CN101850084B - Chinese medicinal composition for treating tuberculosis and method for preparing same - Google Patents
Chinese medicinal composition for treating tuberculosis and method for preparing same Download PDFInfo
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- CN101850084B CN101850084B CN2010101870545A CN201010187054A CN101850084B CN 101850084 B CN101850084 B CN 101850084B CN 2010101870545 A CN2010101870545 A CN 2010101870545A CN 201010187054 A CN201010187054 A CN 201010187054A CN 101850084 B CN101850084 B CN 101850084B
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Abstract
The invention discloses a Chinese medicinal composition for treating tuberculosis and a method for preparing the same. The Chinese medicinal composition is prepared from astragalus, sessile stemona root, unibract fritillary bulb, common bletilla pseudobulb, radix rehmanniae preparata and dwarf lilyturf tuber. Pharmacodynamic and clinical tests show that the Chinese medicinal composition has an obvious therapeutic effect on the tuberculosis; and clinical observation shows no toxic or side effects. The Chinese medicinal composition has the advantage of safe clinical medication.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to the phthisical Chinese medicine composition of treatment, the invention still further relates to the method for preparing of this Chinese medicine composition, belong to the treatment by Chinese herbs field of pulmonary tuberculosis disease.
Background technology
Pulmonary tuberculosis is the chronic infectious disease that is caused by tubercule bacillus (tubercle bacillus), can involve a plurality of organs of whole body, but the most common with pulmonary tuberculosis.Tuberculosis is commonly called as " consumptive disease ", is the infection that causes in the tubercule bacillus intrusive body, is the incidental a kind of chronic and deferred infectious disease of adolescence.Can fall ill throughout the year, 15 years old to 35 years old teenager is age peak year occurred frequently lungy.4～8 weeks of incubation period.Wherein 80% occur in pulmonary, but the also secondary infection of other positions.Mainly through respiratory infectious, the source of infection is the lunger of contact discharge of bacteria.People's living standard after liberation improves constantly, and tuberculosis is basic controlling, but in recent years, along with environmental pollution and spreading of AIDS, tuberculosis is staged a comeback again, and sickness rate rises to some extent.
Though the phthisical Chinese medicine composition of existing treatment all has certain curative effect to pulmonary tuberculosis, all in various degree to exist curative effect remarkable inadequately, the not high defective of safety haves much room for improvement.
Summary of the invention
The present invention's technical problem at first to be solved is the deficiency that overcomes prior art, provides a kind of and can effectively treat phthisical Chinese medicine composition;
Another technical problem to be solved by this invention provides a kind of method for preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention realizes through following technical scheme:
The phthisical Chinese medicine composition of a kind of treatment, by the Radix Astragali, the Radix Stemonae, Bulbus Fritillariae Cirrhosae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rehmanniae Preparata and Radix Ophiopogonis process;
In order to reach better therapeutic effect, the weight portion of each crude drug is preferably: Radix Astragali 125-150 part, Radix Stemonae 50-80 part, Bulbus Fritillariae Cirrhosae 50-80 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 50-80 part, Radix Rehmanniae Preparata 80-120 part, Radix Ophiopogonis 50-80 part;
Preferred, the weight portion of each crude drug is: 133 parts of the Radixs Astragali, 66 parts of the Radixs Stemonae, 66 parts of Bulbus Fritillariae Cirrhosaes, 66 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 100 parts of Radix Rehmanniae Preparata, 66 parts of Radix Ophiopogonis.
Chinese medicine composition of the present invention is based on the inventor to pathogenetic research of pulmonary tuberculosis deep layer and Therapeutic Principle thereof; Simultaneously according to inventor clinical experience and pharmaceutical research achievement for many years; Filter out nourishing YIN to lower pathogenic fire; Support the solid gold of lung, moisturize the crude drug of rather coughing, form according to certain weight proportion prescription.
The used crude drug of the present invention all can be bought from common Chinese material shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form; For example disintegrating agent, lubricant, adhesive etc.; Method of Chinese medicinal with routine is prepared into any oral formulations commonly used; Wherein, described oral formulations can be pill, capsule, tablet, powder, granule etc., is preferably capsule.
A kind of method for preparing of Chinese medicine composition of the present invention: after each crude drug of the present invention taken by weighing by said weight portion proportioning, pulverize, sieving (can be the 300-800 mesh sieve for example, promptly get.Certainly, after also can each crude drug being pulverized, add required adjuvant or the excipient of preparations shaping, be prepared into capsule, tablet or pill according to conventional method.
The another kind of method for preparing of Chinese medicine composition of the present invention comprises:
(1), takes by weighing each crude drug by said weight proportion;
(2) Radix Astragali and Radix Ophiopogonis are extracted with alcohol heat reflux, filter merging filtrate, decompression recycling ethanol; Be concentrated into clear paste, use purification by macroporous resin then, earlier, discard leacheate with 30% ethanol drip washing; The ethanol elution of reuse 70% is collected eluent, reclaims ethanol, is concentrated into dried; Be ground into fine powder, obtain component 1, subsequent use;
(3) get the Radix Stemonae and Bulbus Fritillariae Cirrhosae and use the alcoholic solution reflux, extract,, filter, filtrate recycling ethanol is concentrated into clear paste; Use purification by macroporous resin then, earlier, discard leacheate, the ethanol elution of reuse 70% with 30% ethanol drip washing; Collect eluent, reclaim ethanol, be concentrated into dried; Be ground into fine powder, obtain component 2, subsequent use;
(4) with Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Rehmanniae Preparata decocte with water, to filter, filtrating concentrates, 30% ethanol precipitation, hold over night, centrifugal, supernatant reuse 80% ethanol precipitation, hold over night, centrifugal, the deposition dehydration, drying obtains component 3, and is subsequent use;
(5) component 1, component 2, component 3 are mixed with adjuvant, be prepared into oral formulations according to preparations shaping method.
Preferably, in the step (2) the 70-90% alcohol heat reflux that adds the Radix Astragali, Radix Ophiopogonis 4-10 times of weight is extracted 2-4 time, each 1.5h, filtration, merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.45 clear paste; Described macroporous resin is the D101 macroporous resin preferably;
Preferably, in the step (3) Radix Stemonae, Bulbus Fritillariae Cirrhosae added the alcoholic solution reflux, extract, 2 times of the 70-90% of 4-10 times of weight, each 2 hours, filter, merging filtrate, filtrate recycling ethanol is concentrated into relative density and is 1.35 clear paste; Described macroporous resin is the D101 macroporous resin preferably;
Preferably, in the step (4) with Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Rehmanniae Preparata decocte with water 1-3 time, each 2h.
Pharmacodynamics and clinical test results show that Chinese medicine composition of the present invention has significant curative effect for pulmonary tuberculosis, and any toxicity is not seen in clinical observation, Chinese medicine composition clinical drug safety of the present invention.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on factors such as concrete dosage form, patient's age, health status.As guidance: usage and dosage: capsule, each capsule content 0.5 gram, each oral 10 to 15.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment with form or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall in protection scope of the present invention the details of technical scheme of the present invention.
The preparation of embodiment 1 capsule
Take by weighing each raw material by following weight: Radix Astragali 133g Radix Stemonae 66g Bulbus Fritillariae Cirrhosae 66g Pseudobulbus Bletillae (Rhizoma Bletillae) 66g Radix Rehmanniae Preparata 100g 66g Radix Ophiopogonis;
Above Six-element extracts 80% alcohol heat reflux that adds the Radix Astragali, Radix Ophiopogonis 8 times of weight 3 times earlier, and each 1.5h filters; Merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.45 clear paste, uses the D101 purification by macroporous resin then; Earlier, discard leacheate, the ethanol elution of reuse 70%, collection eluent with 30% ethanol drip washing; Reclaim ethanol, be concentrated into driedly, be ground into fine powder, be total saponins component (component 1);
Get the Radix Stemonae, Bulbus Fritillariae Cirrhosae again and add 80% the alcoholic solution reflux, extract, 2 times of 8 times of amounts, each 2 hours, filter merging filtrate; Filtrate recycling ethanol is concentrated into relative density and is 1.35 clear paste, uses the D101 purification by macroporous resin then, earlier with 30% ethanol drip washing; Discard leacheate, the ethanol elution of reuse 70% is collected eluent, reclaims ethanol; Be concentrated into driedly, be ground into fine powder, be total alkaloids component (component 2);
With all the other two flavor Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Rehmanniae Preparata decocte with water 2 times, 2h at every turn, merging filtrate is concentrated into certain volume; Earlier use 30% ethanol precipitation, hold over night, centrifugal; Supernatant reuse 80% ethanol precipitation, hold over night, centrifugal; Deposition is used 95% ethanol dehydration, and drying promptly gets purified polysaccharide component (component 3);
At last total saponins, total alkaloids and polysaccharide component are mixed with suitable adjuvant, granulate, drying, granulate, total mixing incapsulates, and processes 100.
The preparation of embodiment 2 capsules
Take by weighing each raw material by following weight: Radix Astragali 150g Radix Stemonae 80g Bulbus Fritillariae Cirrhosae 80g Pseudobulbus Bletillae (Rhizoma Bletillae) 80g Radix Rehmanniae Preparata 120g 80g Radix Ophiopogonis;
Above Six-element extracts 80% alcohol heat reflux that adds the Radix Astragali, Radix Ophiopogonis 10 times of weight 3 times earlier, and each 1.5h filters; Merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.45 clear paste, uses the D101 purification by macroporous resin then; Earlier, discard leacheate, the ethanol elution of reuse 70%, collection eluent with 30% ethanol drip washing; Reclaim ethanol, be concentrated into driedly, be ground into fine powder, be total saponins component (component 1);
Get the Radix Stemonae, Bulbus Fritillariae Cirrhosae again and add 80% the alcoholic solution reflux, extract, 2 times of 10 times of weight, each 2 hours, filter merging filtrate; Filtrate recycling ethanol is concentrated into relative density and is 1.35 clear paste, uses the D101 purification by macroporous resin then, earlier with 30% ethanol drip washing; Discard leacheate, the ethanol elution of reuse 70% is collected eluent, reclaims ethanol; Be concentrated into driedly, be ground into fine powder, be total alkaloids component (component 2);
With all the other two flavor Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Rehmanniae Preparata decocte with water 2 times, 2h at every turn, merging filtrate is concentrated into certain volume; Earlier use 30% ethanol precipitation, hold over night, centrifugal; Supernatant reuse 80% ethanol precipitation, hold over night, centrifugal; Deposition is used 95% ethanol dehydration, and drying promptly gets purified polysaccharide component (component 3);
At last total saponins, total alkaloids and polysaccharide component are mixed with suitable adjuvant, granulate, tabletting promptly gets.
The preparation of embodiment 3 granules
Take by weighing each raw material by following weight: Radix Astragali 125g Radix Stemonae 50g Bulbus Fritillariae Cirrhosae 50g Pseudobulbus Bletillae (Rhizoma Bletillae) 50g Radix Rehmanniae Preparata 80g 50g Radix Ophiopogonis;
Above Six-element extracts 80% alcohol heat reflux that adds the Radix Astragali, Radix Ophiopogonis 6 times of weight 3 times earlier, and each 1.5h filters; Merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.45 clear paste, uses the D101 purification by macroporous resin then; Earlier, discard leacheate, the ethanol elution of reuse 70%, collection eluent with 30% ethanol drip washing; Reclaim ethanol, be concentrated into driedly, be ground into fine powder, be total saponins component (component 1);
Get the Radix Stemonae, Bulbus Fritillariae Cirrhosae again and add 80% the alcoholic solution reflux, extract, 2 times of 6 times of weight, each 2 hours, filter merging filtrate; Filtrate recycling ethanol is concentrated into relative density and is 1.35 clear paste, uses the D101 purification by macroporous resin then, earlier with 30% ethanol drip washing; Discard leacheate, the ethanol elution of reuse 70% is collected eluent, reclaims ethanol; Be concentrated into driedly, be ground into fine powder, be total alkaloids component (component 2);
With all the other two flavor Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Rehmanniae Preparata decocte with water 2 times, 2h at every turn, merging filtrate is concentrated into certain volume; Earlier use 30% ethanol precipitation, hold over night, centrifugal; Supernatant reuse 80% ethanol precipitation, hold over night, centrifugal; Deposition is used 95% ethanol dehydration, and drying promptly gets purified polysaccharide component (component 3);
At last total saponins, total alkaloids and polysaccharide component are mixed with suitable adjuvant, granulate, drying, granulate promptly gets.
The clinical efficacy of Test Example 2 traditional Chinese medicine composition for treating pulmonary tuberculosis of the present invention is summed up
One, clinical physical data: accept 68 lungers of example altogether for medical treatment, 25 years old mean age, be the out-patient through making a definite diagnosis.
Two, the capsule that Therapeutic Method: embodiment 1 is prepared, sooner or later each 1 time oral, individual capsule content 0.5 gram, each oral 10 to 15, stop using menstrual period.3 months is a course of treatment.
Three, therapeutic outcome
The 68 routine lungers that accepted for medical treatment take Chinese medicine composition of the present invention after 2 courses of treatment, produce effects 37 examples, effective 25 examples, invalid 6 examples, total effective rate 91.1%.
Clinical test results shows that Chinese medicine composition of the present invention has notable therapeutic effect for pulmonary tuberculosis, and any toxicity is not seen in clinical observation, and Chinese medicine composition drug safety of the present invention is described.
Claims (9)
1. the phthisical Chinese medicine composition of treatment is characterized in that, is processed by following crude drug: the Radix Astragali, the Radix Stemonae; Bulbus Fritillariae Cirrhosae, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rehmanniae Preparata and Radix Ophiopogonis; The weight portion of each crude drug is: Radix Astragali 125-150 part, Radix Stemonae 50-80 part, Bulbus Fritillariae Cirrhosae 50-80 part; Pseudobulbus Bletillae (Rhizoma Bletillae) 50-80 part, Radix Rehmanniae Preparata 80-120 part, Radix Ophiopogonis 50-80 part.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that the weight portion of each crude drug is: 133 parts of the Radixs Astragali, 66 parts of the Radixs Stemonae, 66 parts of Bulbus Fritillariae Cirrhosaes, 66 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 100 parts of Radix Rehmanniae Preparata, 66 parts of Radix Ophiopogonis.
3. according to any one described Chinese medicine composition of claim 1-2, it is characterized in that: this Chinese medicine composition is any acceptable clinically preparation.
4. according to the described Chinese medicine composition of claim 3, it is characterized in that: described preparation is an oral formulations.
5. according to the described Chinese medicine composition of claim 4, it is characterized in that: described oral formulations is capsule, tablet, granule, powder, pill, oral liquid, syrup or drop pill.
6. method for preparing any one said Chinese medicine composition of claim 1-2, this method may further comprise the steps: take by weighing each crude drug by said weight proportion; After each crude drug is pulverized, add required adjuvant or the excipient of preparations shaping, be prepared into capsule, tablet or pill.
7. method for preparing any one said Chinese medicine composition of claim 1-2, this method may further comprise the steps:
(1), takes by weighing each crude drug by said weight proportion;
(2) Radix Astragali and Radix Ophiopogonis are extracted with alcohol heat reflux, filter merging filtrate, decompression recycling ethanol; Be concentrated into clear paste, use purification by macroporous resin then, earlier, discard leacheate with 30% ethanol drip washing; The ethanol elution of reuse 70% is collected eluent, reclaims ethanol, is concentrated into dried; Be ground into fine powder, obtain component 1, subsequent use;
(3) get the Radix Stemonae and Bulbus Fritillariae Cirrhosae and use the alcoholic solution reflux, extract,, filter, filtrate recycling ethanol is concentrated into clear paste; Use purification by macroporous resin then, earlier, discard leacheate, the ethanol elution of reuse 70% with 30% ethanol drip washing; Collect eluent, reclaim ethanol, be concentrated into dried; Be ground into fine powder, obtain component 2, subsequent use;
(4) with Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Rehmanniae Preparata decocte with water, to filter, filtrating concentrates, 30% ethanol precipitation, hold over night, centrifugal, supernatant reuse 80% ethanol precipitation, hold over night, centrifugal, the deposition dehydration, drying obtains component 3, and is subsequent use;
(5) component 1, component 2, component 3 are mixed with adjuvant, be prepared into oral formulations according to preparations shaping method.
8. according to the described method of claim 7, it is characterized in that: in the step (2) the 70-90% alcohol heat reflux that adds the Radix Astragali, Radix Ophiopogonis 4-10 times of weight is extracted 2-4 time each 1.5h; Filter; Merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.45 clear paste; Described macroporous resin is the D101 macroporous resin;
The alcoholic solution reflux, extract, 2 times that in the step (3) Radix Stemonae, Bulbus Fritillariae Cirrhosae is added the 70-90% of 4-10 times of weight, each 2 hours, filter, merging filtrate, filtrate recycling ethanol is concentrated into relative density and is 1.35 clear paste; Described macroporous resin is the D101 macroporous resin;
In the step (4) with Pseudobulbus Bletillae (Rhizoma Bletillae) and Radix Rehmanniae Preparata decocte with water 1-3 time, each 2h.
9. any one said Chinese medicine composition of claim 1-2 is treated the purposes in the pulmonary tuberculosis medicine in preparation.
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| CN2010101870545A CN101850084B (en) | 2010-05-31 | 2010-05-31 | Chinese medicinal composition for treating tuberculosis and method for preparing same |
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| CN2010101870545A CN101850084B (en) | 2010-05-31 | 2010-05-31 | Chinese medicinal composition for treating tuberculosis and method for preparing same |
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| CN101850084B true CN101850084B (en) | 2012-11-28 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547562A (en) * | 2014-12-08 | 2015-04-29 | 张仁勇 | Medicine for treating pulmonary tuberculosis and preparation method thereof |
| CN105497512A (en) * | 2015-12-23 | 2016-04-20 | 广西南岜仔科技有限公司 | Traditional Chinese medicine composition having effects of dispelling dampness, supporting health and removing tuberculosis |
| CN106666053A (en) * | 2017-02-27 | 2017-05-17 | 长江师范学院 | Preparation method of early-maturing pear agar fruit jelly |
| CN109806353B (en) * | 2019-03-15 | 2021-06-22 | 周富淦 | A Chinese medicinal pill for treating pulmonary tuberculosis, and its preparation method |
| CN110638961A (en) * | 2019-10-23 | 2020-01-03 | 何增义 | Traditional Chinese medicine composition for treating tuberculosis and preparation method thereof |
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| CN101116733A (en) * | 2006-08-04 | 2008-02-06 | 张立梅 | Medicinal pill for clearing away lung heat and treating pulmonary tuberculosis |
| CN101417100A (en) * | 2008-12-09 | 2009-04-29 | 通化永仓药业有限公司 | Medicine for treating secondary lung tuberculosis and preparation method thereof |
| CN101461913A (en) * | 2008-11-27 | 2009-06-24 | 浙江省中西医结合医院 | Chinese medicinal composition for treating tuberculosis |
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2010
- 2010-05-31 CN CN2010101870545A patent/CN101850084B/en not_active Withdrawn - After Issue
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| CN101116733A (en) * | 2006-08-04 | 2008-02-06 | 张立梅 | Medicinal pill for clearing away lung heat and treating pulmonary tuberculosis |
| CN101461913A (en) * | 2008-11-27 | 2009-06-24 | 浙江省中西医结合医院 | Chinese medicinal composition for treating tuberculosis |
| CN101417100A (en) * | 2008-12-09 | 2009-04-29 | 通化永仓药业有限公司 | Medicine for treating secondary lung tuberculosis and preparation method thereof |
| CN101647972A (en) * | 2009-08-06 | 2010-02-17 | 颜昌和 | Traditional Chinese medicine for treating phthisis |
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