CN105288066A - Prescription for treating atherosclerosis and preparation method thereof - Google Patents
Prescription for treating atherosclerosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a prescription for treating atherosclerosis and a preparation method thereof. The prescription is mainly prepared from, by mass, 6-11 parts of rhizoma alismatis, 8-12 parts of mesona blumes, 5-13 parts of geranium strictipes, 8-14 parts of Japan clover herb, 6-10 parts of jasmine flowers, 7-12 parts of polygonum cuspidatum, 9-13 parts of andrographis paniculata, 8-12 parts of atractylodes macrocephala koidz, 6-13 parts of day lily, 4-10 parts of biondia henryi, 7-13 parts of suberect spatholobus stems, 9-14 parts of ficus formosana roots, 6-12 parts of lance asiabell roots, 8-13 parts of syneilesis aconitifolia and 4-11 parts of flemingia philippinensis. According to the prescription, by regulating blood fat, damage of lipid to endothelial cells is reduced, and accumulation of lipid is reduced to a certain extent; meanwhile, the blood mobility is improved, all unwell symptoms caused by atherosclerosis are relieved, and therefore the effect of resisting atherosclerosis is achieved.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly one treats atherosclerotic prescription and preparation method.
Background technology
Atherosclerosis is most important one common in one group of arteriosclerotic angiopathy, is characterized in getting involved arterial disease from inner membrance.General first have that lipid and compound saccharide gather, hemorrhage and thrombosis, proliferation of fibrous tissue and calcinosis, and having medial transformation gradually and calcification; pathological changes often involves elasticity and large medium muscular artery; be enough to obstructing arterial chamber once develop into, then the tissue supplied of this tremulous pulse or organ are by ischemia or necrosis.Because the lipid outward appearance gathered at endarterium is yellow medicated porridge sample, be therefore called atherosclerosis.Atherosclerosis is exactly arterial wall deposited the lipid of one deck as milled congee sample, makes the pathological changes that arterial elasticity lowers, tube chamber narrows.Hypertension promotes that atherosclerosis occurs, the important factor of development, and tremulous pulse caused narrowly causes secondary hypertension because of atherosis.Therefore interact therebetween, promote mutually, on very close terms.Hypertension promotes atherosclerosis, is multiplely born in large, medium-sized artery, comprises these fortress passages such as the coronary artery of heart, the cerebral arteries of head.Hypertension causes blood to impact tunica intima, causes tube wall thickening, tube chamber attenuates.Tube wall inner membrance impaired rear be easily cholesterol, lipidosis, increased the weight of the formation of atherosclerotic plaque.Therefore, hypertension is atherosclerotic risk factor.
Atherosclerosis is arteriosclerotic one, and the yellow substance containing cholesterol, class fat etc. appears in large, medium-sized artery inner membrance, and how by fat metabolic disturbance, neural blood vessel functional disorder causes.Often cause thrombosis, blood supply disorder etc.Atherosclerotic symptom depends mainly on the degree of ischemia of vascular lesion and afflicted organ, atherosclerosis of aorta is often asymptomatic, coronary atherosclerosis person, if caliber is narrow reach more than 75%, then can there is angina pectoris, myocardial infarction, arrhythmia, even die suddenly.Cerebral arteriosclerosis can cause cerebral ischemia, brain atrophy, or causes rupture of blood vessel in brain hemorrhage, and atherosclerotic renal artery stenosis often causes nocturia, intractable hypertension, severe patient to have renal insufficiency.After superior mesenteric atherosclerosis can show as heavy meal, stomachache such as to be had blood in stool at the symptom.Lower limb atherosclerosis causes lumen of vessels Serious Stenosis person can occur intermittent claudication, pulsation of foot dorsal artery disappearance, and severe patient even gangrene can occur.
At present, treat in atherosclerotic medicine, publication number CN104887844A(application number 201510281712.X) patent document discloses a kind of antiatherogenic pharmaceutical composition and application thereof, described pharmaceutical composition is prepared from through water boiling and extraction by the Chinese crude drug of following mass parts: Folium Mori 10-18 part, Herba Solidaginis 20-33 part, Folium Momordicae Charantiae 16-23 part, Flos Sophorae 30-39 part, Fructus Viticis 10-18 part, Radix Aucklandiae 3-7 part, Sargassum 10-18 part, Flos Magnoliae 10-18 part, Spica Prunellae 16-23 part, Auricularia 20-33 part.Publication number CN102716428A(application number 201210230210.0) patent document discloses a kind of antiatherogenic Chinese medicine composition, this Chinese medicine composition is made up of the crude drug of following weight portion: Ramulus Euonymi 20-30 part, Herba Dendrobii 15-25 part, Radix Polygoni Multiflori Preparata 10-20 part, Rhizoma Alismatis 10-20 part, Semen Cassiae (parched) 10-20 part, RADIX CURCUMAE 5-15 part.Publication number CN103977204A(application number 201410242585.8) patent document discloses the atherosclerotic Chinese medicine of a kind of control, comprise Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Herba Asari, Rhizoma Cyperi, Herba Menthae, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Flos Chrysanthemi, Radix Paeoniae Rubra, Rhizoma Corydalis and Radix Gentianae, wherein the ratio of weight and number of each component is: Rhizoma Chuanxiong 12-18 part, Herba Schizonepetae 8-12 part, Radix Saposhnikoviae 8-12 part, Herba Asari 2-4 part, Rhizoma Cyperi 8-12 part, Herba Menthae 8-12 part, Rhizoma Et Radix Notopterygii 8-12 part, Radix Angelicae Dahuricae 8-12 part, Flos Chrysanthemi 12-18 part, Radix Paeoniae Rubra 12-18 part, Rhizoma Corydalis 7-13 part, Radix Gentianae 10-15 part.
Doctor trained in Western medicine mostly is at present for atherosclerotic treatment, blood lipid-lowering medicine and antiplatelet drug is mainly taked to alleviate, these medicine general actions are rapid, and taking a moment just can symptom management, but majority is cured the symptoms, not the disease, often just need take all the life once take, drug withdrawal often causes the bounce-back of disease, and life-time service normally runs affecting body, and causes huge injury to liver, renal function, life-time service will inevitably cause the disease of liver, kidney aspect, and side effect is large.There is therapeutic effect not significantly outstanding problem in the atherosclerotic Chinese medicine of existing treatment, rarely has the Chinese medicine of determined curative effect.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide the atherosclerotic prescription for the treatment of, pass through adjusting blood lipid, reduce the damage of lipid Human Umbilical Vein Endothelial Cells, reduce the accumulation of lipid to a certain extent, increase blood fluidity simultaneously, alleviate the various malaise symptoms that atherosclerosis causes, thus play ideal study of anti-atherogenic effect.Another object of the present invention is just to provide the preparation method of the atherosclerotic prescription of above-mentioned treatment.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat atherosclerotic prescription, take off the primary raw material stating quality proportioning and be prepared from: Rhizoma Alismatis 6-11 part; Herba mesonae chinensis 8-12 part; Radix cynanchi wilfordii 5-13 part; Herba Kummerowiae Striatae 8-14 part; Flos Jasmini Sambac 6-10 part; Rhizoma Polygoni Cuspidati 7-12 part; Herba Andrographis 9-13 part; Rhizoma Atractylodis Macrocephalae 8-12 part; Flos Hemerocallis 6-13 part; Herba Biondiae henryi 4-10 part; Caulis Spatholobi 7-13 part; Radix Fici beecheyanae 9-14 part; Radix Codonopsis lanceolatae 6-12 part; Herba Syneilesis Aconitifoliae 8-13 part; Radix Flemingiae Philippinensis 4-11 part.
Treat atherosclerotic prescription, preferred scheme is, takes off the primary raw material stating quality proportioning and is prepared from: Rhizoma Alismatis 8-10 part; Herba mesonae chinensis 9-11 part; Radix cynanchi wilfordii 8-10 part; Herba Kummerowiae Striatae 10-12 part; Flos Jasmini Sambac 7-9 part; Rhizoma Polygoni Cuspidati 9-11 part; Herba Andrographis 10-12 part; Rhizoma Atractylodis Macrocephalae 9-11 part; Flos Hemerocallis 9-11 part; Herba Biondiae henryi 6-8 part; Caulis Spatholobi 9-11 part; Radix Fici beecheyanae 11-13 part; Radix Codonopsis lanceolatae 8-10 part; Herba Syneilesis Aconitifoliae 10-12 part; Radix Flemingiae Philippinensis 7-9 part.
Treat atherosclerotic prescription, the scheme be more preferably is, takes off the primary raw material stating quality proportioning and is prepared from
:rhizoma Alismatis 9 parts; Herba mesonae chinensis 10 parts; Radix cynanchi wilfordii 9 parts; Herba Kummerowiae Striatae 11 parts; Flos Jasmini Sambac 8 parts; Rhizoma Polygoni Cuspidati 10 parts; Herba Andrographis 11 parts; The Rhizoma Atractylodis Macrocephalae 10 parts; Flos Hemerocallis 10 parts; Herba Biondiae henryi 7 parts; Caulis Spatholobi 10 parts; Radix Fici beecheyanae 12 parts; Radix Codonopsis lanceolatae 9 parts; Herba Syneilesis Aconitifoliae 11 parts; Radix Flemingiae Philippinensis 8 parts.
Present invention also offers the preparation method atherosclerotic for above-mentioned treatment prescription being made pharmaceutically acceptable powder, decoction, pill, tablet and granule.
The preparation method of the atherosclerotic prescription powder of described treatment, step is as follows:
(1) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry, pulverize, cross 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);
(2) Herba mesonae chinensis, Herba Kummerowiae Striatae, Flos Jasmini Sambac, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) humus flava usta is placed in frying pan, moderate heat stirs 10-15 minute, add Radix cynanchi wilfordii, Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae, Radix Codonopsis lanceolatae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, sieve removes humus flava usta, porphyrize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae gross mass 3-5 doubly, the consumption being more preferably rice wine be Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(5) by step (1)-(4) gained medicated powder mix homogeneously, sterile packaged.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 7 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of the atherosclerotic prescription decoction of described treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine of 30o-40o, moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, filters, sterile packaged.
The preparation method of the atherosclerotic prescription decoction of above-mentioned treatment, the consumption of the preferred rice wine of step (4) is 3-5 times of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass, and the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times.
Instructions of taking: each 50-80ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 7 days courses for the treatment of.
The preparation method of the atherosclerotic prescription pill of described treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass doubly, the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 10-15 ball, every day 3 times, 7 days courses for the treatment of.
The preparation method of the atherosclerotic prescription tablet of described treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass doubly, the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2, every day 3 times, 7 days courses for the treatment of.
The preparation method of the atherosclerotic prescription granule of described treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass doubly, the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, add simple syrup, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
The preparation method of the atherosclerotic prescription granule of above-mentioned treatment, the consumption of the preferred simple syrup of step (5) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
Instructions of taking: each 1 bag, every day 3 times, 7 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, prescription of the present invention passes through adjusting blood lipid, reduce the damage of lipid Human Umbilical Vein Endothelial Cells, reduce the accumulation of lipid to a certain extent, increase blood fluidity simultaneously, alleviate the various malaise symptoms that atherosclerosis causes, thus play antiatherogenic effect.
2, this formula belongs to Chinese medicine formula, compatibility rationally, select YAOJING good, can strengthen patient body body constitution, therapeutic effect is remarkable, and processing technology is simple, cheap.
3, prescription selected materials great majority of the present invention are Chinese medicine material, and not containing hormone, instant effect, cure rate are high, nothing recurs, has no side effect, and generally take medicine and just can take effect for 5-7 days.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat atherosclerotic prescription, take off the primary raw material stating weight proportion and be prepared from (getting 80g for every part): Rhizoma Alismatis 6 parts; Herba mesonae chinensis 8 parts; Radix cynanchi wilfordii 5 parts; Herba Kummerowiae Striatae 8 parts; Flos Jasmini Sambac 6 parts; Rhizoma Polygoni Cuspidati 7 parts; Herba Andrographis 9 parts; The Rhizoma Atractylodis Macrocephalae 8 parts; Flos Hemerocallis 6 parts; Herba Biondiae henryi 4 parts; Caulis Spatholobi 7 parts; Radix Fici beecheyanae 9 parts; Radix Codonopsis lanceolatae 6 parts; Herba Syneilesis Aconitifoliae 8 parts; Radix Flemingiae Philippinensis 4 parts.
The preparation method of the atherosclerotic prescription powder of above-mentioned treatment, step is as follows:
(1) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry, pulverize, cross 160 mesh sieves;
(2) Herba mesonae chinensis, Herba Kummerowiae Striatae, Flos Jasmini Sambac, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Radix cynanchi wilfordii, Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae, Radix Codonopsis lanceolatae and Radix Flemingiae Philippinensis, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta, porphyrize, crosses 160 mesh sieves;
(4) Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, add the rice wine (consumption be Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae gross mass 4 times) of 35o, moistening 4 days, takes out, dry, smash, cross 160 mesh sieves;
(5) by step (1)-(4) gained medicated powder mix homogeneously, sterile packaged.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 7 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2treat atherosclerotic prescription, take off the primary raw material stating weight proportion and be prepared from (every part of 20g): Rhizoma Alismatis 11 parts; Herba mesonae chinensis 12 parts; Radix cynanchi wilfordii 13 parts; Herba Kummerowiae Striatae 14 parts; Flos Jasmini Sambac 10 parts; Rhizoma Polygoni Cuspidati 12 parts; Herba Andrographis 13 parts; The Rhizoma Atractylodis Macrocephalae 12 parts; Flos Hemerocallis 13 parts; Herba Biondiae henryi 10 parts; Caulis Spatholobi 13 parts; Radix Fici beecheyanae 14 parts; Radix Codonopsis lanceolatae 12 parts; Herba Syneilesis Aconitifoliae 13 parts; Radix Flemingiae Philippinensis 11 parts.
The preparation method of the atherosclerotic prescription decoction of above-mentioned treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine of 35o, moistening 4 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, filters, sterile packaged.
Instructions of taking: each 70ml, every day 3 times, 7 days courses for the treatment of.
model case onewhat XX, man, 59 years old, people from Linyi.There is right lower extremity intermittent claudication without under obvious inducement in five or six Mr.s Nian Qianhe, so remove hospital admission, right lower extremity skin temperature obviously lowers, and right lower extremity is of flaccid muscles, and color-Doppler ultrasound shows: right popliteal artery Serious Stenosis, intra-arterial atherosclerosis plaque forming.Be diagnosed as right lower extremity atherosclerotic occlusive disease, be not improved after medication treatment one wheat harvesting period.After this once removed too much family hospital admission, most suggestion is performed the operation even amputation.The mental pressure of patient and household is very large.
Take after the present invention treats 2 courses for the treatment of of atherosclerotic prescription decoction (embodiment 2), check color-Doppler ultrasound shows: right femoral artery,superficial can be visited and strip blood flow.Check after continuing to take 2 courses for the treatment of blood flow velocity comparatively before higher and dorsal artery of foot blood flow is full can.The obviously increase of arteriopalmus skin temperature all can be touched after instep and shin.Later stage visits and learns and fully recover, and recovers better, not occur other malaise symptoms.
embodiment 3treat atherosclerotic prescription, take off the primary raw material stating weight proportion and be prepared from (getting 50g for every part): Rhizoma Alismatis 8 parts; Herba mesonae chinensis 9 parts; Radix cynanchi wilfordii 8 parts; Herba Kummerowiae Striatae 10 parts; Flos Jasmini Sambac 7 parts; Rhizoma Polygoni Cuspidati 9 parts; Herba Andrographis 10 parts; The Rhizoma Atractylodis Macrocephalae 9 parts; Flos Hemerocallis 9 parts; Herba Biondiae henryi 6 parts; Caulis Spatholobi 9 parts; Radix Fici beecheyanae 11 parts; Radix Codonopsis lanceolatae 8 parts; Herba Syneilesis Aconitifoliae 10 parts; Radix Flemingiae Philippinensis 7 parts.
The preparation method of the atherosclerotic prescription pill of above-mentioned treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine (consumption is 4 times of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass) of 35o, moistening 4 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.20(40 DEG C) thick paste, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 7 days courses for the treatment of.
embodiment 4treat atherosclerotic prescription, take off the primary raw material stating weight proportion and be prepared from (getting 35g for every part): Rhizoma Alismatis 10 parts; Herba mesonae chinensis 11 parts; Radix cynanchi wilfordii 10 parts; Herba Kummerowiae Striatae 12 parts; Flos Jasmini Sambac 9 parts; Rhizoma Polygoni Cuspidati 11 parts; Herba Andrographis 12 parts; The Rhizoma Atractylodis Macrocephalae 11 parts; Flos Hemerocallis 11 parts; Herba Biondiae henryi 8 parts; Caulis Spatholobi 11 parts; Radix Fici beecheyanae 13 parts; Radix Codonopsis lanceolatae 10 parts; Herba Syneilesis Aconitifoliae 12 parts; Radix Flemingiae Philippinensis 9 parts.
The preparation method of the atherosclerotic prescription tablet of above-mentioned treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine (consumption is 4 times of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass) of 35o, moistening 4 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.20(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 7 days courses for the treatment of.
model case twowu XX, man, 49 years old, people from Dezhou City Shandong Province.Without obvious inducement prominent sense precordialgia before Wu is first born in 3 or four years, pain is takeed on left and the radiation of left hand portion, and after a few minutes of having had a rest at that time, symptom is obviously alleviated, so also do not notice.But there is not again similar symptom in a few days, remove examination in hospital, be diagnosed as angina pectoris, to treat after one month symptom without obvious alleviation.After this often have similar symptom to occur, substantially all can occur that pareordia has an intense pain, after taking nitroglycerin, symptom is alleviated to some extent at every turn, but DeGrain.After the hospital that makes a return journey carefully check, last diagnostic is coronary atherosclerotic angina pectoris, and after hospitalization one wheat harvesting period, symptom is obviously alleviated, but soon occurs again similar symptom, fails to cure always.
Take after the present invention treats 2 courses for the treatment of of atherosclerotic prescription (embodiment 4), the diseases such as symptom obviously alleviates, and pain is obviously alleviated, sensation of oppression over the chest with shortness of breath disappear substantially.So after continuing to take 2 courses for the treatment of, all malaise symptoms disappear, and go to hospital to check display indices normal.Follow up a case by regular visits to middle state always better, also do not occur other malaise symptoms.
embodiment 5treat atherosclerotic prescription, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): Rhizoma Alismatis 9 parts; Herba mesonae chinensis 10 parts; Radix cynanchi wilfordii 9 parts; Herba Kummerowiae Striatae 11 parts; Flos Jasmini Sambac 8 parts; Rhizoma Polygoni Cuspidati 10 parts; Herba Andrographis 11 parts; The Rhizoma Atractylodis Macrocephalae 10 parts; Flos Hemerocallis 10 parts; Herba Biondiae henryi 7 parts; Caulis Spatholobi 10 parts; Radix Fici beecheyanae 12 parts; Radix Codonopsis lanceolatae 9 parts; Herba Syneilesis Aconitifoliae 11 parts; Radix Flemingiae Philippinensis 8 parts.
The preparation method of the atherosclerotic prescription granule of above-mentioned treatment, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine (consumption is 4 times of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass) of 35o, moistening 4 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being concentrated into relative density is 1.15(40 DEG C) thick paste, add simple syrup (consumption is 6% of thick paste quality), mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 7 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Alismatis: sweet in the mouth, bitterly disappointed.Return kidney, urinary bladder channel.For the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.There is diuresis, effect of clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.
Herba mesonae chinensis: sweet in the mouth, light, cold in nature.For the aerial parts of labiate Herba mesonae chinensis.Have and relieve summer heat, heat clearing away, removing heat from blood, effect of removing toxic substances.For middle person, diabetes, jaundice, has loose bowels, dysentery, hypertension, fat meat, arthralgia, acute nephritis, acute toothache, burn and scald, erysipelas, syphilis, and paint is irritated.
Radix cynanchi wilfordii: sweet in the mouth, micro-hardship, slightly warm in nature.Return liver,kidney,spleen warp.For the tuber of asclepiadaceae Cynanchum plant Radix cynanchi wilfordii.There is invigorating the liver and kidney, bone and muscle strengthening, effect of stomach invigorating.Empty for Liver and kidney two, feel dizzy, insomnia forgetfulness, early whitening of beard and hair, sexual impotence, seminal emission, soreness of the waist and knees, spleen insufficiency, distension and fullness in the abdomen, inappetence, has loose bowels, and puerperal, breast was few, lymphogranuloma inguinale sore.
Herba Kummerowiae Striatae: sweet in the mouth, pungent, micro-hardship, property is put down.Return liver, spleen, lung, kidney channel.For the herb of leguminous plant Herba Kummerowiae Striatae and perpendicular hair chicken.There is heat-clearing and toxic substances removing, invigorating spleen to remove dampness, effect of promoting blood circulation and hemostasis.For cold, fever, heat-damp in summer is vomited and diarrhoea, jaundice, carbuncle furuncle, dysentery, infantile malnutrition, stranguria with blood, spitting of blood, epistaxis, traumatic injury, leucorrhea with red and white discharge.
Flos Jasmini Sambac: acrid in the mouth, micro-sweet, warm in nature.Return spleen, stomach, Liver Channel.For the flower of Oleaceae plants jasmine.There is regulating QI to relieve pain, ward off effect of dirty dissipating depression of QI.For hindering in wet method, chest and diaphragm does not relax, and dysentery is suffered from abdominal pain, dizziness headache, conjunctival congestion, sore.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature.Return liver, gallbladder, lung meridian.For dry rhizome and the root of polygonaceae plant Rhizoma Polygoni Cuspidati.There is expelling wind and removing dampness, dissipating blood stasis analgesic therapy, effect of relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Herba Andrographis: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.For the dry aerial parts of acanthaceous plant Herba Andrographis.There is heat-clearing and toxic substances removing, removing heat from blood, effect of detumescence.For cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.For the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive, have loose bowels just clear, frequent fetal movement.
Flos Hemerocallis: sweet in the mouth, cool in nature.GUIXIN, liver, spleen channel.For the alabastrum of Liliaceae hemerocallis Radix hemerocalis plicatae.Containing the abundant necessary nutrient of human body such as pollen, sugar, protein, vitamin C, calcium, fat, carotene, aminoacid.There is dampness removing heat, antipyretic, effect of removing heat from blood.For oliguria with reddish urine, jaundice, chest and diaphragm dysphoria with smothery sensation, pacifies less and sleeps, bleeding hemorrhoids, carbuncle sore night.
Herba Biondiae henryi: taste is micro-pungent, warm in nature.Return liver, kidney channel.For the whole herb with root of Asclepiadaceae plant biondia hennriyi.There is dispelling wind and removing obstruction in the collateral, effect of promoting blood circulation and stopping pain.For anemofrigid-damp arthralgia, numb limbs and tense tendons cold type of pain, toothache, traumatic injury.
Caulis Spatholobi: bitter in the mouth, sweet, warm in nature.Return liver, kidney channel.For the dry rattan of leguminous plant spatholobus suberectus.Have and enrich blood, invigorate blood circulation, effect of dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Radix Fici beecheyanae: sweet in the mouth, pungent, warm in nature.Return lung, spleen, kidney channel.For the root of moraceae plants Fructus Fici Beecheyanae.There is replenishing QI to invigorate the spleen, promoting blood circulation to remove obstruction in the collateral, effect of expelling wind and removing dampness.Weak for overstrain, lack of appetite, agalactia, insufficiency of the spleen leucorrhea, proctoptosis, menoxenia, wind syndrome of head pain, traumatic injury, rheumatic arthralgia.
Radix Codonopsis lanceolatae: sweet in the mouth, pungent, property is put down.Return spleen, lung meridian.For the root of Campanulaceae Lac caprae seu ovis.There is supplementing QI and nourishing YIN, removing toxic substances and promoting subsidence of swelling, evacuation of pus, effect of lactogenesis.For spiritlessness and weakness, dizziness headache, lung abscess, acute mastitis, intestinal future, furuncle toxic swelling, throat moth, scrofula, puerperal, breast was few, leucorrhea, venom.
Herba Syneilesis Aconitifoliae: acrid in the mouth, hardship, slightly warm in nature.For the root herb of feverfew Herba Syneilesis Aconitifoliae.Have expelling wind and removing dampness, removing toxic substances is invigorated blood circulation, effect of reducing swelling and alleviating pain.For rheumatic numbness, limbs pain, traumatic injury, menoxenia, dysmenorrhea, swollen ulcer drug, scrofula, hemorrhoid.
Radix Flemingiae Philippinensis: sweet in the mouth, puckery, property is put down.Return lung, kidney, urinary bladder channel.For the root of leguminous plant Flemingia philippinensis.Can expelling wind and removing dampness, bone and muscle strengthening, effect of promoting blood circulation and detoxication.For rheumatic arthralgia, lumbar muscle strain, extremity flaccidity is soft, traumatic injury, laryngopharynx swelling and pain.
test examplein order to verify that the present invention treats the curative effect of atherosclerotic prescription, We conducted contrast test.Experiment sieving Carotid Artery Atherosclerotic Patients 200 people, through the even carotid IMT in various degree of color Doppler ultrasonography, what have even has Mottling formation, is divided into matched group and experimental group randomly, wherein experimental group has 150 people, and matched group has 50 people.Two groups of basic simlarity in sex, age, protopathy, the state of an illness etc., have comparability through statistical procedures.
Exclusion standard: the age was under-18s or more than 75 years old; To drug allergy person; Merge gouty nephropathy, renal insufficiency person; Merge severe primary disease and the insanes such as the heart, liver, kidney, brain and hemopoietic system; Curative effect or data not congruent affect the treatment evaluation or safety judgement person cannot be judged.
Experimental group is taken the present invention and is treated atherosclerotic prescription granule (embodiment 5), each 1 bag, every day 3 times, 7 days courses for the treatment of.Matched group adopts other drug, as vitamin E nicotinate capsule, compound three-vitamines linoleic acid soft gelatin capsule etc., and wherein vitamin E nicotinate capsule, oral, a 1-2 grain, 3 times on the one.Compound three-vitamines linoleic acid soft gelatin capsule, oral, one time 1,3 times on the one, one after each meal or follow the doctor's advice.
To 200 routine patients before the treatment after all adopt the bilateral carotid arteries of Color doppler ultrasound patient, the intima-media thickness (IMT) of neck arteries inner membrance is measured, tube wall IMT is measured in neck arteries, measure 5 times, to average (remarks: normal value≤0.9mm, arterial wall thickens and is defined as local 1.0mm≤IMT≤1.2mm, and atheromatous plaque is defined as local I MT >=1.2mm).
Before and after treatment, the change of IMT adopts t inspection, and p<0.05 is that difference has statistical significance.In experimentation, two groups of patients all do not find abnormal and other fortuitous events of obvious hepatic and renal function in the treatment and exit test, and before and after two groups of treatments, the situations of change of IMT are as shown in table 1:
Before and after table 1 liang group treatment, IMT change is compared
As can be seen from Table 1, the IMT value difference of two groups is few before the treatment, but there is larger change in two groups of IMT values after the treatment, wherein taking the experimental group that the present invention treats atherosclerotic prescription has IMT meansigma methods 1.22mm to be originally down to 0.94mm, successful, basic close to normal level 0.9mm, can conclude that most of patients has recovered normal; And the experimental group taking other drug is only down to 1.16mm by IMT meansigma methods 1.21mm originally, DeGrain.So the successful that the present invention treats atherosclerotic prescription is better than the effect of other drug.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat atherosclerotic prescription, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from: Rhizoma Alismatis 6-11 part; Herba mesonae chinensis 8-12 part; Radix cynanchi wilfordii 5-13 part; Herba Kummerowiae Striatae 8-14 part; Flos Jasmini Sambac 6-10 part; Rhizoma Polygoni Cuspidati 7-12 part; Herba Andrographis 9-13 part; Rhizoma Atractylodis Macrocephalae 8-12 part; Flos Hemerocallis 6-13 part; Herba Biondiae henryi 4-10 part; Caulis Spatholobi 7-13 part; Radix Fici beecheyanae 9-14 part; Radix Codonopsis lanceolatae 6-12 part; Herba Syneilesis Aconitifoliae 8-13 part; Radix Flemingiae Philippinensis 4-11 part.
2. prescription according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Rhizoma Alismatis 8-10 part; Herba mesonae chinensis 9-11 part; Radix cynanchi wilfordii 8-10 part; Herba Kummerowiae Striatae 10-12 part; Flos Jasmini Sambac 7-9 part; Rhizoma Polygoni Cuspidati 9-11 part; Herba Andrographis 10-12 part; Rhizoma Atractylodis Macrocephalae 9-11 part; Flos Hemerocallis 9-11 part; Herba Biondiae henryi 6-8 part; Caulis Spatholobi 9-11 part; Radix Fici beecheyanae 11-13 part; Radix Codonopsis lanceolatae 8-10 part; Herba Syneilesis Aconitifoliae 10-12 part; Radix Flemingiae Philippinensis 7-9 part.
3. prescription according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Rhizoma Alismatis 9 parts; Herba mesonae chinensis 10 parts; Radix cynanchi wilfordii 9 parts; Herba Kummerowiae Striatae 11 parts; Flos Jasmini Sambac 8 parts; Rhizoma Polygoni Cuspidati 10 parts; Herba Andrographis 11 parts; The Rhizoma Atractylodis Macrocephalae 10 parts; Flos Hemerocallis 10 parts; Herba Biondiae henryi 7 parts; Caulis Spatholobi 10 parts; Radix Fici beecheyanae 12 parts; Radix Codonopsis lanceolatae 9 parts; Herba Syneilesis Aconitifoliae 11 parts; Radix Flemingiae Philippinensis 8 parts.
4., according to the preparation method of the arbitrary described prescription powder of claim 1-3, it is characterized in that, step is as follows:
(1) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry, pulverize, cross 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);
(2) Herba mesonae chinensis, Herba Kummerowiae Striatae, Flos Jasmini Sambac, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) humus flava usta is placed in frying pan, moderate heat stirs 10-15 minute, add Radix cynanchi wilfordii, Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae, Radix Codonopsis lanceolatae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, sieve removes humus flava usta, porphyrize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae gross mass 3-5 doubly, the consumption being more preferably rice wine be Flos Hemerocallis, Herba Biondiae henryi and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(5) by step (1)-(4) gained medicated powder mix homogeneously, sterile packaged.
5., according to the preparation method of the arbitrary described prescription decoction of claim 1-3, it is characterized in that, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine of 30o-40o, moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, filters, sterile packaged.
6. preparation method according to claim 5, is characterized in that: the consumption of the preferred rice wine of step (4) is 3-5 times of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass, and the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times.
7., according to the preparation method of the arbitrary described prescription pill of claim 1-3, it is characterized in that, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass doubly, the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, be condensed into the thick paste that relative density is 1.10-1.30, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
8., according to the preparation method of the arbitrary described prescription tablet of claim 1-3, it is characterized in that, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass doubly, the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, be condensed into the thick paste that relative density is 1.10-1.30, make tablet.
9., according to the preparation method of the arbitrary described prescription granule of claim 1-3, it is characterized in that, step is as follows:
(1) Herba mesonae chinensis, Herba Kummerowiae Striatae, Herba Andrographis and Caulis Spatholobi are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and the Rhizoma Atractylodis Macrocephalae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Rhizoma Polygoni Cuspidati, Radix Fici beecheyanae and Radix Flemingiae Philippinensis, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Flos Hemerocallis and Herba Syneilesis Aconitifoliae are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass doubly, the consumption being more preferably rice wine is Flos Hemerocallis and Herba Syneilesis Aconitifoliae gross mass 4 times), moistening 3-5 days, takes out;
(5) Radix cynanchi wilfordii, Flos Jasmini Sambac, Herba Biondiae henryi and Radix Codonopsis lanceolatae are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, be concentrated into the thick paste that relative density is 1.10.-1.20, add simple syrup, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
10. preparation method according to claim 9, is characterized in that: the consumption of the preferred simple syrup of step (5) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
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| KR102355586B1 (en) * | 2021-05-07 | 2022-01-25 | 동의대학교 산학협력단 | Composition comprising syneilesis aconitifolia (bunge) maxim extract for preventing or treating brain neuronal disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335346A (en) * | 2011-09-01 | 2012-02-01 | 续卫杰 | Traditional Chinese medicinal preparation for treating cerebrovascular disease |
| CN103191367A (en) * | 2013-03-11 | 2013-07-10 | 温志民 | Collateral dredging and blood pressure reducing capsules |
-
2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335346A (en) * | 2011-09-01 | 2012-02-01 | 续卫杰 | Traditional Chinese medicinal preparation for treating cerebrovascular disease |
| CN103191367A (en) * | 2013-03-11 | 2013-07-10 | 温志民 | Collateral dredging and blood pressure reducing capsules |
Non-Patent Citations (2)
| Title |
|---|
| 崔晓丽: "《"三高"饮食+中医调养一本通》", 31 January 2014, 福建科学技术出版社 * |
| 林傲梵等: "《常见病健康管理答疑丛书 动脉粥样硬化预防与治疗151问》", 31 July 2013, 人民军医出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102355586B1 (en) * | 2021-05-07 | 2022-01-25 | 동의대학교 산학협력단 | Composition comprising syneilesis aconitifolia (bunge) maxim extract for preventing or treating brain neuronal disease |
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