CN1857690A - Gynecopathy treating preparation and its preparing process - Google Patents
Gynecopathy treating preparation and its preparing process Download PDFInfo
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- CN1857690A CN1857690A CNA2006100728461A CN200610072846A CN1857690A CN 1857690 A CN1857690 A CN 1857690A CN A2006100728461 A CNA2006100728461 A CN A2006100728461A CN 200610072846 A CN200610072846 A CN 200610072846A CN 1857690 A CN1857690 A CN 1857690A
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to Chinese medicine composition, and especially a kind of Chinese medicine composition for treating menstrual period disorder dysmenorrhea, leuhorrhagia with reddish discharge, hypochondriac distress and pain, listlessness and food deficiency and its preparation process. The Chinese medicine composition is preferably prepared into tablet and capsule.
Description
Technical field:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, particularly a kind of treatment gynaecopathia preparation is by Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Leonuri, the Radix Astragali (processed with honey), Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Atractylodis, Poria, Colla Corii Asini (Pulvis concha Mactrae scalds), Radix Polygoni Multiflori (black soya bean wine is processed), Fructus Psoraleae (salt is processed), Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae (salt is processed), Fructus Evodiae (Radix Glycyrrhizae is processed), Halloysitum Rubrum (forging quench in vinegar), charred Cortex Eucommiae, Endoconcha Sepiae, Concha Ostreae (forging), Fructus Cnidii, dried Alumen, Cortex Ailanthi (parched with bran), MUZHUA, Radix Clematidis, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Rhizoma Ligustici, Radix Dipsaci, Radix Cyathulae, Radix Bupleuri, Rhizoma Corydalis (processed with vinegar), Radix Curcumae, Rhizoma Cyperi (processed with vinegar), Cortex Moutan, Fructus Amomi Rotundus core, Fructus Amomi, Exocarpium Citri Grandis, Pericarpium Citri Reticulatae Viride (process with vinegar), Rhizoma Pinelliae Preparatum, charred Folium Artemisiae Argyi, Rhizoma Acori Graminei, Radix Polygalae (coring, Radix Glycyrrhizae is processed), Semen Ziziphi Spinosae (stir-fry), Fructus Quisqualis, Rhizoma Picrorhizae, Rhizoma Coptidis, Radix Scutellariae, Semen Nelumbinis (removing the heart), Radix Glycyrrhizae is formed and preparation technology.
Background technology:
Menoxenia is meant the cycle, menstrual period of menstruation, unusual through amount and chromaticness aspect, comprise preceeded menorrhea, delayed menstrual cycle, menstruation irregularly successively, diseases such as menorrhagia and hypomenorrhea.Identical with the diseases such as dysfunctional uterine hemorrhage of modern medicine, be a kind of common clinical syndrome.Doctor trained in Western medicine thinks that menoxenia belongs to endocrine more and slightly lacks of proper care, and this disease is lacked effective Therapeutic Method.
The women is this with blood, with blood is usefulness, because women's the physiology and the characteristic of pathology, hematozemia very easily, general women's menstruation in average every month will be lost blood 30 milliliters, and 15 milligrams of loss ferrum equal to lose every day 0.5 milligram of ferrum, add gestation, childbirth, suckling, artificial abortion, fetal abortion abortion and gynecilogical operation etc., then the loss of ferrum element amount is more.Therefore, the women needs manyly to the ferrum element demand than the man on physiological mechanism.Ferrum element is the nutrient substance of needed by human, also is indispensable material base in tissue metabolism's process, also is the material base of making the hemoglobin in the erythrocyte, is the trace element that replenishes the essential picked-up of iron deficiency anemia.Motherland's medical science is thought: blood being the material foundation of QI, and qi being the governor of blood, the blood ventilation is suitable, and qi depression to blood stasis complements each other between them, causes visceral dysfunction.If ischemia is too much, then can cause disorder of QI and blood, Qi and blood deficiency in the human female, cause dizziness and blurred vision, a series of ill symptomses such as pallor is simple and unadorned, cardiopalmus is weak, menoxenia, dysmenorrhea.
The precious golden preparation of woman derives from the precious Jindan of ministry standard Chinese traditional patent formulation preparation woman through extracting refining forming.The precious golden ball of woman is by the BAZHEN TANG exhibition of spreading out, the onset of tradition honey pill agent is slow, technology is original, the precious golden ball of existing woman exists dose big, take inconvenience, absorb slow, pack, carry, transport, preserve shortcoming such as also inconvenience, limited the production and the application of this medicine, more limited it and entered the international market.The precious preparation of woman adopts advanced extraction process, when having extracted the effective site and effective ingredient in the Chinese crude drug fully, has rejected a large amount of impurity, has both satisfied characteristics such as modern Chinese medicine is efficient, dosage is little, five convenience.After changing other preparation into by pill, drug level height, volume are urinated and are carried in taking, and are convenient to store advantages such as good stability.Fill blood with BAZHEN TANG in the side and be the basis, add Herba Leonuri, Rhizoma Corydalis, Cortex Moutan nourshing blood and promoting blood circulation regulating menstruation, add Colla Corii Asini, Radix Polygoni Multiflori, the Radix Astragali, tonifying liver replenishing QI and blood, the merit of benefiting QI and nourishing blood regulating menstruation is played in Radix Cyathulae, Radix Dipsaci, Fructus Psoraleae the kidney invigorating altogether with strong unit down and BAZHEN TANG; Fructus Evodiae, Rhizoma Cyperi, the Fructus Amomi machine of regulating the flow of vital energy; Increase into Cornu Cervi Degelatinatum, Cortex Cinnamomi, Ramulus Cinnamomi, Folium Artemisiae Argyi, Fructus Alpiniae Oxyphyllae charcoal warming the meridian is supporing yang with warm palace; The merit of Rhizoma Ligustici, the Radix Angelicae Dahuricae, Cortex Ailanthi, Fructus Cnidii, Fructus Chaenomelis, Radix Clematidis, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis dispelling wind and easing pain, dehumidifying, the yang invigorating gas of holding concurrently pushes up in the mountain peak; Fructus Amomi Rotundus core, Fructus Amomi, Exocarpium Citri Grandis, Pericarpium Citri Reticulatae Viride, Rhizoma Pinelliae Preparatum invigorating the spleen and regulating the stomach; Radix Polygalae, Rhizoma Acori Graminei, Semen Ziziphi Spinosae, Fructus Quisqualis, Semen Nelumbinis tranquilizing the mind; Halloysitum Rubrum, charred Cortex Eucommiae, Endoconcha Sepiae, dried Alumen are directly gone into the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the loss of astringent therapy leukorrhagia; Rhizoma Picrorhizae, Rhizoma Coptidis, Radix Scutellariae heat clearing away are in case production of dryness-heat in the interior, and all medicines are harmonious, and play vigorate qi and replenish the blood altogether, blood stasis dispelling, damp eliminating, the merit of wind and heat dispersing.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicinal granule that has no side effect, chewable tablet, capsule, tablet, its medicament that makes can be used for curing mainly the not irregular menstrual period of Shu Yinqi of deficiency of vital energy cold in blood, stagnation of liver-QI, menalgia, leucorrhea with red and white discharge, two side of body distending pains, the asthenia lack of appetite.
Summary of the invention:
The gynopathic Chinese medicine preparation of a kind of treatment, it is characterized in that per 1000 dosage units are made by the following weight proportion raw material: 20～80 parts of Radix Angelicae Sinensis, 8～32 parts of Rhizoma Chuanxiongs, 20～80 parts of the Radix Paeoniae Albas, 8～32 parts of Radix Rehmanniae, 8～32 parts of Radix Rehmanniae Preparata, 8～32 parts of Herba Leonuris, 8～32 parts of the Radixs Astragali (processed with honey), 24～96 parts of Radix Codonopsis, 20～80 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 6～24 parts of Rhizoma Atractylodis, 8～32 parts in Poria, 12～48 parts in Colla Corii Asini (Pulvis concha Mactrae scalds), 8～32 parts of Radix Polygoni Multiflori (black soya bean wine is processed), 8～32 parts of Fructus Psoraleaes (salt is processed), 2～8 parts of Ramulus Cinnamomi, 8～32 parts of Fructus Alpiniae Oxyphyllae (salt is processed), 10～40 parts of Fructus Evodiaes (Radix Glycyrrhizae is processed), 5～20 parts of Halloysitum Rubrums (forging quench in vinegar), 12～48 parts of charred Cortex Eucommiaes, 8～32 parts of Endoconcha Sepiaes, 4～16 parts of Concha Ostreaes (forging), 12～48 parts of Fructus Cnidiis, 8～32 parts of dried Alumens, 8～32 parts of Cortex Ailanthis (parched with bran), 8～32 parts of MUZHUA, 8～32 parts of Radix Clematidis, 11～44 parts of Radix Gentianae Macrophyllae, 4～16 parts of Rhizoma Et Radix Notopterygiis, 4～16 parts of Radix Angelicae Pubescentiss, 4～16 parts of the Radixs Angelicae Dahuricae, 10～40 parts of Rhizoma Ligusticis, 8～32 parts of Radix Dipsacis, 4～16 parts of Radix Cyathulaes, 20～80 parts of Radix Bupleuri, 8～32 parts of Rhizoma Corydalis (processed with vinegar), 8～32 parts of Radix Curcumaes, 16～64 parts of Rhizoma Cyperis (processed with vinegar), 4～16 parts of Cortex Moutans, 1～4 part of Fructus Amomi Rotundus core, 1～4 part of Fructus Amomi, 4～16 parts of Exocarpium Citri Grandises, 6～24 parts of Pericarpium Citri Reticulatae Viride (process with vinegar), 6～24 parts of Rhizoma Pinelliae Preparatum, 8～32 parts of charred Folium Artemisiae Argyis, 36～144 parts of Rhizoma Acori Graminei, 6～24 parts of Radix Polygalaes (coring, Radix Glycyrrhizae is processed), 8～32 parts of Semen Ziziphi Spinosaes (stir-fry), 8～32 parts of Fructus Quisqualis, 4～32 parts of Rhizoma Picrorhizae, 4～32 parts of Rhizoma Coptidis, 6～24 parts of Radix Scutellariaes, 80～320 parts in Semen Nelumbinis (removing the heart), 4～16 parts in Radix Glycyrrhizae.
Preferably:
40 parts of Radix Angelicae Sinensis, 16 parts of Rhizoma Chuanxiongs, 40 parts of the Radix Paeoniae Albas, 16 parts of Radix Rehmanniae, 16 parts of Radix Rehmanniae Preparata, 16 parts of Herba Leonuris, 16 parts of the Radixs Astragali (processed with honey), 48 parts of Radix Codonopsis, 40 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 12 parts of Rhizoma Atractylodis, 16 parts in Poria, 24 parts in Colla Corii Asini (Pulvis concha Mactrae scalds), 16 parts of Radix Polygoni Multiflori (black soya bean wine is processed), 16 parts of Fructus Psoraleaes (salt is processed), 4 parts of Ramulus Cinnamomi, 16 parts of Fructus Alpiniae Oxyphyllae (salt is processed), 20 parts of Fructus Evodiaes (Radix Glycyrrhizae is processed), 10 parts of Halloysitum Rubrums (forging quench in vinegar), 24 parts of charred Cortex Eucommiaes, 16 parts of Endoconcha Sepiaes, 8 parts of Concha Ostreaes (forging), 24 parts of Fructus Cnidiis, 16 parts of dried Alumens, 16 parts of Cortex Ailanthis (parched with bran), 16 parts of MUZHUA, 16 parts of Radix Clematidis, 22 parts of Radix Gentianae Macrophyllae, 8 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Radix Angelicae Pubescentiss, 8 parts of the Radixs Angelicae Dahuricae, 20 parts of Rhizoma Ligusticis, 16 parts of Radix Dipsacis, 8 parts of Radix Cyathulaes, 40 parts of Radix Bupleuri, 16 parts of Rhizoma Corydalis (processed with vinegar), 16 parts of Radix Curcumaes, 32 parts of Rhizoma Cyperis (processed with vinegar), 8 parts of Cortex Moutans, 1.6 parts of Fructus Amomi Rotundus cores, 1.6 parts of Fructus Amomis, 8 parts of Exocarpium Citri Grandises, 12 parts of Pericarpium Citri Reticulatae Viride (process with vinegar), 12 parts of Rhizoma Pinelliae Preparatum, 16 parts of charred Folium Artemisiae Argyis, 72 parts of Rhizoma Acori Graminei, 12 parts of Radix Polygalaes (coring, Radix Glycyrrhizae is processed), 16 parts of Semen Ziziphi Spinosaes (stir-fry), 16 parts of Fructus Quisqualis, 8 parts of Rhizoma Picrorhizae, 8 parts of Rhizoma Coptidis, 12 parts of Radix Scutellariaes, 160 parts in Semen Nelumbinis (removing the heart), 8 parts in Radix Glycyrrhizae.
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 in tablet, 1000 of capsules, granule 1000g etc. also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be granule, chewable tablet, tablet, effervescent tablet, effervescent granule.
Described extraction process prepares through following steps:
(1) Semen Nelumbinis powder of getting Poria, Colla Corii Asini (Pulvis concha Mactrae scalds), charred Cortex Eucommiae, Endoconcha Sepiae, Concha Ostreae (forging), dried Alumen, Cortex Moutan, charred Folium Artemisiae Argyi and 60 parts is broken into fine powder, and is standby.
(2) getting Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Herba Leonuri, Fructus Evodiae (Radix Glycyrrhizae is processed), Rhizoma Ligustici, Rhizoma Corydalis (processed with vinegar), Rhizoma Picrorhizae, Rhizoma Coptidis adds ethanol and carries out reflux, extract, twice, the alcohol solvent consumption is 4～10 times of medical material amount, concentration of alcohol is 50～90%, return time 0.5～2.0 hour.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with medicinal residues behind the above ethanol extraction and remaining Semen Nelumbinis and Radix Rehmanniae, Radix Rehmanniae Preparata, the Radix Astragali (processed with honey), Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Atractylodis, Radix Polygoni Multiflori (black soya bean wine is processed), Fructus Psoraleae (salt is processed), Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae (salt is processed), Halloysitum Rubrum (forging quench in vinegar), Fructus Cnidii, Cortex Ailanthi (parched with bran), MUZHUA, Radix Clematidis, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix Dipsaci, Radix Cyathulae, Radix Bupleuri, Radix Curcumae, Rhizoma Cyperi (processed with vinegar), Fructus Amomi Rotundus core, Fructus Amomi, Exocarpium Citri Grandis, Pericarpium Citri Reticulatae Viride (process with vinegar), Rhizoma Pinelliae Preparatum, Rhizoma Acori Graminei, Radix Polygalae (coring, Radix Glycyrrhizae is processed), Semen Ziziphi Spinosae (stir-fry), Fructus Quisqualis, Radix Scutellariae, twice of Radix Glycyrrhizae extracting in water, amount of water is 4～10 times, each extraction time is 0.5～3 hour, collect volatile oil during extraction simultaneously, volatile oil is standby; Merge extractive liquid,, filter, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 8～48 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, the water extracting alcohol hypostasis.
Through described raw material is extracted processing, obtain each extract part, add suitable adjuvant as required and make, ethanol extraction, water extract and volatile oil lump together the active constituents of medicine into preparation of the present invention.
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule; The preparation process of capsule is as follows: with above-mentioned extract obtained, granulate with medicated powder, add lubricant and fill, promptly get capsule; The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from water Fructus Citri sinensis powdered flavor, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, stevioside, Mentholum, the Oleum menthae or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the influence of white mice developing womb
Get the female white mice of Kunming kind, body weight 18～22g, 30,10 every group, blank group (equivalent distilled water), the precious gold group of woman (0.18g/kg), NVJINDAN PIAN (12g/kg), gastric infusion, once a day, continuous 15 days, weigh in the 16th day animal, put to death.Win the uterus and ovary is weighed at ten thousand/balance rapidly, and be converted into organ index, observe of the influence of this extractum Mouse Uterus and ovary.
The influence of table 1 pair white mice developing womb (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | Uterus/body weight (mg/10g) | Ovary/body weight (mg/10g) |
| The precious gold group of matched group woman NVJINDAN PIAN | - 0.18 12 | 10 10 10 | 12.0±2.6 10.8±2.0 11.2±1.9 | 5.1±1.2 5.9±1.7 5.4±1.4 |
Data show in the table, and the precious gold group of woman compares difference that there are no significant with blank group and positive controls.
2, to the analgesic activity of white mice
Getting body weight is female 40 of 18～22g Kunming kind white mice, is divided into 4 groups at random, and 10 every group, grouping and medication are the same.Every day gastric infusion once, continuous five days, after last administration 30 minutes lumbar injection 0.05% antimony tartrate potassium solution 0.2ml/ only, each treated animal is turned round the body number of times by what antimony potassium tartrate caused in the observed and recorded 30 minutes.Result of the test sees Table 2.
The analgesic activity of table 2 pair white mice (x ± s)
| Group | Dosage (g/kg) | Number of animals (only) | Turn round the body number of times | The P value |
| The precious gold group of matched group woman NVJINDAN PIAN | - 0.18 12 | 10 10 10 | 27.8±8.1 11.8±9.6 12.5±9.4 | - ＜0.01 ＜0.01 |
The result shows that precious gold group of woman and positive controls can obviously reduce white mice and turn round the body number of times, and the effect of obvious suppression pain is arranged.
3, young female rat induced ovulation is reached the influence that corpus luteum is formed
The results are shown in Table 3.
Table 3 pair young female rat induced ovulation and influence that corpus luteum is formed (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Number of eggs ovulated (individual) | Corpus luteum number (individual) |
| The precious gold group of normal saline group ovulation model group clomiphene group woman | 10 10 10 10 | - 15IUHCG 0.005 0.13 | 0 22.20±6.03 △△ 30.90±9.96 ** 33.20±10.00 ** | 0 12.85±6.10 △△ 14.45±7.15 ** 10.60±4.61 ** |
Annotate: model group and normal saline group compare,
△ △P＜0.01 administration group and matched group are relatively
*P＜0.05;
*P＜0.01 result shows, the normal saline group is not seen ovulation, all have ovulation to take place by each treated animal of gastric infusion, the precious gold group of woman more all has significant difference (P＜0.01) with the ovulation model group, shows that the precious gold group of woman has obvious ovulation effect to the young female rat.Normal saline matched group ovary is not seen corpus luteum under mirror, and each treated animal of administration all has corpus luteum to form, but there was no significant difference between each administration group, the precious gold of prompting woman forms no obvious dependency to corpus luteum.
4, to the influence of young female mouse vagina superficial cell
Get 30 of body weight 29.53 ± 2.65g female mices, be divided into three groups at random, i.e. normal saline group, estradiol group (0.03ml/ is only), the precious gold group of woman (0.18g/kg), administering mode is for irritating stomach, and successive administration seven days the results are shown in Table 4.
The influence of table 4 pair young female mice superficial cell (x ± s)
| Group | The epithelial influence of keratinization after the administration/ | ||||||
| The 1st day | The 2nd day | The 3rd day | The 4th day | The 5th day | The 6th day | The 7th day | |
| The precious gold group of normal saline group estradiol group woman | 1.70±1.25 55.30±0.71 33.50±22.29 | 1.20±0.79 65.40±11.63 56.90±31.55 | 2.10±1.66 94.96±8.06 76.30±26.12 | 1.40±1.26 92.10±6.76 71.20±24.93 | 1.20±0.92 97.10±2.79 52.90±28.15 | 1.40±1.07 90.00±13.19 50.10±26.94 | 2.50±1.23 81.60±20.89 50.60±27.78 |
The result shows, mirror is observed down behind the animal via vaginal smear, normal saline control animals superficial cell number is less, the more estradiol group of leukocyte, the precious gold group of woman, the vaginal smear mirror shows that down a large amount of superficial cells generate, each group more all has significant difference (P＜0.01) with the normal saline matched group, and the precious gold group of prompting woman has the effect that improves young female mice body inner estrogen level.
5, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are sensation of oppression over the chest with shortness of breath, the anginal medicines that a kind of good treatment coronary insufficiency causes, and change preparation technology, can obviously strengthen clinical efficacies such as its blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The precious golden capsular preparation of woman:
(1) get Poria 16g, Colla Corii Asini (Pulvis concha Mactrae scalds) 24g, charred Cortex Eucommiae 24g, Endoconcha Sepiae 16g, Concha Ostreae (forging) 8g, dried Alumen 16g, Cortex Moutan 8g, charred Folium Artemisiae Argyi 16g, Semen Nelumbinis (removing the heart) 60g are ground into fine powder, and be standby.
(2) get Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 16g, Radix Paeoniae Alba 40g Herba Leonuri 16g, Fructus Evodiae (Radix Glycyrrhizae is processed) 20g, Rhizoma Ligustici 20g, Rhizoma Corydalis (processed with vinegar) 16g, Rhizoma Picrorhizae 8g, Rhizoma Coptidis 8g add 85% ethanol and carry out reflux, extract, twice, the alcohol solvent consumption is 7 times of amounts, 5 times of amounts, and reflux extracting time is 2.0 hours, 1.5 hours.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with medicinal residues behind the above ethanol extraction and remaining Semen Nelumbinis 100g and Radix Rehmanniae 16g, Radix Rehmanniae Preparata 16g, the Radix Astragali (processed with honey) 16g, Radix Codonopsis 48g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 40g, Rhizoma Atractylodis 12g, Radix Polygoni Multiflori (black soya bean wine is processed) 16g, Fructus Psoraleae (salt is processed) 16g, Ramulus Cinnamomi 4g, Fructus Alpiniae Oxyphyllae (salt is processed) 16g, Halloysitum Rubrum (forging quench in vinegar) 10g, Fructus Cnidii 24g, Cortex Ailanthi (parched with bran) 16g, MUZHUA 16g, Radix Clematidis 16g, Radix Gentianae Macrophyllae 22g, Rhizoma Et Radix Notopterygii 8g, Radix Angelicae Pubescentis 8g, Radix Angelicae Dahuricae 8g, Radix Dipsaci 16g, Radix Cyathulae 8g, Radix Bupleuri 40g, Radix Curcumae 16g, Rhizoma Cyperi (processed with vinegar) 32g, Fructus Amomi Rotundus core 1.6g, Fructus Amomi 1.6g, Exocarpium Citri Grandis 8g, Pericarpium Citri Reticulatae Viride (process with vinegar) 12g, Rhizoma Pinelliae Preparatum 12g, Rhizoma Acori Graminei 72g, Radix Polygalae (coring, Radix Glycyrrhizae is processed) 12g, Semen Ziziphi Spinosae (stir-fry) 16g, Fructus Quisqualis 16g, Radix Scutellariae 12g, twice of Radix Glycyrrhizae 8g extracting in water, amount of water is 10 times, 8 times of amounts, extraction time is 3 hours, 2 hours, collect volatile oil during extraction simultaneously, volatile oil is standby; Merge extractive liquid, filters, and filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), puts cold, add ethanol and make and contain alcohol amount and reach 70%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50 ℃ of surveys), drying, the water extracting alcohol hypostasis.
The thick paste of getting behind ethanol extraction thick paste and the water extract-alcohol precipitation adds starch 40g and former medicated powder mixing, granulate drying, granulate, getting volatile oil adds dehydrated alcohol and fully dissolves, spray in the above-mentioned granule, seal 24 hours, add 3.0g magnesium stearate mixing, fill, make 1000 (0.30g/ grains), packing, promptly.
Embodiment 2:
The preparation of the precious gold plaque of woman:
(1) get Poria 16g, Colla Corii Asini (Pulvis concha Mactrae scalds) 24g, charred Cortex Eucommiae 24g, Endoconcha Sepiae 16g, Concha Ostreae (forging) 8g, dried Alumen 16g, Cortex Moutan 8g, charred Folium Artemisiae Argyi 16g, Semen Nelumbinis (removing the heart) 60g are ground into fine powder, and be standby.
(2) get Radix Angelicae Sinensis 40g, Rhizoma Chuanxiong 16g, Radix Paeoniae Alba 40g Herba Leonuri 16g, Fructus Evodiae (Radix Glycyrrhizae is processed) 20g, Rhizoma Ligustici 20g, Rhizoma Corydalis (processed with vinegar) 16g, Rhizoma Picrorhizae 8g, Rhizoma Coptidis 8g add 85% ethanol and carry out reflux, extract, twice, the alcohol solvent consumption is 7 times of amounts, 5 times of amounts, and reflux extracting time is 2.0 hours, 1.5 hours.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with medicinal residues behind the above ethanol extraction and remaining Semen Nelumbinis 100g and Radix Rehmanniae 16g, Radix Rehmanniae Preparata 16g, the Radix Astragali (processed with honey) 16g, Radix Codonopsis 48g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 40g, Rhizoma Atractylodis 12g, Radix Polygoni Multiflori (black soya bean wine is processed) 16g, Fructus Psoraleae (salt is processed) 16g, Ramulus Cinnamomi 4g, Fructus Alpiniae Oxyphyllae (salt is processed) 16g, Halloysitum Rubrum (forging quench in vinegar) 10g, Fructus Cnidii 24g, Cortex Ailanthi (parched with bran) 16g, MUZHUA 16g, Radix Clematidis 16g, Radix Gentianae Macrophyllae 22g, Rhizoma Et Radix Notopterygii 8g, Radix Angelicae Pubescentis 8g, Radix Angelicae Dahuricae 8g, Radix Dipsaci 16g, Radix Cyathulae 8g, Radix Bupleuri 40g, Radix Curcumae 16g, Rhizoma Cyperi (processed with vinegar) 32g, Fructus Amomi Rotundus core 1.6g, Fructus Amomi 1.6g, Exocarpium Citri Grandis 8g, Pericarpium Citri Reticulatae Viride (process with vinegar) 12g, Rhizoma Pinelliae Preparatum 12g, Rhizoma Acori Graminei 72g, Radix Polygalae (coring, Radix Glycyrrhizae is processed) 12g, Semen Ziziphi Spinosae (stir-fry) 16g, Fructus Quisqualis 16g, Radix Scutellariae 12g, twice of Radix Glycyrrhizae 8g extracting in water, amount of water is 10 times, 8 times of amounts, extraction time is 3 hours, 2 hours, collect volatile oil during extraction simultaneously, volatile oil is standby; Merge extractive liquid, filters, and filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), puts cold, add ethanol and make and contain alcohol amount and reach 70%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50 ℃ of surveys), drying, the water extracting alcohol hypostasis.
The thick paste of getting behind ethanol extraction thick paste and the water extract-alcohol precipitation adds microcrystalline Cellulose 40g and former medicated powder mixing, granulates drying, granulate, get volatile oil and add dehydrated alcohol and fully dissolve, spray in the above-mentioned granule, seal 24 hours, add 2.0g magnesium stearate mixing, fill is made 1000 (0.30g/ sheets), coating, packing, promptly.
Claims (7)
1, the gynopathic Chinese medicine preparation of a kind of treatment, it is characterized in that per 1000 dosage units are made by the following weight proportion raw material: 20～80 parts of Radix Angelicae Sinensis, 8～32 parts of Rhizoma Chuanxiongs, 20～80 parts of the Radix Paeoniae Albas, 8～32 parts of Radix Rehmanniae, 8～32 parts of Radix Rehmanniae Preparata, 8～32 parts of Herba Leonuris, 8～32 parts of the Radixs Astragali (processed with honey), 24～96 parts of Radix Codonopsis, 20～80 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 6～24 parts of Rhizoma Atractylodis, 8～32 parts in Poria, 12～48 parts in Colla Corii Asini (Pulvis concha Mactrae scalds), 8～32 parts of Radix Polygoni Multiflori (black soya bean wine is processed), 8～32 parts of Fructus Psoraleaes (salt is processed), 2～8 parts of Ramulus Cinnamomi, 8～32 parts of Fructus Alpiniae Oxyphyllae (salt is processed), 10～40 parts of Fructus Evodiaes (Radix Glycyrrhizae is processed), 5～20 parts of Halloysitum Rubrums (forging quench in vinegar), 12～48 parts of charred Cortex Eucommiaes, 8～32 parts of Endoconcha Sepiaes, 4～16 parts of Concha Ostreaes (forging), 12～48 parts of Fructus Cnidiis, 8～32 parts of dried Alumens, 8～32 parts of Cortex Ailanthis (parched with bran), 8～32 parts of MUZHUA, 8～32 parts of Radix Clematidis, 11～44 parts of Radix Gentianae Macrophyllae, 4～16 parts of Rhizoma Et Radix Notopterygiis, 4～16 parts of Radix Angelicae Pubescentiss, 4～16 parts of the Radixs Angelicae Dahuricae, 10～40 parts of Rhizoma Ligusticis, 8～32 parts of Radix Dipsacis, 4～16 parts of Radix Cyathulaes, 20～80 parts of Radix Bupleuri, 8～32 parts of Rhizoma Corydalis (processed with vinegar), 8～32 parts of Radix Curcumaes, 16～64 parts of Rhizoma Cyperis (processed with vinegar), 4～16 parts of Cortex Moutans, 1～4 part of Fructus Amomi Rotundus core, 1～4 part of Fructus Amomi, 4～16 parts of Exocarpium Citri Grandises, 6～24 parts of Pericarpium Citri Reticulatae Viride (process with vinegar), 6～24 parts of Rhizoma Pinelliae Preparatum, 8～32 parts of charred Folium Artemisiae Argyis, 36～144 parts of Rhizoma Acori Graminei, 6～24 parts of Radix Polygalaes (coring, Radix Glycyrrhizae is processed), 8～32 parts of Semen Ziziphi Spinosaes (stir-fry), 8～32 parts of Fructus Quisqualis, 4～32 parts of Rhizoma Picrorhizae, 4～32 parts of Rhizoma Coptidis, 6～24 parts of Radix Scutellariaes, 80～320 parts in Semen Nelumbinis (removing the heart), 4～16 parts in Radix Glycyrrhizae.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
40 parts of Radix Angelicae Sinensis, 16 parts of Rhizoma Chuanxiongs, 40 parts of the Radix Paeoniae Albas, 16 parts of Radix Rehmanniae, 16 parts of Radix Rehmanniae Preparata, 16 parts of Herba Leonuris, 16 parts of the Radixs Astragali (processed with honey), 48 parts of Radix Codonopsis, 40 parts of the Rhizoma Atractylodis Macrocephalaes (parched with bran), 12 parts of Rhizoma Atractylodis, 16 parts in Poria, 24 parts in Colla Corii Asini (Pulvis concha Mactrae scalds), 16 parts of Radix Polygoni Multiflori (black soya bean wine is processed), 16 parts of Fructus Psoraleaes (salt is processed), 4 parts of Ramulus Cinnamomi, 16 parts of Fructus Alpiniae Oxyphyllae (salt is processed), 20 parts of Fructus Evodiaes (Radix Glycyrrhizae is processed), 10 parts of Halloysitum Rubrums (forging quench in vinegar), 24 parts of charred Cortex Eucommiaes, 16 parts of Endoconcha Sepiaes, 8 parts of Concha Ostreaes (forging), 24 parts of Fructus Cnidiis, 16 parts of dried Alumens, 16 parts of Cortex Ailanthis (parched with bran), 16 parts of MUZHUA, 16 parts of Radix Clematidis, 22 parts of Radix Gentianae Macrophyllae, 8 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Radix Angelicae Pubescentiss, 8 parts of the Radixs Angelicae Dahuricae, 20 parts of Rhizoma Ligusticis, 16 parts of Radix Dipsacis, 8 parts of Radix Cyathulaes, 40 parts of Radix Bupleuri, 16 parts of Rhizoma Corydalis (processed with vinegar), 16 parts of Radix Curcumaes, 32 parts of Rhizoma Cyperis (processed with vinegar), 8 parts of Cortex Moutans, 1.6 parts of Fructus Amomi Rotundus cores, 1.6 parts of Fructus Amomis, 8 parts of Exocarpium Citri Grandises, 12 parts of Pericarpium Citri Reticulatae Viride (process with vinegar), 12 parts of Rhizoma Pinelliae Preparatum, 16 parts of charred Folium Artemisiae Argyis, 72 parts of Rhizoma Acori Graminei, 12 parts of Radix Polygalaes (coring, Radix Glycyrrhizae is processed), 16 parts of Semen Ziziphi Spinosaes (stir-fry), 16 parts of Fructus Quisqualis, 8 parts of Rhizoma Picrorhizae, 8 parts of Rhizoma Coptidis, 12 parts of Radix Scutellariaes, 160 parts in Semen Nelumbinis (removing the heart), 8 parts in Radix Glycyrrhizae.
3, claim 1 or any one Chinese medicine preparation of 2 are granule, chewable tablet, tablet, effervescent tablet, effervescent granule.
4, the Chinese medicine preparation of claim 4 is characterized in that, described extraction process prepares through following steps:
(1) Semen Nelumbinis powder of getting Poria, Colla Corii Asini (Pulvis concha Mactrae scalds), charred Cortex Eucommiae, Endoconcha Sepiae, Concha Ostreae (forging), dried Alumen, Cortex Moutan, charred Folium Artemisiae Argyi and 60 parts is broken into fine powder, and is standby.
(2) getting Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Herba Leonuri, Fructus Evodiae (Radix Glycyrrhizae is processed), Rhizoma Ligustici, Rhizoma Corydalis (processed with vinegar), Rhizoma Picrorhizae, Rhizoma Coptidis adds ethanol and carries out reflux, extract, twice, the alcohol solvent consumption is 4～10 times of medical material amount, concentration of alcohol is 50～90%, return time 0.5～2.0 hour.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with medicinal residues behind the above ethanol extraction and remaining Semen Nelumbinis and Radix Rehmanniae, Radix Rehmanniae Preparata, the Radix Astragali (processed with honey), Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae (parched with bran), Rhizoma Atractylodis, Radix Polygoni Multiflori (black soya bean wine is processed), Fructus Psoraleae (salt is processed), Ramulus Cinnamomi, Fructus Alpiniae Oxyphyllae (salt is processed), Halloysitum Rubrum (forging quench in vinegar), Fructus Cnidii, Cortex Ailanthi (parched with bran), MUZHUA, Radix Clematidis, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix Dipsaci, Radix Cyathulae, Radix Bupleuri, Radix Curcumae, Rhizoma Cyperi (processed with vinegar), Fructus Amomi Rotundus core, Fructus Amomi, Exocarpium Citri Grandis, Pericarpium Citri Reticulatae Viride (process with vinegar), Rhizoma Pinelliae Preparatum, Rhizoma Acori Graminei, Radix Polygalae (coring, Radix Glycyrrhizae is processed), Semen Ziziphi Spinosae (stir-fry), Fructus Quisqualis, Radix Scutellariae, twice of Radix Glycyrrhizae extracting in water, amount of water is 4～10 times, each extraction time is 0.5～3 hour, collect volatile oil during extraction simultaneously, volatile oil is standby; Merge extractive liquid,, filter, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 8～48 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, the water extracting alcohol hypostasis.
5, the Chinese medicine preparation of claim 3, through described raw material is extracted processing, obtain each extract part, add suitable adjuvant as required and make, ethanol extraction, water extract and volatile oil lump together the active constituents of medicine into preparation of the present invention.
6, the Chinese medicine preparation of claim 3 is characterized in that: the preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule; The preparation process of capsule is as follows: with above-mentioned extract obtained, granulate with medicated powder, add lubricant and fill, promptly get capsule; The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
7, the Chinese medicine preparation of claim 6 is characterized in that: described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.; Described correctives one of is selected from water Fructus Citri sinensis powdered flavor, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, stevioside, Mentholum, the Oleum menthae or wherein several mixture; Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
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| CNA2006100728461A CN1857690A (en) | 2006-04-11 | 2006-04-11 | Gynecopathy treating preparation and its preparing process |
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