CN104288514A - Traditional Chinese medicine for treating hyperthyroidism - Google Patents
Traditional Chinese medicine for treating hyperthyroidism Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating hyperthyroidism. The traditional Chinese medicine for treating hyperthyroidism is prepared from the following materials in parts by weight: 7 parts of prunella vulgaris, 6 parts of airpotato yam, 2 parts of gentian, 5 parts of appendiculate cremastra pseudobulb, 13 parts of radix scrophularise, 12 parts of sinomenium acutum, 13 parts of thallus eckloniae and 4 parts of heracleum hemsleyanum michaux. Clinical experiments prove that the traditional Chinese medicine for treating hyperthyroidism can safely and effectively treat hyperthyroidism.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to one and be used for the treatment of hyperthyroid Chinese medicine.
Background technology
The high disease of thyroid function is called for short " hyperthyroidism ", is due to the too much thyroxin of thyroid synthesis release, causes the hyperfunction and sympathetic activation of organism metabolism, causes cardiopalmus, perspiration, feed and the just secondary disease increasing and lose weight.Most of patients also usually has the symptoms such as expophthalmos, blepharoedema, visual deterioration simultaneously.At present, western medical treatment mainly contains three kinds of methods, Anti-thyroid Medicine, radioiodine therapy and operative treatment, but has light or heavy untoward reaction, complication and surgical contraindication, is difficult to radical cure.Anti-thyroid Medicine wide accommodation, no matter child adult, male or women, mild or serious symptom hyperthyroidism, First episode or hyperthyroidism recurrence, anemia of pregnant woman or lactating female hyperthyroidism can use Drug therapy.Antithyroid drug has two kinds---and imidazoles and thiouracil class, represent medicine and be respectively thiamazole (also known as " thiamazole ") and propylthiouracil (also known as " third is phonetic "), but the Drug therapy cycle is long and easily recur, and relapse rate is 50%.Without " hyperthyroidism " name of disease in Chinese medical book, according to its clinical symptoms and sign, there is the record of " goiter " diagnosis and treatment similar to it, successively have " wart " in successive dynasties medical literature, " goiter ", " goiter ", the record of names of disease such as " wart capsules ", summarise simple goiter, hyperthyroidism, thyroid adenoma, thyroiditis, the diseases such as thyroid carcinoma, many by depressed emotion, depressedly not change, body fluid is condensed into expectorant, qi depression to blood stasis, gas, expectorant, stasis of blood three ties mutually and forms in cervical region, or by the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, the husky diseases caused by retention of the body fluid gas cut of hummock is violated, or water and soil is unsuitable, all can cause QI and blood stasis, meridians obstruction forms primary disease.
Medical material present Research involved in the present invention is as follows:
Spica Prunellae [another name] sunset sentence, Nedong, swallow face, Mai Xia are withered, ferrum color grass, excellent stigma is colored, lantern is first-class [source] labiate Spica Prunellae or the long fruit ear being preced with Spica Prunellae.Spica Prunellae, in the annual 5-6 month, when spica becomes sepia, selects fine day, has cut herb, be bundled into wisp, or cut spica, dries or using fresh herb.The ground such as [habitats distribution] is distributed in northeast and Shanxi, Shandong, inculcates, Zhejiang, Anhui, Jiangxi.[nature and flavor] bitter in the mouth; Pungent; Cold in nature.[return through] returns liver; Gallbladder meridian.[function cures mainly] liver heat removing and eyesight improving; Powder detoxifcation.Argument is photophobia also; Ophthalmalgia; Have a headache dizzy; Tinnitus; Scrofula; Goiter; Acute mastitis; Mumps; Carbuncle furuncle and phyma poison; Acute hepatitis, chronic hepatitis; Hypertension.[usage and dosage] takes orally: decoct soup, 6-15g, heavy dose of available to 30g; Endure cream or enter ball, loose.Use of a specified duration: appropriate, decocts washing or smashes deposited.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Dioscoreae Bulbiferae [another name] xanthate, xanthate root, bitter medicine, Pseudobulbus cremastrae seu pleiones, gold thread hang the tuber of [source] Dioscoreaceae plant Dioscorea bulbifera L.es such as Rana limnocharis.Excavate in the winter time after Rhizoma Dioscoreae Bulbiferae plantation 2-3, tuber footpath is added work medicine slightly at more than 30cm, and remaining can continue cultivation 1 year.Wash away earth, after cutting off fibrous root, crosscut becomes the sheet of thick 1cm, and solarization or a heatable brick bed are done, or using fresh herb.[nature and flavor] are bitter; Cold; Mild toxicity.[function cures mainly] eliminating stagnation disappears wart; Heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main goiter; Sore throat; Carbuncle sore tumefacting virus; Venom; Tumor; Spit blood; Epistaxis; Spitting of blood; Pertussis; Lung-heat cough with asthma.[usage and dosage] takes orally: decoct soup, 3-9g; Or infusing drugs in wine; Grind 1-2g into powder.External: appropriate, fresh goods is smash deposited; Or grind tune number into powder; Or mill juice is coated with.[extracts] " China's book on Chinese herbal medicine "
The trip of Radix Gentianae [another name] mound, careless Radix Gentianae, Radix Gentianae, bitter Radix Gentianae, Elephantopus scaber L. etc. [source] are gentianaceae plant Radix Gentianae, the root welding technology of Gentiana manshurica, G. triflora and Yunnan Radix Gentianae.Spring, autumn excavate, with in 10 months autumns, that the last ten-days period excavate quality is better, selects large removing stem and leaf, cleaning, drying.Little kind of the root that does is used.[nature and flavor] are bitter; Cold in nature.[function cures mainly] heat clearing and damp drying; Eliminating pathogen in the liver is calmed the frightened.[usage and dosage] is oral: decoct soup, 3-6g; Or enter ball, loose.External: appropriate, decocts washing; Or grind tune into powder and put on the skin.[extracts] " China's book on Chinese herbal medicine "
The pseudobulb of [source] the orchid Cremastra appendiculatas such as Pseudobulbus Cremastrae Seu Pleiones [another name] golden snuff, Herba pyrolae japonicae, Pseudobulbus Cremastrae seu Pleiones, Rhizoma sagittariae sagittifoliae, Pseudobulbus cremastrae seu pleiones, PSEUDOBULBUS CREMASTRAE APPENDICULATAE, mud ice, pleione bulbocodioides.Summer and autumn excavates, and removes stem and leaf, fibrous root, cleans, after steaming, dry in the air to half-dried, then dry.[nature and flavor] sweet in the mouth; Micro-pungent; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds.Main carbuncle malignant boil; Scrofula tuberculosis; Pharyngalgia sore throat; Serpentis, insect bite wound.[usage and dosage] takes orally: decoct soup, 3-6g; Or mill juice; Or enter ball, loose.External: appropriate, mill juice is coated with; Or grind into powder and dress.[extracts] " China's book on Chinese herbal medicine "
Radix Scrophulariae [another name] Chong Tai, positive horse, Xuan Tai, Radix Scrophulariae, ghost hide, end, salty, by the root of [source] the goatweed Radix Scrophulariaes such as horse and Radix Scrophulariae.Plant 1 year, gather in the crops when stem and leaf is withered in the 10-11 month.Dug Herb, take tuber shine or a heatable brick bed to time half-dried, piling up the careless compacting of lid, treat the inner blackening of tuber through repeatedly piling solarization, then it be extremely absolutely dry to shine (a heatable brick bed).[habitats distribution] northeast, North China and Shandong, Jiangsu, Henan.[nature and flavor] sweet in the mouth; Bitter; Salty; Cold nature.[function cures mainly] clearing away heat and cooling blood; Nourishing YIN to lower pathogenic fire; Detoxicating and resolving stagnation of pathogens.Main warm febrile disease and nutrient blood; Fever of the body; Excessive thirst; Crimson tongue; Send out speckle; Hectic fever due to YIN-deficiency chronic cough; Fidgets due to deficiency is awake not; Constipation is hindered in Tianjin; Order is puckery dim-sighted; Throat larynx swells and ache; Scrofula sucutaneous nodule; Skin sore.[usage and dosage] takes orally: decoct soup, 9-15g; Or enter ball, loose.External: appropriate, smashes to apply or grind into powder and dresses.[extracts] " China's book on Chinese herbal medicine "
Sinomenium acutum [another name] seeks Radix seu Caulis fici Martinii, Caulis Sinomenii, Yunnan Radix Stephaniae Tetrandrae, Fructus Aristolochiae Kwangsiensis, large Sinomenium acutum, rock are shown in that anxious [source] this product is the rattan of menispermaceous plants Sinomenium acutum or hair Sinomenium acutum.The 6-7 month extracts rattan, removes thin stem branch and leaf, dries, or run through with water, cutting, dry.[nature and flavor] are bitter; Pungent; Flat.[return through] liver; Spleen channel.[function cures mainly] dispelling wind and removing obstruction in the collateral; Removing damp and stopping pain.Main air pain of dampness syndrome; Severe and migratory arthralgia; The arthroncus of knee; Beriberi swells and ache.[usage and dosage] takes orally: decoct soup, 9-15g; Or steep in wine or endure cream clothes.External: appropriate, decocts washing.[extracts] " China's book on Chinese herbal medicine "
Thallus Laminariae (Thallus Eckloniae) [another name] synthetic fibre cloth, extra large Thallus Laminariae (Thallus Eckloniae) [source] this product are the thallus of Laminariaceae (Laminariophyceae) plant Thallus Laminariae (Thallus Eckloniae) and the black Thallus Laminariae (Thallus Eckloniae) of Alariaceae plant, Thallus Laminariae.Summer, autumn gather, and pulled out, dry by marine.[nature and flavor] are salty; Cold; Nontoxic.[return through] liver; Stomach; Kidney; Spleen channel.[function cures mainly] eliminating phlegm and softening indurated mass; Diuretic detumescent.Main scrofula; Goiter; Dysphagic; (Epileptic is ruined) hernia beriberi edema.[usage and dosage] takes orally: decoct soup, 5-15g; Or enter ball, loose.[extracts] " China's book on Chinese herbal medicine "
Radix Angelicae Pubescentis [another name] recklessly king envoy, solely shake grass, solely cunning, root that Sempervivum tectorum, RADIX ANGELICAE PUBESCENTIS from Sichuan of China, meat Radix Angelicae Pubescentis [source] this product are samphire weight tooth Radix Angelicae Sinensis.Culturing and transplanting seedlings in 10-11 month then, live gathers in the crops after 2 years in growth, digs out root, removes withered stem, leaf, shrugs off earth, after airing solid carbon dioxide gas, stack a heatable brick bed upstairs, smoke a heatable brick bed with firewood, when a heatable brick bed is done dry to fifty percent, every Shun Zhi Defend is held together, is bundled into wisp, a heatable brick bed is extremely absolutely dry.[nature and flavor] bitter in the mouth; Pungent; Property micro-wet.[return through] returns kidney; Urinary bladder channel.[function cures mainly] expelling wind and dampness; Dispersing cold for relieving pain.Main anemofrigid-damp arthralgia; Lumbocrural pain; Headache toothache.[usage and dosage] takes orally: decoct soup, 3-10g; Or infusing drugs in wine; Or enter ball, loose.External: appropriate, decocts soup and washes.[extracts] " China's book on Chinese herbal medicine ".
Summary of the invention
The present invention aims to provide one and is used for the treatment of hyperthyroid Chinese medicine, by selecting suitable medical material and proportioning thereof, reaches the hyperthyroid object of safe and effective healing.
In order to achieve the above object, the present invention is by the following technical solutions:
One is used for the treatment of hyperthyroid Chinese medicine, and it is prepared from by the raw medicinal material of following weight proportion: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts.
As preferably, its preparation method is: take: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
As preferably, its preparation method is: take: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
As preferably, its preparation method is: take: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor in October, 2010 ~ 2013 collect patients suffered from hyperthyroidism 72 example of outpatient clinic altogether between year February, all meet hyperthyroidism diagnostic criteria.Wherein, man 28 example, female 42 example; 28 ~ 46 years old age, average 35.1 years old; The course of disease 6 months ~ 5 years, average 1.76.All patients be divided into actual 34 examples for the treatment of group 36 example (actual 35 examples complete test, and 1 example comes off) and matched group 36(to complete test at random, 2 examples come off) example, two groups of number of cases that come off all are less than 10%.The aspects such as two groups of Genders, age, severity extents compare, and no significant difference, has comparability, as table 1-table 3
Table 1 liang group Sex distribution
Table 2 liang group age distribution
Symptom before table 3 liang group patient treatment
Aversion to heat hyperhidrosis before two groups of patient treatments, spiritlessness and weakness, xerostomia are thirsty, insomnia and dreamful sleep, nervous agitation, polyorexia, become thin, hand tremor, frequency of bowel movement etc. compare and adopt t to check, P>0.05, no significant difference, has comparability.To sum up analyze visible two groups of there are no significant in age, sex, severe extent etc. differences, no significant difference (p>0.05), has comparability.
2, test method
2.1 Therapeutic Method
The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times, rapid heart rate is difficult to resistance to receptor and gives propranolol sheet control heart rate.6 months courses for the treatment of.
The oral thiamazole of matched group, takes by its description, gives propranolol sheet and control heart rate when rapid heart rate is difficult to tolerance.6 months courses for the treatment of.
All patients all fully have a rest, and avoid direct stimulation, abundant nutrition, avoid feed containing iodine food, medicine and pungent food, avoid drinking, smoke, strong tea and coffee.
All patients treatments period monthly looks into serum FT 3, a FT4, carries out curative effect statistics after 6 months, continues observation 2 months after cured person drug withdrawal.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Criterion of therapeutical effect is drafted with reference to " new Chinese medicine guideline of clinical investigations ":
Effective: transference cure after treatment, or integration decline >=2 grades;
Effective: after treatment, symptom integral declines a grade and not disappearing;
Invalid: the rear symptom for the treatment of is unchanged or increase the weight of.
Effectively total=effective+effectively.
3.3 therapeutic outcome
Table 4 liang group Clinical efficacy comparison
| Group | Obvious effective rate (%) | Effective percentage (%) | Inefficiency (%) | Total effective rate (%) |
| Treatment group | 26(74.3%) | 7(20%) | 1(2.9%) | 34(97.1%) |
| Matched group | 20(58.8%) | 11(32.4%) | 2(5.9%) | 32(94.1%) |
It is high that visible the present invention is used for the treatment of hyperthyroidism cure rate, has the value applied.
The analysis of 3.4 liang of group safety observations
Every 2 weekly checks of experimenter also record routine blood test l time, and check per January and record liver function 1 time, untoward reaction is record at any time.By entering to organize the observation of patient's routine blood test of 6 months, liver function and untoward reaction to 69 examples, draw to draw a conclusion.Treatment group only has 1 example to occur slight leukopenia abnormal (i.e. WBC > 3.0 × 109), 1 routine abnormal liver function (i.e. ALT < 80U/L, AST < 80U/L), without other untoward reaction, overall adverse reaction rate is 5.7%.Matched group has 4 examples to occur leukopenia exception, and slight abnormal liver function appears in 2 examples, and do not find other untoward reaction such as erythra, overall adverse reaction rate is 17.6%.Give anti symptom treatment respectively, wherein leukopenia person gives leucogen 10mg, and three times on the one oral, DIYU SHENGBAI PIAN 20mg, and three times on the one oral; Abnormal liver function person gives Inosine tablets 0.2g, and three times on the one oral.Supervise is observed display patient biochemical analysis and is all recovered normal.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: Spica Prunellae 7 grams, Rhizoma Dioscoreae Bulbiferae 6 grams, Radix Gentianae 2 grams, Pseudobulbus Cremastrae Seu Pleiones 5 grams, Radix Scrophulariae 13 grams, Sinomenium acutum 12 grams, Thallus Laminariae (Thallus Eckloniae) 13 grams, Radix Angelicae Pubescentis 4 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of hyperthyroidism.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: Spica Prunellae 7 grams, Rhizoma Dioscoreae Bulbiferae 6 grams, Radix Gentianae 2 grams, Pseudobulbus Cremastrae Seu Pleiones 5 grams, Radix Scrophulariae 13 grams, Sinomenium acutum 12 grams, Thallus Laminariae (Thallus Eckloniae) 13 grams, Radix Angelicae Pubescentis 4 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of hyperthyroidism.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 3
Take: Spica Prunellae 7 grams, Rhizoma Dioscoreae Bulbiferae 6 grams, Radix Gentianae 2 grams, Pseudobulbus Cremastrae Seu Pleiones 5 grams, Radix Scrophulariae 13 grams, Sinomenium acutum 12 grams, Thallus Laminariae (Thallus Eckloniae) 13 grams, Radix Angelicae Pubescentis 4 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of hyperthyroidism.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. one kind is used for the treatment of hyperthyroid Chinese medicine, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts.
2. be used for the treatment of hyperthyroid Chinese medicine as claimed in claim 1, it is characterized in that, its preparation method is: take: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. be used for the treatment of hyperthyroid Chinese medicine as claimed in claim 1, it is characterized in that, its preparation method is: take: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. be used for the treatment of hyperthyroid Chinese medicine as claimed in claim 1, it is characterized in that, its preparation method is: take: Spica Prunellae 7 parts, Rhizoma Dioscoreae Bulbiferae 6 parts, Radix Gentianae 2 parts, Pseudobulbus Cremastrae Seu Pleiones 5 parts, Radix Scrophulariae 13 parts, Sinomenium acutum 12 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Radix Angelicae Pubescentis 4 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105582302A (en) * | 2016-03-11 | 2016-05-18 | 黄国华 | Medicine for treating chronic adrenocortical hypofunction |
| CN105687740A (en) * | 2016-03-11 | 2016-06-22 | 黄国华 | Drug for treating chronic lymphocytic thyroiditis |
| CN113633746A (en) * | 2021-09-28 | 2021-11-12 | 浙江养和健康管理科技有限公司 | Composition for treating thyroid diseases and preparation method thereof |
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| CN101890125A (en) * | 2009-05-21 | 2010-11-24 | 中国中医科学院广安门医院 | Medicament for treating hyperthyroidism and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105582302A (en) * | 2016-03-11 | 2016-05-18 | 黄国华 | Medicine for treating chronic adrenocortical hypofunction |
| CN105687740A (en) * | 2016-03-11 | 2016-06-22 | 黄国华 | Drug for treating chronic lymphocytic thyroiditis |
| CN113633746A (en) * | 2021-09-28 | 2021-11-12 | 浙江养和健康管理科技有限公司 | Composition for treating thyroid diseases and preparation method thereof |
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Application publication date: 20150121 |