CN102908403B - Chinese materia medica preparation for treating gout and preparation method thereof - Google Patents
Chinese materia medica preparation for treating gout and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese materia medica preparation for treating gout and a preparation method thereof. The Chinese materia medica preparation is prepared by natural Chinese herbal medicines, and the Chinese materia medica preparation is prepared by plantain herb, radish and folium mori in proportion in part by weight. Dosage forms of the Chinese materia medica preparation comprise an oral solution, a tablet, a capsule, granules and the like. The Chinese materia medica preparation has effects of clearing heat and expelling damp, conducting diuresis and discharges poison, activating meridians to stop pain and conducting detumescence, is obvious in treatment effects, is small in side effect on human body and the like. The Chinese materia medica preparation can obviously reduce urico acid, quicken urico acid discharge and achieve double effects of treating and preventing gout. The preparation is simple in ingredient, practical and low in medicine price, is a good formula to treat and prevent the gout, and can be widely popularized and applied.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, be specifically related to a kind of Chinese medicine preparation for the treatment of gout and preparation method thereof, belong to the Chinese medicine preparation production technical field.
Background technology
Gout is the systemic disease that causes purine metabolism obstacle and metabolic arthritis to cause due to heritability or the acquired cause of disease.The viewpoint of the traditional Chinese medical science is: gout and hyperuricemia, the category of genus " arthromyodynia ", be common clinical, frequently-occurring disease.Gout is divided into acute stage and catabasis.Modern Chinese medicine thinks that too much uric acid belongs to that expectorant is turbid, turbid damp, the main cause of gout is dysfunction of the spleen in transportation, spleen opening or cleaning the turbid descending mistake department so that endogenous damp formation, double excessive drinking gluttony again, overstrain, impel that the expectorant turbidity current is annotated in joint, muscle, cause QI-blood circulation freely not cause local red and swollen scorching hot, arthralgia forms arthromyodynia unbearably.Acute stage, show as gouty arthritis, and circuitous not the prolonging of arthromyodynia more enters the relative remission phase, and except there being damp and hot turbid pathogen impatency meridians to cause pain, the symptom of YIN fluid deficiency, also often appear in the damp and hot turbid pathogen cloudy Tianjin of burning.The viewpoint of doctor trained in Western medicine is: gout is the heterogeneous chronic metabolic disease of a group due to the purine metabolism obstacle, is divided into constitutional and Secondary cases two classes, and main manifestations is acute gouty arthritis, intermission and chronic arthritis clinically.But the gout outbreak continues a couple of days to natural remission several weeks, and joint motion can recover fully, i.e. the so-called intermission.If the gout untreated, urate increases in the intraarticular deposition, and inflammation is repeatedly shown effect and entered chronic phase.
The goat of China after the eighties in 20th century is on the rise, causes many scholars more and more to pay attention to the treatment research of gout, and Chinese medicine, therapy of combining Chinese and Western medicine gout also obtain greater advance.Because the medicine of doctor trained in Western medicine colchicine commonly used, NSAID (non-steroidal anti-inflammatory drug) and inhibition uricopoiesis is processed gout patients, can play good curative effect, but there is huge toxic and side effects in the Western medicine of gout treatment, and the long-term taking Western medicine is very large to the hepatorenal damage of gout patients.And the Chinese traditional treatment effect is remarkable, has no side effect.Applied for treating the patent of gout: as application number, be 2012100044640, described Chinese medicine is usingd Radix Raphani as raw material, and the treatment gout reaches certain effect.Retrieval simultaneously finds to also have the patent of many prescription application treatment gouts and hyperuricemia, but the prescription raw material numerous and complicated that has, or single flavor treatment by Chinese herbs effect is not ideal enough, and some prescription price of medicinal materials are high, and patient is difficult to bear financial burden.Therefore, in the urgent need to developing crude drug, accomplish low price and the effective new product of Chinese medicine for the treatment of gout, for vast patient with gout, remove misery, make patient with gout recover as early as possible healthy.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of gout, this Chinese medicine preparation has the effect of clearing heat and expelling damp, diuresis toxin expelling, removing obstruction in the collateral to relieve pain and detumescence, evident in efficacy, to the advantage such as the human body side effect is little, remarkable reduction blood uric acid is arranged, accelerate the effect of urate excretion, reach the double effects for the treatment of and prevention gout.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine preparation of gout.
For realizing the purpose of foregoing invention, the technical scheme that the present invention takes is as follows: Chinese medicine preparation of the present invention is crude drug, Herba Plantaginis, Radix Raphani and Folium Mori, consists of, and by following weight portion proportioning, is prepared from:
Herba Plantaginis 30-60 part
Radix Raphani 20-40 part
Folium Mori 20-30 part;
The preparation method of preferred Chinese medicine preparation of the present invention, it is prepared from by following weight ratio proportioning by Herba Plantaginis, Radix Raphani and Folium Mori:
Herba Plantaginis 30-50 part
Radix Raphani 20-30 part
Folium Mori 20-30 part;
The preparation method of further preferred Chinese medicine preparation, it is prepared from by following weight portion proportioning by Herba Plantaginis, Radix Raphani and Folium Mori:
Herba Plantaginis 40-60 part
Radix Raphani 30-40 part
Folium Mori 25-30 part;
The preparation method of best Chinese medicine preparation, it is prepared from by following weight portion proportioning by Herba Plantaginis, Radix Raphani and Folium Mori:
50 parts of Herba Plantaginiss
30 parts of Radix Raphanis
25 parts, Folium Mori.
A kind of Chinese medicine preparation for the treatment of gout of the present invention, it can make various dosage forms according to a conventional method, comprises oral liquid, decoction, tablet, powder, capsule and granule etc.
In various dosage forms, preferred a kind of oral liquid of being made by following method, this preparation method is:
(1) Herba Plantaginis, Radix Raphani and Folium Mori are added to 3-5 times of water gaging and decoct 2 times, the 1st 1.5-2.5 hour, the 2nd 1-2 hour;
(2) filtration, merging filtrate concentrated, add 50-60% soak with ethanol 10-13 hour, filters, and reclaims ethanol, adds water to aequum, and add a certain amount of antiseptic;
(3) be distributed into finished product.
Concrete instructions of taking and consumption: oral, every day 2 times, each 15ml, 7 days acute stages were a course for the treatment of, one month chronic phase was a course for the treatment of.
In various dosage forms, also preferred a kind of capsule of being made by following method, this preparation method is:
(1) Herba Plantaginis, Radix Raphani and Folium Mori are mixed after crude drug is processed, add 3-5 times of water gaging and boil, extract the 1st 1.5-2.5 hour, the 2nd 1-2 hour 2 times;
(2) filter, merge 2 times filtrate, concentrated;
(3) after concentrated, add 50-60% soak with ethanol 10-13 hour, filter, reclaim ethanol, filtrate is concentrated, then is spray dried to fine powder;
(4) fine powder adds appropriate amount of starch, microcrystalline Cellulose, mix homogeneously, be distributed in capsule shells, finished product.
The Chinese medicine of respectively distinguishing the flavor of in Chinese medicine preparation of the present invention is crude drug, and its performance of Fang Zhongsan kind crude drug and effect are described below:
Herba Plantaginis: have another name called the wheel dish, be the Plantaginaceae perennial herb.Be grown in the ground such as hill, roadside, flower nursery, rivers and ponds, rhizome cripetura, plumpness, the close palpus shape root of giving birth to.The whole roots of leaf are given birth to, blade smoothly, extensively avette, edge is wavy, not obvious cognate is arranged, five of master pulses, to the blade back projection, become the rib shape to stretch into petiole, blade is normal and petiole is isometric.Spring and summer autumn strain body central authorities pumping spike, spend littlely, corolla is not remarkable.Tie oval capsule, style is deposited in the place, top, and when ripe, lid splits, and spreads out seed.Effect: clearing away heat and promoting diuresis, removing heat from blood, detoxifcation, liver heat removing and eyesight improving, eliminate the phlegm etc., not only pharmaceutically acceptable, go back edible, be loved by the people.
Radix Raphani: crucifer, another name: Radix Raphani, reed Fu, purple ancient name for Chinese cabbage, pod, trailing plants Seedling, trailing plants are white, shepherd's purse root etc.The Radix Raphani of indication of the present invention is the kind of agricultural breeding expert through special cultivation, as the large Radix Dauci Sativae shape in northeast, and finished diameter size 6-10 centimetre, weight 100-150 gram, bright-colored even.The nature and flavor of Radix Raphani: Xin Gan, cool, nontoxic; Gui Jing: enter lung, stomach, main sharp the five internal organs; QI invigorating: very sharp joint, except the five internal organs apoplexy, except bad odor in the five internal organs.Sector-style gas, the steam that uncharms, the chest stuffiness relieving diaphragm, sharp defecation; The nature and flavor of Folium Raphani: arduous, flat; Gui Jing: enter taste.Cure mainly: control beriberi and walk pain, the promoting the circulation of QI that promotes the production of body fluid, removing obstruction in the collateral to relieve pain, removing dampness.
Folium Mori: the dried leaves of moraceae plants Mulberry, have another name called a Mulberry, Jing Sang, Fructus Mori, yellow wood etc., nature and flavor are bitter, sweet, cold in nature.Have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis, have remarkable effect to symptoms such as hyperlipidemia, hyperglycemia, fatty liver and hypertension especially.Tang Materia Medica: decocting is got extract, except beriberi, edema, and sharp intestine and small intestine, the effect of visible this crude drug of Folium Mori.
The invention has the beneficial effects as follows: this Chinese medicine preparation is to be prepared from by three kinds of natural Chinese medicinal herb, its prescription science, reasonable, concertedness is good, makes drug price cheap, belongs to the specially good effect side for the treatment of goat, the curative effect highly significant, existing prescription flavour of a drug have been overcome many, the shortcoming such as complex process, curative effect are not remarkable, the present invention, to take stopgap measures as main, takes into account it.
Chinese medicine preparation of the present invention has clearing heat and expelling damp, diuresis, toxin expelling, and the effect of removing obstruction in the collateral to relieve pain is mainly used in treating gout and hyperuricemia.Chinese medicine preparation of the present invention has remarkable reduction blood uric acid, accelerates the pharmacological action of urate excretion.
Below by clinical trial, further illustrate the drug action that the present invention treats goat:
Method: adopt Chinese medicine from intending gout soup (Herba Plantaginis, Radix Raphani, Folium Mori) treatment gout 100 examples, and (Western medicine colchicine and NSAIDs in Treatment gout 20 examples contrast to establish matched group.
Result: treatment group total effective rate 97%, matched group total effective rate 81%.
Specific as follows:
Clinical data is observed and to be provided data in 2011 with Guangzhou modern health (gout) outpatient service, is divided into two groups, 120 for the treatment of groups, age 30-75 year, average 43 years old, course of disease 3-20.Patient with gout is mostly difficult on foot, the redness and swelling of joints burning pain, and indivedual enlargements distortion, meet the cold characteristics such as increase the weight of, some tophus, or ulceration stream white paste, there is situation overwhelmed with sorrow in the patient.These clinical 100 are all adopted the Chinese medicine preparation treatment, and 20 are all adopted western medicine.
The treatment by Chinese herbs method: basic side consists of Herba Plantaginis 50 grams, Radix Raphani 25 grams, Folium Mori 25 grams; Usage: 2 doses of every days, decocting 2 times, decoction being taken warmly sooner or later; Matched group: 0.5 milligram of colchicine, 1 day 2 times, or add NSAID (non-steroidal anti-inflammatory drug) or hormone, chronic phase, can according to circumstances be selected the uric acid resisting medicine.Two groups all to treat 7 days as a course for the treatment of, and 2-4 finishes the statistics therapeutic outcome course for the treatment of.Now part patient with gout medical history is described below:
Liu * *, man 48 years old, company manager.Gout has reached 12 years, symptom: unbearably, the foot redness, because lacking exercise and work is overworked and caused for the foot arthralgia.Seven days rear feet redness that obviously disappears, can slowly walk after taking Chinese medicine, and the rear foot can normally be walked and not ache in 20 days.
Old * *, the female, 65 years old, the retired professor, gout has reached 16 years, symptom: foot can't walk any longer and can only hold up seat, and western medicine commonly used, recurred after curing several times in the past.From changing, take treatment by Chinese herbs after 15 days, can be slowly, foot does not ache, and 3 doses of rear increases every days, after 30 days, can walk normal, and nothing recurs.
The criterion of therapeutical effect clinical cure: arthralgia disappears, and in blood and urine, uric acid content is normal, follows up a case by regular visits to in October, 2012, does not find invalid and disease relapse.Produce effects: arthralgia alleviates, and in blood and urine, uric acid content obviously reduces.
Therapeutic outcome: above 2 groups of clinical cures are (P<0.01) relatively, and difference has the highly significant meaning, with the treatment by Chinese herbs gout, obviously is better than using the western medicine gout.
Gout is that its pathogenesis basis is hyperuricemia because purine metabolic disturbance causes one group of not normal disease of uric acid metabolism.In treatment, Western medicine controls inflammation outbreak to improve symptom mainly with colchicine and NSAID (non-steroidal anti-inflammatory drug) or hormone.Adopt allopurinol, the celestial grade of gout example reduced uric acid to reduce uric acid, still lacks the radical cure measure, in case the drug withdrawal state of an illness easily repeatedly, and the said medicine side effect is all larger, has increased the difficulty of prolonged application.
The specific embodiment
Below by example, the present invention is described in further details, these examples only are used for illustrating the present invention, do not limit the scope of the invention.
Embodiment 1
A kind of oral liquid for the treatment of gout, it is prepared from by following weight portion proportioning example by Herba Plantaginis, Radix Raphani and Folium Mori:
Herba Plantaginis 500 grams
Radix Raphani 300 grams
Folium Mori 250 grams;
The preparation technology of above-mentioned oral liquid is as follows:
(1) Herba Plantaginis, Radix Raphani, Folium Mori are added to 4 times of water gagings and decoct secondary, the 1st time 2 hours, the 2nd time 1.5 hours;
(2) filter, merging filtrate, and concentrated, add 50-60% soak with ethanol 10-13 hour, filter, reclaim ethanol, add water to 350 milliliters, add 0.5 gram nipalgin;
(3) be distributed into the finished product oral liquid, 15 milliliters every.
Embodiment 2
A kind of medicament capsule for the treatment of gout, it is prepared from by following weight portion proportioning by Herba Plantaginis, Radix Raphani and Folium Mori:
Herba Plantaginis 1800 grams
Radix Raphani 1000 grams
Folium Mori 800 grams;
The preparation technology of above-mentioned capsule is as follows:
(1) Herba Plantaginis, Radix Raphani and Folium Mori are mixed after crude drug is processed, add 3 times of water gagings and boil, extract 2 times, the 1st time 2 hours, the 2nd time 1.5 hours;
(2) filter, merge 2 filtrates, concentrated;
(3) after concentrated, added the 50-60% soak with ethanol 12 hours, filter, reclaim ethanol, filtrate is concentrated, is spray dried to fine powder;
(4) fine powder adds appropriate amount of starch, microcrystalline cellulose, the mix homogeneously packing the finished particle agent.
Embodiment 3
A kind of medicament capsule for the treatment of gout, it is prepared from by following weight portion proportioning by Herba Plantaginis, Radix Raphani and Folium Mori:
Herba Plantaginis 1800 grams
Radix Raphani 1000 grams
Folium Mori 800 grams;
The preparation technology of above-mentioned capsule is as follows:
(1) Herba Plantaginis, Radix Raphani and Folium Mori are mixed after crude drug is processed, add 3 times of water gagings and boil, extract 2 times, the 1st time 2 hours, the 2nd time 1.5 hours;
(2) filter, merge 2 times filtrate, concentrated;
(3) after concentrated, added the 50-60% soak with ethanol 12 hours, filter, reclaim ethanol, filtrate is concentrated, is spray dried to fine powder;
(4) fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously, be distributed into 100 capsules, or packed products.
Claims (5)
1. Chinese medicine preparation for the treatment of gout, it is characterized in that: this Chinese medicine preparation is made by following weight portion proportioning crude drug:
Herba Plantaginis 30-60 part
Radix Raphani 20-40 part
Folium Mori 20-30 part.
2. a kind of Chinese medicine preparation for the treatment of gout according to claim 1, it is characterized in that: this Chinese medicine preparation is made by following weight portion proportioning crude drug:
40 parts of Herba Plantaginiss
30 parts of Radix Raphanis
25 parts, Folium Mori.
3. the preparation method for the described treatment gout of claim 1 or 2 Chinese medicine preparation, is characterized in that: comprise the steps:
(1) Herba Plantaginis, Radix Raphani and Folium Mori are added to 3-5 times of water gaging and decoct 2 times, the 1st 1.5-2.5 hour, the 2nd 1-2 hour;
(2) filtration, merge filtrates concentrated 2 times, after concentrating, adds 50-60% soak with ethanol 10-13 hour, filters, and after recovery ethanol, adds water to aequum, and add a certain amount of antiseptic;
(3) be distributed into the finished product oral liquid.
4. the preparation method of the described treatment gout of claim 1 or 2 Chinese medicine preparation, is characterized in that: comprise the steps:
(1) Herba Plantaginis, Radix Raphani and Folium Mori are mixed after crude drug is processed, add 3-5 times of water gaging and boil, extract the 1st 1.5-2.5 hour, the 2nd 1-2 hour 2 times;
(2) filter, merge filtrate concentrated 2 times;
(3) after concentrated, add 50-60% soak with ethanol 10-13 hour, filter, reclaim ethanol, filtrate is concentrated, is spray dried to fine powder;
(4) fine powder adds appropriate amount of starch, microcrystalline Cellulose, the mix homogeneously packing the finished particle agent.
5. the preparation method of the described treatment gout of claim 1 or 2 Chinese medicine preparation, is characterized in that: comprise the steps:
(1) Herba Plantaginis, Radix Raphani and Folium Mori are mixed after crude drug is processed, add 3-5 times of water gaging and boil, extract the 1st 1.5-2.5 hour, the 2nd 1-2 hour 2 times;
(2) filter, merge 2 times filtrate, concentrated;
(3) after concentrated, add 50-60% soak with ethanol 10-13 hour, filter, reclaim ethanol, filtrate is concentrated, is spray dried to fine powder;
(4) fine powder adds appropriate amount of starch, microcrystalline Cellulose, and mix homogeneously is distributed into capsule, finished product.
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| CN103830374B (en) * | 2014-03-06 | 2016-06-08 | 天津中医药大学 | The application in hyperuricemia clearly of three leaf glycolipids |
| CN104366636B (en) * | 2014-10-30 | 2016-07-20 | 袁丁 | A kind of Gynura procumbens (Lour.) Merr. compound formulation and preparation method and application |
| CN109865051A (en) * | 2019-04-03 | 2019-06-11 | 苏州胜柏健康食品有限公司 | A kind of traditional Chinese medicinal components aloe refrigerant mastic and cooperate its for oral administration |
| CN115957279B (en) * | 2022-12-02 | 2024-05-14 | 纳百植(广州)生物科技有限公司 | Composition with xanthine oxidase inhibition effect and application thereof |
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| CN101721563A (en) * | 2009-11-09 | 2010-06-09 | 徐兆云 | Three high rehabilitation tea |
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