CN103611088A - Medicine for treating coronary disease and preparation method thereof - Google Patents
Medicine for treating coronary disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating coronary disease and a preparation method thereof. The medicine is mainly prepared from the following medicines in a certain weight ratio: radix pseudostellariae, tuber of dwarf lilyturf, schisandra chinensis, monkshood, the root of red-rooted salvia and ligusticum wallichii. The medicine has the effects of clearing away the heart-fire and tonifying spleen, calming the heart and soothing the nerves and regulating vital energy and removing stasis, is fast in effectiveness of treatment of coronary disease and good in curative effect, and the coronary disease does not reoccur.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of coronary heart disease and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Coronary heart disease is the abbreviation of coronary heart disease, is a kind of modal heart disease, refers to the myocardial dysfunction or the organic disease that because of coronary stricture, blood supply insufficiency, cause, therefore claim again ischemic cardiomyopathy.The generation of coronary heart disease and the degree of coronary atherosclerosis and number have substantial connection, suffer from the diseases such as hypertension, diabetes simultaneously, and obesity, bad life habits etc. are to bring out this sick principal element.Coronary heart disease is one of disease that global mortality rate is the highest, and according to World Health Organization's report of 2011, the coronary heart disease death number of China has been listed as second place of the world.Because Western medicine cannot effectively be treated coronary heart disease, and take Western medicine and have more side effect.Therefore, there is great demand to the Chinese medicine of rapid, effective treatment coronary heart disease in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment coronary heart disease, thereby has completed the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment coronary heart disease.
Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.
Medicine of the present invention is to select Radix Pseudostellariae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Bulbus Allii Macrostemonis, Hirudo, Radix Curcumae, Rhizoma Acori Graminei, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Cortex Albiziae, Spica Prunellae, the Radix Paeoniae Alba, Concha Ostreae, Fructus Viticis medicine to combine preparation, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat coronary heart disease.Selecting Radix Pseudostellariae is that tepor, enters the heart, spleen, lung three warps, has the function of tonifying the lung, spleen invigorating, controls cough due to deficiency of the lung because of its nature and flavor sweetness and bitterness, insufficiency of the spleen lack of appetite, and cardiopalmus order antiperspirant, spirit is tired.Select Radix Ophiopogonis to be because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, thirsty clearly, calentura Tianjin wound, dry mouth and throat, constipation.Select Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature, enters lung, kidney channel, astringes the lung, and nourishing kidney, promotes the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Rhizoma Chuanxiong to be because its nature and flavor are pungent, temperature, enters liver, gallbladder meridian, has activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the function of promoting blood circulation and stopping pain, control air-cooled headache revolve dizzy, hypochondriac pain abdomen pain, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Bulbus Allii Macrostemonis to be because its nature and flavor are arduous, temperature, enters meridian of Hand-YANG MING, regulates the flow of vital energy, and the chest stuffiness relieving, activates yang, and the function of eliminating stagnation is controlled the thorough back of the body of obstruction of qi in the chest and cardialgia, and gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.Select Hirudo to be because the salty hardship of its nature and flavor is flat, poisonous, enter liver, urinary bladder channel, have removing blood stasis, removing blood stasis, the function of stimulating the menstrual flow, controls blood-retention ， mass in the abdomen, gathers, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, conjunctival congestion with ophthalmalgia, nebula.Select Radix Curcumae to be because its nature and flavor are arduous, cool, enter the heart, lung, Liver Channel, have circulation of qi promoting solution with, the function of removing heat from blood removing blood stasis with potent drugs, controls all pains of breast abdomen side of body rib, loses the heart demented, calentura coma, spits blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select Rhizoma Acori Graminei to be because its nature and flavor are arduous, tepor, enters the heart, liver, spleen channel, has and has one's ideas straightened out, and eliminating phlegm, regulates the flow of vital energy, and invigorates blood circulation, loose wind, the function of drying, Zhi epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select Semen Ziziphi Spinosae to be because its nature and flavor are sweet, flat, enter the heart, spleen, liver, gallbladder meridian, there is nourishing the liver, mind calming, calms the nerves, and the function of arresting sweating, controls restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Select Cortex Albiziae to be because its nature and flavor are sweet, flat, enter the heart, Liver Channel, there is resolving depression, and blood, mind calming, the function of subduing inflammation, controls irritability, melancholy insomnia, lung abscess, carbuncle, scrofula, injured bone.Select Spica Prunellae to be because its nature and flavor toil is cold, enter liver, gallbladder meridian, have liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduces phlegm, the function of softening the hard mass, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Selecting Fructus Viticis is because its nature and flavor toil, cool, enters liver, stomach, and urinary bladder channel, has dispelling wind and heat pathogens, and the clear sharp head's function, controls anemopyretic cold, just, migraine, and toothache, pain in order eyeball.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight
Radix Pseudostellariae 10-20 gram of Radix Ophiopogonis 8-18 gram of Fructus Schisandrae Chinensis 5-12 gram
Radix Aconiti Lateralis Preparata 5-15 gram of Radix Salviae Miltiorrhizae 12-20 gram of Rhizoma Chuanxiong 8-18 gram
Bulbus Allii Macrostemonis 8-16 gram of Hirudo 4-8 gram of Radix Curcumae 8-15 gram
Rhizoma Acori Graminei 10-20 gram of Rhizoma Atractylodis Macrocephalae 12-25 gram of Semen Ziziphi Spinosae 25-35 gram
Cortex Albiziae 10-20 gram of Spica Prunellae 12-22 gram of Radix Paeoniae Alba 8-15 gram
Concha Ostreae 10-20 gram of Fructus Viticis 10-20 gram
Be preferably
6 grams of 10 grams of Fructus Schisandrae Chinensis of 12 grams of Radix Ophiopogonis of Radix Pseudostellariae
10 grams of 15 grams of Rhizoma Chuanxiongs of 6 grams of Radix Salviae Miltiorrhizaes of Radix Aconiti Lateralis Preparata
10 grams of 6 grams of Radix Curcumaes of 10 grams of Hirudos of Bulbus Allii Macrostemonis
30 grams of 15 grams of Semen Ziziphi Spinosaes of 12 grams of Rhizoma Atractylodis Macrocephalaes of Rhizoma Acori Graminei
10 grams of 15 grams of Radix Paeoniae Albas of 12 grams of Spica Prunellaes of Cortex Albiziae
12 grams of 15 grams of Fructus Viticises of Concha Ostreae
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Pseudostellariae: extract fibrous root, dry;
2, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
3, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
4, Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata, soak and float with clear water, change water 2-3 every day, rinses to salinity, put in pot and add water with well-done with Radix Glycyrrhizae, Semen sojae atricolor, till cutting deutostoma and tasting slightly spicy sense, take out, remove Radix Glycyrrhizae, Semen sojae atricolor, scrape peeling, be cut to two lobes, put in pot and add decocting in water 2 hours, take out, solarization is dried in the air, moistening for several times, runs through rear section repeatedly, dries, 100 jin of every Radix Aconiti Lateralis Preparata, with 5 jin, Radix Glycyrrhizae, 10 jin, Semen sojae atricolor;
5, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
6, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
7, Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;
8, stir-baked HIRUDO: get Pulvis Talci and enter in pot to make popular, put into the Hirudo of cutting, fry to slightly heaving, take out, sift out Pulvis Talci;
9, Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;
10, Rhizoma Acori Graminei: choose decontamination, clean, soak slightly, run through, section, dries;
11, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
12, Semen Ziziphi Spinosae (parched): after clean system, put in pot and stir-fry with slow fire or moderate heat heating, fry to micro-heaving, have fragrance to overflow;
13, Cortex Albiziae: clear water soak to be cleaned, and pulls out, is first divided into after moistening and equates large rectangular, then stripping and slicing or shredding, dry;
14, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
15, the Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
16, Concha Ostreae: clean, dry, pulverize use;
17, Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool.
Two, preparation
1, the Radix Pseudostellariae of described weight, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Bulbus Allii Macrostemonis, Hirudo, Radix Curcumae, Rhizoma Acori Graminei, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Cortex Albiziae, Spica Prunellae, the Radix Paeoniae Alba, Concha Ostreae, Fructus Viticis are decocted with water twice, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, filter to obtain decoction liquor for the first time.
2, the medicinal residues after filtering are for the first time added to 4 times of amounts of water, intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time.
3, merge decoction liquor twice, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 2 doses and takes.
Medicine of the present invention has the function of the relieving restlessness that clears away heart-fire, ataralgesia, the chest stuffiness relieving of regulating the flow of vital energy, and is used for the treatment of coronary heart disease instant effect, good effect.
By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment, following 18 examples of 45 years old age, 46 years old above 82 example.
2, diagnostic criteria
Coronary heart disease, i.e. coronary atherosclerotic heart disease, patient often has the coronary heart disease such as essential hypertension, hyperlipidemia, diabetes easily to suffer from factor, often shows as the symptoms such as uncomfortable in chest, nervous, anterior pectorial region pain.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, every day 2 times, each 1 dose, decoction being taken warmly, 30 days is a course for the treatment of at twice, takes continuously two courses for the treatment of.
4, efficacy assessment standard
Effective: coronary heart disease symptom recovery from illness, recovers normal;
Take a turn for the better: coronary heart disease symptom alleviates, and the state of an illness progressively takes a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy patients with coronary heart disease 100 examples of the present invention, effective 90 examples of result, obvious effective rate is 90%, 3 examples that take a turn for the better, and improvement rate is 3%, invalid 7 examples, total effective rate is 93%.
Claims (3)
1. a medicine for the treatment of coronary heart disease, is characterized in that: it is to be made by the crude drug in following weight range:
Radix Pseudostellariae 10-20 gram of Radix Ophiopogonis 8-18 gram of Fructus Schisandrae Chinensis 5-12 gram
Radix Aconiti Lateralis Preparata 5-15 gram of Radix Salviae Miltiorrhizae 12-20 gram of Rhizoma Chuanxiong 8-18 gram
Bulbus Allii Macrostemonis 8-16 gram of Hirudo 4-8 gram of Radix Curcumae 8-15 gram
Rhizoma Acori Graminei 10-20 gram of Rhizoma Atractylodis Macrocephalae 12-25 gram of Semen Ziziphi Spinosae 25-35 gram
Cortex Albiziae 10-20 gram of Spica Prunellae 12-22 gram of Radix Paeoniae Alba 8-15 gram
Concha Ostreae 10-20 gram of Fructus Viticis 10-20 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
6 grams of 10 grams of Fructus Schisandrae Chinensis of 12 grams of Radix Ophiopogonis of Radix Pseudostellariae
10 grams of 15 grams of Rhizoma Chuanxiongs of 6 grams of Radix Salviae Miltiorrhizaes of Radix Aconiti Lateralis Preparata
10 grams of 6 grams of Radix Curcumaes of 10 grams of Hirudos of Bulbus Allii Macrostemonis
30 grams of 15 grams of Semen Ziziphi Spinosaes of 12 grams of Rhizoma Atractylodis Macrocephalaes of Rhizoma Acori Graminei
10 grams of 15 grams of Radix Paeoniae Albas of 12 grams of Spica Prunellaes of Cortex Albiziae
12 grams of 15 grams of Fructus Viticises of Concha Ostreae.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Pseudostellariae: extract fibrous root, dry;
(2) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
(3) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(4) Radix Aconiti Lateralis Preparata: get Radix Aconiti Lateralis Preparata, soak and float with clear water, change water 2-3 every day, rinses to salinity, put in pot and add water with well-done with Radix Glycyrrhizae, Semen sojae atricolor, till cutting deutostoma and tasting slightly spicy sense, take out, remove Radix Glycyrrhizae, Semen sojae atricolor, scrape peeling, be cut to two lobes, put in pot and add decocting in water 2 hours, take out, solarization is dried in the air, moistening for several times, runs through rear section repeatedly, dries, 100 jin of every Radix Aconiti Lateralis Preparata, with 5 jin, Radix Glycyrrhizae, 10 jin, Semen sojae atricolor;
(5) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(6) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices after moistening, dry;
(7) Bulbus Allii Macrostemonis: choose decontamination, the sieve of winnowing with a dustpan goes whisker;
(8) stir-baked HIRUDO: get Pulvis Talci and enter in pot to make popular, put into the Hirudo of cutting, fry to slightly heaving, take out, sift out Pulvis Talci;
(9) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section, dries;
(10) Rhizoma Acori Graminei: choose decontamination, clean, soak slightly, run through, section, dries;
(11) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(12) Semen Ziziphi Spinosae (parched): after clean system, put in pot and stir-fry with slow fire or moderate heat heating, fry to micro-heaving, have fragrance to overflow;
(13) Cortex Albiziae: clear water soak to be cleaned, and pulls out, is first divided into after moistening and equates large rectangular, then stripping and slicing or shredding, dry;
(14) Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
(15) Radix Paeoniae Alba: choose decontamination, size separately, is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dry;
(16) Concha Ostreae: clean, dry, pulverize use;
(17) Fructus Viticis: well sifted ash bits, remove remaining sepal, put in pot and fry with high heat to coke yellow, slightly spray clear water, cool;
(2) preparation
(1) Radix Pseudostellariae of described weight, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Aconiti Lateralis Preparata, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Bulbus Allii Macrostemonis, Hirudo, Radix Curcumae, Rhizoma Acori Graminei, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Cortex Albiziae, Spica Prunellae, the Radix Paeoniae Alba, Concha Ostreae, Fructus Viticis are decocted with water twice, add for the first time 6 times of amounts of water, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, filter to obtain decoction liquor for the first time;
(2) medicinal residues after filtering are for the first time added to 4 times of amounts of water, intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time;
(3) merge decoction liquor twice, intense fire boils, then uses slow fire boiling 10 minutes, is divided into 2 doses and takes.
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| CN104906265A (en) * | 2015-06-29 | 2015-09-16 | 张保菊 | Traditional Chinese medicine composition for treating coronary heart disease |
| CN104906516A (en) * | 2015-06-29 | 2015-09-16 | 张保菊 | Traditional Chinese medicinal composition for treating coronary heart disease and preparation method of traditional Chinese medicinal composition |
| CN104906277A (en) * | 2015-06-29 | 2015-09-16 | 张保菊 | Traditional Chinese medicine preparation for treating coronary heart disease |
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