CN105169214A - Traditional Chinese medicine composition for treating atherosclerosis, and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating atherosclerosis, and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a traditional Chinese medicine composition for treating atherosclerosis, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines: milkvetch root, cordyceps sinensis, cynanchum otophyllum, radix rehmanniae preparata, cortex moutan, campsis grandiflora, semen vaccariae, angelica, panax notoginseng, semen raphani, gynostemma pentaphyllum, jujube, fallopia multiflora (thunb.) harald, Chinese wolfberry, taxillus sutchuenensis (lecomte) danser, tuckahoe, pericarpium citri reticulatae, alisma orientalis, prunella vulgaris l, apocynum venetum, eucommia ulmoides, curcuma longa l, hawthorn, safflower, gingko, sophora flower, semen cassiae, achyranthes bidentata, clematis chinensis, aloe, leeches, coix seed and licorice root. According to the present invention, after the medicines are combined, the synergetic efficacy is provided, such that the rapid and effective atherosclerosis treatment purpose is achieved, wherein the total efficiency can achieve 98.5%.
Description
Technical field
the present invention relates to one and treat atherosclerotic Chinese medicine composition and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
atherosclerosis (atherosclerosis, AS) is one of arteriosclerotic three types, is the most common and has the disease of hazardness most.Atheroma or fibrous plaque is formed for feature with tunica intima, and mainly involve large artery trunks (elastic-type tremulous pulse---aorta and one-level branch thereof) and medium-sized artery (elastic force flesh type tremulous pulse---coronary artery, cerebral arteries etc.), make arterial wall hardening, luminal stenosis, middle film elasticity weakens, and serious complication can be caused, comprise ischemic heart desease, myocardial infarction, apoplexy (comprising cerebral infarction and cerebral hemorrhage etc.) and extremity gangrene etc.Being most important one common in one group of arteriosclerotic angiopathy, is exactly arterial wall deposited the lipid (cholesterol, cholesteryl ester and phospholipid) of one deck as milled congee sample, makes the pathological changes that arterial elasticity lowers, tube chamber narrows.Be characterized in getting involved arterial disease from inner membrance.General first have that lipid and compound saccharide gather, hemorrhage and thrombosis, proliferation of fibrous tissue and calcinosis, and having medial transformation gradually and calcification; pathological changes often involves elasticity and large medium muscular artery; be enough to obstructing arterial chamber once develop into, then the tissue supplied of this tremulous pulse or organ are by ischemia or necrosis.Because the lipid outward appearance gathered at endarterium is yellow medicated porridge sample, be therefore called atherosclerosis.These pathological changes, Chinese medicine thinks the category belonging to " blood stasis ", " expectorant is turbid ".Hypertension promotes that atherosclerosis occurs, the important factor of development, and tremulous pulse caused narrowly causes secondary hypertension because of atherosis.Therefore interact therebetween, promote mutually, on very close terms.Hypertension promotes atherosclerosis, is multiplely born in large, medium-sized artery, comprises these fortress passages such as the coronary artery of heart, the cerebral arteries of head.Hypertension causes blood to impact tunica intima, causes tube wall thickening, tube chamber attenuates.Tube wall inner membrance impaired rear be easily cholesterol, lipidosis, increased the weight of the formation of atherosclerotic plaque.Therefore, hypertension is atherosclerotic risk factor.
in treatment, doctor trained in Western medicine generally takes Drug therapy: (1) blood lipid-lowering medicine 1. Statins; 2. the special class of shellfish; 3. nicotinic acid; 4. cholestyramine; 5. clofibrate; 6. unsaturated fatty acid is as linoleic acid, lipid level and heart arteries and veins pleasure etc.; 7. propylene glycol alginate sodium sulfate.(2) antiplatelet drug 1. aspirin; 2. persantin; 3. clopidogrel; 4. Xi Luota.(3) hirudin is separately had to have antiplatelet effects, platelet aggregation, play a significant role in atherosclerotic development, vascular endothelial cell damage (comprising atheromatous plaque to break) and endothelial dysfunction are the first steps causing platelet activation.Above situation makes subendothelial collagen tissue expose, and natural hirudin, by the platelet activation of enzyme induction anticoagulant, has clear and definite anticoagulant effect.
but western medical treatment side effect is large, cures the symptoms, not the disease.In all kinds of angiopathys that treatment atherosclerosis causes, development and perfect tcm therapy mainly contain following several: activating blood and removing stasis Method, method of dissipating heat and detoxifying, dispelling cold by warming the meridian method, warming the kidney and strengthening the spleen method, promoting diuresis to eliminate damp pathogen method, the method for dissipating hard mass, spasmolytic dredging collateral method, benefiting qi and nourishing blood method.Wherein, activating blood and removing stasis Method is most widely used, and mechanism is the most ripe, is also the most popular clinical a kind of therapy at present.But the atherosclerotic Chinese medicine effect for the treatment of is not remarkable at present, therefore, urgently works out the significant Chinese medicine composition of a kind of therapeutic effect.
Summary of the invention
the object of the present invention is to provide one to treat atherosclerotic Chinese medicine composition and preparation method thereof, all select natural Chinese medicinal herb, can rapid, effective treatment atherosclerosis.
the technical scheme that technical solution problem of the present invention is taked is:
one treats atherosclerotic Chinese medicine composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:
radix Astragali 20-30, Cordyceps 15-25, Radix Paeoniae Alba 5-15, Radix Rehmanniae Preparata 10-20, Cortex Moutan 10-20, Flos Campsis 8-12, Semen Vaccariae 8-12, Radix Angelicae Sinensis 5-12, Radix Notoginseng 4-8, Semen Raphani 4-8, Herb Gynostemmae Pentaphylli 5-15, Fructus Jujubae 10-20, Radix Polygoni Multiflori 10-15, Fructus Lycii 10-20, Herba Taxilli 10-20, Poria 15-25, Pericarpium Citri Reticulatae 5-15, Rhizoma Alismatis 3-8, Spica Prunellae 8-12, Herba Apocyni veneti 10-20, Cortex Eucommiae 10-20, Rhizoma Curcumae Longae 8-12, Fructus Crataegi 8-12, Flos Carthami 5-12, Semen Ginkgo 10-20, Flos Sophorae 10-20, Semen Cassiae 10-20, Radix Achyranthis Bidentatae 10-20, Radix Clematidis 10-20, Aloe 8-12, Hirudo 5-12, Semen Coicis 25-35, Radix Glycyrrhizae 10-20.
further, be made up of the Chinese medicine of following weight portion:
the Radix Astragali 25, Cordyceps 20, the Radix Paeoniae Alba 10, Radix Rehmanniae Preparata 15, Cortex Moutan 15, Flos Campsis 10, Semen Vaccariae 10, Radix Angelicae Sinensis 9, Radix Notoginseng 6, Semen Raphani 6, Herb Gynostemmae Pentaphylli 8, Fructus Jujubae 15, Radix Polygoni Multiflori 12, Fructus Lycii 15, Herba Taxilli 15, Poria 18, Pericarpium Citri Reticulatae 8, Rhizoma Alismatis 5, Spica Prunellae 10, Herba Apocyni veneti 15, the Cortex Eucommiae 15, Rhizoma Curcumae Longae 10, Fructus Crataegi 10, Flos Carthami 9, Semen Ginkgo 15, Flos Sophorae 15, Semen Cassiae 15, Radix Achyranthis Bidentatae 15, Radix Clematidis 15, Aloe 10, Hirudo 9, Semen Coicis 30, Radix Glycyrrhizae 15.
further, be made up of the Chinese medicine of following weight portion:
the Radix Astragali 20, Cordyceps 15, the Radix Paeoniae Alba 15, Radix Rehmanniae Preparata 20, Cortex Moutan 20, Flos Campsis 12, Semen Vaccariae 12, Radix Angelicae Sinensis 5, Radix Notoginseng 4, Semen Raphani 4, Herb Gynostemmae Pentaphylli 5, Fructus Jujubae 10, Radix Polygoni Multiflori 10, Fructus Lycii 10, Herba Taxilli 20, Poria 15, Pericarpium Citri Reticulatae 15, Rhizoma Alismatis 8, Spica Prunellae 12, Herba Apocyni veneti 20, the Cortex Eucommiae 10, Rhizoma Curcumae Longae 8, Fructus Crataegi 12, Flos Carthami 12, Semen Ginkgo 20, Flos Sophorae 10, Semen Cassiae 10, Radix Achyranthis Bidentatae 10, Radix Clematidis 10, Aloe 12, Hirudo 5, Semen Coicis 25, Radix Glycyrrhizae 10.
further, be made up of the Chinese medicine of following weight portion:
the Radix Astragali 30, Cordyceps 25, the Radix Paeoniae Alba 5, Radix Rehmanniae Preparata 10, Cortex Moutan 10, Flos Campsis 8, Semen Vaccariae 8, Radix Angelicae Sinensis 12, Radix Notoginseng 8, Semen Raphani 8, Herb Gynostemmae Pentaphylli 15, Fructus Jujubae 20, Radix Polygoni Multiflori 15, Fructus Lycii 20, Herba Taxilli 10, Poria 25, Pericarpium Citri Reticulatae 5, Rhizoma Alismatis 3, Spica Prunellae 8, Herba Apocyni veneti 10, the Cortex Eucommiae 20, Rhizoma Curcumae Longae 12, Fructus Crataegi 8, Flos Carthami 5, Semen Ginkgo 10, Flos Sophorae 20, Semen Cassiae 20, Radix Achyranthis Bidentatae 20, Radix Clematidis 20, Aloe 8, Hirudo 12, Semen Coicis 35, Radix Glycyrrhizae 20.
further, be made up of the Chinese medicine of following weight portion:
the Radix Astragali 22, Cordyceps 19, the Radix Paeoniae Alba 9, Radix Rehmanniae Preparata 13, Cortex Moutan 15, Flos Campsis 10, Semen Vaccariae 8, Radix Angelicae Sinensis 12, Radix Notoginseng 4, Semen Raphani 6, Herb Gynostemmae Pentaphylli 10, Fructus Jujubae 15, Radix Polygoni Multiflori 13, Fructus Lycii 15, Herba Taxilli 15, Poria 22, Pericarpium Citri Reticulatae 10, Rhizoma Alismatis 6, Spica Prunellae 10, Herba Apocyni veneti 15, the Cortex Eucommiae 15, Rhizoma Curcumae Longae 10, Fructus Crataegi 10, Flos Carthami 5, Semen Ginkgo 10, Flos Sophorae 20, Semen Cassiae 16, Radix Achyranthis Bidentatae 10, Radix Clematidis 15, Aloe 10, Hirudo 9, Semen Coicis 29, Radix Glycyrrhizae 12.
present invention also offers a kind of preparation method for the treatment of atherosclerotic Chinese medicine composition, it is characterized in that, comprise the following steps:
1. raw material is taken according to above-mentioned weight portion;
2. by step 1. described raw material add 3 times of water soakings 2 hours, decocting in water 30 minutes, pours out medicinal liquid; Add 1.5 times of decocting in water 30 minutes again, pour out medicinal liquid; Twice medicinal liquid amalgamation rises, and obtains the atherosclerotic Chinese medicine composition for the treatment of of the present invention.
instructions of taking: above-mentioned Chinese medicine composition, respectively at half an hour before breakfast, is taken for after supper two hours.Serveing on 15 days is a course for the treatment of.
pharmacological action:
the Radix Astragali: warm in nature, sweet in the mouth.Tonifying Qi and lifting yang, benefit defends consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, diuretic detumescent.Cure mainly weakness of the spleen and stomach, lack of appetite asthenia, deficiency of vital energy blood prostration, exterior deficiency spontaneous perspiration, night sweat.
cordyceps: nature and flavor are sweet is flat.Return lung, kidney channel.Function cures mainly: invigorating the lung and the kidney, hemostasis and phlegm.For chronic cough dyspnea due to deficiency, chronic cough is spat blood, impotence and seminal emission, soreness of waist and knee joint.
the Radix Paeoniae Alba: bitter, sour, is slightly cold.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
radix Rehmanniae Preparata: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
cortex Moutan: bitter, pungent, is slightly cold.Gui Jing: GUIXIN, liver, kidney channel.Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.
flos Campsis: nature and flavor are sweet, sour, cold.Return liver, pericardium channel.Function cures mainly: removing heat from blood, and blood stasis dispelling is dispeled the wind.For menoxenia, Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.
semen Vaccariae: bitter is flat.Return liver, stomach warp.Function cures mainly: promoting blood circulation to restore menstrual flow, and stimulating milk secretion is subsided a swelling.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.
radix Angelicae Sinensis: sweet, acrid, warm.Enter the heart, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
radix Notoginseng: sweet, the micro-hardship of nature and flavor, temperature.Return liver, stomach warp.Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
semen Raphani: nature and flavor are pungent, sweet, flat.Return lung, spleen, stomach warp.Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
herb Gynostemmae Pentaphylli: cold in nature, bitter in the mouth.Function cures mainly: eliminating inflammation and expelling toxin, eliminating phlegm and stopping cough.Existing multiplexly make strengthening by means of tonics medicine.
fructus Jujubae: sweet, temperature.Enter spleen, stomach warp.Spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid, adjusts battalion to defend, separates poison of drug.Control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation.Married woman's stolen goods are hot-tempered.
radix Polygoni Multiflori: nature and flavor are bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function cures mainly: removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
fructus Lycii: sweet is flat.Return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
herba Taxilli: invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive.Control soreness of waist and knee joint, muscles and bones flaccidity is weak, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia.
poria: sweet light is flat.Enter the heart, spleen, lung meridian.Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.
pericarpium Citri Reticulatae: warm in nature, bitter in the mouth, pungent.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough ant phlegm.
rhizoma Alismatis: sweet, cold.Gui Jing: return kidney, urinary bladder channel.Function cures mainly: diuresis, clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria; Hyperlipidemia.
spica Prunellae: nature and flavor are pungent, bitter, cold.Return liver, gallbladder meridian.Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Herba Apocyni veneti: sweet-bitter flavor, property is put down, slightly poisonous; Relieve inflammation or internal heat, blood pressure lowering, heart tonifying, diuresis.Control heart disease, hypertension, neurasthenia, hepatitis abdominal distention, nephritis edema.
the Cortex Eucommiae: enter liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, vaginal bleeding during pregnancy for falling, frequent fetal movement, hypertension.
rhizoma Curcumae Longae: nature and flavor are pungent, bitter, temperature.Return spleen, Liver Channel.Function cures mainly: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea ， WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.
fructus Crataegi: sour, sweet, tepor.Gui Jing: return spleen, stomach, Liver Channel.Function cures mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
flos Carthami: pungent, temperature.Enter the heart, Liver Channel.Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea ， mass in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
semen Ginkgo: nature and flavor are sweet, bitter, puckery is flat; Poisonous.Return lung meridian.Function cures mainly: astringing lung QI for relieving asthma, and leukorrhagia stopping is turbid, urine reducing.Breath with cough for abundant expectoration, leukorrhagia nebulousurine, enuresis frequent micturition.
flos Sophorae: nature and flavor are bitter, are slightly cold.Return liver, large intestine channel.Function cures mainly: cooling blood for hemostasis, purging liver-fire.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, has a headache dizzy.
semen Cassiae: bitter sweet, cool.Enter liver, kidney channel.Have liver heat removing, improving eyesight, dispel the wind, effect of relieving constipation.Control the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
radix Achyranthis Bidentatae: sweetness and bitterness acid is flat.Enter liver, kidney channel.Life uses dissipating blood stasis blood, subduing inflammation.Control gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis is suffered from abdominal pain, sore throat, carbuncle, traumatic injury.Ripe invigorating the liver and kidney, bone and muscle strengthening.Control waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.
radix Clematidis: Xin Xian, temperature, poisonous.Enter urinary bladder channel.Wind-damp dispelling, the meridian dredging, expectorant saliva, the loose hypochondriac lump.Control gout, insensitive impediment, chills and pain of the waist and kness ， ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
aloe: nature and flavor are bitter, cold.Return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
hirudo: nature and flavor are salty, bitter, flat; Slightly poisonous.Return Liver Channel.Function cures mainly: removing blood stasis, and removing blood stasis stimulates the menstrual flow.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.
semen Coicis: sweet light, cool.Enter spleen, lung, kidney channel.Spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, grows and coughs lung moistening, and emergency is detoxified, and is in harmonious proportion hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.Radix Glycyrrhizae agent have antiinflammatory and resistance state reflection function, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Enoxolone has the effect of desoxycortone class, has good effects to chronic adrenocortical insufficiency.The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.
the traditional Chinese medical science, atherosclerotic reason is: 1, intemperance of taking food, throws off restraint food Sorghum vulgare Pers. savoury, or hungry full variable, with the passing of time impairing the spleen and stomach, and transporting mistake department, diet can not change angry blood, is condensed into expectorant, and phlegm-damp impregnated in blood vessels, and the expectorant stasis of blood hands over resistance, and sends out primary disease.2, caused by liver and kidney deficiency, worn with age or prolonged illness impairment caused by overstrain and Liver and kidney, yang deficiency can not promote the circulation of qi and water, and temperature fortune blood vessels, the deficiency of YIN can not nourish blood vessels, and blood vessels damage, stagnant in the expectorant stasis of blood, therefore sends out primary disease.3, internal injury caused by excess of seven emotions, angry irritability stasis of being worried, qi depression to blood stasis, blood vessels are smooth, disorder of QI movement, and body fluid metabolism is hindered and causes phlegm-damp and stagnate, and phlegm and blood stasis, in passages through which vital energy circulates, is sent out for this reason sick.Generally speaking, expectorant is turbid is atherosclerotic important pathologic basis with blood stasis.Atherosclerosis, generally along with hyperlipidemia, obesity, hypertension, diabetes etc., therefore, over the course for the treatment of, dialectical treating.Therefore, drug main of the present invention will with dispelling phlegm and eliminating dampness, blood circulation promoting and blood stasis dispelling, nourishing liver and kidney, invigorating qi and benefiting blood for the rule for the treatment of, Rhizoma Alismatis, Spica Prunellae, Herba Apocyni veneti, the Cortex Eucommiae, Rhizoma Curcumae Longae, Fructus Crataegi, Flos Carthami, Semen Ginkgo, Flos Sophorae, Semen Cassiae, Radix Achyranthis Bidentatae, has effect of blood pressure lowering, blood fat; Cortex Moutan, Flos Campsis, Semen Vaccariae, Radix Angelicae Sinensis, Radix Notoginseng, Semen Raphani (also tool has efficacy in lowering high blood pressure) promoting blood circulation by removing blood stasis; Herb Gynostemmae Pentaphylli, the Radix Astragali, Radix Rehmanniae Preparata, Fructus Jujubae then can benefiting vital QI and blood; Semen Coicis can damp eliminating, etc., the present invention is by after above drug regimen, and drug effect synergism, reaches and treat atherosclerotic object fast and effectively, and total effective rate can reach 98.5%.
below in conjunction with clinical data and model case, beneficial effect of the present invention is further illustrated.
one, clinical observation
choose to be diagnosed as atherosclerotic patient 200 example, wherein male 118 example, women 82 example, the age be 31-78 year.
two, Therapeutic Method
take Chinese medicine composition of the present invention, respectively at half an hour before breakfast, within after supper two hours, take.Serveing on 15 days is a course for the treatment of.
three, diagnostic criteria:
risk factors for atherosclerosis is as follows:
1, Anomalous lipid metablism: Anomalous lipid metablism is generally acknowledged risk factors for atherosclerosis, increasing of main finger total plasma cholesterol and triglyceride, wherein especially cholesterol plays a crucial role, and the oxidative modification of LDL is the key startup factor of atherogenesis.2, hypertension: hypertension, mainly through injured blood vessel endothelium, produces and accelerates atherosclerosis.Easily there is atherosclerosis in hyperpietic, time of occurrence early and degree weight, is generally apt to occur in vascular bifurcation place and knee.3, diabetes (pathoglycemia): diabetes take hyperglycemia as the metabolism disorder disease of feature.High insulin levels can the growth of stimulating endothelial cell and smooth muscle cell, and hyperglycemia and insulin resistant can endothelial cell injuries.Be rich in vascular cell adhesion molecule in Diabetes Mellitus, the latter participates in and promotes atherosclerotic formation.4, smoking: smoking (or smog exposure) can increase the expression of multiple adhesion factor, and causes dysfunction of platelet, and then destroy vascular endothelial cell, induction smooth muscle cell proliferation, causes vasomotor dysfunction, promotes atherosclerotic formation.5, inherited genetic factors: atherosclerosis has Familial aggregation phenomenon, several genes all may promote atherosclerotic formation.In family, a people or many people suffer from cerebrovascular disease will obviously increase the risk of its cerebral atherosclerosis.6, the age: atherosclerosis with the age increase and increase, age >45 year cerebral atherosclerosis development be obvious ascendant trend.7, heavy drinking: heavy drinking can promote platelet aggregation, affects fibrinogen activity, excites blood clotting process, increases acetaldehyde to the Oxidation of LDL.In addition, heavy drinking also has harmful effect for blood pressure.8, obesity, Bad Eating Habit: obesity (high BMI person), Bad Eating Habit (such as high heat, high-fat food, as meat or fry) how with disorders of lipid metabolism, thus promote atherogenesis.9, move: the sports of rule can improve endothelial function, reduce blood pressure, alleviate insulin resistant, improve lipid metabolism and contribute to losing weight.The aerobatic exercise (aerobatic exercise refers to adhere to weekly more than 3 times and 3 times, at every turn at least 30min) lacking rule easily causes atherosclerosis.10, homocysteine: homocysteine is a kind of blood vessel injury acidic amino acid, directly can cause vascular endothelial cell damage and vascular function extremely, promote atherosclerotic generation and development.
diagnosis: 1, have more than two or two tremulous pulse medicated porridge auspicious sclerosis risk factors: or a risk factors for atherosclerosis merges clear and definite corresponding clinical symptoms.
2, carotid artery auscultation has positive discovery: or Inter arm difference >20mmHg (lmmHg=0.133kPa).
3, carotid ultrasound finds that CIMT thickens, Mottling formation: or carotid ultrasound and TCD find angiostenosis or inaccessiblely wait cerebral atherosclerosis to show.
4, imaging examination (imaging of CTA/MRA/DSA/MRI high-resolution cranium inside/outside blood vessel wall) the atherosis change of arteries visible.
5．ABI<0.9。
diagnosing atherosclerotic need meet following 3: 1 or 1+2 simultaneously; 3,4 or 3+4; Except non-atherosclerotic vascular disease become; 5 is supportive evidence.
four, criterion of therapeutical effect
1, effective: body constitution strengthens, nervous, cardiopalmus, gas tight, heart beating is overrun, numb limbs and tense tendons, myocardial ischemia, the symptom such as to sleep not good enough is obviously alleviated; Or: symptom, sign obviously alleviate, and blood fat, Hemorheology result are all normal;
the symptom such as 2, effective: body constitution strengthens, nervous, cardiopalmus, gas are tight, numb is alleviated to some extent; Or: symptom, sign partial rcsponse, lipid examination cholesterol (TC) declines>=10%, triglyceride (TG) declines>=20%, HDL-C (HDL ~ C)>=10%, low-density lipoprotein cholesterol (LDL ~ C)>=20%, Hemorheology result transfers warning to by danger or notes;
3, invalid: symptom is substantially unchanged; Or: symptom, sign are without obvious alleviation, and lipid examination does not reach effective standard, and Hemorheology inspection is not improved.
five, therapeutic outcome:
effective 146 people, obvious effective rate 73%; Effective 51 people, effective percentage 25.5%; Invalid 3 people, inefficiency 1.5%; Total effective rate 98.5%.
model case
case 1: Lee, man, 58 years old, because intermittent claudication increases the weight of to be admitted to hospital for 1 year for 5 years.Before 5 years there is left lower extremity intermittent claudication in patient, and pulsation of foot dorsal artery disappears, and walks about 300 meters.Go to a doctor and do color-Doppler ultrasound in locality province Grade A hospital and show: “ left popliteal artery Serious Stenosis, intra-arterial atherosclerosis plaque forming ", diagnosis " for left lower extremity atherosclerotic occlusive disease "; after taking Chinese medicine 2 of the present invention course for the treatment of; remission, after continuing to take for 3 courses for the treatment of, transference cure.
case 2: Wu so-and-so, female 65 years old, suffers from the multiple diseases such as hypertension, diabetes, cholecystitis, cholelithiasis, has plenty medicine everyday, when in March, 2014, be diagnosed as atherosclerosis.Continue to take Chinese medicine 3 of the present invention course for the treatment of, remission, after continuing to take for 3 courses for the treatment of, transference cure, hypertension symptom also disappears, and diabetes also have alleviation to a certain degree.
case 3: the Qin, female, 56 years old, suffers from hypertension, is diagnosed as atherosclerosis the year before in municipal hospital, continues to take Chinese medicine 2 of the present invention course for the treatment of, remission, and after continuing to take for 3 courses for the treatment of, transference cure, hypertension symptom also disappears, recurrence of following up a case by regular visits to that so far there are no.
Detailed description of the invention
embodiment 1:
formula:
the Radix Astragali 25, Cordyceps 20, the Radix Paeoniae Alba 10, Radix Rehmanniae Preparata 15, Cortex Moutan 15, Flos Campsis 10, Semen Vaccariae 10, Radix Angelicae Sinensis 9, Radix Notoginseng 6, Semen Raphani 6, Herb Gynostemmae Pentaphylli 8, Fructus Jujubae 15, Radix Polygoni Multiflori 12, Fructus Lycii 15, Herba Taxilli 15, Poria 18, Pericarpium Citri Reticulatae 8, Rhizoma Alismatis 5, Spica Prunellae 10, Herba Apocyni veneti 15, the Cortex Eucommiae 15, Rhizoma Curcumae Longae 10, Fructus Crataegi 10, Flos Carthami 9, Semen Ginkgo 15, Flos Sophorae 15, Semen Cassiae 15, Radix Achyranthis Bidentatae 15, Radix Clematidis 15, Aloe 10, Hirudo 9, Semen Coicis 30, Radix Glycyrrhizae 15.
preparation method: 1. take raw material according to above-mentioned weight portion;
2. by step 1. described raw material add 3 times of water soakings 2 hours, decocting in water 30 minutes, pours out medicinal liquid; Add 1.5 times of decocting in water 30 minutes again, pour out medicinal liquid; Twice medicinal liquid amalgamation rises, and obtains the atherosclerotic Chinese medicine composition for the treatment of of the present invention.
instructions of taking: above-mentioned Chinese medicine composition, respectively at half an hour before breakfast, is taken for after supper two hours.Serveing on 15 days is a course for the treatment of.
embodiment 2
formula: the Radix Astragali 20, Cordyceps 15, the Radix Paeoniae Alba 15, Radix Rehmanniae Preparata 20, Cortex Moutan 20, Flos Campsis 12, Semen Vaccariae 12, Radix Angelicae Sinensis 5, Radix Notoginseng 4, Semen Raphani 4, Herb Gynostemmae Pentaphylli 5, Fructus Jujubae 10, Radix Polygoni Multiflori 10, Fructus Lycii 10, Herba Taxilli 20, Poria 15, Pericarpium Citri Reticulatae 15, Rhizoma Alismatis 8, Spica Prunellae 12, Herba Apocyni veneti 20, the Cortex Eucommiae 10, Rhizoma Curcumae Longae 8, Fructus Crataegi 12, Flos Carthami 12, Semen Ginkgo 20, Flos Sophorae 10, Semen Cassiae 10, Radix Achyranthis Bidentatae 10, Radix Clematidis 10, Aloe 12, Hirudo 5, Semen Coicis 25, Radix Glycyrrhizae 10.
preparation and instructions of taking are with embodiment 1.
embodiment 3
formula: the Radix Astragali 30, Cordyceps 25, the Radix Paeoniae Alba 5, Radix Rehmanniae Preparata 10, Cortex Moutan 10, Flos Campsis 8, Semen Vaccariae 8, Radix Angelicae Sinensis 12, Radix Notoginseng 8, Semen Raphani 8, Herb Gynostemmae Pentaphylli 15, Fructus Jujubae 20, Radix Polygoni Multiflori 15, Fructus Lycii 20, Herba Taxilli 10, Poria 25, Pericarpium Citri Reticulatae 5, Rhizoma Alismatis 3, Spica Prunellae 8, Herba Apocyni veneti 10, the Cortex Eucommiae 20, Rhizoma Curcumae Longae 12, Fructus Crataegi 8, Flos Carthami 5, Semen Ginkgo 10, Flos Sophorae 20, Semen Cassiae 20, Radix Achyranthis Bidentatae 20, Radix Clematidis 20, Aloe 8, Hirudo 12, Semen Coicis 35, Radix Glycyrrhizae 20.
preparation and instructions of taking are with embodiment 1.
embodiment 4:
formula: the Radix Astragali 22, Cordyceps 19, the Radix Paeoniae Alba 9, Radix Rehmanniae Preparata 13, Cortex Moutan 15, Flos Campsis 10, Semen Vaccariae 8, Radix Angelicae Sinensis 12, Radix Notoginseng 4, Semen Raphani 6, Herb Gynostemmae Pentaphylli 10, Fructus Jujubae 15, Radix Polygoni Multiflori 13, Fructus Lycii 15, Herba Taxilli 15, Poria 22, Pericarpium Citri Reticulatae 10, Rhizoma Alismatis 6, Spica Prunellae 10, Herba Apocyni veneti 15, the Cortex Eucommiae 15, Rhizoma Curcumae Longae 10, Fructus Crataegi 10, Flos Carthami 5, Semen Ginkgo 10, Flos Sophorae 20, Semen Cassiae 16, Radix Achyranthis Bidentatae 10, Radix Clematidis 15, Aloe 10, Hirudo 9, Semen Coicis 29, Radix Glycyrrhizae 12.
preparation and instructions of taking are with embodiment 1.
Claims (6)
1. treat an atherosclerotic Chinese medicine composition, it is characterized in that, be made up of the Chinese medicine of following weight portion:
Radix Astragali 20-30, Cordyceps 15-25, Radix Paeoniae Alba 5-15, Radix Rehmanniae Preparata 10-20, Cortex Moutan 10-20, Flos Campsis 8-12, Semen Vaccariae 8-12, Radix Angelicae Sinensis 5-12, Radix Notoginseng 4-8, Semen Raphani 4-8, Herb Gynostemmae Pentaphylli 5-15, Fructus Jujubae 10-20, Radix Polygoni Multiflori 10-15, Fructus Lycii 10-20, Herba Taxilli 10-20, Poria 15-25, Pericarpium Citri Reticulatae 5-15, Rhizoma Alismatis 3-8, Spica Prunellae 8-12, Herba Apocyni veneti 10-20, Cortex Eucommiae 10-20, Rhizoma Curcumae Longae 8-12, Fructus Crataegi 8-12, Flos Carthami 5-12, Semen Ginkgo 10-20, Flos Sophorae 10-20, Semen Cassiae 10-20, Radix Achyranthis Bidentatae 10-20, Radix Clematidis 10-20, Aloe 8-12, Hirudo 5-12, Semen Coicis 25-35, Radix Glycyrrhizae 10-20.
2. one according to claim 1 treats atherosclerotic Chinese medicine composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:
The Radix Astragali 25, Cordyceps 20, the Radix Paeoniae Alba 10, Radix Rehmanniae Preparata 15, Cortex Moutan 15, Flos Campsis 10, Semen Vaccariae 10, Radix Angelicae Sinensis 9, Radix Notoginseng 6, Semen Raphani 6, Herb Gynostemmae Pentaphylli 8, Fructus Jujubae 15, Radix Polygoni Multiflori 12, Fructus Lycii 15, Herba Taxilli 15, Poria 18, Pericarpium Citri Reticulatae 8, Rhizoma Alismatis 5, Spica Prunellae 10, Herba Apocyni veneti 15, the Cortex Eucommiae 15, Rhizoma Curcumae Longae 10, Fructus Crataegi 10, Flos Carthami 9, Semen Ginkgo 15, Flos Sophorae 15, Semen Cassiae 15, Radix Achyranthis Bidentatae 15, Radix Clematidis 15, Aloe 10, Hirudo 9, Semen Coicis 30, Radix Glycyrrhizae 15.
3. one according to claim 1 treats atherosclerotic Chinese medicine composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:
The Radix Astragali 20, Cordyceps 15, the Radix Paeoniae Alba 15, Radix Rehmanniae Preparata 20, Cortex Moutan 20, Flos Campsis 12, Semen Vaccariae 12, Radix Angelicae Sinensis 5, Radix Notoginseng 4, Semen Raphani 4, Herb Gynostemmae Pentaphylli 5, Fructus Jujubae 10, Radix Polygoni Multiflori 10, Fructus Lycii 10, Herba Taxilli 20, Poria 15, Pericarpium Citri Reticulatae 15, Rhizoma Alismatis 8, Spica Prunellae 12, Herba Apocyni veneti 20, the Cortex Eucommiae 10, Rhizoma Curcumae Longae 8, Fructus Crataegi 12, Flos Carthami 12, Semen Ginkgo 20, Flos Sophorae 10, Semen Cassiae 10, Radix Achyranthis Bidentatae 10, Radix Clematidis 10, Aloe 12, Hirudo 5, Semen Coicis 25, Radix Glycyrrhizae 10.
4. one according to claim 1 treats atherosclerotic Chinese medicine composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:
The Radix Astragali 30, Cordyceps 25, the Radix Paeoniae Alba 5, Radix Rehmanniae Preparata 10, Cortex Moutan 10, Flos Campsis 8, Semen Vaccariae 8, Radix Angelicae Sinensis 12, Radix Notoginseng 8, Semen Raphani 8, Herb Gynostemmae Pentaphylli 15, Fructus Jujubae 20, Radix Polygoni Multiflori 15, Fructus Lycii 20, Herba Taxilli 10, Poria 25, Pericarpium Citri Reticulatae 5, Rhizoma Alismatis 3, Spica Prunellae 8, Herba Apocyni veneti 10, the Cortex Eucommiae 20, Rhizoma Curcumae Longae 12, Fructus Crataegi 8, Flos Carthami 5, Semen Ginkgo 10, Flos Sophorae 20, Semen Cassiae 20, Radix Achyranthis Bidentatae 20, Radix Clematidis 20, Aloe 8, Hirudo 12, Semen Coicis 35, Radix Glycyrrhizae 20.
5. one according to claim 1 treats atherosclerotic Chinese medicine composition, it is characterized in that, is made up of the Chinese medicine of following weight portion:
The Radix Astragali 22, Cordyceps 19, the Radix Paeoniae Alba 9, Radix Rehmanniae Preparata 13, Cortex Moutan 15, Flos Campsis 10, Semen Vaccariae 8, Radix Angelicae Sinensis 12, Radix Notoginseng 4, Semen Raphani 6, Herb Gynostemmae Pentaphylli 10, Fructus Jujubae 15, Radix Polygoni Multiflori 13, Fructus Lycii 15, Herba Taxilli 15, Poria 22, Pericarpium Citri Reticulatae 10, Rhizoma Alismatis 6, Spica Prunellae 10, Herba Apocyni veneti 15, the Cortex Eucommiae 15, Rhizoma Curcumae Longae 10, Fructus Crataegi 10, Flos Carthami 5, Semen Ginkgo 10, Flos Sophorae 20, Semen Cassiae 16, Radix Achyranthis Bidentatae 10, Radix Clematidis 15, Aloe 10, Hirudo 9, Semen Coicis 29, Radix Glycyrrhizae 12.
6., according to a preparation method for the arbitrary described atherosclerotic Chinese medicine composition for the treatment of of claim 1-5, it is characterized in that, comprise the following steps:
1. raw material is taken according to the arbitrary described weight portion of claim 1-5;
2. by step 1. described raw material add 3 times of water soakings 2 hours, decocting in water 30 minutes, pours out medicinal liquid; Add 1.5 times of decocting in water 30 minutes again, pour out medicinal liquid; Twice medicinal liquid amalgamation rises, and obtains the atherosclerotic Chinese medicine composition for the treatment of of the present invention.
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| CN105617272A (en) * | 2016-02-18 | 2016-06-01 | 季新玲 | Pharmaceutical preparation for treating atherosclerosis and application thereof |
| CN105617271A (en) * | 2016-02-18 | 2016-06-01 | 湖南中医药大学 | Health wine for preventing and treating atherosclerosis and preparation method thereof |
| CN106974286A (en) * | 2017-05-03 | 2017-07-25 | 贵阳中医学院 | Gingko plant extraction liquid, fermented yoghourt and preparation method thereof |
| CN107296196A (en) * | 2017-08-23 | 2017-10-27 | 宁波甬鸿优尚餐饮有限公司 | A kind of auxiliary treatment artery sclerosis compound sophora flower tuckahoe health care tea-drinking and preparation method thereof |
| CN111450183A (en) * | 2020-05-28 | 2020-07-28 | 仲崇允 | A Chinese medicinal composition for treating hyperlipidemia and atherosclerosis |
| CN112136998A (en) * | 2020-09-02 | 2020-12-29 | 岳康医疗生物科技有限公司 | Formula and preparation method of solid beverage for assisting in reducing blood fat and improving blood circulation |
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| CN112136998A (en) * | 2020-09-02 | 2020-12-29 | 岳康医疗生物科技有限公司 | Formula and preparation method of solid beverage for assisting in reducing blood fat and improving blood circulation |
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