CN104873693A - Traditional Chinese medicine preparation for relieving cough as well as preparation method and application of traditional Chinese medicine preparation - Google Patents

Abstract

The invention relates to a traditional Chinese medicine preparation for relieving a cough as well as a preparation method and application of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation for relieving the cough is prepared from the following raw materials: folia perillae acutae, platycodon grandiflorum, ephedra, radix peucedani, semen armeniacae amarae, liquorice, pericarpium citri reticulatae, pinellia ternate, poria cocos, fructus aurantii and radix scutellariae; and the preparation method comprises the following steps: mixing the raw materials, namely folia perillae acutae, platycodon grandiflorum, ephedra, radix peucedani, semen armeniacae amarae, liquorice, fructus forsythia, coptis chinensis, rheum officinale and rhizoma atractylodis; adding a hydrochloric acid solution, soaking and stewing to obtain a residue I and a filtrate I; soaking the filter residue I into a sodium hydroxide solution, stewing, and filtering to obtain a filtrate II; crushing other components of the raw materials, infiltrating into an ethanol solution, and decocting to obtain a residue III; mixing the residue III with water, and decocting to obtain filtrate III; and mixing the filtrate I, the filtrate II and the filtrate III, filtering, and adjusting the pH value to be 5-7, so as to obtain the traditional Chinese medicine preparation for relieving the cough. The traditional Chinese medicine preparation is used for relieving the cough and gout, is significant in curative effect and high in utilization efficiency.

Description

A kind of Chinese medicine preparation for antitussive, preparation method and application

Technical field

The invention belongs to a kind of field of Chinese herbal medicine technology, specifically relate to a kind of Chinese medicine preparation for antitussive, preparation method and application.

Background technology

Along with the development of society, the living standard of people is more and more higher, and household, friend meet and society's dinner party increases gradually, smoke, drink and increase, add that people more and more focus on fashion, take notice of demeanour, be reluctant when it cyclostrophic is cold to add clothing in time, cause cough incidence more and more higher.

The outside of cough is characterized by, and when the mucosa of throat or trachea is upset, rapid air-breathing, exhales immediately consumingly, the mucosa irriate of vocal cord vibration sounding throat or trachea and suddenly air is expelled out in lung and with the noise of explosion.

Theory of Chinese medical science is thought, cough is because of diseases caused by exogenous pathogenic factor six climate exopathogens, internal organs internal injury, affects the sound disease having expectorant caused by the lung.See " Plain Questions the five internal organs generate a section "." Plain Questions pathogenesis gas should save one's life collection ": " cough meaning sound without expectorant, lung qi is hindered and also unclear; It is noiseless and have expectorant for coughing, spleen wet dynamic and be expectorant also.Cough meaning has expectorant and sound, and lid moves in lung qi due to wound and wets in spleen, cough and for coughing also ".Because exopathogen violates lung, or internal organs internal injury, involves caused by the lung.

Doctor trained in Western medicine theory is thought, cough (Cough) is a kind of protectiveness respiratory reflex action of human body.Effectively can remove the secretions in respiratory tract by coughre flex or enter the foreign body of air flue.But cough also has disadvantageous one side, violent cough can cause respiratory tract hemorrhage, and as a long time, frequently, violent cough affects work, has a rest, even causes laryngalgia, and hoarseness and breathing myalgia, then belong to pathological phenomenon.

The action of cough: from the stimulation of organ beyond respiratory system and respiratory system (as brain, ear, internal organs) through vagus nerve, the Sensory nerve fibre of nervus glossopharyngeus and nervi trigeminus and skin imports into.Through nervus laryngeus inferior, phrenic nerves and spinal nerves pass to pharynx flesh respectively, glottis, and diaphragm and other respiratory muscles, cause cough action.First cough action is quick very brief air-breathing, and diaphragm declines, and glottis is closed rapidly, and respiratory muscle and abdominal muscle rapid desufflation, make intrapulmonic pressure rise rapidly immediately; Then glottis throws open, lung inner high voltage jet-impingement and going out, and impact glottis crack and cough action and the special sound occur, respiratory tract endocrine or foreign body etc. are also discharged thereupon.

Cough main manifestations be nasal obstruction, watery nasal discharge, excessive phlegm, often with chest pain, lose weight, dyspnea, the symptom such as dizziness is nose heave, wheezing sound, throat are itched, can not get the cough that healing can cause variability for a long time.

The internal therapy cough of current state is main based on chemicals, and be aided with some Chinese Patent Medicines, but therapeutic effect is not obvious, treatment cycle is long.For rapid cough-relieving, improve patients ' life quality, improve work quality, the medicine urgently develop determined curative effect, having no adverse reaction.

At present, the Chinese medicine preparation that treatment cough adopts has little Green Dragon mixture, GUILONG KECHUANNING JIAONANG, Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae, tendril-leaved fritillary bulb cough-relieving dew, MILIAN CHUANBEI PIPA GAO, intensified loquet distillate, nourishing YIN and clearing away lung-heat cream, lung clearing and phlegm eliminating pill, Mengshi Guntan Wan etc.

The main component of little Green Dragon mixture is Herba Ephedrae, osmanthus, the Radix Paeoniae Alba, Rhizoma Zingiberis, Herba Asari, Radix Glycyrrhizae (processed with honey), Rhizoma Pinelliae Preparatum, Fructus Schisandrae Chinensis.Function is induced sweat dissipating fluid-retention, relieving cough and asthma.For the fever with aversion to cold caused by affection of exogenous wind-cold, lossless, thin sputum of breathing with cough.

GUILONG KECHUANNING JIAONANG, main component is Ramulus Cinnamomi, Os Draconis, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Glycyrrhizae Preparata, Concha Ostreae, Rhizoma Coptidis, Rhizoma Pinelliae Preparatum, Pericarpium Trichosanthis, Semen Armeniacae Amarum (stir-fry).Function relieving cough and resolving phlegm, lowering the adverse-rising QI to subdue asthma.For the disease such as cough, asthma, accumulation and obstruction of sputum that affection of exogenous wind-cold, accumulation of phlegm-damp in the lung cause; Acute and chronic bronchitis is shown in above-mentioned patient.

Syrupus Bulbus Fritillariae Cirrhosae et Radix Saurauiae Tristylae: main component is Bulbus Fritillariae Cirrhosae fluidextract, Radix Platycodonis, Folium Eriobotryae, Mentholum.Function reducing heat and dispersing lung-QI, preventing phlegm from forming and stopping coughing.For wind-heat invading the lung, the cough expectorant Huang caused by stagnation of fire in the interior or ungratifying ejection of phlegm, laryngopharynx swelling and pain, distending pain uncomfortable in chest, cold cough and chronic bronchitis are shown in above-mentioned patient.

Tendril-leaved fritillary bulb cough-relieving reveals, and main component is Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, the Radix Stemonae, Radix Peucedani, Radix Platycodonis, Cortex Mori, Mentholum.Function cures mainly: eliminating phlegm and stopping cough.For cough due to lung-heat, abundant expectoration yellow skin.

MILIAN CHUANBEI PIPA GAO, main component is Radix Glehniae, Mentholum, Pericarpium Citri Reticulatae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Flos Farfarae, Folium Eriobotryae, Rhizoma pinelliae cordatae, Fructus Schisandrae Chinensis, aqua armeniacae.Function clearing heat and moistening lung, relieving cough and asthma, activating QI to eliminate phlegm.For the cough of the dryness of the lung, abundant expectoration, uncomfortable in chest, throat sufferings, hoarseness.

Intensified loquet distillate, main component is Folium Eriobotryae, Pericarpium Papaveris, the Radix Stemonae, Rhizoma Cynanchi Stauntonii, Cortex Mori, Radix Platycodonis, Mentholum.Function yin nourishing is astringed the lung, eliminating phlegm and stopping cough.For bronchitic cough.

Nourishing YIN and clearing away lung-heat cream, main component is Radix Rehmanniae, Radix Ophiopogonis, Radix Scrophulariae, Bulbus Fritillariae Cirrhosae, the Radix Paeoniae Alba, Cortex Moutan, Herba Menthae, Radix Glycyrrhizae.Function nourishing YIN to relieve dryness, removing heat from the lung and relieving sorethroat.For lung-dryness syndrome due to deficiency of YIN, pharyngodynia with dryness, the few expectorant of dry cough or sputum mixed with blood.

Lung clearing and phlegm eliminating pill, main component is Arisaema Cum Bile, bitter Fructus Pruni, Rhizoma Pinelliae Preparatum, Fructus Aurantii, Radix Scutellariae (wine is processed), Bulbus Fritillariae Cirrhosae, Herba Ephedrae (processing), Radix Platycodonis, Fructus Perillae Frutescentis, Semen Trichosanthis, Pericarpium Citri Reticulatae, Semen Raphani, Flos Farfarae (processing), Poria, Radix Glycyrrhizae.Function lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma.For cough due to lung-heat, abundant expectoration is breathed heavily, accumulation and obstruction of sputum, and lung qi is not smooth.

Mengshi Guntan Wan, main component is Lapis Chloriti (forging), Lignum Aquilariae Resinatum, Radix Scutellariae, Radix Et Rhizoma Rhei.Function lowering fire and expelling phlegm.Demonstrate,prove for excess-heat pertinacious phlegm.Send out as demented palpitation with fear, or palpitation with a distress feeling stupor, or breast wrist painful abdominal mass is vexed, or vertigo and tinnitus, or be insomnia, or strange dream, or cough with asthma expectorant is thick, constipation.Tongue fur strong yellow and thick, slippery and rapid pulse and strong.

What mostly adopt in these preparations is the Chinese medicine ingredients of heat-clearing and toxic substances removing, and action effect is slow, and some preparation is too much owing to taking number of times, and cause human body to produce certain resistance, action effect is more undesirable.

Summary of the invention

Main purpose of the present invention is to provide a kind of Chinese medicine preparation for antitussive, preparation method and application.Chinese medicine preparation of the present invention is used for antitussive, and evident in efficacy, utilization ratio is high.

The present invention solves the problems of the technologies described above by the following technical programs:

An object of the present invention is, provides a kind of Chinese medicine preparation of antitussive, and the raw material of the Chinese medicine preparation of described antitussive comprises following composition: Folium Perillae, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Fructus Aurantii and Radix Scutellariae.

Preferably, the raw material of the Chinese medicine preparation of described antitussive comprises each composition of following weight portion: Folium Perillae 144 parts, Radix Platycodonis 96 parts, 96 parts, Herba Ephedrae, Radix Peucedani 96 parts, Semen Armeniacae Amarum 2 parts, 72 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 96 parts, the Rhizoma Pinelliae 72 parts, 96 parts, Poria, Fructus Aurantii 96 parts and Radix Scutellariae 96 parts.

Preferably, the raw material of the Chinese medicine preparation of described antitussive also comprises each composition of following weight portion: Fructus Forsythiae 10-20 part, Rhizoma Coptidis 10-15 part, Pericarpium Citri Reticulatae Viride 10-15 part, Radix Et Rhizoma Rhei 5-10 part, Rhizoma Atractylodis 3-5 part, SHANZHIZI 3-5 part, Resina Ferulae 1-2 part.

Preferably, the raw material of the Chinese medicine preparation of described antitussive also comprises each composition of following weight portion: Fructus Forsythiae 15-20 part, Rhizoma Coptidis 10-12 part, Pericarpium Citri Reticulatae Viride 10-12 part, Radix Et Rhizoma Rhei 8-10 part, Rhizoma Atractylodis 3-5 part, SHANZHIZI 3-5 part, Resina Ferulae 1-2 part.

Preferably, the raw material of the Chinese medicine preparation of described antitussive also comprises each composition of following weight portion: Fructus Forsythiae 20 parts, Rhizoma Coptidis 10 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 8 parts, Rhizoma Atractylodis 4 parts, SHANZHIZI 4 parts, Resina Ferulae 1 part.

The present invention also provides a kind of described preparation method for the Chinese medicine preparation of antitussive, by the Folium Perillae of described raw material each component, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei and Rhizoma Atractylodis mixing, add hydrochloric acid solution to soak, steaming and decocting, obtain medicinal residues I and filtrate I, medicinal residues I is immersed in sodium hydroxide solution, steaming and decocting, filter, obtain filtrate II; Mixed by other components of described raw material, pulverize, infiltrate in alcoholic solution, heating decocts, and obtains medicinal residues III; By described medicinal residues III and water mixing, decoct, obtain filtrate II I, above-mentioned filtrate I, filtrate II and filtrate II I are mixed, filter, adjust pH is 5-7, obtains the described Chinese medicine preparation for antitussive.

Preferably, the volumetric concentration of described hydrochloric acid solution is 10-20%, the temperature of described steaming and decocting is 90-98 degree Celsius, the volumetric concentration of described alcoholic solution is 60-70%, by the Folium Perillae of described raw material each component, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei and Rhizoma Atractylodis mixing, the time adding hydrochloric acid solution immersion is 1-2 hour.

Preferably, before medicinal residues I is immersed in sodium hydroxide solution, also have the following steps, medicinal residues I and hydrochloric acid solution are soaked, steaming and decocting, and then the medicinal residues I obtained is immersed in sodium hydroxide solution.

Preferably, described raw material is obtained the mixing of other each components, pulverize, the order number of pulverizing is 30-40 order.

The present invention also provides the application of a kind of described Chinese medicine preparation for antitussive in the Chinese medicine preparation of preparation treatment gout.

Do for mentioned component and character thereof below and further illustrate as follows:

In the present invention, described Folium Perillae is the leaf of labiate wrinkle Folium Perillae, sharp Folium Perillae etc.Function cures mainly: deliver, and cold expelling is regulated the flow of vital energy, and battalion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement.And can solving toxin of fish and crab.For cold, fever with chills, headache nasal obstruction, double see cough or uncomfortable in chest relax person.This product can disperse exterior cold, opens lung qi dispersing gas, can with Rhizoma Zingiberis Recens with using.Have cough person concurrently, Chang Peiwu Semen Armeniacae Amarum, Radix Peucedani etc., as Apricot Kernel and Perilla Powder; If have stagnation of QI person uncomfortable in chest concurrently, polygamy 5 Rhizoma Cyperi, Pericarpium Citri Reticulatae etc. are as loose in revived.For stagnation of QI in spleen and stomach, uncomfortable in chest, the card of vomiting.This product tool promoting the circulation of QI to alleviate the stagnation in middle-JIAO, stomach function regulating preventing or arresting vomiting effect.Partially cold person, often uses together with Herba Pogostemonis; Partial heat person, can with Rhizoma Coptidis with using.Inclined stagnation of QI expectorant knot person, normal and the Rhizoma Pinelliae, Cortex Magnoliae Officinalis are used together.Again for vomiting during pregnancy, breast abdominal distention is vexed, and normal and Pericarpium Citri Reticulatae, Fructus Amomi compatibility, to strengthen its preventing or arresting vomiting, antiabortive effect.For take food fish Eriocheir sinensis and the stomachache caused, vomiting and diarrhoea, alone or join Rhizoma Zingiberis Recens, Radix Angelicae Dahuricae decoction." not Lu ": " the main therapeutic method to keep the adverse QI flowing downwards, except excessive cold invading middle-JIAO(the spleen and stomach).”

In the present invention, described Radix Platycodonis is the root of Campanulaceae Radix Platycodonis.Root is containing Saponin, and its composition known has Polygalacic acid, platycodigenin and glucose.-β-D-Glucose glycoside, Δ 7-stigmastenol, betulin is transplanted again containing chondrillasterol, α-Herba Spinaciae steroid, and containing inulin, platycodonin.Three triterpene class materials are obtained again: platycogenic acid A, B and C from Radix Platycodonis.Function cures mainly: open lung qi dispersing gas, evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain." herbal classic ": ", as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror for main chest and hypochondrium." " not Lu ": ", except cold and heat, migratory arthralgia, warming middle-JIAO rapid digestion of food, treats laryngopharynx pain for sharp the five internal organs the intestines and stomach, gas of enriching blood." " property of medicine opinion ": " and control the inferior dysentery, removing blood stasis, remove pneumatosis, removing food stagnancy gathers, sputum, and main lung-heat tachypnea is coughed inverse, except cold type of pain in abdomen, and main attacked by pestiferous factors and pediatric epilepsy scared." " Japan hanako materia medica ": " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken mass in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat." 7. Li Gao: " sharp chest and diaphragm, (controlling) throat gas is stopped up and pain, broken stagnant gas and long-pending block, (removing) pulmonary wind heat, the clear sharp head, sharp key." clinical practice: Radix Platycodonis, except with except treating respiratory system disease, also often controls other system pathological changes in recent years, and Rhizoma Atractylodis Radix Platycodonis decoction treatment child virus and dyspeptic enteritis, obtain satisfactory effect; Radix Et Rhizoma Rhei Radix Platycodonis composition Radix Et Rhizoma Rhei Radix Platycodonis decoction, boiled water is taken after being infused in hot water or decoction, and controls dysuriac 68 example caused by antipsychotic drug, only has 4 examples invalid; Get Radix Platycodonis, Radix Angelicae Sinensis, ligusticum wallichii decoction piece decoction, make oil/water Emulsion, wipe facial rash place, treatment chloasma has true effect.

In the present invention, described Herba Ephedrae is the root and rhizome of Ephedraceae plant plait Herba Ephedrae or ephedra equisetina or epheday intermedia.Function cures mainly: control body empty spontaneous perspiration, night sweat.TAO Hong-Jing: " hidroschesis, Xia Yue powder of mixing uses it." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " and hidroschesis, shows gas in fact, Gu empty, and the lung qi that disappears, globus hystericus.”

In the present invention, described Radix Peucedani is the root of samphire Peucedanum praeruptorum DUNN or RADIX PEUCEDANI.Function cures mainly: dispelling wind-heat, the therapeutic method to keep the adverse QI flowing downwards, expectorant.Control headache due to pathogenic wind-heat, expectorant heat syndrome cough is breathed heavily, vomiting, and chest and diaphragm is full vexed." not Lu ": " painful abdominal mass in the full breast side of body of main treatment expectorant, stagnation of QI in chest and abdomen, wind headache, goes expectorant real, the therapeutic method to keep the adverse QI flowing downwards.Cure the wound cold and heat, pushes away Chen Zhixin, improving eyesight benefit essence." " property of medicine opinion ": " and reality of reducing phlegm and internal heat, the therapeutic method to keep the adverse QI flowing downwards, the inside and outside all heat of main seasonal epidemic pathogens, singly boil take good.”

In the present invention, described Semen Armeniacae Amarum is the seed of rosaceous plant Fructus Pruni Prunus armeniaca L..Function cures mainly: sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation., dryness of the intestine constipation withered for cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin.Choosing side: control lung cold soldier cough: Herba Asari half two (smashing as end), Semen Armeniacae Amarum half two (soup soaks, peeling point, two core, and the micro-Huang of parched with bran, grinds as cream).Medicine-feeding, dewaxing half two in pan, secondary lower crisp one point, enter Herba Asari, Semen Armeniacae Amarum, ball is as large in sheep Fructus Jujubae.When disregarding, wrap up in a ball with silk floss, containing changing pharynx Tianjin.(Holy Benevolent Prescriptions)

In the present invention, described Radix Glycyrrhizae is root and the root stock of glycyrrhizic legume.Function cures mainly: with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis." herbal classic ": " longue meat, times power, incised wound swells, removing toxic substances for main the five internal organs six mansion cold and heat pathogen, hard muscles and bones." " not Lu ": " warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, quenches the thirst, qualcomm meridian, and sharp vim and vigour separate hundred poison of drug.”

In the present invention, described Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange and variety thereof.Chinese Pharmacopoeia is recorded, Pericarpium Citri Reticulatae: often shell into several lobe, base portion is connected, and what have is irregular lamellar, thick 1 ~ 4mm.Orange red or the rufous of outer surface, has fine wrinkle and recessed point-like grease chamber; Inner surface ivory buff, coarse, attached yellow-white or yellowish-brown grain shape vascular bundle.Matter is slightly hard and crisp.Gas is fragrant, acrid in the mouth, hardship.Pericarpium citri reticuatae chachiensis: normal 3 lobes are connected, shape neat, thickness is even, about lmm.Point-like grease chamber is comparatively large, looks illumination, transparent clear.Matter is more soft.

In the present invention, the described Rhizoma Pinelliae is the tuber of the aroid Rhizoma Pinelliae.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness.Outer subduing inflammation., vomiting regurgitation dizzy for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, interior expectorant, breast gastral cavity painful abdominal mass are vexed, globus hystericus disease; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI." herbal classic ": " therapeutic method to keep the adverse QI flowing downwards, laryngopharynx swells and ache, and dizziness breast is swollen, cough with dyspnea, borborygmus, hidroschesis for main typhoid fever cold and heat, hardness in the epigastrium.”

In the present invention, described Poria, be the dry sclerotia of Polyporaceae plant Poria, function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful." herbal classic ": " the inverse gas of the main breast side of body, melancholy is angerd frightened heresy and probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, the burnt dry tongue of mouth, diuresis.”

In the present invention, described Fructus Aurantii is the mellow fruit nearly such as rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn., fragrant circle or Citrus aurantium L. var. amara Engl..Function cures mainly: dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse." property of medicine opinion ": " control rubella all over, dislike and itch, main hemorrhoidal hamorrhage haemorrhoids, stagnation of QI in chest and abdomen in flesh as numb bean, the swollen void of two sides of body, pass diaphragm is congested.”

In the present invention, described Radix Scutellariae is the root of labiate Radix Scutellariae.Function cures mainly: removing the relative excess fire, except damp and hot, and hemostasis, antiabortive.Control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle." herbal classic ": " main all hot jaundice, intestinal Bleach, lets out profit, relieves oedema or abdominal distension through diuresis or purgation, and hematochezia closes, (controlling) malignant boil, and cellulitis is lost, acute scleritis.”

In the present invention, described Fructus Forsythiae is the fruit of Oleaceae plants Fructus Forsythiae, and fruit is containing forsythol, sterol compound, Saponin (without hemolytic) and Flavonoids, horse tongue resinol glycoside etc.Peel is containing oleanolic acid.Blue or green Fructus Forsythiae contains Saponin 4.89%, alkaloid 0.2%.Function cures mainly: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction." Japan hanako materia medica ": " logical small intestinal, evacuation of pus.Control furuncle, pain relieving, logical menstruation." " herbal classic ": " main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat." " property of medicine opinion ": " main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat." Li Gao: " loose all menses stagnation of QI gather; Detumescence." about compatibility and incompatibility of drugs, " Bencao Jingshu ": " carbuncle the sixth of the twelve Earthly Branches bursts and do not take, and large heat does not take due to empty person, and weakness of spleen and stomach is easy to the person of letting out and does not take.”

In the present invention, described Rhizoma Coptidis, (Classification system: Coptis chinensis Franch.) is called: taste company, Rhizoma Coptidis, Rhizoma Coptidis, belongs to Ranunculaceae, Coptis herbaceos perennial, phyllopodium is hesitated, hard papery, ovum shape triangle, three totally cleave, central authorities' sliver ovum shape rhombus, pinniform drastic crack, there is sharp sawtooth at edge, and the raw sliver in side does not wait 2 drastic cracks; The long 5-12cm of petiole.Shennong's Herbal: bitter in the mouth, cold.Cure mainly steam, ophthalmalgia, the corner of the eyes is hindered, delacrimation, improving eyesight, intestinal Bleach, and stomachache, dysentery, swells and ache in married woman's the moon.Clothes of a specified duration make us not forgetting.Rhizome is containing berberine (berberine) 5.56% ~ 7.25%, coptisine (coptisine), epiberberine (epiberberine), berberrubine (berberrubine), palm leaf coculine (palmatine), Columbamine (columbamine), jateorhizine (jatrorrhizine), 13-methyl-.psi.-coptisine. (worenine), Flos Magnoliae Liliflorae subtracts (magnoflorine), ferulic acid (ferulic acid), obacunone (obakunone), obakulactone (obakulactone).

In the present invention, described Pericarpium Citri Reticulatae Viride is the peel or the young fruit that do not become heat of multiple Fructus Citri tangerinae class such as Folium Symplocoris Caudatae profit plant tangerine produced in fujian province or Zhu's Fructus Citri tangerinae etc.Various Pericarpium Citri Reticulatae Viride all containing volatile oil, and contains flavonoid glycoside etc. more.Function cures mainly: soothing the liver dispelling the stagnated QI, eliminating stagnation expectorant.Control breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction block." Bencao Tujing ": " the main stagnation of QI, lower food, removing mass knot and diaphragm gas "." medicine origin ": " " curing mainly secret formula " cloud, dividing of the moon of fainting, few sun illly uses it.Broken hard addiction, loose stagnant gas, go the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels all wet, left flank has pneumatosis ".

In the present invention, described Radix Et Rhizoma Rhei is the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Another name: general, Huang Liang, fire ginseng, skin as, another name for Sichuan Province Radix Et Rhizoma Rhei, Radixet Rhizoma Rhei, cow tongue Radix Et Rhizoma Rhei, bright and beautiful stricture of vagina, raw army, Radix Et Rhizoma Rhei.Nature and flavor: bitter, cold.Gui Jing: spleen, stomach, large intestine, liver, pericardium channel.Section belongs to classification: Polygonaceae.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances." WU Pu Bencao ": the legendary god of farming, Thunder God: bitter, poisonous." book on Chinese herbal medicine is through separating ": enter small intestine meridian, heart channel of Hand-Shaoyin.Triple energizer meridian, double enter the stomach channel of foot-Yang-ming, the large intesting channel of Hand-Yangming.Function cures mainly: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood bleeder is had for heat in blood.

In the present invention, described Rhizoma Atractylodis are the rhizome of feverfew RHIZOMA ATRACTYLODIS IANCEAE or Atractylis chinensis etc., and RHIZOMA ATRACTYLODIS IANCEAE rhizome is containing volatile oil about 5 ~ 9%.Main body of oil is atractylol, hinesol, sagittol etc.Atractylis chinensis rhizome is containing volatile oil 1.5%, and its main component is atractylol, atractylone, hinesol and eudesmol etc.East Rhizoma Atractylodis rhizome is containing volatile oil 1.5%, and its main component is atractylol, hinesol, sagittol, Rhizoma Atractylodis furan feed hydrocarbon, atractylone.Function cures mainly: spleen invigorating, dampness, resolving depression, wards off dirty.Control wet Sheng and be stranded spleen, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, and seasonal epidemic pathogens is caught a cold, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia." beautiful Chinese catalpa medicine solution ": " dry native diuretic, lets out drink expectorant, clots absorbing, dissipating depression of QI, goes Lou, changes tinea ， Chu Disorder, and reason acid regurgitation removing the necrotic tissue, ward off mountains and rivers communicable subtropical diseases, the flaccidity returning muscles and bones is soft, excessive muddiness of urinating clearly." " detailed outline ": " control damp-phlegm prolonged fluid-retention, or hold blood stasis under the arm and become nest capsule, and spleen wets dirty, turbid drop leukorrhagia, slidingly rush down hemorrhoidal hamorrhage.”

In the present invention, described SHANZHIZI is the fruit of Maguireothamnus speciosus Fructus Gardeniae, containing flavonoid gardenin, pectin, tannin, crocin, crocetin, PEARLITOL 25C, nonacosane, cupreol.The another glycoside containing the smelly formaldehyde structure of multiple tool ring: gardenoside, geniposide pool element-1-glycoside, lattice Tegosept P-1-β-D-gentiobioside and shanzhiside in a small amount.Function cures mainly: heat clearing away, pathogenic fire purging, removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Property of medicine opinion ": “ Sha female ground beetle poison, reduce phlegm and internal heat malicious wind, sharp five types of stranguria, main attacked by pestiferous factors, diuresis, separates five kinds of jaundice, improving eyesight, disease heat extraction and xerostomia of quenching one's thirst when controlling, conjunctival congestion and swelling pain ".

In the present invention, described Resina Ferulae, another name: RESINA FERULAE, spire Resina Ferulae, Latin literary fame: Ferula teterrimaKar.et Kir., Umbelliferae, Ferula plant.Function cures mainly: removing food stagnancy, parasite killing.Control lump in the abdomen mass in the abdomen, malnutrition due to parasitic infestation, meat amasss, trusted subordinate's cold type of pain, malaria, dysentery.1. Tang Materia Medica: master kills all small worms, gas of deodorizing, broken disease is amassed, lower bad odor." mouth China son book on Chinese herbal medicine ": control biography corpse, broken disease addiction, cold air, wards off temperature, treating malaria, main cholera cardiac and abdominal pain of holding concurrently, kidney qi, warm miasma, all gill fungus dish poison imperial.

Agents useful for same of the present invention and raw material are all commercially.

Beneficial effect of the present invention is: the Chinese medicine preparation for antitussive of the present invention farthest can decrease the effect of mutual antagonism between Chinese medicine component, makes Chinese medicine component have synergism each other.

Chinese medicine preparation for antitussive of the present invention is that a kind of drug effect is definite, toxic and side effects is little, not easily produces the Chinese medicine preparation of drug resistance.Various suitable dosage form can be made as required, such as granule, pill, powder, electuary, unguentum, tablet etc.

Chinese medicine preparation for antitussive of the present invention is high to medical material bioavailability, and adopt advanced detection method, steady quality, improves drug effect, reduces the dosage of medicament simultaneously.

Chinese medicine preparation for antitussive of the present invention, is easy to people and takes absorption, is that a kind of drug effect is definite, toxic and side effects is little, not easily produces the Chinese medicine preparation of drug resistance.Compared with former preparation, decrease the cooking stove required for Herb-decocting Method, save time and energy, particularly more and more faster to society rhythm of life, when except increasing people needs to leave home, this technology have passed the top expert testimony of Chinese herbal medicine industry, and former basis of grinding medicine has breakthrough use value.

Detailed description of the invention

Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.

Raw material and the content thereof of the Chinese medicine preparation for antitussive of embodiment 1-4 are as shown in table 1.

The raw material of table 1 embodiment and content thereof

The preparation method of the Chinese medicine preparation for antitussive of embodiment 1-4 is:

By the Folium Perillae of described raw material each component, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei and Rhizoma Atractylodis mixing, add the hydrochloric acid solution immersion that volumetric concentration is 10%, soak time is 1-2 hour, steaming and decocting, boiling temperature is 90-98 degree Celsius, obtain medicinal residues I and filtrate I, medicinal residues I being immersed in again volumetric concentration is in the hydrochloric acid solution of 10%, steaming and decocting, boiling temperature is 90-98 degree Celsius, and then the medicinal residues I obtained is immersed in volumetric concentration is in the sodium hydroxide solution of 60-70%, steaming and decocting, boiling temperature is 90-98 degree Celsius, filter, obtain filtrate II, by other each components of described raw material, i.e. Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Fructus Aurantii, Radix Scutellariae, Pericarpium Citri Reticulatae Viride, SHANZHIZI and Resina Ferulae mixing, pulverize, the order number of pulverizing is 30-40 order, infiltrates in alcoholic solution, and heating decocts, and obtains medicinal residues III, by described medicinal residues III and water mixing, decoct, obtain filtrate II I, above-mentioned filtrate I, filtrate II and filtrate II I are mixed, filter, adjust pH is 5-7, obtains the described Chinese medicine preparation for antitussive.

Embodiment 5

Conventionally Chinese medicine preparation of the present invention is made various suitable dosage form, such as granule, pill, powder, electuary, unguentum, tablet etc.

Embodiment 6

Method of administration and the course for the treatment of:

The granule of the Chinese medicine preparation of the oral embodiment of the present invention 1,2,3 or 4, each 3 times, each 0.2g one day is a course for the treatment of, oral 1-5 course for the treatment of.

Embodiment 7

The application of Chinese medicine preparation for antitussive of the present invention in the Chinese medicine preparation of preparation treatment gout.

Liu * *, female, 56 years old, people from Hangzhou, suffers from gouty arthritis 13 years, long-term taking probenecid, the drug withdrawal because of anaphylaxis, nearly 1 year with the slow pain of colchicine, blood uric acid at about 250umol/l, joint pain swelling, dysstasia, after taking this medicine, two finger-joint rednesses disappear, and knee joint can be squatted down.

Embodiment 8

Observation of curative effect for antitussive is tested:

Select the age 8-50 year between, and inform product function of the present invention cure mainly and contingent discomfort reaction.Have 300 volunteers to participate, wherein male 100 example, women 200 example, volunteer must suffer from slight or more cough, and other patients can not participate in this experiment.

Experiment grouping: be divided into embodiment 1-4, comparative example 1 and reference example 1, often organize 50 people.According to embodiment 6 method of administration and take the course for the treatment of.Embodiment 1-4 takes medicine prepared by embodiment 1-4, comparative example 1 for taking common cold medicine, i.e. SHUANGHUANGLIAN KOUFUYE; Reference example 1 does not take any medicine.

Treatment effectiveness evaluation:

Cure: all transference cures of coughing, without any unconformable sensation.

Effective: cough symptom disappears substantially, only have basic irrelevant not recovering, such as tone color etc.

Effective: cough symptom disappears substantially, but part is thoroughly not good, and as tone color, pharyngeal idol has discomfort, an accidental sound cough etc.

Invalid: cough symptom still exists, without any change.

Observed result is shown in Table 1.

Table 1 affects information slip to cough

Table 1 result shows,

The cure rate of the embodiment 1-4 of medicine of the present invention is between 64-70%, and effective percentage ratio is between 30-32%, and healing and effective ratio are more than 92%.The cure rate of comparative example 1 is 54%, and obvious effective rate is 24%, and effective percentage is 14%, and inefficiency is 8%.The cure rate of reference example is 0%, and obvious effective rate is 10%, and effective percentage is 8%, and inefficiency is 82%.

Above-mentioned conclusion display, Chinese medicine preparation of the present invention has the effect for the treatment of cough, and successful is better than existing general cold-treating preparation, has synergism between each component of product of the present invention.

Embodiment 8

Case selection

Meet constitutional gouty arthritis criteria for classification, get rid of acute gout arthritis simultaneously; 2) age person between 18-70 year, male or female; 3) medicine do not taken other uric acid resisting medicines and affect uric acid metabolism and excretion reaches more than 1 week.

Diagnostic criteria

Adopt in " the clinic diagnosis guide rheumatism fascicle " of Chinese Medical Association's promulgation in 2010 " Primary Gouty Arthritis criteria for classification ".

1. specificity urate crystal is had in joint fluid, or 2. chemically or in the tophus of micropolariscope confirmation contain urate crystal, or 6: the A. acute arthritis outbreak 3. possessed in following 12 (clinical, laboratory, x line performance) exceedes once; B. inflammatory reaction reached peak in one day; C. monarthritis outbreak; D. visible joint local is rubescent; E. first to hesitate toe joint pain or swelling; F. one-sided first open up toe joint and get involved; G. one-sided osteoarthrosis of staggering is got involved; H. suspicious tophus; I. hyperuricemia; J. unsymmetry intraarticular swelling (confirmation of x line); K. under cortical bone cyst without bone erosion (confirmation of x line); L. during arthritis outbreak, the culture of joint fluid is negative.First with reference to above-mentioned diagnostic criteria, patient diagnosed has gout, and raises (male and postmenopausal women >420umol/L, Pre-menopausal Women >350umol/L) with blood uric acid.Get rid of acute gout arthritis, namely 1. pain Progressive symmetric erythrokeratodermia increases the weight of simultaneously, reaches peak at 12 hours, is difficult to stand: 2. scorching hot, the function limitation of affected joints redness, tenderness are all clearly.

3, curative effect determinate standard

Employing comprehensive therapeutic effect is evaluated: (" new Chinese medicine guideline of clinical investigations " with reference to health ministry is issued)

Clinical recovery: the total mark of arthralgia, tenderness, acute redness, limitation of activity declines 100%.

Effective: the total mark of arthralgia, tenderness, acute redness, limitation of activity declines >=66%.

Effective: the total mark of arthralgia, tenderness, acute redness, limitation of activity declines >=33% and < 66%.

Invalid: the total mark decline <33% of arthralgia, tenderness, acute redness, limitation of activity.

Note: computing formula (nimodipine method): integration minimizing percentage ratio=(treat front integration one and treat rear integration)/

Integration * 100% before treatment.

Take the Chinese medicine preparation that embodiment 1 to 4 prepares, 1 time on the 1st; Matched group allopurinol tablet 0.1g, 2 times/day; Treat March altogether.

The present invention treats the Chinese medicine of gout can effective uric acid resisting, reduces gout recurrence, can alleviate more rapidly gout symptom than existing medicine.

In sum; be only preferred embodiment of the present invention; not to any formal and substantial restriction of the present invention; should be understood that; for those skilled in the art; under the prerequisite not departing from the inventive method, also can make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.All those skilled in the art, without departing from the spirit and scope of the present invention, a little change made when utilizing disclosed above technology contents, the equivalent variations of modifying and developing, be Equivalent embodiments of the present invention; Meanwhile, all according to substantial technological of the present invention to the change of any equivalent variations that above-described embodiment is done, modify and differentiation, all still belong in the scope of technical scheme of the present invention.

Claims (10)

1. for a Chinese medicine preparation for antitussive, it is characterized in that, the raw material of the Chinese medicine preparation of described antitussive comprises following composition: Folium Perillae, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Poria, Fructus Aurantii and Radix Scutellariae.

2. as claimed in claim 1 for the Chinese medicine preparation of antitussive, it is characterized in that, the raw material of the Chinese medicine preparation of described antitussive comprises each composition of following weight portion: Folium Perillae 144 parts, Radix Platycodonis 96 parts, 96 parts, Herba Ephedrae, Radix Peucedani 96 parts, Semen Armeniacae Amarum 2 parts, 72 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 96 parts, the Rhizoma Pinelliae 72 parts, 96 parts, Poria, Fructus Aurantii 96 parts and Radix Scutellariae 96 parts.

3. as claimed in claim 1 or 2 for the Chinese medicine preparation of antitussive, it is characterized in that, the raw material of the Chinese medicine preparation of described antitussive also comprises each composition of following weight portion: Fructus Forsythiae 10-20 part, Rhizoma Coptidis 10-15 part, Pericarpium Citri Reticulatae Viride 10-15 part, Radix Et Rhizoma Rhei 5-10 part, Rhizoma Atractylodis 3-5 part, SHANZHIZI 3-5 part, Resina Ferulae 1-2 part.

4. as claimed in claim 1 or 2 for the Chinese medicine preparation of antitussive, it is characterized in that, the raw material of the Chinese medicine preparation of described antitussive also comprises each composition of following weight portion: Fructus Forsythiae 15-20 part, Rhizoma Coptidis 10-12 part, Pericarpium Citri Reticulatae Viride 10-12 part, Radix Et Rhizoma Rhei 8-10 part, Rhizoma Atractylodis 3-5 part, SHANZHIZI 3-5 part, Resina Ferulae 1-2 part.

5., as claimed in claim 1 or 2 for the Chinese medicine preparation of antitussive, it is characterized in that, the raw material of the Chinese medicine preparation of described antitussive also comprises each composition of following weight portion: Fructus Forsythiae 20 parts, Rhizoma Coptidis 10 parts, 10 parts, Pericarpium Citri Reticulatae Viride, Radix Et Rhizoma Rhei 8 parts, Rhizoma Atractylodis 4 parts, SHANZHIZI 4 parts, Resina Ferulae 1 part.

6. the preparation method of the Chinese medicine preparation for antitussive as described in any one of claim 1-5, it is characterized in that, by the Folium Perillae of described raw material each component, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei and Rhizoma Atractylodis mixing, add hydrochloric acid solution to soak, steaming and decocting, obtains medicinal residues I and filtrate I, medicinal residues I is immersed in sodium hydroxide solution, steaming and decocting, filters, obtains filtrate II; Mixed by other components of described raw material, pulverize, infiltrate in alcoholic solution, heating decocts, and obtains medicinal residues III; By described medicinal residues III and water mixing, decoct, obtain filtrate II I, above-mentioned filtrate I, filtrate II and filtrate II I are mixed, filter, adjust pH is 5-7, obtains the described Chinese medicine preparation for antitussive.

7. as claimed in claim 6 for the preparation method of the Chinese medicine preparation of antitussive, it is characterized in that, the volumetric concentration of described hydrochloric acid solution is 10-20%, the temperature of described steaming and decocting is 90-98 degree Celsius, the volumetric concentration of described alcoholic solution is 60-70%, by the Folium Perillae of described raw material each component, Radix Platycodonis, Herba Ephedrae, Radix Peucedani, Semen Armeniacae Amarum, Radix Glycyrrhizae, Fructus Forsythiae, Rhizoma Coptidis, Radix Et Rhizoma Rhei and Rhizoma Atractylodis mixing, the time adding hydrochloric acid solution immersion is 1-2 hour.

8. the preparation method of the Chinese medicine preparation for antitussive as claimed in claims 6 or 7, is characterized in that, before being immersed in sodium hydroxide solution by medicinal residues I, also have the following steps, medicinal residues I and hydrochloric acid solution are soaked, steaming and decocting, and then the medicinal residues I obtained is immersed in sodium hydroxide solution.

9. the Chinese medicine preparation for antitussive as claimed in claims 6 or 7, is characterized in that, mixed by other components of described raw material, and pulverize, the order number of pulverizing is 30-40 order.

10. the application of the Chinese medicine preparation for antitussive as described in any one of claim 1-5 in the Chinese medicine preparation of preparation treatment gout.