CN104906400A - Traditional Chinese medicine for treating acute cerebral ischemic stroke - Google Patents
Traditional Chinese medicine for treating acute cerebral ischemic stroke Download PDFInfo
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- CN104906400A CN104906400A CN201510372468.8A CN201510372468A CN104906400A CN 104906400 A CN104906400 A CN 104906400A CN 201510372468 A CN201510372468 A CN 201510372468A CN 104906400 A CN104906400 A CN 104906400A
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Abstract
The invention relates to a traditional Chinese medicine for treating acute cerebral ischemic stroke. The traditional Chinese medicine is prepared from the following raw medicinal materials in parts by weight: 12 parts of stem of Chinese starjasmine, 6 parts of root of largeleaf gentian, 3 parts of arisaema with bile, 11 parts of suberect spatholobus stem, 5 parts of tall gastrodia tuber, 14 parts of dioscorea spongiosa and 9 parts of common clubmoss herb. A clinical experiment proves that the traditional Chinese medicine provided by the invention can be used for safely and effectively treating the acute cerebral ischemic stroke.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of acute ischemic stroke.
Background technology
Apoplexy is because cerebrovascular disease causes sudden local cerebral functional impairment, is broadly divided into ischemic and the large class of hemorrhagic two.Ischemic mainly contains thrombotic and embolic two kinds, is caused by vasospasm or cerebroma vascular compression once in a while.Thrombotic is that cerebrovascular wall makes lumen of vessels more and more little because atherosclerotic sample changes, even total blockage; Embolic is occur an object (embolus) suddenly in blood vessel, is stuck in the less blood vessel of bore, has blocked passing through of blood with blood flow.As for its omen, because cerebral tissue is after shortage blood flow is filled with, its function can be lost very rapidly, and produce so-called nervus centralis disease.The sick category such as apoplexy, apoplexy, syndrome similar to wind disease, hemiplegia, hemiplegia belonging to Chinese medicine, apoplexy is the four large difficult diseases " wind consumptive disease bone diaphragm " that ancient literature one is recorded, one of, because primary disease morbidity is unexpected, onset is hurried, with the feature similarity of nature " characteristic of wind being apt to move in frequent change ", therefore ancient medicine classification according to manifestation and name is " apoplexy "; Again because its morbidity is unexpected, be also referred to as " apoplexy ".Comprehensive ancient Chinese medicine doctor discussed, the etiology and pathogenesis of apoplexy, and not outer is wind, fire, expectorant, void, gas, blood six end.But the basic pathogenesis of apoplexy is familiar with, each doctor has different viewpoints.Clinically, apoplexy is complicated and changeable, and ancient Chinese medicine doctor thinks that its pathogenesis mainly contains: deficiency of vital energy blood is tired, expectorant tired resistance network, heart-fire is cruelly high, internal injury is deficient, phlegm-heat accumulation etc., and never ipsilateral illustrates the place of Acute Stroke pathogenesis.
Medical material present Research involved in the present invention is as follows:
Caulis Trachelospermi [another name] stone dace, alum, outstanding stone, Yun Zhu, sea urchin roe paste, stone are consulted, slightly stone, neck stone, SHILONG rattan, resistance to winter, stone blood, the red Caulis Trachelospermi of Radix Clematidis terniflorae, the leaf bine stem that is apocynaceae plant trachelospermum jasminoide to leaf rattan, Caulis et Folium piperis, GUOQIANGFENG, parthenocissus, Shi Bangteng, tiger of sitting on the fence, Radix seu Caulis fici Martinii [source].To plant after 3 ~ 4 years autumn Mo clip rattan, be cut into 25 ~ 30cm long, be bundled into wisp, dry.[nature and flavor] are bitter; Pungent; Cold nature.[return through] heart; Liver; Kidney channel.[function cures mainly] removing obstruction in the collateral to relieve pain; Heat clearing and blood cooling; Removing toxic substances and promoting subsidence of swelling.Main air pain of dampness syndrome; Soreness of waist and knee joint; The contracture of muscle arteries and veins; Laryngopharynx swelling and pain; Furuncle swelling toxin; Traumatic injury; Traumatic hemorrhage.[usage and dosage] takes orally: decoct field, and 6 ~ 15g single can with to 30g; Infusing drugs in wine, 30-60g; Or enter ball, powder.External: appropriate, grinds into powder and dresses or smash juice painting.[extracts] " China's book on Chinese herbal medicine "
Radix Gentianae Macrophyllae [another name] Qin glue, Qin's letter, the Qin entangle, Qin's pawl, RADIX GENTIANAE MACROPHYLLAE, Radix Gentianae Marcrophyllae, Zuo Ninggen, a left side are turned round, western Radix Gentianae Marcrophyllae, RADIX GENTIANAE MACROPHYLLAE, Radix Raphani Macrophylla, lobe Macrophylla, drumsticks Macrophylla, mountain Radix Gentianae Marcrophyllae, Qu Shuan [source] are gentianaceae plant Radix Gentianae Macrophyllae, the root of gentiana crassicaulis Duthie, gentiana straminea, Da Wuli Radix Gentianae Macrophyllae.Within after planting 3 ~ 5 years, gather.Spring, autumn all can excavate, but better with quality in autumn.Remove stem and leaf after digging out, shine to time soft, pile in heaps, nature is generated heat, when becoming flesh pink to root inside, dry.Also after uprooting, directly can dry.Da Wuli Radix Gentianae Macrophyllae washes away silt after uprooting, and rubs de-black skin with the hands, dries.[nature and flavor] are bitter; Pungent; Be slightly cold.[return through] stomach; Liver; Gallbladder meridian.[function cures mainly] wind-damp dispelling; Relaxing muscles and tendons network; Clearind deficient heat; Dampness removing jaundice eliminating.The logical pain of main air arthralgia chiefly caused by damp pathogen; Muscles and bones contracture; Hands and feet caused by paralysis; Osteopyrexia and fever; Children's's infantile malnutrition with fever; Jaundice due to damp-heat.[usage and dosage] takes orally: decoct soup, 5-10g; Or infusing drugs in wine; Or enter ball, loose.External: appropriate, grinds into powder and spreads.[extracts] " China's book on Chinese herbal medicine "
Processed goods [nature and flavor] bitter in the mouth that Arisaema Cum Bile [another name] Arisaema Cum Bile [source] is made through fermentation for Rhizoma Arisaematis (processed) fine powder and cattle, sheep or Fel Sus domestica mixing or Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica; Micro-pungent; Cool in nature.[return through] liver; Gallbladder; Lung meridian.[function cures mainly] clearing away fire and eliminating phlegm; Relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Main apoplexy; Infantile convulsion; Epilepsy; Headache; Dizzy; Breathe heavily and cough.[usage and dosage] takes orally: decoct soup, 3-6g; Or enter ball, loose.[extracts] " China's book on Chinese herbal medicine "
Caulis Spatholobi [another name] Radix seu Caulis Verntilaginis Leiocarpae, Cervus elaphus linnaeus rattan, lac encrusted twig rattan, Sanguis sus domestica rattan, nine layers of wind, Caulis Sargentodoxae, HUOXUETENG, Caulis Sargentodoxae, blood dragon rattan, Caulis Bauhihiae Championii, five layers of blood.[source] is the rattan of leguminous plant spatholobus suberectus.Gather autumn ratan, removing branch and leaf, the section of being sawn into, dries.Or cut into slices time fresh, dry.[nature and flavor] bitter in the mouth; Micro-sweet; Warm in nature.[return through] heart; Spleen channel.[function cures mainly] relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.[usage and dosage] takes orally: decoct soup, 10-15g, heavy dose of available to 30g; Or infusing drugs in wine.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Gastrodiae [another name] rhizoma gastrodiae, from mother, yellow moccasin flower, SHENCAO, solely shake sesame, rhizoma gastrodiae fat, DINGFENGCAO, conjunction from grass, solely shake, automatic grass, water Rhizoma Solani tuber osi [source] tuber that is orchid Rhizoma Gastrodiae.The 2nd year winter that winter plants or the 3rd year spring excavate; Spring plant winter then or the 2nd year spring excavate, first get bacterium material during results, after get Rhizoma Gastrodiae, arrow fiber crops make medicine, hemp and rice fiber crops plant.To process in time after results, take advantage of and freshly first remove silt particle, be graded by sized, decocting in water, the large Rhizoma Gastrodiae of more than 150g, boil 10-15min, 100-150g person boils 7-10min, and below 100g person boils 5-8min, Deng outside boil 5min, so that thoroughly for degree, chimney kiln can be put into after cooked by the heart, smoke 20-30min with sulfur, rear slow fire baking, on a heatable brick bed, temperature starts to be advisable with 50-60 DEG C, when becoming dry to 7-8, taking-up hand is flat, a heatable brick bed in continuation, now temperature at about 70 DEG C, after Rhizoma Gastrodiae is absolutely dry, should go out a heatable brick bed immediately.[nature and flavor] are sweet; Pungent; Flat; Nontoxic.[return through] liver; Spleen; Kidney; Gallbladder; The heart; Urinary bladder channel.[function cures mainly] endogenous wind stopping relieving convulsion; Suppressing the hyperactive liver sun; Dispelling wind and removing obstruction in the collateral.Main anxious chronic infantile convulsion; Tic contracture; Dizzy; Headache; Hemiplegia; Limb fiber crops; Rheumatic arthralgia.[usage and dosage] takes orally: decoct soup, 3-10g; Or enter ball, fall apart, grind into powder and swallow, each 1-1.5g.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Dioscoreae Septemlobae [another name] dustpan bucket, mountain dustpan, mountain potato, Canis familiaris L. excrement, great Rhizoma Dioscoreae Septemlobae [source] this product are the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Septemlobae or Foochow Rhizoma Dioscoreae.Autumn, season in winter one excavate, and removing fibrous root, cleans, and section, dries.Put aeration-drying place.[nature and flavor] are bitter; Pungent; Flat.[function cures mainly] wind-damp dispelling; Dampness removing is turbid; Detumescence poison.Main air pain of dampness syndrome; Soreness of waist and knee joint; Turbid urine; Drench drop; Leucorrhea.[usage and dosage] takes orally: decoct soup, 9-20g; Or infusing drugs in wine; Or enter ball=loose.External: appropriate, fresh goods is smash deposited.[extracts] " China's book on Chinese herbal medicine "
Herba Lycopodii [another name] Lycopodium clavatum, Cortex Ampelopsis Aconitifoliae Radicis, Herba Lycopodii, Linesless charcoal Pueraria lobota, golden hair lion grass, Flos Wikstroemiae Nutantis, lion grass [source] this product are the herb of lycopsid Lycopodium clavatum, L. centro-chineseChing and Fructus Seu Herba Pubescentis.Summer gathers, and uproops, and removes earth, impurity, dries.[nature and flavor] are bitter; Pungent; Temperature; Nontoxic; Flat [return through] liver; Spleen; Kidney channel.[function cures mainly] expelling wind and cold; Dehumidifying detumescence; Relaxing muscles and tendons to promote blood circulation; Cough-relieving; Removing toxic substances.Main anemofrigid-damp arthralgia; Joint aches; Skin numbness; Tetraparesis; Edema; Traumatic injury; Jaundice; Cough; Skin infection; Herpes; Scald.[usage and dosage] takes orally: decoct soup, 9-15g; Or infusing drugs in wine.External: appropriate, smashes deposited.[extracts] " China's book on Chinese herbal medicine "
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of acute ischemic stroke, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing acute ischemic stroke.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a Chinese medicine for acute ischemic stroke, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Caulis Trachelospermi 12 parts, Radix Gentianae Macrophyllae 6 parts, Arisaema Cum Bile 3 parts, Caulis Spatholobi 11 parts, 5 parts, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 parts, Herba Lycopodii 9 parts.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects Acute Ischemic Stroke Patients 88 example of outpatient clinic altogether between in May ,-2013 in April, 2011, all meet acute ischemic stroke diagnostic criteria.All patients are divided at random treatment group 44 example and matched group 44 example.Two groups of aspects such as patient age, sex compare in Table 1-table 2.
Table 1 liang group patient age (year) compare
Table 2 liang group gender comparison
Compare P by the visible two groups of patient's basic documents of table 1-table 2 and be all greater than 0.05, namely two groups of patient clinical basic document there was no significant differences, have comparability.
1.2 diagnostic criteria
" TCM diagnosis efficacy assessment standard " with reference to Society of Internal Medicine of All-China Association of Traditional Chinese Medicine revision in 1986:
Primary symptom: hemiplegia, crooked mouth and tongue, mind unconsciousness, hemianesthesia.
Acute onset.
Sick sending out has inducement more, often has premonitory symptom before not sending out.
Send out well the age many more than 40 years old.
Have primary symptom two or more, acute stadium, the feature in conjunction with aspects such as tongue, arteries and veins, inducement, tendency, ages can determine diagnosis.
2, test method
2.1 Therapeutic Method
The decoct that the oral the present invention for the treatment of group obtains according to specific embodiment 1, every day 3 times, 2 weeks/course for the treatment of.
The oral troxerutin of matched group, uses according to its description, 2 weeks/course for the treatment of.
Treatment group group and matched group case all give acute ischemic stroke diet.
Duration of test all experimenters forbidding is to the medicative Chinese and western drugs of acute ischemic stroke tool and other Therapeutic Method, run into merging disease and must take other drug treatment, the information such as medicine name (comprising trade name and chemical name), consumption, Slurry pump, access times and time must be recorded in case report form, analyzed during summary and report.
Treat two courses for the treatment of (4 weeks) and add up two groups of two groups of clinical total effectses afterwards
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
3.1.1 observation index
(1) tcm symptom total mark
The project meeting this research observation is selected according to " acute ischemic stroke Syndrome Scale quantization table " in 2000 editions " new Chinese medicine guideline of clinical investigations ", make acute ischemic stroke tcm symptom scalar quantization table (see table 3), mark according to scale content, every symptom is added and obtains total mark, evaluate the change of symptom assessment total mark before and after treatment.
Table 3 acute ischemic stroke tcm symptom scalar quantization table
3.1.2 clinical total effects criterion
With reference to acute ischemic stroke efficacy assessment standard in " new Chinese medicine guideline of clinical investigations " (2002).
Full marks 28 points before treatment, minimum point of starting point is not less than 18 points, and efficacy evaluation adopts nimodipine method, i.e. integration * 100% before (after the front integration-treatment for the treatment of integration)/treatment
(1) clinical recovery: >=85%;
(2) effective: >=50%:
(3) effective: >=20%;
(4) invalid: less than 20%.
Total effective rate=(effective+effectively)/total number of cases * 100%
3.2 therapeutic outcome
3.2.1 tcm symptom total mark changes
Before and after treatment group treatment, comparing difference has statistical significance (the interior paired t-test of group, P < 0.05), and namely treatment group traditional Chinese medical science total mark significantly reduces.Before and after treatment of control group, comparing difference has statistical significance (the interior paired t-test of group, P < 0.05), and namely matched group traditional Chinese medical science total mark also significantly reduces.Treatment group compares with matched group, and difference has statistical significance (comparing between group, independent samples t-test, P < 0.05), and namely the curative effect for the treatment of group is better than matched group.Concrete outcome is in table 4.
Tcm symptom total mark before and after table 4 liang group patient treatment
3.2.3 two groups of clinical total effectses
Two groups of tcm syndrome comparitive study after treatment in 4 weeks, specifically in table 5.
The table 5 liang clinical total effects of group compares
Be used for the treatment of acute ischemic stroke cure rate by the visible the present invention of above result high, there is the value applied.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: Caulis Trachelospermi 12 grams, Radix Gentianae Macrophyllae 6 grams, Arisaema Cum Bile 3 grams, Caulis Spatholobi 11 grams, 5 grams, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 grams, Herba Lycopodii 9 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of acute ischemic stroke.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: Caulis Trachelospermi 12 grams, Radix Gentianae Macrophyllae 6 grams, Arisaema Cum Bile 3 grams, Caulis Spatholobi 11 grams, 5 grams, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 grams, Herba Lycopodii 9 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of acute ischemic stroke.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 3
Take: Caulis Trachelospermi 12 grams, Radix Gentianae Macrophyllae 6 grams, Arisaema Cum Bile 3 grams, Caulis Spatholobi 11 grams, 5 grams, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 grams, Herba Lycopodii 9 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of acute ischemic stroke.Oral, every bu morning, noon and afternoon take for three times.
Claims (4)
1. be used for the treatment of a Chinese medicine for acute ischemic stroke, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Caulis Trachelospermi 12 parts, Radix Gentianae Macrophyllae 6 parts, Arisaema Cum Bile 3 parts, Caulis Spatholobi 11 parts, 5 parts, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 parts, Herba Lycopodii 9 parts.
2. a kind of Chinese medicine being used for the treatment of acute ischemic stroke as claimed in claim 1, it is characterized in that, its preparation method is: take: Caulis Trachelospermi 12 parts, Radix Gentianae Macrophyllae 6 parts, Arisaema Cum Bile 3 parts, Caulis Spatholobi 11 parts, 5 parts, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 parts, Herba Lycopodii 9 parts; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of Chinese medicine being used for the treatment of acute ischemic stroke as claimed in claim 1, it is characterized in that, its preparation method is: take: Caulis Trachelospermi 12 parts, Radix Gentianae Macrophyllae 6 parts, Arisaema Cum Bile 3 parts, Caulis Spatholobi 11 parts, 5 parts, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 parts, Herba Lycopodii 9 parts; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
4. a kind of Chinese medicine being used for the treatment of acute ischemic stroke as claimed in claim 1, it is characterized in that, its preparation method is: take: Caulis Trachelospermi 12 parts, Radix Gentianae Macrophyllae 6 parts, Arisaema Cum Bile 3 parts, Caulis Spatholobi 11 parts, 5 parts, Rhizoma Gastrodiae, Rhizoma Dioscoreae Septemlobae 14 parts, Herba Lycopodii 9 parts; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, obtains capsule; Above-mentioned part all refers to weight portion.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748779A (en) * | 2016-03-23 | 2016-07-13 | 陆茹姣 | Medicine for treating ischemic stroke |
| CN106109675A (en) * | 2016-08-09 | 2016-11-16 | 石本奖 | A kind of Miao Ethnomedicine treating cerebral thrombosis |
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| JPH11302174A (en) * | 1998-04-23 | 1999-11-02 | Maruho Co Ltd | Cell adhesion inhibitor |
| CN1943726A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of ischemic apoplexy and its preparation method |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11302174A (en) * | 1998-04-23 | 1999-11-02 | Maruho Co Ltd | Cell adhesion inhibitor |
| CN1943726A (en) * | 2005-10-08 | 2007-04-11 | 周小明 | A Chinese traditional medicinal composition for treatment of ischemic apoplexy and its preparation method |
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| 司长源: "《内科疾病的现代诊断与治疗》", 28 February 2006 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748779A (en) * | 2016-03-23 | 2016-07-13 | 陆茹姣 | Medicine for treating ischemic stroke |
| CN106109675A (en) * | 2016-08-09 | 2016-11-16 | 石本奖 | A kind of Miao Ethnomedicine treating cerebral thrombosis |
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Application publication date: 20150916 |