CN1042495C - Medicine for benefitting Qi, removing cancer and raising leucocyte and its prepn. - Google Patents
Medicine for benefitting Qi, removing cancer and raising leucocyte and its prepn. Download PDFInfo
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- CN1042495C CN1042495C CN96100805A CN96100805A CN1042495C CN 1042495 C CN1042495 C CN 1042495C CN 96100805 A CN96100805 A CN 96100805A CN 96100805 A CN96100805 A CN 96100805A CN 1042495 C CN1042495 C CN 1042495C
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Abstract
The present invention discloses a Chinese patent medicine having the combined functions of preventing cancer, increasing body specificity and non-specific immunity properties, protecting marrow hematopoiesis functions, raising white cell numbers, preventing mutation and tumorigenesis, improving ordinary situations, eliminating poison and side reactions, increasing the treating effects of radiotherapy and chemotherapy and reducing the toxicity of the radiotherapy and the chemotherapy. The medicine is prepared from ingredients, such as angelica, ginseng, largehead atractylodes rhizome, tuckahoe, rehmannia root, white peony alba, nutgrass galingale rhizome, hemlock parsley, figwort root, rhubarb and safflower.
Description
The present invention relates to a kind of Chinese medicine composition; particularly have anticancer, improve body specificity and non-specific immunity; the protection hemopoietic function of bone marrow; leukocyte increasing quantity; the anti-mutation prophylaxis of tumours takes place; improve general situation and eliminate toxicity, improve the curative effect of radiation and chemotherapy and reduce the oral liquid and preparation method thereof of the benefitting Qi, removing cancer leukocyte increasing of effects such as its toxicity.
Tumor patient has more in existing deficiency of qi and blood, the stasis of blood poison in radiotherapy, chemotherapy and operation and accumulates.According to the clinical pharmacology Study on Theory, the curative effect of present most of chemotherapeutics is relevant with dosage, promptly within the specific limits, the dosage of chemotherapy and radiation is big more, its curative effect is high more, but owing to lack the metabolism difference of essence between tumor cell and the normal cell, therefore, all chemotherapy, radiotherapy all can not be avoided normal structure is produced infringement, especially hemopoietic system is vulnerable to infringement most, the bone marrow depression phenomenon often appears, leukopenia, the body constitution situation is low, and makes radiotherapy, chemotherapy can not be proceeded, and causes tumor to can not get control, cause the treatment failure, seriously influencing the life quality and the cure rate of tumour patient, how to guarantee the smooth treatment to tumour patient, is the important topic of present medical personnel's research.
To the leukopenia that causes because of radiotherapy, chemotherapy, the past adopts Western medicine adenine phosphate, leucogen etc., and its curative effect is very unobvious, as it is better to rise its curative effect of import medicine such as Bai Neng, but costs an arm and a leg, and patient bears the real difficulty that is.Therefore, some treatment by Chinese herbs medicines have appearred at present in this respect, for example, CN1087276 discloses a kind of chemotherapy of tumors Chinese medicine synergist and preparation method thereof, and this medicine components has Radix Ginseng, the Radix Astragali, Fructus Schisandrae Chinensis, Fructus Lycii, Radix Polygoni Multiflori, Lentinus Edodes, Rhizoma Chuanxiong, Poria, Radix Glycyrrhizae, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Et Caulis Acanthopanacis Senticosi, broker wall bee pollen.And for example, CN1090191 discloses and has been used to improve human leukocytes, hematoblastic Chinese patent medicine and preparation method thereof, and this medicine components is made up of Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis, Radix Codonopsis, Radix Scrophulariae, can be used as the adjuvant therapy medicaments of radiotherapy, chemotherapy.But the ideal medicament that can give rational therapy at present clinically to the leukopenia that radiotherapy, chemotherapy cause still is few in number; have anticancer, improve body specificity and non-specific immunity; the protection hemopoietic function of bone marrow; leukocyte increasing quantity; the anti-mutation prophylaxis of tumours takes place; improve general situation and eliminate toxicity, the Chinese patent medicine that improves the curative effect of radiation and chemotherapy and reduce comprehensive functions such as its toxicity is difficult to seek especially.
The object of the invention provide a kind of have anticancer, improve body specificity and non-specific immunity; the protection hemopoietic function of bone marrow; leukocyte increasing quantity; the anti-mutation prophylaxis of tumours takes place; improve general situation and eliminate toxicity, improve the curative effect of radiation and chemotherapy and reduce the Chinese patent medicine of comprehensive functions such as its toxicity.
The present invention also aims to provide a kind of method for preparing above-mentioned Chinese medicine liquor.
The inventor adopts the Therapeutic Principle of benefiting vital QI and blood, dissolving blood stasis and detoxication according to theory of Chinese medical science, in conjunction with the modern Chinese medicine achievement in research, in secular clinical observation practice, has summed up effective effect side.As prescription, prepare medicine of the present invention.
Pharmaceutical composition of the present invention is composed as follows by weight ratio:
Radix Angelicae Sinensis 60-100 part Radix Ginseng 60-100 part Rhizoma Atractylodis Macrocephalae 60-100 part
Poria 60-100 part Radix Rehmanniae 60-100 part Radix Paeoniae Alba 60-100 part
Rhizoma Cyperi 60-100 part Rhizoma Chuanxiong 60-100 part Radix Scrophulariae 60-100 part
Radix Et Rhizoma Rhei 60-100 part Flos Carthami 100-180 part
The preferred weight proportioning of pharmaceutical composition each component of the present invention is:
Radix Angelicae Sinensis 80-90 part Radix Ginseng 80-90 part Rhizoma Atractylodis Macrocephalae 80-90 part
Poria 80-90 part Radix Rehmanniae 80-90 part Radix Paeoniae Alba 80-90 part
Rhizoma Cyperi 80-90 part Rhizoma Chuanxiong 80-90 part Radix Scrophulariae 80-90 part
Radix Et Rhizoma Rhei 80-90 part Flos Carthami 140-160 part
The optimum weight proportioning of pharmaceutical composition each component of the present invention is:
85 parts of 85 parts of Rhizoma Atractylodis Macrocephalaes of 85 parts of Radix Ginsengs of Radix Angelicae Sinensis
85 parts of 85 portions of Radix Paeoniae Albas of 85 parts of Radix Rehmanniae of Poria
85 parts of 85 portions of Radix Scrophulariaes of 85 parts of Rhizoma Chuanxiongs of Rhizoma Cyperi
150 parts on 85 parts of Flos Carthamis of Radix Et Rhizoma Rhei
Pharmaceutical composition of the present invention can be prepared into any pharmaceutical dosage form that is suitable for clinically according to the preparation process of routine, comprises dosage forms such as oral liquid, tablet, pill, capsule, injection, powder, infusion solution, Emulsion, suspension, syrup, soft extract.
Medicine processing method of the present invention is:
Radix Angelicae Sinensis in the aforementioned pharmaceutical compositions component, Rhizoma Chuanxiong, Rhizoma Cyperi and the Rhizoma Atractylodis Macrocephalae are added 5-7 times of water gaging, flooded 20-30 hour, distillation extraction gets distillate, collects the slide liquid that quite above-mentioned four flavor crude drug weight 2-3 doubly measure, and device is preserved in addition.Medicinal residues, residual liquid are with seven flavor medicines such as all the other Radix Paeoniae Albas, decoct with water three times, filter, merging filtrate, the 1-2 that is concentrated into all the other seven flavor medicine weight doubly measures, add ethanol then, make to contain amount of alcohol and reach 75%, standing over night is filtered, reclaim ethanol, the 1/4-1/2 that is concentrated into suitable prescription raw material gross weight is doubly measured.Merge with distillate, adjust milliliter number that volume makes its final quantity equal the to write out a prescription gram number of raw material gross weight, stand at low temperature 3 days filters, potting, sterilization.
That medicine of the present invention has is anticancer, improve body specificity and non-specific immunity; the protection hemopoietic function of bone marrow, leukocyte increasing quantity, the anti-mutation prophylaxis of tumours takes place; improve general situation and eliminate toxicity, improve the curative effect of radiation and chemotherapy and reduce comprehensive function such as its toxicity.
Medicine oral liquid of the present invention (the clinical application title: clinical research result eight delicacies legendary god of farming drink) is reported as follows:
One, data and method
1, medicine: eight delicacies legendary god of farming drink is provided 100 milliliters every bottle by the legendary god of farming of Zhengzhou City institute of oncology.The FUFANG EJIAO JIANG oral liquid is produced by Acheng, Shandong pharmaceutical factory, and 10 milliliters every, ten dresses of every box.
2, patient's situation: this group is observed 180 routine patients altogether, and wherein 120 examples are organized in treatment, matched group 60 examples.Be through radiotherapy or chemotherapy and the leukopenia patient who causes, the malignant tumor patient that all patients all make a definite diagnosis through cytology and/or pathology comprises esophageal carcinoma, carcinoma of gastric cardia, gastric cancer, laryngeal carcinoma, nasopharyngeal carcinoma, carcinoma of tongue, carcinoma of tonsil, pulmonary carcinoma, breast carcinoma, malignant lymphoma, cancer of pancreas, hepatocarcinoma, colon cancer etc.
Treatment group: mean and adopt the eight delicacies legendary god of farming to drink the patient of treatment, male's 85 examples, women's 35 examples, the range of age 12-75 year, The median age 52 years old.
Matched group: mean the patient who uses the FUFANG EJIAO JIANG oral liquid treatment, male's 37 examples, women's 23 examples.The range of age 12-72 year, The median age 47.5 years old.
3, the administrated method and the course of treatment
The treatment group: the eight delicacies legendary god of farming drinks each 50 milliliters, and every day 3 times is oral.
Matched group: each 20 milliliters of FUFANG EJIAO JIANG, every day 3 times is oral.
The course of treatment: two groups are 14 days.Two groups of patients are application before taking medicine other rise the blood picture medicine.
4, criterion of therapeutical effect
Produce effects: the 7 days total white blood cellses of taking medicine recover normal, promptly 〉=4.0 * 10
9/ L, cardinal symptom is alleviated (+) above person.
Effectively: taking medicine, total white blood cells recovers normal in 14 days, promptly 〉=4.0 * 10
9/ L, cardinal symptom is alleviated (+) above person.
To treating proleukocyte 3.5 * 10
9The above person of/L, treatment back leukocyte must raise 0.5 * 10
9The above person of/L can be judged to be effectively or produce effects, otherwise be invalid.
Invalid: the total white blood cells of taking medicine in 14 days fails to return to normal person, or numeration of leukocyte raises＜0.5 * 10
9/ L person, it is invalid all to be considered as.
Two, 120 67 (55.83) 43 (35.83) 10 (8.33) 110 (91.67) matched groups, 60 14 (23.33) 19 (31.67) 27 (45.00) 33 (55.00) statistical procedures are organized in effective (%) invalid (%) total effective rate (%) treatment of therapeutic outcome group example digital display effect (%): two groups of significant difference (X
2=35.1610P＜0.01).
Clinical cardinal symptom improve situation as: fatigue and weakness, dizziness, breathe hard, poor appetite, symptom such as feel sick.Treatment group treatment precedent number is respectively: 87,54,58,78,35; The routine number in treatment back is respectively: 19,9,3,15,5.
The result shows that accumulateing symptom in deficiency of qi and blood that eight delicacies legendary god of farming drink causes radiotherapy, chemotherapy, the stasis of blood poison improves significantly.
The toxic and side effects of medicine: electrocardiogram, liver function, routine urianlysis show that the eight delicacies legendary god of farming drinks the no obvious heart, liver, renal function injury before and after the treatment.
The clinical research of this group is the result show, the eight delicacies legendary god of farming drinks the treatment leukopenia, and obvious effective rate is 55.83%, and effective percentage is 35.83%, and inefficiency is 8.33%.Than matched group.It is excellent to be that the FUFANG EJIAO JIANG group is evident as, and the latter's obvious effective rate, effective percentage and inefficiency are respectively: 23.33%, 35.67%, 45%.
Embodiment 1
Prescription:
The Radix Angelicae Sinensis 85 gram Radix Ginsengs 85 gram Rhizoma Atractylodis Macrocephalaes 85 grams
The Poria 85 gram Radix Rehmanniae 85 gram Radix Paeoniae Albas 85 grams
Rhizoma Cyperi 85 gram Rhizoma Chuanxiongs 85 gram Radix Scrophulariaes 85 grams
Radix Et Rhizoma Rhei 85 gram Flos Carthamis 150 grams
Method for making:
Radix Angelicae Sinensis in the aforementioned pharmaceutical compositions component, Rhizoma Chuanxiong, Rhizoma Cyperi and the Rhizoma Atractylodis Macrocephalae are added 2000 milliliters in water, flooded 24 hours, distillation extraction gets distillate, collects 700 milliliters of slide liquid, and device is preserved in addition.Medicinal residues, residual liquid decoct with water three times with seven flavor medicines such as all the other Radix Paeoniae Albas, and three times amount of water is respectively 2000 milliliters, 1000 milliliters, 1000 milliliters, decocting time was respectively 1 hour, 0.5 hour, 0.5 hour, filter, merging filtrate is concentrated into 1000 milliliters, add ethanol then, make to contain amount of alcohol and reach 75%, left standstill 24 hours, filter, reclaim ethanol, make to be concentrated into 300 milliliters.Merge with distillate, adjust volume to 1000 milliliter, stand at low temperature 3 days filters, potting, sterilization.
Embodiment 2
Prescription:
The Radix Angelicae Sinensis 170 gram Radix Ginsengs 170 gram Rhizoma Atractylodis Macrocephalaes 170 grams
The Poria 170 gram Radix Rehmanniae 170 gram Radix Paeoniae Albas 170 grams
Rhizoma Cyperi 170 gram Rhizoma Chuanxiongs 170 gram Radix Scrophulariaes 170 grams
Radix Et Rhizoma Rhei 170 gram Flos Carthamis 300 grams
Method for making:
Radix Angelicae Sinensis in the aforementioned pharmaceutical compositions component, Rhizoma Chuanxiong, Rhizoma Cyperi and the Rhizoma Atractylodis Macrocephalae are added 4000 milliliters in water, flooded 24 hours, distillation extraction gets distillate, collects 1400 milliliters of slide liquid, and device is preserved in addition.Medicinal residues, residual liquid decoct with water three times with seven flavor medicines such as all the other Radix Paeoniae Albas, filter, and merging filtrate is concentrated into 2000 milliliters, adds 90% ethanol then, make to contain amount of alcohol and reach 75%, leave standstill 24 hours, filter, and reclaim ethanol, make to be concentrated into 600 milliliters.Merge with distillate, adjust volume to 2000 milliliter, stand at low temperature 3 days filters, potting, sterilization.
The application's accompanying drawing is the technological process of production figure of oral liquid of the present invention.
Claims (6)
1, a kind of medicine for benefitting Qi, removing cancer and raising leucocyte is characterized in that it is the medicament of being made by the component of following weight proportioning:
Radix Angelicae Sinensis 60-100 part Radix Ginseng 60-100 part Rhizoma Atractylodis Macrocephalae 60-100 part
Poria 60-100 part Radix Rehmanniae 60-100 part Radix Paeoniae Alba 60-100 part
Rhizoma Cyperi 60-100 part Rhizoma Chuanxiong 60-100 part Radix Scrophulariae 60-100 part
Radix Et Rhizoma Rhei 60-100 part Flos Carthami 100-180 part
2,, it is characterized in that it is the medicament of being made by the component of following weight proportioning according to the medicine of claim 1:
Radix Angelicae Sinensis 80-90 part Radix Ginseng 80-90 part Rhizoma Atractylodis Macrocephalae 80-90 part
Poria 80-90 part Radix Rehmanniae 80-90 part Radix Paeoniae Alba 80-90 part
Rhizoma Cyperi 80-90 part Rhizoma Chuanxiong 80-90 part Radix Scrophulariae 80-90 part
Radix Et Rhizoma Rhei 80-90 part Flos Carthami 140-160 part
3,, it is characterized in that it is the medicament of being made by the component of following weight proportioning according to the medicine of claim 1:
85 parts of 85 parts of Rhizoma Atractylodis Macrocephalaes of 85 parts of Radix Ginsengs of Radix Angelicae Sinensis
85 parts of 85 portions of Radix Paeoniae Albas of 85 parts of Radix Rehmanniae of Poria
85 parts of 85 portions of Radix Scrophulariaes of 85 parts of Rhizoma Chuanxiongs of Rhizoma Cyperi
150 parts on 85 parts of Flos Carthamis of Radix Et Rhizoma Rhei
4, according to the medicine of claim 1 or 2 or 3, wherein said pharmaceutical formulation is an oral liquid.
5, a kind of oral liquor of benefitting Qi, removing cancer leukocyte increasing is characterized in that this method comprises:
A, choose raw medicinal material by following prescription
Radix Angelicae Sinensis 60-100 weight portion Radix Ginseng 60-100 weight portion Rhizoma Atractylodis Macrocephalae 60-100 weight portion
Poria 60-100 weight portion Radix Rehmanniae 60-100 weight portion Radix Paeoniae Alba 60-100 weight portion
Rhizoma Cyperi 60-100 weight portion Rhizoma Chuanxiong 60-100 weight portion Radix Scrophulariae 60-100 weight portion
Radix Et Rhizoma Rhei 60-100 weight portion Flos Carthami 100-180 weight portion
B, Radix Angelicae Sinensis with above-mentioned component, Rhizoma Chuanxiong, the Rhizoma Cyperi and the Rhizoma Atractylodis Macrocephalae add 5-7 times of water gaging, flooded 20-30 hour, distillation extraction gets distillate, collects the slide liquid that quite above-mentioned four flavor crude drug weight 2-3 doubly measure, device is preserved in addition, medicinal residues, residual liquid decocts with water three times with seven flavor medicines such as all the other Radix Paeoniae Albas, filters, merging filtrate, the 1-2 that is concentrated into all the other seven flavor medicine weight doubly measures, and adds ethanol then, makes amount of alcohol reach 75%, standing over night, filter, reclaim ethanol, the 1/4-1/2 that is concentrated into suitable prescription raw material gross weight is doubly measured, merge with distillate, adjust milliliter number that volume makes its final quantity equal the to write out a prescription gram number of raw material gross weight, stand at low temperature 3 days filters, potting, sterilization.
6,, it is characterized in that this method comprises according to the preparation method of claim 5:
A, choose raw medicinal material by following prescription
The Radix Angelicae Sinensis 85 gram Radix Ginsengs 85 gram Rhizoma Atractylodis Macrocephalaes 85 grams
The Poria 85 gram Radix Rehmanniae 85 gram Radix Paeoniae Albas 85 grams
Rhizoma Cyperi 85 gram Rhizoma Chuanxiongs 85 gram Radix Scrophulariaes 85 grams
Radix Et Rhizoma Rhei 85 gram Flos Carthamis 150 grams
B, the Radix Angelicae Sinensis with in the above-mentioned component, Rhizoma Chuanxiong, Rhizoma Cyperi and the Rhizoma Atractylodis Macrocephalae add 2000 milliliters in water, flood distillation extraction 24 hours, get distillate, collect 700 milliliters of slide liquid, device is preserved in addition, medicinal residues, residual liquid decoct with water three times with seven flavor medicines such as all the other Radix Paeoniae Albas, filter, merging filtrate, be concentrated into 1000 milliliters, add ethanol then, make to contain amount of alcohol and reach 75%, left standstill 24 hours, filter, reclaim ethanol, make to be concentrated into 300 milliliters, merge with distillate, adjust volume to 1000 milliliter, stand at low temperature 3 days filters, potting, sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96100805A CN1042495C (en) | 1996-01-22 | 1996-01-22 | Medicine for benefitting Qi, removing cancer and raising leucocyte and its prepn. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96100805A CN1042495C (en) | 1996-01-22 | 1996-01-22 | Medicine for benefitting Qi, removing cancer and raising leucocyte and its prepn. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1138476A CN1138476A (en) | 1996-12-25 |
| CN1042495C true CN1042495C (en) | 1999-03-17 |
Family
ID=5116754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96100805A Expired - Fee Related CN1042495C (en) | 1996-01-22 | 1996-01-22 | Medicine for benefitting Qi, removing cancer and raising leucocyte and its prepn. |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1042495C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100366276C (en) * | 2006-03-22 | 2008-02-06 | 郭占山 | Medicine for mediating blood cell to raise immunity |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100401955B1 (en) * | 2000-05-03 | 2003-10-17 | 한국원자력연구소 | The pharmaceutical composition and its preparation method of herb mixture for immunomodulation, heamatopoiesis augmentation and protection from radiation |
-
1996
- 1996-01-22 CN CN96100805A patent/CN1042495C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《上海中医药杂志》1992年第12期 1992.12.1 "牛忆‘生血灵汤’治疗化疗后白细胞，血小板减少72例" * |
| 《吉林中医药》1991年第6期 1991.6.1 张心海，"升白汤治疗原发性白细胞减少36例";《上海中医药杂志》1992年第12期 1992.12.1 "牛忆‘生血灵汤’治疗化疗后白细胞，血小板减少72例" * |
| 《吉林中医药》1991年第6期 1991.6.1 张心海，"升白汤治疗原发性白细胞减少36例" * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100366276C (en) * | 2006-03-22 | 2008-02-06 | 郭占山 | Medicine for mediating blood cell to raise immunity |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1138476A (en) | 1996-12-25 |
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