CN104587251A - Traditional Chinese medicine capsules for treating gout and preparation method thereof - Google Patents
Traditional Chinese medicine capsules for treating gout and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to traditional Chinese medicine capsules for treating gout and a preparation method thereof. The traditional Chinese medicine capsules are prepared from the following traditional Chinese medicine raw materials in parts by weight: 28-30 parts of perilla stem, 20-23 parts of dried leech, 20-25 parts of cassia seed, 28-30 parts of tuberculate speranskia herb, 15-17 parts of corn stigma, 18-20 parts of Indian buead, 5-7 parts of baikal skullcap root, 7-11 parts of radish seed, 7-11 parts of white ramping fumitory, 5-7 parts of panax notoginseng, 5-7 parts of manchurian wildginger, 7-11 parts of kusnezoff monkshood root, 20-25 parts of wolfberry, 10-13 parts of silkworm excrement, 11-15 parts of Sichuan cassia twig, 2-4 parts of jackinthepulpit tuber, 11-15 parts of root of doubleteeth pubescent angelica, 8-12 parts of common dysosmatis rhizome and root and 8-12 parts of Chinese yam. The traditional Chinese medicine capsules disclosed by the invention have the advantages that all adopted traditional Chinese medicines can meet the regulations of Pharmacopoeia of the people's Republic of China, so that the traditional Chinese medicine capsules are safe and reliable in medicines, and can be used for warming channels and expelling cold, promoting qi and activating blood circulation, and tonifying the kidneys and arresting seminal emission so as to ensure that gout symptoms can be improved, disease progression can be controlled, and the immunity of patients can be enhanced; and moreover, the traditional Chinese medicine capsules can be used for harmonizing the stomach and dissolving turbidity, stopping bleeding and dispersing blood stasis, and removing swelling and easing pain, and can be used for greatly alleviating the pain of the patients and preventing complications.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese medicinal capsule for the treatment of gout and preparation method thereof.
Background technology
Gout is the crystal dependency arthrosis caused by monosodium urate mineralization, directly related with the hyperuricemia caused by purine metabolic disturbance and underexcretion, refer in particular to acute characteristic arthritis and chronic gout stone disease, mainly comprising acute attack arthritis, tophus formation, tophaceous chronic arthritis, urate nephropathy and uric acid lithangiuria, can there is joint deformity and renal insufficiency in severe one.At present, gout develops into present commonly encountered diseases by rare disease previously, closely related with people's dietary habit, lifestyle change.Gout is more common in middle-aged male, and women only accounts for 5%, mainly postmenopausal women, and gout has rejuvenation trend.The natural history of gout can be divided into the fourth phase, i.e. asymptomatic hyperuricemia phase, acute stage, intermission, chronic phase.
Gout can be divided into constitutional and the large class of Secondary cases two according to cause of disease difference.Primary gout refers on the basis getting rid of other diseases, caused by congenital purine metabolic disturbance and uric acid excretion disorder; Secondary gout refers to be secondary to uricopoiesis caused by underexcretion, myeloproliferative disease and chemotherapy of tumors caused by kidney disease or some drugs to be increased.Gout is many with multiple complications such as abdominal obesity, hyperlipemia, hypertension, type 2 diabetes mellitus and cardiovascular diseasess, therefore not only to pay attention to the active treatment of acute attack stage, also paracmastic treatment to be paid attention to, carry out well and can greatly reduce gouty arthritis outbreak, delay disease progression, prevent complication.
In treatment, the pain relieving of Western medicine drug many employings colchicine, allopurinol suppresses uricopoiesis, and probenecid increases urate excretion.Western medicine is taken in process and is produced multiple side effect, comprises the gastrointestinal reactions such as nausea,vomiting,diarrhea, reduces leukocyte, infringement hepatic and renal function etc.Traditional Chinese medical herbal treatment aspect, medicament categories is few, mainly contains gout stator, heat clearing away arthralgia aggravated by cold cream, LIUSHEN WAN etc., can alleviate the clinical symptoms such as ailing, but effect is not clearly.
Summary of the invention
According to the deficiencies in the prior art, the invention provides and a kind ofly effectively can treat the pure Chinese medicine formula of gout and the preparation method of capsule thereof, compensate for the deficiency that Western medicine can produce multiple side effect over the course for the treatment of, simultaneously also for Chinese traditional treatment provides a kind of instant effect, good recipe that relapse rate is low, reach the object for the treatment of both the principal and secondary aspects of a disease.
A kind of Chinese medicinal capsule for the treatment of gout disclosed in this invention, formulated by the raw material of Chinese medicine of following parts by weight: Caulis Perillae 28-30 part, solid carbon dioxide trematodiasis 20-23 part, Semen Cassiae 20-25 part, Herba speranskiae tuberculatae 28-30 part, Stigma Maydis 15-17 part, Poria 18-20 part, Radix Scutellariae 5-7 part, Semen Raphani 7-11 part, Rhizoma Corydalis entangles 7-11 part, Radix Notoginseng 5-7 part, Herba Asari 5-7 part, Radix Aconiti Kusnezoffii 7-11 part, Fructus Lycii 20-25 part, Bombyx mori L. 10-13 part, Ramulus Cinnamomi 11-15 part, Rhizoma Arisaematis 2-4 part, Radix Angelicae Pubescentis 11-15 part, Radix et Rhizoma Dysosmatis 8-12 part, Rhizoma Dioscoreae 8-12 part.
Treat a Chinese medicinal capsule for gout, preferably formulated by the raw material of Chinese medicine of following parts by weight: Caulis Perillae 29 parts, solid carbon dioxide trematodiasis 21 parts, Semen Cassiae 22 parts, Herba speranskiae tuberculatae 29 parts, Stigma Maydis 16 parts, 19 parts, Poria, Radix Scutellariae 6 parts, Semen Raphani 9 parts, Rhizoma Corydalis entangles 9 parts, Radix Notoginseng 6 parts, Herba Asari 6 parts, Radix Aconiti Kusnezoffii 9 parts, Fructus Lycii 22 parts, Bombyx mori L. 11 parts, Ramulus Cinnamomi 13 parts, Rhizoma Arisaematis 3 parts, Radix Angelicae Pubescentis 13 parts, Radix et Rhizoma Dysosmatis 10 parts, Rhizoma Dioscoreae 10 parts.
Treat a preparation method for the Chinese medicinal capsule of gout, step is as follows:
A, get Caulis Perillae, solid carbon dioxide trematodiasis, Semen Cassiae, Herba speranskiae tuberculatae, Poria, Radix Scutellariae, Semen Raphani and Radix et Rhizoma Dysosmatis mixing, add the water soaking 1.5 hours of 7 times amount, extracts the volatile oil of 3 hours, collect volatile oil, medicinal liquid filtration, medicinal residues are for subsequent use;
B, get surplus stock medical material and described step a medicinal residues mixing, add 75% ethanol, soak 1 hour, extract twice, each 1.5 hours, first time add 7 times amount, second time add 7 times amount, merge extractive liquid, filtration; To concentrate filtrate to when relative density is 80 DEG C 1.30, precipitate with ethanol twice, adjust concentration of alcohol to 75%, when to get supernatant concentration to relative density be 80 DEG C 1.30, obtain extractum;
C, get above-mentioned extractum, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil accounts for 3% of extractum and volatile oil gross mass, mixing, grinds 10 minutes with colloid mill, constantly stirs, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
Preferred version is as follows:
In described step a, the extraction of volatile oil adopts steam distillation or supercritical fluid extraction.
Extract in described step b and adopt membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
Instructions of taking: sooner or later respectively once, each 2, warm water takes.It within 10 days, is a course for the treatment of.
Pharmacology analysis:
Caulis Perillae: acrid in the mouth, warm in nature.Can regulating the flow of QI to ease the stomach, pain relieving.Cure mainly chest and diaphragm painful abdominal mass vexed, gastralgia, belch is vomitted.
Solid carbon dioxide trematodiasis: salty in the mouth, hardship, property is put down.Removing blood stasis, removing blood stasis.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.
Semen Cassiae: sweet in the mouth, hardship, salty, cold nature.Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
Herba speranskiae tuberculatae: acrid in the mouth, hardship, warm in nature.Expelling wind and removing dampness, removing toxic substances pain relieving.For rheumatic arthritis, sore swollen toxin is controlled in external.
Stigma Maydis: sweet in the mouth, light, property is put down.Return bladder, liver, gallbladder meridian.Function cures mainly inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice.
Poria: sweet in the mouth, light, property is put down, GUIXIN, lung, spleen, kidney channel.Function cures mainly promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.There is antioxidation, anti-aging, increase immunity, improve the effect of brain cell activity.Poria has stronger diuresis, can treat nephritis, heart failure edema.Also have sedation in addition, effective to neurasthenia.Lightly seasoned property is put down, kind benefiting QI and nourishing blood, and mind tranquilizing and the heart calming, relieves internal heat anticancer; Mild in medicine property and, dampness removing and do not hinder healthy energy, contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.; Can be relaxed gastrointestinal smooth muscle, the effects such as gastric acid secretion inhibiting, prevents hepatic necrosis, antibacterial.
Radix Scutellariae: bitter in the mouth, cold in nature, return lung, gallbladder, spleen, large intestine, small intestine meridian.Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.Function cures mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.
Semen Raphani: acrid in the mouth, sweet, property is put down, and returns spleen, stomach, lung meridian.Function helps digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly food stagnation to stagnate, abdominal distention, belch is had the hiccups, constipation, heavy after dysentery, and expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Rhizoma Corydalis is entangled: acrid in the mouth, hardship, warm in nature.Its tuber, containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., is invigorated blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature.Hemostasis dissipating blood stasis, subduing swelling and relieving pain, has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.Cure mainly spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast ventral spine pain, tumbling down swells and ache.
Herba Asari: property is pungent, taste temperature, returns lung, the heart, kidney channel.Function is dispeled the wind, cold expelling, and row water, has one's ideas straightened out.Cure mainly air-cooled headache, rheumatic arthralgia, toothache, nasal sinusitis, phlegm retention cough with dyspnea.Modern pharmacological research display Herba Asari analgesic activity is obvious.
Radix Aconiti Kusnezoffii: acrid in the mouth, hardship, hot in nature.Expelling wind and removing dampness, antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Fructus Lycii: sweet in the mouth, property is put down, and returns liver, kidney, lung meridian.Function the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the lung moistening and production of body fluid promoting.The treatment hepatic and renal YIN deficiency, essence and blood loses few, and weak idle dynamic, forgetful insomnia, soreness of waist and knee joint, impotence and seminal emission, vertigo and tinnitus, blurring of vision, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, cough due to consumptive disease etc.Modern pharmacological research is reported, Fructus Lycii have improve and immunity moderation function, antioxidation, defying age, protect the liver, promote body injury reparation, promote hemopoietic function, protection endocrinal glands, protection retina, enhancing resisting fatigue and the effect of hypoxia-bearing capability.Be usually used in treatment senile dementia caused by liver and kidney deficiency disease, doublely control cough due to consumptive disease, the vexed disease such as to quench one's thirst.
Bombyx mori L.: sweet in the mouth, pungent, warm in nature.Expelling wind and removing dampness, regulating the function of the stomach to resolve the turbidity, promoting blood circulation to restore menstrual flow.Function cures mainly main air pain of dampness syndrome, and limbs are unsuccessful, rubella pruritus, convulsion of vomiting and diarrhoea, amenorrhea, metrorrhagia.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.Dispelling cold by warming the meridian, promoting flow of QI and blood, pain relieving.For being affected by the cold, stomach abdomen cold type of pain, dysmenorrhea, Fengshi Guanjie pain; Traumatic injury is controlled in external, fracture.
Rhizoma Arisaematis: bitter in the mouth, pungent, warm in nature.Return lung, liver, spleen channel.Have expelling wind and relieving convulsion, the function of dissipating phlegm and resolving masses.Cure mainly the heap soil or fertilizer over and around the roots of middle wind-phlegm, facial hemiparalysis, hemiplegia, paralysis of the limbs, dizziness due to wind-phlegm, insane spare time, infantile convulsion, tetanus, cough ant phlegm, carbuncle, scrofula, traumatic injury paralysis, venom.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature.Return liver, kidney, urinary bladder channel.Function cures mainly expelling wind and dampness, dispersing cold for relieving pain; Cure mainly anemofrigid-damp arthralgia; Lumbocrural pain, few cloudy volt wind headache, headache toothache.Modern pharmacology proves, Radix Angelicae Pubescentis has good analgesia, calmness and antiinflammatory action.
Radix et Rhizoma Dysosmatis: sweet in the mouth, hardship, cool in nature.Heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.Cure mainly venom, traumatic injury; Worm venom is controlled in external, and carbuncle furuncle swells, lymphadenitis, parotitis, breast carcinoma.
Rhizoma Dioscoreae: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.Can spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
The invention has the advantages that used Chinese medicine meets Pharmacopoeia of People's Republic of China regulation, safety of medicine is reliable, can dispelling cold by warming the meridian, promoting flow of QI and blood, the kidney invigorating arresting seminal emission, thus improve gout symptom, symptom management develops, and strengthens patient immunity, and can regulating the function of the stomach to resolve the turbidity, hemostasis dissipating blood stasis, subduing swelling and relieving pain, greatly alleviate patient's misery, prevent complication.
Outcome measure:
Effective: gout symptom is clearly better, arthralgia and ulcer skin lesion obviously alleviate or disappear, and symptom management continues development.
Effective: gout symptom is eased, and arthralgia alleviates, the remission of ulcer skin lesion.
Invalid: gout symptom is unchanged, arthralgia and ulcer skin lesion area increase or new disease appears in other positions.
Therapeutic outcome: treat 172 patient with gout, respectively takes two sooner or later.It within 10 days, is a course for the treatment of.After using 3 course for the treatment of Chinese medicines of the present invention, effective 161 examples, account for 93.61%, and effective 10 examples, account for 5.81%, and invalid 1 example, account for 0.58%, overall efficiency is 99.42%.As can be seen here, the treatment of the present invention to gout has good effect.
Attached several routine case is described further:
Case 1:
In the summer, man, 50 years old, patient often went on business, and drank frequent.Occurring finger, toes arthralgia, is very with hypnalgia, right finger anchylosis ulceration.Once took allopurinol, rosickyite acid etc., the state of an illness takes a turn for the better to some extent, but withdraws because having a stomachache discomfort.To our hospital afterwards, be diagnosed as gout, after taking 2 courses for the treatment of of capsule of the present invention, pain relief, the secretions at ulceration place reduces to some extent, toes swell and ache and subtract clearly, after continuing to take 2 courses for the treatment of, and the above transference cure of patient, blood uric acid is close to normal, patient continues to strengthen a course for the treatment of, follows up a case by regular visits to 1 year, does not recur.
Case 2:
Poplar, man, 20 years old, peasant.Patient is after once drinking, and happen suddenly left instep, and thumb swells and ache, and has difficulty in going to sleep, the scorching hot redness in local.After antiinflammatory paroxysmal pain medicine is taken in locality, pain relief after a week.After, after drinking whenever or catching a cold, i.e. easily outbreak, shows effect whenever, certainly takes the medicines such as prednisone.Rear outbreak causes left foot local red and swollen heat pain, and function limitation, comes my institute and be diagnosed as gout, then give capsule of the present invention, and after 2 courses for the treatment of, transference cure, walking freely, without walking lamely, is discharged from hospitals upon recovery after 3 courses for the treatment of.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail, but the present invention is not limited to specific embodiment.
Embodiment 1:
Treat a Chinese medicinal capsule for gout, formulated by the raw material of Chinese medicine of following parts by weight: Caulis Perillae 28 parts, solid carbon dioxide trematodiasis 23 parts, Semen Cassiae 20 parts, Herba speranskiae tuberculatae 30 parts, Stigma Maydis 15 parts, 20 parts, Poria, Radix Scutellariae 5 parts, Semen Raphani 11 parts, Rhizoma Corydalis entangles 7 parts, Radix Notoginseng 7 parts, Herba Asari 5 parts, Radix Aconiti Kusnezoffii 11 parts, Fructus Lycii 20 parts, Bombyx mori L. 13 parts, Ramulus Cinnamomi 11 parts, Rhizoma Arisaematis 4 parts, Radix Angelicae Pubescentis 11 parts, Radix et Rhizoma Dysosmatis 12 parts, Rhizoma Dioscoreae 8 parts.
Embodiment 2:
Treat a Chinese medicinal capsule for gout, formulated by the raw material of Chinese medicine of following parts by weight: Caulis Perillae 30 parts, solid carbon dioxide trematodiasis 20 parts, Semen Cassiae 25 parts, Herba speranskiae tuberculatae 28 parts, Stigma Maydis 17 parts, 18 parts, Poria, Radix Scutellariae 7 parts, Semen Raphani 7 parts, Rhizoma Corydalis entangles 11 parts, Radix Notoginseng 5 parts, Herba Asari 7 parts, Radix Aconiti Kusnezoffii 7 parts, Fructus Lycii 25 parts, Bombyx mori L. 10 parts, Ramulus Cinnamomi 15 parts, Rhizoma Arisaematis 2 parts, Radix Angelicae Pubescentis 15 parts, Radix et Rhizoma Dysosmatis 8 parts, Rhizoma Dioscoreae 12 parts.
Embodiment 3:
Treat a Chinese medicinal capsule for gout, formulated by the raw material of Chinese medicine of following parts by weight: Caulis Perillae 29 parts, solid carbon dioxide trematodiasis 21 parts, Semen Cassiae 22 parts, Herba speranskiae tuberculatae 29 parts, Stigma Maydis 16 parts, 19 parts, Poria, Radix Scutellariae 6 parts, Semen Raphani 9 parts, Rhizoma Corydalis entangles 9 parts, Radix Notoginseng 6 parts, Herba Asari 6 parts, Radix Aconiti Kusnezoffii 9 parts, Fructus Lycii 22 parts, Bombyx mori L. 11 parts, Ramulus Cinnamomi 13 parts, Rhizoma Arisaematis 3 parts, Radix Angelicae Pubescentis 13 parts, Radix et Rhizoma Dysosmatis 10 parts, Rhizoma Dioscoreae 10 parts.
Embodiment 4:
Treat a preparation method for the Chinese medicinal capsule of gout, step is as follows:
A, by deal described in embodiment 1, get Caulis Perillae, solid carbon dioxide trematodiasis, Semen Cassiae, Herba speranskiae tuberculatae, Poria, Radix Scutellariae, Semen Raphani and Radix et Rhizoma Dysosmatis mixing, add the water soaking 2 hours of 5 times amount, extracts the volatile oil of 2 hours, collect volatile oil, medicinal liquid filtration, medicinal residues are for subsequent use;
B, get surplus stock medical material and described step a medicinal residues mixing, add 90% ethanol, soak 0.5 hour, extract twice, each 2 hours, first time add 5 times amount, second time add 10 times amount, merge extractive liquid, filtration; To concentrate filtrate to when relative density is 80 DEG C 1.10, precipitate with ethanol twice, adjust concentration of alcohol to 90%, when to get supernatant concentration to relative density be 80 DEG C 1.10, obtain extractum;
C, get above-mentioned extractum, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil accounts for 5% of extractum and volatile oil gross mass, mixing, grinds 10 minutes with colloid mill, constantly stirs, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
In described step a, the extraction of volatile oil adopts extraction by steam distillation.
Extract in described step b and adopt membrane separation technique.
Instructions of taking: sooner or later respectively once, each 2, warm water takes.It within 10 days, is a course for the treatment of.
Embodiment 5:
Treat a preparation method for the Chinese medicinal capsule of gout, step is as follows:
A, by deal described in embodiment 2, get Caulis Perillae, solid carbon dioxide trematodiasis, Semen Cassiae, Herba speranskiae tuberculatae, Poria, Radix Scutellariae, Semen Raphani and Radix et Rhizoma Dysosmatis mixing, add the water soaking 1 hour of 10 times amount, extracts the volatile oil of 5 hours, collect volatile oil, medicinal liquid filtration, medicinal residues are for subsequent use;
B, get surplus stock medical material and described step a medicinal residues mixing, add 60% ethanol, soak 1.5 hours, extract twice, each 1 hour, first time add 10 times amount, second time add 5 times amount, merge extractive liquid, filtration; To concentrate filtrate to when relative density is 80 DEG C 1.50, precipitate with ethanol twice, adjust concentration of alcohol to 60%, when to get supernatant concentration to relative density be 80 DEG C 1.50, obtain extractum;
C, get above-mentioned extractum, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil accounts for 2% of extractum and volatile oil gross mass, mixing, grinds 10 minutes with colloid mill, constantly stirs, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
In described step a, the extraction of volatile oil adopts supercritical fluid extraction.
Extract in described step b and adopt macroporous resin method.
Instructions of taking: sooner or later respectively once, each 2, warm water takes.It within 10 days, is a course for the treatment of.
Embodiment 6:
Treat a preparation method for the Chinese medicinal capsule of gout, step is as follows:
A, by deal described in embodiment 3, get Caulis Perillae, solid carbon dioxide trematodiasis, Semen Cassiae, Herba speranskiae tuberculatae, Poria, Radix Scutellariae, Semen Raphani and Radix et Rhizoma Dysosmatis mixing, add the water soaking 1.5 hours of 7 times amount, extracts the volatile oil of 3 hours, collect volatile oil, medicinal liquid filtration, medicinal residues are for subsequent use;
B, get surplus stock medical material and described step a medicinal residues mixing, add 75% ethanol, soak 1 hour, extract twice, each 1.5 hours, first time add 7 times amount, second time add 7 times amount, merge extractive liquid, filtration; To concentrate filtrate to when relative density is 80 DEG C 1.30, precipitate with ethanol twice, adjust concentration of alcohol to 75%, when to get supernatant concentration to relative density be 80 DEG C 1.30, obtain extractum;
C, get above-mentioned extractum, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil accounts for 3% of extractum and volatile oil gross mass, mixing, grinds 10 minutes with colloid mill, constantly stirs, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
In described step a, the extraction of volatile oil adopts extraction by steam distillation.
Extract in described step b and adopt high speed centrifugation method.
Instructions of taking: sooner or later respectively once, each 2, warm water takes.It within 10 days, is a course for the treatment of.
Below the present invention be described in detail, the above, be only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modify, all should still belong in covering scope of the present invention.
Claims (5)
1. treat the Chinese medicinal capsule of gout for one kind, it is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Caulis Perillae 28-30 part, solid carbon dioxide trematodiasis 20-23 part, Semen Cassiae 20-25 part, Herba speranskiae tuberculatae 28-30 part, Stigma Maydis 15-17 part, Poria 18-20 part, Radix Scutellariae 5-7 part, Semen Raphani 7-11 part, Rhizoma Corydalis entangles 7-11 part, Radix Notoginseng 5-7 part, Herba Asari 5-7 part, Radix Aconiti Kusnezoffii 7-11 part, Fructus Lycii 20-25 part, Bombyx mori L. 10-13 part, Ramulus Cinnamomi 11-15 part, Rhizoma Arisaematis 2-4 part, Radix Angelicae Pubescentis 11-15 part, Radix et Rhizoma Dysosmatis 8-12 part, Rhizoma Dioscoreae 8-12 part.
2. a kind of Chinese medicinal capsule for the treatment of gout according to claim 1, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Caulis Perillae 29 parts, solid carbon dioxide trematodiasis 21 parts, Semen Cassiae 22 parts, Herba speranskiae tuberculatae 29 parts, Stigma Maydis 16 parts, 19 parts, Poria, Radix Scutellariae 6 parts, Semen Raphani 9 parts, Rhizoma Corydalis entangles 9 parts, Radix Notoginseng 6 parts, Herba Asari 6 parts, Radix Aconiti Kusnezoffii 9 parts, Fructus Lycii 22 parts, Bombyx mori L. 11 parts, Ramulus Cinnamomi 13 parts, Rhizoma Arisaematis 3 parts, Radix Angelicae Pubescentis 13 parts, Radix et Rhizoma Dysosmatis 10 parts, Rhizoma Dioscoreae 10 parts.
3. a preparation method for the Chinese medicinal capsule for the treatment of gout according to claim 1, is characterized in that preparation method comprises the following steps:
A, get Caulis Perillae, solid carbon dioxide trematodiasis, Semen Cassiae, Herba speranskiae tuberculatae, Poria, Radix Scutellariae, Semen Raphani and Radix et Rhizoma Dysosmatis mixing, add the water soaking 1-2 hour of 5-10 times amount, extract the volatile oil of 2-5 hour, collect volatile oil, medicinal liquid filtration, medicinal residues are for subsequent use;
B, get surplus stock medical material and described step a medicinal residues mixing, add 60%-90% ethanol, soak 0.5-1.5 hour, extract twice, each 1-2 hour, first time add 5-10 times amount, second time add 5-10 times amount, merge extractive liquid, filter; Concentrate filtrate to 1.10-1.50 when relative density is 80 DEG C, precipitate with ethanol twice, adjust concentration of alcohol to 60%-90%, 1.10-1.50 when to get supernatant concentration to relative density be 80 DEG C, obtains extractum;
C, get above-mentioned extractum, add volatile oil and vegetable oil that step a obtains, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mixing, grinds 10 minutes with colloid mill, constantly stirs, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.
4. a kind of preparation method for the treatment of the Chinese medicinal capsule of gout according to claim 3, is characterized in that: in described step a, the extraction of volatile oil adopts steam distillation or supercritical fluid extraction.
5. a kind of preparation method for the treatment of the Chinese medicinal capsule of gout according to claim 3, is characterized in that: extract in described step b and adopt membrane separation technique, ultrafiltration, precipitate with ethanol, high speed centrifugation or macroporous resin method.
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| CN108669142A (en) * | 2018-06-11 | 2018-10-19 | 王哲 | One kind removing gout curing rheumatism herbal cuisine pellet shortcake and preparation method thereof |
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| CN101406584A (en) * | 2008-11-27 | 2009-04-15 | 蒋月芝 | Agent for treating gout |
| CN102526238A (en) * | 2012-02-09 | 2012-07-04 | 中国中医科学院中药研究所 | Chinese medicinal composition for preventing and treating rheumatoid arthritis |
| CN103933224A (en) * | 2014-04-30 | 2014-07-23 | 周晓明 | Traditional Chinese medicine composition for treating gout |
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| CN101406584A (en) * | 2008-11-27 | 2009-04-15 | 蒋月芝 | Agent for treating gout |
| CN102526238A (en) * | 2012-02-09 | 2012-07-04 | 中国中医科学院中药研究所 | Chinese medicinal composition for preventing and treating rheumatoid arthritis |
| CN103933224A (en) * | 2014-04-30 | 2014-07-23 | 周晓明 | Traditional Chinese medicine composition for treating gout |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108669142A (en) * | 2018-06-11 | 2018-10-19 | 王哲 | One kind removing gout curing rheumatism herbal cuisine pellet shortcake and preparation method thereof |
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| CN104587251B (en) | 2019-01-25 |
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