WO2017101151A1

WO2017101151A1 - Gout treating traditional chinese medicine composition and preparation method therefor

Info

Publication number: WO2017101151A1
Application number: PCT/CN2015/098982
Authority: WO
Inventors: 华坚
Original assignee: 华坚
Priority date: 2015-12-14
Filing date: 2015-12-25
Publication date: 2017-06-22
Also published as: CN105288518A

Abstract

Provided are a traditional Chinese medicine composition for treating gout and a preparation method therefor.The Chinese medicine composition is prepared by drying, grinding the following raw materials by part of weight: 20-40 parts of kadsura pepper stem, 2-7 parts of Japanese climbing fern spore, 8-15 parts of Christina loosestrife, 8-15 parts of amur cork-tree leaf, 8-15 parts of officinal magnolia bark, 8-15 parts of black beans, 2-7 parts of poria cocos, 2-7 parts of Chinese magnoliavine fruit, 2-7 parts of licorice, 2-7 parts of Chinese pulsatilla root, 2-7 parts of magnolia obavata, 2-7 parts of zedoray rhizome, 2-7 parts of tortoise plastron, 2-7 parts of oriental waterplantain rhizome, 8-15 parts of dried tangerine peel, 2-7 parts of inner membrane of chicken gizzard, 2-7 parts of tendrilleaf fritillary bulb, 2-7 parts of villous amomum fruit, 2-7 parts of dendrobium, 2-7parts of myrrh, and 8-15 parts of suberect spatholobus stem, and decocting them in water.

Description

Traditional Chinese medicine composition for treating gout and preparation method thereof

Technical field

The present invention relates to a traditional Chinese medicine composition.

Background technique

Gout is a crystal-associated joint disease caused by deposition of monosodium urate (MSU), which is directly related to hyperuricemia caused by a decrease in sputum metabolism and/or uric acid excretion, especially acute characteristic arthritis. Chronic tophi stone disease. With the development of society, the pace of life is accelerating, the pressure of life is increasing, and the diet structure is changing, the number of patients with gout is also increasing. Gout is more common in middle-aged men, and women account for only 5%, mainly postmenopausal women. At present, gout is younger. The natural course of gout can be divided into four phases, namely, asymptomatic hyperuricemia, acute phase, intermittent phase, and chronic phase. The onset of gout causes great pain to the patient. Generally, western medicine for treating gout will have more or less side effects, and it is easy to relapse, which makes the gout cure.

Summary of the invention

In view of the above technical problems, the present invention provides a traditional Chinese medicine composition for treating gout and a preparation method thereof. The traditional Chinese medicine composition for treating gout of the present invention is composed of the following components by weight: 20-40 parts of sea breeze, 2-7 parts of sea sand, 8-15 parts of Lysimachia, 8-15 parts of Phellodendron, and 8-15 of Magnolia. Parts, 8 to 15 parts of black beans, 2 to 7 parts of medlar, 2 to 7 parts of schisandra, 2 to 7 parts of licorice, 2 to 7 parts of pulsatilla, 2 to 7 parts of Chuanpu, 2 to 7 parts of medlar, 2 to 7 parts of turtle shell 2 to 7 parts of Alisma, 8 to 15 parts of dried tangerine peel, 2 to 7 parts of chicken inner gold, 2 to 7 parts of Sichuan Fritillaria, 2 to 7 parts of Amomum villosum, 2 to 7 parts of Dendrobium, 2 to 7 parts of myrrh, 8 to 15 servings of spatholobus.

Further, the traditional Chinese medicine composition for treating gout of the present invention is composed of the following parts by weight: 25 to 35 parts of sea breeze, 4 to 6 parts of sea sand, 9 to 12 parts of Lysimachia, 9 to 12 parts of Phellodendron, and Magnolia 9 to 12 parts, 9 to 12 parts of black beans, 4 to 6 parts of medlar, 4 to 6 parts of schisandra, 4 to 6 parts of licorice, 4 to 6 parts of pulsatilla, 4 to 6 parts of Chuanpu, 4 to 6 parts of medlar, 4 to 6 parts of scorpion, 4 ~6 parts, Alisma 4 to 6 parts, tangerine peel 9 to 12 parts, chicken inner gold 4 to 6 parts, Sichuan Fritillaria 4 to 6 parts, Amomum villosum 4 to 6 parts, Dendrobium 4 to 6 parts, Myrrh 4 to 6 parts, 9-12 parts of spatholobus.

Specifically, the traditional Chinese medicine composition for treating gout of the present invention is composed of the following parts by weight: 30 parts of sea breeze, 5 parts of sea sand, 10 parts of Lysimachia, 10 parts of Phellodendron, 10 parts of Magnolia, 10 parts of black beans, and medlar. 5 parts, 5 parts of Schisandra, 5 parts of licorice, 5 parts of Pulsatilla, 5 parts of Chuanpu, 5 parts of medlar, 5 parts of turtle shell, 5 parts of Alisma, 10 parts of dried tangerine peel, 5 parts of chicken inner gold, 5 parts of Fritillaria, 5 parts of sand 5 parts of ren, 5 parts of sarcophagus, 5 parts of myrrh, and 10 parts of spatholobus.

The preparation method of the traditional Chinese medicine composition for treating gout of the present invention is as follows: according to the above formula amount, the raw materials are washed, dried and pulverized, added to 4 to 7 times by weight of water, and boiled for 40 minutes to 2 hours to separate the extract and the insoluble matter. Add the insoluble matter to 4 to 7 times the weight of water again, decoct for 2 to 5 hours, discard the insoluble matter, and combine the extracts to obtain.

Specifically, according to the above formula amount, each raw material is washed, dried and pulverized, added to 6 times by weight of water, and boiled for 1 hour, and the extract and the insoluble matter are separated, and the insoluble matter is again added to 5 times by weight of water and boiled for 3 hours. Discard the insoluble matter and combine the extracts. That is.

Among the main components of the present invention:

Sea breeze tastes bitter, bitter, and slightly warm. Go to the liver. Rheumatism, through the meridians, stop sputum pain. It is used for cold and dampness, pain in the limbs, restraint of the tendons, and unfavorable flexion and extension.

Money grass is sweet, salty, and slightly cold. Liver, gallbladder, kidney, bladder. Lee dampness, diuretic pass, detoxification and swelling. For damp heat jaundice, biliary hypochondriac pain, stone shower, hot shower, urinary pain, swollen hemorrhoids, snake bites.

Cork tastes bitter and cold. Return to the kidney, bladder. There are heat and dampness, purging fire in addition to steaming, detoxification treatment of sores. For damp heat diarrhea, jaundice urinary red, under the yin itching, hot dripping pain, athlete's foot sputum, bone steaming heat, night sweats, nocturnal emission, sore swollen poison, eczema wet sore. Salt, cypress, nourishing yin and reducing fire. For yin deficiency fire, night sweats and bone steaming.

Magnolia tastes bitter, spicy, warm, and returns to the spleen, stomach, lungs, and large intestine. Dampness and dispelling, and the gas is full. For wet stagnation, vomiting and diarrhea, food stagnation, abdominal distension, constipation, sputum and cough.

The spatholobus sinensis is sweet, bitter, and warm, and it can be transferred to the liver and kidney, to promote blood circulation, to relieve pain, and to relax the muscles. For irregular menstruation, dysmenorrhea, amenorrhea, rheumatism, numbness, blood deficiency and chlorosis.

Black beans are sweet, slightly cold, flat, into the spleen, kidney. Bushen Yiyin, spleen and dampness, in addition to heat and detoxification.

Chenpi: bitter, spicy, warm. Return to the lungs, spleen. Regulate qi and spleen, dampness and phlegm. It is used for abdominal fullness, less vomiting and diarrhea, and more cough.

The traditional Chinese medicine composition for treating gout of the present invention uses Haifeng vine as a monarch medicine, and money grass, phellodendron, tangerine peel, magnolia, spatholobus, black bean as a medicine, sea gold sand, medlar, schisandra, pulsatilla, chuanpu, scorpion, turtle shell , Alisma, Chicken Jin, Chuan Fritillaria, Amomum, Dendrobium, Myrrh is the adjuvant, licorice is the medicine. Through scientific compatibility, the synergy of various medicinal properties, the whole side has rheumatoid pain, swollen sore, clearing heat and detoxification, phlegm dampness, promoting blood circulation and collaterals, reducing swelling and relieving pain, can be used to treat various types of gout attacks, and The side effects are small. The preparation process is simple and the curative effect is remarkable.

For a better understanding and implementation, the invention is described in detail below.

detailed description

Preparation Example 1

The preparation method of the traditional Chinese medicine composition for treating gout of the invention is:

According to the weight, 20 parts of sea breeze, 2 parts of sea golden sand, 8 parts of Chinese cabbage, 8 parts of Phellodendron, 8 parts of Magnolia, 8 parts of black beans, 2 parts of medlar, 2 parts of schisandra, 2 parts of licorice, 2 parts of ginseng, 2 parts of Chuanpu 2 parts, 2 parts of scorpion, 2 parts of turtle shell, 2 parts of Alisma, 8 parts of dried tangerine peel, 2 parts of chicken inner gold, 2 parts of Fritillaria, 2 parts of Amomum villosum, 2 parts of Dendrobium, 2 parts of myrrh, 2 pieces of spatholobus Wash, dry and pulverize, add 4 times the weight of water, decoct for 40min, separate the extract and insoluble matter, add the insoluble matter to 4 times the weight of water again, decoct for 2h, discard the insoluble matter, and combine the extract. That is.

Preparation Example 2

According to the weight, 40 parts of sea breeze, 7 parts of sea gold sand, 15 parts of Chinese cabbage, 15 parts of Phellodendron, 15 parts of Magnolia, 15 parts of black beans, 7 parts of medlar, 7 parts of schisandra, 7 parts of licorice, 7 parts of ginseng, Sichuan 7 parts, 7 parts of scorpion, 7 parts of turtle shell, 7 parts of Alisma, 15 parts of dried tangerine peel, 7 parts of chicken inner gold, 7 parts of Fritillaria, 7 parts of Amomum villosum, 7 parts of Dendrobium, 7 parts of myrrh, 7 blood vines Wash, dry and pulverize, add 7 times the weight of water, decoct for 2h, separate the extract and insoluble matter, add the insoluble matter to 7 times the weight of water again, decoct for 5h, discard the insoluble matter, and combine the extract. That is.

Preparation Example 3

According to the weight, 25 parts of sea breeze, 4 parts of sea golden sand, 9 parts of Chinese cabbage, 9 parts of Phellodendron, 9 parts of Magnolia, 9 parts of black beans, 4 parts of medlar, 4 parts of schisandra, 4 parts of licorice, 4 parts of ginseng, 4 parts of Sichuan 4 parts of Park, 4 parts of scorpion, 4 parts of turtle shell, 4 parts of Alisma, 9 parts of dried tangerine peel, 4 parts of chicken inner gold, 4 parts of Fritillaria, 4 parts of Amomum villosum, 4 parts of Dendrobium, 4 parts of myrrh, 4 parts of spatholobus 9 parts of washing, drying and pulverizing, adding 6 times the weight of water, boiling for 1h, separating the extract and insoluble matter, adding the insoluble matter to 6 times the weight of water again, boiling for 4 hours, discarding the insoluble matter, combining the extracts That's it.

Preparation Example 4

According to the weight, 35 parts of sea breeze, 6 parts of sea golden sand, 12 parts of Chinese cabbage, 12 parts of Phellodendron, 12 parts of Magnolia, 12 parts of black beans, 6 parts of medlar, 6 parts of schisandra, 6 parts of licorice, 6 parts of ginseng, 6 parts of Sichuan 6 pieces of Pak, 6 parts of scorpion, 6 parts of turtle shell, 6 parts of Alisma, 12 parts of dried tangerine peel, 6 parts of chicken inner gold, 6 parts of Fritillaria, 6 parts of Amomum villosum, 6 parts of Dendrobium, 6 parts of myrrh, 6 spatholobus 12 parts of washing, drying and pulverizing, adding 5 times the weight of water, boiling for 1.5h, separating the extract and insoluble matter, adding the insoluble matter to 5 times the weight of water again, boiling for 2.5 hours, discarding the insoluble matter, and merging The extract is obtained.

Preparation Example 5

According to the weight, 30 parts of sea breeze, 5 parts of sea golden sand, 10 parts of Chinese cabbage, 10 parts of Phellodendron, 10 parts of Magnolia, 10 parts of black beans, 5 parts of medlar, 5 parts of schisandra, 5 parts of licorice, 5 parts of ginseng, 5 parts 5 parts of Park, 5 parts of medlar, 5 parts of turtle shell, 5 parts of Alisma, 10 parts of dried tangerine peel, 5 parts of chicken inner gold, 5 parts of Fritillaria, 5 parts of Amomum villosum, 5 parts of Dendrobium, 5 parts of myrrh, spatholobus 10 parts of washing, drying and pulverizing, adding 6 times the weight of water, boiling for 1h, separating the extract and insoluble matter, adding the insoluble matter to 5 times the weight of water again, boiling for 3 hours, discarding the insoluble matter, combining the extracts That's it.

Clinical trial embodiment

In 120 patients with gout, the clinical manifestations were: the first metatarsophalangeal joint pain was progressively exacerbated, and it was tear-like, knife-cut or bite-like, unbearable, red, swollen, hot, painful and affected joints and surrounding tissues. Limited functionality, etc. The rats were divided into 6 groups and treated with the traditional Chinese medicine composition for treating gout prepared in Examples 1 to 5 of the present invention and the commercially available traditional Chinese medicine gout drugs, respectively, 3 times a day, 200 to 300 ml each time, for a total of 3 months. The statistical analysis by systematic clinical observation is summarized as follows:

Efficacy criteria: clinical cure - all symptoms disappeared; markedly - various symptoms were significantly improved; effective - various symptoms improved; ineffective - no change in various symptoms.

It can be seen from the clinical trial that the traditional Chinese medicine composition for treating gout of the present invention can alleviate various gout symptoms, and the therapeutic effect thereof is significantly different from that of the commercially available product, and has an unexpected technical effect, and is suitable for general gout patients.

Case embodiment

1. Wei, male, 41 years old, with a history of gout for 5 years, the clinical manifestation is the first metatarsophalangeal joint redness and heat pain, joint flexion and extension is unfavorable, there are nodules in the joint, and the preparation of the first embodiment of the present invention was started in January 2015. The traditional Chinese medicine composition for treating gout, 200 times a day, 200 ml each time, the symptoms disappear after 3 months, and the drug is stopped after 3 months of continuous administration, and there is no recurrence so far, and there is no side effect in all the medications.

2. Zhang, male, 33 years old, gout history for 3 years, the clinical manifestation is redness and swelling of the thumb joint of the finger. On the third day after the onset of the disease, the traditional Chinese medicine composition for treating gout prepared in Example 2 of the present invention was started, 3 times a day. After 200ml, the symptoms disappeared after 3 days, and there was no side effect during the whole medication.

3. Wang, male, 57 years old, 8 years of gout history, the clinical manifestations of the right foot lateral big toe swelling and pain, joint deformation, fever and other symptoms. In January 2015, the traditional Chinese medicine composition for treating gout prepared in Example 3 of the present invention was started, 3 times a day, 300 ml each time, the symptoms disappeared after 4 months, and the drug was stopped after 3 months of continuous use, and there was no recurrence so far. There is no side effect during the medication.

The present invention is not limited to the above embodiments, and various modifications or variations of the present invention are possible without departing from the spirit of the present invention. And the scope of the invention is intended to be included within the scope of the appended claims.

Claims

The invention relates to a traditional Chinese medicine composition for treating gout, which is characterized by the following components by weight: 20-40 parts of sea breeze, 2-7 parts of sea sand, 8-15 parts of Lysimachia, 8-15 parts of Phellodendron, Magnolia 8 to 15 parts, 8 to 15 parts of black beans, 2 to 7 parts of medlar, 2 to 7 parts of schisandra, 2 to 7 parts of licorice, 2 to 7 parts of pulsatilla, 2 to 7 parts of Chuanpu, 2 to 7 parts of medlar, and 2 to 7 parts of scorpion ～7 parts, 2 to 7 parts of Alisma, 8 to 15 parts of dried tangerine peel, 2 to 7 parts of chicken, 2 to 7 parts of Fritillaria, 2 to 7 parts of Amomum villosum, 2 to 7 parts of Amomum villosum, 2 to 7 parts of Dendrobium, 2 to 2 7 parts, 8 to 15 parts of spatholobus.
The traditional Chinese medicine composition for treating gout according to claim 1, which is composed of the following components by weight: 25 to 35 parts of sea breeze, 4 to 6 parts of sea sand, 9 to 12 parts of Chinese herb, and 9 to 12 pieces of Phellodendron chinense. 12 parts, 9 to 12 pieces of Magnolia, 9 to 12 parts of black beans, 4 to 6 parts of medlar, 4 to 6 parts of schisandra, 4 to 6 parts of licorice, 4 to 6 parts of ginseng, 4 to 6 parts of Sichuan, 4 to 6 parts of Sichuan, 4 to 6 6 parts, 4-6 parts of turtle shell, 4-6 parts of Alisma, 9-12 parts of dried tangerine peel, 4-6 parts of chicken inner gold, 4-6 parts of Sichuan Fritillaria, 4-6 parts of Amomum villosum L., 4-6 parts of Dendrobium 4 to 6 parts of myrrh, 9 to 12 parts of spatholobus.
The traditional Chinese medicine composition for treating gout according to claim 2, which is characterized by comprising the following components by weight: 30 parts of sea buckthorn, 5 parts of sea sand, 10 parts of Lysimachia, 10 parts of Phellodendron, 10 parts of Magnolia, 10 black beans, 5 parts, 5 parts of Schisandra, 5 parts of licorice, 5 parts of Pulsatilla, 5 parts of Chuanpu, 5 parts of medlar, 5 parts of turtle shell, 5 parts of Alisma, 10 parts of dried tangerine peel, 5 parts of chicken, 5 parts of chicken 5 parts of mother, 5 parts of Amomum villosum, 5 parts of Dendrobium, 5 parts of myrrh, and 10 parts of Spatholobus.
The method for preparing a traditional Chinese medicine composition for treating gout according to any one of claims 1 to 3, characterized in that: according to the above formula amount, each raw material is washed, dried and pulverized, and then added to 4 to 7 times by weight of water and fried. Boil for 40min ~ 2h, separate the extract and insoluble matter, add the insoluble matter to 4 to 7 times the weight of water, decoct for 2h ~ 5h, discard the insoluble matter, and combine the extract to obtain.
The method for preparing a traditional Chinese medicine composition for treating gout according to claim 4, characterized in that: according to the above formula amount, each raw material is washed, dried and pulverized, added to 6 times by weight of water, and boiled for 1 hour to separate the extract. And insoluble matter, the insoluble matter is again added to 5 times the weight of water, decocted for 3 hours, the insoluble matter is discarded, and the extract is combined to obtain.