CN104758369B - A kind of Chinese medicine composition and its preparation method and application - Google Patents

A kind of Chinese medicine composition and its preparation method and application Download PDF

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CN104758369B
CN104758369B CN201510205897.6A CN201510205897A CN104758369B CN 104758369 B CN104758369 B CN 104758369B CN 201510205897 A CN201510205897 A CN 201510205897A CN 104758369 B CN104758369 B CN 104758369B
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张红
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Abstract

The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine composition and its preparation method and application.A kind of Chinese medicine composition is mainly made of following raw material, by weight, 2 15 parts of Radix Glycyrrhizae, 5 20 parts of honeysuckle, 20 120 parts of Asiatic plantain, 10 35 parts of lycopodium calvatum.Chinese medicine composition provided by the invention, coordinated enhances between Radix Glycyrrhizae, honeysuckle, Asiatic plantain and lycopodium calvatum, the effect of with anti-inflammatory, analgesic and extraordinary releasing uric acid, increasing discharge capacity reduces uric acid, therapeutic effect is notable, and also have blood pressure lowering, clear liver and improve vision, shade fertilizer, expelling phlegm and arresting coughing and other effects.The preparation method of the Chinese medicine composition provided by the invention is carried out by way of decocting, it is simple and practicable, effective active composition content is high in obtained extract, and during decoction, it interacts between each effective active composition, effective high temperature fusion has been carried out, there is better therapeutic effect.

Description

A kind of Chinese medicine composition and its preparation method and application
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine composition and its preparation method and application.
Background technology
Gout, also known as " hyperuricemia " are a kind of because of disorders of purine metabolism, make disease caused by uric acid accumulation, category In arthritic one kind, also known as metabolic arthritis.The definition of gout is have a kind of substance being called purine in human body new old Disorder has occurred in metabolism, and the synthesis of uric acid (oxidation metabolites of purine) increases or discharge is reduced, and causes hyperuricemia, when When serum Uric Acid Concentration is excessively high, uric acid is deposited in joint, soft tissue, cartilage and kidney in the form of sodium salt, causes tissue Foreign matter inflammatory reaction is just gout.
Either mode is mainly Western medicine or infusion etc. to the drug of some existing treatment gouts, and Western medicine therapy mostly uses greatly Anti-inflammatory analgetic forces the modes such as anti-trioxypurine to control the state of an illness;In addition, there are also Chinese medicine therapeutic modalities, but many Chinese medicines are controlled The bulk pharmaceutical chemicals that the recipe for the treatment of is added are relatively more, and treatment cycle is long, and cannot effect a radical cure, such as application No. is 201210416621.9 patent application discloses a kind of drug and preparation method thereof for treating gout, it mainly by frankincense, 15 kinds of Radix Glycyrrhizae, pawpaw, monkshood, Chinese ephedra, Fructus Forsythiae, radix paeoniae rubra, the root of bidentate achyranthes, Radix Angelicae Sinensis, rhizoma anemarrhenae, cape jasmine, Radix Paeoniae Alba, rhizoma alismatis, kuh-seng, radix aconiti sinensis etc. Drug is prepared according to a certain weight ratio, and the bulk pharmaceutical chemicals needed are very more, and its effect reached is all improvement or nothing Side effect.
Existing treatment gout drug has the following disadvantages:
1., side effect it is big, such as many people of colchicin take after will appear the symptoms such as diarrhea, vomiting;
2., therapeutic effect be not thorough, recurrence is susceptible to, either in therapeutic process or after treatment end;
3., addition raw material type it is too many, cause the irritation taste of medicine too big, patient take for a long time, cause appetite to subtract It is weak etc..
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of Chinese medicine composition, and the Chinese medicine composition is without side-effects, treatment Significant effect, it is low-cost.
The second object of the present invention is to provide a kind of preparation method of the Chinese medicine composition, this method operation letter Just, liquid effective active composition obtained is high, and therapeutic effect is good.
The third object of the present invention is to provide the application of the Chinese medicine composition.The Chinese medicine composition have anti-inflammatory, The effect of analgesic and anti-trioxypurine repairs metabolism mainly by releasing uric acid, excludes uric acid road calculus, and be finally reached root Control gout;In addition, also have blood pressure lowering, clear liver and improve vision, long-term drinking has weight-reducing and other effects, and side effect is very small.
In order to realize that the above-mentioned purpose of the present invention, spy use following technical scheme:
A kind of Chinese medicine composition is mainly made of following raw material, by weight, 2-15 parts of Radix Glycyrrhizae, 5-20 parts of honeysuckle, 20-120 parts of Asiatic plantain, 10-35 parts of lycopodium calvatum.
Radix Glycyrrhizae has and invigorates the spleen and benefits qi containing glycyrrhizic acid and glycyrrhizin etc., clearing heat and detoxicating, expelling phlegm and arresting coughing, and relieving spasm to stop pain reconciles The effects that all medicines, uses herein, mainly the effect of heat clearing and inflammation relieving, reconciliation and protecting spleen and stomach.
Asiatic plantain is commonly called as " Bothriospermum Chinese ", " plantain seed ", annual herb plant.Taproot is long, has most lateral roots, how much meat Matter.Rhizome is short.Phyllopodium life is in rosette-stape, is lieed down, tiltedly exhibition or upright;Blade papery, ellipse, ellipticity lanceolar or ovate are draped over one's shoulders Aciculiform, 3-12 centimetres long, 1-3.5 centimetres wide, the anxious point or micro- blunt of apex, edge has shallow wavy cognate, irregular sawtooth or tooth, Base portion wide wedge shape to narrow wedge shape, under be extended down to petiole arteries and veins 5-7 items, above it is slightly concave fall into, obviously swelled in the back side, two sides sparsely grow white Pubescence;Petiole is 2-6 centimetres long, and base portion is expanded into sheath shape.The effect of with diuresis, clearing damp, heat-clearing, improving eyesight.
Lycopodium calvatum nickname riparian greenbrier root and rhizome, big suitable muscle rattan, smallflower magnoliavine root, muscle stretched by the tuber of stemona, water shakes bamboo etc., perennial herb, stolon In thin cylinder, slightly curved song is long up to 2m, diameter 1-3mm, under have yellow-white radicula.Erect stern makees two dichotomies.Ye Mi On raw stem, helical arrangement, shrinkage bending, linear or aciculiform, long 3-5mm, yellow green to fallow, hairless, apex aristiform, Full edge, it is easily cataclasm.Matter is soft, and section skin zone is light yellow, woody part off-white color.It is odorless, it is lightly seasoned.With expelling wind and clearing away cold, dehumidification swelling, The effect of relaxing tendons and activating collaterals can be used for wind-cold-dampness arthralgia, and muscle arteries and veins contraction aches carbuncle, and bruises and spasms are controlled in external application.
Chinese medicine composition provided by the invention, coordinated enhances between Radix Glycyrrhizae, honeysuckle, Asiatic plantain and lycopodium calvatum, tool There is the effect of anti-inflammatory, analgesic and extraordinary releasing uric acid, increasing discharge capacity reduces uric acid, and therapeutic effect is notable, and also has drop Blood pressure, clear liver and improve vision, shade fertilizer, expelling phlegm and arresting coughing and other effects.
In order to further enhance the mutual chemiluminescence between each raw material, it is preferable that by weight, Radix Glycyrrhizae 5-10 Part, 10-18 parts of honeysuckle, 50-100 parts of Asiatic plantain, 15-30 parts of lycopodium calvatum.
It is highly preferred that by weight, 7-8 parts of Radix Glycyrrhizae, 12-15 parts of honeysuckle, 70-80 parts of Asiatic plantain, lycopodium calvatum 20-25 Part.
The present invention also provides the preparation methods of the Chinese medicine composition, take each raw material by weight, add water to cook.
The preparation method is carried out by way of decocting, simple and practicable, effective active composition content in obtained extract Height, and during decoction, interact between each effective active composition, effective high temperature fusion has been carried out, has been had more preferable Therapeutic effect.
Further, each raw material first cleans before decoction, then dries to leather hard, is cleaned up, and shines It is dry, segment or slice.By removal of impurities so that each raw material is more pure, the interference of other impurities is prevented;It is clear by first drying again It washes, then by drying segment or slice, to be easy to the dissolution of the effective active composition when water decocts.
Preferably, described decoct is:First with being boiled by fire, fiery 5-10min stewed slowly is then turned down.Pass through boiling for big fire Boiling is stewed with the slow of small fire, so that flavour of a drug is overflowed completely, effective active composition is fully dissolved out.Wherein, big fire refers generally to power in 1600W More than;Small fire refers generally to power in 1000W or less.
In order to make the effective active composition in each raw material be fully dissolved out, it is preferable that the total weight ratio of the water and each raw material It is 15~30:1, more preferably 20~25:1.
The present invention also provides the Chinese medicine compositions to prepare the application in treating gout drug.
The present invention also provides the Chinese medicine compositions to prepare the application in treating blood-pressure drug.
The present invention also provides the Chinese medicine compositions to clear liver and improve vision and the application in expelling phlegm and arresting coughing drug in preparation treatment.
Chinese medicine composition provided by the invention has the function of that anti-inflammatory, analgesic, anti-trioxypurine are repaiied mainly by releasing uric acid Multiple metabolism excludes uric acid road calculus, and is finally reached the antipodagric purpose of root.
Meanwhile the Chinese medicine composition also has blood pressure lowering, clears liver and improve vision, expelling phlegm and arresting coughing and other effects, and side effect is very small, It can be fabricated to herbal tea health, and the diseases such as gout can be prevented with this.
Compared with prior art, beneficial effects of the present invention are:
(1) the specific selection Radix Glycyrrhizae of the present invention, honeysuckle, Asiatic plantain and lycopodium calvatum this 4 kinds of Chinese herbal medicines are used in conjunction with each other, and The dosage between each raw material is limited, coordinated enhances between each raw material, has anti-inflammatory, analgesic and extraordinary releasing uric acid drop The effect of uric acid, therapeutic effect is notable, and also have blood pressure lowering, clear liver and improve vision, expelling phlegm and arresting coughing, fall fire, decorporation are let out, steady generation It thanks, shade fertilizer and other effects;
(2) in order to further enhance the collaboration enhancing effect between each raw material, the present invention has further defined each raw material Between dosage;
(3) the present invention also provides the preparation methods of the Chinese medicine composition, and the mode of decocting is selected to process, simple easy It goes, effective active composition content is high in obtained extract, and during decoction, phase interaction between each effective active composition With, carried out effective high temperature fusion, have better therapeutic effect;
(4) present invention is also by pre-processing each raw material, to be easy to the dissolution of the effective active composition when water decocts;
(5) present invention is also by way of limiting the amount of water decocted and decoction, make effective active in each raw material at Divide and be fully dissolved out, fully merge, effective active composition content is high in obtained extracting solution, takes rear good absorbing, increases and treats effect Fruit.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is The conventional products of commercially available acquisition can be passed through.
Embodiment 1
Take following raw material:Radix Glycyrrhizae 2g, honeysuckle 20g, Asiatic plantain 20g, lycopodium calvatum 35g;
By each impurity removing, then dries to leather hard, cleaned up, dried, segment or slice;
Add water 2310ml, first with being boiled by fire, then turns down fiery 10min stewed slowly.
Embodiment 2
Take following raw material:Radix Glycyrrhizae 5g, honeysuckle 10g, Asiatic plantain 100g, lycopodium calvatum 15g;
By each impurity removing, then dries to leather hard, cleaned up, dried, segment or slice;
Add water 2400ml, first with being boiled by fire, then turns down fiery 7min stewed slowly.
Embodiment 3
Take following raw material:Radix Glycyrrhizae 7g, honeysuckle 15g, Asiatic plantain 80g, lycopodium calvatum 20g;
By each impurity removing, then dries to leather hard, cleaned up, dried, segment or slice;
Add water 2200ml, first with being boiled by fire, then turns down fiery 6min stewed slowly.
Embodiment 4
Take following raw material:Radix Glycyrrhizae 8g, honeysuckle 12g, Asiatic plantain 70g, lycopodium calvatum 25g;
By each impurity removing, then dries to leather hard, cleaned up, dried, segment or slice;
Add water 2300ml, first with being boiled by fire, then turns down fiery 8min stewed slowly.
Embodiment 5
Take following raw material:Radix Glycyrrhizae 10g, honeysuckle 18g, Asiatic plantain 50g, lycopodium calvatum 30g;
By each impurity removing, then dries to leather hard, cleaned up, dried, segment or slice;
Add water 2700ml, first with being boiled by fire, then turns down fiery 9min stewed slowly.
Embodiment 6
Take following raw material:Radix Glycyrrhizae 15g, honeysuckle 5g, Asiatic plantain 120g, lycopodium calvatum 10g;
By each impurity removing, then dries to leather hard, cleaned up, dried, segment or slice;
Add water 2250ml, first with being boiled by fire, then turns down fiery 5min stewed slowly.
Experimental example 1
Embodiment 1-6 is repeated, enough liquids are made and are taken for experimental example, wherein each embodiment selects 50 Patient with gout is taken, and takes 3 months, and a daily auxiliary can be taken before or after meals, and daily dose is 1500-2000ml, Then effect is counted;Application No. is the formula of 0019-0028 sections of preferred embodiment of 201210416621.9 specification, reference is said Liquid made of the preparation method of 0061-0063 sections of bright book as a control group, selects 50 patient with gout to take according to quantity, takes 3 months, count therapeutic effect.
Effect is divided into healing, effectively and invalid, cures and disappears for gout symptom;It is effectively substantially reduced for gout symptom;Nothing Effect is gout symptom without significant change.Obtain that the results are shown in Table 1.
The statistics effect of 1 patient with gout of table
Group It cures Effectively In vain
Embodiment 1 48 2 0
Embodiment 2 49 1 0
Embodiment 3 50 0 0
Embodiment 4 49 1 0
Embodiment 5 48 2 0
Embodiment 6 49 1 0
Control group 42 6 2
As it can be seen from table 1 Chinese medicine composition provided by the invention reaches 96% or more to the cure rate of patient with gout, tool There is the therapeutic effect of highly significant.In addition, generated without any discomfort during taking, and appetite enhances.
Metabolic disturbance, uric acid excretion are unsmooth, are improved using Chinese medicine composition provided by the invention, keep metabolism extensive It is multiple normal, uric acid road calculus is excluded, to effect a radical cure gout.But it needs to be aided with existing method treatment in acute attack stage.
The liquid of Chinese medicine composition provided by the invention is a treatment phase first 15-20 days taken, and dose can be appropriate Increase, be a cycle by 30 days, be second period by 60 days, 100 days are the third period, if severe patient, according to reality Border situation can be taken and arrive or so half a year.
The excessively high food of purine albumen, such as internal organ, seafood, bean food are not eaten during medication, not drunk, to the greatest extent Amount not eat stodge.What can eat after rehabilitation, but form the eating habit of health.
Specific clinic example:
1. Zhang, man, Luzhou, Sichuan people 30 years old, is diagnosed as gout, is treated repeatedly through hospital, be only by Morbidity control, There is no thoroughly eradicate;After start to take Chinese medicine provided by the invention, first 15-20 days of medication because the state of an illness than more serious, does not have When having apparent feeling, but take medicine 30 days or so, the state of an illness is controlled, and incidence is substantially reduced, and rear lasting medication is arrived Incidence is almost nil when 60 days or so.It has fully recovered when by 100 days or so.Up to now, gout is not again Recurrence, life are not also affected.
2. Lee, man, Sichuan people from Chengdu 35 years old, is diagnosed as gout, is repeatedly treated to hospital, though the state of an illness is controlled, But it is not effected a radical cure.Start to take Chinese medicine provided by the invention later, since the state of an illness is than more serious, first 10 days of medication do not have There is apparent feeling, when medication 30 days or so, the state of an illness is controlled, and incidence is substantially reduced, rear lasting medication, by 60 days Incidence is almost nil when left and right, has fully recovered when by 90 days or so.Up to now, gout does not recur again, Life is not also affected.
Experimental example 2
Enough liquids are made by embodiment 1-6 to take for experimental example, wherein each embodiment selects 50 high blood Pressure patient takes, and takes 2 months, and a daily auxiliary can be taken before or after meals, and daily dose is 1500-2000ml, so After count effect.
Effect is divided into healing, effectively and invalid, cures and is down to normally for blood pressure, it is no longer necessary to take depressor;Effectively it is Blood pressure is decreased obviously, it is still necessary to take a small amount of depressor;In vain for blood pressure without significant change.Obtain that the results are shown in Table 2.
The statistics effect of 2 hypertensive patient of table
Group It cures Effectively In vain
Embodiment 1 47 3 0
Embodiment 2 49 1 0
Embodiment 3 50 0 0
Embodiment 4 49 1 0
Embodiment 5 48 2 0
Embodiment 6 48 2 0
From table 2 it can be seen that Chinese medicine composition provided by the invention there is the treatment of highly significant to imitate hypertensive patient Fruit.In addition, generated without any discomfort during taking, and appetite enhances.
In addition, the symptoms such as Chinese medicine composition provided by the invention is also applied to clear liver and improve vision, expelling phlegm and arresting coughing;Such as suffer from tracheae Scorching or flu patient by Chinese medicine composition provided by the invention decoct and be taken, after taking three days can sensory symptoms it is bright It is aobvious to mitigate, it can be cured after taking 10 days, the effect for playing extraordinary expelling phlegm and arresting coughing, clearing liver and improving vision.
Herbal tea is made by the formula to drink, also fall fire, decorporation is let out, and steady to be metabolized, shade fertilizer, steady to be depressured, and is clear liver and improved vision Health-care efficacy, and it is without side-effects.
Chinese medicine composition provided by the invention has the following advantages:
(1) addition raw material type is few, this 4 kinds of Chinese herbal medicine mutual cooperations of Radix Glycyrrhizae, honeysuckle, Asiatic plantain and lycopodium calvatum is selected to make With, it is generated without any discomfort when taking, it is safe without side-effects;
(2) present invention is specific and limit the dosage between each raw material, and coordinated enhances between each raw material, have anti-inflammatory, The effect of analgesic, extraordinary releasing uric acid, increasing discharge capacity reduces uric acid.Therapeutic effect is thorough, it is not easy to recur;And also have Steady blood pressure lowering, clear liver and improve vision, expelling phlegm and arresting coughing, fall fire, decorporation are let out, are surely metabolized, shade fertilizer and other effects;
(3) preparation method of the Chinese medicine composition provided by the invention, selects the mode of decocting to process, simple and practicable, Effective active composition content is high in obtained extract, and during decoction, interacts between each effective active composition, Effective high temperature fusion has been carried out, there is better therapeutic effect;
(4) present invention is also by pre-processing each raw material, to be easy to the dissolution of the effective active composition when water decocts;
(5) present invention is also by way of limiting the amount of water decocted and decoction, make effective active in each raw material at Divide and be fully dissolved out, fully merge, effective active composition content is high in obtained extracting solution, takes rear good absorbing, increases and treats effect Fruit.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from the present invention's Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims Including belonging to all such changes and modifications in the scope of the invention.

Claims (11)

1. a kind of Chinese medicine composition for effecting a radical cure gout and blood pressure lowering, which is characterized in that be made of following raw material, by weight Meter, 2-15 parts of Radix Glycyrrhizae, 5-20 parts of honeysuckle, 20-120 parts of Asiatic plantain, 10-35 parts of lycopodium calvatum.
2. Chinese medicine composition according to claim 1, which is characterized in that by weight, 5-10 parts of Radix Glycyrrhizae, honeysuckle 10-18 parts, 50-100 parts of Asiatic plantain, 15-30 parts of lycopodium calvatum.
3. Chinese medicine composition according to claim 1, which is characterized in that by weight, 7-8 parts of Radix Glycyrrhizae, honeysuckle 12-15 parts, 70-80 parts of Asiatic plantain, 20-25 parts of lycopodium calvatum.
4. the preparation method of any one of the claim 1-3 Chinese medicine compositions, which is characterized in that each raw material is taken by weight, It adds water to cook.
5. preparation method according to claim 4, which is characterized in that each raw material first cleans before decoction, then dries in the air It shines to leather hard, is cleaned up, dried, segment or slice.
6. preparation method according to claim 4, which is characterized in that the decoction is:First with being boiled by fire, then turn down Fiery 5-10min stewed slowly.
7. preparation method according to claim 4, which is characterized in that the total weight ratio of the water and each raw material is 15~ 30:1.
8. preparation method according to claim 7, which is characterized in that the total weight ratio of the water and each raw material is 20~ 25:1.
9. any one of the claim 1-3 Chinese medicine compositions are preparing the application in treating gout drug.
10. application of any one of the claim 1-3 Chinese medicine compositions in preparing blood-pressure drug.
11. any one of the claim 1-3 Chinese medicine compositions clear liver and improve vision and the application in expelling phlegm and arresting coughing drug in preparation.
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