CN101380414B - Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof Download PDFInfo
- Publication number
- CN101380414B CN101380414B CN2007100300970A CN200710030097A CN101380414B CN 101380414 B CN101380414 B CN 101380414B CN 2007100300970 A CN2007100300970 A CN 2007100300970A CN 200710030097 A CN200710030097 A CN 200710030097A CN 101380414 B CN101380414 B CN 101380414B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- hyperuricemia
- hour
- medicine composition
- gout
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 49
- 201000005569 Gout Diseases 0.000 title claims abstract description 42
- 201000001431 Hyperuricemia Diseases 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims description 24
- 238000002360 preparation method Methods 0.000 title abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 14
- 239000012141 concentrate Substances 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000002775 capsule Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 8
- 238000012856 packing Methods 0.000 claims description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- -1 decoction Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 18
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract description 17
- 210000004369 blood Anatomy 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 16
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract description 13
- 229940116269 uric acid Drugs 0.000 abstract description 13
- 244000052769 pathogen Species 0.000 abstract description 5
- 230000001717 pathogenic effect Effects 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 230000029142 excretion Effects 0.000 abstract description 3
- 230000000144 pharmacologic effect Effects 0.000 abstract description 3
- 208000004880 Polyuria Diseases 0.000 abstract description 2
- 230000035619 diuresis Effects 0.000 abstract description 2
- 238000009825 accumulation Methods 0.000 abstract 1
- 208000006820 Arthralgia Diseases 0.000 description 7
- 230000001154 acute effect Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 6
- 230000001684 chronic effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 206010018634 Gouty Arthritis Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 235000004443 Ricinus communis Nutrition 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 229960001338 colchicine Drugs 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000001788 irregular Effects 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 208000004930 Fatty Liver Diseases 0.000 description 2
- 206010019708 Hepatic steatosis Diseases 0.000 description 2
- 208000000913 Kidney Calculi Diseases 0.000 description 2
- 206010029148 Nephrolithiasis Diseases 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 201000005577 familial hyperlipidemia Diseases 0.000 description 2
- 208000010706 fatty liver disease Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 241000234272 Dioscoreaceae Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241001057584 Myrrha Species 0.000 description 1
- 208000008558 Osteophyte Diseases 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 1
- 229960003459 allopurinol Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002961 anti-hyperuricemic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- WHQCHUCQKNIQEC-UHFFFAOYSA-N benzbromarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(Br)=C(O)C(Br)=C1 WHQCHUCQKNIQEC-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229940084627 colchicine 0.5 mg Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000004144 purine metabolism Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 239000010382 simiaowan Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000020990 white meat Nutrition 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a traditional Chinese medicine preparation for treating gout and hyperuricemia and a preparation method thereof. The Chinese medicinal preparation has effects of removing dampness, removing turbid pathogen, removing blood stasis, dredging collaterals, promoting diuresis and not damaging yin, and is especially used for gout and hyperuricemia caused by damp turbidity accumulation. The traditional Chinese medicine preparation provided by the invention has the pharmacological effects of remarkably reducing blood uric acid and accelerating excretion of uric acid.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of treating gout and hyperuricemia and preparation method thereof, be specifically a kind of be the treatment gout processed of raw material and pure Chinese medicinal preparation of hyperuricemia and preparation method thereof with the natural Chinese medicinal herb.
Background technology
From the viewpoint of the traditional Chinese medical science, gout and hyperuricemia, the category of genus " arthromyodynia " is a common clinical, frequently-occurring disease.The traditional Chinese medical science to primary disease understanding early, medical secrets of official " calls its pyretic toxicity gas and from internal organs, go out, and people's vital organs of the human body Jing Xing is defeated, all refers to from brothers, so poison is attacked in brothers also from interior and go out." gout is divided into acute stage and catabasis.Modern Chinese medicine thinks that too much uric acid belongs to turbid, the turbid damp of expectorant, and the main cause of gout is dysfunction of the spleen in transportation or innate deficiency, spleen the clear failing to ascend and the turbid failing to descend so that endogenous damp formation; Hold concurrently again excessive drinking gluttony, overstrain can impel then that the expectorant turbidity current is annotated in the joint, muscle, and it is local red and swollen scorching hot to cause QI-blood circulation freely not cause; Arthralgia forms arthromyodynia unbearably; Its pathogenesis is turbid damp numbness resistance meridians, the stasis of blood and heat-transformation, stagnation of QI and blood may bring about pain.Acute stage, show as gouty arthritis, and the arthromyodynia protracted course of disease gets into the relative remission phase, and except that the pain due to damp and hot turbid pathogen impatency meridians are arranged, the symptom of YIN fluid deficiency also often appears in the damp and hot turbid pathogen cloudy Tianjin of burning.Reinforcement can effectively prevent the incidence and development of gout to the control of hyperuricemia, has embodied the importance of traditional Chinese medical science preventive treatment of disease.
From the viewpoint of doctor trained in Western medicine, gout is the heterogeneous chronic metabolic disease of a group due to the purine metabolism obstacle, is divided into two types of constitutional and Secondary cases, mainly shows as acute gouty arthritis, intermission and chronic arthritis clinically.The acute attack of gout is that urate is in the joint and the acute inflammatory reaction that causes with crystal form deposition of joint surrounding tissue.But the gout outbreak continues natural remission a couple of days to several weeks, and joint motion can recover fully, i.e. the so-called intermission.If gout is untreated, and urate increases in the intraarticular deposition, the inflammation entering chronic phase that shows effect repeatedly.
In treatment, the medicine of doctor trained in Western medicine colchicine commonly used, NSAID and inhibition uricopoiesis is handled the gout patient at present, and curative effect is pretty good basically, but the side effect of allergic constitution and gastrointestinal upset is rather common.And the traditional Chinese medical science also has many side's medicines can treat gout and hyperuricemia; Can select for use Radix Angelicae Sinensis to pick up pain soup, Baihu Jia Guizhi Tang, SIMIAO WAN, clear numbness Medicine wine for activating the channels according to the state of an illness, compound recipe is stretched muscle capsule, wrinkle kidney analgesic therapy capsule etc.; Dialectical application can obtain certain curative effect; But the raw material numerous and complicated is expensive and curative effect is still not ideal enough.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition of treating gout and hyperuricemia.
Another object of the present invention provides the method for preparing of a kind of treatment gout and antihyperuricemic Chinese medicine composition.
Chinese medicine composition of the present invention is that You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati are processed.
Chinese medicine composition of the present invention has the dampness removing not effect of impairment of YIN of turbid, disperse blood stasis and dredge collateral, dampness removing of dispelling, and is mainly used in treatment gout and hyperuricemia, and the traditional Chinese medical science is distinguished to turbid damp and pented up pattern of syndrome.Chinese medicine composition of the present invention has remarkable reduction blood uric acid, quickens the pharmacological action of urate excretion.
The method for preparing of Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 15-45
Rhizoma Polygonati Odorati 6-15
Radix Achyranthis Bidentatae 6-15
The method for preparing of preferred Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 15-45
Rhizoma Polygonati Odorati 6-15
Radix Achyranthis Bidentatae 6-15
The method for preparing of further preferred Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 30-50
Rhizoma Polygonati Odorati 15-30
Radix Achyranthis Bidentatae 10-15
The method for preparing of best Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 45
Rhizoma Polygonati Odorati 15
Radix Achyranthis Bidentatae 10
A kind of Chinese medicine composition of treating gout and hyperuricemia of the present invention, it can process various dosage forms by conventional method, comprises oral liquid, capsule, pill, decoction, tablet, soft capsule, granule, powder etc.
In various dosage forms, preferred a kind of oral liquid of processing by following method, this method for preparing is:
A adds 3-6 times of water gaging Jiang Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati and decocts twice, and 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B filters, merging filtrate, and concentrate, added the 50-60% soak with ethanol 10-15 hour, filter, reclaim ethanol, add water to aequum; And add a certain amount of antiseptic;
C is distributed into finished product.
Concrete instructions of taking and consumption: oral, every day 2 times, each 15ml, 7 days acute stages were a course of treatment, one month chronic phase was a course of treatment.
In various dosage forms, also preferred a kind of capsule of processing by following method, this method for preparing is:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 3-6 times of water gaging and boil, extract 2 times, and 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B filters, and merges filtrating 2 times, concentrates;
C added the 50-60% soak with ethanol 10-15 hour, filtered, and reclaimed ethanol, and filtrating concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides in the capsule shells of packing into, finished product.
The Chinese medicine of respectively distinguishing the flavor of in the Chinese medicine preparation of the present invention is crude drug.Rhizoma Dioscoreae Septemlobae in the side is perennial draft plant cotton Rhizoma Dioscoreae Septemlobae and the powder back of the body Rhizoma Dioscoreae rhizome of overgrowing of Dioscoreaceae.The little suffering of bitter in the mouth, cold nature is nontoxic.Have dampness removing and go turbidly, blood stasis dispelling dispels the wind.Modern pharmacological research finds that Rhizoma Dioscoreae Septemlobae has remarkable reduction blood uric acid, quickens the function of urate excretion.Powder castor seed, soil Fu alias thorn, white meat dog bone spurs, roots will occur, near the ground, bamboo-like leaves are alternate, triangular-ovate or ovate-lanceolate, leaf dry nearly black, flowers unisexual, dioecious male inflorescence spike-like, was born in the hillside forest, medicinal roots and more into irregular flakes, sizes, irregular edges, some with dark brown or gray-brown rind, cut yellowish-white or grayish brown, flat, There are pink sex, quality pine, slightly elastic, easily broken; Mian castor seed, castor seed alias soft roots of plant, hillslopes bushes, medicinal roots mostly irregular oblique slices, sizes, skin yellow-brown or brown, surrounding curly, sparse root base conical protrusion marks, cut off-white or yellowish-white, yellow-brown visible tendons point spread in vascular bundles, quality pine, slightly spongy.
A kind of Chinese medicine preparation of treating gout and hyperuricemia of the present invention is to be prepared from three kinds of Chinese herbal medicine; Its prescription science, rationally, concertedness is good; The specially good effect side that belongs to treatment gout and hyperuricemia; The curative effect highly significant, shortcoming such as it is many to have overcome existing prescription flavour of a drug, and complex process, curative effect are not significantly, side effect is many.
Below further specify the drug action that the present invention treats gout and hyperuricemia through clinical trial:
A method: adopt Chinese medicine from intending gout soup! Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae, Rhizoma Polygonati Odorati) treatment gout 50 examples, and establish matched group (the Western medicine colchicine is treated gout with NSAID) 48 examples and compare.
Result: treatment group total effective rate 96.0%; Matched group total effective rate 85.4%,
Through statistical procedures, difference has highly significant property meaning (P＜0.01).
Prompting: this method has dehumidifying row turbid to primary disease, the effect of promoting blood circulation and detumescence pain relieving, removing dampness and non-impairment of YIN.
Specific as follows:
Clinical data is observed case and is No.1 Hospital Affiliated to Zhongshan Univ.'s traditional Chinese medical science rheumatism training and was in hospital in 2005 and out-patient's totally 94 examples, and employing digital watch method is divided into two groups at random.50 examples are organized in treatment, male's 45 examples, women's 5 examples, age 22-72 year, average 42.5 years old, course of disease 2d～25 year, average 3.93 years.Overweight people's 37 examples.Heating person's 11 examples before the treatment, fast 21 examples of erythrocyte sedimentation rate, blood uric acid increases 50 examples, leukocyte 19 examples that raise, hyperlipemia 25 examples, B ultrasonic: renal calculus 13 examples, fatty liver 14 examples; Matched group 48 examples, male 40 examples, women 8 examples, 25～71 years old age, average 41.3 years old, course of disease 1d～21 year, average 2.6 years.Overweight people's 30 examples.Heating person's 10 examples before the treatment, fast 9 examples of erythrocyte sedimentation rate, blood uric acid increases 48 examples, leukocyte 10 examples that raise, hyperlipemia 19 examples, B ultrasonic: renal calculus 6 examples, fatty liver 11 examples.2 groups of clinical datas relatively, and are roughly the same, have comparability.Diagnostic criteria certificate American Rheumatism Association in 1997 is about the acute gouty arthritis criteria for classification.The differentiation of symptoms and signs for classification of syndrome pyretic arthralgia: the redness and swelling of joints burning pain, it is thirsty to generate heat, red tongue with yellow fur, slippery and rapid pulse.Arthralgia due to cold: arthralgia is miserable, or the enlargement distortion, meets cold increasing the weight of, or tophus, or ulceration stream white paste, and tongue is greasy in vain, stringy and tense pulse.
Therapeutic Method treatment group: basic side forms: Rhizoma Dioscoreae Septemlobae 30g, Radix Achyranthis Bidentatae 15g, Rhizoma Polygonati Odorati 15g.Plus-minus: heating adds Flos Lonicerae, Gypsum Fibrosum, and redness adds Rhizoma Atractylodis, Cortex Phellodendri, and the pain play adds Olibanum (processed) and Myrrha, and arthralgia due to cold adds Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata, and lithangiuria adds Talcum, Endothelium Corneum Gigeriae Galli, has tophus to add Rhizoma Arisaematis, the Radix Angelicae Dahuricae.Usage: 1 dose of every day, decocting 2 times, decoction being taken warmly sooner or later; Matched group: colchicine 0.5mg, 1 day 2 times, or add NSAID or hormone, chronic phase, can according to circumstances be selected the uric acid resisting medicine for use.2 groups was 1 course of treatment with treatment 7d all, finished the statistics therapeutic outcome 2～5 courses of treatment.
The criterion of therapeutical effect clinical cure: arthralgia disappears, and uric acid content is normal in blood and the urine, follows up a case by regular visits to 2 years not recidivists.Produce effects: arthralgia alleviates, and uric acid content obviously reduces in blood and the urine.Invalid; No change before and after the treatment.
2 groups of clinical cure rates of therapeutic outcome are (P＜0.01) relatively, and difference has the highly significant meaning, and the treatment group obviously is superior to matched group.
It is that its pathogenesis basis is a hyperuricemia owing to purine metabolic disturbance causes one group of not normal disease of uric acid metabolism that gout is discussed.Many the controlling inflammation with colchicine and NSAID or hormone of Western medicine shown effect to improve symptom in the treatment; Adopt allopurinol; Uric acid reducing such as narcaricin still lack the radical cure measure with uric acid reducing, in case the drug withdrawal state of an illness easily repeatedly; And the said medicine side effect is all bigger, has increased the difficulty of prolonged application.The utilization tcm syndrome differentiation and treatment, the phlegm-damp turbid pathogen is able to get rid of external, and is hot and suffocating clearly, and environment tends to balance in making, and hyperuricemia is able to remove and disease is fully recovered.This this research treatment by Chinese herbs gout is different from traditional arthromyodynia Coryza Treated by Syndrome Differentiation, and tradition thinks that the many damp and hot evil numbness resistance joint stasis of blood choke blood of exopathogen or interior life that wait because of wind and cold is damp and hot of primary disease fall ill.The rule of treatment is with clearing away heat-damp and promoting diuresis, and expelling wind and cold, blood circulation promoting and blood stasis dispelling are main.And our clinical observation finds that the turbid damp pathogen accumulates body for a long time, the stasis of blood and heat-transformation, refining Tianjin liquid that burns, numbness resistance meridians and cause gout.So treatment on dampness removing is dispelled turbid basis, add Rhizoma Polygonati Odorati with YIN nourishing, Radix Achyranthis Bidentatae with blood circulation promoting and blood stasis dispelling, that tests is clinical, can obviously reduce hyperuricemia and improve symptom, side effect is little, but longer-term is used.
The specific embodiment
Below adopt embodiment to specify a kind of Chinese medicine preparation of treating gout and hyperuricemia of the present invention and preparation method thereof.
Embodiment 1
A kind of oral liquid of treating gout, it is prepared from by following weight portion proportioning Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 450 grams
Radix Achyranthis Bidentatae 225 grams
Rhizoma Polygonati Odorati 150 grams
The preparation technology of above-mentioned oral liquid is following:
A adds 5 times of water gagings Jiang Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati and decocts twice, and 2 hours for the first time, 2 hours for the second time;
B filters, merging filtrate, and concentrate; Add the 50-60% soak with ethanol 10-15 hour, and filtered, reclaim ethanol, add water to 300ml; Add 0.5 gram nipalgin;
C is distributed into the finished product oral liquid, every 15ml.
Embodiment 2
A kind of medicament capsule of treating gout, it is prepared from by following weight portion proportioning Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 1500 grams
Radix Achyranthis Bidentatae 750 grams
Rhizoma Polygonati Odorati 500 grams
Above-mentioned capsular preparation technology is following:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 4 times of water gagings and boil, extract 2 times, and 2 hours for the first time, 2 hours for the second time;
B filters, and merges filtrating 2 times, concentrates;
C added the 50-60% soak with ethanol 12 hours, filtered, and reclaimed ethanol, and filtrating concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, the mix homogeneously packing the finished particle agent.
Embodiment 3
A kind of medicament capsule of treating gout, it is prepared from by following weight portion proportioning Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 1500 grams
Radix Achyranthis Bidentatae 750 grams
Rhizoma Polygonati Odorati 500 grams
Above-mentioned capsular preparation technology is following:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 4 times of water gagings and boil, extract 2 times, and 2 hours for the first time, 2 hours for the second time;
B filters, and merges filtrating 2 times, concentrates;
C added the 50-60% soak with ethanol 12 hours, filtered, and reclaimed ethanol, and filtrating concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides 100 capsules of packing into, and packing promptly gets.
Claims (6)
1. Chinese medicine composition of treating gout and hyperuricemia is characterized in that it being to be processed by following weight portion proportioning crude drug:
Rhizoma Dioscoreae Septemlobae 15-45
Radix Achyranthis Bidentatae 6-15
Rhizoma Polygonati Odorati 6-15.
2. a kind of Chinese medicine composition of treating gout and hyperuricemia according to claim 1 is characterized in that it being to be processed by following weight portion proportioning crude drug:
Rhizoma Dioscoreae Septemlobae 30
Radix Achyranthis Bidentatae 15
Rhizoma Polygonati Odorati 10.
3. a kind of Chinese medicine composition of treating gout and hyperuricemia according to claim 1 and 2 is characterized in that said Chinese medicine composition is oral liquid, capsule, pill, decoction, tablet, granule, powder.
4. the method for preparing of the Chinese medicine composition of described treatment gout of claim 1 and hyperuricemia, it is made up of following steps:
A adds 3-6 times of water gaging Jiang Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati and decocts twice, and 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B filters, merging filtrate, and concentrate; Add the 50-60% soak with ethanol 10-15 hour, and filtered, reclaim ethanol, add water to aequum;
C is distributed into the finished product oral liquid.
5. the method for preparing of the Chinese medicine composition of described treatment gout of claim 1 and hyperuricemia, it is made up of following steps:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 3-6 times of water gaging and boil, extract 2 times, and 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B filters, and merges filtrating 2 times, concentrates;
C added the 50-60% soak with ethanol 10-15 hour, filtered, and reclaimed ethanol, and filtrating concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline Cellulose, the mix homogeneously packing the finished particle agent.
6. the method for preparing of the Chinese medicine composition of described treatment gout of claim 1 and hyperuricemia, it is made up of following steps:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 3-6 times of water gaging and boil, extract 2 times, and 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B filters, and merges filtrating 2 times, concentrates;
C added the 50-60% soak with ethanol 10-15 hour, filtered, and reclaimed ethanol, and filtrating concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline Cellulose, and mix homogeneously divides in the capsule of packing into, finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100300970A CN101380414B (en) | 2007-09-06 | 2007-09-06 | Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100300970A CN101380414B (en) | 2007-09-06 | 2007-09-06 | Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101380414A CN101380414A (en) | 2009-03-11 |
| CN101380414B true CN101380414B (en) | 2012-01-25 |
Family
ID=40460584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100300970A Active CN101380414B (en) | 2007-09-06 | 2007-09-06 | Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101380414B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036915A (en) * | 2016-05-24 | 2016-10-26 | 张雅萍 | Special diet composition containing marine active polypeptide as well as preparation method and application of special diet composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803177A (en) * | 2005-01-11 | 2006-07-19 | 贵阳新天药业股份有限公司 | Chinese medicinal composition for treating gout and its preparing process |
| CN1836720A (en) * | 2005-06-17 | 2006-09-27 | 本溪天印药业有限公司 | Chinese medicine composition for treating arthritis or gout and preparing method thereof |
-
2007
- 2007-09-06 CN CN2007100300970A patent/CN101380414B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803177A (en) * | 2005-01-11 | 2006-07-19 | 贵阳新天药业股份有限公司 | Chinese medicinal composition for treating gout and its preparing process |
| CN1836720A (en) * | 2005-06-17 | 2006-09-27 | 本溪天印药业有限公司 | Chinese medicine composition for treating arthritis or gout and preparing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101380414A (en) | 2009-03-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103099959B (en) | Traditional Chinese medicine preparation for treating ulcerative colitis and preparation method thereof | |
| CN102058767B (en) | Chinese medicine for treating senile chronic bronchitis and method for preparing pills thereof | |
| CN103520572B (en) | A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof | |
| CN105902906A (en) | Traditional Chinese medicine composition for treating wind-cold-type cold and cough and preparation method thereof | |
| CN101549113A (en) | Traditional Chinese medicine composition for treating urinary system stones and preparation method thereof | |
| KR20240102982A (en) | Traditional Chinese herbal medicine for the treatment of hives, eczema, allergies/kinetic reactive constitution | |
| CN101168006B (en) | Medicine for treating gastric ulcer | |
| CN103385993A (en) | Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
| CN102657736B (en) | Medicament composition for treating rheumatoid arthritis and preparation method of medicament composition | |
| CN102335300B (en) | Stone decomposing and discharging medicament | |
| CN101138613A (en) | Traditional Chinese medicine for treating acute bronchitis of children | |
| CN105641419A (en) | Traditional Chinese medicine composition for treating Yin deficiency type cough caused by lung cancer | |
| CN102178781A (en) | Chinese medicine composition for treating scrotum eczema and preparation method thereof | |
| CN1246031C (en) | Chinese patent drug-Fuyan capsdule for treating chronic pelvic inflammation | |
| CN104758900A (en) | Traditional Chinese medicine for treating acute pancreatitis | |
| CN101380414B (en) | Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof | |
| CN1772180A (en) | Chinese herbal medicine decoction for treating Yin-deficiency low fever and its prepn | |
| CN100352487C (en) | Pure Chinese medicine for treating chronic rhinitis, pharyngitis and globus hysterics | |
| CN104740540A (en) | Heat-clearing and detoxifying preparation for treating appendicitis | |
| CN104740405B (en) | A kind of Chinese medicine preparation and preparation method for treating anaphylactoid purpura renal damage | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method | |
| CN102512589B (en) | Medicine for treating early sudden deafness | |
| CN102755598B (en) | Medicine for treating acute gouty arthritis and preparation method thereof | |
| CN106344838A (en) | Chinese medicinal composition for treating oral ulcer | |
| CN1765402A (en) | Chinese herbal decoction for treating apontaneous emission of premier fire abnormal active pattern and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |