CN104906265A - Traditional Chinese medicine composition for treating coronary heart disease - Google Patents
Traditional Chinese medicine composition for treating coronary heart disease Download PDFInfo
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- CN104906265A CN104906265A CN201510361756.3A CN201510361756A CN104906265A CN 104906265 A CN104906265 A CN 104906265A CN 201510361756 A CN201510361756 A CN 201510361756A CN 104906265 A CN104906265 A CN 104906265A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating a coronary heart disease. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: 10-17 parts of platycodon grandiflorum, 9-15 parts of folium ginkgo, 7-12 parts of egg white, 9-11 parts of myrrh, 11-15 parts of ziziphora clinopodioides lam, 8-16 parts of fructus trichosanthis, 6-12 parts of carthamus seeds, 11-16 parts of cassia twig, 9-14 parts of long pepper, 12-16 parts of Chinese hawthorn leaves, 13-20 parts of ginseng, 8-17 parts of horseradish roots, 10-15 parts of polygala tenuifolia, 9-13 parts of sunflower seeds and 7-11 parts of Japanese polygala. Through dilating crown, decreasing the heart rate, improving myocardium support and reducing oxygen consumption of myocardium, the traditional Chinese medicine composition is capable of effectively reliving symptoms; and the traditional Chinese medicine composition has the effects of regulating vital energy, relieving pain, dredging collaterals, reducing swelling, activating blood circulation, removing stasis, strengthening the body resistance and nourishing the heart, and is significant in curative effect on the coronary heart disease.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition for the treatment of coronary heart disease.
Background technology
Coronary heart disease is the abbreviation of coronary heart disease, a kind of modal heart disease, coronary atherosclerotic heart disease is coronary artery generation atherosclerotic lesion and causes lumen of vessels stenosis or occlusion, cause myocardial ischemia, anoxia or downright bad and heart disease that is that cause, be usually called as " coronary heart disease ".But the scope of coronary heart disease may be more extensive, also comprises inflammation, thromboembolism etc. and cause luminal stenosis or obturation.Coronary heart disease is divided into 5 large classes by World Health Organization (WHO): silent ischemia (latent coronary heart disease), angina pectoris, myocardial infarction, ischemic heart failure (ischemic heart desease) and sudden death 5 kinds of Clinical types.Stable coronary heart disease and acute coronary syndrome is usually divided in clinical.
The generation of coronary heart disease and the degree of coronary atherosclerosis and number have substantial connection, suffer from the disease such as hypertension, diabetes, and obesity, bad life habits etc. are the principal elements of bringing out this disease simultaneously.Coronary heart disease is one of disease that global mortality rate is the highest, and according to World Health Organization's report of 2011, the coronary heart disease death number of China arranges second place of the world.Pathogenesis: due to abnormalities of sugar/lipid metabolism, lipid in blood is calm on the endarterium of otherwise smooth, pile up at the lipid material of some similar medicated porridge samples of endarterium and form white speckle, these specklees gradually increase and cause lumen of artery narrow, blood flow is obstructed, cause heart ischemia, produce angina pectoris.If the Mottling formation ulcer on arterial wall or break, will thrombosis be formed, whole vascular flow is interrupted completely, acute myocardial infarction occur, even dies suddenly.The rare pathogenesis of coronary heart disease is coronary vasospasm (blood vessel can not have atherosis), produces ariant angina, if spasm was more than 30 minutes, acute myocardial infarction also can be caused even to die suddenly.
The method of existing Chinese traditional treatment coronary heart disease is a lot, publication number CN 103656168 A (application number 201210361240.5) patent document discloses a kind of Chinese medicine preparation for the treatment of coronary heart disease, be made up of the raw material of Chinese medicine of following weight: Radix Ginseng 10-30g, Radix Ophiopogonis 10-20g, Fructus Schisandrae Chinensis 3-15g.Publication number CN 103393934 A(application number 201310342314.5) patent document discloses a kind of medicine for the treatment of coronary heart disease, it forms by following mass fraction preparation of raw material: Rhizoma Corydalis 30-50g, Rhizoma Corydalis 30-50g, Rhizoma Cyperi 25-45g, Radix Astragali 35-45g, Flos Tulipae Gesnerianae 20-40g, Radix Puerariae 25-45g, Pollen Typhae 30-50g, Radix Salviae Miltiorrhizae 25-35g, Radix Paeoniae Rubra 25-35g, Rhizoma Alismatis 20-40g, Pheretima 15-25g, Fructus Trichosanthis 25-35g, Herba Ocimi (Herba Ocimi Pilosi) 25-35g, Folium Ginkgo 15-25g, Radix Rhodiolae 15-25g, Rhizoma Polygonati 15-25g, Caulis Perillae 35-55g, Sanguis Draxonis 25-35g, Radix Angelicae Sinensis 25-45g, Rhizoma Chuanxiong 30-50g, Flos Carthami 25-45g, Herba Saussureae Involueratae 1525g, Venenum Bufonis 15-25g, Pheretima 15-25g, Scorpio 15-25g, Herba Erigerontis 25-35g, Fructus Tribuli 15-25g.Publication number CN 103990049 A (application number 201410274863.8) patent document discloses a kind of Chinese medicine for the treatment of coronary heart disease, be made up of the crude drug of following weight portion, Radix Ilicis Pubescentis 20-40 part, lip Rhizoma et radix valerianae 7-13 part, Rhodobryum roseum Limpr. 5-7 part, Fuscoporia punctata(Fr.)Cum. 10-20 part, Semen Cassiae 12-18 part, Herba Euphorbiae Humifusae 10-20 part, Rhizoma Et Radix Notopterygii 12-18 part, PINGDIMU 6-14 part, Styrax 15-25 part, Rhizoma Acori Graminei 10-20 part, Radix Fimbristylis rigidulae 15-25 part, Radix Bupleuri 10-20 part, Herba Ipomoeae Cairicae 12-18 part, Semen Lepidii (Semen Descurainiae) 15-25 part, Zornia diphylla (Linn.) Pers. 5-13 part, full Chinese juniper beach wormwood 8-16 part, Cortex Eucommiae 15-25 part, Radix Cynanchi Paniculati 15-25 part, Semen Alpiniae Katsumadai 15-25 part, above-mentioned 19 kinds of crude drug are soaked in water, to remove slag after decocting to obtain filtrate.
At present, the specific drug of coronary heart disease is not treated in doctor trained in Western medicine aspect, mainly with the medicine adopting coronary dilating and decreased heart rate, although can alleviate disease to a certain extent, just respite, can not cure, side effect is large, and life-time service can produce untoward reaction, causes hepatorenal damage.Most of patients often needs to carry out interventional therapy by operation, but operative treatment just means larger risk and longer post-operative recovery time.
Summary of the invention
For the deficiency of existing treatment coronary heart disease, an object of the present invention is to provide a kind of Chinese medicine composition for the treatment of coronary heart disease, has regulating QI to relieve pain, an effect that dredging collateral detumescence, blood circulation promoting and blood stasis dispelling, righting are nourished heart.Another object is just to provide the preparation method of the Chinese medicine composition of above-mentioned treatment coronary heart disease.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Chinese medicine composition for the treatment of coronary heart disease, takes off the primary raw material stating weight proportion and is prepared from: Radix Platycodonis 10-17 part; Folium Ginkgo 9-15 part; Ovum Gallus domesticus album 7-12 part; Myrrha 9-11 part; Lip Rhizoma et radix valerianae 11-15 part; Fructus Trichosanthis 8-16 part; Fructus Carthami tinctorii 6-12 part; Ramulus Cinnamomi 11-16 part; Fructus Piperis Longi 9-14 part; Folium Crataegi 12-16 part; Radix Ginseng 13-20 part; Radix Cochleariae officinalis grass 8-17 part; Radix Polygalae 10-15 part; Semen Helianthi 9-13 part; Herba Polygalae Japonicae 7-11 part.
The Chinese medicine composition for the treatment of coronary heart disease, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Platycodonis 13-15 part; Folium Ginkgo 11-13 part; Ovum Gallus domesticus album 9-11 part; Myrrha 9.5-10.5 part; Lip Rhizoma et radix valerianae 12-14 part; Fructus Trichosanthis 11-13 part; Fructus Carthami tinctorii 8-10 part; Ramulus Cinnamomi 13-15 part; Fructus Piperis Longi 11-13 part; Folium Crataegi 13-15 part; Radix Ginseng 16-18 part; Radix Cochleariae officinalis grass 12-14 part; Radix Polygalae 12-14 part; Semen Helianthi 10-12 part; Herba Polygalae Japonicae 8-10 part.
The Chinese medicine composition for the treatment of coronary heart disease, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Platycodonis 14 parts; Folium Ginkgo 12 parts; Ovum Gallus domesticus album 10 parts; Myrrha 10 parts; Lip Rhizoma et radix valerianae 13 parts; Fructus Trichosanthis 12 parts; Fructus Carthami tinctorii 9 parts; Ramulus Cinnamomi 14 parts; Fructus Piperis Longi 12 parts; Folium Crataegi 14 parts; Radix Ginseng 17 parts; Radix Cochleariae officinalis grass 13 parts; Radix Polygalae 13 parts; Semen Helianthi 11 parts; Herba Polygalae Japonicae 9 parts.
Present invention also offers the preparation method Chinese medicine composition of above-mentioned treatment coronary heart disease being made pharmaceutically acceptable oral liquid, granule, capsule, tablet and pill.
The preparation method of the Chinese medicine composition oral liquid of described treatment coronary heart disease, step is as follows:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) cut into slices by Rhizoma Zingiberis Recens, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak 20-30 minute (preferably soak 23-27 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, (consumption of preferred xylitol is the 7%-9% of quality of liquid medicine to add xylitol, the consumption being more preferably xylitol is 8% of quality of liquid medicine), mix homogeneously, high temperature sterilization 30-40 minute (preferred high temperature sterilization 33-37 minute, be more preferably high temperature sterilization 35 minutes), carry out sterile packaged with the specification of often propping up 6ml.
According to preparation method recited above, preferred scheme is: the consumption of the preferred Rhizoma Zingiberis Recens of step (2) is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, and the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass.
Instructions of taking: each 1, every day 3 times, 7 days courses for the treatment of.
The preparation method of the Chinese medicinal composition granules of described treatment coronary heart disease, step is as follows:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), add starch, mix homogeneously, make uniform fine particle, with the specification sterile packaged of every parcel 6g.
According to preparation method recited above, preferred scheme is: the consumption of step (5) preferred starch is the 10%-20% of thick paste quality, and the consumption being more preferably starch is 15% of thick paste quality.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 7 days courses for the treatment of.
The preparation method of the Chinese medicinal composition capsules of described treatment coronary heart disease, step is as follows:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), dry, pulverize, obtain medicated powder, make capsule by the specification of 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain).
Using method: each 1-2 grain, every day 3 times, 7 days courses for the treatment of.
The preparation method of the Chinese medicine composition tablet of described treatment coronary heart disease, step is as follows:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make uniform granule, dry, be pressed into lamellar, sugar coating.
Instructions of taking: each 1-2 sheet, every day 3 times, 7 days courses for the treatment of.
The preparation method of the Chinese medicine composition pill of described treatment coronary heart disease, step is as follows:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.10-1.20(40 DEG C) thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 8-12 ball, every day 3 times, 7 days courses for the treatment of.
Beneficial effect of the present invention is mainly reflected in:
1, the Chinese medicine composition that the present invention treats coronary heart disease adopts that common Chinese medicine material is refining to be formed, and has regulating QI to relieve pain, an effect that dredging collateral detumescence, blood circulation promoting and blood stasis dispelling, righting are nourished heart.
2, the present invention is by coronary dilating and decreased heart rate, improves cardiac muscle and supports and reduce myocardial oxygen consumption, thus effective relief of symptoms, reduce anginal outbreak and myocardial infarction, delay the development of coronary heart disease.
3, raw material of the present invention mostly is common medical material, has no side effect, and cost is low, significantly reduces the financial burden of patient.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
The pharmacological effect of each crude drug is respectively:
Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.For the dry root of Campanulaceae Radix Platycodonis.There is lung qi dispersing, sore-throat relieving, eliminate the phlegm, effect of evacuation of pus.For cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Folium Ginkgo: sweet in the mouth, hardship, puckery, property is put down.GUIXIN, lung meridian.For the dried leaves of Ginkgoaceae plant Ginkgo biloba.Have and astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, effect of pain relieving.For cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, hyperlipemia.
Ovum Gallus domesticus album: sweet in the mouth, property is put down.Return spleen, stomach warp.For the albumen of Phasianidae animal man chicken.There is moistening lung and nourishing throat, heat-clearing and toxic substances removing, tonifying the lung nourish blood, nourshing Yin and drynsessmoistening prescription effect.For insufficiency of vital energy and blood, calentura excessive thirst, frequent fetal movement, nourishing YIN benefit blood, relieving restlessness is calmed the nerves, spleen reinforcing stomach function regulating, and the milk caused by blood deficiency reduces, or dizzy, nyctalopia, body is empty after being ill, malnutrition, deficiency of YIN-blood, insomnia is irritated, cardiopalmus, and lung stomach-Yin is hindered, aphonia pharyngalgia, or vomiting, pharyngalgia, conjunctival congestion, cough with dyspnea, malaria, burn, pyretic toxicity swells and ache.
Myrrha: bitter in the mouth, pungent, property is put down.For olive subject plant Herba Violae tree or the dry resin of Ha Didingshu.Gather the white oleo-gum-resin of being oozed out by bark crack, in air, become rufous and hard nahlock.After smashing, fry to coke black and apply.There is promoting blood circulation and stopping pain, effect of detumescence and promoting granulation.For breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.Be in the Orient a kind ofly to invigorate blood circulation, blood stasis dispelling, pain relieving, stomach invigorating Chinese medicine.
Lip Rhizoma et radix valerianae: acrid in the mouth, cool in nature.For the Herb of labiate lip Rhizoma et radix valerianae.Containing flavone: gloomy rhinoceros grass element, obscure flower glycoside, 7-methyl 5,7,4'-trihydroxy-6,8,3'-trimethoxyflavone, chrysin-7-O-rutinoside and caffeic acid, 4-hydroxyl-3,5-dimethoxy p-methyl, oleanolic acid, daflon.There is mind tranquilizing and the heart calming, effect of diuretic heat clearing away.For cardiopalmus, insomnia, edema, cold, fever, conjunctival congestion and swelling pain, sore swollen toxin.
Fructus Trichosanthis: sweet in the mouth, bitter in the mouth, cold in nature.Return lung, stomach, large intestine channel.For the mature fruit of Cucurbitaceae herbaceous perennial vine Trichosanthes kirilowii or trichosanthes rosthornii Harms.Fructus Trichosanthis master is containing triterpene saponin.The fatty oil of seed, saponin.Pericarpium Trichosanthis is containing several amino acids and alkaloid etc.Peel contains three circle Saponins, organic acid, resin, saccharide and pigment.The fatty oil of seed about 26%.There is removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, effect of loosening bowel to relieve constipation.For phlegm-heat cough, lung abscess vomiting pus, thoracic obstruction hypochondriac pain, blocked-up chest, acute mastitis, dryness of the intestine constipation etc.
Fructus Carthami tinctorii: sweet in the mouth, hot in nature.For the fruit of feverfew Flos Carthami.Seed oil-containing 30.2%, kernel oil-containing 45-49%, containing linoleic acid 73.6-78.0%, oleic acid 12.0-15.2% in seed oil, and myristic acid, Palmic acid, stearic acid, palmitoleic acid; The kernel deoiled is containing protein 61.5-63.4%.There is promoting blood circulation and detoxication, preventing phlegm from forming and stopping coughing, tonneau intestinal, except Yu Yangxin, effect of dispelling wind for relieving itching.Go out unhappy for pox, the stagnant stomachache of women's vim and vigour stasis of blood, abundant expectoration is coughed, constipation, intestinal angor, depression, cardiopalmus, leprosy, skin pruritus.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.For the dry twig of canella Cortex Cinnamomi.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, effect of the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Fructus Piperis Longi: acrid in the mouth, hot in nature.Return stomach, large intestine channel.The nearly ripe or mature fruit cluster of drying for Piperaceae plant Fructus Piperis Longi.There is warming spleen and stomach for dispelling cold, effect of therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, migraine; External treatment is had a toothache.
Folium Crataegi: sour in the mouth, property is put down.Return Liver Channel.For the dried leaves of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.There is blood circulation promoting and blood stasis dispelling, effect of promoting blood circulation of regulating the flow of vital energy.For qi depression to blood stasis. chest distress, palpitation and amnesia, vertigo and tinnitus.
Radix Ginseng: sweet in the mouth, micro-hardship, property is put down.Return spleen, lung, heart channel.For the dry root and rhizome of Araliaceae Radix Ginseng.Have strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, the effect of calming the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness void is won, and palpitation with fear insomnia, positive layer official is cold, heart failure, cardiogenic shock.
Radix Cochleariae officinalis grass: acrid in the mouth, warm in nature.For root and the stem of thymelaeceae daphne plant Radix seu Cortex Daphnes koreanae.Containing daphnetin.There is warming spleen and stomach for dispelling cold, effect of blood stasis expelling pain relieving.For coronary heart disease, angina pectoris, artery chronic blood supply is incomplete, thromboangiitis obliterans, optimum arthralgia, trusted subordinate's cold type of pain, anti-frostbite.
Radix Polygalae: bitter in the mouth, pungent, warm in nature.GUIXIN, kidney, lung meridian.For the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.There is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, effect of detumescence.The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Semen Helianthi: sweet in the mouth, property is put down.For the seed of feverfew Helianthi.Fatty oil can reach about 50%, in have volume linoleic acid to reach 70%, still have the sterol such as phospholipid, cupreol.In kernel, the major part (58%) of sugar is monosaccharide and disaccharide and the trisaccharide of solubility, not starch-containing, still containing the organic acid such as citric acid, tartaric acid, chlorogenic acid, quininic acid, caffeic acid and beta-carotene, phytin., 3,4-benzene a pair of horses going side by side pyrenes.There is rash, dysentery relieving, effect of saturating pus of carbuncle.Send out not saturating for rash, dysentery, chronic osteomyelitis, dysentery, impetigo, hyperlipemia, arteriosclerosis, cancer, atherosclerosis, hypertension, coronary heart disease, neurasthenia.
Herba Polygalae Japonicae: acrid in the mouth, hardship, property is put down.Return lung, stomach, heart channel.For herb or the root of milk wort Herba Polygalae Japonicae.Root is containing triterpenoid saponin, resin, fatty oil, polygalytol and tetracetate.Aerial parts containing Triterpene saponin first, second, third, fourth and Triterpene saponin I-XIX.Leaf contains astragalin, nimbecetin 3 glycoside, nimbecetin 3,7-diglucoside.Have expelling phlegm for arresting cough, dissipating blood stasis stops blooding, mind tranquilizing and the heart calming, effect of removing toxic substances and promoting subsidence of swelling.For cough with copious phlegm, traumatic injury, rheumatic arthralgia, spits blood, has blood in stool, cardiopalmus, insomnia, laryngopharynx swelling and pain, carbuncle skin infection, venom.
embodiment 1the Chinese medicine composition for the treatment of coronary heart disease, takes off and states primary raw material and be prepared from (getting 50g for every part): Radix Platycodonis 10 parts; Folium Ginkgo 9 parts; Ovum Gallus domesticus album 7 parts; Myrrha 9 parts; Lip Rhizoma et radix valerianae 11 parts; Fructus Trichosanthis 8 parts; Fructus Carthami tinctorii 6 parts; Ramulus Cinnamomi 11 parts; Fructus Piperis Longi 9 parts; Folium Crataegi 12 parts; Radix Ginseng 13 parts; Radix Cochleariae officinalis grass 8 parts; Radix Polygalae 10 parts; Semen Helianthi 9 parts; Herba Polygalae Japonicae 7 parts.
The preparation method of the Chinese medicine composition oral liquid of above-mentioned treatment coronary heart disease, step is as follows:
(1) be placed in pot by Myrrha, slow fire heats, and fries to when smoldering, spray rice vinegar (consumption is 10% of Myrrha quality), moistening 4 minutes, continues slow fire and fries 23 minutes, take out, cool, with Semen Helianthi pulverize altogether, cross 170 mesh sieves, mix with Ovum Gallus domesticus album, stir 12 minutes;
(2) by Rhizoma Zingiberis Recens (consumption is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soaks 25 minutes, slow fire heats to boil altogether to Sucus Zingberis and is sucked, take out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (preferably the hot water of 95 DEG C), soak 35 minutes, filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct 45 minutes, add step (2) gains and step (3) gained filtering residue, decoct with water 45 minutes, merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, add xylitol (consumption is 8% of quality of liquid medicine), mix homogeneously, high temperature sterilization 35 minutes, carries out sterile packaged with the specification of often propping up 6ml.
Instructions of taking: each 1, every day 3 times, 7 days courses for the treatment of.
embodiment 2the Chinese medicine composition for the treatment of coronary heart disease, takes off and states primary raw material and be prepared from (getting 40g for every part): Radix Platycodonis 17 parts; Folium Ginkgo 15 parts; Ovum Gallus domesticus album 12 parts; Myrrha 11 parts; Lip Rhizoma et radix valerianae 15 parts; Fructus Trichosanthis 16 parts; Fructus Carthami tinctorii 12 parts; Ramulus Cinnamomi 16 parts; Fructus Piperis Longi 14 parts; Folium Crataegi 16 parts; Radix Ginseng 20 parts; Radix Cochleariae officinalis grass 17 parts; Radix Polygalae 15 parts; Semen Helianthi 13 parts; Herba Polygalae Japonicae 11 parts.
The preparation method of the Chinese medicinal composition granules of above-mentioned treatment coronary heart disease, step is as follows:
(1) be placed in pot by Myrrha, slow fire heats, and fries to when smoldering, spray rice vinegar (consumption is 10% of Myrrha quality), moistening 4 minutes, continues slow fire and fries 23 minutes, take out, cool, with Semen Helianthi pulverize altogether, cross 170 mesh sieves, mix with Ovum Gallus domesticus album, stir 12 minutes;
(2) by Rhizoma Zingiberis Recens (consumption is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soaks 25 minutes, slow fire heats to boil altogether to Sucus Zingberis and is sucked, take out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (preferably the hot water of 95 DEG C), soak 35 minutes, filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct 45 minutes, add step (2) gains and step (3) gained filtering residue, decoct with water 45 minutes, merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.15(40 DEG C) thick paste, add starch, mix homogeneously, make uniform fine particle, with the specification sterile packaged of every parcel 6g.
Instructions of taking: each 1 parcel, with the warm boiled water of 35-45 DEG C, every day 3 times, 7 days courses for the treatment of.
model case one:peng XX, female, 63 years old, people from Jining City in Shandong Province.Occur precordialgia without obvious inducement several years ago, paroxysmal chest pain, vomiting, so remove examination in hospital, give the treatment such as thrombolytic, coronary dilating, symptom takes a turn for the better.In the past few years, Relapse rate shows effect, and fails to fully recover always.Recently because of chest distress, paroxysmal chest pain, pareordia dull pain, cough with asthma is coughed and is told a large amount of frothy sputum, movable difficulty, dynamic then breathe heavily very, can not put down sleeping.Check that EKG points out myocardial ischemia, lower wall old heart infarction, rabat prompting pulmonary congestion, cardiac ultrasonic prompting aortosclerosis, narrow, left heart function attenuating.Be diagnosed as coronary heart disease.
Take after the present invention treats 2 courses for the treatment of of Chinese medicine composition of coronary heart disease, patient is uncomfortable in chest to suppress to breathe heavily and alleviates, and can put down sleeping, time have cough.After continuing to take 1 course for the treatment of, symptom is obviously improved, and after patient activity, uncomfortable in chest the suppressing of micro-sense is breathed heavily, and nasal obstruction is eliminated, and various malaise symptoms is all eased.Later stage visits and learns and fully recover, and does not recur.
embodiment 3the Chinese medicine composition for the treatment of coronary heart disease, takes off and states primary raw material and be prepared from (getting 20g for every part): Radix Platycodonis 13 parts; Folium Ginkgo 11 parts; Ovum Gallus domesticus album 9 parts; Myrrha 9.5 parts; Lip Rhizoma et radix valerianae 12 parts; Fructus Trichosanthis 11 parts; Fructus Carthami tinctorii 8 parts; Ramulus Cinnamomi 13 parts; Fructus Piperis Longi 11 parts; Folium Crataegi 13 parts; Radix Ginseng 16 parts; Radix Cochleariae officinalis grass 12 parts; Radix Polygalae 12 parts; Semen Helianthi 10 parts; Herba Polygalae Japonicae 8 parts.
The preparation method of the Chinese medicinal composition capsules of above-mentioned treatment coronary heart disease, step is as follows:
(1) be placed in pot by Myrrha, slow fire heats, and fries to when smoldering, spray rice vinegar (consumption is 10% of Myrrha quality), moistening 4 minutes, continues slow fire and fries 23 minutes, take out, cool, with Semen Helianthi pulverize altogether, cross 170 mesh sieves, mix with Ovum Gallus domesticus album, stir 12 minutes;
(2) by Rhizoma Zingiberis Recens (consumption is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soaks 25 minutes, slow fire heats to boil altogether to Sucus Zingberis and is sucked, take out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (preferably the hot water of 95 DEG C), soak 35 minutes, filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct 45 minutes, add step (2) gains and step (3) gained filtering residue, decoct with water 45 minutes, merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.15(40 DEG C) thick paste, dry, pulverize, obtain medicated powder, make capsule by the specification of 0.5g/ grain.
Using method: each 1-2 grain, every day 3 times, 7 days courses for the treatment of.
embodiment 4the Chinese medicine composition for the treatment of coronary heart disease, takes off and states primary raw material and be prepared from (getting 20g for every part): Radix Platycodonis 15 parts; Folium Ginkgo 13 parts; Ovum Gallus domesticus album 11 parts; Myrrha 10.5 parts; Lip Rhizoma et radix valerianae 14 parts; Fructus Trichosanthis 13 parts; Fructus Carthami tinctorii 10 parts; Ramulus Cinnamomi 15 parts; Fructus Piperis Longi 13 parts; Folium Crataegi 15 parts; Radix Ginseng 18 parts; Radix Cochleariae officinalis grass 14 parts; Radix Polygalae 14 parts; Semen Helianthi 12 parts; Herba Polygalae Japonicae 10 parts.
The preparation method of the Chinese medicine composition tablet of above-mentioned treatment coronary heart disease, step is as follows:
(1) be placed in pot by Myrrha, slow fire heats, and fries to when smoldering, spray rice vinegar (consumption is 10% of Myrrha quality), moistening 4 minutes, continues slow fire and fries 23 minutes, take out, cool, with Semen Helianthi pulverize altogether, cross 170 mesh sieves, mix with Ovum Gallus domesticus album, stir 12 minutes;
(2) by Rhizoma Zingiberis Recens (consumption is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soaks 25 minutes, slow fire heats to boil altogether to Sucus Zingberis and is sucked, take out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (preferably the hot water of 95 DEG C), soak 35 minutes, filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct 45 minutes, add step (2) gains and step (3) gained filtering residue, decoct with water 45 minutes, merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.15(40 DEG C) thick paste, make uniform granule, dry, be pressed into lamellar, sugar coating.
Instructions of taking: each 1-2 sheet, every day 3 times, 7 days courses for the treatment of.
model case two:poplar XX, man, 53 years old, people from Jinan City, Shandong Province.Mr. Yang suffers from coronary heart disease more than ten years, often because there is chest distress after tired or anxious state of mind, then occurring precordialgia, going to hospital on inspection: thorax is tubbiness, and intercostal space is broadening, and two pulmonary respiration sound is thick, does not hear and dry, moist rale, drumstick finger.EKG points out myocardial ischemia, and cardiac ultrasonic prompting aortosclerosis, cardiac function lower.Be diagnosed as coronary heart disease, since then each uncomfortable time all can from clothes treatment coronary heart disease medicine, after taking medicine, all malaise symptoms just can reach alleviation, but again and again always, fail cure.
Take after the present invention treats 1 course for the treatment of of Chinese medicine composition of coronary heart disease, Mr. Yang leads conscious pareordia and distending pain over the hypochondrium is obviously alleviated, and coughs and accompany a small amount of white sticky expectorant time still.After continuing to take 2 courses for the treatment of, without obvious chest distress, occasionally have pareordia uncomfortable, attack times has reduced.Later stage visits and learns that all diseases disappear, and the expectorant stasis of blood is gone, does not recur.
embodiment 5the Chinese medicine composition for the treatment of coronary heart disease, takes off and states primary raw material and be prepared from (getting 20g for every part): Radix Platycodonis 14 parts; Folium Ginkgo 12 parts; Ovum Gallus domesticus album 10 parts; Myrrha 10 parts; Lip Rhizoma et radix valerianae 13 parts; Fructus Trichosanthis 12 parts; Fructus Carthami tinctorii 9 parts; Ramulus Cinnamomi 14 parts; Fructus Piperis Longi 12 parts; Folium Crataegi 14 parts; Radix Ginseng 17 parts; Radix Cochleariae officinalis grass 13 parts; Radix Polygalae 13 parts; Semen Helianthi 11 parts; Herba Polygalae Japonicae 9 parts.
The preparation method of the Chinese medicine composition pill of above-mentioned treatment coronary heart disease, step is as follows:
(1) be placed in pot by Myrrha, slow fire heats, and fries to when smoldering, spray rice vinegar (consumption is 10% of Myrrha quality), moistening 4 minutes, continues slow fire and fries 23 minutes, take out, cool, with Semen Helianthi pulverize altogether, cross 170 mesh sieves, mix with Ovum Gallus domesticus album, stir 12 minutes;
(2) by Rhizoma Zingiberis Recens (consumption is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soaks 25 minutes, slow fire heats to boil altogether to Sucus Zingberis and is sucked, take out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (preferably the hot water of 95 DEG C), soak 35 minutes, filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct 45 minutes, add step (2) gains and step (3) gained filtering residue, decoct with water 45 minutes, merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into relative density 1.15(40 DEG C) thick paste, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 7 days courses for the treatment of.
test example:in order to verify that the present invention treats the curative effect of the Chinese medicine composition of coronary heart disease, we, in May ,-2012 in March, 2010, screen 200 routine patients with coronary heart disease in Duo Suo hospital, are divided into experimental group and matched group (wherein, experimental group 150 people, matched group 50 people) at random.Experimental group takes the Chinese medicine composition pill that the present invention treats coronary heart disease, each 10 balls, every day 3 times, 7 days courses for the treatment of.Matched group: take other drug, as nitroglycerine tablets, sorbide nitrate etc., wherein nitroglycerine tablets, adult once uses 0.25-0.5mg(1 sheet) sublingual administration.Every 5 minutes can repeat 1, until pain relief.If pain lasts exists after in 15 minutes, total amount reaches 3, should seek medical advice immediately.5-10 minute preventive use before activity or stool, can avoid bringing out angina pectoris.Sorbide nitrate, a 5-10mg, 2-3 time on the one, a daily amount 10-30mg is different due to individual reaction, needs individualized adjustment dosage, sublingual administration: a 5mg, relief of symptoms.Every day, equal conditions was observed with after drug administration under the time.Curative effect situation criterion: cure: all malaise symptoms disappear, sleep and spirit are well.Effective: all malaise symptoms are eased, sleep quality is better, and the mental status is relatively good.Invalid: all malaise symptoms are without improvement.Wherein effectively comprise cure and effective.
Take the matched group of other drug and take the Comparison of therapeutic that the present invention treats the experimental group of the Chinese medicine composition of coronary heart disease, result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, take the present invention and treat the effective percentage of the Chinese medicine composition of coronary heart disease up to 96.67%, and take other drug only have 82% effective percentage, and take the present invention and treat the cure rate of the Chinese medicine composition of coronary heart disease up to 69.34%, and adopt the cure rate of other treatment scheme only to reach 40%.Experiment shows that the present invention treats the better efficacy of the Chinese medicine composition of coronary heart disease, and cure rate is high, and inefficiency is low, is the favourable agents for the treatment of coronary heart disease.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the Chinese medicine composition of coronary heart disease, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Platycodonis 10-17 part; Folium Ginkgo 9-15 part; Ovum Gallus domesticus album 7-12 part; Myrrha 9-11 part; Lip Rhizoma et radix valerianae 11-15 part; Fructus Trichosanthis 8-16 part; Fructus Carthami tinctorii 6-12 part; Ramulus Cinnamomi 11-16 part; Fructus Piperis Longi 9-14 part; Folium Crataegi 12-16 part; Radix Ginseng 13-20 part; Radix Cochleariae officinalis grass 8-17 part; Radix Polygalae 10-15 part; Semen Helianthi 9-13 part; Herba Polygalae Japonicae 7-11 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Platycodonis 13-15 part; Folium Ginkgo 11-13 part; Ovum Gallus domesticus album 9-11 part; Myrrha 9.5-10.5 part; Lip Rhizoma et radix valerianae 12-14 part; Fructus Trichosanthis 11-13 part; Fructus Carthami tinctorii 8-10 part; Ramulus Cinnamomi 13-15 part; Fructus Piperis Longi 11-13 part; Folium Crataegi 13-15 part; Radix Ginseng 16-18 part; Radix Cochleariae officinalis grass 12-14 part; Radix Polygalae 12-14 part; Semen Helianthi 10-12 part; Herba Polygalae Japonicae 8-10 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Platycodonis 14 parts; Folium Ginkgo 12 parts; Ovum Gallus domesticus album 10 parts; Myrrha 10 parts; Lip Rhizoma et radix valerianae 13 parts; Fructus Trichosanthis 12 parts; Fructus Carthami tinctorii 9 parts; Ramulus Cinnamomi 14 parts; Fructus Piperis Longi 12 parts; Folium Crataegi 14 parts; Radix Ginseng 17 parts; Radix Cochleariae officinalis grass 13 parts; Radix Polygalae 13 parts; Semen Helianthi 11 parts; Herba Polygalae Japonicae 9 parts.
4., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable oral liquid, preparation method is:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) cut into slices by Rhizoma Zingiberis Recens, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak 20-30 minute (preferably soak 23-27 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, (consumption of preferred xylitol is the 7%-9% of quality of liquid medicine to add xylitol, the consumption being more preferably xylitol is 8% of quality of liquid medicine), mix homogeneously, high temperature sterilization 30-40 minute (preferred high temperature sterilization 33-37 minute, be more preferably high temperature sterilization 35 minutes), carry out sterile packaged with the specification of often propping up 6ml.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterized in that: the consumption of the preferred Rhizoma Zingiberis Recens of step (2) is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass.
6., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), add starch, mix homogeneously, make uniform fine particle, with the specification sterile packaged of every parcel 6g.
7. the preparation method of Chinese medicine composition according to claim 6, is characterized in that: the consumption of step (5) preferred starch is the 10%-20% of thick paste quality, and the consumption being more preferably starch is 15% of thick paste quality.
8., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, be concentrated into the thick paste (be preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15) of relative density 1.10-1.20, dry, pulverize, obtain medicated powder, make capsule by the specification of 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain).
9., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make uniform granule, dry, be pressed into lamellar, sugar coating.
10., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is:
(1) Myrrha is placed in pot, slow fire heats, fry to when smoldering, (consumption of preferred rice vinegar is the 8%-12% of Myrrha quality to spray rice vinegar, the consumption being more preferably rice vinegar is 10% of Myrrha quality), moistening 3-5 minute, continuation slow fire is fried 20-25 minute (preferably continue slow fire and fry 22-24 minute, be more preferably continuation slow fire and fry 23 minutes), takes out, cool, pulverize common with Semen Helianthi, crosses 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves), mix with Ovum Gallus domesticus album, stir 10-13 minute;
(2) by Rhizoma Zingiberis Recens, (consumption of Rhizoma Zingiberis Recens is the 11%-13% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass, the consumption being more preferably Rhizoma Zingiberis Recens is 12% of Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae gross mass) section, be placed in pot, add decocting soup, add Radix Platycodonis, Radix Ginseng, Radix Cochleariae officinalis grass and Radix Polygalae, soak and (preferably soak 23-27 minute in 20-30 minute, be more preferably immersion 25 minutes), slow fire heating is boiled altogether and is sucked to Sucus Zingberis, takes out, shredding, dry;
(3) Folium Ginkgo and Folium Crataegi are placed in heatproof container, add hot water (the preferably hot water of 90 DEG C-100 DEG C, is more preferably the hot water of 95 DEG C), soak and (preferably soak 33-37 minute in 30-40 minute, be more preferably immersion 35 minutes), filter, obtain filtrate and filtering residue;
(4) lip Rhizoma et radix valerianae, Fructus Trichosanthis, Fructus Carthami tinctorii, Ramulus Cinnamomi, Fructus Piperis Longi and Herba Polygalae Japonicae are placed in marmite, add step (3) gained filtrate, decoct and (preferably decoct 43-47 minute in 40-50 minute, be more preferably decoction 45 minutes), add step (2) gains and step (3) gained filtering residue, decoct with water 40-50 minute (preferably decoct with water 43-47 minute, be more preferably and decoct with water 45 minutes), merge twice filtrate;
(5) step (1) gains are placed in step (4) gained filtrate, mixing, filter, the thick paste being concentrated into relative density 1.10-1.20 (is preferably concentrated into the thick paste of relative density 1.13-1.17, be more preferably the thick paste being concentrated into relative density 1.15), make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
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| CN107617093A (en) * | 2017-09-26 | 2018-01-23 | 广西民族大学 | A kind of Chinese medicine composition for treating coronary heart disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147401A (en) * | 1996-05-10 | 1997-04-16 | 潘兴光 | Medicine for heart disease |
| CN103611088A (en) * | 2013-12-08 | 2014-03-05 | 朱英 | Medicine for treating coronary disease and preparation method thereof |
-
2015
- 2015-06-29 CN CN201510361756.3A patent/CN104906265A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1147401A (en) * | 1996-05-10 | 1997-04-16 | 潘兴光 | Medicine for heart disease |
| CN103611088A (en) * | 2013-12-08 | 2014-03-05 | 朱英 | Medicine for treating coronary disease and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 梁湛聪: "中医对冠心病的认识和治疗", 《广州医学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107617093A (en) * | 2017-09-26 | 2018-01-23 | 广西民族大学 | A kind of Chinese medicine composition for treating coronary heart disease |
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