CN111671864A

CN111671864A - Traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy and preparation method thereof

Info

Publication number: CN111671864A
Application number: CN202010657964.9A
Authority: CN
Inventors: 张玉田
Original assignee: Sinochem Technology Co ltd
Current assignee: Sinochem Technology Co ltd
Priority date: 2020-07-09
Filing date: 2020-07-09
Publication date: 2020-09-18

Abstract

The invention provides a traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy and a preparation method thereof; the medicine is prepared from the following medicines in parts by weight: 10-30 parts of caulis spatholobi; 20-30 parts of rhizoma drynariae; 10-30 parts of prepared fleece flower root; 20-30 parts of astragalus; 15-30 parts of malt; 20-30 parts of epimedium; 20-30 parts of ginseng; 15-30 parts of Chinese yam; 25-30 parts of prepared rhizome of rehmannia; 20-30 parts of angelica; 5-10 parts of ligusticum wallichii; 10-20 parts of bighead atractylodes rhizome. The traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy overcomes all the defects of the medicines due to the side effect of the recombinant human granulocyte colony-stimulating factor, improves the physique of a patient while increasing blood, ensures the implementation of the radiotherapy and chemotherapy treatment course, can increase the curative effect of the radiotherapy and chemotherapy, and has low price, exact curative effect, convenient administration and popularization value.

Description

Traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy and preparation method thereof

Technical Field

The invention relates to the field of biomedicine; in particular to a traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy and a preparation method thereof.

Background

At present, malignant tumor is the first cause of death of residents due to threat of human health, and radiotherapy and chemotherapy are common treatment schemes for patients suffering from malignant tumor. The radiotherapy and chemotherapy drugs can kill tumor cells and damage normal cells to a certain extent. Since bone marrow cells grow faster, chemotherapy drugs also cause the greatest damage to bone marrow cells, resulting in a decrease in their regenerative capacity. The decrease of the number of white blood cells, red blood cells and platelets is one of the most common complications in the process of tumor radiotherapy and chemotherapy. Therefore, the bone marrow suppression is very important, if the bone marrow suppression is not controlled well, not only the radiotherapy and the chemotherapy are difficult to carry out, but also the whole immune mechanism of the human body is reduced, the physical weakness is caused, the infection is easy to cause and other complications, and the life of a patient is threatened, so the control of the bone marrow suppression reaction is one of the key factors for determining the good and bad curative effect of the radiotherapy and the chemotherapy, the control of tumors and the recovery of the patient.

Myelosuppression is the most common toxic response of chemoradiotherapy, with leukopenia, particularly neutropenia, occurring most frequently and earliest, followed by thrombocytopenia, with relatively little decrease in peripheral red blood cell count and hemoglobin levels. The damage degree of the anti-cancer medicine to the bone marrow is related to various factors such as the type, the dosage and the treatment cycle number of the medicine, the age, the liver and kidney functions of a patient, the combination of the same medicine and the like. Severe myelosuppression can be associated with infection, bleeding, and even life risk. Colony Stimulating Factors (CSF) are a group of multipotential hematopoietic cell growth factors, are the most main treatment methods for granulocytopenia caused by tumor radiotherapy and chemotherapy in modern medicine at present, and also play an important role in bone marrow suppression caused by tumor chemotherapy in traditional Chinese medicine, acupuncture and moxibustion and food therapy.

The recombinant human granulocyte colony stimulating factor injection has the side effects that: musculoskeletal system: sometimes, there are symptoms of muscular soreness, bone pain, lumbago and chest pain. A digestive system: sometimes, the appetite may be poor, or the liver glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase may be increased. And others: some people have fever, headache, hypodynamia and rash, and ALP and LDH are increased. Shock, interstitial pneumonia, adult respiratory distress syndrome, and increased number of immature cells occur in very few people. Because the bone marrow reserve of patients is limited, the long-term use of the medicine for stimulating and hemopoiesis of bone marrow can lead to the exhaustion of the bone marrow reserve of human bodies, the curative effect is worse and worse, and simultaneously, the patients have worse constitution and lead to the death of the patients caused by complications such as infection and the like. Traditional Chinese medicine acupuncture and moxibustion, medicinal moxibustion and the like generally play a role in auxiliary treatment, are developed less in general western medicine hospitals, and have the problems of high price, inconvenience in taking and the like although traditional Chinese medicine treatment has a certain effect.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy and a preparation method thereof.

In a first aspect, the invention is realized by the following technical scheme:

the invention relates to a traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy, which is prepared from the following medicines in parts by weight:

10-30 parts of caulis spatholobi; 20-30 parts of rhizoma drynariae; 10-30 parts of prepared fleece flower root; 20-30 parts of astragalus; 15-30 parts of malt; 20-30 parts of epimedium; 20-30 parts of ginseng; 15-30 parts of Chinese yam; 25-30 parts of prepared rhizome of rehmannia; 20-30 parts of angelica; 5-10 parts of ligusticum wallichii; 10-20 parts of bighead atractylodes rhizome.

Preferably, the medicine is prepared from the following medicines in parts by weight:

30 parts of caulis spatholobi; 30 parts of rhizoma drynariae; 30 parts of prepared tuber fleeceflower root; 30 parts of astragalus; 30 parts of malt; 30 parts of epimedium; 30 parts of ginseng; 30 parts of Chinese yam; 30 parts of prepared rhizome of rehmannia; 30 parts of angelica; 10 parts of ligusticum wallichii; 20 parts of bighead atractylodes rhizome.

In a second aspect, the present invention also relates to a preparation method of the aforementioned traditional Chinese medicine preparation for alleviating bone marrow suppression caused by chemotherapy, wherein the method comprises: the components are proportioned according to the following parts, decocted and extracted, added with auxiliary materials and refined into water pills;

the components and the components thereof are as follows: 10-30 parts of caulis spatholobi; 20-30 parts of rhizoma drynariae; 10-30 parts of prepared fleece flower root; 20-30 parts of astragalus; 15-30 parts of malt; 20-30 parts of epimedium; 20-30 parts of ginseng; 15-30 parts of Chinese yam; 25-30 parts of prepared rhizome of rehmannia; 20-30 parts of angelica; 5-10 parts of ligusticum wallichii; 10-20 parts of bighead atractylodes rhizome.

The components of the application have the following effects:

caulis Spatholobi can increase blood cell, hemoglobin, and resist cancer;

astragalus root is sweet and warm in nature and flavor, good at tonifying qi; the caulis spatholobi is bitter, sweet and warm in taste, can enrich and activate blood, the peanut coat is sweet and flat in taste, and the blood-nourishing and bleeding-stopping are used as ministerial drugs. The medicines are synthesized to achieve the effects of benefiting qi and nourishing blood, replenishing essence and benefiting marrow, and balancing yin and yang-qi and blood. Just as Zhang Jingyue said: the medicine well embodies the point that a person who is good at tonifying yin must seek yin from yang, yin must rise to yang and spring source is inexhaustible, a person who is good at tonifying yang must seek yang from yin, and yang must rise to yin rib and biochemistry is infinite, and is suitable for vital-deficiency bone marrow suppression caused by various anti-tumor treatments.

The rhizoma drynariae has the following effects: (1) the beneficial skeleton: the rhizoma drynariae has one of the main effects, can enable bones to better absorb the substance, improve the levels of blood calcium and blood phosphorus, and also improve cartilage cells, and if people with fracture conditions take some rhizoma drynariae properly, the rhizoma drynariae is greatly helpful for promoting the recovery of the disease; (2) protecting blood vessels: the rhizoma drynariae contains a large amount of dihydroflavonol glycosides, sugar acid salts, steroid lactones and other substances, which have certain effects on reducing blood fat and cholesterol in blood vessels and can increase elasticity and permeability of blood vessels; (3) preventing heart diseases: the main reason is that the rhizoma drynariae contains a substance called dihydroflavonol glycoside, which can enhance the contractility of cardiac muscle and increase the blood flow of heart, thereby playing the role of preventing heart disease; (4) treatment of kidney deficiency: if people are old, people can easily get kidney deficiency if not paying much attention at ordinary times, and in this time, some drynaria fortunei can be tried for adjuvant treatment, so that the conditions of lumbago, limb weakness and the like caused by kidney deficiency can be effectively relieved; (5) protecting the liver: the rhizoma drynariae can inhibit damage of western medicines to the liver and reduce the toxicity of the medicines, thereby playing a role in protecting the liver. Moreover, some components in the rhizoma drynariae can improve the ability of transaminase and enhance the detoxification and metabolic capability of the liver. (6) And (3) reducing blood fat: the rhizoma drynariae contains various components with the effect of clearing serum cholesterol, such as dihydroflavonol glycoside, fluid lactone polysaccharide acid salt and the like, particularly the latter has better and obvious effect, can not increase the cholesterol in tissues while reducing the blood fat, and has the function of resisting atherosclerosis.

Astragalus has effects of promoting metabolism and has hormone-like effect;

the polygonum multiflorum is a root tuber of polygonum multiflorum of the family Polygonaceae, has the effects of blackening beard and hair, strengthening bones and muscles, tonifying liver and kidney, tonifying essence and blood, delaying aging, reducing blood fat, promoting hematopoiesis, obviously increasing the red blood cell value of bone marrow, and can be used for treating premature gray hair and white beard hair.

Astragalus root: has effects in promoting metabolism and has hormone-like effect.

Malt: promoting qi circulation, resolving food stagnation, invigorating spleen, promoting appetite, and relieving lactation.

Herba epimedii: tonify kidney yang, strengthen tendons and bones, dispel wind-damp. They belong to yang tonics classified under deficiency tonics.

Ginseng: ginseng is sweet in taste, slightly bitter in flavor, slightly warm in nature, and has the effects of invigorating spleen, lung, heart and kidney meridians, and moistening qi and body, and increasing or decreasing blood flow; has the effects of invigorating qi, relieving depletion, invigorating spleen, benefiting lung, calming heart, improving intelligence, nourishing blood, and promoting fluid production.

Chinese yam: tonify qi, nourish yin, tonify spleen, lung and kidney, secure essence and stop leukorrhagia.

Prepared rhizome of rehmannia: tonifying kidney, strengthening heart, promoting urination, resisting aging, lowering hypertension, promoting hematopoiesis of bone marrow, nourishing blood, and tonifying deficiency.

Chinese angelica: has effects in nourishing blood, regulating menstruation, relieving pain, moistening dryness, and smoothing intestine.

The ligusticum wallichii has the following 3 effects: (1) for coronary heart disease and angina pectoris with symptoms of chest distress and breath holding, frequent precordial tenderness, it can be used with Carthami flos zd, Saviae Miltiorrhizae radix, lignum Dalbergiae Odoriferae, and radix Paeoniae Rubra, formula 2 for coronary heart disease; (2) for diseases due to qi and blood stagnation, such as premature menstruation and excessive menstruation, it is combined with Sheng Di Huang, mu Dan Pi and Dang Gui, etc.; it is used for prolonged menstruation, more than 1 time after one and a half months, and severe dysmenorrhea and leukorrhagia during menstruation, and is combined with Dang Gui, Pao Jiang, Du Zhong and Rou Gui.

(3) Can be used for treating dysmenorrhea, if it is painful in the first few days and then it is used together with radix Angelicae sinensis, semen Persicae and Carthami flos; for irregular menstruation and no other discomfort, it is combined with Dang Gui, Tao ren, gan Jiang and Rou Gui; for postpartum abdominal pain, it is combined with Dang Gui and Pao Jiang.

White atractylodes rhizome: has effects in invigorating qi, invigorating spleen, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage.

The components involved in the invention also have synergistic effect: ginseng, radix Ginseng, can reinforce primordial qi, consolidate and promote the production of body fluid; astragalus root, radix astragali, replenishing qi to strengthen superficies, arresting sweating and relieving depletion, prepared fleece flower root, radix polygoni multiflori, tonifying liver and kidney, and benefiting essence and blood; prepared rehmannia root, radix rehmanniae Praeparata, blood-enriching and yin-nourishing, and caulis Spatholobi, blood-enriching and blood-activating. The five medicines have the effects of warming kidney, tonifying qi, nourishing yin and nourishing blood, and are monarch medicines. The largehead atractylodes rhizome has the effects of strengthening spleen and tonifying qi, and eliminating dampness and inducing diuresis; herba Epimedii is effective in invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness; the yam has the effects of tonifying spleen and nourishing stomach, promoting the production of body fluid and benefiting lung, and tonifying kidney and arresting seminal emission; rhizoma Drynariae has effects of invigorating kidney, strengthening bone, promoting blood circulation, and removing blood stasis; malt strengthens spleen and stomach, soothes liver and promotes qi circulation. The five medicines have the effects of tonifying spleen and kidney, and promoting qi and blood circulation. The angelica sinensis can enrich and activate blood, and the ligusticum wallichii can activate and promote qi circulation as adjuvant drugs. The medicines can supplement qi and nourish yin, warm kidney and invigorate spleen, nourish blood and activate blood to achieve the effects of replenishing essence and nourishing marrow.

The traditional Chinese medicine preparation for relieving the bone marrow suppression caused by the chemotherapy is used for treating the diseases of leucocyte, erythrocyte, platelet degradation and the like caused by the bone marrow suppression caused by the tumor radiotherapy and chemotherapy and can also relieve the diseases of liver and kidney function damage and the like caused by the radiotherapy and chemotherapy. Or used for fatigue, asthenia, cold limbs, aversion to cold, anorexia, and hemogram.

To illustrate the therapeutic effect of the Chinese medicinal preparation for relieving the bone marrow suppression caused by chemotherapy, the following clinical treatment data are provided: instructions for clinical use: 9 g, taken orally three times a day; the administration mode is as follows: it is administered with warm boiled water; 10000 patients are used by hospital agreement and prescription for 15 years, the effective rate of clinical chemotherapy prevention is more than 80%, the effective rate of chemotherapy after use is more than 70%, and no obvious side effect exists.

The method of the invention has the following advantages:

(1) the traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy overcomes all the defects of the medicines due to the side effect of the recombinant human granulocyte colony-stimulating factor, improves the physique of a patient while increasing blood, ensures the implementation of the radiotherapy and chemotherapy treatment course, can increase the curative effect of the radiotherapy and chemotherapy, and has low price, exact curative effect, convenient administration and popularization value.

(2) The traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy is used for treating more than 1 ten thousand cases of patients with digestive tract reaction caused by malignant tumors, has better curative effect on treating diseases such as gastritis and gastric ulcer, preventing and treating nausea and vomiting reaction caused by chemotherapy, can increase clinical curative effect, enhance the disease resistance of human bodies, prevent transfer and relapse, and has popularization and use values.

Detailed Description

The present invention will be described in detail with reference to specific examples. It should be noted that the following examples are only illustrative of the present invention, but the scope of the present invention is not limited to the following examples.

Example 1

The embodiment relates to a traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy, which is prepared from the following medicines in parts by weight:

The present invention also relates to a preparation method of the aforementioned traditional Chinese medicine preparation for alleviating bone marrow suppression caused by chemotherapy, the method comprises: the components are proportioned according to the following parts, decocted, extracted, added with auxiliary materials and refined into water pills;

the components and the components thereof are as follows: 30 parts of caulis spatholobi; 30 parts of rhizoma drynariae; 30 parts of prepared tuber fleeceflower root; 30 parts of astragalus; 30 parts of malt; 30 parts of epimedium; 30 parts of ginseng; 30 parts of Chinese yam; 30 parts of prepared rhizome of rehmannia; 30 parts of angelica; 10 parts of ligusticum wallichii; 20 parts of bighead atractylodes rhizome.

The components of the application have the following effects:

caulis Spatholobi can increase blood cell, hemoglobin, and resist cancer;

Astragalus has effects of promoting metabolism and has hormone-like effect;

In this embodiment, the prepared traditional Chinese medicine preparation for alleviating bone marrow suppression caused by chemotherapy is used for the following cases: the invention discloses a qi-tonifying and blood-generating pill, and relates to a traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy.

1. Plum women, born in 1961. China, Chengde City, lower board town Bei Jucun. The 3-month diagnosis in 2005 is the hospitalization of the double lung multiple metastasis of the uterine choriocarcinoma, the previous chemotherapy has 4-degree bone marrow suppression, and only 1-degree bone marrow suppression is achieved after the auxiliary treatment of the qi-tonifying and blood-generating pill, so that the course of the chemotherapy is smoothly completed. The focus is completely disappeared, and the disease is not relapsed and transferred in 15 years so far and is completely cured.

2. Mr. Li, man, born in 1957, Lingyuan city in Liaoning province, diagnosed as right lung squamous carcinoma in 2008, hospitalized with mediastinal lymph node metastasis, and given qi-tonifying and blood-producing pills for adjuvant therapy during chemotherapy, the patient has no myelosuppression side effect, the focus of disease disappears completely after one month of reexamination after the treatment, and the normal life has no metastasis and recurrence in 12 years.

3. Plum women, born 1948, san gou town, Chengde county, Chengde City. Hospitalization for malignant lymphoma was diagnosed at 10 months 2012. 9 g of qi-tonifying and blood-generating pills are orally taken three times a day after admission, CHOP scheme chemotherapy is simultaneously carried out for 21 days for one cycle and six cycles in total, toxic and side effects such as bone marrow suppression, liver and kidney function damage and the like do not appear during the chemotherapy, the focus completely disappears after the chemotherapy, and the patients do not have metastasis and relapse after 8 years of survival.

4. Mr. Wang, man, born in 1962, plain county loess Liang village, diagnosed in 2018 as relapse hospitalization after brain glioma postoperative radiotherapy, 9 g of pill for benefiting qi and generating blood is given three times a day, and patients are treated by 1 degree bone marrow suppression by oral administration in combination with chemotherapy, so as to successfully finish the treatment.

5. Lie li hua, man, born in 1946. In 2009, the diagnosis shows that meningioma is unwilling to be treated by operation, 9 g of qi-tonifying and blood-generating pills are taken three times a day, and are matched with intracranial radiotherapy, and bone marrow suppression does not occur in the course of treatment.

6. Women, born in 1957. Chengde city Xinglong county large stick village. The diagnosis in 2016 is that the peritoneal metastasis of ovarian cancer is hospitalized by a large amount of abdominal dropsy, docetaxel and cisplatin are given for chemotherapy for 8 cycles, and simultaneously 9 g of qi-tonifying and blood-generating pills are taken three times a day, so that bone marrow suppression, liver and kidney function damage and relapse do not occur in the treatment process within 4 years.

7. Mr. plum, man, born in 1956. The towns of the Longding county of Chengde City. The diagnosis in 2016 years 1 is that the renal clear cell carcinoma is removed by operation in local hospitals, for the treatment of consolidation, biological immunotherapy and chemotherapy are given, 9 g of pills for benefiting qi and generating blood are taken orally three times a day, no myelosuppression occurs during the treatment period, the metastasis and relapse do not occur in 4 years of survival till now, and the life and the work are normal.

8. Mr. Zhao, Man, Chengde, Pingquan county, south fifty family Zhen ren. In 2017, in 11 months, the diagnosis shows that the MOPP scheme is applied to the multiple myeloma for 6 cycles, 9 grams of qi-tonifying and blood-generating pills are applied three times a day, and the bone marrow suppression does not occur in the oral treatment period. The consolidation treatment is carried out for 3 years without relapse.

9. Tong female, born in 1968, Chengdu city, Xinglong county, Semuran Shanzhen. The lung cancer is frequently metastasized in the lung, the right femoral head is metastasized, and paralysis can not be actively treated in the hospital in 4 months in 2015. The particle implantation therapy of femoral head local iodine 125 radiotherapy and the oral therapy of molecular target medicament Yiruisha 250mg are given, 9 g of qi-tonifying and blood-generating pills are taken for three times every day, 1 degree of marrow suppression is achieved during the treatment period, the patient can be supported to walk under the bed after 1 month of treatment, the patient can freely move after 2 months, all clinical symptoms disappear, the tumor focus disappears after 3 months of reexamination, the existing consolidation therapy of Yiruisha and Fuzheng Xiao capsule is continued, and no metastasis and relapse occur.

10. Mr. Zhang, Man, born in 1957. The 8-month diagnosis in 2014 shows that the pill is taken orally for 9 g, three times a day, has no myelosuppression and has no transfer relapse signs.

11. Mr. plum, male, born in 1972. In the diagnosis of 7 months in 2015, after the pancreatic cancer is treated by a high-energy focused ultrasound knife and is matched with chemotherapy, 9 g of qi-tonifying and blood-generating pills are orally taken for three times every day, bone marrow suppression does not occur after treatment, and no metastasis and relapse exist until now.

The clinical traditional Chinese medicine preparation for relieving the bone marrow suppression caused by the chemotherapy is used for assisting the radiotherapy and the chemotherapy to treat 10078 cases of various malignant tumors, and the clinical chemotherapy prevention and use effective rate is more than 80 percent and the use effective rate after the chemotherapy is more than 70 percent through preliminary statistics. Can obviously improve the combined clinical symptoms and improve the life quality of patients; and can reduce the chance of metastasis and relapse, is a safe and effective adjuvant therapy method, and has clinical use value. (1) The traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy overcomes all the defects of the medicines due to the side effect of the recombinant human granulocyte colony-stimulating factor, improves the physique of a patient while increasing blood, ensures the implementation of the radiotherapy and chemotherapy treatment course, can increase the curative effect of the radiotherapy and chemotherapy, and has low price, exact curative effect, convenient administration and popularization value. (2) The traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy is used for treating more than 1 ten thousand cases of patients with digestive tract reaction caused by malignant tumors, has better curative effect on treating diseases such as gastritis and gastric ulcer, preventing and treating nausea and vomiting reaction caused by chemotherapy, can increase clinical curative effect, enhance the disease resistance of human bodies, prevent transfer and relapse, and has popularization and use values.

The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.

Claims

1. A traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy is characterized by being prepared from the following medicines in parts by weight:

10-30 parts of caulis spatholobi; 20-30 parts of rhizoma drynariae; 10-30 parts of prepared fleece flower root; 20-30 parts of astragalus; 15-30 parts of malt; 20-30 parts of epimedium; 20-30 parts of ginseng; 15-30 parts of Chinese yam; 25-30 parts of prepared rhizome of rehmannia; 20-30 parts of angelica;

5-10 parts of ligusticum wallichii; 10-20 parts of bighead atractylodes rhizome.

2. The traditional Chinese medicine preparation for relieving bone marrow suppression caused by chemotherapy according to claim 1, which is prepared from the following medicines in parts by weight:

3. A method of preparing the traditional Chinese medicine preparation for alleviating bone marrow suppression caused by chemotherapy according to claim 1, which comprises the following steps: the components are proportioned according to the following parts, decocted and extracted, added with auxiliary materials and refined into water pills;