CN113332326A - Traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and preparation method thereof - Google Patents

Traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and preparation method thereof Download PDF

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CN113332326A
CN113332326A CN202110659826.9A CN202110659826A CN113332326A CN 113332326 A CN113332326 A CN 113332326A CN 202110659826 A CN202110659826 A CN 202110659826A CN 113332326 A CN113332326 A CN 113332326A
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倪军
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Zhangjiagang Hospital of Traditional Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses a traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and a preparation method thereof, wherein the traditional Chinese medicine composition comprises 25-30 parts of astragalus mongholicus, 5-15 parts of angelica sinensis, 5-15 parts of bighead atractylodes rhizome, 15-25 parts of sun-dried ginseng, 5-15 parts of ligusticum wallichii and 15-25 parts of epimedium herb. The preparation method comprises the following steps: weighing the traditional Chinese medicine components, and soaking in water; decocting the soaked materials, boiling for 20-30min, and collecting the first decoction; adding the same water amount as the first decoction into the Chinese medicinal materials, decocting for the second time under the same conditions as the first decoction, and collecting the second decoction; and combining the first decoction and the second decoction to obtain the Chinese medicinal composition. The traditional Chinese medicine composition has the effects of tonifying qi and producing blood, is mainly used for treating the symptoms of overstrain internal injury and deficiency of qi and blood, and is particularly suitable for the conditions of leucopenia, anemia and the like after chemotherapy. The traditional Chinese medicine composition provided by the invention is reasonable and scientific in compatibility, low in price and good in treatment effect.

Description

Traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and a preparation method thereof.
Background
Myelosuppression refers to a decrease in the activity of blood cell precursors in the bone marrow. Both red blood cells and white blood cells in the bloodstream originate from stem cells in the bone marrow. Blood cells in the bloodstream have a short life span and often require constant replenishment. For the purpose of timely replenishment, stem cells, which are precursors of blood cells, must divide rapidly. Chemotherapy (Chemotherapy) and radiation therapy (radiation), as well as many other antineoplastic therapies, are directed against rapidly dividing cells, often resulting in the suppression of normal bone marrow cells. Therefore, myelosuppression is a common toxic reaction of most chemotherapeutic drugs, most chemotherapeutic drugs can cause myelosuppression with different degrees, so that the number of peripheral blood cells is reduced, the blood cells are composed of a plurality of components, each component plays an indispensable role on a human body, and the reduction of any component causes the corresponding side reaction of the body. Therefore, it is very necessary to provide a Chinese medicinal composition for relieving bone marrow suppression to improve the leucopenia, anemia and other conditions of patients.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and a preparation method thereof, aiming at relieving the adverse condition of bone marrow suppression after chemotherapy.
The invention adopts the following technical scheme.
A traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy comprises the following components in parts by weight: 25-30 parts of astragalus membranaceus, 5-15 parts of angelica sinensis, 5-15 parts of bighead atractylodes rhizome, 15-25 parts of sun-dried ginseng, 5-15 parts of ligusticum wallichii and 15-25 parts of epimedium herb.
Further, the traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy comprises the following components in parts by weight: 30 parts of astragalus, 10 parts of angelica, 10 parts of bighead atractylodes rhizome, 20 parts of sun-dried ginseng, 10 parts of ligusticum wallichii and 20 parts of epimedium herb.
A preparation method of a traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy comprises the following steps:
s1, weighing prescribed amounts of radix astragali, angelica, bighead atractylodes rhizome, sun-dried ginseng, ligusticum wallichii and herba epimedii, soaking in water, adding water to submerge the medicine surface for 2-3cm, and soaking for 20-40 min;
s2, decocting the soaked medicinal materials, boiling for 20-30min, and collecting a first decoction;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
and S4, combining the first decoction and the second decoction to obtain the Chinese herbal medicine.
Further, in step S1, the temperature of the water for soaking the traditional Chinese medicine is 25-50 ℃.
The present invention obtains the following advantageous effects.
The astragalus membranaceus in the traditional Chinese medicine composition is mild in blood enriching, particularly for people with spleen and stomach weakness, the medicine property is mild, and the situation that deficiency is not compensated is not easy to occur; the biggest characteristic of angelica for enriching blood is that the angelica can not only enrich blood but also activate blood. The astragalus mongholicus and angelica sinensis are prepared according to the proportion disclosed by the application, have the effects of tonifying qi and producing blood, are mainly used for treating the symptoms of overstrain internal injury and deficiency of qi and blood, and are particularly suitable for the conditions of leucopenia, anemia and the like after chemotherapy. The traditional Chinese medicine composition provided by the invention is reasonable and scientific in compatibility, low in price, good in treatment effect and suitable for clinical popularization.
Detailed Description
The present invention will be further described with reference to examples.
Example 1
A preparation method of a traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy comprises the following steps:
s1, weighing 25g of astragalus membranaceus, 15g of angelica sinensis, 5g of bighead atractylodes rhizome, 25g of sun-dried ginseng, 5g of ligusticum wallichii and 25g of epimedium, soaking in water, soaking for 40min when the water level is 25 ℃ and the medicine surface is submerged by 2 cm;
s2, decocting the soaked medicinal materials, keeping the medicinal materials in a slightly boiling state with strong fire when the medicinal materials are not boiled and with slow fire after the medicinal materials are boiled, boiling for 20min, and collecting first decoction liquid; the best utensil for decocting the medicines is a marmite, a ceramic pot or a stainless steel pot;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
and S4, combining the first decoction and the second decoction to obtain the Chinese herbal medicine.
Example 2
A preparation method of a traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy comprises the following steps:
s1, weighing 30g of astragalus membranaceus, 5g of angelica sinensis, 15g of bighead atractylodes rhizome, 15g of sun-dried ginseng, 15g of ligusticum wallichii and 15g of epimedium herb, soaking in water, soaking for 20min when the water level is 50 ℃ and the medicine surface is submerged by 3 cm;
s2, decocting the soaked medicinal materials, keeping the medicinal materials in a slightly boiling state with strong fire when the medicinal materials are not boiled and with slow fire after the medicinal materials are boiled, boiling for 30min, and collecting first decoction liquid; the best utensil for decocting the medicines is a marmite, a ceramic pot or a stainless steel pot;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
and S4, combining the first decoction and the second decoction to obtain the Chinese herbal medicine.
Example 3
A preparation method of a traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy comprises the following steps:
s1, weighing 30g of astragalus membranaceus, 10g of angelica sinensis, 10g of bighead atractylodes rhizome, 20g of sun-dried ginseng, 10g of ligusticum wallichii and 20g of epimedium herb, soaking in water, soaking for 30min when the water level is 2cm higher than the medicine surface, and keeping the water temperature at 40 ℃;
s2, decocting the soaked medicinal materials, keeping the medicinal materials in a slightly boiling state with strong fire when the medicinal materials are not boiled and with slow fire after the medicinal materials are boiled, boiling for 20min, and collecting first decoction liquid; the best utensil for decocting the medicines is a marmite, a ceramic pot or a stainless steel pot;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
and S4, combining the first decoction and the second decoction to obtain the Chinese herbal medicine.
Clinical cases
Case 1: wangzhi, female, 60 years old. The diagnosis is completed within 2 months after the chemotherapy is finished. The patients have no history of chronic diseases and are thin in body. The patient can be diagnosed with right lung adenocarcinoma IV by lung puncture, and the AP venous chemotherapy is performed for 1 time in the hospital, and the patient has bone marrow depression, poor appetite, short breath after the chemotherapy, pale tongue, thin fur, white pulse and thready pulse after the exercise. The routine of blood examination in outpatient service: the total number of leucocytes is 2.58 x 10^9/L, the number of neutrophils is 1.06 x 10^9/L, the hemoglobin is 103.0 g/L, and the number of platelets is 88 x 10^ 9/L. The 5-dose decoction of the traditional Chinese medicine decoction prepared in the embodiment 3 of the application is decocted and taken, and the decoction is preferably taken 1 hour before meals; 1 dose of the medicine is taken for 2 times; concentrated tea and radix Raphani should not be used during administration of the Chinese medicinal composition. After the pill is taken, the appetite of a patient is improved, the shortness of breath and the fatigue are improved, and the patient can sleep. After 5 doses are taken, the blood routine is rechecked: total white blood cell count 5.32 x 10^9/L, neutrophil 3.06 x 10^9/L, hemoglobin 112.0 g/L, platelet count 96 x 10^ 9/L. Effectively relieve the bone marrow suppression after chemotherapy and relieve the pain of patients.
Case 2: lie, male, 66 years old. The main cause of the disease is 'cough, shortness of breath and hypodynamia for more than 1 month'. The patient smokes plain, the previous hypertension history shows that in nearly 1 month, irritable cough gradually occurs, chest distress and short breath are accompanied, poor appetite and poor hair strength are accompanied, the weight is reduced recently, the tongue is light, the tongue is thin, the tongue is provided with tooth marks at the edges, and the pulse is thin. Clearly diagnosing the IIIB stage of the left lung squamous carcinoma, performing TC (albumin paclitaxel + carboplatin) chemotherapy, inhibiting bone marrow after chemotherapy, aggravating shortness of breath and debilitation, inducing insomnia after anorexia and insomnia, and performing blood-checking routine after chemotherapy for 72 hours: total leukocyte count 3.06 x 10^9/L, neutrophil 1.25 x 10^9/L, hemoglobin 110.0 g/L, platelet count 126 x 10^ 9/L. The 5-dose decoction of the traditional Chinese medicine decoction prepared in the embodiment 1 of the application is decocted and taken, and the decoction is preferably taken 1 hour before meals; 1 dose of the medicine is taken for 2 times; concentrated tea and radix Raphani should not be used during administration of the Chinese medicinal composition. After the medicine is taken, the shortness of breath and hypodynamia of patients are obviously improved, and the patients can take the medicine for sleep. After 5 doses are taken, the blood routine is rechecked: total leukocytes 5.18 x 10^9/L, neutrophils 3.25 x 10^9/L, hemoglobin 112.0 g/L, platelet count 130 x 10^ 9/L. Effectively relieve the bone marrow suppression after chemotherapy, improve the clinical symptoms of deficiency of qi and blood of patients and relieve the pain of the patients.
The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.

Claims (4)

1. A traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy is characterized in that: the paint comprises the following components in parts by weight: 25-30 parts of astragalus membranaceus, 5-15 parts of angelica sinensis, 5-15 parts of bighead atractylodes rhizome, 15-25 parts of sun-dried ginseng, 5-15 parts of ligusticum wallichii and 15-25 parts of epimedium herb.
2. The traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy according to claim 1, which is characterized in that: the paint comprises the following components in parts by weight: 30 parts of astragalus, 10 parts of angelica, 10 parts of bighead atractylodes rhizome, 20 parts of sun-dried ginseng, 10 parts of ligusticum wallichii and 20 parts of epimedium herb.
3. A method for preparing a Chinese medicinal composition for relieving post-chemotherapy myelosuppression as claimed in any one of claims 1-2, which is characterized by comprising the following steps: the method comprises the following steps:
s1, weighing prescribed amounts of radix astragali, angelica, bighead atractylodes rhizome, sun-dried ginseng, ligusticum wallichii and herba epimedii, soaking in water, adding water to submerge the medicine surface for 2-3cm, and soaking for 20-40 min;
s2, decocting the soaked medicinal materials, boiling for 20-30min, and collecting a first decoction;
s3, adding the same water amount as the first decoction into the traditional Chinese medicine, carrying out second decoction under the same condition as the first decoction, and collecting liquid medicine of the second decoction;
and S4, combining the first decoction and the second decoction to obtain the Chinese herbal medicine.
4. The preparation method of the traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy, according to claim 3, is characterized in that: in step S1, the temperature of the water for soaking the traditional Chinese medicine is 25-50 ℃.
CN202110659826.9A 2021-06-15 2021-06-15 Traditional Chinese medicine composition for relieving bone marrow suppression after chemotherapy and preparation method thereof Pending CN113332326A (en)

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CN116549584A (en) * 2023-05-23 2023-08-08 天津市肿瘤医院(天津医科大学肿瘤医院) Traditional Chinese medicine composition for treating bone marrow suppression and preparation method thereof

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CN116549584A (en) * 2023-05-23 2023-08-08 天津市肿瘤医院(天津医科大学肿瘤医院) Traditional Chinese medicine composition for treating bone marrow suppression and preparation method thereof
CN116549584B (en) * 2023-05-23 2024-01-19 天津市肿瘤医院(天津医科大学肿瘤医院) Traditional Chinese medicine composition for treating bone marrow suppression and preparation method thereof

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Application publication date: 20210903