebral apoplexy |
| CN104258284A (en) * | 2014-09-22 | 2015-01-07 | 苏雨行 | Oral preparation for cerebral apoplexy and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101837101A (en) * | 2009-03-20 | 2010-09-22 | 陕西步长制药有限公司 | Traditional Chinese medicine anther cap for controlling cardiovascular and cerebrovascular diseases, preparing method and quality control method thereof |
| CN102626428A (en) * | 2012-04-15 | 2012-08-08 | 徐州医学院 | Ginkgo leaf extract osmotic pump controlled-release preparation and preparation method thereof |
-
2014
- 2014-05-22 CN CN201410217127.9A patent/CN104001041A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101837101A (en) * | 2009-03-20 | 2010-09-22 | 陕西步长制药有限公司 | Traditional Chinese medicine anther cap for controlling cardiovascular and cerebrovascular diseases, preparing method and quality control method thereof |
| CN102626428A (en) * | 2012-04-15 | 2012-08-08 | 徐州医学院 | Ginkgo leaf extract osmotic pump controlled-release preparation and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225475A (en) * | 2014-09-18 | 2014-12-24 | 鲁娜 | Traditional Chinese medicine composition for treating cerebral apoplexy |
| CN104258284A (en) * | 2014-09-22 | 2015-01-07 | 苏雨行 | Oral preparation for cerebral apoplexy and preparation method thereof |
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