CN103070909B - Three stilbene soft capsules and preparation method thereof - Google Patents
Three stilbene soft capsules and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Radix Astragali soft capsule of Cardiovarscular, its composition is simple, and be characterised in that raw material weight proportioning is: Radix Notoginseng extract 60-80, Radix Astragali extract 40-60, soybean oil 220-280, makes soft capsule.The invention still further relates to the preparation method of this capsule simultaneously, especially have employed point temperature stage by stage and extract and be equipped with the technology of ultrasonic extraction, very big simple type and the safety that improve production, optimizes production technology.
Description
Technical field
The present invention relates to the preparation field of cardiovascular disease medicine, especially, relate to a kind of three stilbene soft capsules and preparation method thereof.
Background technology
Cardiovascular disease, be also called blood circulation diseases, a series of diseases relating to blood circulation, blood circulation refers to hemophoric Organ and tissue in human body, mainly comprise heart, blood vessel (tremulous pulse, vein, blood capillary), can be subdivided into acute and chronic, be all generally relevant with arteriosclerosis.These diseases have the similar cause of disease, sick process and Therapeutic Method.
Radix Notoginseng has another name called Radix Notoginseng, and the famous pharmacy man Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is called " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ".Radix Notoginseng is a jewel in Chinese crude drug, records in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica: " ginseng qi-tonifying the first, Radix Notoginseng enriches blood the first, taste with and merit also etc., therefore claiming Panax pseudoginseng, is the most precious person in Chinese medicine." become famous Chinese patent medicine " YUNNAN BAIYAO " at home and abroad and " sheet is young yellow ", be namely that primary raw material is made with Radix Notoginseng.Radix Notoginseng belongs to Araliaceae herbaceos perennial, adopts and long three petioles of every strain, raw seven blades of each petiole, therefore named Radix Notoginseng because it digs for after planting 3 to seven years.Its stem, leaf, Hua Junke are used as medicine.
The Radix Astragali, has another name called Radix Astragali, is the general designation of plant and Chinese crude drug.The plant Radix Astragali originates in the ground such as the Inner Mongol, Shanxi, Gansu, Heilungkiang, is state three level protecting plant.The Chinese crude drug Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Radix Notoginseng total arasaponins is the main component of Radix Notoginseng, it is a kind of important Radix Notoginseng extract, protective effect is had to cardiac muscle, there is resisting coronary heart disease effect, coronary flow can be increased, improve Myocardial Microcirculation, the state of adjustment myocardial ischemia-anoxemia, protective effect is had to cerebral tissue, after making full brain or focal cerebral ischemia, Reperfu-sion edema obviously alleviates, brain blood barrier permeability improves, bleeding in local significantly increases, have and expand blood vessel and hypotensive effect, flow of calcium ions effect caused by norepinephrine capable of blocking, also has analgesia in addition, antiinflammatory, blood fat reducing, the multiple pharmacological effect such as immunomodulating.The Radix Astragali all has good action to cardiovascular system, blood system, renal function, substance metabolism and tumor etc., the blood cell count of minimizing can be made to recover normal, coronary artery dilator, improve cardiac function, strengthen antioxidant capacity, prevent lipid peroxidation, improve renal function, prevent hepatic glycogen from reducing, defying age, strengthen collective's nonspecific immunity and enhancing body resistance.
Also there is a lot of record about the medicine that cardiovascular disease is used in prior art, and have the agents in combination such as Radix Notoginseng extract and the Radix Astragali to use the medicine of preparation to record equally.Such as:
1, patent " a kind of pharmaceutical composition containing Radix Notoginseng total arasaponins and Radix Astragali extract ".Application number: 200510044416.4
2, patent " a kind of Chinese medicine compound notoginseng soft capsule and preparation method thereof ".Application Number (patent): CN02121219.8
Such as, but these pharmaceutical compositions are all conventional methods for the extraction of material effective component, and alcohols extracts, or the hot water extraction of uniform temperature, and water extraction and alcohol extraction are the conventional method of this area Chinese medicine extracts active ingredients equally.Although the optimum process condition of the method that some prior art is extracted for hot water etc. had research, such as:
" new method passes judgment on the factory formula of Radix Notoginseng composite health care beverage ", Xiao Mei etc., " Food Science "
" development of panax notoginseng healthcare beverage ", Cai Jun etc., " beverage industry "
" development of panax notoginseng healthcare beverage ", Xie Chengjun etc., " Agriculture of Anhui science " etc.
But these methods just on the basis of routine techniques by optimum process condition that the contrast test of some draws.
Following deficiency is there is and defect comprises in prior art:
1, the extraction process redundant and complicated of raw material, extremely low in raw-material utilization rate, waste is comparatively large, and the cost performance of whole technique is very low.
Even 2 with in the prior art of hot water extraction, all have employed the method for the permanent water addition of constant temperature, whole process is comparatively tediously long, and energy consumption is higher.
3, product composition is complicated.Etc..
Summary of the invention
One object of the present invention there are provided a kind of three stilbene soft capsules, and its composition is simple, and be characterised in that raw material weight proportioning is: Radix Notoginseng extract 60-80, Radix Astragali extract 40-60, soybean oil 220-280, makes soft capsule.
Preferably, Radix Notoginseng extract 70, Radix Astragali extract 50, soybean oil 250
Another object of the present invention is the preparation method providing described three stilbene soft capsules, it is characterized in that:
(1) preparation of Radix Notoginseng extract:
Get Radix Notoginseng raw material 8-10 times of pure water, ultrasonic extraction 8-10 minute at 65-70 DEG C, add ultrasonic extraction 10-12 minute at water 70-75 DEG C of raw material 10-12 times amount afterwards again, add ultrasonic extraction 12-15 minute at water 75-80 DEG C of raw material 12-15 times amount afterwards again, filter, filtrate is concentrated into extractum, dry, pulverize;
(2) preparation of Radix Astragali extract:
Get Astragalus membranaceus raw material 10-12 times pure water, ultrasonic extraction 10-12 minute at 60-68 DEG C, add ultrasonic extraction 12-15 minute at water 65-70 DEG C of raw material 12-16 times amount afterwards again, add ultrasonic extraction 12-15 minute at water 70-75 DEG C of raw material 15-18 times amount afterwards again, filter, filtrate is concentrated into extractum, dry, pulverize;
(3) by Radix Notoginseng extract, Radix Astragali extract, makes soft capsule after soybean oil is mixed in proportion.
Especially, in Radix Notoginseng extract preparation process, hyperacoustic frequency is 35-40Hz, and in Radix Astragali extract preparation process, hyperacoustic frequency is 28-33Hz.
Especially, raw material passed through and pulverizes before extraction.
The invention has the advantages that different heating temperature, is equipped with the method for microwave extraction simultaneously, higher to the extraction efficiency of material effective component, and waste is less, and does not need very high temperature, therefore controls the energy consumption of whole process by three stages different water consumption.Invention also improves the safety of technique simultaneously.
Finally determine a kind of three stilbene soft capsules more outstanding than row, this capsule has good therapeutical effect to cardiovascular disease etc. simultaneously.
Detailed description of the invention
Embodiment 1
(1) preparation of Radix Notoginseng extract:
Get Radix Notoginseng raw material 8 times of pure water, ultrasonic extraction 10 minutes at 65 DEG C, to add at 70 DEG C, the water of raw material 10 times amount ultrasonic extraction afterwards again 12 minutes, to add at 75 DEG C, the water of raw material 12 times amount ultrasonic extraction afterwards again 15 minutes, filter, filtrate is concentrated into extractum, dry, pulverize; Wherein hyperacoustic frequency is 35Hz;
(2) preparation of Radix Astragali extract:
Get Astragalus membranaceus raw material 10 times of pure water, ultrasonic extraction 12 minutes at 60 DEG C, to add at 65 DEG C, the water of raw material 12 times amount ultrasonic extraction afterwards again 15 minutes, to add at 70 DEG C, the water of raw material 15 times amount ultrasonic extraction afterwards again 15 minutes, filter, filtrate is concentrated into extractum, dry, pulverize; Wherein hyperacoustic frequency is 28Hz;
(3) by Radix Notoginseng extract, Radix Astragali extract, soybean oil makes soft capsule by the weight ratio of 60: 40: 220.
Raw material is broken to 60 orders before extracting.
Embodiment 2
(1) preparation of Radix Notoginseng extract:
Get Radix Notoginseng raw material 10 times of pure water, ultrasonic extraction 8 minutes at 70 DEG C, to add at 75 DEG C, the water of raw material 12 times amount ultrasonic extraction afterwards again 10 minutes, to add at 80 DEG C, the water of raw material 15 times amount ultrasonic extraction afterwards again 12 minutes, filter, filtrate is concentrated into extractum, dry, pulverize; Wherein hyperacoustic frequency is 38Hz
(2) preparation of Radix Astragali extract:
Get Astragalus membranaceus raw material 12 times of pure water, ultrasonic extraction 10 minutes at 68 DEG C, to add at 70 DEG C, the water of raw material 16 times amount ultrasonic extraction afterwards again 12 minutes, to add at 75 DEG C, the water of raw material 18 times amount ultrasonic extraction afterwards again 12 minutes, filter, filtrate is concentrated into extractum, dry, pulverize; Wherein hyperacoustic frequency is 30Hz
(3) by Radix Notoginseng extract, Radix Astragali extract, soybean oil makes soft capsule by after the part by weight mixing of 70: 50: 250.
Raw material is broken to 50 orders before extracting.
Embodiment 3
(1) preparation of Radix Notoginseng extract:
Get Radix Notoginseng raw material 9 times of pure water, ultrasonic extraction 9 minutes at 68 DEG C, to add at 72 DEG C, the water of raw material 11 times amount ultrasonic extraction afterwards again 11 minutes, to add at 78 DEG C, the water of raw material 13 times amount ultrasonic extraction afterwards again 13 minutes, filter, filtrate is concentrated into extractum, dry, pulverize; Wherein hyperacoustic frequency is 40Hz
(2) preparation of Radix Astragali extract:
Get Astragalus membranaceus raw material 11 times of pure water, ultrasonic extraction 11 minutes at 65 DEG C, to add at 68 DEG C, the water of raw material 14 times amount ultrasonic extraction afterwards again 13 minutes, to add at 72 DEG C, the water of raw material 16 times amount ultrasonic extraction afterwards again 14 minutes, filter, filtrate is concentrated into extractum, dry, pulverize; Wherein hyperacoustic frequency is 33Hz
(3) by Radix Notoginseng extract, Radix Astragali extract, soybean oil makes soft capsule by after 80: 60: 280 part by weight mixing.
Raw material is broken to 50 orders before extracting.
Claims (3)
1. a preparation method for three stilbene soft capsules, is characterized in that comprising following steps:
(1) preparation of Radix Notoginseng extract:
Get Radix Notoginseng raw material 8-10 times of pure water, ultrasonic extraction 8-10 minute at 65-70 DEG C, add ultrasonic extraction 10-12 minute at water 70-75 DEG C of raw material 10-12 times amount afterwards again, add ultrasonic extraction 12-15 minute at water 75-80 DEG C of raw material 12-15 times amount afterwards again, filter, filtrate is concentrated into extractum, dry, pulverize, hyperacoustic frequency is 35-40Hz;
(2) preparation of Radix Astragali extract:
Get Astragalus membranaceus raw material 10-12 times pure water, ultrasonic extraction 10-12 minute at 60-68 DEG C, add ultrasonic extraction 12-15 minute at water 65-70 DEG C of raw material 12-16 times amount afterwards again, add ultrasonic extraction 12-15 minute at water 70-75 DEG C of raw material 15-18 times amount afterwards again, filter, filtrate is concentrated into extractum, dry, pulverize, hyperacoustic frequency is 28-33Hz;
(3) by Radix Notoginseng extract, Radix Astragali extract, soybean oil makes soft capsule by after the weight ratio mixing of 60-80: 40-60: 220-280.
2. method according to claim 1, wherein Radix Notoginseng raw material and Astragalus membranaceus raw material are before extraction through pulverizing.
3. method according to claim 1 and 2, wherein the weight proportion of Radix Notoginseng extract, Radix Astragali extract and soybean oil is: Radix Notoginseng extract 70, Radix Astragali extract 50, soybean oil 250.
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| CN105124365A (en) * | 2015-07-20 | 2015-12-09 | 龚启萍 | Fruit and vegetable rice flour having intestine-moistening and bowel-relaxing effects |
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| LT5433B (en) * | 2003-09-23 | 2007-07-25 | Tianjin Tasly Pharmaceuticals Co., Ltd. | Pharmaceutical composition for the treatment of cardiovascular and cerebrovascular diseases |
| CA2538478C (en) * | 2003-09-23 | 2013-02-19 | Tianjin Tasly Pharmaceutical Co., Ltd. | A pharmaceutical composition for the treatment of cardiovascular and cerebrovascular diseases |
| CN1559427A (en) * | 2004-02-24 | 2005-01-05 | 成都和康药业有限责任公司 | Medicine compound for treating cardiovascular and cerebrovascular diseases |
| CN1762401A (en) * | 2004-09-24 | 2006-04-26 | 贵阳云岩西创药物科技开发有限公司 | Compound formulation of notoginseng for treating cardiovascular and cerebrovascular diseases, preparation method and application thereof |
| CN1634254A (en) * | 2004-10-15 | 2005-07-06 | 贵阳云岩西创药物科技开发有限公司 | Compound formulation of astragalus root for treating cardiovascular and cerebrovascular diseases and its preparing process |
| CN1634970A (en) * | 2004-11-18 | 2005-07-06 | 张平 | Process for preparing notoginsen triterpenes |
| CN1981801A (en) * | 2005-12-12 | 2007-06-20 | 北京奇源益德药物研究所 | Chinese-medicinal preparation for treating cardiovascular diseases, its production and use |
| CN1981800A (en) * | 2005-12-12 | 2007-06-20 | 北京奇源益德药物研究所 | Chinese-medicinal preparation for treating cardiovascular diseases, its production and use |
| CN101810337A (en) * | 2010-05-11 | 2010-08-25 | 苏豹 | Health food containing pseudo-ginseng and ganoderma lucidum and radix astragali |
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Correction item: Patentee|Address|Patentee Correct: Wenshan gold seven Pharmaceutical Co., Ltd.|Seven Township seven township Garden Road 663100 Yunnan Province Yanshan County River town (the collection near the supermarket) False: Wenshan gold seven Pharmaceutical Co., Ltd.|Seven Township seven township Garden Road 663100 Yunnan Province Yanshan County River town (the collection near the supermarket)|Yunnan Jinqi Pharmaceutical Co., Ltd. Number: 49-02 Volume: 33 |
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Address after: 663100 Yunnan Prefecture of Wenshan Province, the Yanxin Yanshan County highway that Jiang Town Ma Village concave Patentee after: JINQI PHARMACEUTICALS CO.,LTD. Address before: Seven Township seven township Garden Road 663100 Yunnan Province Yanshan County River town (the collection near the supermarket) Patentee before: WENSHAN JINQI PHARMACEUTICAL CO.,LTD. |
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