CN1085082C - Recipe of Fumailing for curing arrhythmic coronary heart disease and producing method - Google Patents
Recipe of Fumailing for curing arrhythmic coronary heart disease and producing method Download PDFInfo
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- CN1085082C CN1085082C CN93101423A CN93101423A CN1085082C CN 1085082 C CN1085082 C CN 1085082C CN 93101423 A CN93101423 A CN 93101423A CN 93101423 A CN93101423 A CN 93101423A CN 1085082 C CN1085082 C CN 1085082C
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Abstract
The present invention relates to the prescription and the production method of a medicine for treating coronary disease, particularly to arrhythmic coronary disease. In the production method, fine berberine powder is added to liquid medicine prepared by decocting astragalus root, ginseng, notoginseng, hawthorn fruit, safflower, red peony root, ganoderma, red sage root, pubescent angelica root snakegourd root powder, prepared liauorice root, kudzuvine root, fleece-flower root, finger citron, prepared nutgrass galingale rhizome, ophiopogon root, Chinese box twig, lightyellow sophora root, schisandra fruit and cattail pollen to be uniformly mixed, granulated, dried and encapsulated. Tests prove that an obtained medicine has the advantages of no toxicity, and very ideal short-term therapeutic effect and long-term therapeutic effect.
Description
The present invention relates to a kind ofly to treat coronary heart disease, particularly arrhythmia type coronary heart disease, all with the prescription and the production method of the medicine of Chinese medicine preparation.
Coronary atherosclerotic heart disease is called for short coronary heart disease, and the sickness rate in total population is 7～9%, and is then higher person in middle and old age, is the main cause that causes sudden death clinically.Before the present invention occurs, the Chinese medicine and western medicine of treatment coronary heart disease has: diabetes with polydipsia as the prominent symptom disease, nifedipine, persantin, second be flushed with drink iodine skin ketone, diltiazem, slow heart rate, propranolol, propafenone, quinidine, the live heart, SUXIAO JIUXIN WAN, FUFANG DANSHEN PIAN, XIONGDAN JIUXINWAN, storax pill for treating coronary heart disease, NAOXINSHU etc., these medicines are because of all being to pass through blood vessel dilating on pharmacology, temporarily solve the blood supply problem, so short term efficacy is in various degree all arranged, but there is not late result, do not reach the purpose of healing at all, and take the drug resistance that all has in various degree for a long time and pay the effect generation.
The prescription and the production method that the purpose of this invention is to provide a kind of novel medicine, the medicine that produces according to this method has late result again and finally reaches the healing purpose the existing short term effect of the treatment of coronary heart disease, and does not have the effect of paying of any poison and produce.
The present invention is the new pharmacological action that the qi-blood relationship theory learned according to Chinese traditional medicine and modern medicine are found various institutes of Chinese materia medica, according to " principle of strengthening vital QI to eliminate pathogenic factors ＂ is finished for symptomatic treatment in acute condition; radical treatment in chronic case; set upright based on reinforcing; ｀ lead to ' just must not hinder; ｀ mend ' must not be detained, giving consideration to both the incidental and fundamental.
Chinese medicine is thought: the pathogenesis of coronary heart disease generation, many owing to worn with age, deficiency of kidney-QI, and kidney is people's a Yuanyang Kidney-Yin, so further developing, pectoral qi void can cause also void of kidney yang, further develop again and can cause also void of kidney yin, cause kidney Yuanyang Kidney-Yin two to lose intemperance of taking food, impairing the spleen and stomach, cause deficiency-weakness of spleen-QI, the biochemical general source of pectoral qi, water is wet to be lost in fortuneization, turbid damp is detained in the heart, internal injury caused by excess of seven emotions, qi depression to blood stasis, because of insufficiency of pectoral QI to pass through heart arteries and veins promoting the circulation of blood gas, and the hyperamization row is unfavorable, even blood-stasis internal-depression is pondered over overstrain, injure heart spleen.Or invade outside the heresy poison, the interior house in the heart, consumption impairment of QI the moon, heart arteries and veins loses foster and causes arrhythmia; Or direct stimulation, seven emotions discord, qi depression to blood stasis, blockage of the cardiac vessels, conduction abnormalities; Or deficiency of heart-QI or flaccidity of the heart-yang, it is unable to beat, and blood is not supported network, and arteries and veins gas can not normally be connected.The present invention follows the theory of Chinese medical science determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, in cube, pays attention to the beneficial motive, the blood that nourishes heart, blood circulation promoting and blood stasis dispelling, a surname promotes blood circulation network to play multiple feeling pulse merit, on flavour of a drug are accepted or rejected, note absorbing the modern scientific research achievement, select to have the Radix Sophorae Flavescentis of better antiarrhythmic effect, medicines such as Rhizoma Coptidis, Radix Angelicae Pubescentis.Radix Ginseng removes has reinforce functional activities of the heart, adjusts central nervous system function, adjusts endocrine and immunologic function, enhancing body promotes positive nitrogen balance, blood sugar lowering and blood fat to the defense function of various destructive stimuluses, the heart tonifying coronary dilating strengthens coronary flow and myocardial oxygen delivery, prevents the generation and the development of coronary heart disease.The Radix Astragali can strengthen myocardial contraction, improves cardiac function, and arrhythmia improves blood flow, mediation microcirculation, blood sugar lowering, protection arterial endothelial cell.Fructus Crataegi, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Notoginseng, Radix Polygoni Multiflori, Ganoderma etc., has the function that blood circulation promoting and blood stasis dispelling improves high blood coagulation state, can significantly improve hemorheological property, reduce blood viscosity, microcirculation improvement, improve internal organs amount of blood supply and body's immunity, improve physical stress ability and resisting fatigue, cold tolerance and coronary dilating, improve myocardial nutrition, strengthen hypoxia-bearing capability, arrhythmia, blood pressure lowering, blood fat reducing etc.Blood fat reducing etc.Radix Paeoniae Rubra energy blood circulation promoting and blood stasis dispelling, pain relieving.Radix Glycyrrhizae Preparata, Radix Sophorae Flavescentis can strengthen myocardial hypoxia tolerance, Rhizoma Coptidis energy coronary dilating, and coronary blood flow increasing, arrhythmia especially has better effect to grand arrhythmia on chamber property or the chamber, all can achieve good results to recurrent premature ventricular beat, premature ventricular beat.In addition, also have effects such as blood pressure lowering, blood fat reducing and blood sugar lowering.Radix Angelicae Pubescentis is used for unobstructed blood vessels, and recent studies has stronger antiarrhythmic effect.
The present invention realizes as follows.
At first select medicine by following prescription:
Radix Astragali 2000-3000g Radix Ginseng 300-500g
Radix Notoginseng 500-800g Fructus Crataegi 2000-3000g
Flos Carthami 300-450g Fructus Citri Sarcodactylis 300-450g
Radix Paeoniae Rubra 400-650g Rhizoma Cyperi (processed) 500-650g
Ganoderma 400-550g 400-450g Radix Ophiopogonis
Radix Salviae Miltiorrhizae 500-650g berberine 300-550g
Radix Angelicae Pubescentis 400-650g Ramulus Buxi Sinicae 400-850g
Radix Trichosanthis 500-550g Radix Sophorae Flavescentis 400-650g
Radix Glycyrrhizae Preparata 600-850g Fructus Schisandrae Chinensis 300-450g
Radix Puerariae 600-850g sheep Huo Ye 300-450g
Radix Polygoni Multiflori 300-450g Pollen Typhae 300-450g
Berberine in the above-mentioned prescription is broken into fine powder, other 21 flavor medicine is decocted with water, in the gained medicinal liquid, add 95% ethanol and make it to contain the alcohol amount and reach 60%, the post precipitation recovered alcohol, in spissated medicinal liquid, add the berberine powder, granulate behind the mixing, dry, pack No. 0 capsule into promptly.
Embodiment:
(1) gets Radix Astragali 2200g by above-mentioned prescription, Radix Notoginseng, each 500g of Radix Ginseng, Fructus Crataegi 2200g Flos Carthami, Radix Angelicae Pubescentis, Radix Polygoni Multiflori, Fructus Citri Sarcodactylis, Radix Ophiopogonis, Ramulus Buxi Sinicae, Radix Sophorae Flavescentis, Fructus Schisandrae Chinensis, sheep Huo Ye, each 400-600g of Pollen Typhae, Radix Paeoniae Rubra, Radix Trichosanthis, each 520g of Ganoderma, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Puerariae, each 620g of Rhizoma Cyperi (processed), add water 25000ml and in a container, decocted 3 hours, decocted the postpone that cools, get medicinal residues 1 and medicinal liquid 1 after filtration.(2) medicinal residues 1 and water 15000ml were decocted 2 hours in same container, cool postpone filter medicinal residues 2 and medicinal liquid 2.(3) medicinal residues 2 and water 10000ml are decocted in same container, cool postpone filter medicinal residues 3 and medicinal liquid 3.(4) merge medicinal liquid 1, medicinal liquid 2, medicinal liquid 3.(5) medicinal liquid is concentrated into the thick paste shape.(6) in medicinal liquid, add 95% ethanol, make it to contain the alcohol amount and reach 60% and precipitate 24 hours.(7) recovered alcohol.(8) the berberine fine powder is added mixing in the concentrated medicament.(9) granulate.(10) the graininess medicine is dried.(11) the medicine grain is sieved after, the capsule of packing into No. 0.
The gained medicine is through testing identity as stated above, medicine stable performance, avirulence.Shaanxi Province Department of Public Health entrusts Xi'an traditional Chinese medical science multidisciplinary research institute of the Second Artillery Force, the diagnostic criteria of drafting according to International Society of Cardiology in 1979 and cooperative association and World Health Organization's clinical name standardization associating special topic group, select arrhythmia type coronary heart disease 100 examples to treat at random, from in February, 992 in January, 1989 to one, the curative effect contrast observing that carries out with other medicine of clothes, subjective symptoms changes before and after the selected patient treatment, electrocardiogram changes, the electrocardial vector spectrogram, the heart B ultrasonic, cardiac function, situation of change such as blood viscosity and blood fat shows, the medicine of producing by prescription provided by the present invention and method not only has good short term effect, and very ideal late result is arranged, and is evident in efficacy.This shows that prescription provided by the invention and production method meet theory of Chinese medical science, and having well has social benefit.
Claims (2)
1, a kind of SHANHAI PILL for the treatment of arrhythmia type coronary heart disease is made up of multiple flavour of a drug, it is characterized in that: each pass of measuring between the medicine of distinguishing the flavor of is:
Radix Astragali 2000-3000g Radix Ginseng 300-500g
Radix Notoginseng 500-800g Fructus Crataegi 2000-3000g
Flos Carthami 300-450g Fructus Citri Sarcodactylis 300-450g
Radix Paeoniae Rubra 400-650g Rhizoma Cyperi (processed) 500-650g
Ganoderma 400-550g 400-450g Radix Ophiopogonis
Semen Cassiae 400-450g berberine 300-550g
Radix Salviae Miltiorrhizae 500-650g Ramulus Buxi Sinicae 400-850g
Radix Angelicae Pubescentis 400-650g Radix Sophorae Flavescentis 400-650g
Radix Trichosanthis 500-550g Fructus Schisandrae Chinensis 300-450g
Radix Glycyrrhizae Preparata 600-850g Folium Epimedii 300-450g
Radix Puerariae 600-850g Pollen Typhae 300-450g
Radix Polygoni Multiflori 300-450g
2, a kind of preparation technology of SHANHAI PILL of treatment arrhythmia type coronary heart disease according to claim 1, it is characterized in that: (1) is with the Radix Astragali, Radix Notoginseng, Radix Ginseng, Fructus Crataegi, Flos Carthami, Radix Angelicae Pubescentis, Radix Polygoni Multiflori, Fructus Citri Sarcodactylis, Radix Ophiopogonis, Ramulus Buxi Sinicae, Radix Sophorae Flavescentis, Fructus Schisandrae Chinensis, Folium Epimedii, Pollen Typhae, Radix Paeoniae Rubra, Radix Trichosanthis, Ganoderma, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae Preparata, Radix Puerariae, Rhizoma Cyperi (processed), adding water decocted 3 hours in a container, decoct the postpone that cools, got medicinal residues 1 and medicinal liquid 1 after filtration; (2) medicinal residues 1 and water were decocted two hours in same container, cool postpone filter medicinal residues 2 and medicinal liquid 2; (3) medicinal residues 2 and water are decocted in a container, have decocted the postpone that cools, cool postpone filter medicinal residues 3 and medicinal liquid 3; (4) merge medicinal liquid 1,2,3; (5) medicinal liquid is condensed into the thick paste shape; (6) in medicinal liquid, add 95% ethanol, make it to contain the alcohol amount and reach 60% and precipitate 24 hours; (7) recovered alcohol; (8) the berberine fine powder is added mixing in the concentrated medicament; (9) granulate; (10) the graininess medicine is dried; (11) the medicine grain is sieved after, the capsule of packing into No. 0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93101423A CN1085082C (en) | 1993-02-17 | 1993-02-17 | Recipe of Fumailing for curing arrhythmic coronary heart disease and producing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93101423A CN1085082C (en) | 1993-02-17 | 1993-02-17 | Recipe of Fumailing for curing arrhythmic coronary heart disease and producing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1097603A CN1097603A (en) | 1995-01-25 |
| CN1085082C true CN1085082C (en) | 2002-05-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93101423A Expired - Lifetime CN1085082C (en) | 1993-02-17 | 1993-02-17 | Recipe of Fumailing for curing arrhythmic coronary heart disease and producing method |
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| CN (1) | CN1085082C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084986B (en) * | 2006-06-08 | 2011-10-05 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing notoginseng and kudzuvine root and its preparation |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1055633C (en) * | 1997-10-22 | 2000-08-23 | 李建民 | Emplastrum for preventing and treating coronary heart disease |
| CN1084201C (en) * | 1999-04-26 | 2002-05-08 | 刘祖文 | Health-care saffron-notoginseng-pollen food and its preparing process |
| CN1115159C (en) * | 2000-08-22 | 2003-07-23 | 云南医药工业股份有限公司 | Red sage containing medicine composition and its preparation and use |
| CN100386112C (en) * | 2005-09-16 | 2008-05-07 | 高松寿 | Arrhythmia treating Chinese medicine prepn and its prepn process |
| CN101637563B (en) * | 2008-08-01 | 2012-12-26 | 上海慈济药业有限公司 | Chinese medicinal composition for treating viral myocarditis and preparation process thereof |
| CN102631538B (en) * | 2012-04-20 | 2014-01-15 | 蔡惠磊 | Traditional Chinese medicine for treating heart disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1030183A (en) * | 1987-06-30 | 1989-01-11 | 马德林 | A kind of manufacture method of preventing and treating the coronary heart disease medicine for external use |
| CN1052429A (en) * | 1990-09-15 | 1991-06-26 | 刘绍文 | The prescription of QIANGXIN JIANNAO YE, making |
-
1993
- 1993-02-17 CN CN93101423A patent/CN1085082C/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1030183A (en) * | 1987-06-30 | 1989-01-11 | 马德林 | A kind of manufacture method of preventing and treating the coronary heart disease medicine for external use |
| CN1052429A (en) * | 1990-09-15 | 1991-06-26 | 刘绍文 | The prescription of QIANGXIN JIANNAO YE, making |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084986B (en) * | 2006-06-08 | 2011-10-05 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing notoginseng and kudzuvine root and its preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1097603A (en) | 1995-01-25 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C53 | Correction of patent for invention or patent application | ||
| CB02 | Change of applicant information |
Applicant after: Zhao Guoxin Applicant after: Tao Ying Applicant before: Xi'an Traditional Chinese Medicine Multi-subject Inst., No.2 Artillery, PLA |
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| CB03 | Change of inventor or designer information |
Inventor after: Zhao Guoxin Inventor after: Tao Ying Inventor before: Zhao Guoxin |
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| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHAO GUOXIN TO: ZHAO GUOXIN; YAO YING; APPLICANT; FROM: SECOND ARTILLERY, XI AN INSTITUTE OF TRADITIONAL CHINESE MEDICINE MULTIDISCIPLINARY TO: ZHAO GUOXIN; YAO YING |
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| C53 | Correction of patent for invention or patent application | ||
| CB02 | Change of applicant information |
Applicant after: Xi'an Tranditional Chinese Medicine Multi-discripline Institute, Sanhaidan Enter Applicant before: Xi-an Traditional Chinese Medicine Multi-discipline Inst., Secondary Artillery P |
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| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: XI-AN TRADITIONAL CHINESE MEDICINE MULTI-DISCIPLINE INST., SECONDARY ARTILLERY P TO: SHANHAIDAN ENTERPRISES GROUP, XI AN INSTITUTE OF MULTIDISCIPLINARY HERBALIST DOCTOR |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20090311 Pledge (preservation): Preservation |
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| PD01 | Discharge of preservation of patent |
Date of cancellation: 20090911 Pledge (preservation): Preservation registration |
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| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20130217 Granted publication date: 20020522 |