CN1931336A - Chinese medicine composition and its prepn process - Google Patents
Chinese medicine composition and its prepn process Download PDFInfo
- Publication number
- CN1931336A CN1931336A CN 200610159783 CN200610159783A CN1931336A CN 1931336 A CN1931336 A CN 1931336A CN 200610159783 CN200610159783 CN 200610159783 CN 200610159783 A CN200610159783 A CN 200610159783A CN 1931336 A CN1931336 A CN 1931336A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- weight portions
- medicine composition
- thick paste
- schisandrae chinensis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The present invention discloses one kind of Chinese medicine composition prepared with ginseng, ophiopogon root, schisandra, coix seed and other Chinese medicine materials. The Chinese medicine composition is used for the subsidiary treatment of radiation caused chronic qi and yin deficiency and leucopenia clinically. The present invention also discloses the preparation process of the Chinese medicine composition.
Description
Invention field
The present invention relates to the preparation method of a kind of Chinese medicine composition and said composition, particularly a kind of syndrome of deficiency of both qi and yin that chronic radiation causes and Chinese medicine composition of leukopenia patients and preparation method thereof of being used for.
Background technology
Malignant tumor is the commonly encountered diseases and the frequently-occurring disease of serious threat human health, and according to World Health Organization's report, in more than 50 hundred million populations of the whole world, the tumor patient of annual new diagnosis is about 9,000,000 people, and dead person reaches 7,000,000 people/a because of tumor, accounts for nearly 20% of total case fatality rate.Drug therapy occupies an important position in three big therapies of malignant tumor, and is with the fastest developing speed.The overwhelming majority is a lead compound with the natural anti-cancer active component in synthetic chemical classes cancer therapy drug, and the exploitation of cancer therapy drug comprises that computer mould fits Bionic Design all based on the natural anti-cancer active component.There is abundant resources of medicinal plant in China, the medical expert of China uses the experience of natural anti-cancer drugs according to various nationalities since the sixties, from national medicine, researched and developed out a collection of alleviate put, the natural drug of untoward reaction that chemotherapy causes, the cancer patient who is used for the auxiliary treatment syndrome of blood stasis due to qi deficiency is for due contribution has been made in the control of cancer.
In the oncotherapy, adopting tonification class Chinese medicine to carry out the body resistance strengthening and constitution consolidating is one of advantage of Chinese medicine tumor, wider to its research in recent years.Motherland's medical science thinks, tumor is many take advantage of a weak point by the weak pathogen of human righteousness due to, modern medicine confirms that human immunity state and tumor generation, development and prognosis are closely related, the theory of Chinese medicine deficiency-syndrome and modern immunologic hypofunction matches.Use tonification class Chinese medicine the body resistance strengthening and constitution consolidating, can improve the tumor patient function, from the growth of molecular level regulation and control cancerous cell, and can the direct killing cancerous cell, so use that tonification class Chinese medicine encourages healthy trends, vital base and primordial QI consolidating has its theoretical foundation as one of method of treatment tumor.
Tonic is that the main prescription of setting upright is widely used in clinical tumor, act as: treatment precancerous lesion, and prophylaxis of tumours takes place; Cooperate operation, chemicotherapy, play potentiation; The prophylaxis of tumours relapse and metastasis; Alleviate the chemicotherapy toxicity; Treatment middle and advanced stage tumor is improved symptom, improves life quality, is prolonged band tumor life span.In oncotherapy, the rational Application traditional tonic medicine can play potentiation, QI invigorating, nourish blood, YIN nourishing, medicine such as supporing yang be in the tumor of different parts, and different stressing arranged during application.The chemotherapy of tumors patient is in Chinese medical discrimination, type of deficiency of both QI and YIN is much, on Chinese medicine is selected, be main formula, as SHENGMAI YIN (Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis), MAIWEIDIHUANGWAN (Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Cortex Moutan, Poria, Rhizoma Alismatis, Radix Ophiopogonis, Fructus Schisandrae Chinensis) etc. with Qi-tonifying drug in the tonic and YIN-tonifying drug.
A large amount of clinical practice explanation, the determined curative effect of tonification class Chinese medicine in oncotherapy, especially at mitigation symptoms, improve aspect the life quality, irreplaceable effects such as chemotherapy are arranged.Therefore, performance Chinese medicine advantage is excavated the new problem that the effective cancer therapy drug of exploitation becomes current traditional Chinese medical science development, and effective component extracting is made corresponding dosage form, and it is an aspect of present Chinese medicine exploitation that expansion is promoted.As at present clinical the KANGLAITE that presses down the tumor effect is arranged, the SHENMAI ZHUSHEYE of bone marrow protective effect is arranged, the use of representative in clinical as tonic is subjected to doctor and patient's approval.Prevent and treat precancerous lesion, the prophylaxis of tumours relapse and metastasis is an emphasis of current Chinese medicine tumor research.Tonification apoplexy due to endogenous wind medical instrument has immunostimulant, tumor-inhibiting action, will hew out gratifying prospect for its extensive use in this field undoubtedly.
Summary of the invention
One object of the present invention is to provide a kind of boosting qi and nourishing yin effect that has; Be used for the syndrome of deficiency of both qi and yin that chronic radiation causes and the Chinese medicine composition of leukopenia patients.
The object of the present invention is achieved like this, according to the Chinese medicine and pharmacy theory, utilizes the property of medicine of medical herbs uniqueness, and the crude drug composition and the proportioning of the preparation present composition are as follows:
Radix Ginseng 100~150 weight portions, Radix Ophiopogonis 280~320 weight portion, Fructus Schisandrae Chinensis 300~350 weight portions, Semen Coicis 220~280 weight portions.
The crude drug of the present composition is formed best proportioning:
Radix Ginseng 125 weight portions, Radix Ophiopogonis 300 weight portion, Fructus Schisandrae Chinensis 325 weight portions, Semen Coicis 250 weight portions.
Clinical use for convenience, the inventor has done further research at this crude drug, to formulate its extraction and preparation technique, is made into various dosage forms clinical or that pharmacy is required, as capsule, tablet, pill, etc.The technical study process is as follows:
Get Radix Ophiopogonis, Fructus Schisandrae Chinensis two flavor is ground into coarse powder, adds 65% alcohol reflux twice, adds 5 times of amounts for the first time, extracted 2 hours, and added 4 times of amounts for the second time, extracted merge extractive liquid, 1 hour, filter, reclaim ethanol, relative density is 1.25~1.30 thick paste when being concentrated into 50 ℃; The heart of a lotus seed is broken into fine powder like core, Radix Ginseng powder, merges with thick paste, stirs, and drying adds suitable adjuvant, makes required dosage form.
Further verify this prescription compositions at boosting qi and nourishing yin by in-vitro pharmacological experiments, to the influence of S180 tumor-bearing mice (RES) reticuloendothelial system phagocytic function:
Medicine and reagent:
Be subjected to the reagent thing: the present composition; Specification: 2g crude drug/1ml solution; Positive drug: sunrecome;
Specification: every packed 2 grams;
Animal:
The ICR white mice, 18~22g, male and female half and half are provided by animal housing of China Medicine University;
Tumor strain source:
S180 is provided by Jiangsu Province's tumour medicine institute.
Method:
Get 50 of above-mentioned specification ICR mices, press transplanted tumor organon inoculation S180 solid type tumor, inoculate back 24 hours and claim Mus heavy, be divided into 5 groups at random by body weight, 10 every group.If matched group (0.5%CMC-Na, 0.2ml/10g), sunrecome group (1000mg/kg), the high, medium and low dosage group of the administration group present composition (1000,600,300mg/kg).Inoculate ig administration after 24 hours, once a day, administration is 10 times altogether, 1h after the last administration, tail vein injection india ink (dilution in 1: 3) 0.05ml/10g, after injecting ink, get blood 20 μ l with quantitative blood taking tube from the mouse orbit rear vein beard when 1 minute and 5 minutes, be blown at once among the 0.1%Na2CO3 liquid 2ml, colorimetric records optical density (OD1 in the 680nm place, OD5), after the 5min blood sampling, put to death mice immediately, weigh, and get liver, spleen is weighed, be calculated as follows phagocytic index K and engulf the factor alpha value.The gained data are carried out statistical procedures (t check).
Phagocytic index K=LogOD1 ÷ OD5 ÷ 4
The heavy ÷ body weight of index and spleen index=spleen
Result of the test:
This compositions to the influence of S180 tumor-bearing mice (RES) reticuloendothelial system phagocytic function (X ± S, n=10)
Group | Dosage (mg/kg) | Phagocytic index k * 10-1 | Engulf factor alpha | Index and spleen index (g/kg) |
This compositions of blank group sunrecome | 1000 600 300 1000 | 0.39±0.12 0.61±0.13** 0.56±0.13** 0.50±0.16 0.58±0.14** | 5.49±0.48 6.00±0.55* 5.93±0.66 5.74±0.72 5.98±0.46* | 14.12±2.86 17.63±1.68** 17.55±3.24* 17.89±6.97 17.26±3.20* |
Above result of the test shows that this Chinese medicine composition compares with the blank group, can obviously strengthen tumor-bearing mice reticuloendothelial system phagocytic function, and is suitable with the effect of positive drug sunrecome.
The specific embodiment
Illustrate with specific embodiment more below, to the present invention without limits but following embodiment only is used to the present invention is described.
Embodiment 1:
Prescription: Radix Ginseng 125g 300g Radix Ophiopogonis Fructus Schisandrae Chinensis 325g Semen Coicis 250g
Method for making: above four flavors, except that Semen Coicis, Radix Ginseng, Radix Ophiopogonis etc. two, flavor was ground into coarse powder, added twice of 65% alcohol reflux, add for the first time 5 times of amounts, extracted 2 hours, and added 4 times of amounts for the second time, extracted 1 hour, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is the thick paste of 1.25~1.30 (50 ℃); The heart of a lotus seed is broken into fine powder like core, Radix Ginseng powder, merges with thick paste, stirs, and drying is ground into fine powder, incapsulates, and makes 1000, promptly.
Embodiment 2:
Prescription: Radix Ginseng 100g 280g Radix Ophiopogonis Fructus Schisandrae Chinensis 300g Semen Coicis 220g
Method for making: above four flavors, except that Semen Coicis, Radix Ginseng, Radix Ophiopogonis etc. two, flavor was ground into coarse powder, added twice of 65% alcohol reflux, add for the first time 5 times of amounts, extracted 2 hours, and added 4 times of amounts for the second time, extracted 1 hour, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is the thick paste of 1.25~1.30 (50 ℃); The heart of a lotus seed is broken into fine powder like core, Radix Ginseng powder, merges with thick paste, stirs, and granulates, and drying is pressed into 1000, promptly.
Embodiment 3:
Prescription: Radix Ginseng 300g 640g Radix Ophiopogonis Fructus Schisandrae Chinensis 700g Semen Coicis 560g
Method for making: above four flavors, except that Semen Coicis, Radix Ginseng, Radix Ophiopogonis etc. two, flavor was ground into coarse powder, added twice of 65% alcohol reflux, add for the first time 5 times of amounts, extracted 2 hours, and added 4 times of amounts for the second time, extracted 1 hour, merge extractive liquid,, filter, reclaim ethanol, being concentrated into relative density is the thick paste of 1.25~1.30 (50 ℃); The heart of a lotus seed is broken into fine powder like core, Radix Ginseng powder, merges with thick paste, stirs, and drying is ground into fine powder, add carboxymethylstach sodium 20g, microcrystalline Cellulose 100g, and add starch to total amount 1000g, mix homogeneously is an adhesive system soft material with water, be pressed into ball, drying, packing, promptly.
Claims (6)
1, a kind of pharmaceutical composition is characterized in that said composition made by following medicine:
Radix Ginseng 100~150 weight portions
Radix Ophiopogonis 280~320 weight portion
Fructus Schisandrae Chinensis 300~350 weight portions
Semen Coicis 220~280 weight portions.
2, pharmaceutical composition according to claim 1 is characterized in that said composition made by following medicine:
Radix Ginseng 125 weight portions
Radix Ophiopogonis 300 weight portion
Fructus Schisandrae Chinensis 325 weight portions
Semen Coicis 250 weight portions.
3, Chinese medicine composition according to claim 1 and 2 is characterized in that the dosage form that can make at last is a kind of in capsule, tablet, the pill common formulations.
4,, it is characterized in that comprising following technical process according to the preparation method of the described Chinese medicine composition of claim 3:
Get Radix Ophiopogonis, Fructus Schisandrae Chinensis two flavor is suitably pulverized, and adds 60~70% alcohol reflux 1~3 time, extracts 1~2 hour at every turn, and merge extractive liquid, filters, and reclaims ethanol, is concentrated into relative density and is 1.25~1.30 thick paste; The heart of a lotus seed is broken into fine powder like core, Radix Ginseng powder, merges with thick paste, stirs, and drying adds conventional adjuvant, makes required dosage form.
5, the preparation method of Chinese medicine composition according to claim 4, its detailed features is:
Get Radix Ophiopogonis, Fructus Schisandrae Chinensis two flavor is ground into coarse powder, adds 65% alcohol reflux twice, adds 5 times of amounts for the first time, extracted 2 hours, and added 4 times of amounts for the second time, extracted merge extractive liquid, 1 hour, filter, reclaim ethanol, relative density is 1.25~1.30 thick paste when being concentrated into 50 ℃; The heart of a lotus seed is broken into fine powder like core, Radix Ginseng powder, merges with thick paste, stirs drying; Add suitable adjuvant, make required dosage form.
6, Chinese medicine composition according to claim 1 and 2 is used for the treatment of syndrome of deficiency of both qi and yin that chronic radiation causes and the application in the leukopenia medicine in preparation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2006101597833A CN1931336B (en) | 2005-10-08 | 2006-10-08 | Chinese medicine composition and its preparation process |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200510107865 | 2005-10-08 | ||
CN200510107865.9 | 2005-10-08 | ||
CN2006101597833A CN1931336B (en) | 2005-10-08 | 2006-10-08 | Chinese medicine composition and its preparation process |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1931336A true CN1931336A (en) | 2007-03-21 |
CN1931336B CN1931336B (en) | 2011-06-08 |
Family
ID=37877461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006101597833A Expired - Fee Related CN1931336B (en) | 2005-10-08 | 2006-10-08 | Chinese medicine composition and its preparation process |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1931336B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102085318B (en) * | 2009-12-08 | 2012-06-27 | 西安兆兴制药有限公司 | Coix seed/ginseng buccal tablet and preparation method thereof |
US20150290275A1 (en) * | 2012-05-29 | 2015-10-15 | Jiangzhong Pharmaceutical Co., Ltd. | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
CN108465042A (en) * | 2017-05-03 | 2018-08-31 | 成都中医药大学 | It is a kind of can room temperature storage Radix Ophiopogonis particle and preparation method thereof |
-
2006
- 2006-10-08 CN CN2006101597833A patent/CN1931336B/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102085318B (en) * | 2009-12-08 | 2012-06-27 | 西安兆兴制药有限公司 | Coix seed/ginseng buccal tablet and preparation method thereof |
US20150290275A1 (en) * | 2012-05-29 | 2015-10-15 | Jiangzhong Pharmaceutical Co., Ltd. | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
US9744203B2 (en) * | 2012-05-29 | 2017-08-29 | Jiangzhong Pharmaceutical Co., Ltd. | Application of composition in preparing health care product or medicine for preventing and treating leukopenia caused by radiotherapy and chemotherapy |
CN108465042A (en) * | 2017-05-03 | 2018-08-31 | 成都中医药大学 | It is a kind of can room temperature storage Radix Ophiopogonis particle and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN1931336B (en) | 2011-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103007052A (en) | Compound dendrobium extract composition capable of delaying senility | |
CN103550506B (en) | A kind of in radiotherapy with the use of Chinese medicine composition | |
CN102119970A (en) | Chinese medicinal composition for treating myasthenia gravis | |
CN101091769B (en) | Medicine for treating and preventing esophagus cancer and gastric cancer, and preparation method | |
CN1931336B (en) | Chinese medicine composition and its preparation process | |
CN102631526B (en) | Chinese medicinal composition for treating diabetes mellitus | |
CN102861193A (en) | Traditional Chinese medicine composition for treating gastric cancer | |
CN1596970A (en) | Traditional Chinese medicament for treating woman subhealthy faligue syndrome and its preparation method | |
CN110934924A (en) | Traditional Chinese medicine bone marrow hematogenesis composition and application thereof | |
CN1943607B (en) | Chinese medicine composition for nourishing qi and yin and its preparing method | |
CN101947261A (en) | Method for preparing traditional Chinese medicinal composition for postoperative recovery in concurrent chemoradiotherapy | |
CN1513497A (en) | Immunity regulation medicine composition, and its prepn. method | |
CN1943661B (en) | A Chinese traditional medicinal composition and its preparation method | |
CN1931352A (en) | Chinese medicine composition and its prepn process | |
CN101675961B (en) | A medicinal preparation for treating breast cancer and preparation method thereof | |
CN1931285B (en) | Chinese medicine composition and its preparation process | |
CN1150934C (en) | Qizhen capsule and its preparing process | |
CN1836702A (en) | Medicine for treating tumour and its preparing method | |
CN1042495C (en) | Medicine for benefitting Qi, removing cancer and raising leucocyte and its prepn. | |
CN1269518C (en) | Compound medicine for treating tuberculosis and its preparing method | |
CN100502912C (en) | Medicine for treating deficiency syndrome, its preparing process and usage | |
CN1850236A (en) | Method for preparing medicine for treating malignancy disease and use thereof | |
CN103055036A (en) | Method for preparing medicament for treating leucopenia | |
CN1943677A (en) | A Chinese traditional medicinal composition and its preparation method | |
CN1256083C (en) | Medicine for boosting qi and nourishing blood and its prepatation method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110608 Termination date: 20151008 |
|
EXPY | Termination of patent right or utility model |