CN104940597A - Chinese herbal composition used for treating myocardial infarction, and preparation method of Chinese herbal composition - Google Patents
Chinese herbal composition used for treating myocardial infarction, and preparation method of Chinese herbal composition Download PDFInfo
- Publication number
- CN104940597A CN104940597A CN201510442919.0A CN201510442919A CN104940597A CN 104940597 A CN104940597 A CN 104940597A CN 201510442919 A CN201510442919 A CN 201510442919A CN 104940597 A CN104940597 A CN 104940597A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- fructus
- moringa
- leaf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to a Chinese herbal composition used for treating myocardial infarction and a preparation method of the Chinese herbal composition. The Chinese herbal composition is prepared from the following raw materials: moringa leaves, burdock, panax notoginseng, dandelion, fennel, gingko leaves, carthamus tinctorius, hawthorn, dogwood, cistanche deserticola, monkshood, ginseng, dwarf lilyturf turber, rhodobryum roseum Limp., and liquorice. The Chinese herbal composition has the efficacies of nourishing yin, tonifying the kidney, replenishing essence, nourishing blood, activating blood circulation to dissipate, invigorating spleen and tonifying qi, and has the advantages that the preparation process is simple; the curative effect is high; the side effect is low; the taking is convenient; the popularization and the application are easy.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof.
Background technology
Myocardial infarction is the disease of the part myocardial necrosis caused due to the lasting severe ischemic of cardiac muscle, and most heart infarction is on the basis of coronary atherosclerosis, and the spasm merging thrombosis or persistence makes tube chamber generation acute occlusion be formed.Multiple be born in the middle age after, have the symptom such as the similar anginal front chest pain of violent and lasting character, cardiopalmus, asthma, weak and faint pulse, blood pressure reduction during morbidity.Myocardial ischemia also can damage diastolic function.Shrink bad and diastole is bad combines, easily cause ventricular filling pressure to raise, cause pulmonary congestion, also can cause complicated substance metabolism disorder and myocardial electrical activity not normal.Primary disease incidence rate has and increases trend year by year, and arteriosclerosis accounts for 98% of Pathogenesis of Acute Myocardial Infarction rate.Male is more than women, but with age, M-F difference reduces gradually.This patient more than 40 years old is in the majority, and many with hypertension.Nearly half is angor medical history intentionally.
In treatment, "Nei Jing" establishes some rule for the treatment of, is broadly divided into two classes: one is take stopgap measures and effect a permanent cure, i.e. " symptomatic treatment in acute condition, radical treatment in chronic case "; Two is routine treatment and contrary treatment, i.e. " treating with drugs opposite to the nature of disease is called routine treatment, contrary treatment means that the remedy coincides with the pseudo-symptom of disease ", and the one that routine treatment is its syndrome character inverse and controls commonly uses therapeutic rules, and contrary treatment is a kind of Therapeutic Method of being obedient to disease illusion and controlling, and this is that the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of later age is laid a good foundation.The present traditional Chinese medical science thinks that the main pathogenesis of coronary heart disease myocardial infarction is deficiency in origin and excess in superficiality, and deficiency in origin is based on the deficiency of vital energy, the deficiency of YIN, and mark is real turbid common with the stagnation of QI, blood stasis, expectorant.The ancient prescription traditional Chinese medical science then thinks that the stagnation of QI, blood stasis, expectorant are turbid, makes blood vessels obstructed and the thoracic obstruction occurs.The ancient prescription traditional Chinese medical science proposes phlegm and blood stasis theory, thinks body fluid transporting mistake department, stops poly-ly forming expectorant; Escape of blood from meridians, stays in arteries and veins outer or stagnant in arteries and veins, causes blood stasis expectorant to stop or expectorant is poly-hinders blood; Or the expectorant stasis of blood is changed mutually, stagnant in passages through which vital energy circulates to expectorant stasis blocking eventually, phlegm and blood stasis and causing a disease.And myocardial infarction be divided into type of deficiency of both QI and YIN, deficiency of YANG QI weak type, the expectorant stasis of blood to hand over three types such as resistance qi stagnation and blood stasis type, control respectively with supplementing QI and nourishing YIN, QI invigorating warming YANG, dissipating phlegm and removing blood stasis.The thoracic obstruction is divided into heart deficiency of spleen-QI by the ancient prescription traditional Chinese medical science, sluggishness of qi and phlegm, control nourish heart with QI invigorating, the chest stuffiness relieving reason expectorant; Yang-energy is weak, cold coagulation phlegm stagnation syndrome type, controls with QI invigorating warming YANG, dispelling cold and eliminating phlegm; The hepatic and renal YIN deficiency, blood stasis yang-excess type, control with nourishing the liver and kidney, YANG hyperactivity suppressing blood stasis dispelling; Deficiency of both YIN and YANG, qi stagnation and blood stasis type, control with tonifying both YIN and YANG, blood-activating analgetic; The de-inverse type of fainting of cardiorenal failure, sun, controls with the kidney warming heart tonifying, recuperating depleted YANG and rescuing the patient from collapse.
China applies for a patent 201410113088.8 and discloses a kind of Chinese medicine composition for the treatment of myocardial infarction, it comprises the raw material of following parts by weight: Galla Chinensis 15 parts, Flos Lonicerae 6 parts, the Cortex Eucommiae 10 parts, Radix Cirsii Japonici 10 parts, Rhizoma Chuanxiong 10 parts, Radix Rehmanniae 20 parts, Periostracum Cicadae 20 parts, 10 parts, Poria, the Radix Paeoniae Alba 5 parts, Radix Codonopsis 5 parts and 10 parts, Radix Glycyrrhizae, this Chinese medicine composition has good therapeutic effect in treatment myocardial infarction, there is significant clinical generalization value, but effect not very remarkable in supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of myocardial infarction, this Chinese medicine composition has effect of nourishing YIN and supplementing the kidney, replenishing essence benefit blood, blood circulation promoting and blood stasis dispelling and invigorating the spleen and replenishing QI, also have that preparation technology is simple, good effect, side effect be low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
A kind of Chinese medicine composition for the treatment of myocardial infarction of the present invention is prepared from by the raw material of following parts by weight:
Leaf of Moringa 3-15 part, Fructus Arctii 6-15 part, Radix Notoginseng 3-9 part, Herba Taraxaci 9-15 part, Fructus Foeniculi 6-15 part, Folium Ginkgo 3-10 part, Flos Carthami 3-9 part, Fructus Crataegi 9-12 part, Fructus Corni 6-12 part, Herba Cistanches 6-12 part, Radix Aconiti Lateralis Preparata 3-15 part, Radix Ginseng 3-9 part, Radix Ophiopogonis 3-15 part, Rhodobryum roseum Limpr. 6-9 part and Radix Glycyrrhizae 1-10 part.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 3 parts, Fructus Arctii 6 parts, Radix Notoginseng 3 parts, Herba Taraxaci 9 parts, 6 parts, Fructus Foeniculi, Folium Ginkgo 3 parts, 3 parts, Flos Carthami, Fructus Crataegi 9 parts, Fructus Corni 6 parts, Herba Cistanches 6 parts, Radix Aconiti Lateralis Preparata 3 parts, Radix Ginseng 3 parts, Radix Ophiopogonis 3 parts, Rhodobryum roseum Limpr. 6 parts and 1 part, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 15 parts, Fructus Arctii 15 parts, Radix Notoginseng 9 parts, Herba Taraxaci 15 parts, 15 parts, Fructus Foeniculi, Folium Ginkgo 10 parts, 9 parts, Flos Carthami, Fructus Crataegi 12 parts, Fructus Corni 12 parts, Herba Cistanches 12 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Ginseng 9 parts, Radix Ophiopogonis 15 parts, Rhodobryum roseum Limpr. 9 parts and 10 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 10 parts, Fructus Arctii 10 parts, Radix Notoginseng 6 parts, Herba Taraxaci 12 parts, 12 parts, Fructus Foeniculi, Folium Ginkgo 7 parts, 6 parts, Flos Carthami, Fructus Crataegi 10 parts, Fructus Corni 9 parts, Herba Cistanches 9 parts, Radix Aconiti Lateralis Preparata 9 parts, Radix Ginseng 6 parts, Radix Ophiopogonis 10 parts, Rhodobryum roseum Limpr. 7 parts and 9 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is oral formulations.
Again further, described oral formulations is tablet, capsule, drop pill, granule, powder or oral liquid.
Accordingly, the preparation method of described Chinese medicine composition comprises following step:
Step one: preparation moringa oleifera leaf extractive: take leaf of Moringa, leaf of Moringa is put into volume be leaf of Moringa volume 1-20 doubly and the water that temperature is 5-20 DEG C flood, flood after 30-60 minute, collect leaf of Moringa leachate, remove insoluble substance, filter, obtain moringa oleifera leaf extractive;
Step 2: take Fructus Arctii, Radix Notoginseng, Herba Taraxaci, Fructus Foeniculi, Folium Ginkgo, Flos Carthami, Fructus Crataegi, Fructus Corni, Herba Cistanches, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Rhodobryum roseum Limpr. and Radix Glycyrrhizae, add 3-8 times amount water soaking 1-3 hour, intense fire decocts boiling 30 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, 2-5 times of water gaging is added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.20-1.35, add the moringa oleifera leaf extractive that step one obtains, drying under reduced pressure, 100-120 mesh sieve is crossed after pulverizing, obtain Chinese medicine composition of the present invention.
Leaf of Moringa refers to the leaves of the perennial tropical deciduous tree Moringa tree (being also called drumstick tree) originating in India, leaf of Moringa has the effects such as blood sugar lowering, blood fat reducing, blood pressure lowering, antitumor, antioxidation, relieving constipation, diuresis, anthelmintic, improving water flood, and often edible leaf of Moringa can enhancing immunity, toxin expelling, body shaping, aging resistance, anticancer and have multiple chronic and major disease and improve effect greatly.Leaf of Moringa is natural green food, and the complete nutrients matter containing needed by human body, it can replace compound vitamin, calcium tablet, cod-liver oil etc.Good effect is had especially to hypertension, hyperlipidemia, diabetes, gout etc.In addition, leaf of Moringa can assist to improve, prevent disease, improving water flood, memory reinforcing, slow down aging, also can be used to the disease for the treatment of the privileged sites such as liver, spleen, meridians.It also has effect such as treatment halitosis and relieving alcoholic intoxication etc.
Fructus Arctii is Compositae draft taproot class plant, and be a kind of vegetable edible with loose fleshy tap root, petiole and tender leaf also edible, Fructus Arctii and Radix Arctii also can be used as medicine.The fiber of Fructus Arctii can promote intestinal peristalsis, helps defecation, reduces body inner cholesterol, and minimizing toxin, refuse accumulate in vivo, reaches prevention of stroke and the effect of preventing and treating gastric cancer, uterus carcinoma.Doctor trained in Western medicine thinks that it is except having diuresis, removing food stagnancy, eliminating the phlegm except the pharmacological actions such as stopping leak, also for the dietetic therapy of constipation, hypertension, high-cholesterol disease.The traditional Chinese medical science thinks effects such as having wind-dispelling heat-dissipating, lung qi dispersing rash, resolving toxin and disinhibiting the throat.
Radix Notoginseng is the dry root welding technology of panax araliaceae plant, has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.In addition, also have comprise hemostasis, antithrombotic, promotion hemopoietic, expand blood vessel, blood pressure lowering, resist myocardial ischemia, anti-cerebral ischemia, arrhythmia, atherosclerosis, antiinflammatory, protect the liver, antitumor, the effect such as analgesia, principle active component is PNS, PDS, PTS and Radix Notoginseng propylhomoserin.
Dandelion Compositae herbaceos perennial.Head inflorescence, the bobbles that on seed, adularescent pappus is formed, new life is bred in the new place that racks after the flowers are in blossom.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value simultaneously.In addition, also there is heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds.
The main component of Fructus Foeniculi is Oleum Anisi Stellati, energy stimulating gastrointestinal neural blood vessel, and facilitating digestion liquid is secreted, and increases gastrointestinal peristalsis, gets rid of the gas accumulated, so there is effect of stomach invigorating, circulation of qi promoting; Sometimes gastrointestinal peristalsis can reduce again after excitement, thus contributes to alleviating spasm, easing the pain.Chinese medicine is used as medicine, and warm in nature, acrid in the mouth, returns liver,kidney,spleen, stomach warp.Function warming the liver kidney, warming the stomach gas, loose plug knot, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.Fructus Foeniculi also has antiulcer, analgesia, gonadotropic Effect etc., and Oleum Anisi Stellati has antibacterial action in various degree.Energy stimulating gastrointestinal neural blood vessel, promotes saliva and gastric secretion, plays appetite stimulator, digestive effect.Be applicable to Deficiency and coldness of spleen and stomach.
Folium Ginkgo is the leaf of Ginkgoaceae plant Ginkgo biloba.Folium Ginkgo nature and flavor sweetness and bitterness is puckery flat, the effects such as the useful heart is astringed the lung, removing dampness antidiarrheal." Chinese medicinal herbal " records it can " gas of astringing the lung, relievings asthma and coughs, and leukorrhagia stopping is turbid ".According to modern pharmacological research, the effect of Folium Ginkgo to human body and animal body is comparatively extensive, as improved cardiovascular and peripheral vessels circulatory function, being improved effect to myocardial ischemia, having the effect promoting memory, improve brain function.In addition, blood viscosity, scavenging free radicals can also be reduced.
Flos Carthami belongs to feverfew, and shape is the corolla of tubular, and it has the effect of good promoting blood circulation to restore menstrual flow network, eliminating stasis to stop pain, the traditional Chinese medical science thinks that Flos Carthami nature and flavor are gentle, has a lot of benefits to the person.Prove by experiment, a small amount of Flos Carthami can make heart beating stronger, has a lot of benefit to myocardial ischemia, also has a function can expand expansion body hat tremulous pulse and femoral artery exactly.The spasm of vascular smooth muscle can also be removed and strengthen hypoxia-bearing capability, stoping further developing of thrombosis, reduce again the effect of cholesterol.The circulatory disturbance of heart and brain tissues can also be improved, coronary heart disease and cerebral thrombosis treatment are beneficial to.
Fructus Crataegi is containing multiple organic acid.Oral rear enhancing gastric acidity, improves pepsin activity, promotes the digestion of protein; Fructus Crataegi sour in the mouth, stimulates gastric mucosa to promote gastric secretion; Fatty enzyme in Fructus Crataegi, can promote the digestion of fat; Fructus Crataegi contains the compositions such as vitamin C, oral can appetite stimulator; Fructus Crataegi has regulating action to gastrointestinal motility function, there is inhibitory action to the gastrointestinal smooth muscle of spasticity, have excitation to the smooth muscle of relaxed state, in addition, Fructus Crataegi flavone, hydrolyzate increase ischemic myocardium nutrient flow amount, wherein the strongest with the effect of Fructus Crataegi hydrolyzate.Fructus Crataegi, while increase coronary artery blood flow, can also reduce myocardial oxygen consumption, improves coefficient of oxygen utilization.
Fructus Corni officinalis contains abundant nutrient substance and functional component, and the experience of the Compendium of Material Medica collection ancient Chinese medicine doctor application Fructus Corni of Ming Dynasty's Li Shizhen (1518-1593 A.D.), the medicine that Fructus Corni is classified as controlling nocturnal emission with astringent drugs of enriching blood, liver and kidney tonifying, regulating QI, tonify deficiency, improving eyesight and keeps fit.
Herba Cistanches contains the compositions such as abundant alkaloid, crystalline neutral substance, aminoacid, trace element, vitamin.Energy kidney-replenishing, benefiting essence-blood, can suppress the appearance of " yang deficiency " symptom, prevent from losing weight.Herba Cistanches is scalable blood circulation also, has following effect: protection ischemic myocardium; Blood fat reducing, atherosclerosis, antithrombus formation; Reduce peripheral vascular resistance, expansion peripheral blood vessel, reduces blood pressure; The liver protecting, anti-fatty liver.
Radix Aconiti Lateralis Preparata, has another name called Aconitum carmichjaelii Debx. or Radix Aconiti Lateralis Preparata, the processed goods of the daughter root of Ranunculaceae, aconitum plant.Function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain.
The superfine product that Radix Ginseng is described as from ancient times " king of BAICAO " " YIN nourishing is mended raw; strengthening the body resistance ", containing multiple Saponin and polysaccharide composition, leachate slowly can be absorbed by skin and without pessimal stimulation, energy skin expansion blood capillary, promotes cutaneous circulation, in addition, the fleshy tap root of Radix Ginseng is famous strong tonic, be applicable to adjustment blood pressure, recover the disease such as cardiac function, neurasthenia and physical weakness, also eliminate the phlegm, stomach invigorating, diuresis, the effect such as excitement.
Radix Ophiopogonis matter cold in nature profit, nourshing Yin and drynsessmoistening prescription effect is better, is applicable to the disease of elephant of yin asthenia generating intrinsic heat, dry cough body fluid deficiency, should not be used for that the water that insufficiency of the spleen transformation failure of spleen causes is wet, cold-damp, expectorant are turbid and the obvious disease of the deficiency of vital energy.
Rhodobryum roseum Limpr. is a kind of Chinese herbal medicine, and plant body is little, the micro-hardship of taste, can as the treatment of heart disease or other mental disorder.Specially control that heart disease is nervous, cardiopalmus, the symptoms such as neurasthenia.
Radix Glycyrrhizae is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., Radix Glycyrrhizae contains number of chemical composition, and main component has glycyrrhizic acid, liquiritin etc., in TCM academic, carry out coordinating the actions of various ingredients in a prescription through conventional Radix Glycyrrhizae, Radix Glycyrrhizae has the effects such as heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI, expelling phlegm for arresting cough.
Compared with prior art, the present invention has following technical advantage:
1, Chinese medicine composition of the present invention is compared with the medicine of other treatment myocardial infarction, in nourishing YIN and supplementing the kidney, replenishing essence benefit blood, blood circulation promoting and blood stasis dispelling and invigorating the spleen and replenishing QI etc., have more remarkable efficacy.
2, compared with the chemotherapeutic agent of Current therapeutic myocardial infarction, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, treats myocardial infarction disease from root.
3, Chinese medicine composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 3 parts, Fructus Arctii 6 parts, Radix Notoginseng 3 parts, Herba Taraxaci 9 parts, 6 parts, Fructus Foeniculi, Folium Ginkgo 3 parts, 3 parts, Flos Carthami, Fructus Crataegi 9 parts, Fructus Corni 6 parts, Herba Cistanches 6 parts, Radix Aconiti Lateralis Preparata 3 parts, Radix Ginseng 3 parts, Radix Ophiopogonis 3 parts, Rhodobryum roseum Limpr. 6 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: preparation moringa oleifera leaf extractive: take leaf of Moringa, puts into volume and is leaf of Moringa volume 10 times and the water that temperature is 10 DEG C floods, flood after 30 minutes by leaf of Moringa, collect leaf of Moringa leachate, remove insoluble substance, filter, obtain moringa oleifera leaf extractive;
Step 2: take Fructus Arctii, Radix Notoginseng, Herba Taraxaci, Fructus Foeniculi, Folium Ginkgo, Flos Carthami, Fructus Crataegi, Fructus Corni, Herba Cistanches, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Rhodobryum roseum Limpr. and Radix Glycyrrhizae, add 6 times amount water soaking 2 hours, intense fire decocts boiling 30 minutes, use slow fire boiling again 1 hour, filter, obtain filtrate, 3 times of water gagings are added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling again 1 hour, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.20, add the moringa oleifera leaf extractive that step one obtains, drying under reduced pressure, 100 mesh sieves are crossed after pulverizing, obtain Chinese medicine composition of the present invention.Add starch, water and rubber cement, mixing, stirs, is pressed into thin slice, be ground into granule, obtain the embodiment of the present invention 1 Chinese medicinal composition granules.
embodiment 2:
The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 15 parts, Fructus Arctii 15 parts, Radix Notoginseng 9 parts, Herba Taraxaci 15 parts, 15 parts, Fructus Foeniculi, Folium Ginkgo 10 parts, 9 parts, Flos Carthami, Fructus Crataegi 12 parts, Fructus Corni 12 parts, Herba Cistanches 12 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Ginseng 9 parts, Radix Ophiopogonis 15 parts, Rhodobryum roseum Limpr. 9 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: preparation moringa oleifera leaf extractive: take leaf of Moringa, puts into volume and is leaf of Moringa volume 5 times and the water that temperature is 15 DEG C floods, flood after 40 minutes by leaf of Moringa, collect leaf of Moringa leachate, remove insoluble substance, filter, obtain moringa oleifera leaf extractive;
Step 2: take Fructus Arctii, Radix Notoginseng, Herba Taraxaci, Fructus Foeniculi, Folium Ginkgo, Flos Carthami, Fructus Crataegi, Fructus Corni, Herba Cistanches, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Rhodobryum roseum Limpr. and Radix Glycyrrhizae, add 4 times amount water soaking 3 hours, intense fire decocts boiling 30 minutes, use slow fire boiling again 1.5 hours, filter, obtain filtrate, 4 times of water gagings are added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling again 1.5 hours, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.20, add the moringa oleifera leaf extractive that step one obtains, drying under reduced pressure, 100 mesh sieves are crossed after pulverizing, obtain Chinese medicine composition of the present invention.Add starch, water and rubber cement, mixing, stirs, is pressed into thin slice, be ground into granule, obtain the embodiment of the present invention 2 Chinese medicinal composition granules.
embodiment 3:
The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 10 parts, Fructus Arctii 10 parts, Radix Notoginseng 6 parts, Herba Taraxaci 12 parts, 12 parts, Fructus Foeniculi, Folium Ginkgo 7 parts, 6 parts, Flos Carthami, Fructus Crataegi 10 parts, Fructus Corni 9 parts, Herba Cistanches 9 parts, Radix Aconiti Lateralis Preparata 9 parts, Radix Ginseng 6 parts, Radix Ophiopogonis 10 parts, Rhodobryum roseum Limpr. 7 parts and 9 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: preparation moringa oleifera leaf extractive: take leaf of Moringa, puts into volume and is leaf of Moringa volume 15 times and the water that temperature is 5 DEG C floods, flood after 40 minutes by leaf of Moringa, collect leaf of Moringa leachate, remove insoluble substance, filter, obtain moringa oleifera leaf extractive;
Step 2: take Fructus Arctii, Radix Notoginseng, Herba Taraxaci, Fructus Foeniculi, Folium Ginkgo, Flos Carthami, Fructus Crataegi, Fructus Corni, Herba Cistanches, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Rhodobryum roseum Limpr. and Radix Glycyrrhizae, add 5 times amount water soaking 1 hour, intense fire decocts boiling 30 minutes, use slow fire boiling again 1 hour, filter, obtain filtrate, 5 times of water gagings are added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling again 1 hour, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.35, add the moringa oleifera leaf extractive that step one obtains, drying under reduced pressure, 120 mesh sieves are crossed after pulverizing, obtain Chinese medicine composition of the present invention.Add starch, water and rubber cement, mixing, stirs, is pressed into thin slice, be ground into granule, obtain the embodiment of the present invention 3 Chinese medicinal composition granules.
embodiment 4:
The embodiment of the present invention 4 Chinese medicine composition is prepared from by the raw material of following parts by weight: leaf of Moringa 12 parts, Fructus Arctii 12 parts, Radix Notoginseng 8 parts, Herba Taraxaci 13 parts, 14 parts, Fructus Foeniculi, Folium Ginkgo 9 parts, 8 parts, Flos Carthami, Fructus Crataegi 10 parts, Fructus Corni 11 parts, Herba Cistanches 11 parts, Radix Aconiti Lateralis Preparata 6 parts, Radix Ginseng 7 parts, Radix Ophiopogonis 7 parts, Rhodobryum roseum Limpr. 7 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: preparation moringa oleifera leaf extractive: take leaf of Moringa, puts into volume and is leaf of Moringa volume 8 times and the water that temperature is 8 DEG C floods, flood after 50 minutes by leaf of Moringa, collect leaf of Moringa leachate, remove insoluble substance, filter, obtain moringa oleifera leaf extractive;
Step 2: take Fructus Arctii, Radix Notoginseng, Herba Taraxaci, Fructus Foeniculi, Folium Ginkgo, Flos Carthami, Fructus Crataegi, Fructus Corni, Herba Cistanches, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Rhodobryum roseum Limpr. and Radix Glycyrrhizae, add 6 times amount water soaking 3 hours, intense fire decocts boiling 30 minutes, use slow fire boiling again 2 hours, filter, obtain filtrate, 5 times of water gagings are added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling again 2 hours, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.30, add the moringa oleifera leaf extractive that step one obtains, drying under reduced pressure, 120 mesh sieves are crossed after pulverizing, obtain Chinese medicine composition of the present invention.Add starch, water and rubber cement, mixing, stirs, is pressed into thin slice, be ground into granule, obtain the embodiment of the present invention 4 Chinese medicinal composition granules.
clinical observation on the therapeutic effect
1 case selection: in 500 routine myocardial infarction clinical volunteers patients, male patient 300 example, female patient 200 example, age bracket is 40-69 year, mean age is 54.5 years old, and all patients all has typical myocardial infarction and faces symptom, and in sex, age, the course of disease no difference of science of statistics.
2 diagnostic criterias:
(1) typical myocardial ischemia symptom (chest pain or discomfort uncomfortable in chest);
(2) typical cardiac electrical figure change;
(3) Serum fibrosis markers raises.
3 efficacy assessment standards:
Cure: after drug administration, malaise symptoms disappears completely;
Effective: after drug administration, malaise symptoms alleviates or partial disappearance;
Invalid: after drug administration, malaise symptoms is unchanged;
4 instructions of taking: 500 patients are divided into 5 groups at random, often organize 100 people, be respectively treatment A group, treatment B group, treatment C group, treatment D group and matched group, treatment A group, treatment B group, treatment C group, treatment D group take the granule (0.3g*10 bag/box) that the embodiment of the present invention 1,2,3,4 prepares respectively, every day 3 times, each 1-2 bag, serve on 1 month.Matched group takes FUFANG DANSHEN DIWAN (Tianjin Tasly Pharmaceutical Co., Ltd, the accurate word Z10950111 of traditional Chinese medicines), oral or sublingual administration, and 10 balls, 3 times on the one 4 weeks is a course for the treatment of.
5 therapeutic outcomes: as shown in table 1.
table 1 therapeutic outcome
This test adopts FUFANG DANSHEN DIWAN as a control group, FUFANG DANSHEN DIWAN has blood circulation promoting and blood stasis dispelling, effect of regulating QI to relieve pain, by comparing with the therapeutic effect of Chinese medicine composition of the present invention, can find out the curative effect of traditional Chinese medicine composition for treating myocardial infarction aspect of the present invention.Make inventor surprisingly, the cure rate of Chinese medicine composition of the present invention reaches more than 80.0%, total effective rate reaches more than 90.0%, far above cure rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of C group, visible, the good effect of Chinese medicine composition of the present invention, cure rate is high, can be used as the drug use for the treatment of myocardial infarction.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (7)
1. treat a Chinese medicine composition for myocardial infarction, it is characterized in that being prepared from by the raw material of following weight portion: leaf of Moringa 3-15 part, Fructus Arctii 6-15 part, Radix Notoginseng 3-9 part, Herba Taraxaci 9-15 part, Fructus Foeniculi 6-15 part, Folium Ginkgo 3-10 part, Flos Carthami 3-9 part, Fructus Crataegi 9-12 part, Fructus Corni 6-12 part, Herba Cistanches 6-12 part, Radix Aconiti Lateralis Preparata 3-15 part, Radix Ginseng 3-9 part, Radix Ophiopogonis 3-15 part, Rhodobryum roseum Limpr. 6-9 part and Radix Glycyrrhizae 1-10 part.
2. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 1, is characterized in that being prepared from by the raw material of following weight portion: leaf of Moringa 3 parts, Fructus Arctii 6 parts, Radix Notoginseng 3 parts, Herba Taraxaci 9 parts, 6 parts, Fructus Foeniculi, Folium Ginkgo 3 parts, 3 parts, Flos Carthami, Fructus Crataegi 9 parts, Fructus Corni 6 parts, Herba Cistanches 6 parts, Radix Aconiti Lateralis Preparata 3 parts, Radix Ginseng 3 parts, Radix Ophiopogonis 3 parts, Rhodobryum roseum Limpr. 6 parts and 1 part, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 1, is characterized in that being prepared from by the raw material of following weight portion: leaf of Moringa 15 parts, Fructus Arctii 15 parts, Radix Notoginseng 9 parts, Herba Taraxaci 15 parts, 15 parts, Fructus Foeniculi, Folium Ginkgo 10 parts, 9 parts, Flos Carthami, Fructus Crataegi 12 parts, Fructus Corni 12 parts, Herba Cistanches 12 parts, Radix Aconiti Lateralis Preparata 15 parts, Radix Ginseng 9 parts, Radix Ophiopogonis 15 parts, Rhodobryum roseum Limpr. 9 parts and 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 1, is characterized in that being prepared from by the raw material of following weight portion: leaf of Moringa 10 parts, Fructus Arctii 10 parts, Radix Notoginseng 6 parts, Herba Taraxaci 12 parts, 12 parts, Fructus Foeniculi, Folium Ginkgo 7 parts, 6 parts, Flos Carthami, Fructus Crataegi 10 parts, Fructus Corni 9 parts, Herba Cistanches 9 parts, Radix Aconiti Lateralis Preparata 9 parts, Radix Ginseng 6 parts, Radix Ophiopogonis 10 parts, Rhodobryum roseum Limpr. 7 parts and 9 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 1, is characterized in that: described Chinese medicine composition is oral formulations.
6. the Chinese medicine composition for the treatment of myocardial infarction as claimed in claim 5, is characterized in that: described oral formulations is tablet, capsule, drop pill, granule, powder or oral liquid.
7. prepare as arbitrary in claim 1-6 as described in the method for Chinese medicine composition for the treatment of myocardial infarction, it is characterized in that comprising following processing step:
Step one: preparation moringa oleifera leaf extractive: take leaf of Moringa, leaf of Moringa is put into volume be leaf of Moringa volume 1-20 doubly and the water that temperature is 5-20 DEG C flood, flood after 30-60 minute, collect leaf of Moringa leachate, remove insoluble substance, filter, obtain moringa oleifera leaf extractive;
Step 2: take Fructus Arctii, Radix Notoginseng, Herba Taraxaci, Fructus Foeniculi, Folium Ginkgo, Flos Carthami, Fructus Crataegi, Fructus Corni, Herba Cistanches, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Rhodobryum roseum Limpr. and Radix Glycyrrhizae, add 3-8 times amount water soaking 1-3 hour, intense fire decocts boiling 30 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, 2-5 times of water gaging is added in filtering residue, intense fire decocts boiling 15 minutes, use slow fire boiling 1-2 hour again, filter, obtain filtrate, merge twice filtrate, filtrate is concentrated into the thick paste that relative density is 1.20-1.35, add the moringa oleifera leaf extractive that step one obtains, drying under reduced pressure, 100-120 mesh sieve is crossed after pulverizing, obtain Chinese medicine composition of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510442919.0A CN104940597A (en) | 2015-07-27 | 2015-07-27 | Chinese herbal composition used for treating myocardial infarction, and preparation method of Chinese herbal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510442919.0A CN104940597A (en) | 2015-07-27 | 2015-07-27 | Chinese herbal composition used for treating myocardial infarction, and preparation method of Chinese herbal composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104940597A true CN104940597A (en) | 2015-09-30 |
Family
ID=54156021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510442919.0A Withdrawn CN104940597A (en) | 2015-07-27 | 2015-07-27 | Chinese herbal composition used for treating myocardial infarction, and preparation method of Chinese herbal composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104940597A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232677A (en) * | 2015-10-10 | 2016-01-13 | 临沂草之美医药科技有限公司 | Traditional Chinese medicine composition for treating myocardial infarction and preparation method of traditional Chinese medicine composition |
| CN105311426A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Pharmaceutical composition containing folium artemisiae argyi for treating myocardial infarction and preparation method of pharmaceutical composition |
| CN105749091A (en) * | 2016-02-23 | 2016-07-13 | 宋云飞 | Medicine used for curing ischemic heart disease myocardial infarction |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356138A (en) * | 2001-09-27 | 2002-07-03 | 孔金立 | Medicine for treating cardiovascular and cerebrovascular diseases of old people |
| CN1772196A (en) * | 2005-11-08 | 2006-05-17 | 吴家录 | Heart failure regulating Chinese medicine |
| CN101104048A (en) * | 2006-07-14 | 2008-01-16 | 黄振华 | Compound medicine for pulse generating and treating coronary heart disease |
| CN101632784A (en) * | 2008-07-21 | 2010-01-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating acute myocardial infarction |
| CN103784934A (en) * | 2014-03-13 | 2014-05-14 | 崔新明 | Pharmaceutical composition for preventing and curing acute myocardial infarction and application thereof |
| CN103784820A (en) * | 2014-02-23 | 2014-05-14 | 曹小松 | Traditional Chinese medicine formula for treating cariac blood stasis type coronary heart disease |
| CN103816280A (en) * | 2014-03-25 | 2014-05-28 | 崔新明 | Traditional Chinese medicine composition for treating myocardial infarction and application of traditional Chinese medicine composition |
-
2015
- 2015-07-27 CN CN201510442919.0A patent/CN104940597A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356138A (en) * | 2001-09-27 | 2002-07-03 | 孔金立 | Medicine for treating cardiovascular and cerebrovascular diseases of old people |
| CN1772196A (en) * | 2005-11-08 | 2006-05-17 | 吴家录 | Heart failure regulating Chinese medicine |
| CN101104048A (en) * | 2006-07-14 | 2008-01-16 | 黄振华 | Compound medicine for pulse generating and treating coronary heart disease |
| CN101632784A (en) * | 2008-07-21 | 2010-01-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating acute myocardial infarction |
| CN103784820A (en) * | 2014-02-23 | 2014-05-14 | 曹小松 | Traditional Chinese medicine formula for treating cariac blood stasis type coronary heart disease |
| CN103784934A (en) * | 2014-03-13 | 2014-05-14 | 崔新明 | Pharmaceutical composition for preventing and curing acute myocardial infarction and application thereof |
| CN103816280A (en) * | 2014-03-25 | 2014-05-28 | 崔新明 | Traditional Chinese medicine composition for treating myocardial infarction and application of traditional Chinese medicine composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232677A (en) * | 2015-10-10 | 2016-01-13 | 临沂草之美医药科技有限公司 | Traditional Chinese medicine composition for treating myocardial infarction and preparation method of traditional Chinese medicine composition |
| CN105796685A (en) * | 2015-10-10 | 2016-07-27 | 烟台市蓝洋之草医药生物科技有限公司 | Method for preparing traditional Chinese medicine composition for treating myocardial infarction |
| CN105311426A (en) * | 2015-11-18 | 2016-02-10 | 暨南大学 | Pharmaceutical composition containing folium artemisiae argyi for treating myocardial infarction and preparation method of pharmaceutical composition |
| CN105749091A (en) * | 2016-02-23 | 2016-07-13 | 宋云飞 | Medicine used for curing ischemic heart disease myocardial infarction |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104873947A (en) | Medicinal composition for treating dog acute upper gastrointestinal hemorrhage and preparation method thereof | |
| CN104971215A (en) | Traditional Chinese medicine composition for treating spleen-deficiency gastrasthenia type chronic gastritis and preparation method thereof | |
| CN104958646A (en) | Chinese medicinal preparation for relaxing bowels and preparation method thereof | |
| CN104940597A (en) | Chinese herbal composition used for treating myocardial infarction, and preparation method of Chinese herbal composition | |
| CN105663656A (en) | Pharmaceutical composition for treating sleep disorders and preparing method thereof | |
| CN104687198A (en) | Health beverage with Qi tonifying and nerve soothing effects and preparing method | |
| CN104353051A (en) | Traditional Chinese medicine preparation for treating stomachache and preparation method thereof | |
| CN105232677A (en) | Traditional Chinese medicine composition for treating myocardial infarction and preparation method of traditional Chinese medicine composition | |
| CN113209194A (en) | Composition for treating chronic gastritis and preparation method and application thereof | |
| CN105362914A (en) | Traditional Chinese medicinal composition for treating chronic gastritis | |
| CN104984027A (en) | Chinese materia medica preparation for treating myelodysplastic syndrome and preparation method thereof | |
| CN104784476A (en) | Traditional Chinese medicine capsule for treating arrhythmia and preparation method | |
| CN105213769A (en) | A kind of Chinese medicine composition for the treatment of myocardial infarction and preparation method thereof | |
| CN105709005A (en) | Breast rehabilitation promoting pill | |
| CN105770760A (en) | Preparation for treating gastric ulcer and preparation method thereof | |
| CN105148067A (en) | Traditional Chinese medicine composition for treating tumors | |
| CN106806680A (en) | Raw white side's prepared slices of Chinese crude drugs combination preparation, preparation method and assembly packaging | |
| CN104906265A (en) | Traditional Chinese medicine composition for treating coronary heart disease | |
| CN105726707A (en) | Heart and spleen tonifying preparation for treating rheumatic heart disease | |
| CN104800792A (en) | Traditional Chinese medicine preparation for treating reflux esophagitis and preparation method thereof | |
| CN104689205A (en) | Traditional Chinese preparation for treating insomnia and dreamful sleep and preparation method thereof | |
| CN105288036A (en) | Pharmaceutical composition for treating myocardial infarction and preparing method thereof | |
| CN103623271B (en) | A kind of preparation method of eight-ingredient stomach-regulating oral formulations | |
| CN105056010A (en) | Agentia for treating arrhythmia and making method | |
| CN108452230A (en) | A kind of composition and preparation method thereof of tranquilization and refreshment intelligence development |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gong Piju Inventor after: Liu Huantao Inventor before: Zhu Kongxi |
|
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20150930 |