CN1233389C - Chinese materia medica preparation made from gen-seng and astragalus root for strengthening the body resistance and anti cancer as well as producing method - Google Patents
Chinese materia medica preparation made from gen-seng and astragalus root for strengthening the body resistance and anti cancer as well as producing method Download PDFInfo
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Abstract
The present invention discloses an anticancer Chinese drug preparation made from ginseng and astragalus root for strengthening body resistance and a preparation method thereof. The Chinese drug preparation is prepared from 3 to 20 wt% of ginseng, 5 to 30 wt% of astragalus root, 5 to 30 wt% of oldenlandia, 5 to 30 wt% of barbat skullcap, 1 to 15 wt% of edible tulip, 3 to 20 wt% of zedoary, 1 to 15 wt% of radices pseudoginseng, 1 to 15 wt% of safflower, 5 to 30 wt% of coix seed, 3 to 20 wt% of tuckahoe, 3 to 20 wt% of acanthopanax senticosus, 1 to 15 wt% of bighead atractylodes rhizome, 1 to 15 wt% of glossy privet fruit and 3 to 20 wt% of wolferry fruit which can be used for preparing a tablet, a capsule, a granule preparation, a powdered preparation, a pill, oral liquid, syrup and other clinic acceptable preparations. The Chinese drug preparation has the function of obviously improving deficiency of both qi and blood and blood stasis, and can reinforce the human body immune function, and the tumor increase is inhibited. The effective treating rate can reach 79.16%, and the patient's life quality is effectively improved. The Chinese drug preparation can used for the auxiliary treatment of leukemia, and has the functions of increasing human bodies'red cells, haemoglobin and platelets and nourishing blood.
Description
Technical field
The present invention relates to a kind of can the auxiliary for treating cancer disease, strengthen human immunologic function's Chinese medicine medicine for preventing preparation and preparation method.
Background technology
The cancer patient often has QI and blood deficiency, blood stasis disease, and its cause of disease because evil poison is taken advantage of a weak point, causes and accumulates, causes in the wet poly-and pyretic toxicity of expectorant knot evilly to contain weakened body resistance, deficiency of both QI and blood and carcinogenic generation often.Its conventional treatments has Therapeutic Method such as operation, chemotherapy, radiotherapy, because that cancer is found and made a definite diagnosis is later, what have loses the operation good opportunity, and the toxic and side effects of chemotherapy and radiation is more common and multiple complications takes place, and brings many miseries to patient.Cancer needs of patients medicine comes the human body immunity improving function, remove carcinous detoxifying function, directly press down cancer, control cancer cell infiltration and transfer, alleviate the side reaction of perioperatively, radiotherapy or chemotherapy, improve the quality of life of cancer patient, though can not effect a radical cure, also can reach and prolong life cycle, the purpose that the band cancer is prolonged life.Existing its therapeutic effect of prescription is not good enough, curative effect is not obvious, and effective percentage is low.
Summary of the invention
The invention provides a kind of anticancer SHENQI FUZHENG Chinese medicine preparation and preparation method, this Chinese medicine preparation has certain inhibitory action to kinds of tumors, simultaneously body's immunological function there is certain potentiation, can effectively improve the quality of life of cancer patient, alleviate the disease misery of cancer patient, blood circulation promoting and blood stasis dispelling is arranged, benefiting qi and nourishing blood, the effect of the anticancer intrinsic resistance of enhancing body, utilize heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the dampness removing etc. that reduces phlegm is eliminating evil does not hinder positive Therapeutic Method, outstanding setting upright, blood stasis dispelling, eliminating evil comprehensive function function, good anticancer function is arranged, can also the auxiliary treatment leukemia.
The invention provides such technical scheme: a kind of anticancer SHENQI FUZHENG Chinese medicine preparation, formulated by following raw materials according percentage ratio by weight: Radix Ginseng 3-20%, Radix Astragali 5-30%, Herba Hedyotidis Diffusae 5-30%, Herba Scutellariae Barbatae 5-30%, Pseudobulbus Cremastrae Seu Pleiones 1-15%, Rhizoma Curcumae 3-20%, Radix Notoginseng 1-15%, Flos Carthami 1-15%, Semen Coicis 5-30%, Poria 3-20%, Radix Et Caulis Acanthopanacis Senticosi 3-20%, Rhizoma Atractylodis Macrocephalae 1-15%, Fructus Ligustri Lucidi 1-15% and Fructus Lycii 3-20%.
Described raw material is by formulated by the percentage ratio of following weight: Radix Ginseng 6.6%, the Radix Astragali 13.1%, Herba Hedyotidis Diffusae 9.8%, Herba Scutellariae Barbatae 9.8%, Pseudobulbus Cremastrae Seu Pleiones 4.9%, Rhizoma Curcumae 6.6%, Radix Notoginseng 4.9%, Flos Carthami 4.9%, Semen Coicis 9.8%, Poria 6.6%, Radix Et Caulis Acanthopanacis Senticosi 6.6%, the Rhizoma Atractylodis Macrocephalae 4.9%, Fructus Ligustri Lucidi 4.9% and Fructus Lycii 6.6%.
Described anticancer SHENQI FUZHENG Chinese medicine preparation is tablet, capsule, granule, powder, pill, oral liquid or syrup.
Described tablet, undertaken by following process: (1) is got the Radix Astragali, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Coicis, Poria, Radix Et Caulis Acanthopanacis Senticosi and Fructus Ligustri Lucidi powder and is broken into thick piece, add above 5-15 times of water gaging of each component gross weight, heating decocts 1-3 time, each 1-4 hour, gradation filtered, merging filtrate, be concentrated into the thick paste shape, the relative density of temperature in the time of 50 ℃ is 1.0-1.5; (2) get Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Rhizoma Curcumae, Flos Carthami, Radix Notoginseng and Pseudobulbus Cremastrae Seu Pleiones and be ground into 60-120 purpose fine powder, sieve; (3) ointment that (1) method is made mixes with the medicated powder that (2) method makes, and 50-80 ℃ of drying pulverized, and sieves, and add starch or dextrin and other adjuvant and make granule, drying, granulate adds the compacting of magnesium stearate or other adjuvant in flakes.
Described capsule, undertaken by following process: get the ointment that (1) method makes in the above-mentioned method for preparing tablet thereof and mix with the medicated powder that (2) method makes, 50-80 ℃ of drying pulverized, and sieves, and incapsulates to get final product.
Described granule, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, and 50-80 ℃ of drying pulverized, and sieves, and adds starch or dextrin and other adjuvant and makes granule.
Described powder, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, 50-80 ℃ of drying, pulverizing gets final product.
Described pill, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, 50-80 ℃ of drying, be ground into powder, the Mel of the grain weight of getting it filled amount 0-130% boils, filter, it is that the 0-15% ethanol of 40-60% is made pill that medicated powder is added 0-130% Mel and 0-15% water, concentration.
Described oral liquid, undertaken by following process: (1) is got the Radix Astragali, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Coicis, Poria, Radix Et Caulis Acanthopanacis Senticosi, Fructus Ligustri Lucidi, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Rhizoma Curcumae, Flos Carthami, Radix Notoginseng and Pseudobulbus Cremastrae Seu Pleiones and is ground into thick piece, add above 5-15 times of water gaging of each component gross weight, heating decocts 1-3 time, each 1-4 hour, gradation filters, and merging filtrate concentrates; (2) concentrated medicament that (1) method is made adds the antiseptic of medicinal liquid gross weight 0.1-1%, the correctives mix homogeneously of 0.1-2%, makes oral liquid.
Described syrup, undertaken by following process: (1) gets concentrated medicament by above-mentioned oral liquid preparation technology (1) legal system; (2) sucrose is dissolved in the distilled water that boils, making concentration is the simple syrup of 85% (g/ml) or 64.7% (g/g); (3) concentrated medicament is added in the simple syrup, add an amount of distilled water and make syrup.
This Chinese medicine preparation has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals, animal pharmacodynamics test and treatment disease, and the beneficial effect of this medicine input being treated the use link generation of disease provides science and objective foundation.Its test method and result of the test are as follows respectively:
1, anticancer SHENQI FUZHENG ball animal acute toxicity test:
Medicine: anticancer SHENQI FUZHENG ball is provided by the LiaoYuan YaDong Medicine Co., Ltd., Jilin Province.
Experimental animal: Kunming mouse, body weight 18-22g, portion provides by Norman Bethune Medical University's laboratory animal, the quality certification number: 0004776.
Method and result: 1) medicine preparation: it is standby that anticancer SHENQI FUZHENG ball is mixed with 40% suspension with distilled water, 2) after the mice fasting 16 hours (can't help water), morning next day, pressing the filling of 0.4ml/10g body weight with 40% anticancer SHENQI FUZHENG ball suspension feeds, observed 7 days the record reaction after the administration continuously.None example is dead as a result, test also tests out the administration of its mouse oral clothes the maximum tolerated dose of anticancer SHENQI FUZHENG ball is surpassed the 32g/kg body weight/day, be higher than clinical adult's whole day plan 66.6 times, do not see toxic reaction and animal dead after 7 days, show the oral safety of this medicine with dosage.
2, anticancer SHENQI FUZHENG ball long-term toxicity test for animals:
Medicine: anticancer SHENQI FUZHENG ball is provided by the LiaoYuan YaDong Medicine Co., Ltd., Jilin Province.
Experimental animal: 66 of the Wister rats about birth eight weeks of back, body weight 80-100g, male and female half and half, portion provides by the Norman Bethune Medical University animal.
Instrument: automatic clinical chemistry analyzer (HIT's 7070 types)
Automatic hemacytometer (Beijing Ai Erma company)
Method: rat is divided into three groups at random, every group 22, male and female half and half, the conventional raising week, situations such as activities in rats, feed, feces are all normal, three treated animals are pressed following dosage medicine feed: high dose group: 40% SHENQI FUZHENG ball 2ml/100g body weight, low dose group: 20% SHENQI FUZHENG ball 2ml/100g body weight, matched group: wait the dosage normal saline to irritate stomach.The behavior characteristics of each treated animal of observed and recorded, behavioral activity, the feces shape, dietary amount and body weight change (weighing in once weekly), etc. physical signs, in last administration 24 hours, get 14 animals for every group, after defending barbital sodium (40mg/kg lumbar injection) anesthesia, through the abdominal aortic cannulation sacrificed by exsanguination, get blood, be the hematology, blood biochemical is learned and histopathological examination, 6 animals of every group of remainder continue to raise, observing the back employing of two weeks puts to death with quadrat method, do the These parameters inspection, with the degree of reversibility of understanding the toxic reaction that this medicine may occur and have or not the retardance toxic reaction.Through to three treated animals in the continuous observation during this after two weeks of eight weeks of administration and drug withdrawal, anticancer SHENQI FUZHENG ball high dose group and low dose group activity freely, hair color gloss, clean appearance, the mouth and nose place does not have bad secretions, diet is urinated just normally, is physically well developed each treated animal body weight gain basically identical.Hematology's testing result shows, two weeks after eight weeks of successive administration and the drug withdrawal, every data such as packed cell volume, content of hemoglobin, platelet count, numeration of leukocyte and lymph of anticancer SHENQI FUZHENG ball high dose group and low dose group rat are all in the physical signs of rat within normal range, the equal no significant difference of the more every index of administration group and matched group, P＞0.05.Its hepatic and renal function is influence not, does not see after the drug withdrawal that the reversibility toxic reaction takes place.
3, SHENQI FUZHENG ball animal pharmacodynamics test
(1) to the inhibitory action of animal transplanting tumor
(a) anticancer SHENQI FUZHENG ball is to the influence of tumor-bearing mice (S180) tumor bulk-growth and body weight
Trial drug: anticancer SHENQI FUZHENG ball powder, provide by the LiaoYuan YaDong Medicine Co., Ltd., Jilin Province, be mixed with 20% and 10% suspension during use respectively; Cyclophosphamide is produced lot number: 940106 by Shanghai No.12 Pharmaceutical Factory.
Test material: rat liver cancer cell strain S
180, provide by Norman Bethune Medical University's Pathological Staff Room.
Experimental animal: 120 of kunming mices (in three batches, 40 every batch), body weight 18-22g, male and female half and half, the quality certification number: 9400019, portion provides by the Norman Bethune Medical University animal.
Test method:
Mice S
180The preparation of carcinoma cell strain: will be in liquid nitrogen frozen S
180The carcinoma cell strain is taken out, 37 ℃ of warm water recoveries, and centrifugal treating is abandoned cryopreserving liquid, adds normal saline again and washes twice, is inoculated in the kunming mice intraperitoneal, and aseptic condition extracted the tumor liquid in the abdominal cavity down after 7 days, with 1: 3 ratio physiological saline solution diluted for use.
Mice S
180The inoculation of carcinoma cell, get 40 of mices, under aseptic condition, extract previously prepared tumor liquid, every right oxter of mice is injected 0.2ml respectively, is divided into 4 groups after 24 hours at random, 10 every group, and weigh in, through gastric infusion, dosage is respectively once a day: the blank group: normal saline 0.5ml/10g body weight, positive controls: cyclophosphamide 20mg/kg, low dose group: anticancerly prolong living ball 5g/kg body weight, high dose group: anticancerly prolong living ball 10g/kg body weight, successive administration 7 days, mice is put to death in the back of weighing next day after the drug withdrawal, peel off the tumor piece, the tumor of weighing body weight is calculated suppression ratio, triplicate.See Table 1.
Table 1
| Group and dosage form | The example number | Tumor body weight (g) | Suppression ratio |
| Normal saline group cyclophosphamide group low dose group high dose group | 30 30 30 30 | 1.6500±0.1486 0.6450±0.1173** 1.2790±0.1607* 1.0800±0.1527* | 60.9 20.9 34.5 |
The result shows: anticancer two doses of groups of living ball and the cyclophosphamide group mice S of prolonging
180The tumor body weight is starkly lower than the normal saline matched group, P＜0.05,0.01.Except that positive controls (cyclophosphamide group), all the other each treated animal body weight all have slight decline.
(b) anticancerly prolong living ball to mice (H
22) influence of tumor bulk-growth and body weight
Trial drug: anticancer SHENQI FUZHENG ball powder, provide by the LiaoYuan YaDong Medicine Co., Ltd., Jilin Province, be mixed with 20% and 10% suspension during use respectively; Cyclophosphamide is produced lot number: 940106 by Shanghai No.12 Pharmaceutical Factory.
Experimental animal: 120 of kunming mices (in three batches, 40 every batch), body weight 18-22g, male and female half and half, the quality certification number: 9400019, portion provides by Norman Bethune Medical University's experimental animal.
Test method: get 40 of mices, be divided into 4 groups of matched group, cyclophosphamide-a control group, anticancer SHENQI FUZHENG ball high dose group and low dose group, 10 every group, preceding 24 hours of administration is after the weighing mice body weight, respectively at the right axil subcutaneous vaccination of mice mice (H
22), tumor liquid 0.2ml, gastric infusion is 7 days continuously, is respectively through dosage once a day: the blank group: normal saline 0.5ml/10g body weight, positive controls: cyclophosphamide 20mg/kg, low dose group: anticancer SHENQI FUZHENG ball 5g/kg body weight, high dose group: anticancer SHENQI FUZHENG ball 10g/kg body weight, mice is put to death in 24 hours backs of weighing in after the drug withdrawal, the tumor of weighing body weight is calculated mean, the group difference check is checked with t, calculates suppression ratio, triplicate.See Table 2.
Table 2
| Group and dosage form | Example number (N) | Tumor body weight (g) | Suppression ratio |
| Normal saline group low dose group high dose group cyclophosphamide group | 30 30 30 30 | 1.6967±0.1418 1.3593±0.1223* 1.1250±0.1826* 0.8147±0.1644** | 20.1 33.4 51.7 |
The result shows: two doses of groups of anticancer SHENQI FUZHENG ball also have the effect that suppresses growth to mice H22 tumor body weight.* P＜0.001 is expected in P＜0.05.Each treated animal body weight all has decline in various degree.
Above result of the test shows that anticancer SHENQI FUZHENG ball is to tumor-bearing mice S
180, tumor-bearing mice H
22The tumor bulk-growth obvious suppression effect is all arranged.
(2) anticancer SHENQI FUZHENG ball is to Immune Effects
(a) anticancer SHENQI FUZHENG ball is to the influence of mice reticuloendothelial system phagocytic function
Trial drug: anticancer SHENQI FUZHENG powder, provide by the LiaoYuan YaDong Medicine Co., Ltd., Jilin Province, be mixed with 20% and 10% suspension during use respectively; India ink, stock solution normal saline dilution in 1: 5; Heparin-saline; 0.1%NaCO
3751 spectrophotometers.
Experimental animal: 60 of kunming mices, body weight 18-22g, male and female half and half, the quality certification number: 9400021, portion provides by Norman Bethune Medical University's animal experiment.
Test method: 60 mices are divided into two groups greatly, 30 every group, one group of mouse inoculation mice S wherein at random
180Tumor, another group is not done inoculated tumour and is handled, be divided into blank group and anticancer SHENQI FUZHENG powder high dose group, low dose group more at random with each big group, mice feeds administration through irritating, dosage is respectively: matched group, normal saline 0.5ml/10g group, small dose group 5g/kg, high dose group 10g/kg body weight, every morning is irritated stomach once.Successive administration 7 days, 30min after the last administration, mice is through tail vein injection india ink 0.05ml/10g body weight, and 2min, 10min get blood 20ul with suction pipe from mice socket of the eye vein respectively at the injection back, are dissolved in 2ml0.1%NaCO
3Shake up in the solution, put 751 spectrophotometers colorimetric under wavelength 680nm, measure optical density (OD), calculate by following fraction and clean up index K.No tumor mice sees Table 3, and the inoculated tumour mice sees Table 4.
Table 3
| Group and dosage form | Example number (N) | Clean up index |
| Normal saline group low dose group high dose group | 10 10 10 | 0.0054±0.0017 0.0475±0.0399** 0.0819±0.0354** |
**P＜0.01
Table 4
| Group and dosage form | Example number (N) | Clean up index |
| Normal saline group low dose group high dose group | 10 10 10 | 0.065±0.0294 0.072±0.0028 0.086±0.0031 |
P＞0.05
The result shows: mice under the no warty attitude, anticancer SHENQI FUZHENG powder successive administration 7 days, two dosage group clearance in mice index K are all apparently higher than the normal saline matched group, relatively no significant difference of tumor clearance in mice index K and matched group is arranged, point out anticancer SHENQI FUZHENG powder that the nonspecific immunity function of normal mouse is had obvious facilitation.
In addition, also done the correlation test of animal, this Chinese medicine preparation has obvious facilitation to nonspecific immunity, cellular immunization and the humoral immune function of normal mouse, and immune function of mice under the inoculation neoplastic state is had certain promotion trend.
Show that by above result of the test this anticancer SHENQI FUZHENG Chinese medicine preparation can obviously improve normal mouse specific immunity and non-specific immunity, and multiple entity tumor is had certain inhibitory action, and the immunocompetence of energy enhancing body.
Beneficial effect of the present invention: the present invention observes through a large amount of clinical trials, 120 routine malignant tumor patients have been carried out clinical observation, obvious effective rate is 17.5% as a result, effective percentage is 61.66%, total effective rate is 79.16%, coupling chemotherapy or micro-wave therapeutic effective percentage 83.3%, has the obvious QI and blood deficiency of improving, the effect of blood stasis disease, has the inhibition tumor propagation, strengthen human immunologic function's function, can also obviously improve patient's picture of the tongue and pulse condition,, measure the quality of life that this Chinese medicine can obviously improve patient with the inquiring integration method with reference to multiple symptom standard, by observation to patient's hemogram, this medicine has certain blood tonification effect as can be seen, and to the clinical observation treatment of 31 routine leukemia examples, total effective rate reaches 80.6%, wherein single with group effective percentage 73.3%, unite low dose of chemotherapeutic treatment group effective percentage and reach 87.5%, better efficacy proves that this anticarcinogen to Leukemia Patients has certain auxiliary treatment effect.
The specific embodiment
A kind of anticancer SHENQI FUZHENG Chinese medicine preparation is tablet, capsule, granule, powder, pill, oral liquid or syrup.
Prepare by weight percentage by following raw materials according: Radix Ginseng 3-20%, Radix Astragali 5-30%, Herba Hedyotidis Diffusae 5-30%, Herba Scutellariae Barbatae 5-30%, Pseudobulbus Cremastrae Seu Pleiones 1-15%, Rhizoma Curcumae 3-20%, Radix Notoginseng 1-15%, Flos Carthami 1-15%, Semen Coicis 5-30%, Poria 3-20%, Radix Et Caulis Acanthopanacis Senticosi 3-20%, Rhizoma Atractylodis Macrocephalae 1-15%, Fructus Ligustri Lucidi 1-15% and Fructus Lycii 3-20%.
The best proportioning of raw material is: Radix Ginseng 6.6%, the Radix Astragali 13.1%, Herba Hedyotidis Diffusae 9.8%, Herba Scutellariae Barbatae 9.8%, Pseudobulbus Cremastrae Seu Pleiones 4.9%, Rhizoma Curcumae 6.6%, Radix Notoginseng 4.9%, Flos Carthami 4.9%, Semen Coicis 9.8%, Poria 6.6%, Radix Et Caulis Acanthopanacis Senticosi 6.6%, the Rhizoma Atractylodis Macrocephalae 4.9%, Fructus Ligustri Lucidi 4.9% and Fructus Lycii 6.6%.
Its weight can take by weighing like this: Radix Ginseng 3-20g, Radix Astragali 5-30g, Herba Hedyotidis Diffusae 5-30g, Herba Scutellariae Barbatae 5-30g, Pseudobulbus Cremastrae Seu Pleiones 1-15g, Rhizoma Curcumae 3-20g, Radix Notoginseng 1-15g, Flos Carthami 1-15g, Semen Coicis 5-30g, Poria 3-20g, Radix Et Caulis Acanthopanacis Senticosi 3-20g, Rhizoma Atractylodis Macrocephalae 1-15g, Fructus Ligustri Lucidi 1-15g, Fructus Lycii 3-20g.
Tablet, undertaken by following process: (1) is got the Radix Astragali, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Coicis, Poria, Radix Et Caulis Acanthopanacis Senticosi and Fructus Ligustri Lucidi powder and is broken into thick piece, add above 5-15 times of water gaging of each component gross weight, heating decocts 1-3 time, each 1-4 hour, gradation filtered, merging filtrate, be concentrated into the thick paste shape, the relative density of temperature in the time of 50 ℃ is 1.0-1.5; (2) get Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Rhizoma Curcumae, Flos Carthami, Radix Notoginseng and Pseudobulbus Cremastrae Seu Pleiones and be ground into 60-120 purpose fine powder, sieve; (3) ointment that (1) method is made mixes with the medicated powder that (2) method makes, and 50-80 ℃ of drying pulverized, and sieves, and add starch or dextrin and other adjuvant and make granule, drying, granulate adds the compacting of magnesium stearate or other adjuvant in flakes.
Capsule, undertaken by following process: get the ointment that (1) method makes in the above-mentioned method for preparing tablet thereof and mix with the medicated powder that (2) method makes, 50-80 ℃ of drying pulverized, and sieves, and incapsulates to get final product.
Granule, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, and 50-80 ℃ of drying pulverized, and sieves, and adds starch or dextrin and other adjuvant and makes granule.
Powder, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, 50-80 ℃ of drying, pulverizing gets final product.
Pill, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, 50-80 ℃ of drying, be ground into powder, the Mel of the grain weight of getting it filled amount 0-130% boils, filter, it is that the 0-15% ethanol of 40-60% is made pill that medicated powder is added 0-130% Mel and 0-15% water, concentration.
Oral liquid, undertaken by following process: (1) is got the Radix Astragali, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Coicis, Poria, Radix Et Caulis Acanthopanacis Senticosi, Fructus Ligustri Lucidi, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Rhizoma Curcumae, Flos Carthami, Radix Notoginseng and Pseudobulbus Cremastrae Seu Pleiones and is ground into thick piece, add above 5-15 times of water gaging of each component gross weight, heating decocts 1-3 time, each 1-4 hour, gradation filters, and merging filtrate concentrates; (2) concentrated medicament that (1) method is made adds the antiseptic of medicinal liquid gross weight 0.1-1%, the correctives mix homogeneously of 0.1-2%, makes oral liquid.
Syrup, undertaken by following process: (1) gets concentrated medicament by above-mentioned oral liquid preparation technology (1) legal system; (2) sucrose is dissolved in the distilled water that boils, making concentration is the simple syrup of 85% (g/ml) or 64.7% (g/g); (3) concentrated medicament is added in the simple syrup, add an amount of distilled water and make syrup.
Claims (10)
1, a kind of anticancer SHENQI FUZHENG Chinese medicine preparation, it is characterized in that: this Chinese medicine preparation is formulated by following raw materials according percentage ratio by weight: Radix Ginseng 3-20%, Radix Astragali 5-30%, Herba Hedyotidis Diffusae 5-30%, Herba Scutellariae Barbatae 5-30%, Pseudobulbus Cremastrae Seu Pleiones 1-15%, Rhizoma Curcumae 3-20%, Radix Notoginseng 1-15%, Flos Carthami 1-15%, Semen Coicis 5-30%, Poria 3-20%, Radix Et Caulis Acanthopanacis Senticosi 3-20%, Rhizoma Atractylodis Macrocephalae 1-15%, Fructus Ligustri Lucidi 1-15% and Fructus Lycii 3-20%.
2, anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 1 is characterized in that: described raw material is by formulated by the percentage ratio of following weight: Radix Ginseng 6.6%, the Radix Astragali 13.1%, Herba Hedyotidis Diffusae 9.8%, Herba Scutellariae Barbatae 9.8%, Pseudobulbus Cremastrae Seu Pleiones 4.9%, Rhizoma Curcumae 6.6%, Radix Notoginseng 4.9%, Flos Carthami 4.9%, Semen Coicis 9.8%, Poria 6.6%, Radix Et Caulis Acanthopanacis Senticosi 6.6%, the Rhizoma Atractylodis Macrocephalae 4.9%, Fructus Ligustri Lucidi 4.9% and Fructus Lycii 6.6%.
3, anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 1 is characterized in that: described anticancer SHENQI FUZHENG Chinese medicine preparation is tablet, capsule, granule, powder, pill, oral liquid or syrup.
4, the preparation method of anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 3, it is characterized in that: the preparation method of described tablet, undertaken by following process: (1) is got the Radix Astragali, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Coicis, Poria, Radix Et Caulis Acanthopanacis Senticosi and Fructus Ligustri Lucidi powder and is broken into thick piece, add above 5-15 times of water gaging of each component gross weight, heating decocts 1-3 time, each 1-4 hour, gradation filters, merging filtrate is concentrated into the thick paste shape, and the relative density of temperature in the time of 50 ℃ is 1.0-1.5; (2) get Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Rhizoma Curcumae, Flos Carthami, Radix Notoginseng, Pseudobulbus Cremastrae Seu Pleiones and be ground into 60-120 purpose fine powder, sieve; (3) ointment that (1) method is made mixes with the medicated powder that (2) method makes, and 50-80 ℃ of drying pulverized, and sieves, and add starch or dextrin and other adjuvant and make granule, drying, granulate adds magnesium stearate or other adjuvants, and compacting is in flakes.
5, the preparation method of anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 3, it is characterized in that: the preparation method of described capsule, undertaken by following process: get the ointment that (1) method makes in the above-mentioned method for preparing tablet thereof and mix with the medicated powder that (2) method makes, 50-80 ℃ of drying, pulverize, sieve, incapsulate and get final product.
6, the preparation method of anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 3, it is characterized in that: the preparation method of described granule, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, 50-80 ℃ of drying, pulverize, sieve, add starch or dextrin and other adjuvant and make granule.
7, the preparation method of anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 3, it is characterized in that: the preparation method of described powder, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, 50-80 ℃ of drying, pulverizing gets final product.
8, the preparation method of anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 3, it is characterized in that: the preparation method of described pill, undertaken by following process: the ointment of getting (1) method in the above-mentioned method for preparing tablet thereof mixes with the medicated powder that (2) method makes, 50-80 ℃ of drying, be ground into powder, the Mel of the grain weight of getting it filled amount 0-130% boils, and filters, and it is that the 0-15% ethanol of 40-60% is made pill that medicated powder is added 0-130% Mel and 0-15% water, concentration.
9, the preparation method of anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 3, it is characterized in that: the preparation method of described oral liquid, undertaken by following process: (1) is got the Radix Astragali, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Coicis, Poria, Radix Et Caulis Acanthopanacis Senticosi, Fructus Ligustri Lucidi, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Rhizoma Curcumae, Flos Carthami, Radix Notoginseng and Pseudobulbus Cremastrae Seu Pleiones and is ground into thick piece, add above 5-15 times of water gaging of each component gross weight, heating decocts 1-3 time, each 1-4 hour, gradation filters, merging filtrate concentrates; (2) concentrated medicament that (1) method is made adds the antiseptic of medicinal liquid gross weight 0.1-1%, the correctives mix homogeneously of 0.1-2%, makes oral liquid.
10, the preparation method of anticancer SHENQI FUZHENG Chinese medicine preparation according to claim 3 is characterized in that: the preparation method of described syrup, and make by following process: (1) gets concentrated medicament by above-mentioned oral liquid preparation technology (1) legal system; (2) sucrose is dissolved in the distilled water that boils, making concentration is the simple syrup of 85% (g/ml) or 64.7% (g/g); (3) concentrated medicament is added in the simple syrup, add an amount of distilled water and make syrup.
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| CN100348259C (en) * | 2005-11-07 | 2007-11-14 | 胡建平 | Medicine composition for raising immunity and its prepn and application |
| CN100431586C (en) * | 2006-12-08 | 2008-11-12 | 胡冬林 | Chinese herbal capsule for reducing cancerous protuberance and dispelling toxins |
| CN102847064B (en) * | 2012-08-31 | 2014-12-24 | 苏捷 | Chinese herbal medicine used for inhibition of malignant tumor metastasis |
| CN103860660B (en) * | 2012-12-14 | 2016-12-21 | 陕西郝其军制药股份有限公司 | A kind of medicine treating acute and chronic leukemia and preparation method thereof |
| CN104367945A (en) * | 2014-11-06 | 2015-02-25 | 李俊 | Medicine used for assisting interventional therapy of liver cancer |
| CN105535501A (en) * | 2016-01-22 | 2016-05-04 | 宋秀磊 | Traditional Chinese medicine for treating cancer |
| CN106474421B (en) * | 2016-10-11 | 2019-11-08 | 南方医科大学 | A kind of Chinese medicine composition that treating colorectal cancer and its application |
| CN108354184A (en) * | 2017-12-28 | 2018-08-03 | 防城港圣保堂制药有限公司 | A kind of ginseng gorgon euryale seed powder and preparation method thereof for cancer dietotherapy |
| CN109432207A (en) * | 2018-11-09 | 2019-03-08 | 汉寿县新运堂医药科技有限公司 | Nude mice |
| CN111358914A (en) * | 2020-04-07 | 2020-07-03 | 袁能忍 | A composition for treating leukemia, tumor, AIDS and aging, and its application |
| CN114848786B (en) * | 2022-04-29 | 2024-01-16 | 江西永昇制药股份有限公司 | Anticancer and immunity-increasing compound three-ginseng decoction |
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