CN104435152A - Traditional Chinese medicine agent with functions of tranquilizing and allaying excitement for treating stage I of hypertension and preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine agent with functions of tranquilizing and allaying excitement for treating stage I of hypertension. The traditional Chinese medicine agent is prepared from the following main raw materials in parts by weight: 10-20 parts of Chinese thorowax root, 9-12 parts of hiraute shiny bugleweed herb, 6-10 parts of paniculate swallowwort root, 8-15 parts of baical skullcap root, 9-12 parts of codonopsis pilosula, 6-10 parts of poria cocos, 5-9 parts of dragon bone, 9-15 parts of sheep's or goat's horn, 5-9 parts of raw oysters, 7-12 parts of emblic leafflower fruit, 5-10 parts of rhubarb stir-fried with wine and 9-15 parts of red ocher. The traditional Chinese medicine agent disclosed by the invention can meet the theories of treating hypertension by the traditional Chinese medicine, has the effects of tonifying qi and nourishing the kidneys, nourishing the liver and the kidneys, and nourishing the heart and tranquilizing mind, is suitable for curing various hypertension, is particularly suitable for curing the stage I of hypertension, is significant in curative effect, and cannot cause side effects.

Description

Hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia and method for making

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia and method for making.

Background technology

Hypertension or Arterial Hypertention are the chronic diseases that a kind of arteriotony raises.The rising of blood pressure makes heart promotion blood increase in the burden of Ink vessel transfusing circulation time.Blood pressure has two kinds, systolic pressure and diastolic pressure, measured value when being respectively heartbeat when muscle contraction or diastole.The blood pressure standard used according to World Health Organization's suggestion is: all adult normal's systolic pressures should be less than or equal to 140mmHg (18.6kPa), and diastolic pressure is less than or equal to 90mmHg (12kPa).That is systolic pressure is between 141-159mmHg (18.9-21.2kPa), diastolic pressure, between 91-94mmHg (12.1-12.5kPa), is borderline hypertension.During office hypertension, necessary repetitive measurement blood pressure, has at least the meansigma methods of double diastolic pressure just can be diagnosed as hypertension at 90mmHg (12.0kPa) or more.Only a blood pressure rising person still can not make a definite diagnosis, but needs follow-up observation.

The hypertension clinical stages standard of China's revision in 1979, by clinical manifestation, was divided into for three phases by hypertension.First phase blood pressure reaches Definite Hypertension level, and the diastolic pressure most of the time, fluctuation was between 12.0-13.3kPa (90-100mmHg), can recover normal after rest, clinically acardia, brain, the performance of kidney complication.Second phase blood pressure reaches Definite Hypertension level, diastolic pressure is more than more than 13.3kPa (100mmHg), can not be down to normal after rest, and have a person in the following: 1. x-ray, electrocardiogram or echocardiography, has the sign of left ventricular hypertrophy; 2. examination of ocular fundus, is shown in and has skull bottom artery generally or locally to narrow; 3. albuminuria and (or) creatinine concentration of plasma slightly raise.Three phase blood pressures reach Definite Hypertension level, and diastolic pressure more than 14.7-16.0kPa (110-120mmHg), and has a person in the following: 1. cerebrovas-cularaccident or hypertensive encephalopathy; 2. left heart failure; 3. renal failure; 4. retinal hemorrhage or ooze out, has or without papilloedema.Radical type malignant hypertension, the state of an illness sharply develops, and diastolic pressure often continues at more than 17.3kPa (130mmHg), and has retinal hemorrhage, oozes out or papilloedema.Visible, the internal organs such as first phase hypertension heart and brain kidney there is no and suffer damage; Second phase hypertension has the sign of heart and brain kidney mild damage or single target organ damage, but still is in the organ dysfunction compensatory stage; And three phase hypertension heart and brain kidney organs damage seriously, and lose compensatory capacity.

At present, treating hypertensive medicine has a lot, the one that patent document discloses of publication number CN 103071062 A (application number 201310047710.5) treats hypertensive Chinese medicine, is prepared from by the Chinese crude drug of following weight: Radix Rehmanniae 15g, Radix Rehmanniae Preparata 12g, Semen Platycladi 12g, Rhizoma Dioscoreae 10g, Radix Paeoniae Alba 24g, Radix Achyranthis Bidentatae 24g, Haematitum 18g, Os Draconis 12g, Concha Ostreae 12g, Rhizoma Polygonati 10g, Radix Angelicae Sinensis 8g, Radix Bupleuri 6g, Rhizoma Gastrodiae 8g, Radix Codonopsis 10g, Rhizoma Atractylodis Macrocephalae 8g, Poria 10g, Rhizoma Alismatis 18g, Pericarpium Citri Reticulatae 8g, Ramulus Uncariae Cum Uncis 8g, Rhizoma Pinelliae Preparatum 6g, Flos Chrysanthemi 8g, Fructus Gardeniae 8g.The one that patent document discloses of publication number CN 102940786 A (application number 201210381256.2) treats hypertensive Chinese medicine, be made up of following component, the weight portion of each component is: Radix Rehmanniae 10-12, Herba Epimedii 1-3, Rhizoma Coptidis 10-12, Os Draconis 10-12, Fructus Crataegi (parched to brown) 10-12, Radix Panacis Quinquefolii 3-5, Fructus Lycii 10-12, Fructus Mori 10-12, Radix Ilicis Asprellae 10-12, Retinervus Luffae Fructus 8-10, Radix Saposhnikoviae 8-10, Ramulus Uncariae Cum Uncis 8-10, CUIYUNCAO 10-12, Rhizoma Gastrodiae 8-10, Cacumen Securinegae Suffruticosae 5-8, Concha Ostreae 10-12, Fructus Rosae Laevigatae 8-10, Folium Mori 10-12.Publication number CN 103083575 A(application number 201310062344.0) the one that patent document discloses treat hypertensive medicine, described medicine gram to be made up of by weight following raw materials according: Radix Paeoniae Alba 10-30 gram, Cortex Eucommiae (parched) 10-30 gram, Cortex Phellodendri 5-15 gram, Fructus Crataegi 10-30 gram, Radix Rehmanniae Preparata 5-15 gram, Pheretima 5-15 gram, Folium Bambusae 5-15 gram, Radix Glycyrrhizae 5-15 gram, Pollen Typhae 5-15 gram, Flos Chrysanthemi 5-15 gram, Semen Cassiae 5-15 gram, Radix Salviae Miltiorrhizae 10-20 gram, Radix Polygoni Multiflori 10-20 gram, Fructus Lycii 5-15 gram, Spica Prunellae 10-20 gram, Fructus Sophorae 5-15 gram, Herba Apocyni veneti 10-20 gram, Ramulus Uncariae Cum Uncis 5-15 gram, Radix Achyranthis Bidentatae 5-15 gram, Calculus Bovis 5-15 gram, Borneolum Syntheticum 2-8 gram, Radix Gentianae 2-8 gram, Radix Angelicae Sinensis 5-15 gram.

Also there is many deficiencies in the prior art comprising above-mentioned patent documentation in treatment hypertension, at present in hypertensive treatment, people widely use various Western medicine, and doctor trained in Western medicine can only control to some extent hypertension, can not thoroughly cure, be usually to take medicine all the life, this has not only increased the weight of the burden of patient greatly but also long-term taking also can have side effects.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, and adopt Chinese crude drug comparatively common in the localities as raw material, each raw material of Chinese medicine is through dialectical compatibility.Another object of the present invention is just to provide the preparation method of above-mentioned hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, takes off the primary raw material stating weight proportion and is prepared from: Radix Bupleuri 10-20 part; Herba Lycopi 9-12 part; Radix Cynanchi Paniculati 6-10 part; Radix Scutellariae 8-15 part; Radix Codonopsis 9-12 part; Poria 6-10 part; Os Draconis 5-9 part; Cornu Caprae seu Ovis 9-15 part; Concha Ostreae 5-9 part; Fructus Phyllanthi 7-12 part; Radix et Rhizoma Rhei (stir-fried with wine) 5-10 part; Haematitum 9-15 part.

Hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Bupleuri 13-17 part; Herba Lycopi 10-11 part; Radix Cynanchi Paniculati 7-9 part; Radix Scutellariae 10-13 part; Radix Codonopsis 10-11 part; Poria 7-9 part; Os Draconis 6-8 part; Cornu Caprae seu Ovis 11-13 part; Concha Ostreae 6-8 part; Fructus Phyllanthi 8-11 part; Radix et Rhizoma Rhei (stir-fried with wine) 6-9 part; Haematitum 11-13 part.

Hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Radix Bupleuri 15 parts; Herba Lycopi 10.5 parts; Radix Cynanchi Paniculati 8 parts; Radix Scutellariae 11 parts; Radix Codonopsis 10.5 parts; 8 parts, Poria; Os Draconis 7 parts; Cornu Caprae seu Ovis 12 parts; Concha Ostreae 7 parts; Fructus Phyllanthi 9 parts; Radix et Rhizoma Rhei (stir-fried with wine) 7 parts; Haematitum 12 parts.

Present invention also offers the preparation method above-mentioned hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia being made pharmaceutically acceptable decoction, injection, capsule and tablet.

The preparation method of described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia decoction, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct and (preferably, decoct 43-47 minute in 40-50 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction (preferably, decocts 33-37 minute in 30-40 minute, be more preferably, decoct 35 minutes), merging filtrate, is concentrated into 1/2 of original volume;

(4) Radix Bupleuri, Radix Scutellariae and Radix Codonopsis are cut into slices, the ethanol adding the 20%-30% of 6-10 times amount makees solvent, dipping, percolation, collect percolate, leave standstill 3-5 hour (preferred, leave standstill 3.5-4.5 hour, be more preferably, leave standstill 4 hours), filter, filtrate recycling ethanol is extremely without alcohol taste;

(5) by even for step (3)-(4) gained liquid mixing, the correctives sucrose adding the 5%-10% being equivalent to mixed liquor quality is (preferred, add the correctives sucrose of the 6%-9% being equivalent to mixed liquor quality, be more preferably, add be equivalent to mixed liquor quality 8% correctives sucrose), sterile packaged.

According to preparation method recited above, preferred scheme is: the ethanol that step (4) adds the 23%-27% of 7-9 times amount makees solvent (preferred, the ethanol adding 25% of 8 times amount makees solvent).

Instructions of taking: each 8-10ml, every day 3 times, 15 days courses for the treatment of.

The preparation method of described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia injection, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) by Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct 40-50 minute (preferably, decoct 43-47 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction 30-40 minute is (preferred, decoct 33-37 minute, be more preferably, decoct 35 minutes), merging filtrate, being condensed into relative density is 1.20-1.30(45 DEG C) thick paste (preferred, be condensed into the thick paste that relative density is 1.23-1.27, be more preferably, be condensed into the thick paste that relative density is 1.25), dry, be ground into fine powder,

(4) by Radix Bupleuri, Radix Scutellariae and Radix Codonopsis section, water extraction twice, boil 50-60 minute (preferably at every turn, boil 53-57 minute at every turn, be more preferably, boil 55 minutes) at every turn, twice filtrate merges, add the ethanol of 3-7 20%-30% doubly, abundant stirring, put on cloth funnel and be separated, discard ethanol mother liquor, add lead acetate (preferred, be equivalent to the lead acetate of the 4%-6% of crude drug amount, add after being made into the solution of 15%-25%, be more preferably, be equivalent to the lead acetate of 5% of crude drug amount, add after being made into the solution of 20%), abundant stirring, precipitation separation, drip sodium carbonate, regulate pH to 6.0-7.0(preferred, regulate pH to 6.3-6.7, be more preferably, regulate pH to 6.5), dry,

(5) step (3)-(4) gains are got, by recipe quantity add water for injection dissolve, adjust pH to 6.5, with charcoal treatment once, suction strainer, add to the full amount of water for injection, use glass funnel fine straining, be sub-packed in 2 milliliters or 10 milliliters of ampoules, sterilizing 30 minutes is (preferred, sterilizing at 80 DEG C-120 DEG C, is more preferably, sterilizing at 100 DEG C).

According to preparation method recited above, preferred scheme is: step (5) charcoal treatment (preferably, the charcoal treatment with 0.2%) of 0.1%-0.3%.

Using method: intramuscular injection, each 2-4ml, every day 1 time; The each 10-20ml of intravenous drip, instils 1 time for every two days, 15 days courses for the treatment of.

The preparation method of described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia capsule, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct and (preferably, decoct 43-47 minute in 40-50 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction (preferably, decocts 33-37 minute in 30-40 minute, be more preferably, decoct 35 minutes), merging filtrate, is concentrated into 1/2 of original volume;

(4) Radix Bupleuri, Radix Scutellariae and Radix Codonopsis are cut into slices, the ethanol adding the 20%-30% of 6-10 times amount makees solvent, dipping, percolation, collect percolate, leave standstill 3-5 hour (preferred, leave standstill 3.5-4.5 hour, be more preferably, leave standstill 4 hours), filter, filtrate recycling ethanol is extremely without alcohol taste;

(5) step (3)-(4) gained liquid mixing is even, be concentrated into relative density 1.10-1.20(preferred, be concentrated into relative density 1.12-1.18, be more preferably, be concentrated into relative density 1.15), mixing, dries, and pulverizes, obtains medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 2-3 grain, every day 1 time, 15 days courses for the treatment of.

The preparation method of described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct and (preferably, decoct 43-47 minute in 40-50 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction (preferably, decocts 33-37 minute in 30-40 minute, be more preferably, decoct 35 minutes), merging filtrate, is concentrated into 1/2 of original volume;

(4) Radix Bupleuri, Radix Scutellariae and Radix Codonopsis are cut into slices, the ethanol adding the 20%-30% of 6-10 times amount makees solvent, dipping, percolation, collect percolate, leave standstill 3-5 hour (preferred, leave standstill 3.5-4.5 hour, be more preferably, leave standstill 4 hours), filter, filtrate recycling ethanol is extremely without alcohol taste;

(5) by even for step (3)-(4) gained liquid mixing, be concentrated into relative density 1.10-1.20(preferred, be concentrated into relative density 1.12-1.18, be more preferably, be concentrated into relative density 1.15), make the namely loose soft material that hands pinches agglomerating pressure, with fashion of extrusion by 18-26 eye mesh screen, make uniform granule, dry, be pressed into lamellar, sugar coating.

According to preparation method recited above, preferred scheme is: step (5) by 20-24 eye mesh screen, preferably, passes through 22 eye mesh screens with fashion of extrusion with fashion of extrusion.

Instructions of taking: each 1-2 sheet, every day 1 time, 15 days courses for the treatment of.

Beneficial effect of the present invention is mainly reflected in:

1, the present invention is used for the treatment of hypertension, has QI invigorating nourishing kidney, nourishing the liver and kidney, and effect of tranquilizing by nourishing the heart is suitable for various hypertension, is especially applicable to hypertension I phase.

2, can effect a radical cure hypertension, patient does not need to take medicine all the life, and this both decreased misery to patient, again saved spending.

3, be a great breakthrough, solve the insurmountable problem of doctor trained in Western medicine.

4, avoid the defect that the side effect of oral western medicine is large, overcome simultaneously and easily form dependent deficiency to Western medicine, the present invention has no side effect, safe and effective.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

The pharmacological effect of each crude drug is respectively:

Radix Bupleuri: bitter in the mouth, cold nature.Return liver, gallbladder meridian.For the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..There is reconciling superficies and interior, soothing the liver, effect of yang invigorating.For cold, fever. alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.

Herba Lycopi: bitter in the mouth, pungent, slightly warm in nature.Return liver, spleen channel.For the dry aerial parts of labiate hair leaf lycopus lucidus.There is blood circulation promoting and blood stasis dispelling, effect of line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.

Radix Cynanchi Paniculati: acrid in the mouth, warm in nature.Return liver, stomach warp.For the dry root and rhizome of asclepiadaceae plant Radix Cynanchi Paniculati.There is removing dampness of dispeling the wind, effect of antalgesic-antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.

Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.For the dry root of labiate Radix Scutellariae.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.For vomiting uncomfortable in chest, dysentery, jaundice, cough due to lung-heat, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Codonopsis: sweet in the mouth, property is put down.Return spleen, lung meridian.For Campanulaceae Radix Codonopsis, the plain dry root spending Radix Codonopsis or radix codonpsis tangshen.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Poria: sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.Being commonly called as Poria, Song Ling, Poria, is the dry sclerotia of On Polyporaceae Poria.There is promoting diuresis to eliminate damp pathogen, effect of spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Os Draconis: sweet in the mouth, puckery, property is put down.Enter the heart, liver, kidney channel.For ancient times mammal as if the fossil of skeleton of class, rhinoceros class, Hippocampal cortex etc.Main containing calcium carbonate (CaCO ₃), calcium phosphate (Ca ₃(PO ₄) ₂), Shao Liangtie, magnesium, aluminum, potassium, sodium, chlorine, sulfate radical etc.The product of giving birth to have effect of subduing hyperactive YANG to ease mental disorders, and for hyperactivity of YANG due to deficiency of YIN, irritable, palpitation and insomnia, has a dizzy spell, demented frightened disease such as grade.Forging rear merit restrains astringent or styptic treatment for spontaneous sweating partially, and be used for premature ejaculation of passing out semen, leukorrhagia metrorrhagia, sweating due to debility chronic diarrhea, eczema prurigo, the open sore part is not held back, traumatic hemorrhage etc.In addition, forge and grind external, energy removing dampness sore, controls again eczema flowing water, with the passing of time unhealed.

Cornu Caprae seu Ovis: salty in the mouth, cool in nature.Return liver, heart channel.For the angle of bovid male goat or male sheep.There is heat clearing away, relieving convulsion, improving eyesight, effect of removing toxic substances.For pediatric epilepsy scared, headache due to pathogenic wind-heat, unhappy, spit blood, optic atrohic blindness, toxic swelling.

Concha Ostreae: salty in the mouth, cold nature.Return liver, gallbladder, kidney channel.For the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating effect.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Fructus Phyllanthi: sweet in the mouth, acid, puckery, cool in nature.Attach to the lung and stomach meridians.For the dry mature fruit of euphorbia plant Fructus Phyllanthi.There is clearing away heat and cooling blood, promoting digestion and invigorating the stomach, the effect of cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, dyspepsia, abdominal distention, cough, laryngalgia, xerostomia.

Radix et Rhizoma Rhei (stir-fried with wine): bitter in the mouth, cold in nature.Return stomach, spleen, large intestine, liver, pericardium channel.For the processed product of rhubarb medicinal material.And Radix Et Rhizoma Rhei is polygonum rheum palmatum, the dry root and rhizome of Rheum tanguticum or Rheum officinale.Total amount containing aloe-emodin, chrysophanic acid, emodin, chrysophanol, physcione must not be less than 1.0%.There is effect of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, stagnate for Gastrointestinal excess heat, constipation, abdominal part distension, pain with tenderness, hyperpyrexia, unconsciousness and delirium, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury.

Haematitum: bitter but sweet flavor, property is put down.Enter liver, stomach, heart born of the same parents warp.There is suppressing the hyperactive liver town inverse, effect of cooling blood for hemostasis.For eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spits blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.

embodiment 1hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, takes off and states primary raw material and be prepared from (getting 50g for every part): Radix Bupleuri 10 parts; Herba Lycopi 9 parts; Radix Cynanchi Paniculati 6 parts; Radix Scutellariae 8 parts; Radix Codonopsis 9 parts; 6 parts, Poria; Os Draconis 5 parts; Cornu Caprae seu Ovis 9 parts; Concha Ostreae 5 parts; Fructus Phyllanthi 7 parts; Radix et Rhizoma Rhei (stir-fried with wine) 5 parts; Haematitum 9 parts.

The preparation method of above-mentioned hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia decoction, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct 45 minutes, add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction 35 minutes, merging filtrate, is concentrated into 1/2 of original volume;

(4) by the section of Radix Bupleuri, Radix Scutellariae and Radix Codonopsis, the ethanol adding 25% of 8 times amount makees solvent, dipping, and percolation collects percolate, leaves standstill 4 hours, filters, and filtrate recycling ethanol is extremely without alcohol taste;

(5) step (3)-(4) gained liquid mixing is even, add be equivalent to mixed liquor quality 8% correctives sucrose, sterile packaged.

Instructions of taking: each 8-10ml, every day 3 times, 15 days courses for the treatment of.

model case one:dong XX, female, 49 years old, Jining City in Shandong Province Qufu City people.Suffer from hypertension (constitutional) and have 22 days so far.Originally do not take notice of time, until diastolic pressure reaches 100 millimetress of mercury just now with regard to medical drugs, examine as hypertension I phase.Take FUFANG JIANGYA PIAN 1 at the beginning every day and just steadily can control blood pressure, the dosage of 1 every day complete uncontrollable blood pressure after several years, so dosage is taken medicine voluntarily, but blood pressure is fluctuated by normally transferring to, consulting specialist, the doctor told Mrs Dong is to falling sheet drug resistance again.

Seeked advice from the traditional Chinese medical science afterwards, so start to take embodiment 1 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia decoction, within originally several days, antihypertensive effect is not obvious, and within one week, curative effect is seen at rear, but does not also drop to normal value.After having taken 2 courses for the treatment of, blood pressure has remained in safety range always, and period in a medicine there is no discomfort.Just start to attempt minimizing dosage, effect is comparatively obvious, and controlling of blood pressure is about 120/80 millimetres of mercury.Visit after half a year and learn recovery from illness.

embodiment 2hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, takes off and states primary raw material and be prepared from (getting 60g for every part): Radix Bupleuri 13 parts; Herba Lycopi 10 parts; Radix Cynanchi Paniculati 7 parts; Radix Scutellariae 10 parts; Radix Codonopsis 10 parts; 7 parts, Poria; Os Draconis 6 parts; Cornu Caprae seu Ovis 11 parts; Concha Ostreae 6 parts; Fructus Phyllanthi 8 parts; Radix et Rhizoma Rhei (stir-fried with wine) 6 parts; Haematitum 11 parts.

The preparation method of above-mentioned hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia injection, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct 45 minutes, add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction 35 minutes, merging filtrate, be condensed into the thick paste that relative density is 1.25, dry, be ground into fine powder;

(4) Radix Bupleuri, Radix Scutellariae and Radix Codonopsis are cut into slices, water extraction twice, boils 55 minutes at every turn, twice filtrate merges, and adds the ethanol of 5 times 25%, fully stirs, put on cloth funnel and be separated, discard ethanol mother liquor, add the solution lead acetate of be equivalent to crude drug amount 5% being made into 20%, fully stir, precipitation separation, drip sodium carbonate, regulate pH to 6.5, dry;

(5) get step (3)-(4) gains, add water for injection by recipe quantity and dissolve, adjust pH to 6.5, once, suction strainer, adds to the full amount of water for injection charcoal treatment with 0.2%, use glass funnel fine straining, be sub-packed in 2 milliliters or 10 milliliters of ampoules, sterilizing 30 minutes at 100 DEG C.

Using method: intramuscular injection, each 2-4ml, every day 1 time; The each 10-20ml of intravenous drip, instils 1 time for every two days, 15 days courses for the treatment of.

model case two:du XX, man, 58 years old, Rizhao City, Shandong Province from Wulian County.Before 3 years, there is dizziness headache without under obvious inducement, certainly take analgesic without improvement, paroxysmal headaches, with dizziness, irritable, soreness of the waist and knees, xerostomia.Blood pressure high pressure 140 millimeters of high mercury column at ordinary times, low pressure 100 millimeters of high mercury column.Find after suffering from hypertension and take hypertension pill always, drug withdrawal after normal, but the rising that just rebounds immediately after drug withdrawal.Usually there is severe headache, irritated, dizzy, nausea and vomiting, the symptom such as uncomfortable in chest.

Instillation embodiment 2 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia injection, after 1 course for the treatment of, dizziness headache, irritable and soreness of the waist and knees obviously alleviate, blood pressure drops.After continuing 2 courses for the treatment of of instillation, hypertensive symptom is eased completely, controlling of blood pressure about 110/80 millimetres of mercury, drug withdrawal after one month Measure blood pressure still without rising, recover.

embodiment 3hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, takes off and states primary raw material and be prepared from (getting 40g for every part): Radix Bupleuri 17 parts; Herba Lycopi 11 parts; Radix Cynanchi Paniculati 9 parts; Radix Scutellariae 13 parts; Radix Codonopsis 11 parts; 9 parts, Poria; Os Draconis 8 parts; Cornu Caprae seu Ovis 13 parts; Concha Ostreae 8 parts; Fructus Phyllanthi 11 parts; Radix et Rhizoma Rhei (stir-fried with wine) 9 parts; Haematitum 13 parts.

The preparation method of above-mentioned hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia capsule, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct 45 minutes, add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction 35 minutes, merging filtrate, is concentrated into 1/2 of original volume;

(4) by the section of Radix Bupleuri, Radix Scutellariae and Radix Codonopsis, the ethanol adding 25% of 8 times amount makees solvent, dipping, and percolation collects percolate, leaves standstill 4 hours, filters, and filtrate recycling ethanol is extremely without alcohol taste;

(5) step (3)-(4) gained liquid mixing is even, be concentrated into relative density 1.15, mixing, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 2-3 grain, every day 1 time, 15 days courses for the treatment of.

model case three:wu XX, man, 49 years old, people from Qihe County, Dezhou City Shandong Province.Suffer from hypertension and have more than 10 year, take antihypertensive drugs at ordinary times irregular, often forget and take medicine, conscious dizziness, headache just do not take antihypertensive drugs in good time, and little Measure blood pressure situation.Recently because housework is tired, the significant headache of early morning WA appearance, dizziness, take compound recipe reserpine at home certainly, dizzy slightly improvement.Again dizziness is there is, flushed complexion after one week, irritated, the symptoms such as two knees soreness.

Take measuring blood pressure 120/90mmHg after 1 course for the treatment of of embodiment 3 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia capsule, still occasionally have dizziness, headache and irritatedly softly obviously to alleviate, after movable, slightly the two lower limb of sense are aching and limp, measuring blood pressure 140/90mmHg.After adhering to again taking 1 course for the treatment of, transference cure, blood pressure stabilization.Drug withdrawal after 3 months Measure blood pressure still without rising, recover.

embodiment 4hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, takes off and states primary raw material and be prepared from (getting 20g for every part): Radix Bupleuri 15 parts; Herba Lycopi 10.5 parts; Radix Cynanchi Paniculati 8 parts; Radix Scutellariae 11 parts; Radix Codonopsis 10.5 parts; 8 parts, Poria; Os Draconis 7 parts; Cornu Caprae seu Ovis 12 parts; Concha Ostreae 7 parts; Fructus Phyllanthi 9 parts; Radix et Rhizoma Rhei (stir-fried with wine) 7 parts; Haematitum 12 parts.

The preparation method of above-mentioned hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet, step is as follows:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct 45 minutes, add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction 35 minutes, merging filtrate, is concentrated into 1/2 of original volume;

(4) by the section of Radix Bupleuri, Radix Scutellariae and Radix Codonopsis, the ethanol adding 25% of 8 times amount makees solvent, dipping, and percolation collects percolate, leaves standstill 4 hours, filters, and filtrate recycling ethanol is extremely without alcohol taste;

(5) step (3)-(4) gained liquid mixing is even, be concentrated into relative density 1.15, make the namely loose soft material that hands pinches agglomerating pressure, with fashion of extrusion by 22 eye mesh screens, make uniform granule, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 1-2 sheet, every day 1 time, 15 days courses for the treatment of.

test example:for the examination of curative effect of embodiment 4 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet, we have done toxicity test and clinical trial, and concrete condition is as follows:

toxicity test acute toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.Need the feeding room to mice, cage tool, drinking bottle etc. to carry out disinfection before raising, before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, ensure female not producing, without pregnant.Gastric perfusion needle is used to carry out gavage to mice: to be melted by embodiment 4 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet warm water, gastric perfusion needle is inserted by animal bicker, general depth of needle 2.5-3cm, every mouse stomach 0.3ml medicinal liquid, the reaction of close observation mice after administration, observes 15 days, and experimental animal does not find poisoning manifestations, without dead, dissect obviously not abnormal, judge that hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia of the present invention is to the nontoxic level in the true border of Mouse Acute Toxicity.

long term toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.The feeding room to mice, cage tool, drinking bottle etc. is needed to carry out disinfection before raising.Before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, same guarantee is female does not produce, without pregnant.Take embodiment 4 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet warm water to melt, every mice controls dosage 1g every day, continuous use 7 weeks, drug withdrawal was observed after 3 weeks, weighs weekly once, can be observed amount of drinking water appetite all normal during administration, body weight increases, without dead or moribund animals, the index such as hair, behavior, defecation, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of mice all has no significant effect, and internal organs naked eyes do not find difference change.Histological indications shows, medication 7 weeks and drug withdrawal are after 3 weeks, and Organs of Mice all without obviously changing, illustrates that hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia of the present invention is very little to toxicity after mice long-term prescription, does not also have difference reaction, application safety after drug withdrawal.

clinical trial:in order to verify the curative effect of the hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet of embodiment 4 gained, We conducted contrast test.Experiment sieving early high blood pressure patient 250 people, screening criteria: systolic pressure is equal to or higher than 140mmHg, diastolic pressure is equal to or higher than 90mmHg, both have one to examine namely to belong to hypertension (to get rid of the age below 18 one full year of life or more than 70 one full year of life; Trimester of pregnancy or women breast-feeding their children; Be associated with the severe primary diseases such as liver, kidney and hemopoietic system; Psychotic etc.).In the object making a definite diagnosis observation, male 128 example, women 122 example, 57.6 years old mean age.Be divided into matched group and experimental group randomly, wherein experimental group has 150 people, and matched group has 100 people.Experimental group: take embodiment 4 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet, each 1-2 sheet, every day 1 time, 15 days courses for the treatment of; Matched group: adopt other treatment scheme, the medicines such as handkerchief amine (indapamide), verapamil hydrochloride tablets, nitrendipine of such as rattling away.Our every days same equal time, medication under square one, and the health of observing simultaneously, recording every group patient.With reference to the therapeutic goal of the Chinese hypertension prevention and control guide of Chinese hypertension alliance in 1999 revision, curative effect situation criterion: cure: diastolic pressure more than decline 10mmHg, and reach normal range, though or diastolic pressure do not reach the normal range of decline 20mmHg or more; Effective: diastolic pressure declines not as good as 10mmHg, reaches normal range, though or diastolic pressure do not reach normal range but the 10-19mmHg that declined, or systolic pressure more than decline 30mmHg; Invalid: systolic pressure and diastolic pressure do not reach above-mentioned standard.Wherein effectively comprise recovery from illness and effective.The Comparison of therapeutic of matched group and experimental group, concrete condition is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, the curative effect of the embodiment of the present invention 4 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet is taken more than the good effect using other treatment mode.Wherein, from effective percentage, take embodiment 4 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet up to 97.33%, and use other treatment mode be only 86%; From cure rate, take the cure rate of embodiment 4 gained hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet up to 66%, and use other treatment mode (such as taking the medicines such as handkerchief amine [indapamide], verapamil hydrochloride tablets, nitrendipine of rattling away) be only 42%.Can draw the evident in efficacy of hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia tablet of the present invention, and cure rate is high, inefficiency is low.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Bupleuri 10-20 part; Herba Lycopi 9-12 part; Radix Cynanchi Paniculati 6-10 part; Radix Scutellariae 8-15 part; Radix Codonopsis 9-12 part; Poria 6-10 part; Os Draconis 5-9 part; Cornu Caprae seu Ovis 9-15 part; Concha Ostreae 5-9 part; Fructus Phyllanthi 7-12 part; Radix et Rhizoma Rhei (stir-fried with wine) 5-10 part; Haematitum 9-15 part.

2. hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia according to claim 1, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Bupleuri 13-17 part; Herba Lycopi 10-11 part; Radix Cynanchi Paniculati 7-9 part; Radix Scutellariae 10-13 part; Radix Codonopsis 10-11 part; Poria 7-9 part; Os Draconis 6-8 part; Cornu Caprae seu Ovis 11-13 part; Concha Ostreae 6-8 part; Fructus Phyllanthi 8-11 part; Radix et Rhizoma Rhei (stir-fried with wine) 6-9 part; Haematitum 11-13 part.

3. hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia according to claim 1, is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Bupleuri 15 parts; Herba Lycopi 10.5 parts; Radix Cynanchi Paniculati 8 parts; Radix Scutellariae 11 parts; Radix Codonopsis 10.5 parts; 8 parts, Poria; Os Draconis 7 parts; Cornu Caprae seu Ovis 12 parts; Concha Ostreae 7 parts; Fructus Phyllanthi 9 parts; Radix et Rhizoma Rhei (stir-fried with wine) 7 parts; Haematitum 12 parts.

4., according to the arbitrary described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia of claim 1-3, it is characterized in that, this hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia is made pharmaceutically acceptable decoction, and preparation method is:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct and (preferably, decoct 43-47 minute in 40-50 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction (preferably, decocts 33-37 minute in 30-40 minute, be more preferably, decoct 35 minutes), merging filtrate, is concentrated into 1/2 of original volume;

(4) Radix Bupleuri, Radix Scutellariae and Radix Codonopsis are cut into slices, the ethanol adding the 20%-30% of 6-10 times amount makees solvent, dipping, percolation, collect percolate, leave standstill 3-5 hour (preferred, leave standstill 3.5-4.5 hour, be more preferably, leave standstill 4 hours), filter, filtrate recycling ethanol is extremely without alcohol taste;

(5) by even for step (3)-(4) gained liquid mixing, the correctives sucrose adding the 5%-10% being equivalent to mixed liquor quality is (preferred, add the correctives sucrose of the 6%-9% being equivalent to mixed liquor quality, be more preferably, add be equivalent to mixed liquor quality 8% correctives sucrose), sterile packaged.

5. the preparation method of hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia according to claim 4, is characterized in that: the ethanol that step (4) adds the 23%-27% of 7-9 times amount makees solvent (preferred, the ethanol adding 25% of 8 times amount makees solvent).

6., according to the arbitrary described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia of claim 1-3, it is characterized in that, this hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia is made pharmaceutically acceptable injection, and preparation method is:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) by Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct 40-50 minute (preferably, decoct 43-47 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction 30-40 minute is (preferred, decoct 33-37 minute, be more preferably, decoct 35 minutes), merging filtrate, being condensed into relative density is 1.20-1.30(45 DEG C) thick paste (preferred, be condensed into the thick paste that relative density is 1.23-1.27, be more preferably, be condensed into the thick paste that relative density is 1.25), dry, be ground into fine powder,

(4) by Radix Bupleuri, Radix Scutellariae and Radix Codonopsis section, water extraction twice, boil 50-60 minute (preferably at every turn, boil 53-57 minute at every turn, be more preferably, boil 55 minutes) at every turn, twice filtrate merges, add the ethanol of 3-7 20%-30% doubly, abundant stirring, put on cloth funnel and be separated, discard ethanol mother liquor, add lead acetate (preferred, be equivalent to the lead acetate of the 4%-6% of crude drug amount, add after being made into the solution of 15%-25%, be more preferably, be equivalent to the lead acetate of 5% of crude drug amount, add after being made into the solution of 20%), abundant stirring, precipitation separation, drip sodium carbonate, regulate pH to 6.0-7.0(preferred, regulate pH to 6.3-6.7, be more preferably, regulate pH to 6.5), dry,

(5) step (3)-(4) gains are got, by recipe quantity add water for injection dissolve, adjust pH to 6.5, with charcoal treatment once, suction strainer, add to the full amount of water for injection, use glass funnel fine straining, be sub-packed in 2 milliliters or 10 milliliters of ampoules, sterilizing 30 minutes is (preferred, sterilizing at 80 DEG C-120 DEG C, is more preferably, sterilizing at 100 DEG C).

7. the preparation method of hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia according to claim 6, is characterized in that: step (5) charcoal treatment (preferably, the charcoal treatment with 0.2%) of 0.1%-0.3%.

8., according to the arbitrary described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia of claim 1-3, it is characterized in that, this hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia is made pharmaceutically acceptable capsule, and preparation method is:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct and (preferably, decoct 43-47 minute in 40-50 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction (preferably, decocts 33-37 minute in 30-40 minute, be more preferably, decoct 35 minutes), merging filtrate, is concentrated into 1/2 of original volume;

(4) Radix Bupleuri, Radix Scutellariae and Radix Codonopsis are cut into slices, the ethanol adding the 20%-30% of 6-10 times amount makees solvent, dipping, percolation, collect percolate, leave standstill 3-5 hour (preferred, leave standstill 3.5-4.5 hour, be more preferably, leave standstill 4 hours), filter, filtrate recycling ethanol is extremely without alcohol taste;

(5) step (3)-(4) gained liquid mixing is even, be concentrated into relative density 1.10-1.20(preferred, be concentrated into relative density 1.12-1.18, be more preferably, be concentrated into relative density 1.15), mixing, dries, and pulverizes, obtains medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

9., according to the arbitrary described hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia of claim 1-3, it is characterized in that, this hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia is made pharmaceutically acceptable tablet, and preparation method is:

(1) cut into slices by Radix Cynanchi Paniculati, mix thoroughly with vinegar, vexed to profit, slow fire is fried to micro-yellow;

(2) smashed by Haematitum, be placed in crucible, smokeless stove fire is calcined to and is popular in, take out, shortcake of quenching in impouring vinegar basin immediately, smashs to pieces, dries, be ground into coarser powder;

(3) Poria, Os Draconis, Cornu Caprae seu Ovis and Concha Ostreae are smashed, be placed in glass container, soak 2 days, pour in marmite, decoct and (preferably, decoct 43-47 minute in 40-50 minute, be more preferably, decoct 45 minutes), add step (1)-(2) gains, Herba Lycopi, Fructus Phyllanthi and Radix et Rhizoma Rhei (stir-fried with wine), continue decoction twice, each decoction (preferably, decocts 33-37 minute in 30-40 minute, be more preferably, decoct 35 minutes), merging filtrate, is concentrated into 1/2 of original volume;

(4) Radix Bupleuri, Radix Scutellariae and Radix Codonopsis are cut into slices, the ethanol adding the 20%-30% of 6-10 times amount makees solvent, dipping, percolation, collect percolate, leave standstill 3-5 hour (preferred, leave standstill 3.5-4.5 hour, be more preferably, leave standstill 4 hours), filter, filtrate recycling ethanol is extremely without alcohol taste;

(5) by even for step (3)-(4) gained liquid mixing, be concentrated into relative density 1.10-1.20(preferred, be concentrated into relative density 1.12-1.18, be more preferably, be concentrated into relative density 1.15), make the namely loose soft material that hands pinches agglomerating pressure, with fashion of extrusion by 18-26 eye mesh screen, make uniform granule, dry, be pressed into lamellar, sugar coating.

10. the preparation method of hypertension I phase tranquillizing and allaying excitement Chinese drugs agentia according to claim 9, is characterized in that: step (5) by 20-24 eye mesh screen, preferably, passes through 22 eye mesh screens with fashion of extrusion with fashion of extrusion.