CN101116733B - Medicinal pill for clearing away lung heat and treating pulmonary tuberculosis - Google Patents

Abstract

The invention discloses a Qingfei bolus (or Qulao bolus) for treating phthisis in clinical use, in particular to an indolent phthisis which has Western medicine resistance or is allergic to Western medicine. The invention adopts 23 species of herbal pieces prepared for decoction of Chinese medicine such as radices pseudoginseng, Fritillaria roylei Hooker, lily and radices glehniae and so on as raw materials. The invention is made by grinding all the materials into power, screening and evenly mixing so as to produce water pills, lastly drying the pills. The invention has the advantages of wide medicine resources, easy acquisition of ingredients, simple production technology, convenient taking and free from side effects. After the clinical observation, patients, who have taken the medicine, prominently improve the weight and immune ability, completely absorb nidus and remove the symptoms. The invention has the advantages of accurate curative effects, short period of treatment, fast desired result and absence from recurrence, can rather apparently cure not only the indolent phthisis, but also various phthises. The medicine is an ideal medicine for healing phthises.

Description

A kind of medicinal pill for clearing away lung heat and treating pulmonary tuberculosis for the treatment of pulmonary tuberculosis

Technical field:

The present invention relates to a kind of Chinese patent medicine that is used for the treatment of pulmonary tuberculosis in clinical, particularly relate to a kind of treatment has drug resistance or refractory pulmonary tuberculosis disease hypersensitive to Western medicine Chinese patent medicine.

Background technology:

Pulmonary tuberculosis is a kind of infectious disease, also be commonly encountered diseases and frequently-occurring disease, as primary pulmonary tuberculosis, secondary type pulmonary tuberculosis and hematogenous disseminated pulmonary tuberculosis etc. often because of finding late or malpractice, particularly irregular chemotherapy, make tulase produce drug resistance and lasting discharge of bacteria, the cavity is not closed for a long time, and empty wall is thickening gradually, and extensive fibrosis appears in focus; Height with body immunity rises and falls, and focus absorbs, repairs and worsens, progress alternately takes place repeatedly.Pathological changes can be multiple pathology character (ooze out, propagation, cheese, thick wall cavity, pleural thickening, fibrosis) and mixes and exist in the lung, based on thick wall cavity and fiber pathological changes, and Secondary cases bronchiectasis and pulmonary atelectasis is often arranged.Because pathological changes is extensive, pulmonary function is subjected to grievous injury, the lung tissue of not invaded by pathological changes produces compensatory emphysema simultaneously, occur that syndrome of deficiency of lung yin cough, night sweat, out of breath, die Blausucht, dry cough expectorant are few, mixed infection in the spitting of blood, lung, about 1/3 left and right sides patient all has spitting of blood in various degree in ill process.Bring great misery to the patient.Adopt western medicine and medical practitioners to treat for a long time for pulmonary tuberculosis, these drug mains will have Rimactazid, streptomycin, ethambutol always.Though described these antitubercular agent clinical efficacies are relatively good, side effect is quite big, can cause the infringement to liver function, renal function, dysaudia, dizzy, gastrointestinal upset and anaphylaxis.And easily develop immunity to drugs after taking medicine, make the not obvious and extended treatment time of therapeutic effect.Because this class patient lesion portion has a large amount of fiber propagation and cheesy necrosis, regional nodes's blood vessel interrupts, and stasis of blood resistance is obstructed, and conventional tuberculosis medicine is difficult for proving effective.

Summary of the invention;

The present invention is for a kind of medicinal pill for clearing away lung heat and treating pulmonary tuberculosis for the treatment of pulmonary tuberculosis is provided, mainly be that the existing antituberculotics side effect of solution is big, can cause infringement to liver function, renal function, dysaudia, dizzy, gastrointestinal upset and anaphylaxis, and easily develop immunity to drugs the problem that therapeutic effect is not obvious and treatment time is long after taking medicine.

The solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to pulmonary tuberculosis morbidity base reason, with reference to the modern pharmacological research achievement, from motherland's medical treasure-house, filter out the pure natural plant medicine of relieving cough and asthma, living hungry hemostasis, nourishing YIN lung moistening, Qinghua heat-phlegm, heat-clearing and toxic substances removing, by the theory of Chinese medical science prescription, skim the cream off milk, make its performance clearing heat and moistening lung, clearing phlegm and relieving cough, give birth to hungry hemostatic function, thereby accelerate the reparation in pulmonary function, tissue and cavity.

The present invention is the pill of being made by following component and weight proportion:

Radix Notoginseng 50--100 part Bulbus Fritillariae Cirrhosae 60-100 part Bulbus Lilii 30-50 part

Radix Glehniae 15-25 part Radix Asparagi 30-50 part 30-50 Radix Ophiopogonis part

Radix Platycodonis 30-50 part Radix Scrophulariae 15-25 part Cortex Mori 30-50 part

Radix Asteris 15-25 part Radix Rehmanniae 30-50 part Flos Lonicerae 30-60 part

Pseudobulbus Bletillae (Rhizoma Bletillae) 50-100 part Radix Stemonae 50-100 part Rhizoma Chuanxiong 15-25 part

Radix Angelicae Sinensis 30-50 part Radix Paeoniae Alba 30-50 part Radix Astragali 50-10 part

Radix Ginseng 15-25 part Rhizoma Picrorhizae 60-100 part Radix Ranunculi Ternati 0-25 part

Spica Prunellae 0-25 part Herba Houttuyniae 0-25 part.

Optimum weight proportioning of the present invention is:

25 parts of 50 portions of Radix Glehniaes of 100 portions of Bulbus Liliies of 100 parts of Bulbus Fritillariae Cirrhosaes of Radix Notoginseng

25 parts of 50 portions of Radix Scrophulariaes of Radix Asparagi 50 parts of Radix Platycodoniss, 50 parts of Radix Ophiopogonis

60 parts of 50 portions of Flos Loniceraes of 25 portions of Radix Rehmanniae of 50 parts of Radix Asteriss of Cortex Mori

50 parts of 100 parts of Radix Angelicae Sinensis of 100 parts of Radixs Stemonae of 25 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of Rhizoma Chuanxiong

100 parts of 25 parts of Rhizoma Picrorhizae of 100 parts of Radix Ginsengs of 50 parts of Radixs Astragali of the Radix Paeoniae Alba

25 parts of 25 parts of Herba Houttuyniae of 25 portions of Radix Ranunculi Ternatis of Spica Prunellae.

The present invention has the medicinal efficacy of hemostasis blood stasis dispelling, relieving cough and asthma, moistening the lung and resolving phlegm, removing toxic substances and promoting granulation.Superfine product Radix Notoginseng with hemostasia and dissipation blood stasis is monarch, can make unobstructed vessel, improves the microcirculation of local organization, increases the local organization blood flow, improves the drug level in the focus, and the absorption that helps focus transforms, and can effectively prevent the spitting of blood symptom.Be aided with Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Radix Glehniae, Radix Asparagi, Radix Ophiopogonis, Radix Platycodonis, Radix Scrophulariae, Cortex Mori, Radix Asteris, Rhizoma Picrorhizae, the Radix Rehmanniae, Radix Ranunculi Ternati, Herba Houttuyniae, Spica Prunellae removing heat from the lung and dissipating phlegm, nourishing YIN and moistening the lung.Assistant makes with Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Astragali, ginseng qi-tonifying and promotes the production of body fluid with Flos Lonicerae, Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Stemonae, the antibacterial detoxifcation of Rhizoma Chuanxiong.All medicines are united utilization, can effectively suppress the growth of tulase, promote the absorption of focus, thereby accelerate the repair process in pulmonary function, tissue and cavity, have also demonstrated fully lung moistening simultaneously and have supported lung, the Therapeutic Principle of strengthening vital QI to eliminate pathogenic factors.

The present invention is a raw material with the pure natural plant medicine, and the medicine source is extensive, and raw material is easy to get, preparation technology is simple, taking convenience, and it replaces Western medicine with Chinese medicine, change traditional therapeutic modality to pulmonary tuberculosis, without any side effects, body weight and immunocompetence obviously increase after clinical observation is taken medicine, and focus absorbs fully, compared with prior art, short treating period, instant effect does not recur.Not only drug resistance, allergy, refractory pulmonary tuberculosis are had suitable notable therapeutic effect, and all evident in efficacy to all kinds of (essential, secondary type and hematogenous spread type) pulmonary tuberculosis.This medicine is present more satisfactory anti-tuberculosis drugs, has vast market prospect.

The specific embodiment:

The present invention is produced by following method:

The present invention is by the above optimum weight proportioning weighting raw materials (prepared slices of Chinese crude drugs), and these 23 flavor prepared slices of Chinese crude drugs are ground into fine powder, sieves, mixing, makes water pill, and cold drying promptly.

Character: the present invention is that light brown is to dark-brown water pill; Feeble QI perfume (or spice), mildly bitter flavor.

Usage and dosage: a 7-14 gram of oral adult (1-2 bottle cap), 3 times on the one.7-9 year child 3 times on the one, one time 3.5 gram, child more than 10 years old, 3 times on the one, one time 7 gram, warm water delivery service.

The present invention has lung heat clearing lung moistening, tonifying the lung, clearing phlegm and relieving cough, the effect of promoting regeneration of the tissue and arresting bleeding.Clinical various pulmonary tuberculosis and drug resistance, the irritated refractory pulmonary tuberculosis of curing mainly, lymphoid tuberculosis and the sputum mixed with blood that causes thereof, chronic cough, night sweat, feverish sensation in the palms and soles, sensation of oppression over the chest with shortness of breath, loss of appetite, become thin, disease such as weak.In the past few years pass through of the clinical trial of Siping City tuberculosis hospital, be subjected to quite satisfied effect 220 routine lungers.This clinical data is as follows:

We select 220 examples at random in the tuberculosis patient that this institute goes to a doctor, male's 130 examples account for 59.1%, and women's 90 examples account for 40.9%.Reckling is 11 years old in age, the maximum 82 years old, 35.32 years old mean age.56 examples below 20 years old wherein, 110 examples in 21-50 year, 34 examples in 51-60 year, 20 examples more than 61 years old.Drug tolerance pulmonary tuberculosis 53 examples, anaphylaxis pulmonary tuberculosis 36 examples, primary pulmonary tuberculosis, secondary type pulmonary tuberculosis and hematogenous disseminated pulmonary tuberculosis amount to 131 examples.

Diagnostic criteria: drug tolerance pulmonary tuberculosis is meant antiphthisic Western medicine is produced drug resistance and curative effect is not obvious; The anaphylaxis pulmonary tuberculosis is meant that the patient can't use antiphthisic Western medicine allergy; Primary pulmonary tuberculosis is when resistance of human body reduces, and the tulase of subintrusion body forms primary lesion, about tuberculosis that occurs in pulmonary more than 90% in pulmonary or intestinal wall at the beginning of respiratory tract or digestive tract; Secondary type pulmonary tuberculosis is to occur based on propagation, infiltration, cheese pathological changes or based on the pulmonary tuberculosis of the multiple pathological change in cavity.Hematogenous disseminated pulmonary tuberculosis be meant tulase enter blood capable after, wide dispersion is to lung or each organ and the pulmonary tuberculosis that causes.

Therapeutic Method: the each 7--14 gram of oral medicine of the present invention, three times on the one, 30 days is a course of treatment, time-out is used and is treated relevant medicine in treatment.Avoid raw meat, peppery irritable food in the medication.

Criterion of therapeutical effect:

1, recovery from illness: symptom is most of to disappear, and does not recur in 1 year, and corresponding main physico-chemical examination recovers normal or be clearly better (focus calcification of X-ray sheet or absorption substantially.)

2, produce effects: cardinal symptom disappears, and half a year to one, a year main physico-chemical examination took a turn for the better.(the X-ray sheet is than the apparent in view improvement of anter).

3, effective: cardinal symptom disappears substantially, and corresponding main physico-chemical examination recovers normal or take a turn for the better (X-ray sheet focus is dwindled, calcification) substantially.

4, invalid: cardinal symptom no change, corresponding main physico-chemical examination no change.(X-ray examination no change or increase the weight of).Its clinical observation on the therapeutic effect result sees following table for details:

Clinical observation on the therapeutic effect is table as a result

Above-mentioned observation of curative effect result shows: the present invention is 98% to treatment pulmonary tuberculosis effective percentage, is 94% to treatment drug tolerance pulmonary tuberculosis effective percentage, is 91% to anaphylaxis pulmonary tuberculosis effective percentage, and comprehensive effective percentage is 96.33%.This shows determined curative effect of the present invention, suitable applying.

In order further to show the situation of the present invention's doing well,improving before and after patient takes medicine, again 220 routine part patients are checked routine urinalysis, liver function, renal function etc.The contrast review result has no significant change before and after taking medicine, and illustrates that this medicine has no side effect to liver, kidney and damages.Details see the following form:

Doing well,improving information slip before and after 220 routine patients take medicine

Visible the present invention is to there being notable difference in the table before and after the above-mentioned symptom medication.The p value is all less than 0.05.

Medical record is given an example:

The Wang, woman 42 years old, the teacher, the 4-9 month in 1998 did not feel any better successively in tuberculosis hospital, sanatorium's hospitalization.Go to a doctor diagnosis at the beginning of 1998 10 months to Bethune medical university: in upper left lung infiltrative pulmonary tuberculosis, progressive stage, concurrent infection (observe omnidistance X-ray sheet, pulmonary tuberculosis is never controlled), the back is to my institute's treatment.Cough, pyoptysis expectorant are uncomfortable in chest when coming, breathe hard, and low grade fever, night sweat, weak, feverish sensation in the palms and soles, back is ached.Look into: chronic painful sickly complexion, the end seat is breathed lip cyanosis, about 45 kilograms of body weight.Day symptom of taking medicine surplus in the of ten takes a turn for the better, one month no uncomfortable in chest, breathe hard, tussicula, no expectorant do not have and generate heat and night sweat, body weight increases to 50 kilograms.The X line: the tuberculosis upward swing, symptom all disappeared in two months, took medicine altogether four months, and focus absorbs fully, and the expectorant bacterium is turned out cloudy.

The summary conclusion:

The present invention cures mainly all kinds pulmonary tuberculosis and drug resistance, irritated refractory pulmonary tuberculosis, lymphoid tuberculosis, tuberculoma.Really have lung heat clearing lung moistening, tonifying the lung, clearing phlegm and relieving cough through clinical experiment, the functional effect of promoting regeneration of the tissue and arresting bleeding.Can effectively impel the closed quickening in cavity, focus good absorbing, symptom to eliminate and thoroughly do not recur.One month is a course of treatment, and can obviously take effect a course of treatment, and can cure general two to four courses of treatment.Determined curative effect of the present invention is stable, takes safe and reliablely, has no side effect, and the patient easily accepts, and not only drug resistance, allergy, refractory pulmonary tuberculosis is had suitable notable therapeutic effect, and all evident in efficacy to all kinds of pulmonary tuberculosis.This medicine is present more satisfactory anti-tuberculosis drugs.Be suitable for clinical application.

Claims (1)

1. medicinal pill for clearing away lung heat and treating pulmonary tuberculosis for the treatment of pulmonary tuberculosis, it is characterized in that: it is the pill of being made by following component and weight proportion:

25 parts of 50 portions of Radix Glehniaes of 100 portions of Bulbus Liliies of 100 parts of Bulbus Fritillariae Cirrhosaes of Radix Notoginseng

25 parts of 50 portions of Radix Scrophulariaes of Radix Asparagi 50 parts of Radix Platycodoniss, 50 parts of Radix Ophiopogonis

60 parts of 50 portions of Flos Loniceraes of 25 portions of Radix Rehmanniae of 50 parts of Radix Asteriss of Cortex Mori

50 parts of 100 parts of Radix Angelicae Sinensis of 100 parts of Radixs Stemonae of 25 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of Rhizoma Chuanxiong

100 parts of 25 parts of Rhizoma Picrorhizae of 100 parts of Radix Ginsengs of 50 parts of Radixs Astragali of the Radix Paeoniae Alba

25 parts of 25 parts of Herba Houttuyniae of 25 portions of Radix Ranunculi Ternatis of Spica Prunellae.