CN104491024A - Preparation for complementary treatment of hypertension and preparation method of preparation - Google Patents

Abstract

The invention discloses a preparation for complementary treatment of hypertension. The preparation is prepared from the following crude medicines in parts by weight: 10-20 parts of radix bupleuri, 5-10 parts of ruddle, 9-12 parts of scutellaria baicalensis, 8-16 parts of codonopsis pilosula, 8-15 parts of poria cocos, 7-10 parts of sheep or goat horn, 4-6 parts of raw fossil fragments, 6-10 parts of paniculate swallowwort root, 4-6 parts of raw oyster, 3-6 parts of wine-treated rhubarb, 10-20 parts of lotus leaves, 6-9 parts of indigo naturalis and 4-8 parts of garden balsam. The preparation for complementary treatment of hypertension disclosed by the invention further has the following good benefits: the preparation, which is prepared from the medicinal materials which are capable of promoting blood circulation and removing stasis, promoting circulation of qi and stopping blooding, has the efficacies of reducing blood and lipid and improving microorganism; the formula has a significant curative effect on hypertension, and the formula is high in safety, free from any toxic and side effect, and capable of enhancing the body immunity and relieving the occurrence of hypertension complication.

Description

Complement each other the hypertensive preparation for the treatment of and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to the complement each other hypertensive preparation for the treatment of and preparation method.

Background technology

Hypertension is Important cause of disease and the risk factor of multiple cardiovascular and cerebrovascular disease, can affect the 26S Proteasome Structure and Function of the internal organs such as the heart, brain, kidney.The feature that prevalence is high, disability rate is high, mortality rate is high, awareness is low, control rate is low, treatment rate is low is had in China's hypertension.Therefore, hypertensive prevent quite arduous.

Hypertension can be divided into two classes clinically: 1, essential hypertension: be a kind of with blood pressure rising for main clinical manifestation and the not yet clear and definite independent disease of the cause of disease.2, secondary hypertension: be also called symptomatic hypertension, in this kind of disease, the cause of disease is clear and definite, and hypertension is only one of clinical manifestation of this kind of disease, and blood pressure can temporary or persistency rising.Hypertensive symptom varies with each individual.Early stage possibility is asymptomatic or symptom is not obvious, blood pressure only can occur after fatigue, psychentonia, anxious state of mind and raise, and recover normal after rest.Along with the course of disease extends, blood pressure significantly continues to raise, and there will be various symptom gradually.Now be called as benign hypertension.Benign hypertension common clinical symptoms has headache, dizziness, absent minded, hypomnesis, numb limbs and tense tendons, nocturia increase, cardiopalmus, uncomfortable in chest, weak etc.Even there will be severe headache, vomiting, cardiopalmus, the symptom such as dizzy when blood pressure is elevated to a certain degree suddenly, time serious, obnubilation, tic can occur.This just belongs to accelerated hypertension and hypertension critical illness, how infringement and the pathological changes of the organs such as the serious heart, brain, kidney can occur in a short time, as apoplexy, heart infarction, renal failure etc.Symptom there is no consistent relation with the level that blood pressure raises.

Application publication number CN 103599394 A(application number 201310504570.X) Chinese patent literature disclose one and treat hypertensive Chinese medicine, said composition comprises following component: Cortex Eucommiae 10-30 part, Rhizoma Chuanxiong 20-40 part, Rhizoma Alismatis 20-40 part, Rhizoma Atractylodis 20-40 part, Radix Dipsaci 20-40 part, Fructus Corni 10-30 part, Ramulus Uncariae Cum Uncis 5-15 part, Rhizoma Gastrodiae 5-15 part, Radix Astragali 40-80 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Ophiopogonis 20-40 part, Radix Pseudostellariae 10-20 part.Application publication number CN 103690797 A(application number 201310721045.3) Chinese patent literature disclose a kind of medicine for lowering high blood pressure, be made up of the raw material of Chinese medicine of following parts by weight: Ramulus Uncariae Cum Uncis 20-30, Concha Haliotidis 20-30, Radix Paeoniae Alba 15-20, Radix Puerariae 15-30, Spica Prunellae 15-30, Radix Scutellariae 9-15, Flos Chrysanthemi 10-15, Rhizoma Chuanxiong 10-15, Herba Taxilli 10-15, Rhizoma Gastrodiae 10-15, Poria 5-10, Rhizoma Atractylodis Macrocephalae 5-10, Pheretima 10-20.Application publication number CN 102961466 A(application number 201210487511.1) Chinese patent literature disclose one and treat hypertensive sufficient liquid, be made up of according to parts by weight following component: Spica Prunellae 5-14 part, Caulis Spatholobi 4-6 part, Oletum Trogopterori 1-6 part, Folium Apocyni Veneti 2-9 part, Concha Ostreae 1-5 part, Ramulus Uncariae Cum Uncis 3-8 part, Cortex Eucommiae 2-9 part, Radix Salviae Miltiorrhizae 1.5-5 part, surplus is water.

Although control the non-difficult matter of blood pressure with Western medicine merely, undeniable Chinese medicine has the advantage of self uniqueness in the treatment of hypertension, can not only reduce blood pressure, and improving symptom, improve the quality of living, prevent target organ damage, reduce the aspects such as complication particularly outstanding.

Summary of the invention

For the deficiencies in the prior art, the hypertensive preparation for the treatment of and preparation method thereof that the object of this invention is to provide that one is prepared simply, taking convenience, action effect complement each other significantly.This Chinese medicine preparation determined curative effect and having no side effect.

Technical scheme of the present invention is:

Complement each other the hypertensive preparation for the treatment of, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Bupleuri 10-20; Haematitum 5-10; Radix Scutellariae 9-12; Radix Codonopsis 8-16; Poria 8-15; Cornu Caprae seu Ovis 7-10; Os Draconis 4-6; Radix Cynanchi Paniculati 6-10; Concha Ostreae 4-6; Radix et Rhizoma Rhei (stir-fried with wine) 3-6; Folium Nelumbinis 10-20; Indigo Naturalis 6-9; Semen Impatientis 4-8.

In preferred scheme, Radix Bupleuri 13-17; Haematitum 6-9; Radix Scutellariae 10-11; Radix Codonopsis 10-14; Poria 10-13; Cornu Caprae seu Ovis 8-9; Os Draconis 4.5-5.5; Radix Cynanchi Paniculati 7-9; Concha Ostreae 4.5-5.5; Radix et Rhizoma Rhei (stir-fried with wine) 4-5; Folium Nelumbinis 13-17; Indigo Naturalis 7-8; Semen Impatientis 5-7.

Be more preferably, Radix Bupleuri 15; Haematitum 7.5; Radix Scutellariae 10.5; Radix Codonopsis 12; Poria 11.5; Cornu Caprae seu Ovis 8.5; Os Draconis 5; Radix Cynanchi Paniculati 8; Concha Ostreae 5; Radix et Rhizoma Rhei (stir-fried with wine) 4.5; Folium Nelumbinis 15; Indigo Naturalis 7.5; Semen Impatientis 6.

Complement each other the hypertensive preparation for the treatment of, and the preparation method of described decoction is:

(1) pour in pot by Mel, be heated to boil, pour radix bupleuri tablet into, fry to deep yellow with slow fire, tack-free is degree, takes out, dries in the air cool; Get Radix Scutellariae removing impurity, clean, put in boiling water and boil 10-20 minute (preferably put in boiling water and boil 15 minutes), take out, vexed system, time consistent to inside and outside humidity, take out, shave while hot, drying for standby;

(2) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis are smashed to pieces respectively, be ground into fine powder, for subsequent use; Os Draconis is ground into powder, is placed in container, adds the clear water (preferably adding the clear water of 4 times amount) of 3-5 times amount, and intense fire heats, and turns slow fire boiling 25-35 minute (preferably turning slow fire boiling 30 minutes), filters, obtains filtrate;

(3) Radix Codonopsis, Poria, Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine), Folium Nelumbinis and Indigo Naturalis are placed in medicinal cupping, add clear water and do not have powder, soak 1.5-3.5 hour (preferably soaking 2.5 hours), big fire is boiled, then add Radix Bupleuri and Radix Scutellariae and step (2) gained fine powder that step (1) processed, slow fire boiling twice, decoct respectively 45-65 minute (preferably each decoct 55 minutes respectively) at every turn, filter, collecting decoction;

(4) in above-mentioned decocting liquid, add step (2) gained filtrate, be evaporated to 2/3 of original liquid volume, sterilizing 15-35 minute (preferred sterilizing 25 minutes), cooling, encapsulation, to obtain final product.

Above-mentioned complementing each other treats the preparation method of hypertensive decoction, and preferred scheme is, in step (1), the vexed time processed is 6-12 hour (the preferred vexed time processed is 8-10 hour, and the time vexed processed be more preferably is 9 hours).

Above-mentioned complementing each other treats the preparation method of hypertensive decoction, and preferred scheme is, in step (4), sterilising temp is 95-115 DEG C (preferred sterilising temp is 100-110 DEG C, and the sterilising temp be more preferably is 105 DEG C).

The preparation method of described pill is:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, and decoct 6-8 minute (preferably decocting 7 minutes), pull out in time, filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) radix bupleuri tablet, is placed in frying pan, fries to micro-Jiao, take out, cool, grind into powder with slow fire, for subsequent use; After getting the dilution of refined honey boiled water, mix thoroughly with Radix Codonopsis sheet, vexed, be then placed in hot medicine cookeding pot, with slow fire heating, constantly stir-fry to yellowish-brown, take out time tack-free, cool, grind, for subsequent use;

(3) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use;

(4) Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine) and Folium Nelumbinis are cleaned, be placed in crock, add clear water to soak, then crock is placed in stove fire, intense fire boils, turn slow fire boiling twice, keep clear water not have powder in decoction process, first time decocts 50-90 minute (preferably first time decocts 70 minutes), and second time decocts 35-65 minute (preferably second time decocts 50 minutes), filter, merge twice decocting liquid; Decocting liquid is condensed into relative density 1.05-1.15(60 DEG C), obtain thick paste,

(5) in above-mentioned thick paste, add Indigo Naturalis and step (1)-step (3) gained fine powder, mix homogeneously, the pill of refined honey general one-tenth Semen Glycines size, 85 DEG C of dry sterilizations, subpackage, to obtain final product.

Above-mentioned complementing each other treats the preparation method of hypertensive pill, and preferred scheme is, the middle 70-110 mesh sieve excessively of step (3) (preferred 80-100 mesh sieve excessively, mistake 90 mesh sieve be more preferably).

The preparation method of described tablet is:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, and decoct 6-8 minute (preferably decocting 7 minutes), pull out in time, filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) radix bupleuri tablet, is placed in frying pan, fries to micro-Jiao, take out, cool, grind into powder with slow fire, for subsequent use; After getting the dilution of refined honey boiled water, mix thoroughly with Radix Codonopsis sheet, vexed, be then placed in hot medicine cookeding pot, with slow fire heating, constantly stir-fry to yellowish-brown, take out time tack-free, cool, grind, for subsequent use;

(3) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use; Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine) and Folium Nelumbinis are cleaned, dry 1-2 hour (preferably drying 1.5 hours for 110 DEG C) for 110 DEG C, be ground into fine powder, add Indigo Naturalis and step (1)-step (3) gained fine powder, mix homogeneously, wetting agent made by the ethanol adding 30%, adds corn starch, dextrin and Icing Sugar (mass ratio of medicated powder and corn starch, dextrin and Icing Sugar is 8:2:0.9:0.6) simultaneously, be processed into tablet, obtain final product.

The preparation method of described thick paste agent is:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, and decoct 6-8 minute (preferably decocting 7 minutes), pull out in time, filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use; Poured into by Mel in pot, be heated to boil, pour radix bupleuri tablet into, fry to deep yellow with slow fire, tack-free is degree, takes out, dries in the air cool;

(3) Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine), Radix Codonopsis, Indigo Naturalis and Folium Nelumbinis are placed in crock, add clear water and soak 2-4 hour (preferably add clear water and soak 3 hours), then crock is placed in stove fire, add the Radix Bupleuri after step (2) process, intense fire boils, and turns slow fire boiling twice, clear water is kept not have powder in decoction process, each decoction respectively 35-75 minute (preferably each decoction respectively 55 minutes), filters, merges twice decocting liquid;

(4) together join in above-mentioned decocting liquid by step (1)-step (2) gained fine powder, pressurization is condensed into paste, 100 DEG C of dry heat sterilization 1-3 hour (preferably 100 DEG C dry heat sterilization 2 hours), and cooling, encapsulation, obtains thick paste agent.

Scientific formula of the present invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:

1,the present invention has selected can strengthen blood circulation promoting and blood stasis dispelling, the medical material of circulation of qi promoting hemostasis, has hypertension and hyperlipemia and improves microcirculatory drug effect;

2,this prescription has significant curative effect to hypertension, and safety is high, without any side effects, has enhancing human body immunity ability, alleviates the generation of hypertension complication;

3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Radix Bupleuri: base is former: this product is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor: bitter, cool.Gui Jing: return liver, gallbladder meridian.Effect: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.

Haematitum: base is former: be the Ore of oxide-based mineral bloodstone.Chemical analysis: main containing iron sesquioxide, wherein ferrum 70%, oxygen 30%, sometimes impure titanium, magnesium, aluminum, silicon and moisture.Nature and flavor: bitter, sweet, flat.Gui Jing: return liver, stomach, heart born of the same parents warp.Function cures mainly: suppressing the hyperactive liver town is inverse, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spit blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.

Radix Scutellariae: base is former: this product is the dry root of labiate Radix Scutellariae.Character: this product conically.Surface brown color or buff, have sparse excipuliform radicula trace. and top is more coarse, and have the vertical wrinkle of distortion or irregular reticulate pattern, rift grain and scabriculous are arranged at bottom.Nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, rushes down people's removing toxic substances, hemostasis, antiabortive.Cure mainly: for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Codonopsis: base is former: the dry root that this product is Campanulaceae Radix Codonopsis, element spends Radix Codonopsis or radix codonpsis tangshen.Chemical analysis: Radix Codonopsis root is containing Saponin, Alkaloid, sucrose, glucose, inulin, starch, mucus and resin etc.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Cure mainly: for deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Poria: base is former: this product is the dry sclerotia of On Polyporaceae Poria.Character: Poria spherical, oval in class, an oblate or irregular agglomerate, not of uniform size.Crust is thin and coarse, and sepia, to pitchy, has obvious shrinkage texture.Nature and flavor: sweet, light are flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Cure mainly: for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Os Draconis: base is former: for ancient times mammal as if the fossil of skeleton of class, rhinoceros class, Hippocampal cortex etc.Chemical analysis: be mainly calcium carbonate, calcium phosphate, still iron content, potassium, sodium, chlorine, sulfate radical etc.Nature and flavor: sweet puckery are flat.Gui Jing: enter the heart, liver, kidney, large intestine channel.Function cures mainly: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.Os Draconis: outwash earth, smashes.

Radix Cynanchi Paniculati: base is former: be root and rhizome or the whole herb with root of asclepiadaceae plant Radix Cynanchi Paniculati.Chemical analysis: herb is containing paeonol about 1%.Finding out again to sarcostin, going acyl Corii Bovis seu Bubali to moor glycoside unit, the first material very similar with removing acyl periplogenin of fine hair milk rattan glycoside and acetic acid, cinnamic acid etc.Root is containing flavonoid glycoside, saccharide, aminoacid, paeonol.Pharmacological action: mouse peritoneal injection Radix Cynanchi Paniculati extracting solution, can show minimizing spontaneous activity, but not extend the length of one's sleep of barbiturates, also have analgesic activity.Nature and flavor: pungent, temperature.Function cures mainly: analgesia, cough-relieving, inducing diuresis to remove edema, promoting blood circulation and detoxication.Treat for stomachache, toothache, rheumatalgia, abdominal pain in menstruation, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria, venom.

Concha Ostreae: base is former: be the shell of Ostreidae animal Crassostrea rivularis, long Concha Ostreae or Dalian Bay Concha Ostreae etc.Chemical analysis: the calcium carbonate containing 80 ~ 95%, calcium phosphate and calcium sulfate, and containing magnesium, aluminum, silicon and ferrum oxide etc.Nature and flavor: salty wet, cool.Gui Jing: enter liver, kidney channel.Function cures mainly: yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, and arresting seminal emission reduces phlegm, softening the hard mass.Control infantile convulsion, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Concha Ostreae: clean, dry, pulverize use.

Cornu Caprae seu Ovis: base is former: be the angle of bovid male goat or male sheep.Pharmacological action: antitumor action.Nature and flavor: salty are cool.Gui Jing: enter liver, heart channel.Function cures mainly: heat clearing away, relieving convulsion, improving eyesight, removing toxic substances.Control pediatric epilepsy scared, headache due to pathogenic wind-heat, unhappy, spit blood, optic atrohic blindness, toxic swelling.

Radix Et Rhizoma Rhei: base is former: be the rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Nature and flavor: bitter, cold.Gui Jing: enter stomach, large intestine, Liver Channel.Function cures mainly: purge heat poison, and removing mass is stagnant, clots absorbing blood.Control excess-heat constipation, delirium sends out holder, food stagnation feeling of fullness, and dysentery is from the beginning of, tenesmus, and stasis of blood menolipsis is closed, lump in the abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spit blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, also urinates, carbuncle and ulcer toxic swelling, furuncle, burn.Radix et Rhizoma Rhei (stir-fried with wine): get rhubarb tablets yellow wine and evenly spray, micro-stewing, put the micro-stir-fry of the interior slow fire of pot, take out and dry (rhubarb tablets 100 jin yellow wine 14 jin).

Folium Nelumbinis: base is former: this product is the dried leaves of nymphaeaceae plant lotus.Chemical analysis: leaf is containing nuciferine, nuciferine, miltanthin, armepavine, pronuciferine (+)-Pronuciferine, N-demethyl nuciferine, D-N-methyl coclaurine, anonaine, liriodendrin, Quercetin, Isoquercitrin, lotus glycoside, tartaric acid, citric acid, malic acid, gluconic acid, oxalic acid, succinic acid, tannin.Also containing the alkaline components of resisting mitosis effect.Nature and flavor: bitter are flat.Gui Jing: return liver, spleen, stomach warp.Effect: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.Cure mainly: for multiple hemorrhage and puerperal blood faints.

Indigo Naturalis: base is former: this product is acanthaceous vegetable acanthaceous indigo, the leaf of polygonaceae plant polygonum tinctorium ait. or cruciferae isatis or stem and leaf be through processing obtained dried powder or agglomerate.Character: this product is navy blue powder, body is light, easily flies upward; Or in irregular porous agglomerate, with hand rubbing twist with the fingers smalls.Nature and flavor: salty, cold.Gui Jing: return Liver Channel.Effect: heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.Cure mainly: for maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.

Semen Impatientis: base is former: be the seed of Balsaminaceae plant Impatientis.Chemical analysis: containing balsaminasterol, Parinaric Acid, Saponin, fatty oil, polysaccharide, protein, aminoacid, volatile oil, and the flavonoid such as the polysaccharid glucoside of Quercetin and the derivant of nimbecetin.Pharmacological action: 1. to the effect in uterus: the tincture of SEMEN IMPATIENTIS, decoct and water logging agent have obvious excitation to unpregnancy rabbit isolated uterine and unpregnancy, pregnant each phase guinea pig in vitro uterus, show as rhythm and pace of moving things contraction to speed, tensity increases even tetanic contraction.2. contraceptive efficacy.Nature and flavor: toil, temperature, poisonous.Gui Jing: 1. " beautiful Chinese catalpa medicine solution ": " enter kidney meridian." 2. " book on Chinese herbal medicine is new again ": " enter liver, lung two warp." function cures mainly: removing blood stasis, removing food stagnancy, softening the hard mass.Control amenorrhea, long-pending block, dysphagic, outer infections heavily fortified point is swollen, a fishbone or other bone caught in the throat not under.

embodiment 1complement each other the hypertensive preparation for the treatment of, it is characterized in that, be prepared from by following bulk drugs, be weight portion (400g/ part): Radix Bupleuri 10 parts; Haematitum 5 parts; Radix Scutellariae 9 parts; Radix Codonopsis 8 parts; 8 parts, Poria; Cornu Caprae seu Ovis 7 parts; Os Draconis 4 parts; Radix Cynanchi Paniculati 6 parts; Concha Ostreae 4 parts; Radix et Rhizoma Rhei (stir-fried with wine) 3 parts; 10 parts, Folium Nelumbinis; Indigo Naturalis 6 parts; Semen Impatientis 4 parts.

The above-mentioned preparation method for the treatment of hypertensive decoction that complements each other is:

(1) pour in pot by Mel, be heated to boil, pour radix bupleuri tablet into, fry to deep yellow with slow fire, tack-free is degree, takes out, dries in the air cool; Get Radix Scutellariae removing impurity, clean, put in boiling water and boil 20 minutes, take out, vexed system, time consistent to inside and outside humidity, take out, shave while hot, drying for standby;

(2) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis are smashed to pieces respectively, be ground into fine powder, for subsequent use; Os Draconis is ground into powder, is placed in container, adds the clear water of 5 times amount, and intense fire heats, and turns slow fire boiling 35 minutes, filters, obtains filtrate;

(3) Radix Codonopsis, Poria, Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine), Folium Nelumbinis and Indigo Naturalis are placed in medicinal cupping, add clear water and do not have powder, soak 3.5 hours, big fire is boiled, then add Radix Bupleuri and Radix Scutellariae and step (2) gained fine powder that step (1) processed, slow fire boiling twice, decocts 65 minutes at every turn respectively, filter, collecting decoction;

(4) in above-mentioned decocting liquid, add step (2) gained filtrate, be evaporated to 2/3 of original liquid volume, sterilizing 35 minutes, cooling, encapsulation, to obtain final product.

The instructions of taking of decoction of the present invention is: every day 2 times, each 150-180mL, 20 days courses for the treatment of.

Model case: square XX, female, 65 years old.In December, 2011 comes here and goes to a doctor.Patient's readme: before half a year without obvious inducement start giddy, weak, accompany drowsiness, staring spells, once repeatedly in treatments such as outpatient service row expander, blood circulation promoting and blood stasis dispelling, symptom was slightly alleviated.In October, 2011, conditions of patients obviously increased the weight of, blurred vision.Medical history: have hypertension history to have a surplus for 6 years, be up to 230/126mmHg, at ordinary times Administration of Valsartan capsule, Nifedipine sustained release tablets, fluctuation of blood pressure is in 160-173/100-110 mmHg.Check: patient's edema of pair of lower extremities, food is fuzzy, for hypertension leads to complications.

Take the present embodiment gained complement each other treatment hypertensive decoction, instructions of taking: every day 2 times, each 150-180mL, 20 days courses for the treatment of.After two courses for the treatment of of medication, patients' blood reduces to 140/95 mmHg, and other malaise symptoms obtain to be alleviated to a certain extent, and continue two courses for the treatment of of medication, patients' blood is normal, picks body, after drug withdrawal three months, and blood pressure stabilization, without bounce-back.

embodiment 2complement each other the hypertensive preparation for the treatment of, it is characterized in that, be prepared from by following bulk drugs, be weight portion (200g/ part): Radix Bupleuri 20 parts; Haematitum 10 parts; Radix Scutellariae 12 parts; Radix Codonopsis 16 parts; 15 parts, Poria; Cornu Caprae seu Ovis 10 parts; Os Draconis 6 parts; Radix Cynanchi Paniculati 10 parts; Concha Ostreae 6 parts; Radix et Rhizoma Rhei (stir-fried with wine) 6 parts; 20 parts, Folium Nelumbinis; Indigo Naturalis 9 parts; Semen Impatientis 8 parts.

The above-mentioned preparation method for the treatment of hypertensive pill that complements each other is:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, decocts 7 minutes, pulls out in time, and filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) radix bupleuri tablet, is placed in frying pan, fries to micro-Jiao, take out, cool, grind into powder with slow fire, for subsequent use; After getting the dilution of refined honey boiled water, mix thoroughly with Radix Codonopsis sheet, vexed, be then placed in hot medicine cookeding pot, with slow fire heating, constantly stir-fry to yellowish-brown, take out time tack-free, cool, grind, for subsequent use;

(3) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, cross 90 mesh sieves, for subsequent use;

(4) Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine) and Folium Nelumbinis are cleaned, and are placed in crock, add clear water and soak, then crock is placed in stove fire, intense fire boils, and turns slow fire boiling twice, keeps clear water not have powder in decoction process, and first time decocts 70 minutes, second time decocts 50 minutes, filters, merges twice decocting liquid; Decocting liquid is condensed into relative density 1.05-1.15(60 DEG C), obtain thick paste,

(5) in above-mentioned thick paste, add Indigo Naturalis and step (1)-step (3) gained fine powder, mix homogeneously, the pill of refined honey general one-tenth Semen Glycines size, 85 DEG C of dry sterilizations, subpackage, to obtain final product.

The instructions of taking of pill of the present invention is: every day three times, each 4-6 ball, 20 days courses for the treatment of.

Model case: king XX, man, 62 years old, retired professor.Patient's readme: hypertension is had a surplus for 3 years, and take depressor at ordinary times, after medication, blood pressure declines to some extent, rebounds after drug withdrawal, carrys out my institute's treatment in June, 2011 upon somebody's introduction.Check: blood pressure values is 178/110 mmHg, without dizzy malaise symptoms, without other complication.

Take the present embodiment gained complement each other treatment hypertensive pill, instructions of taking is: every day three times, each 4-6 ball, 20 days courses for the treatment of.After two courses for the treatment of of medication, blood pressure values becomes 122/82 mmHg, pays a return visit after drug withdrawal in 3 months, and pressure value does not find to raise, bounce-back.

embodiment 3complement each other the hypertensive preparation for the treatment of, it is characterized in that, be prepared from by following bulk drugs, be weight portion (350g/ part): Radix Bupleuri 13 parts; Haematitum 6 parts; Radix Scutellariae 10 parts; Radix Codonopsis 10 parts; 10 parts, Poria; Cornu Caprae seu Ovis 8 parts; Os Draconis 4.5 parts; Radix Cynanchi Paniculati 7 parts; Concha Ostreae 4.5 parts; Radix et Rhizoma Rhei (stir-fried with wine) 4 parts; 13 parts, Folium Nelumbinis; Indigo Naturalis 7 parts; Semen Impatientis 5 parts.

The above-mentioned preparation method for the treatment of hypertensive tablet that complements each other is:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, decocts 7 minutes, pulls out in time, and filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) radix bupleuri tablet, is placed in frying pan, fries to micro-Jiao, take out, cool, grind into powder with slow fire, for subsequent use; After getting the dilution of refined honey boiled water, mix thoroughly with Radix Codonopsis sheet, vexed, be then placed in hot medicine cookeding pot, with slow fire heating, constantly stir-fry to yellowish-brown, take out time tack-free, cool, grind, for subsequent use;

(3) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use; Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine) and Folium Nelumbinis are cleaned, dry 1.5 hours for 110 DEG C, be ground into fine powder, add Indigo Naturalis and step (1)-step (3) gained fine powder, mix homogeneously, wetting agent made by the ethanol adding 30%, adds corn starch, dextrin and Icing Sugar (mass ratio of medicated powder and corn starch, dextrin and Icing Sugar is 8:2:0.9:0.6) simultaneously, be processed into tablet, obtain final product.

The instructions of taking of Tablets is: every day 3 times, each 4-6 sheet, 20 days courses for the treatment of.

Model case: Lee XX, female, 64 years old, people from Tianjin.Patient's readme: the hypertension history having the more than ten years, ate a lot of depressor, what have does not have positive effect, and some medicines are eaten up rear blood pressure and fallen too low, and causes obstinate headache and uncomfortable, once drug withdrawal, blood pressure bounce-back very serious.Morning and evening blood pressure easily raise, noon is slightly low, often can't fall asleep evening at ordinary times, has slept also bad dream repeatedly.My institute's treatment is carried out through friend recommendation.Inspection patients' blood is 173/100mmHg, is hypertension 2 grades.

Take the present embodiment gained complement each other treatment hypertensive tablet, after taking a course for the treatment of, condition of illness obtains obvious improvement, and blood pressure also obtains certain alleviation, then continues to take two courses for the treatment of, and originally concurrent multiple symptom fades away, and blood pressure is normal.After drug withdrawal 3 months, blood pressure stabilization was without bounce-back.

embodiment 4complement each other the hypertensive preparation for the treatment of, it is characterized in that, be prepared from by following bulk drugs, be weight portion (250g/ part): Radix Bupleuri 17 parts; Haematitum 9 parts; Radix Scutellariae 11 parts; Radix Codonopsis 14 parts; 13 parts, Poria; Cornu Caprae seu Ovis 9 parts; Os Draconis 5.5 parts; Radix Cynanchi Paniculati 9 parts; Concha Ostreae 5.5 parts; Radix et Rhizoma Rhei (stir-fried with wine) 5 parts; 17 parts, Folium Nelumbinis; Indigo Naturalis 8 parts; Semen Impatientis 7 parts.

The above-mentioned preparation method for the treatment of hypertensive thick paste agent that complements each other is:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, decocts 7 minutes, pulls out in time, and filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use; Poured into by Mel in pot, be heated to boil, pour radix bupleuri tablet into, fry to deep yellow with slow fire, tack-free is degree, takes out, dries in the air cool;

(3) Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine), Radix Codonopsis, Indigo Naturalis and Folium Nelumbinis are placed in crock, add clear water and soak 3 hours, then crock is placed in stove fire, add the Radix Bupleuri after step (2) process, intense fire boils, and turns slow fire boiling twice, clear water is kept not have powder in decoction process, each decoction respectively 55 minutes, filters, merges twice decocting liquid;

(4) together join in above-mentioned decocting liquid by step (1)-step (2) gained fine powder, pressurization is condensed into paste, 100 DEG C of dry heat sterilizations 2 hours, cooling, and encapsulation, obtains thick paste agent.

The instructions of taking of thick paste agent of the present invention is: twice daily, each 3-5 spoon, warm boiled water, 20 days courses for the treatment of.

Model case: Liu XX, man, 63 years old, retired cadre, people from Hebei.Patient's readme: in October, 2010, accidentally sees healthy talk show when seeing TV, introduces hypertension to the harm of middle-aged and elderly people and control.Rise for the moment, have purchased electric sphygmomanometer in local pharmacy and measure.The pressure value recorded morning is 130/86mmHg, and recording pressure value noon is 143/92 mmHg, and recording blood pressure afternoon is 150/84 mmHg.Mr. Liu household introduces, and Mr. Liu is irritability at ordinary times, and irascible, diet is partially salty, drinks well.

Take the present embodiment gained complement each other treatment hypertensive thick paste agent, after taking a course for the treatment of, blood pressure obtains certain alleviation, then continues to take two courses for the treatment of, and blood pressure is normal.After drug withdrawal 3 months, blood pressure stabilization was without bounce-back.Exhort that patient is careful in one's diet, keep good phychology.

embodiment 5complement each other the hypertensive preparation for the treatment of, it is characterized in that, be prepared from by following bulk drugs, be weight portion (300g/ part): Radix Bupleuri 15 parts; Haematitum 7.5 parts; Radix Scutellariae 10.5 parts; Radix Codonopsis 12 parts; 11.5 parts, Poria; Cornu Caprae seu Ovis 8.5 parts; Os Draconis 5 parts; Radix Cynanchi Paniculati 8 parts; Concha Ostreae 5 parts; Radix et Rhizoma Rhei (stir-fried with wine) 4.5 parts; 15 parts, Folium Nelumbinis; Indigo Naturalis 7.5 parts; Semen Impatientis 6 parts.

The above-mentioned preparation method for the treatment of hypertensive decoction that complements each other is:

(1) pour in pot by Mel, be heated to boil, pour radix bupleuri tablet into, fry to deep yellow with slow fire, tack-free is degree, takes out, dries in the air cool; Get Radix Scutellariae removing impurity, clean, put in boiling water and boil 15 minutes, take out, vexed system 9 hours, time consistent to inside and outside humidity, take out, shave while hot, drying for standby;

(2) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis are smashed to pieces respectively, be ground into fine powder, for subsequent use; Os Draconis is ground into powder, is placed in container, adds the clear water of 4 times amount, and intense fire heats, and turns slow fire boiling 30 minutes, filters, obtains filtrate;

(3) Radix Codonopsis, Poria, Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine), Folium Nelumbinis and Indigo Naturalis are placed in medicinal cupping, add clear water and do not have powder, soak 2.5 hours, big fire is boiled, then add Radix Bupleuri and Radix Scutellariae and step (2) gained fine powder that step (1) processed, slow fire boiling twice, decocts 55 minutes at every turn respectively, filter, collecting decoction;

(4) in above-mentioned decocting liquid, add step (2) gained filtrate, be evaporated to 2/3 of original liquid volume, 105 DEG C of sterilizings 25 minutes, cooling, encapsulation, to obtain final product.

The instructions of taking of decoction of the present invention is: every day 2 times, each 150-180mL, 20 days courses for the treatment of.

test example 1a kind of clinical practice for the treatment of hypertensive Chinese medicine decoction of embodiment 5 gained:

1, data and method

1.1 physical data

In JIUYUE, 2010 in December ,-2013, chooses 316 examples in 4 hospitals and is diagnosed as hyperpietic.Wherein male patient 135 example, female patient 181 example; Oldest 70 years old, minimum 33 years old of age.In all patients, 1 grade of hyperpietic 87 example, accounts for 27.5%, and 2 grades of hyperpietic 80 examples, account for 25.3%, and 3 grades of hyperpietic 73 examples, account for 23.1%, and isolated systolic hypertension patients 76 example, accounts for 24.1%.

1.2 diagnostic criteria

The standard of diagnosis employing Chinese Treatment Guidelines for Hypertension suggestion in 2000, as shown in table 1:

1.3 Therapeutic Method

All patients are divided into two groups at random, experimental group and matched group, and experimental group takes embodiment 5 products obtained therefrom, and instructions of taking is: every day 2 times, each 150-180mL, 20 days courses for the treatment of.Matched group takes other medicine (as conventional medication such as Duzhong Jiangya Tablets, FUFANG LIXUEPING PIAN, amlodipine besylate tablets).Observe three courses for the treatment of of treatment altogether.

1.4 efficacy assessment standard

Cure: 1-3 level hyperpietic and isolated systolic hypertension patients after treatment, systolic pressure and diastolic pressure are all in normal range, maintain two months without bounce-back;

Effective: to treat rear 2 grades and 3 grades of hyperpietics and drop to 1 grade, maintain two months without bounce-back;

Take a turn for the better: 3 grades of hyperpietics drop to 2 grades, maintain two months without bounce-back;

Invalid: the rear pressure value for the treatment of is unchanged or increase the weight of.

Total effective rate=(cure number of cases+effective number of cases+improvement number of cases) ∕ total inspection case load × 100%.

1.5 therapeutic outcome

Therapeutic outcome is as shown in table 2:

Table 2: take embodiment 5 product 33-70 year patient treatment outcome

Therapeutic effect: cure 129 examples (71.7%), effective 36 examples (20%), 14 examples that take a turn for the better (7.7%); Invalid 1 example (0.6%), total effective rate 99.4%.Successful is better than matched group.

The present invention selects Radix Bupleuri, Haematitum, Radix Scutellariae, Radix Codonopsis, Poria, Cornu Caprae seu Ovis, Os Draconis, Radix Cynanchi Paniculati, Concha Ostreae, Radix et Rhizoma Rhei (stir-fried with wine), Folium Nelumbinis, Indigo Naturalis and Semen Impatientis to carry out compatibility, produce synergism after making these drug regimens, more effectively can treat hypertension.Fang Zhong, Radix Bupleuri has reconciling superficies and interior, soothing the liver, effect of yang invigorating; Haematitum suppressing the hyperactive liver town is inverse, cooling blood for hemostasis; Folium Nelumbinis clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis; Indigo Naturalis heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion; Radix Scutellariae heat clearing and damp drying, rushes down people's removing toxic substances; Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; Radix Cynanchi Paniculati has inducing diuresis to remove edema, effect of promoting blood circulation and detoxication; Cornu Caprae seu Ovis heat clearing away, relieving convulsion, improving eyesight, removing toxic substances; Full side's compatibility, plays the merit of inducing diuresis to remove edema, spleen invigorating lung benefiting altogether.Treat three courses for the treatment of, effective percentage can reach 99.4%.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. complement each other the hypertensive preparation for the treatment of, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Bupleuri 10-20; Haematitum 5-10; Radix Scutellariae 9-12; Radix Codonopsis 8-16; Poria 8-15; Cornu Caprae seu Ovis 7-10; Os Draconis 4-6; Radix Cynanchi Paniculati 6-10; Concha Ostreae 4-6; Radix et Rhizoma Rhei (stir-fried with wine) 3-6; Folium Nelumbinis 10-20; Indigo Naturalis 6-9; Semen Impatientis 4-8.

2. complement each other treatment hypertensive preparation as claimed in claim 1, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Bupleuri 13-17; Haematitum 6-9; Radix Scutellariae 10-11; Radix Codonopsis 10-14; Poria 10-13; Cornu Caprae seu Ovis 8-9; Os Draconis 4.5-5.5; Radix Cynanchi Paniculati 7-9; Concha Ostreae 4.5-5.5; Radix et Rhizoma Rhei (stir-fried with wine) 4-5; Folium Nelumbinis 13-17; Indigo Naturalis 7-8; Semen Impatientis 5-7.

3. complement each other treatment hypertensive preparation as claimed in claim 1, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Bupleuri 15; Haematitum 7.5; Radix Scutellariae 10.5; Radix Codonopsis 12; Poria 11.5; Cornu Caprae seu Ovis 8.5; Os Draconis 5; Radix Cynanchi Paniculati 8; Concha Ostreae 5; Radix et Rhizoma Rhei (stir-fried with wine) 4.5; Folium Nelumbinis 15; Indigo Naturalis 7.5; Semen Impatientis 6.

4. the hypertensive preparation for the treatment of that complements each other as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:

(1) pour in pot by Mel, be heated to boil, pour radix bupleuri tablet into, fry to deep yellow with slow fire, tack-free is degree, takes out, dries in the air cool; Get Radix Scutellariae removing impurity, clean, put in boiling water and boil 10-20 minute (preferably put in boiling water and boil 15 minutes), take out, vexed system, time consistent to inside and outside humidity, take out, shave while hot, drying for standby;

(2) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis are smashed to pieces respectively, be ground into fine powder, for subsequent use; Os Draconis is ground into powder, is placed in container, adds the clear water (preferably adding the clear water of 4 times amount) of 3-5 times amount, and intense fire heats, and turns slow fire boiling 25-35 minute (preferably turning slow fire boiling 30 minutes), filters, obtains filtrate;

(3) Radix Codonopsis, Poria, Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine), Folium Nelumbinis and Indigo Naturalis are placed in medicinal cupping, add clear water and do not have powder, soak 1.5-3.5 hour (preferably soaking 2.5 hours), big fire is boiled, then add Radix Bupleuri and Radix Scutellariae and step (2) gained fine powder that step (1) processed, slow fire boiling twice, decoct respectively 45-65 minute (preferably each decoct 55 minutes respectively) at every turn, filter, collecting decoction;

(4) in above-mentioned decocting liquid, add step (2) gained filtrate, be evaporated to 2/3 of original liquid volume, sterilizing 15-35 minute (preferred sterilizing 25 minutes), cooling, encapsulation, to obtain final product.

5. as claimed in claim 4 decoction preparation method, it is characterized in that, in step (1), the vexed time processed is 6-12 hour (the preferred vexed time processed is 8-10 hour, and the time vexed processed be more preferably is 9 hours).

6. as claimed in claim 4 decoction preparation method, it is characterized in that, sterilising temp is 95-115 DEG C (preferred sterilising temp is 100-110 DEG C, and the sterilising temp be more preferably is 105 DEG C) in step (4).

7. the hypertensive preparation for the treatment of that complements each other as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, and decoct 6-8 minute (preferably decocting 7 minutes), pull out in time, filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) radix bupleuri tablet, is placed in frying pan, fries to micro-Jiao, take out, cool, grind into powder with slow fire, for subsequent use; After getting the dilution of refined honey boiled water, mix thoroughly with Radix Codonopsis sheet, vexed, be then placed in hot medicine cookeding pot, with slow fire heating, constantly stir-fry to yellowish-brown, take out time tack-free, cool, grind, for subsequent use;

(3) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use;

(4) Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine) and Folium Nelumbinis are cleaned, be placed in crock, add clear water to soak, then crock is placed in stove fire, intense fire boils, turn slow fire boiling twice, keep clear water not have powder in decoction process, first time decocts 50-90 minute (preferably first time decocts 70 minutes), and second time decocts 35-65 minute (preferably second time decocts 50 minutes), filter, merge twice decocting liquid; Decocting liquid is condensed into relative density 1.05-1.15(60 DEG C), obtain thick paste,

(5) in above-mentioned thick paste, add Indigo Naturalis and step (1)-step (3) gained fine powder, mix homogeneously, the pill of refined honey general one-tenth Semen Glycines size, 85 DEG C of dry sterilizations, subpackage, to obtain final product.

8. as claimed in claim 4 pill preparation method, it is characterized in that, cross 70-110 mesh sieve (preferred cross 80-100 mesh sieve, mistake 90 mesh sieve be more preferably) in step (3).

9. the hypertensive preparation for the treatment of that complements each other as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, and decoct 6-8 minute (preferably decocting 7 minutes), pull out in time, filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) radix bupleuri tablet, is placed in frying pan, fries to micro-Jiao, take out, cool, grind into powder with slow fire, for subsequent use; After getting the dilution of refined honey boiled water, mix thoroughly with Radix Codonopsis sheet, vexed, be then placed in hot medicine cookeding pot, with slow fire heating, constantly stir-fry to yellowish-brown, take out time tack-free, cool, grind, for subsequent use;

(3) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use; Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine) and Folium Nelumbinis are cleaned, dry 1-2 hour (preferably drying 1.5 hours for 110 DEG C) for 110 DEG C, be ground into fine powder, add Indigo Naturalis and step (1)-step (3) gained fine powder, mix homogeneously, wetting agent made by the ethanol adding 30%, adds corn starch, dextrin and Icing Sugar (mass ratio of medicated powder and corn starch, dextrin and Icing Sugar is 8:2:0.9:0.6) simultaneously, be processed into tablet, obtain final product.

10. the hypertensive preparation for the treatment of that complements each other as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is as follows:

(1) in copper or aluminum pot, first thumbnail is spread one deck, then Poria is cut into small pieces, above being placed on, then spreading one deck with thumbnail, cover, place it in stewing out of water in cauldron saturating, take out, let cool, peel off bean curd, be ground into fine powder; Pericarpium Zanthoxyli is put in cloth bag and is added decocting soup, removes slag, adds Radix Scutellariae, and decoct 6-8 minute (preferably decocting 7 minutes), pull out in time, filter water purification, puts into yellow wine basin and mix thoroughly, puts in food steamer and steams thoroughly, take out, dry, be ground into fine powder;

(2) Haematitum, Concha Ostreae, Semen Impatientis, Cornu Caprae seu Ovis and Os Draconis are placed in Chinese medicine grinder to pulverize, sieve for subsequent use; Poured into by Mel in pot, be heated to boil, pour radix bupleuri tablet into, fry to deep yellow with slow fire, tack-free is degree, takes out, dries in the air cool;

(3) Radix Cynanchi Paniculati, Radix et Rhizoma Rhei (stir-fried with wine), Radix Codonopsis, Indigo Naturalis and Folium Nelumbinis are placed in crock, add clear water and soak 2-4 hour (preferably add clear water and soak 3 hours), then crock is placed in stove fire, add the Radix Bupleuri after step (2) process, intense fire boils, and turns slow fire boiling twice, clear water is kept not have powder in decoction process, each decoction respectively 35-75 minute (preferably each decoction respectively 55 minutes), filters, merges twice decocting liquid;

(4) together join in above-mentioned decocting liquid by step (1)-step (2) gained fine powder, pressurization is condensed into paste, 100 DEG C of dry heat sterilization 1-3 hour (preferably 100 DEG C dry heat sterilization 2 hours), and cooling, encapsulation, obtains thick paste agent.