CN104645091A - Capsule for treating hypertension - Google Patents

Abstract

The invention discloses a capsule for treating hypertension. The capsule is characterized in that the capsule is prepared from the following traditional Chinese medicinal raw materials, by weight, 2 parts of radix astragali, 20 parts of red sage root, 6 parts of root of kudzu vine, 8 parts of Chinese yam, 10 parts of ginkgo biloba, 16 parts of corn silk, 16 parts of gynostemma pentaphylla, 7 parts of pseudo-ginseng, 35 parts of haw, 3 parts of perilla, 2 parts of apocynum venetum, 5 parts of wild chrysanthemum flower, 2 parts of prunella vulgaris, 17 parts of uncaria, 16 parts of wolfberry, 3 parts of concha haliotidis, 6 parts of eucommia, 10 parts of raw oyster shell, 15 parts of white peony root, 15 parts of achyranthes root, 3 parts of lotus plumule, 10 parts of Poria cocos, 10 parts of rhizoma alismatis and 10 parts of rhizoma gastrodiae. Symptoms of a patient can be alleviated within a short period of time after the capsule is taken. The capsule has effects of reducing blood pressure and blood lipid. Curative effect is stable; drug effect is definite; and the technology is feasible. The capsule has little side effect if a patient takes the capsule for a long time. After drug discontinuance, hypertension is not easy to recur. Costof the capsule is low.

Description

One treats hypertensive capsule

Technical field

The present invention relates to a kind of Chinese medicinal capsule, particularly one treats hypertensive capsule, belongs to pure technical field of Chinese medicines.

Background technology

Hypertension has onset concealment, and PD is slow.Usual earlier, without any symptom, occasionally has headache and dizzy, cardiopalmus, absent minded, hypomnesis, fatigue and weak, the easily symptom such as irritated; A lot of patient finds that blood pressure raises when being only and having a medical check-up.Hypertension can cause the target organ damages such as brain, the heart, kidney, peripheral vessels.The Therapeutic Method not getting instant result at present and cure completely.Have many antihypertensive drugs can control blood pressure clinically to raise, but Western medicine side effect is large, long-term taking can cause the damage to liver, kidney; The slow curative effect of existing Chinese medicine, DeGrain; They all easily rebound after drug withdrawal.

Summary of the invention

The object of the present invention is to provide one to treat hypertensive capsule, patient can by making symptom be eased in the short time after taking this medicine, has to reduce blood pressure and blood fat easily rebounds, low cost.

Technical scheme of the present invention is: one treats hypertensive capsule, it is characterized in that: it is formed by following weight parts raw material of Chinese medicine Pharmaceutical formulations: the Radix Astragali 2 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Puerariae 6 parts, Rhizoma Dioscoreae 8 parts, Folium Ginkgo 10 parts, Stigma Maydis 16 parts, Herb Gynostemmae Pentaphylli 16 parts, Radix Notoginseng 7 parts, Fructus Crataegi 35 parts, Folium Perillae 3 parts, Herba Apocyni veneti 2 parts, Flos Chrysanthemi Indici 5 parts, Spica Prunellae 2 parts, Ramulus Uncariae Cum Uncis 17 parts, Fructus Lycii 16 parts, Concha Haliotidis 3 parts, the Cortex Eucommiae 6 parts, Concha Ostreae 10 parts, the Radix Paeoniae Alba 15 parts, Radix Achyranthis Bidentatae 15 parts, Plumula Nelumbinis 3 parts, 10 parts, Poria, Rhizoma Alismatis 10 parts and 10 parts, Rhizoma Gastrodiae.

2, a kind of preparation method for the treatment of hypertensive capsule according to claim 1, is characterized in that: the method comprises the steps:

1), raw material is taken by following weight parts:

Get the Radix Astragali 2 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Puerariae 6 parts, Rhizoma Dioscoreae 8 parts, Folium Ginkgo 10 parts, Stigma Maydis 16 parts, Herb Gynostemmae Pentaphylli 16 parts, Radix Notoginseng 7 parts, Fructus Crataegi 35 parts, Folium Perillae 3 parts, Herba Apocyni veneti 2 parts, Flos Chrysanthemi Indici 5 parts, Spica Prunellae 2 parts, Ramulus Uncariae Cum Uncis 17 parts, Fructus Lycii 16 parts, Concha Haliotidis 3 parts, the Cortex Eucommiae 6 parts, Concha Ostreae 10 parts, the Radix Paeoniae Alba 15 parts, Radix Achyranthis Bidentatae 15 parts, Plumula Nelumbinis 3 parts, 10 parts, Poria, Rhizoma Alismatis 10 parts and 10 parts, Rhizoma Gastrodiae;

2) this few taste medical material of the Radix Astragali of above-mentioned weight portion, Radix Salviae Miltiorrhizae, Radix Puerariae, Rhizoma Dioscoreae, Folium Ginkgo, Stigma Maydis, Radix Notoginseng, Folium Perillae, Herba Apocyni veneti, Flos Chrysanthemi Indici, Spica Prunellae, Ramulus Uncariae Cum Uncis, Fructus Lycii, Concha Haliotidis, the Cortex Eucommiae, Concha Ostreae, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Plumula Nelumbinis, Poria, Rhizoma Alismatis and Rhizoma Gastrodiae, is got, decoct with water twice, add water 10 times amount for the first time, decocts 3 hours; Second time adds water 8 times amount, decocts 2 hours, merges twice decoction liquor, filtration, filtrate reduced in volume, and to temperature 60 DEG C time, relative density is the thick paste of 1.20-1.25%; By thick paste 75-85 DEG C drying, dry cream carries out pulverizing 100 mesh sieves, and get dry extract powder;

3) get the Fructus Crataegi of above-mentioned weight portion, Herb Gynostemmae Pentaphylli two taste medical material, decoct with water twice, add water 10 times amount for the first time, decocts 3 hours; Second time adds water 8 times amount, decocts 2 hours, merges twice decoction liquor, filtration, filtrate reduced in volume, and to temperature 60 DEG C time, relative density is the thick paste of 1.20-1.25%; By thick paste 75-85 DEG C drying, dry cream carries out pulverizing 100 mesh sieves, and get dry extract powder;

4) by step 2) dried cream powder mix according to equal increments method with the dried cream powder of step 3), obtain mixture, incapsulate, get product.

Advantage of the present invention: Ramulus Uncariae Cum Uncis: sweet in the mouth cold nature, tool heat clearing away suppressing the hyperactive liver, the effect of endogenous wind stopping relieving convulsion.The Cortex Eucommiae: have invigorating the liver and kidney, bone and muscle strengthening, antiabortive antihypertensive effect, can blood pressure lowering with compatibilities such as Concha Haliotidis, Spica Prunellae, the Radix Paeoniae Albas, and to people's blood pressure lowering of body void without cold and cool fraud.Herba Apocyni veneti: lightly seasoned adstringency is cool, has suppressing the hyperactive liver blood pressure lowering, clearing away heat and promoting diuresis effect, coordinates Spica Prunellae, Flos Chrysanthemi Indici, Ramulus Uncariae Cum Uncis with decocting.Flos Chrysanthemi Indici, heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.Fructus Lycii: nourishing the liver and kidney, replenishing vital essence to improve eyesight; Fructus Crataegi has increase myotility, and increase cardiac output, the effect of decreasing heart rate, has more lasting hypotensive effect, has the effect for reducing fat comparatively affirmed; Folium Perillae, relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, solving toxin of fish and crab.Spica Prunellae: acrid in the mouth bitterness is trembled with fear, and has liver heat removing, eliminating stagnation, reduces phlegm, hypotensive effect; The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation; Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, promote the production of body fluidlung benefiting, the kidney invigorating arresting seminal emission; Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from bloodeliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind; Radix Notoginseng removing stasis to stop bleeding, analgesic therapy of invigorating blood circulation.The kind hemostasis of merit, again can blood stasis dispersing and fresh blood promoting, and have hemostasis not stay the stasis of blood, positive feature is not hindered in blood stasis dispelling; Radix Puerariae relieves inflammation or internal heat, toxin expelling, blood fat reducing, blood pressure lowering, cholesterol reducing, blood sugar lowering, prevent arteriosclerosis.

In sum, feature of the present invention is blood circulation promoting and blood stasis dispelling, and circulation of qi promoting is stopped blooding, stasis-dispelling and pain-killing; There is hypertension and hyperlipemia, improve microcirculation, atherosclerosis, inhibition thrombosis.Patient can by making symptom be eased in the short time after taking this medicine, and have and reduce blood pressure and its stable curative effect of effect of blood fat, drug effect is definite, feasible process.During patient's long-term taking, side effect is little, is not easy bounce-back, low cost after drug withdrawal.

Detailed description of the invention

Clearly the present invention can be described further below by the specific embodiment provided, but not as a limitation of the invention.

A kind of preparation method for the treatment of hypertensive capsule comprises the steps:

1), raw material is taken by following weight:

Get Radix Astragali 2g, Radix Salviae Miltiorrhizae 20g, Radix Puerariae 6g, Rhizoma Dioscoreae 8g, Folium Ginkgo 10g, Stigma Maydis 16g, Herb Gynostemmae Pentaphylli 16g, Radix Notoginseng 7g, Fructus Crataegi 35g, Folium Perillae 3g, Herba Apocyni veneti 2g, Flos Chrysanthemi Indici 5g, Spica Prunellae 2g, Ramulus Uncariae Cum Uncis 17g, Fructus Lycii 16g, Concha Haliotidis 3g, Cortex Eucommiae 6g, Concha Ostreae 10g, Radix Paeoniae Alba 15g, Radix Achyranthis Bidentatae 15g, Plumula Nelumbinis 3g, Poria 10g, Rhizoma Alismatis 10g and Rhizoma Gastrodiae 10g;

2) this few taste medical material of the Radix Astragali of above-mentioned weight, Radix Salviae Miltiorrhizae, Radix Puerariae, Rhizoma Dioscoreae, Folium Ginkgo, Stigma Maydis, Radix Notoginseng, Folium Perillae, Herba Apocyni veneti, Flos Chrysanthemi Indici, Spica Prunellae, Ramulus Uncariae Cum Uncis, Fructus Lycii, Concha Haliotidis, the Cortex Eucommiae, Concha Ostreae, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Plumula Nelumbinis, Poria, Rhizoma Alismatis and Rhizoma Gastrodiae, is got, decoct with water twice, add water 10 times amount for the first time, decocts 3 hours; Second time adds water 8 times amount, decocts 2 hours, merges twice decoction liquor, filtration, filtrate reduced in volume, and to temperature 60 DEG C time, relative density is the thick paste of 1.20-1.25%; By thick paste 75-85 DEG C drying, dry cream carries out pulverizing 100 mesh sieves, and get dry extract powder;

3) get the Fructus Crataegi of above-mentioned weight, Herb Gynostemmae Pentaphylli two taste medical material, decoct with water twice, add water 10 times amount for the first time, decocts 3 hours; Second time adds water 8 times amount, decocts 2 hours, merges twice decoction liquor, filtration, filtrate reduced in volume, and to temperature 60 DEG C time, relative density is the thick paste of 1.20-1.25%; By thick paste 75-85 DEG C drying, dry cream carries out pulverizing 100 mesh sieves, and get dry extract powder;

4) by step 2) dried cream powder mix according to equal increments method with the dried cream powder of step 3), obtain mixture, incapsulate, get product.

Using method: every day 3 times, each 2.

In order to show the therapeutic effect of capsule of the present invention, invention has been clinical trial.

A kind of clinical trial for the treatment of hypertensive capsule proposed by the invention is as follows:

Select age 48-58 year patient 80 example, 53 years old mean age ,-1 year April of the course of disease, average course of disease 7 months.Patient did not accept other treatment before this treatment, surveyed its blood pressure and all exceeded normal value.Within 28 days, be a course for the treatment of, after 28 days, carry out symptom score.In 80 routine patients, 20 examples (being called treatment group) adopt the capsule of the embodiment of the present invention; 20 examples (being called contrast A group) adopt Benazepril hydrochloride contents in tablets; 20 examples (being called contrast B group) adopt capsule for clearing liver and reducing blood pressure; 20 examples (being called contrast C group) do not carry out Drug therapy.Period patient gives up smoking, and avoids zest environment, is careful in one's diet and has a rest.

Employing Benazepril hydrochloride contents in tablets using method is: once a day, each a slice; Adopt identical with capsule Example of the present invention of the using method of capsule for clearing liver and reducing blood pressure.

therapeutic outcome:

the pressure value that hypertensive diagnosis is measured according to clinic, adopts approved mercury column or electric sphygmomanometer, upper arm brachial artery position blood pressure when measuring quiet rest seat.Also should measure horizontal position and erect position blood pressure if desired.The effective criterion of hypertension: be normal value 130/85mmHg during measurement.After drug withdrawal, bounce-back standard is: when measuring after referring to drug withdrawal, blood pressure exceeds normal value 130/85mmHg.

Treat after 28 days, therapeutic effect compares in table 1.

Table 1 embodiment of the present invention treats effectiveness comparison after 28 days

From table 1, the treatment group effective percentage of the capsule adopting the present invention made is apparently higher than contrast B and C group, and after drug withdrawal, rebound rate is also starkly lower than contrast B and C group, and the number of cases that rebounds after treatment group drug withdrawal only has an example; Although the bounce-back number of cases of contrast A group effective percentage higher than other several groups but after patient's drug withdrawal is routine up to 11, apparently higher than treatment group.It is good that result shows to use the whole structure of the treatment for the treatment of group, is not easy bounce-back after drug withdrawal.

Claims (2)

1. treat a hypertensive capsule, it is characterized in that: it is formed by following weight parts raw material of Chinese medicine Pharmaceutical formulations: the Radix Astragali 2 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Puerariae 6 parts, Rhizoma Dioscoreae 8 parts, Folium Ginkgo 10 parts, Stigma Maydis 16 parts, Herb Gynostemmae Pentaphylli 16 parts, Radix Notoginseng 7 parts, Fructus Crataegi 35 parts, Folium Perillae 3 parts, Herba Apocyni veneti 2 parts, Flos Chrysanthemi Indici 5 parts, Spica Prunellae 2 parts, Ramulus Uncariae Cum Uncis 17 parts, Fructus Lycii 16 parts, Concha Haliotidis 3 parts, the Cortex Eucommiae 6 parts, Concha Ostreae 10 parts, the Radix Paeoniae Alba 15 parts, Radix Achyranthis Bidentatae 15 parts, Plumula Nelumbinis 3 parts, 10 parts, Poria, Rhizoma Alismatis 10 parts and 10 parts, Rhizoma Gastrodiae.

2. a kind of preparation method for the treatment of hypertensive capsule according to claim 1, is characterized in that: the method comprises the steps:

1), raw material is taken by following weight parts:

Get the Radix Astragali 2 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Puerariae 6 parts, Rhizoma Dioscoreae 8 parts, Folium Ginkgo 10 parts, Stigma Maydis 16 parts, Herb Gynostemmae Pentaphylli 16 parts, Radix Notoginseng 7 parts, Fructus Crataegi 35 parts, Folium Perillae 3 parts, Herba Apocyni veneti 2 parts, Flos Chrysanthemi Indici 5 parts, Spica Prunellae 2 parts, Ramulus Uncariae Cum Uncis 17 parts, Fructus Lycii 16 parts, Concha Haliotidis 3 parts, the Cortex Eucommiae 6 parts, Concha Ostreae 10 parts, the Radix Paeoniae Alba 15 parts, Radix Achyranthis Bidentatae 15 parts, Plumula Nelumbinis 3 parts, 10 parts, Poria, Rhizoma Alismatis 10 parts and 10 parts, Rhizoma Gastrodiae;

2) this few taste medical material of the Radix Astragali of above-mentioned weight portion, Radix Salviae Miltiorrhizae, Radix Puerariae, Rhizoma Dioscoreae, Folium Ginkgo, Stigma Maydis, Radix Notoginseng, Folium Perillae, Herba Apocyni veneti, Flos Chrysanthemi Indici, Spica Prunellae, Ramulus Uncariae Cum Uncis, Fructus Lycii, Concha Haliotidis, the Cortex Eucommiae, Concha Ostreae, the Radix Paeoniae Alba, Radix Achyranthis Bidentatae, Plumula Nelumbinis, Poria, Rhizoma Alismatis and Rhizoma Gastrodiae, is got, decoct with water twice, add water 10 times amount for the first time, decocts 3 hours; Second time adds water 8 times amount, decocts 2 hours, merges twice decoction liquor, filtration, filtrate reduced in volume, and to temperature 60 DEG C time, relative density is the thick paste of 1.20-1.25%; By thick paste 75-85 DEG C drying, dry cream carries out pulverizing 100 mesh sieves, and get dry extract powder;

3) get the Fructus Crataegi of above-mentioned weight portion, Herb Gynostemmae Pentaphylli two taste medical material, decoct with water twice, add water 10 times amount for the first time, decocts 3 hours; Second time adds water 8 times amount, decocts 2 hours, merges twice decoction liquor, filtration, filtrate reduced in volume, and to temperature 60 DEG C time, relative density is the thick paste of 1.20-1.25%; By thick paste 75-85 DEG C drying, dry cream carries out pulverizing 100 mesh sieves, and get dry extract powder;

4) by step 2) dried cream powder mix according to equal increments method with the dried cream powder of step 3), obtain mixture, incapsulate, get product.