CN1269518C - Compound medicine for treating tuberculosis and its preparing method - Google Patents

Compound medicine for treating tuberculosis and its preparing method Download PDF

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CN1269518C
CN1269518C CN 200410060657 CN200410060657A CN1269518C CN 1269518 C CN1269518 C CN 1269518C CN 200410060657 CN200410060657 CN 200410060657 CN 200410060657 A CN200410060657 A CN 200410060657A CN 1269518 C CN1269518 C CN 1269518C
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extract
tuberculosis
medicine
radix
flos
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CN1586526A (en
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邢乐道
黄硕彦
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邢乐道
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Abstract

The present invention relates to compound medicine for curing tuberculosis and a preparation method thereof, particularly to potent traditional Chinese medicine compound medicine for curing tuberculosis, such as various tuberculosis caused by tubercle bacilli, especially intractable tuberculosis and medicine tolerance tuberculosis, a preparation method thereof and an application method thereof. The compound medicine for curing tuberculosis is prepared by pulverizing and mixing stemonae extract, fewflower lysionotus herb extract, lupulus extract, pagodatree flower bud extract, artemisia apiacea extract, yew extract, fleeceflower root extract, blackend swallowwort root extract, rhizoma polygonati extract, apricot kernel extract, oriental arborvitae extract, Chinese usnea extract, metaplexis extract, etc. The compound medicine for curing tuberculosis has no toxic or side effect, is easy to accept by patients, has no harm action on the functions, the tissues and the viscera of human bodies, is convenient to take, and rapidly takes effects. The compound medicine can ensure that tubercle bacilli in human bodies can be effectively eliminated and completely and thoroughly cure tuberculosis, and has the advantages of accurate curative effect, short cure period, no medicine tolerance or medicine resistance. Valuable traditional Chinese medicinal materials do not exist in a prescription, all the components are traditional Chinese medicine crude extracts, technologies are simple, and price is low.

Description

A kind of treatment compound medicine lungy and preparation method thereof
Technical field the present invention relates to a kind of treatment compound medicine lungy and preparation application process thereof, it comprises treatment by the various tuberculosis that tubercule bacillus causes, and particularly relates to the potent traditional Chinese compound medicine and the preparation application process thereof of intractable tuberculosis and drug-resistant tuberculosis.。
Background technology China is second largest in the world tuberculosis state occurred frequently, and the tuberculosis epidemic situation of China has following: have 5.5 hundred million people to infect tubercule bacillus approximately; Active tuberculosis patient 5,000,000 people are arranged, wherein infectiousness (being coated with sun) pulmonary tuberculosis patient 1,500,000 people; Annual New Development patient is many, according to the estimation of WHO, and annual New Development active tuberculosis patient 1,300,000 examples, wherein infectiousness (being coated with sun) pulmonary tuberculosis patient 580,000 examples; There are every year 130000 people to die from tuberculosis approximately; Drug resistance patient is many, and the tuberculosis resistant rate is up to 27.8%.
More than these data tell people, tuberculosis has surpassed general hygiene and health notion, becomes a complicated social problem that hinders social development, so must effectively treat tuberculosis.
A generation that thorny problem is a drug-resistant tuberculosis in the new epidemic situation of tuberculosis.Just sending out in the tuberculosis patient,, will cause drug-resistant tuberculosis, when drug-resistant tuberculosis develops into anti-two or more anti-tuberculosis drugs, just forming anti-multiple medicines tuberculosis (MDR-TB) as the treatment failure.Anti-multiple medicines tuberculosis is extremely refractory and expensive very big disease, and mortality rate is very high.Prevention and control have proposed severe challenge to tuberculosis for it.
In order to contain the generation that spreads with drug-resistant tuberculosis lungy, since nineteen eighty, clinically some tuberculosis patients have been taked fixed dosage conjoint therapy (FDC), this is a kind of rifampicin, isoniazid and streptomycin, the mode of one line such as pyrazinamide and two wires antitubercular agent administering drug combinations, these medicines are all bigger to the toxic and side effects of human body, to other functions of human body such as liver, kidney has certain detrimental effect, what time unfavorable to the patient clinical main existence is following: the one, and coupling, must be with 3~6 kinds of medication combined application, the patient can not tolerate, and toxicity is big; The 2nd, treatment is long the course of treatment, the therapeutic scheme course of treatment that general patient is difficult to finish regulation; The 3rd, not good enough to therapeutic effect such as tuberculous lymphadenitis, bone tuberculosis, tuberculous peritonitis; The 4th, critically ill patient also need cooperate clearance of focal lesion, and operation is complicated, and 1/5 patient's cisco unity malfunction and study are arranged approximately.
Domestic have the treatment Chinese medicine lungy, as " Chinese medicine " Jiehekang " for treatment of tuberculosis and manufacture method thereof " (number of patent application 94111244.6), it makes pill with prescriptions such as Chinese herbal medicine Radix Ranunculi Ternati, dried shortcake, Herba Artemisiae Annuae, Bulbus Fritillariae Cirrhosaes, give the oral or external application of patient, treatment pulmonary tuberculosis, bone tuberculosis, tuberculosis of joint and even lymph malignant tumor etc. are had significant curative effect." a kind of treatment Chinese medicine lungy " (number of patent application 01106313), by the Radix Astragali, Concha Ostreae, Radix Scrophulariae, Fructus Schisandrae Chinensis, Bulbus Lilii, the Radix Stemonae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Carapax et Plastrum Testudinis, Scolopendra, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Bulbus Fritillariae Cirrhosae, Placenta Hominis, Ramulus Cinnamomi, Cordyceps, Pericarpium Citri Reticulatae are formulated, it has anti-consumptive disease bacterium, nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, sets upright the function of parasite killing, nourishing YIN and moistening the lung." a kind of treatment tuberculosis " (number of patent application 94104024.0), it is formulated by Carapax Trionycis, the Radix Stemonae, dried Gecko, Bombyx Batryticatus etc.
Summary of the invention purpose of the present invention aims to provide and can replace chemotherapeutics, intractable tuberculosis and drug-resistant tuberculosis is effected a radical cure do not recur, a kind of treatment compound medicine lungy that toxic and side effects is little, curative effect is high and preparation method thereof.
The implementation of purpose of the present invention is, a kind of treatment compound medicine lungy is formulated by the composition that weight proportion is following:
Radix Stemonae extract 100~190g Herba Lysionoti Pauciflori extract 100~190g
Flos lupuli (Flos Humuli Lupuli) extract 100~190g Flos Sophorae Immaturus extract 100~190g
Herba Artemisiae Annuae extract 100~190g Ramulus et folium taxi cuspidatae Extract 10~90g
Radix Polygoni Multiflori extract 100~190g Radix Cynanchi Atrati extract 100~190g
Rhizoma Polygonati extract 100~190g Semen Armeniacae Amarum extract 10~90g
Cacumen Platycladi extract 10~90g Usnea extract 100~190g
Herba seu Radix Metaplexis hemsleyanae extract 100~190g.
A kind of preparation method for the treatment of compound medicine lungy, with 100~190g Radix Stemonae extract, 100~190g Herba Lysionoti Pauciflori extract, 100~190g Flos lupuli (Flos Humuli Lupuli) extract, 100~190g Flos Sophorae Immaturus extract, 100~190g Herba Artemisiae Annuae extract, 10~90g Ramulus et folium taxi cuspidatae Extract, 100~190g Radix Polygoni Multiflori extract, 100~190g Radix Cynanchi Atrati extract, 100~190g Rhizoma Polygonati extract, 10~90g Semen Armeniacae Amarum extract, 10~90g Cacumen Platycladi extract, 100~190g Usnea extract, 100~190g Herba seu Radix Metaplexis hemsleyanae extract is ground into fine powder and crosses 100 mesh sieves, adorn in No. 1 capsule, make oral capsule.
The cause of disease lungy is " deficiency of YIN fire is moving ", and the rule of treatment should be " sweet cold yin nourishing ", and YIN nourishing, rescuing YIN, nourishing YIN are when topping the list choosing.It is monarch drug that the present invention mainly adopts the Chinese medicine Ramulus et folium taxi cuspidatae, Ramulus et folium taxi cuspidatae contains taxinine, taxinine A, taxinine H, taxinine K, taxinine L, taxine, taxol, taxusin, 7,4',4'''-Trimethylamentoflavone isoreactivity composition, has the effect of potent anticancer, anti-mycobacterium tuberculosis.Flos lupuli (Flos Humuli Lupuli) contains .beta.-bitter acid, Lupulin composition, has the effect of killing tubercule bacillus, and Herba Lysionoti Pauciflori contains lysionotin, and heat-clearing and toxic substances removing is arranged, hard masses softening and resolving, and relieving cough and resolving phlegm, promoting blood flow to regulate menstruation is mended functions such as lean kidney.Herba Artemisiae Annuae contains arteannuin, and the function of reducing the asthenic fever, removing heat from blood expelling summer-heat, preventing the attack (or recurrence) of malaria is arranged, and this three flavors medicine is a minister; Radix Stemonae nourishing the lung to arrest cough, delousing parasite killing, Cacumen Platycladi, Flos Sophorae Immaturus removing heat from blood, hemostasis, Radix Polygoni Multiflori invigorating the liver and kidney, bone and muscle strengthening, black beard and hair, Radix Cynanchi Atrati contains cynanchol, has clearly asthenic fire, removes heat in blood, moves back the hectic fever due to YIN-deficiency effect, and these five kinds of medicines are assistant; Almond cough-relieving is relievingd asthma, loosening bowel to relieve constipation, Rhizoma Polygonati lung moistening YIN nourishing, invigorating the spleen and replenishing QI.Usnea contains usnic acid, has the effect of killing tubercule bacillus, Herba seu Radix Metaplexis hemsleyanae tonify deficiency labor, and beneficial vital essence, the parasite killing detoxifcation, this four Chinese medicine is for making.Above-mentioned 13 flavor medicine monarch, scientific sanction, ingenious 5 usefulness are played the go out merit of consumptive disease of parasite killing altogether.
This medicine has following advantage:
1, green idea is ideal therapeutic agent with pure treatment by Chinese herbs tuberculosis, and traditional Chinese compound medicine of the present invention then seldom has toxicity, and the patient easily tolerates, and function, tissue, the internal organs of human body are not had any detrimental effect.
2, potent property, the present invention is pure Chinese medicine compound oral formulations, onset is rapid, and the effect mystery can guarantee effectively to kill the intravital tubercule bacillus of people, can effect a radical cure tuberculosis fully, need not operative treatment, never recurrence, short treating period, just can reach clinical cure general two courses of treatment (4 months), and the person of being in a bad way can reach the healing purpose 4 courses of treatment.
3, economy, the present invention is a pure Chinese medicinal preparation, and each composition all is Chinese medicine crude extract (extractum), does not relate to new and high technology, technology is simple, no valuable Chinese crude drug in the prescription, price is low, easy exploiting, it is little that patient's economy is born pressure, is easy to marketing.
Specific embodiment compound medicine of the present invention is mixed through pulverizing by Radix Stemonae extract, Herba Lysionoti Pauciflori extract, Flos lupuli (Flos Humuli Lupuli) extract, Flos Sophorae Immaturus extract, Herba Artemisiae Annuae extract, Ramulus et folium taxi cuspidatae Extract, Radix Polygoni Multiflori extract, Radix Cynanchi Atrati extract, Rhizoma Polygonati extract, Semen Armeniacae Amarum extract, Cacumen Platycladi extract, Usnea extract, Herba seu Radix Metaplexis hemsleyanae extract etc.
Each extract is that percolate reclaims ethanol at low temperatures, the dry extract of lyophilization gained with each flavor medicinal alcohol percolation percolation.
Preparation technology is ground into fine powder with each extract to cross 100 mesh sieves, adorns in No. 1 capsule, makes oral capsule.
Application process: oral each 8 of oral capsule, every day 3 times, taking medicine before meal usefulness, serveing on 2 months is a course of treatment.Can the continuous a plurality of medications course of treatment up to recovering.Child's consumption is half of adult's consumption, and 1 month is a course of treatment.
Enumerate embodiments of the invention below:
Example 1, get the 100g Radix Stemonae extract, the 100g Herba Lysionoti Pauciflori extract, the 100g Flos lupuli (Flos Humuli Lupuli) extract, 100g Flos Sophorae Immaturus extract, the 100g Herba Artemisiae Annuae extract, the 10g Ramulus et folium taxi cuspidatae Extract, the 100g Radix Polygoni Multiflori extract, the 100g Radix Cynanchi Atrati extract, the 100g Rhizoma Polygonati extract, 10g Semen Armeniacae Amarum extract, the 10g Cacumen Platycladi extract, 100g Usnea extract, the 100g Herba seu Radix Metaplexis hemsleyanae extract, press the alcohol percolation method preparation respectively, with the percolate decompression recycling ethanol, lyophilization becomes dry extract, mix then, be ground into fine powder, cross 100 mesh sieves, the enteric coated capsule of packing into No. 1, every 0.5g, use the Brown Glass Brown glass bottles and jars only splendid attire, irradiation sterilization.
Example 2, get 120g Radix Stemonae extract, 120g Herba Lysionoti Pauciflori extract, 120g Flos lupuli (Flos Humuli Lupuli) extract, 120g Flos Sophorae Immaturus extract, 120g Herba Artemisiae Annuae extract, 30g Ramulus et folium taxi cuspidatae Extract, 120g Radix Polygoni Multiflori extract, 120g Radix Cynanchi Atrati extract, 120g Rhizoma Polygonati extract, 30g Semen Armeniacae Amarum extract, 30g Cacumen Platycladi extract, 120g Usnea extract, 120g Herba seu Radix Metaplexis hemsleyanae extract, prepare oral capsule by the method for example 1.
Example 3, get 140g Radix Stemonae extract, 140g Herba Lysionoti Pauciflori extract, 140g Flos lupuli (Flos Humuli Lupuli) extract, 140g Flos Sophorae Immaturus extract, 140g Herba Artemisiae Annuae extract, 50g Ramulus et folium taxi cuspidatae Extract, 140g Radix Polygoni Multiflori extract, 140g Radix Cynanchi Atrati extract, 140g Rhizoma Polygonati extract, 50g Semen Armeniacae Amarum extract, 50g Cacumen Platycladi extract, 140g Usnea extract, 140g Herba seu Radix Metaplexis hemsleyanae extract, prepare oral capsule by the method for example 1.
Example 4, get 160g Radix Stemonae extract, 160g Herba Lysionoti Pauciflori extract, 160g Flos lupuli (Flos Humuli Lupuli) extract, 160g Flos Sophorae Immaturus extract, 160g Herba Artemisiae Annuae extract, 70g Ramulus et folium taxi cuspidatae Extract, 160g Radix Polygoni Multiflori extract, 160g Radix Cynanchi Atrati extract, 160g Rhizoma Polygonati extract, 70g Semen Armeniacae Amarum extract, 70g Cacumen Platycladi extract, 160g Usnea extract, 160g Herba seu Radix Metaplexis hemsleyanae extract, prepare oral capsule by the method for example 1.
Example 5, get 190g Radix Stemonae extract, 190g Herba Lysionoti Pauciflori extract, 190g Flos lupuli (Flos Humuli Lupuli) extract, 190g Flos Sophorae Immaturus extract, 190g Herba Artemisiae Annuae extract, 90g Ramulus et folium taxi cuspidatae Extract, 190g Radix Polygoni Multiflori extract, 190g Radix Cynanchi Atrati extract, 190g Rhizoma Polygonati extract, 90g Semen Armeniacae Amarum extract, 90g Cacumen Platycladi extract, 190g Usnea extract, 190g Herba seu Radix Metaplexis hemsleyanae extract, prepare oral capsule by the method for example 1.
Hubei Prov. Inst. of Traditional Chinese Medicine study of tcm new drug development centre has been done the bacteriostatic test of human body in conjunction with bacillus this medicine, and conclusion is as follows: during the drug level of compound medicine in culture medium≤1.85mg/ml, in conjunction with bacillus H37 bacteriostasis being arranged.
Done acute toxicity test, conclusion is that to the SPF level Kunming mouse filling stomach of two kinds of sexes, once irritating the stomach amount is 68ml/kg.bw (this dosage is equivalent to referrer's 51 times with dosage (crude drug amount 1560g/60kg)), animal does not have obvious poisoning symptom, no animal dead in two weeks.Show that the safety of this medicine under recommended dose is better.
The People's Hospital, Tuanfeng County, Hubei Province has done clinical trial with oral capsule to 100 routine patients.100 routine patients control the patient again through chemotherapeutics therapeutic effect such as isoniazid, rifampicin, pyrazinamide are unfavorable, hectic person 68 examples wherein, its mild or moderate 6 examples, moderate 14 examples, severe 48 examples; Tuberculosis of spine person 16 examples, its mild or moderate 4 examples, moderate 10 examples, severe 2 examples; Meningeal tuberculosis person 4 examples, moderate 1 example wherein, severe 3 examples; Tuberculous lymphadenitis patient's 12 examples, moderate 4 examples wherein, severe 8 examples.
The treatment standard:
Cure: absorb through the complete calcification of focus in 3~6 months, recover normal;
Effectively: took medicine 1 month, focus obviously changes;
Invalid: no change before and after the treatment.
Therapeutic Method; Each 8 of internal diabetes health-care capsule, every day 3 times, ante cibum is oral, and 2 months was 1 course of treatment, treated 1~3 course of treatment, and child's consumption is the adult's 1/2.
Therapeutic outcome is as follows:
Sick class diagnostic result example number is cured the total effectively % of the invalid % of the effective % of %
Slight 661 100
Pulmonary tuberculosis moderate 12 12 2 100
Severe 43 43 5 100
Slight 422 100
Tuberculosis of spine moderate 10 73 100
Severe 22 100
Meningeal tuberculosis moderate 11 100
Severe 33 100
Lymphoid tuberculosis moderate 431 100
Severe 862 100
By above test as seen, this medicine reaches 100% to the total effective rate of pulmonary tuberculosis, tuberculosis of spine, meningeal tuberculosis, lymphoid tuberculosis treatment.
Enumerate model case below with this Drug therapy:
1, open * *, man, 54 years old, hectic 13 years, life-time service tuberculosis chemotherapeutic.Come November 13 calendar year 2001 institute to go to a doctor, cough at that time, expectorant blood, have no appetite, be diagnosed as heavy pulmonary tuberculosis, the cavity is thick wall cavity (CT examination), through obeying this capsule for treating 3 months, cough, expectorant blood disappear, and appetite obviously increases, the gastric ulcer transference cure, CT check cavity is closed, and the expectorant bacterium is turned out cloudy.
2, car * *, the woman, 48 years old, suffer from lymphoid tuberculosis 5 years, cervical region festers and can't bear obstinate.Came here to go to a doctor on March 15th, 2002,, do not see recurrence so far through taking the recovery from illness in 3 months of this capsule.
3, Zhao * *, man, 50 years old, calendar year 2001 is diagnosed as tuberculosis of spine by certain hospital, and hospital is thought needs operative treatment, and the back is because of fearing that postoperative reaches the closed-plaster method of several months, then abandon operation, come my institute's diagnosis and treatment, through taking this capsule after 3 months, the state of an illness is clearly better, can walk with descending, continue medication 2 months,, be almost recovered through X-ray check.

Claims (2)

1, a kind of treatment compound medicine lungy is characterized in that by the following composition of weight proportion formulated:
Radix Stemonae extract 100~190g Herba Lysionoti Pauciflori extract 100~190g
Flos lupuli (Flos Humuli Lupuli) extract 100~190g Flos Sophorae Immaturus extract 100~190g
Herba Artemisiae Annuae extract 100~190g Ramulus et folium taxi cuspidatae Extract 10~90g
Radix Polygoni Multiflori extract 100~190g Radix Cynanchi Atrati extract 100~190g
Rhizoma Polygonati extract 100~190g Semen Armeniacae Amarum extract 10~90g
Cacumen Platycladi extract 10~90g Usnea extract 100~190g
Herba seu Radix Metaplexis hemsleyanae extract 100~190g,
Each extract is that percolate reclaims ethanol at low temperatures, the dry extract of lyophilization gained with each flavor medicinal alcohol percolation percolation.
2, the described a kind of preparation method for the treatment of compound medicine lungy of claim 1, it is characterized in that Radix Stemonae extract with 100~190g, 100~190g Herba Lysionoti Pauciflori extract, 100~190g Flos lupuli (Flos Humuli Lupuli) extract, 100~190g Flos Sophorae Immaturus extract, 100~190g Herba Artemisiae Annuae extract, 10~90g Ramulus et folium taxi cuspidatae Extract, 100~190g Radix Polygoni Multiflori extract, 100~190g Radix Cynanchi Atrati extract, 100~190g Rhizoma Polygonati extract, 10~90g Semen Armeniacae Amarum extract, 10~90g Cacumen Platycladi extract, 100~190g Usnea extract, 100~190g Herba seu Radix Metaplexis hemsleyanae extract is ground into fine powder and crosses 100 mesh sieves, adorn in No. 1 capsule, make oral capsule.
CN 200410060657 2004-07-29 2004-07-29 Compound medicine for treating tuberculosis and its preparing method Expired - Fee Related CN1269518C (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103041266B (en) * 2013-01-25 2014-01-29 张圣军 Medicine for treating pediatric postoperative pneumonia
CN103041269B (en) * 2013-01-25 2015-09-09 于雪芝 A kind of Chinese medicine for the treatment of postoperative pneumonia
CN103656404B (en) * 2013-10-28 2014-08-06 孟祥爱 Traditional Chinese medicine preparation for treating tuberculosis and preparation method

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