CN101380414A - Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating gout and hyperuricemia and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation for curing gout and hyperuricemia and a preparation method thereof. The traditional Chinese medicine preparation is prepared by fish poison yam, achyranthes root and fragrant solomonseal rhizome according to certain ratio of weight proportion by parts. The traditional Chinese preparation has the efficacy of removing dampness through diuresis, expelling turbid, removing blood stasis and freeing channel, removing dampness without impairment of yin, is suitable for curing the gout and the hyperuricemia caused by damp turbidity accumulating. The traditional Chinese preparation has the pharmacological actions of dramatically reducing blood uric acid and accelerating urate excretion.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of gout and hyperuricemia and preparation method thereof, be specifically a kind of be the treatment gout made of raw material and pure Chinese medicinal preparation of hyperuricemia and preparation method thereof with the natural Chinese medicinal herb.
Background technology
From the viewpoint of the traditional Chinese medical science, gout and hyperuricemia, the category of genus " arthromyodynia " is a common clinical, frequently-occurring disease.The traditional Chinese medical science to primary disease understanding early, medical secrets of official " calls its pyretic toxicity gas and go out from internal organs, and people's vital organs of the human body Jing Xing is defeated, all refers to for brothers, so poison is attacked in brothers also from interior and go out." gout is divided into acute stage and catabasis.Modern Chinese medicine thinks that too much uric acid belongs to turbid, the turbid damp of expectorant, the main cause of gout is dysfunction of the spleen in transportation or innate deficiency, spleen the clear failing to ascend and the turbid failing to descend so that endogenous damp formation, hold concurrently again excessive drinking gluttony, overstrain can impel then that the expectorant turbidity current is annotated in the joint, muscle, and it is local red and swollen scorching hot to cause QI-blood circulation freely not cause, arthralgia forms arthromyodynia unbearably, its pathogenesis is turbid damp numbness resistance meridians, the stasis of blood and heat-transformation, stagnation of QI and blood may bring about pain.Acute stage, show as gouty arthritis, and the arthromyodynia protracted course of disease enters the relative remission phase, and except that the pain due to damp and hot turbid pathogen impatency meridians are arranged, the symptom of YIN fluid deficiency also often appears in the damp and hot turbid pathogen cloudy Tianjin of burning.Reinforcement can effectively prevent developing of gout to the control of hyperuricemia, has embodied the importance of traditional Chinese medical science preventive treatment of disease.
From the viewpoint of doctor trained in Western medicine, gout is the heterogeneous chronic metabolic disease of a group due to the purine metabolism obstacle, is divided into constitutional and Secondary cases two classes, mainly shows as acute gouty arthritis, intermission and chronic arthritis clinically.The acute attack of gout is that urate is in the joint and the acute inflammatory reaction that causes with crystal form deposition of joint surrounding tissue.But the gout outbreak continues a couple of days to natural remission several weeks, and joint motion can recover fully, i.e. the so-called intermission.Gout is as if untreated, and urate increases in the intraarticular deposition, and inflammation is shown effect repeatedly and entered chronic phase.
In treatment, the medicine of doctor trained in Western medicine colchicine commonly used, NSAID (non-steroidal anti-inflammatory drug) and inhibition uricopoiesis is handled the gout patient at present, and curative effect is pretty good basically, but the side effect of allergic constitution and gastrointestinal upset is rather common.And the traditional Chinese medical science also has many side's medicines can treat gout and hyperuricemia, can select for use Radix Angelicae Sinensis to pick up pain soup, Baihu Jia Guizhi Tang, SIMIAO WAN, clear numbness Medicine wine for activating the channels according to the state of an illness, compound recipe is stretched muscle capsule, wrinkle kidney analgesic therapy capsule etc., dialectical application can obtain certain curative effect, but the raw material numerous and complicated is expensive and curative effect is still not ideal enough.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of gout and hyperuricemia.
Another object of the present invention provides the preparation method of a kind of treatment gout and antihyperuricemic Chinese medicine composition.
Chinese medicine composition of the present invention is that You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati are made.
Chinese medicine composition of the present invention has the dampness removing not effect of impairment of YIN of turbid, disperse blood stasis and dredge collateral, dampness removing of dispelling, and is mainly used in treatment gout and hyperuricemia, and the traditional Chinese medical science is distinguished to turbid damp and pented up pattern of syndrome.Chinese medicine composition of the present invention has remarkable reduction blood uric acid, quickens the pharmacological action of urate excretion.
The preparation method of Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 15-45
Rhizoma Polygonati Odorati 6-15
Radix Achyranthis Bidentatae 6-15
The preparation method of preferred Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 15-45
Rhizoma Polygonati Odorati 6-15
Radix Achyranthis Bidentatae 6-15
The preparation method of further preferred Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 30-50
Rhizoma Polygonati Odorati 15-30
Radix Achyranthis Bidentatae 10-15
The preparation method of best Chinese medicine composition of the present invention, it is prepared from by following weight portion proportioning You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 45
Rhizoma Polygonati Odorati 15
Radix Achyranthis Bidentatae 10
A kind of Chinese medicine composition for the treatment of gout and hyperuricemia of the present invention, it can make various dosage forms according to a conventional method, comprises oral liquid, capsule, pill, decoction, tablet, soft capsule, granule, powder etc.
In various dosage forms, preferred a kind of oral liquid of making by following method, this preparation method is:
A adds 3-6 times of water gagings Jiang Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati and decocts twice, and 2-2.5 hours for the first time, 1.5-2 hours for the second time;
B filters, merging filtrate, and concentrate, add 50-60% soak with ethanol 10-15 hours, filter, reclaim ethanol, add water to aequum; And add a certain amount of antiseptic;
C is distributed into finished product.
Concrete instructions of taking and consumption: oral, every day 2 times, each 15ml, 7 days acute stages were a course of treatment, one month chronic phase was a course of treatment.
In various dosage forms, also preferred a kind of capsule of making by following method, this preparation method is:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 3-6 times of water gagings and boil, extract 2 times, and 2-2.5 hours for the first time, 1.5-2 hours for the second time;
B filters, and merges 2 times filtrate, concentrates;
C adds 50-60% soak with ethanol 10-15 hours, filters, and reclaims ethanol, and filtrate concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides in the capsule shells of packing into, finished product.
The Chinese medicine of respectively distinguishing the flavor of in the Chinese medicine preparation of the present invention is crude drug.Rhizoma Dioscoreae Septemlobae in the side is perennial draft plant cotton Rhizoma Dioscoreae Septemlobae and the powder back of the body Rhizoma Dioscoreae rhizome of overgrowing of Dioscoreaceae.The little suffering of bitter in the mouth, cold nature is nontoxic.Have dampness removing and go turbidly, blood stasis dispelling dispels the wind.Modern pharmacological research finds that Rhizoma Dioscoreae Septemlobae has remarkable reduction blood uric acid, quickens the function of urate excretion.Rhizoma Dioscoreae Hypoglaucae, another name thorn Rhizoma Smilacis Glabrae, plain boiled pork Os Canitis thorn, rhizome grows wild, be bordering on ground, ring shape, leaf alternate, triangular shape heart or ovum shape lanceolar, blade is done the nearly black in back, flower unisexuality, dioecism, staminate inflorescence spike, be born in the hillside sylvan life, medicinal rhizome is cut into irregular thin slice more, differs in size, and the edge is irregular, band brownish black that has or taupe brown crust, tangent plane yellow-white or light taupe brown, smooth, mealiness is arranged, the matter pine, slightly flexible, frangibility; Rhizoma Dioscoreae Septemlobae, another name Ruan Bi Roots-of-plant is born in the bushes of hillside, and medicinal rhizome mostly is irregular inclined section, not of uniform size, crust yellowish-brown or yellowish-brown, periphery curls, and has sparse base portion to be the root trace of conical protrusions, tangent plane canescence or yellow-white, as seen yellowish-brown muscle arteries and veins point looses in vascular bundle, and the matter pine slightly is spongy.
A kind of Chinese medicine preparation for the treatment of gout and hyperuricemia of the present invention is to be prepared from by three kinds of Chinese herbal medicine, its prescription science, rationally, concertedness is good, the specially good effect side that belongs to treatment gout and hyperuricemia, the curative effect highly significant, shortcomings such as it is many to have overcome existing prescription flavour of a drug, and complex process, curative effect are not remarkable, side effect is many.
Below further specify the drug action that the present invention treats gout and hyperuricemia by clinical trial:
Method: adopt Chinese medicine) treatment gout 50 examples from intending gout soup (Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae, Rhizoma Polygonati Odorati, and establish matched group (Western medicine colchicine and NSAID (non-steroidal anti-inflammatory drug) treatment gout) 48 examples and compare.
Result: treatment group total effective rate 96.0%; Matched group total effective rate 85.4%,
Learn by statistics and handle, difference has highly significant meaning (P＜0.01).
Prompting: this method has dehumidifying row turbid to primary disease, the effect of promoting blood circulation and detumescence pain relieving, removing dampness and non-impairment of YIN.
Specific as follows:
Clinical data observes that case is that No.1 Hospital Affiliated to Zhongshan Univ.'s traditional Chinese medical science rheumatism training was in hospital in 2005 and out-patient's totally 94 examples, and employing digital watch method is divided into two groups at random.50 examples are organized in treatment, male's 45 examples, women's 5 examples, 22-72 years old ages, average 42.5 years old, course of disease 2d～25 year, average 3.93 years.Overweight people's 37 examples.Heating person's 11 examples before the treatment, fast 21 examples of erythrocyte sedimentation rate, blood uric acid increases 50 examples, leukocyte 19 examples that raise, hyperlipemia 25 examples, B ultrasonic: renal calculus 13 examples, fatty liver 14 examples; Matched group 48 examples, male 40 examples, women 8 examples, 25～71 years old age, average 41.3 years old, course of disease 1d～21 year, average 2.6 years.Overweight people's 30 examples.Heating person's 10 examples before the treatment, fast 9 examples of erythrocyte sedimentation rate, blood uric acid increases 48 examples, leukocyte 10 examples that raise, hyperlipemia 19 examples, B ultrasonic: renal calculus 6 examples, fatty liver 11 examples.2 groups of clinical datas relatively, and are roughly the same, have comparability.Diagnostic criteria according to American Rheumatism Association in 1997 about the acute gouty arthritis criteria for classification.The differentiation of symptoms and signs for classification of syndrome pyretic arthralgia: the redness and swelling of joints burning pain, it is thirsty to generate heat, red tongue with yellow fur, slippery and rapid pulse.Arthralgia due to cold: arthralgia is miserable, or the enlargement distortion, meets cold increasing the weight of, or tophus, or ulceration stream white paste, and tongue is greasy in vain, stringy and tense pulse.
Therapeutic Method treatment group: basic side forms: Rhizoma Dioscoreae Septemlobae 30g, Radix Achyranthis Bidentatae 15g, Rhizoma Polygonati Odorati 15g.Plus-minus: heating adds Flos Lonicerae, Gypsum Fibrosum, and redness adds Rhizoma Atractylodis, Cortex Phellodendri, and the pain play adds Olibanum (processed) and Myrrha, and arthralgia due to cold adds Ramulus Cinnamomi, Radix Aconiti Lateralis Preparata, and lithangiuria adds Talcum, Endothelium Corneum Gigeriae Galli, has tophus to add Rhizoma Arisaematis, the Radix Angelicae Dahuricae.Usage: 1 dose of every day, decocting 2 times, decoction being taken warmly sooner or later; Matched group: colchicine 0.5mg, 1 day 2 times, or add NSAID (non-steroidal anti-inflammatory drug) or hormone, chronic phase, can according to circumstances be selected the uric acid resisting medicine for use.2 groups was 1 course of treatment with treatment 7d all, finished the statistics therapeutic outcome 2～5 courses of treatment.
The criterion of therapeutical effect clinical cure: arthralgia disappears, and uric acid content is normal in blood and the urine, follows up a case by regular visits to 2 years not recidivists.Produce effects: arthralgia alleviates, and uric acid content obviously reduces in blood and the urine.Invalid; No change before and after the treatment.
2 groups of clinical cure rates of therapeutic outcome are (P＜0.01) relatively, and difference has the highly significant meaning, and the treatment group obviously is better than matched group.
It is that its pathogenesis basis is a hyperuricemia owing to purine metabolic disturbance causes one group of not normal disease of uric acid metabolism that gout is discussed.Western medicine is many in the treatment controls inflammation outbreak to improve symptom with colchicine and NSAID (non-steroidal anti-inflammatory drug) or hormone, adopt allopurinol, uric acid reducing such as narcaricin are with uric acid reducing, still lack the radical cure measure, in case the drug withdrawal state of an illness easily repeatedly, and the said medicine side effect is all bigger, has increased the difficulty of prolonged application.The utilization tcm syndrome differentiation and treatment, the phlegm-damp turbid pathogen is got rid of external, and is hot and suffocating clearly, and environment tends to balance in making, and hyperuricemia is removed and disease is fully recovered.This this research treatment by Chinese herbs gout is different from traditional arthromyodynia Coryza Treated by Syndrome Differentiation, and tradition thinks that the many damp and hot evil numbness resistance joint stasis of blood choke blood of exopathogen or interior life that wait because of wind and cold is damp and hot of primary disease fall ill.The rule of treatment is with clearing away heat-damp and promoting diuresis, and expelling wind and cold, blood circulation promoting and blood stasis dispelling are main.And our clinical observation finds that the turbid damp pathogen accumulates body for a long time, the stasis of blood and heat-transformation, refining Tianjin liquid that burns, numbness resistance meridians and cause gout.So treatment on dampness removing is dispelled turbid basis, add Rhizoma Polygonati Odorati with YIN nourishing, Radix Achyranthis Bidentatae with blood circulation promoting and blood stasis dispelling, that tests is clinical, can obviously reduce hyperuricemia and improve symptom, side effect is little, but longer-term is used.
The specific embodiment
Below adopt embodiment to specify a kind of Chinese medicine preparation for the treatment of gout and hyperuricemia of the present invention and preparation method thereof.
Embodiment 1
A kind of oral liquid for the treatment of gout, it is prepared from by following weight portion proportioning You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 450 grams
Radix Achyranthis Bidentatae 225 grams
Rhizoma Polygonati Odorati 150 grams
The preparation technology of above-mentioned oral liquid is as follows:
A adds 5 times of water gagings Jiang Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati and decocts twice, and 2 hours for the first time, 2 hours for the second time;
B filters, merging filtrate, and concentrate; Add 50-60% soak with ethanol 10-15 hours, filter, reclaim ethanol, add water to 300ml; Add 0.5 gram nipalgin;
C is distributed into the finished product oral liquid, every 15ml.
Embodiment 2
A kind of medicament capsule for the treatment of gout, it is prepared from by following weight portion proportioning You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 1500 grams
Radix Achyranthis Bidentatae 750 grams
Rhizoma Polygonati Odorati 500 grams
Above-mentioned capsular preparation technology is as follows:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 4 times of water gagings and boil, extract 2 times, and 2 hours for the first time, 2 hours for the second time;
B filters, and merges 2 times filtrate, concentrates;
C adds 50-60% soak with ethanol 12 hours, filters, and reclaims ethanol, and filtrate concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, the mix homogeneously packing the finished particle agent.
Embodiment 3
A kind of medicament capsule for the treatment of gout, it is prepared from by following weight portion proportioning You Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati:
Rhizoma Dioscoreae Septemlobae 1500 grams
Radix Achyranthis Bidentatae 750 grams
Rhizoma Polygonati Odorati 500 grams
Above-mentioned capsular preparation technology is as follows:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 4 times of water gagings and boil, extract 2 times, and 2 hours for the first time, 2 hours for the second time;
B filters, and merges 2 times filtrate, concentrates;
C adds 50-60% soak with ethanol 12 hours, filters, and reclaims ethanol, and filtrate concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides 100 capsules of packing into, and packing promptly.
Claims (7)
1, a kind of Chinese medicine composition for the treatment of gout and hyperuricemia is characterized in that it being to be made by following weight portion proportioning crude drug:
Rhizoma Dioscoreae Septemlobae 15-45
Radix Achyranthis Bidentatae 6-15
Rhizoma Polygonati Odorati 6-15.
2,, it is characterized in that it being to make by following weight portion proportioning crude drug according to a kind of Chinese medicine composition for the treatment of gout and hyperuricemia of claim 1:
Rhizoma Dioscoreae Septemlobae 15-45
Radix Achyranthis Bidentatae 6-15
Rhizoma Polygonati Odorati 6-15.
3,, it is characterized in that it being to make by following weight portion proportioning crude drug according to a kind of Chinese medicine composition for the treatment of gout and hyperuricemia of claim 1:
Rhizoma Dioscoreae Septemlobae 30
Radix Achyranthis Bidentatae 15
Rhizoma Polygonati Odorati 10.
4, according to a kind of Chinese medicine composition for the treatment of gout and hyperuricemia of claim 1-3, it can be oral liquid, capsule, pill, decoction, tablet, soft capsule, granule, powder.
5, a kind of preparation method for the treatment of the Chinese medicine composition of gout and hyperuricemia of claim 1, it is made up of following steps:
A adds 3-6 times of water gagings Jiang Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati and decocts twice, and 2-2.5 hours for the first time, 1.5-2 hours for the second time;
B filters, merging filtrate, and concentrate; Add 50-60% soak with ethanol 10-15 hours, filter, reclaim ethanol, add water to aequum;
C is distributed into the finished product oral liquid.
A kind of preparation method for the treatment of the Chinese medicine composition of gout and hyperuricemia of 6 claim 1, it is made up of following steps:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 3-6 times of water gagings and boil, extract 2 times, and 2-2.5 hours for the first time, 1.5-2 hours for the second time;
B filters, and merges 2 times filtrate, concentrates;
C adds 50-60% soak with ethanol 10-15 hours, filters, and reclaims ethanol, and filtrate concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, the mix homogeneously packing the finished particle agent.
A kind of preparation method for the treatment of the Chinese medicine composition of gout and hyperuricemia of 7 claim 1, it is made up of following steps:
A mixes Rhizoma Dioscoreae Septemlobae, Radix Achyranthis Bidentatae and Rhizoma Polygonati Odorati after crude drug is handled, add 3-6 times of water gagings and boil, extract 2 times, and 2-2.5 hours for the first time, 1.5-2 hours for the second time;
B filters, and merges 2 times filtrate, concentrates;
C adds 50-60% soak with ethanol 10-15 hours, filters, and reclaims ethanol, and filtrate concentrates, and is spray dried to fine powder;
The D fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides in the capsule of packing into, finished product.
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| CN106036915A (en) * | 2016-05-24 | 2016-10-26 | 张雅萍 | Special diet composition containing marine active polypeptide as well as preparation method and application of special diet composition |
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| CN100348248C (en) * | 2005-01-11 | 2007-11-14 | 贵阳新天药业股份有限公司 | Chinese medicinal composition for treating gout and its preparing process |
| CN100488552C (en) * | 2005-06-17 | 2009-05-20 | 辽宁好护士药业（集团）有限责任公司 | Chinese medicine composition for treating arthritis or gout and preparing method thereof |
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| CN106036915A (en) * | 2016-05-24 | 2016-10-26 | 张雅萍 | Special diet composition containing marine active polypeptide as well as preparation method and application of special diet composition |
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