CN1256083C - Medicine for boosting qi and nourishing blood and its prepatation method - Google Patents

Abstract

The present invention discloses a medicine and a preparation method thereof for benefiting vital energy. The medicine contains (by weight) the following material components: 160 to 380 parts of notoginseng, 360 to 840 parts of astragalus root, 70 to 170 parts of ginseng and 50 to 120 parts of pueraria root. The medicine which can be in the form of capsules, tablets or granules has obvious curative effects on anaemia, recovery weakness and chemotherapy patients.

Description

A kind of vigorate qi and replenish the blood medicine and its production and application

Technical field

The present invention relates to a kind of pharmaceutical composition.More particularly, the present invention is to be the Chinese patent medicine of feedstock production with the Chinese herbal medicine.The invention still further relates to the preparation method and the application of this medicine.

Background technology

Motherland's medical science thinks that the deficiency of vital energy refers to lung spleen deficiency more, and blood deficiency mostly is the conscience deficiency, and lung governing qi department breathes, and heart governing blood and vessels is changed hemopoietic liquid; The spleen has the function to transport and transform nutrients, and water paddy is source of generating QI and blood, and insufficiency of the spleen then source of generating QI and blood lacks, and the power of mistake is given birth in the then change of blood of having a guilty conscience, and liver storing blood is homophony blood again, and deficiency of the liver is then hidden imbalance; Kidney controlling essence storage, essence and blood sharing the same origin.Common clinically deficiency of heart-blood, how long sick qi-blood deficiency syndrome lose system and control, oldaged physically weak, due to the reason such as lose blood, its pathogenesis is the internal organs weakness.In addition, tumour patient through put, leukocyte can reduce in a large number after the chemotherapy.Suchlike symptom presses for the development safe and effective medicine.Wenshan Qihua Co., Ltd., Yunnan Baiyao Pharmaceutical Group's existing " QI and blood health " oral liquid, inconvenience is carried in transportation, and also desirable not enough to QI and blood deficiency patient's curative effect.

Summary of the invention

The objective of the invention is at the deficiencies in the prior art, a kind of medicine of vigorate qi and replenish the blood is provided.This medicament transport is easy to carry, has the effect of strengthening the body resistance, is used for the deficiency of vital energy, blood deficiency, and the disease of QI and blood deficiency especially is applicable to anemia, body void and chemicotherapy patient take after being ill.

Purpose of the present invention is achieved by following technical proposals.

The invention provides a kind of medicine of vigorate qi and replenish the blood, this medicine is made by the raw material that contains following composition by weight: Radix Notoginseng 160～380, the Radix Astragali 360～840, Radix Ginseng 70～170, Radix Puerariae 50～120.

The invention provides a kind of preparation method of medicine of vigorate qi and replenish the blood, this method comprises the step of following order:

(1) Radix Astragali is decocted with water secondary, the decocting that adds 8～12 times of weight for the first time boiled 1.5～2.5 hours, and the decocting that adds 5～7 times of weight for the second time boiled 1～2 hour; Collecting decoction filters, and filtrate is concentrated in right amount.

(2) with after Radix Notoginseng, Radix Ginseng and the Radix Puerariae coarse pulverization, mixing adopts percolation, makes solvent with 50%～70% ethanol, and percolation 20～26 hours, percolate reclaim ethanol to an amount of.

(3) above-mentioned steps (1), (2) gains are merged, being condensed into 50 ℃ of following relative densities is 1.1～1.3 thick paste shape, dry, pulverize, sieve;

(4) with step (3) gains, add appropriate amount of auxiliary materials, mixing, technology is made capsule, tablet or granule routinely.

In order to extract the effective ingredient in the raw material to greatest extent, reduce the proposition of impurity simultaneously again.The present invention adopts the preferred Radix Astragali water extraction of orthogonal test condition, and has compared Radix Notoginseng, Radix Ginseng and Radix Puerariae 60% ethanol percolation and hot reflux extraction process, thereby draws the preparation method that the present invention suits.

The present invention has carried out the pharmacological testing of system to described vigorate qi and replenish the blood medicine, and details are as follows for relevant situation.

Be subjected to the reagent thing: capsule of the present invention, every 0.3g.

Dosage and administration: establish 0.75g/kg and 1.50g/kg two dosage groups, be mixed with solution, irritate stomach and give mice.

The contrast medication: QIXUEKANG KOUFUYE 10ml/ props up, and lot number 960113 is provided by Wenshan Qihua Co., Ltd., Yunnan Baiyao Pharmaceutical Group.

Test material: cyclophosphamide, lot number: 961006, Hualian Pharmaceutical Co., Ltd., Shanghai produces.Immunoglobulin IgG, IgA, IgM test kit, Shanghai Long March medical science company limited is produced.

Laboratory animal: ICR kind mice, the quality certification number: No. the 9716th, the real moving card in Yunnan;

SD kind rat, the quality certification number: No. the 9717th, the real moving card in Yunnan.

Above animal provides by Inst. of Yunnan Baiyao Group Co., Ltd..

A. to " blood deficiency " mice hemoglobin and erythrocytic influence

Get 40 of mices, body weight 24.9 ± 1.7g, male and female dual-purpose.In 10 of mice eye rear vein beard blood-letting, get blood simultaneously and survey mice Hb and RBC counting before the moulding, the next day 5 of each blood-letting, mice Hb and RBC number after getting blood to survey moulding from the mice tail end next day.With the mice group of moulding success, administration according to dosage is continuous once a day 7 days respectively.Hb and RBC value after eyeground vein clump behind the last administration 24h is got blood survey medicine.Experimental result sees Table 1.

Table 1. is to " blood deficiency " mice hemoglobin and erythrocytic influence

Group	Number of animals	Dosage (g/kg)	Before the moulding (X ± SD)		After the moulding (X ± SD)		After the administration (X ± SD)
									Hbg％	RBC ten thousand/mm	Hbg％	RBC ten thousand/mm	Hbg％	RBC ten thousand/mm
			The model contrast	10	Distilled water	16.14±1.28	745±42	12.29±0.93*							613±40	13.78±0.27	660±54
Test group 1	l0	1.50							15.79±0.96	750±32	12.33±1.16	621±36	15.56±0.65	730±37
			Test group 2	10	0.75	15.87±0.95	737±42	12.46±1.04							622±42	14.83±0.67	707±26
Contrast medicine group	10	30ml/kg							15.92±0.60	730±27	12.27±1.27	607±59	14.87±0.64	72l±25

B. to the influence of immunoglobulin content in the immunologic hypofunction mice serum

Get 50 of mices, male and female half and half, body weight 18～22 grams are divided into five groups at random.Each organizes every day, and according to dosage gastric infusion is once, continuous 20 days, in administration the 8th day, except that the normal control group, the surplus group of equal intraperitoneal injection of cyclophosphamide 50mg/kg of mice, the next day once, totally 5 times, in last injection the last three days at interval, pluck eyeball and get blood, centrifuging and taking goes out serum, measures IgG, IgA, IgM (medicine box is provided by Shanghai Long March medical science company limited), and experimental result sees Table 2.

The influence of IgG, IgA, IgM content in the table 2. pair immunologic hypofunction mice serum

Group	Number of animals	Irritate stomach dosage	The cyclophosphamide accumulated dose	Immunoglobulin (g/L) X ± SD
							IgG	IgA	IgM
				Blank	10	Distilled water					0.194±0.012	0.056±0.013	0.291±0.05
The model contrast	10	Distilled water	50mg/kg×5				0.109±0.016	0.045±0.010	0.210±0.04
				Test group 1	l0	0.75g/kg				50mg/kg×5	0.176±0.02	0.048±0.015	0.291±0.05
Test group 2	10	1.50g/kg	50mg/kg×5				0.202±0.018	0.045±0.018	0.285±0.06
				Contrast medicine group	10	30ml/kg				50mg/kg×5	0.187±0.013	0.047±0.02l	0.212±0.06

C. to the influence of immunologic hypofunction murine interleukin counting and index and spleen index

Get 50 of mices, male and female half and half, body weight 18～22g, be divided into five groups at random, each is organized every day and according to dosage irritates stomach once, continuous 20 days, in administration the 8th day, except that the normal control group, the surplus group of equal intraperitoneal injection of cyclophosphamide 50mg/kg of mice, the next day once, totally 5 times, cause murine interleukin to hang down drag, in last injection the last 3 days at interval, pluck eyeball and get blood and carry out numeration of leukocyte, put to death mice and get spleen and weigh, calculate index and spleen index, experimental result sees Table 3.

The influence of table 3. pair immunologic hypofunction murine interleukin counting and index and spleen index

Group	Number of animals	Irritate stomach dosage	Cyclophosphamide	Leukocyte meter (10 9/L) X±SD	Index and spleen index (mg/10g body weight) X ± SD
						Blank	10	Distilled water		5.27±0.72	53.22±9.12
The model contrast	10	Distilled water	50mg/kg×5	1.43±0.34	19.89±3.36
						Test group 1	10	0.75g/kg	50mg/kg×5	1.99±0.35	22.45±3.29
Test group 2	10	1.50g/kg	50mg/kg×5	2.07±0.31	24.84±6.64
						Contrast medicine group	10	30ml/kg	50mg/kg×5	1.86±0.23	24.52±4.59

D. to the antifatigue effect of mice with spleen deficiency

Get 50 of ICR mices, body weight 19～21 grams, male and female half and half are divided into normal control group, model control group, low dosage test group, high dose test group, contrast medicine group at random.Except that the normal control group, all the other four groups are caused administration respectively again behind the model of spleen deficiency earlier.Concrete grammar is only to irritate stomach with 1g/ml Radix Et Rhizoma Rhei decocting liquid 0.7ml/, every day 1 time, and continuous 7 days, stopped to Radix Et Rhizoma Rhei in the 8th day, stomach is according to dosage irritated in beginning, every day 1 time, each 0.6ml/20g, continuous 8 days.Carry out mice swimming with a load attached to the body test behind the last administration 2h, more than 8 seconds, writing time, the results are shown in Table 4 in 16 ± 1 ℃ middle reaches, constant temperature pond to the mouse head submerged.

The influence of table 4. pair mice with spleen deficiency swimming with a load attached to the body time

Group	Number of animals	Irritate stomach dosage	Swimming time (min) X ± SD
				Blank	10	Distilled water	3.67±1.14
The model contrast	10	Distilled water	2.85±0.07
				Test group 1	10	0.75g/kg	3.43±0.96
Test group 2	10	1.50g/kg	3.98±1.21
				Contrast medicine group	10	30ml/kg	3.81±1.10

E. to the influence of murine interleukin after the x-ray bombardment

Get 100 of ICR mices, body weight 18～22 grams, male and female half and half, except that 20 of normal control groups, all the other 80 with high-energy linac irradiation, and exposure dose is 300Ccy, is divided into four groups after the irradiation at random, the same day is gastric infusion according to dosage, every day 1 time, continuous 14 days, get half mice eyeground vein clump of each group and get blood, carry out numeration of leukocyte, the results are shown in Table 5.

The influence of murine interleukin after the table 5. pair x-ray bombardment

Group	Give stomach dosage	Numeration of leukocyte (10 9/L)X±SD
						Number of animals	14 days	Number of animals	21 days
		Blank	Distilled water	10	8.7±2.3					10	8.4±1.4
The model contrast	Distilled water					10	2.8±0.7	10	6.2±1.3
		Test group 1	0.75g/kg	10	2.7±0.6					10	6.5±1.5
Test group 2	1.50g/kg					10	3.7±1.0	10	7.4±1.0
		Contrast medicine group	30ml/kg	10	3.7±1.1					10	6.8±1.3

F. to the antifatigue effect of mice after the x-ray bombardment

Get 50 of ICR mices, body weight 18～22 grams, male and female half and half, except that 10 of normal control groups, the method for all the other 40 above-mentioned experiment E of usefulness is carried out x-ray bombardment, is divided into four groups after the irradiation, the administration of according to dosage dividing into groups the same day, every day 1 time, continuous 21 days.Carry out bear a heavy burden 10% swimming test of mice behind the last administration 2h, mice to head submerged more than 8 seconds, writing time, the results are shown in Table 6 in 25 ± 0.5 ℃ middle reaches, constant temperature pond.

The influence of table 6. pair x-ray bombardment mice swimming with a load attached to the body

Group	Number of animals	Dosage	Swimming time (min) X ± SD
				Blank	10	Distilled water	10.63±3.58
The model contrast	10	Distilled water	9.98±2.05
				Test group 1	10	0.75g/kg	9.60±3.06
Test group 2	10	1.50g/kg	12.93±3.87
				Contrast medicine group	10	30ml/kg	12.83±3.51

G. to the influence of mice normal pressure anoxia enduring

Get 40 of mices, male and female half and half, body weight 20～24g divides equally four groups at random, each organize according to dosage every day gastric infusion once, continuous 7 days, half an hour after the last administration, put mice respectively in the 150ml wide mouthed bottle, place the soda lime 5g that filter paper encases in the bottle, the sealing bottleneck is observed the mice time-to-live, result such as table 7.

The influence of table 7. pair mice normal pressure anoxia enduring

Group	Number of animals	Dosage	Time-to-live (second) X ± SD
				Blank	10	Distilled water	473.50±35.67
Contrast medicine group	10	30ml/kg	514.17±44.57
				Test group 1	10	0.75g/kg	523.32±64.50
Test group 2	10	1.50g/kg	520.83±52.89

Above-mentioned pharmacological tests shows that medicine of the present invention gives mice with 0.75g/kg and 1.50g/kg (being equivalent to crude drug 2.68g/kg and 5.37g/kg), and hemoglobin and the erythrocyte of " blood deficiency " mice had remarkable restitution; Decline can be resisted, numeration of leukocyte and the index and spleen index of the mice of caused by cyclophosphamide immunologic hypofunction can be significantly improved because of immunoglobulin IgG in the injection caused by cyclophosphamide mice serum; 1.50g/kg dosage can make the mice with spleen deficiency due to the Radix Et Rhizoma Rhei down, prolongs the swimming with a load attached to the body time, and the enhancing antifatigue effect is arranged.Murine interleukin after making x-ray bombardment under this dosage raises, and can significantly improve mice normal pressure hypoxia-bearing capability.Simultaneously, main pharmacodynamics studies confirm that the present invention has kept original physiologically active of QIXUEKANG KOUFUYE, provides the pharmacodynamics foundation for its dosage form changes.

The present invention has further done clinical trial on the basis of above-mentioned pharmacological testing, details are as follows for relevant situation.

A. overview: medicine of the present invention through First People's Hospital, Yunnan Province, Traditional Chinese Medical Hospital, Yunnan Prov., Yunnan Province red can hospital and Yunnan Cancer Hospital carried out the clinical verification observation.By clinical verification observe pale complexion, shortness of breath and fatigue that syndrome of deficiency of heart blood and deficiency of both QI and blood showed, feel dizzy, the curative effect of cardio palmus, its safety of examination of holding concurrently.

B. case history is gone into the group standard: observe case 160 examples altogether, and adopt the completely random technology will observe case, be divided into two groups of checking group and matched groups, wherein 100 examples are organized in treatment, matched group 60 examples.Male patient 32 people in the test group, female patient 68 people; Maximum 65 years old age, minimal ages 21 years old, 52.4 years old mean age; The longest course of disease 5 years, the shortest course of disease February, average course of disease 1.7 years; Syndrome of deficiency of heart blood 34 examples, QI and blood deficient syndrome 66 examples.Male 22 examples in the matched group, women 38 examples; Maximum 65 years old age, minimal ages 21 years old, 50.8 years old mean age; The longest course of disease 4 years, the shortest course of disease February, average course of disease 1.7 years; Syndrome of deficiency of heart blood 18 examples, asthenia of qi and blood 42 examples.

C. method of administration:

Test group is taken capsule of the present invention, and each 3, every day 2 times, be 4 weeks the course of treatment.

Matched group: QIXUEKANG KOUFUYE, each 20 milliliters, every day 2 times.

D. Chinese medical discrimination standard:

Syndrome of deficiency of blood Chinese medical discrimination in deficient can be divided into deficiency of heart-blood, deficiency of liver-blood, QI and blood deficiency and asthenia of essence and blood four cards, and syndrome of deficiency of heart blood and deficiency of both QI and blood are selected in this checking.

Syndrome of deficiency of heart blood: pale complexion, dizziness and blurred vision, lip pale tongue, cardiopalmus, insomnia, dreaminess, light red, the thready and weak pulse of body of the tongue.

Deficiency of both QI and blood: pale complexion, dizziness and blurred vision, lip pale tongue, weak breath, lazy speech, spiritlessness and weakness, forgetful, indigestion and loss of appetite, loose stool, light red, the thready and weak pulse of body of the tongue.

E. health giving quality observation:

1. the improvement situation of symptom and pulse condition, picture of the tongue;

2. the comparison before and after the treatment of hemogram index: red blood cell count(RBC) (RBC), hemoglobin (HGB), platelet count (PLT), numeration of leukocyte (WBC).

3. side effect is observed: in the clinical verification, in case find toxic and side effects, with drug withdrawal immediately and take corresponding emergency treatment, and record faithfully.

F. clinical implementation scheme

This checking is adopted to be in hospital and is combined with the observation of outpatient service fixed-point system, and strict control variable factor does not add with other similar medicine, uses this checking medicine and control drug merely.

G. efficacy evaluation:

1. produce effects: card marquis, arteries and veins, picture of the tongue obviously improve, hemogram has multiple liter.

2. effective: card marquis, arteries and veins, picture of the tongue have certain improvement, hemogram that improvement is arranged slightly and have part index number to rise again.

3. invalid: card marquis, arteries and veins, picture of the tongue all do not have improvement, hemogram does not have significant change, even reduce.

H. result of the test: see Table 8. table 9. table 10. table 11. table 12. tables 13.

Table 8. patient observation of curative effect relatively

Group	Produce effects		Effectively		Invalid		Add up to
								The example number	％	The example number	％	The example number	％
	Test group	32	32.00	61	61.00	7								7.00	100
Matched group							7	11.67	45	75.00	8	13.33	60

* through rank test, u=2.9448, there is the utmost point significant difference P＜0.01.

Table 9. patient total effects is observed relatively

Group	Effectively total		Invalid		Add up to
						The example number	％	The example number	％
	Test group	93	93.00	7						7.00	100
Matched group					52	86.67	8	13.33	60

Annotate: effectively total=produce effects+effectively through X 2 test,

X ²＝1.7704，P＞0.05

Table 10. patient pattern of syndrome observation of curative effect

Pattern of syndrome	Group	Produce effects		Effectively		Invalid		Add up to
									The example number	％	The example number	％	The example number	％
		Syndrome of deficiency of heart blood	Test group	8	23.53	23	67.65								3	8.82	34
Matched group	2							11.11	13	72.22	3	16.67	18
			* deficiency of both QI and blood	Test group	22	33.33	40							60.61	4	6.06	66
Matched group	5	11.90						32	76.20	5	11.90	42

* two groups through rank test, u=2.5271, and there were significant differences in P＜0.05

The curative effect of table 11. pair unusual hemogram

Project	Before the treatment	After the treatment	t	The P value
					Erythrocyte	4.36±0.68	4.65±0.77	2.4997	＜0.05
Leukocyte	5.76±1.61	5.81±1.48	0.2275	＜0.05
					Hematochrome	12.47±2.34	12.86±2.20	1.2553	＞0.05
Platelet	159.43±37.90	160.83±38.87	0.2566	＞0.05

Table 12. pair is put, total white blood cells is relatively before and after the patients undergoing chemotherapy treatment

Group	The example number	Before the treatment (X ± SD)	The treatment back (X ± SD)	Difference
					Test group	30	3.30±0.49	5.11±1.22	1.81±1.42
Matched group	30	3.34±1.20	4.94±1.16	1.60±1.51

Table 13. pair is put, patients undergoing chemotherapy leukopenia curative effect relatively

Group	Curative effect				Obvious effective rate (%)	Total effective rate (%)
							Produce effects	Effectively	Invalid	Add up to
	Test group	26	3	1							30	86.67	96.67
Matched group					22	5	3	30	73.33	90.00

Above result of the test shows that the present invention has following beneficial effect:

1. to select natural plant for use be raw material in the present invention, and prescription and technology are reasonable, and dosage form is preserved, transportation is carried, taking convenience, and each composition complements each other and receives good combined therapy effect., diet unusual to dizziness and blurred vision, cardiopalmus, lassitude, insomnia, color of the lip, complexion differs from 7 curative effects such as symptom and all is better than contrasting medicine.Clinical patients there is no side reaction at period in a medicine and takes place, and shows that medicine of the present invention has higher safety.

2. the present invention has beat all effect to the curative effect of deficiency of both QI and blood, and patient's proportion that significant curative effect is arranged in the test group is 33.33%, and matched group only is 11.90%; Inefficacy person's proportion (6.06%) then is lower than matched group (11.90%), shows that medicine of the present invention is better than contrasting the medicine QIXUEKANG KOUFUYE to the deficiency of both QI and blood curative effect.

3. the routine blood test comparative result shows before and after the treatment, and red blood cell count(RBC) is learned check by statistics, and there were significant differences in P＜0.05, points out medicine of the present invention to have the erythrocytic effect of certain lifting.

Through Yunnan Cancer Hospital 30 examples are put, leukopenic patient after the chemotherapy, self observes relatively before and after treating, medicine of the present invention has the effect of leukocyte increasing sum preferably, has indicated good prospect in medicine.

The specific embodiment

By specific embodiment given below, can further be well understood to the present invention.But they are limitation of the invention not.

Embodiment 1

Get Radix Astragali 500g, decoct with water twice, the decocting that adds 10 times of amounts for the first time boiled 2 hours, added 7 times of water gagings for the second time and decocted 1.5 hours, and collecting decoction filters, and filtrate is concentrated in right amount.Other gets Radix Notoginseng 225g, and Radix Ginseng 100g, Radix Puerariae 70 grams mix after the coarse pulverization, according to " percolation under Chinese pharmacopoeia appendix fluid extract of version in 2000 and the extractum item is made solvent with 50% ethanol, percolation slowly, and diacolation liquid recycling ethanol is in right amount; Merge above-mentioned two kinds of medicinal liquids, being condensed into relative density is the extractum of 1.12～1.16 (under 50 ℃～60 ℃), and spray drying adds starch 15g, microcrystalline Cellulose 20g, and mixing in the capsulae vacuus of packing into, is made 1000, promptly gets capsule preparations of the present invention.

Embodiment 2

Get Radix Astragali 700g, decoct with water twice, the decocting that adds for the first time 8 times of amounts boiled 2 hours, added 5 times of water gagings for the second time and decocted collecting decoction 1 hour, filter, filtrate is concentrated in right amount, and other gets Radix Notoginseng 315g, Radix Ginseng 140g, Radix Puerariae 98g, mix after the coarse pulverization, according to " percolation under Chinese pharmacopoeia appendix fluid extract of version in 2000 and the extractum item is made solvent with 70% ethanol, slowly percolation, diacolation liquid recycling ethanol is to an amount of, merge above-mentioned two kinds of medicinal liquids, being condensed into relative density is the extractum of 1.20～1.30 (under 50 ℃～60 ℃), adds starch 20 grams, microcrystalline Cellulose 10g, dextrin 10g, after mixing is spared all, make granule, drying is pressed into 1000, coating promptly gets tablet of the present invention.

Embodiment 3

Repeat embodiment 2, following difference is arranged: after being condensed into extractum, with soluble starch 300 grams, Icing Sugar 1000 grams behind the mix homogeneously, are made granule, drying, and packing promptly gets granule of the present invention.

Claims (6)

1. vigorate qi and replenish the blood medicine, the raw material that it is characterized in that making this pharmaceutically active ingredient forms and weight portion is: 50～120 parts of 160～380 parts of Radix Notoginseng, 360～840 parts of the Radixs Astragali, 70～170 parts of Radix Ginsengs and Radix Puerariaes.

2. vigorate qi and replenish the blood medicine according to claim 1, the raw material that it is characterized in that making this pharmaceutically active ingredient forms and weight portion is: 84 parts of 270 parts of Radix Notoginseng, 600 parts of the Radixs Astragali, 120 parts of Radix Ginsengs and Radix Puerariaes.

3. vigorate qi and replenish the blood medicine according to claim 1 and 2, the dosage form that it is characterized in that medicine is capsule, tablet or granule.

4. the preparation method of the described vigorate qi and replenish the blood medicine of claim 1 steps of the method are:

(1) Radix Astragali is decocted with water secondary, the decocting that adds 8～12 times of weight for the first time boiled 1.5～2.5 hours, and the decocting that adds 5～7 times of weight for the second time boiled 1～2 hour; Collecting decoction filters, and filtrate is concentrated in right amount;

(2) Radix Notoginseng, Radix Ginseng and powder of Radix Puerariae are broken into coarse powder, mixing adopts percolation, makes solvent with 50%～70% ethanol, and percolation 20～26 hours, percolate reclaim ethanol to an amount of;

(3) gains of above-mentioned steps (1) and (2) are merged, being condensed into 50 ℃ of following relative densities is 1.1～1.3 thick paste shape, dry, pulverize, sieve;

(4) with above-mentioned steps (3) gains, add appropriate amount of auxiliary materials, mixing, technology is made capsule, tablet or granule routinely.

5. the described vigorate qi and replenish the blood medicine of claim 1 is in preparation treatment or prevention anemia, the application in the medicine of body void after being ill.

6. the described vigorate qi and replenish the blood medicine of claim 1 is put in preparation treatment or prevention, chemotherapy causes the application in leukopenic medicine.