CN103784802B - A kind of Chinese medicine composition for the treatment of diabetes - Google Patents

Abstract

The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes, it is made up of medical materials such as Radix Angelicae Sinensis, Radix Puerariae, Radix Ginseng, Rhizoma Dioscoreae, Herba Cymbopogonis Citrari, Radix Sophorae Tonkinensiss.The Chinese medicine composition for the treatment of diabetes of the present invention carries out scientific compatibility, meticulously filter out multidigit Chinese crude drug, carry out scientific compatibility, effectively can treat diabetes, the scientific formula of the present composition, compatibility is reasonable, therapeutic effect is obvious, have safe and reliable, have no side effect, patient such as to take like a shot at the feature.

Description

A kind of Chinese medicine composition for the treatment of diabetes

Technical field

The present invention relates to tcm field, specifically, relate to a kind of Chinese medicine composition for the treatment of diabetes.

Background technology

Diabetes have become a kind of global disease at present, and have the trend risen further, and wherein type 2 diabetes mellitus accounts for 90%-95%.The daily main therapeutic modality of major part type 2 diabetes mellitus patient controls blood glucose, but, even if by existing multiple oral drug therapy and control, the glycemic control that current China still has the patient more than 70% cannot reach desirable.The weak point of Traditional regimen comprise put on weight, risk of hypoglycemia, gastrointestinal untoward reaction.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of diabetes.

In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of diabetes, it is made up of the material of following weight proportioning: Radix Angelicae Sinensis 2 parts, Radix Puerariae 2 parts, Radix Ginseng 8 parts, Cor Cervi grass 25 parts, the Radix Astragali 13 parts, Galla Chinensis 13 parts, Hirudo 13 parts, fly grass 20 parts, Rhizoma Dioscoreae 13 parts, Cortex Mori 13 parts, 8 parts, Semen phaseoli radiati, Semen Litchi 13 parts, Herba Euphorbiae Humifusae 8 parts, Herba Catharanthi Rosei 8 parts, Ramulus Euonymi 8 parts, Rhizoma Coptidis 13 parts, Fructus Corni 8 parts, Herba Agrimoniae 8 parts, Radix seu Herba Pegaeophytonis Scapiflori 30 parts, 8 parts, Herba Cymbopogonis Citrari, 2 parts, Semen sojae atricolor, Rhizoma Chuanxiong 2 parts, Carapax et Plastrum Testudinis 2 parts, Carapax Trionycis 2 parts, Rhizoma Paridis 2 parts, Radix Sophorae Tonkinensis 2 parts, Herba Moslae 2 parts, Fructus Broussonetiae 2 parts, the Rhizoma Atractylodis Macrocephalae 2 parts, Rhizoma Alismatis 2 parts, Stigma Maydis 2 parts, Radix Ophiopogonis 2 parts, Endothelium Corneum Gigeriae Galli 5 parts, Rhizoma Atractylodis 5 parts, grass dragon 25 parts, 5 parts, the Radix Rehmanniae, the Rhizoma Anemarrhenae 5 parts, Pollen Pini 5 parts, Fructus Lycii 5 parts, 5 parts, Semen Persicae, Radix Codonopsis 5 parts, Radix Platycodonis 5 parts, Radix Scrophulariae 5 parts, Semen Astragali Complanati 5 parts and Cordyceps 2 parts.

Preferably, described medicine can be tablet, dispersible tablet, powder, rapidly dissolving tablet, unguentum or decoction.

In the present compositions, Cor Cervi grass (Classification system: BalanophoradioicaR.Br.exRoyle [B.affinisGriff.]) nature and flavor are bitter, puckery, warm in nature, have kidney invigorating and YANG supporting, the effect such as spleen invigorating is regulated the flow of vital energy, hemostasis; Fly grass (Classification system SilenegallicaLinn.) nature and flavor are pungent, puckery, cool, have clearing away heat-damp and promoting diuresis, the effects such as removing toxic substances and promoting subsidence of swelling; Radix seu Herba Pegaeophytonis Scapiflori (Classification system RadixseuHerbaPegaeophytonisScapiflori) nature and flavor acrid in the mouth, pungent, cold in nature, there is the effects such as heat-clearing and toxic substances removing, hemostasis, detumescence; Grass dragon (Classification system LudwigialinifoliaPoir.) nature and flavor are light, cool, and have the effect such as heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation, above-mentioned medical material is monarch drug.Radix Astragali nature and flavor are sweet, tepor, have the effects such as benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, holder skin ulcer granulation promoting, inducing diuresis to remove edema; Hirudo nature and flavor are salty, bitter, flat, for what lump in the abdomen, blood stasis amenorrhea and traumatic injury etc.; Galla Chinensis nature and flavor are sour, puckery, cold, for chronic cough of deficiency lung, and lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quenches one's thirst; Rhizoma Dioscoreae nature and flavor are sweet flat, have the effect such as supplementing QI and nourishing YIN, spleen reinforcing lung kidney; Cortex Mori nature and flavor are sweet, cold, have the effect such as eliminating pathogen from the lung for relieving asthma, line water detumescence; Semen Litchi (Classification system SEMENLITCHI) sweet in flavor and warm in property, micro-hardship, has the effect such as promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving; Rhizoma Coptidis nature and flavor are bitter, cold, and be usually used in the damp and hot caused card such as diarrhoea, dysentery, vomiting of the intestines and stomach, above-mentioned medical material is ministerial drug.Ramulus Euonymi (Classification system Euonymusalatus) nature and flavor bitter, acrid, cold, have the effects such as removing blood stasis stimulates the menstrual flow, removing toxic substances and promoting subsidence of swelling, parasite killing; Herba Euphorbiae Humifusae nature and flavor are pungent, flat, the effect such as there is heat-clearing and toxic substances removing, dampness removing jaundice eliminating, invigorate blood circulation; Semen phaseoli radiati sweet in the mouth is cold in nature, the thick the intestines and stomach of energy, profit skin, the five internal organs and taste taste; Radix Ginseng sweet and slightly bitter taste, can strongly invigorating primordial QI, invigorating the spleen to benefit the lung, has promoting the production of body fluid to quench thirst, effects such as Fructus Alpiniae Oxyphyllae of calming the nerves; Herba Catharanthi Rosei property mildly bitter flavor is cool, has the effects such as suppressing the hyperactive liver and subsiding YANG, antitumor, tranquillizing and allaying excitement, diuresis; Fructus Corni nature and flavor are sour, puckery, tepor, have the effect such as liver and kidney tonifying, essence astringing and desertion stemming; Herba Agrimoniae nature and flavor are pained and put down, and have the effects such as astringing to arrest bleeding, tonify deficiency, removing food stagnancy, dysentery relieving; Herba Cymbopogonis Citrari (Classification system MoslachinensisMaxim) nature and flavor are pungent, warm, and have dispelling wind to relieve the exterior syndrome, wind-damp dispelling, loose cool effect such as cold, above-mentioned medical material is adjuvant drug.Radix Angelicae Sinensis nature and flavor sweet in the mouth, pungent, warm in nature, for heart-liver blood deficiency, shallow complexion, dizzy cardiopalmus etc.; Radix Puerariae nature and flavor are sweet, pungent, cool, have relieving muscles diaphoresis, invigorating YANG QI to promote eruption, antipyretic effect such as to promote the production of body fluid; Semen sojae atricolor nature and flavor are sweet, flat, have invigorate blood circulation, diuretic, dispel the wind, the effect such as heat-clearing and toxic substances removing; Rhizoma Chuanxiong nature and flavor are pungent, warm, have the effect such as blood-activating and qi-promoting, wind-expelling pain-stopping; The effects such as Carapax et Plastrum Testudinis nature and flavor are salty, sweet, flat, have YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone; Carapax Trionycis nature and flavor are salty, are slightly cold, and have nourishing YIN for suppressing the hyperactive YANG,

Hard masses softening and resolving, brings down a fever except effects such as steamings; Rhizoma Paridis nature and flavor are slightly cold, bitter in the mouth, have the effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the arresting convulsion of cool liver; Radix Sophorae Tonkinensis nature and flavor bitter cold, has the effect such as heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling; Herba Moslae (Classification system Elsholtziaciliata (Thunb.) Hyland.) nature and flavor are pungent, and tepor, has merit and arrogate to oneself diaphoresis expelling summer-heat, row water wet dissipation, and stomach warming adjusts medium effect; Fructus Broussonetiae is cold in nature, sweet in the mouth, has the effects such as the kidney invigorating liver heat removing, improving eyesight, diuresis; Rhizoma Atractylodis Macrocephalae nature and flavor are bitter, sweet, warm, have invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, the effect such as antiabortive; Rhizoma Alismatis is sweet in flavor and cold in property, has the effects such as patent water channel, infiltration be wet; Stigma Maydis nature and flavor are sweet flat, have diuresis, expel the heat-evil, effect of suppressing the hyperactive liver, function of gallbladder promoting; Sweet, the micro-hardship of nature and flavor Radix Ophiopogonis, be slightly cold, for dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation; Endothelium Corneum Gigeriae Galli is hidden and is returned through sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel, it is stagnant that function cures mainly removing food stagnancy, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha; Rhizoma Atractylodis nature and flavor acrid in the mouth, hardship, warm in nature, fragrance is dry strong, interior can turbid strongly fragrant of removing dampness, external enwergy is fallen apart the heresy of rheumatism, therefore can be drying damp and strengthening spleen, expelling wind and removing dampness; Radix Rehmanniae sweet in the mouth bitterness Great Cold, there is the effects such as YIN nourishing, clearing away heat and promoting production of body fluid, cooling blood for hemostasis; Rhizoma Anemarrhenae nature and flavor bitter cold and not dry, has the effects such as clearing away stomach-heat; Pollen Pini (Pollen Pini is the pollen of pinaceae plant Pinus massoniana Lamb, Pinus tabuliformis or its congener) nature and flavor are sweet, and temperature, has QI invigorating of dispeling the wind, removing dampness, the effects such as hemostasis; Fructus Lycii sweet in the mouth, property is put down, and has the effect such as nourishing the liver and kidney, replenishing vital essence to improve eyesight; Sweet flat, the bitter in the mouth of Semen Persicae, has blood stasis removing and clots absorbing, moisturizes effect of laxation; Radix Codonopsis nature and flavor are sweet flat, and main function is air making-up and spleen enlivening; Radix Platycodonis bitter in the mouth, pungent, property are put down, and have lung qi dispersing, sore-throat relieving, eliminate the phlegm, the effect such as evacuation of pus; Radix Scrophulariae nature and flavor sweetness and bitterness is salty to be slightly cold, and has clearing away heat and cooling blood, YIN nourishing, effect of eliminating fire and detoxication; Semen Astragali Complanati nature and flavor are sweet, warm, have the effects such as liver and kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight; Cordyceps nature and flavor sweet in the mouth, warm in nature, have foster lung yin, kidney-replenishing, relieving cough and resolving phlegm, anticancer anti-old effect, above-mentioned medical material is for making medicine.So medical material plays drug effect jointly according to the principle of monarch.

The Chinese medicine composition for the treatment of diabetes of the present invention carries out scientific compatibility, meticulously filter out multidigit Chinese crude drug, carry out scientific compatibility, effectively can treat diabetes, the scientific formula of the present composition, compatibility is reasonable, therapeutic effect is obvious, have safe and reliable, have no side effect, patient such as to take like a shot at the feature.

Detailed description of the invention

Embodiment:

Take Radix Angelicae Sinensis 20 grams, Radix Puerariae 20 grams, Radix Ginseng 80 grams, Cor Cervi grass 250 grams, the Radix Astragali 130 grams, Galla Chinensis 130 grams, Hirudo 130 grams, fly grass 200 grams, Rhizoma Dioscoreae 130 grams, Cortex Mori 130 grams, 80 grams, Semen phaseoli radiati, Semen Litchi 130 grams, Herba Euphorbiae Humifusae 80 grams, Herba Catharanthi Rosei 80 grams, Ramulus Euonymi 80 grams, Rhizoma Coptidis 130 grams, Fructus Corni 80 grams, Herba Agrimoniae 80 grams, Radix seu Herba Pegaeophytonis Scapiflori 300 grams, 80 grams, Herba Cymbopogonis Citrari, 20 grams, Semen sojae atricolor, Rhizoma Chuanxiong 20 grams, Carapax et Plastrum Testudinis 20 grams, Carapax Trionycis 20 grams, Rhizoma Paridis 20 grams, Radix Sophorae Tonkinensis 20 grams, Herba Moslae 20 grams, Fructus Broussonetiae 20 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Rhizoma Alismatis 20 grams, Stigma Maydis 20 grams, Radix Ophiopogonis 20 grams, Endothelium Corneum Gigeriae Galli 50 grams, Rhizoma Atractylodis 50 grams, grass dragon 250 grams, 50 grams, the Radix Rehmanniae, the Rhizoma Anemarrhenae 50 grams, Pollen Pini 50 grams, Fructus Lycii 50 grams, 50 grams, Semen Persicae, Radix Codonopsis 50 grams, Radix Platycodonis 50 grams, Radix Scrophulariae 50 grams, Semen Astragali Complanati 50 grams and Cordyceps 20 grams, pulverize, cross 100 mesh sieves, add lactose 50 grams, be dispensed in 300 bags, obtain powder of the present invention.

Experimental example

Physical data

Type 2 diabetes mellitus patient 40 example selected outpatient service and be in hospital, diabetes meet the 2 type glycosuria diagnostic criterias that WHO formulates in 1999.Be divided into 2 groups, treatment group 20 example, wherein man 10 example, female 10 example, the age (56 ± 6) year, diabetic duration 2-10; Matched group 20 example, wherein man 9 example, female 11 example, the age (57 ± 5) year, diabetic duration 2-11.2 groups of no significant difference on age, sex, severity extent (P > 0.05), have comparability.

2 groups of patients all carry out health education in diabetes, and diabetic diet and appropriate exercise, treatment group adopts the powder prepared in embodiment to treat, and oral 2 times of every day, oral one bag at every turn, treats 3 months.Matched group adopts phosphoric acid sitagliptin to treat, and every day 1 time, each oral 100mg, treats 3 months.

Testing index

Detect 2 groups in the treatments period fasting glucose of every 2 weeks (FBG), after the meal 2 hours blood glucoses (2-hPPG), HbAlc, hypoglycemia incidence rate, body weight change situation.

Statistical procedures

Measurement data mean ± standard deviation represents, compares and adopts t inspection, use SPSS12.0 statistics software between group, and P < 0.05 has significant difference for statistics.

Treatment group is better than matched group (P < 0.05) in glycemic control; Matched group (P < 0.05) is better than in reduction HbAlc; Treatment group is better than matched group (P < 0.05) in the risk reducing hypoglycemia and body weight increase.In table 1.

Front and back fasting glucose, after the meal 2 hours blood glucoses, HbA are treated in the smelting of table 12 group _1c, hypoglycemia incidence rate, body weight change situation compare (mean ± standard deviation)

Untoward reaction is observed

At treatments period, following monitoring is carried out to patient, find the no abnormality seen result such as each group of blood, defecation routine, electrocardiogram, hepatic and renal function inspection.

Claims (1)

1. treat a powder for diabetes, it is characterized in that, it is made by following method: take Radix Angelicae Sinensis 20 grams, Radix Puerariae 20 grams, Radix Ginseng 80 grams, Cor Cervi grass 250 grams, the Radix Astragali 130 grams, Galla Chinensis 130 grams, Hirudo 130 grams, fly grass 200 grams, Rhizoma Dioscoreae 130 grams, Cortex Mori 130 grams, 80 grams, Semen phaseoli radiati, Semen Litchi 130 grams, Herba Euphorbiae Humifusae 80 grams, Herba Catharanthi Rosei 80 grams, Ramulus Euonymi 80 grams, Rhizoma Coptidis 130 grams, Fructus Corni 80 grams, Herba Agrimoniae 80 grams, Radix seu Herba Pegaeophytonis Scapiflori 300 grams, 80 grams, Herba Cymbopogonis Citrari, 20 grams, Semen sojae atricolor, Rhizoma Chuanxiong 20 grams, Carapax et Plastrum Testudinis 20 grams, Carapax Trionycis 20 grams, Rhizoma Paridis 20 grams, Radix Sophorae Tonkinensis 20 grams, Herba Moslae 20 grams, Fructus Broussonetiae 20 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Rhizoma Alismatis 20 grams, Stigma Maydis 20 grams, Radix Ophiopogonis 20 grams, Endothelium Corneum Gigeriae Galli 50 grams, Rhizoma Atractylodis 50 grams, grass dragon 250 grams, 50 grams, the Radix Rehmanniae, the Rhizoma Anemarrhenae 50 grams, Pollen Pini 50 grams, Fructus Lycii 50 grams, 50 grams, Semen Persicae, Radix Codonopsis 50 grams, Radix Platycodonis 50 grams, Radix Scrophulariae 50 grams, Semen Astragali Complanati 50 grams and Cordyceps 20 grams, pulverize, and crosses 100 mesh sieves, add lactose 50 grams, be dispensed in 300 bags, obtain final product.