CN104906467A - Traditional Chinese medicine composition for treating gout and preparation method - Google Patents
Traditional Chinese medicine composition for treating gout and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gout and a preparation method. The composition is prepared through main raw materials of, by weight, 12 parts to 16 parts of, glossy privet fruits, 8 parts to 13 parts of chinaroot greenbrier rhizomes, 10 parts to 14 parts of flax, 7 parts to 12 parts of teasel roots, 9 parts to 15 parts of Japanese fatsia, 6 parts to 10 parts of rubus crataegifolius bunge, 12 parts to 16 parts of cortex magnoliae officinals, 9 parts to 14 parts of aculeate staff-tree, 13 parts to 18 parts of clematis, 8 parts to 15 parts of cacumen biotae, 10 parts to 16 parts of bauhinia champloni benth, 7 parts to 11 parts of Chinese photinia leaves, 9 parts to 16 parts of himalayan coralbean bark, 8 parts to 14 parts of thinleaf machilus roots and 11 parts to 15 parts of yerbadetajo herbs. The composition is prepared through common traditional Chinese medicine materials, has the effects of heat clearing and toxicity removing, damp clearing and collateral dredging and swelling and pains relieving and is apparent in gout treatment effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition and method for making thereof for the treatment of gout.
Background technology
Gout is a kind of due to biosynthesis of purine metabolism increase, and uric acid produces too much or the uric acid rising in hyperamization because urate excretion is bad, and urate crystal is deposited on the repeated relapsing inflammatory diseases caused in synovium of joint, synovial bursa, cartilage and hetero-organization thereof.Primary disease is can find the single water Monosodium urate crystallization having two-fold photosensitiveness for its feature in joint fluid and tophus.Its Clinical symptoms is: hyperuricemia and urate crystal, characteristic acute arthritis, tophus, interstitial nephritis caused by deposition, and severe patient is shown in joint deformity and dysfunction, the uric acid lithangiuria of normal companion.Be more common in middle-aging male and the postmenopausal women of bodily form obesity.Along with economic development and lifestyle change, its prevalence rises gradually.
Though the traditional Chinese medical science thinks that gout one disease belongs to arthromyodynia, its sharp ache, recurrent exerbation, touchingly not heal, thus joint deformity, and have multiple complications, thus other in general arthromyodynia again.The traditional Chinese medical science thinks the strongly fragrant heat-transformation of a specified duration of heresy of the many heresies damp and hot by diseases caused by exogenous pathogenic factor of primary disease or wind and cold, or internal injury deficiency of the liver and kindey or arthromyodynia are with the passing of time, blood stasis stagnation of phlegm and causing.The many heresies because of diseases caused by exogenous pathogenic factor rheumatism cold and heat of generation of primary disease, stay and do not go; Or blood stasis stagnation of phlegm; Or positive QI-insufficiency, caused by liver and kidney deficiency etc., cause QI-blood circulation not smooth, limbs, meridians, joint impatency, stagnation of QI and blood may bring about pain.Doctor trained in Western medicine thinks that gout is the disease caused by one group of purine metabolic disturbance.Its clinical characters is hyperuricemia, and causes gouty acute arthritis recurrent exerbation therefrom, tophaceous deposition, tophaceous chronic arthritis and joint deformity, and normal accumulation kidney causes chronic interstitial nephritis and uric acid kidney stones to be formed.Primary disease increases reason according to uric acid in blood can be divided into constitutional and the large class of Secondary cases two.The cause of disease of primary gout is except minority is caused by congenital purine metabolic disturbance, and belong to outside hereditary, great majority are not yet illustrated.The cause of disease of secondary gout can by nephropathy, leukemia, and the many reasons such as medicine cause, and primary disease is apt to occur in male and menopausal women, and male is more than women, and the ratio of men and women is about 20:1.
At present, the medicine for the treatment of gout also has a lot, for the problems referred to above, publication number CN 104189662 A (application number 201410423046.4) patent document discloses a kind of Tibetan medicine for the treatment of gout, be made up of following medicine material, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) 8-12 gram, Radix Rumicis Crispi 8-12 gram, Rhizoma Smilacis Glabrae 5-7 gram, Cortex Eucommiae 4-6 gram, Colchicum autumnale 2-4 gram, Herba Plantaginis 4-6 gram, Flos Carthami 4-6 gram, Cacumen Platycladi 2-4 gram, Ganoderma 3-5 gram, and above medicine material to be mixed.Publication number CN 103735671 A(application number 201310731795.9) patent document discloses a kind of medicine for the treatment of gout, be made up of oral preparations and external preparation, described oral preparations is by weight proportion Squama Manis raw cook 3-5 part, Radix Dauci Sativae 1-3 part, Radix Clematidis 1-2 part, Caulis Spatholobi 1-2 part, Caulis Piperis Kadsurae 1-2 part, Rhizoma Corydalis entangles 1-3 part, Spora Lygodii 1-3 part, Radix Cynanchi Paniculati 1-3 part, Semen Plantaginis 1-3 part, Herba Lysimachiae 1-3 part, Flos Carthami 1-2 part, Radix Notoginseng 1-2 part, Fructus Liquidambaris 1-2 part, Rhizoma Drynariae 1-3 part, Hirudo 0.5-2 part, Herba Centipedae 0.5-1 part, Radix Glycyrrhizae 0.5-1 part is made, described external preparation Radix Notoginseng 2-5 part, Rhizoma Sparganii 2-4 part, Rhizoma Curcumae 1-2 part, Rhizoma Chuanxiong 1-3 part, Myrrha 1-2 part, Semen Strychni 1-2 part, Herba Patriniae 1-2 part, Spina Gleditsiae 0.5-2 part, Cortex Phellodendri 1-2 part, Semen Vaccariae 0.5-1 part, make through water extraction.Publication number CN 104623439 A (application number 201510030007.2) patent document discloses a kind of liniment for the treatment of gout, by following medicinal materials and medicinal alcohol formulated: 4 grams, Moschus, Radix Notoginseng 45-55 gram, Rhizoma Smilacis Glabrae 70-80 gram, Pseudobulbus Cremastrae Seu Pleiones 45-55 gram, its preparation method is as follows: 1) above-mentioned Radix Notoginseng, Rhizoma Smilacis Glabrae and Pseudobulbus Cremastrae Seu Pleiones are cleaned and dry, pulverizing is placed in percolate pot, adds the medicinal alcohol 1000 milliliters that concentration is 53%; Flood 24 hours, collect liquid of filtering; 2) above-mentioned Moschus is put into container, add concentration be 95% medicinal alcohol appropriate, grind molten, obtain Moschus mixed liquor; 3) above-mentioned liquid and the Moschus mixed liquor of filtering mixed, leave standstill, filter.
The medicine of current treatment gout is limited, normal based on Western medicine, between period of disease, mainly take colchicine add analgesic type drug, take the medicines such as other purine between interval period of disease and reduce uric acid, but Western medicine toxic and side effects is large, cause very large injury to the heart of patient, lung, kidney, liver, long-term prescription often makes physical function degenerate and forms dependency to medicine, and patient usually can not tolerate.Chinese medicine aspect also imperfection, the curative effect of only a few herbs is also undesirable.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of Chinese medicine composition for the treatment of gout, and adopt Chinese crude drug comparatively common in the localities as raw material, the dialectical compatibility of each raw material, has effect of heat-clearing and toxic substances removing, treatment of arthritis and promoting collateral and channels, reducing swelling and alleviating pain.Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for gout, take off the primary raw material stating weight proportion and be prepared from: Fructus Ligustri Lucidi 12-16 part; Rhizoma Smilacis Chinensis 8-13 part; Caulis et Folium Lini 10-14 part; Radix Dipsaci 7-12 part; Rhizoma et Radix Dysosmae Veitchii 9-15 part; Pallet 6-10 part; Mangnolia officinalis 12-16 part; Celastrus aceleatus Merr 9-14 part; Radix clematidis floridae 13-18 part; Cacumen Platycladi 8-15 part; Caulis Bauhiniae Championii 10-16 part; Photiniaserrulata 7-11 part; Cortex erythrinae 9-16 part; great Ye south Soviet Union 8-14 part; Herba Ecliptae 11-15 part.
Treat a Chinese medicine composition for gout, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Fructus Ligustri Lucidi 13-15 part; Rhizoma Smilacis Chinensis 10-12 part; Caulis et Folium Lini 11-13 part; Radix Dipsaci 9-11 part; Rhizoma et Radix Dysosmae Veitchii 11-13 part; Pallet 7-9 part; Mangnolia officinalis 13-15 part; Celastrus aceleatus Merr 11-13 part; Radix clematidis floridae 14-16 part; Cacumen Platycladi 11-13 part; Caulis Bauhiniae Championii 12-14 part; Photiniaserrulata 8-10 part; Cortex erythrinae 12-14 part; great Ye south Soviet Union 10-12 part; Herba Ecliptae 12-14 part.
Treat a Chinese medicine composition for gout, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Fructus Ligustri Lucidi 14 parts; Rhizoma Smilacis Chinensis 11 parts; 12 parts, Caulis et Folium Lini; Radix Dipsaci 10 parts; Rhizoma et Radix Dysosmae Veitchii 12 parts; 8 parts, pallet; Mangnolia officinalis 14 parts; Celastrus aceleatus Merr 12 parts; Radix clematidis floridae 15 parts; Cacumen Platycladi 12 parts; Caulis Bauhiniae Championii 13 parts; Photiniaserrulata 9 parts; Cortex erythrinae 13 parts; great Ye south Soviet Union 11 parts; Herba Ecliptae 13 parts.
Present invention also offers the preparation method above-mentioned a kind of Chinese medicine composition for the treatment of gout being made pharmaceutically acceptable pill, capsule, oral liquid, syrup and tablet.
Described a kind of preparation method for the treatment of the Chinese medicine composition pill of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder,
(5) be placed in pot by Mel, slow fire is tempered and is endured to thick to Mel, mixes step (4) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferred diameter is 3-5mm, and being more preferably diameter is 4mm) by traditional Chinese medical science tradition pill method.
According to preparation method recited above, preferred scheme is: the consumption of the preferred Mel of step (5) is the 10%-20% of medicated powder quality, and the consumption being more preferably Mel is 15% of medicated powder quality.
Instructions of taking: each 6-8 ball, every day 2 times, 5 days courses for the treatment of.
Described a kind of preparation method for the treatment of the Chinese medicinal composition capsules of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder,
(5) step (4) gained medicated powder is made capsule (preferred 0.5g/ grain) by the specification of 0.4-0.6g/ grain.
Instructions of taking: each 2, every day 2 times, 5 days courses for the treatment of.
Described a kind of preparation method for the treatment of the Chinese medicine composition oral liquid of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, add simple syrup, mixing, high temperature sterilization 10-20 minute (preferred high temperature sterilization 13-17 minute, be more preferably high temperature sterilization 15 minutes), sterile packaged is carried out with the specification of often propping up 6ml.
According to preparation method recited above, preferred scheme is: the consumption of the preferred simple syrup of step (4) is the 6%-10% of quality of liquid medicine, and the consumption being more preferably simple syrup is 8% of quality of liquid medicine.
Instructions of taking: each 1, every day 2 times, 5 days courses for the treatment of.
Described a kind of preparation method for the treatment of the Chinese medicine composition syrup of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), (consumption of preferred sorbic acid is the 0.02%-0.04% of thick paste quality to add sorbic acid, the consumption being more preferably sorbic acid is 0.03% of thick paste quality), mix homogeneously, sterile packaged.
Instructions of taking: each 6-8g, with the warm boiled water of 35-40 DEG C, every day 2 times, 5 days courses for the treatment of.
Described a kind of preparation method for the treatment of the Chinese medicine composition tablet of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.10-1.20(45 DEG C) thick paste (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), granulate, tabletting, dry, sugar coating.
Instructions of taking: each 2, every day 2 times, 5 days courses for the treatment of.
Beneficial effect of the present invention is mainly reflected in:
1, a kind of Chinese medicine composition for the treatment of gout of the present invention adopts Chinese crude drug comparatively common in the localities as raw material, has effect of heat-clearing and toxic substances removing, treatment of arthritis and promoting collateral and channels, reducing swelling and alleviating pain.
2, can limb aching pain be removed by taking Chinese medicine composition of the present invention, can relieve the pain again, making the vital organs of the human body in order, fundamentally treating gout.
3, the present invention adopts Common Chinese Herbs to make, and cost is low, has no side effect, to health without any injury, safe and reliable, and therapeutic effect is desirable.
4, the present invention makes gout attack times obviously reduce, and interval time extends, and treatment gout is evident in efficacy.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
The pharmacological effect of each crude drug is respectively:
Fructus Ligustri Lucidi: sweet in the mouth, hardship, cool in nature.Return liver, kidney channel.For the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.There is nourishing the liver and kidney, effect of improving eyesight black hair.For Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Rhizoma Smilacis Chinensis: sweet in the mouth, micro-hardship, puckery, property is put down.Return liver, kidney channel.For the dry rhizome of liliaceous plant Rhizoma Smilacis Chinensis.There is expelling wind and removing dampness, effect of removing toxic substances dissipating blood stasis.Ache for muscles and bones, dribbling urination, profuse leukorrhea, furuncle carbuncle.
Caulis et Folium Lini: sweet in the mouth, property is put down.Return lung, liver, large intestine channel.For the root of flax family (Linaceae) plant Caulis et Folium Lini.Containing vanillic acid, syringic acid, xanthine, apigenin-8-C-glucoside, isovanillin, (E)-3,3'-dimethoxy-4 ', 4'-dihydroxy-stilbene, 2-methoxyl group hydroquinone-4-β-D-pyranglucoside, cupreol and stigmasterol mixture, berberine hydrochloride.Have pain relieving, convergence, analgesia, diuresis, skin moistening, reduces phlegm, effect of suppuration.For furuncle, bronchitis, burn, cancer, flu, conjunctivitis, cough, diarrhoea, gonorrhea, gout, inflammation, rheumatism, scalds, sclerosis, spasm, tumor.
Radix Dipsaci: bitter in the mouth, pungent, slightly warm in nature.Return liver, kidney channel.For the dry root of Dipsacaceae plant Radix Dipsaci.There is invigorating the liver and kidney, bone and muscle strengthening, continuous injured, effect of only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down, prepared RADIX DIPSACI with yellow rice wine are used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Rhizoma et Radix Dysosmae Veitchii: acrid in the mouth, hardship, warm in nature.For leaf or the root bark of Araliaceae Rhizoma et Radix Dysosmae Veitchii platymiscium Rhizoma et Radix Dysosmae Veitchii.There is preventing phlegm from forming and stopping coughing, expelling wind and removing dampness, effect of blood-activating analgetic.For cough with asthma, rheumatic arthralgia, gout, traumatic injury.
Pallet: sour in the mouth, micro-hardship, property is put down.For the root of Rosaceae rubus pallet.There is heat-clearing and toxic substances removing, reducing swelling and alleviating pain, effect of hemostasis.For influenza, children with high fever induced convulsions, laryngopharynx swelling and pain, toothache, headache, bones and muscles pain due to rheumatism, scrofula, furuncle and phyma.
Mangnolia officinalis: bitter in the mouth, pungent, warm in nature.Return spleen, stomach, lung, large intestine channel.For the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.Have dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full effect.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Celastrus aceleatus Merr: bitter in the mouth, pungent, cool in nature.Return liver, gallbladder, kidney channel.For the root of Celastraceae plant Celastrus aceleatus Merr.There is heat-clearing and toxic substances removing, effect of expelling wind and removing dampness.For rheumatic arthralgia, gout, nephritis, cholecystitis, leukemia.
Radix clematidis floridae: bitter in the mouth, micro-pungent, warm in nature.Return liver,spleen,kidney warp.For Herb or the root of Ranunculaceae Actions of Clematis Species Radix clematidis floridae or polyphyll Radix clematidis floridae.Containing hederagenin.There is diuresis, dredging collateral, regulating the flow of QI to relieve constipation, effect of removing toxic substances.For rheumatic arthritis, dysuria, amenorrhea, constipation abdominal distention, acute toothache, eye plays punctate keratitis, worm venom, jaundice.
Cacumen Platycladi: bitter in the mouth, puckery, cold in nature.Return lung, liver, spleen channel.For the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi.There is cooling blood for hemostasis, effect of growing and blacking hair.For hematemesis and epistaxis, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair.
Caulis Bauhiniae Championii: bitter in the mouth, cold in nature.Return lung meridian.For root or the leaf of Menispermaceae Cyclea plant iron rattan.The root of ferrum rattan contains isochondodendrine, left-handed curare alkaloid, berbamine, Cyclanoline and magnoflorine.There is heat-clearing and toxic substances removing, effect of promoting urination and stopping pain.For pharyngolaryngitis, diphtheria, tonsillitis, urinary tract infection and calculus, toothache, stomachache, rheumatic arthralgia; External treatment carbuncle skin ulcer, innominate toxic swelling, venom.
Photiniaserrulata: acrid in the mouth, hardship, property is put down.Return liver, kidney channel.For leaf or the band leaf twig of Rosaceae Photinia plant Chinese photinia.Leaf, branch cyanogenetic glycoside, do not contain in root.Leaf is containing free hydrocyanic acid, and its changes of contents is comparatively large, is about 0.015%-0.120%; Another containing wild cherry skin glycoside, obtain glucose, benzaldehyde and hydrocyanic acid after hydrolysis.There is wind-damp dispelling, antipruritic, bone and muscle strengthening, effect of liver and kidney tonifying.For rheumatic arthralgia, wind syndrome of head is had a headache, rubella, flaccidity of feet and knees, lumbago due to renal deficiency, sexual impotence, seminal emission.
Cortex erythrinae: bitter in the mouth, pungent, property is put down.Return liver, spleen channel.For dried bark or the root bark of pulse family coral tree erythrina indica, Erythrinae Arborescentis.Containing alkaloid: erysovine alkali, stachydrine, the special alkali of erythrina indica, erysodine, erythraline, erysopine, an erythrina indica booth alkali, erythrina indica dienone alkali, erysonine alkali, hypaphorine, erythratine alkali, erythratidine alkali, different erythratidine alkali, 11-hydroxyl table erythratidine alkali.There is expelling wind and removing dampness, channels sootheing and network vessel quickening, effect of killing parasites for relieving itching.For rheumatic arthralgia, podomere contracture, traumatic injury, scabies, eczema.
Large Ye Nansu: bitter in the mouth, micro-sweet, cool in nature.For the Herb of the large Ye Nansu of Araeceae Rhaphidophora plant.There is eliminating stasis to stop pain, relaxing muscles and tendons and activating QI and blood in the collateral, effect of nourishing the lung to arrest cough.For angina pectoris, treating swelling and pain by traumatic injury, fracture, rheumatalgia, numb limbs and tense tendons, bronchitis, pertussis.
Herba Ecliptae: sweet in the mouth, acid, cold in nature.Return kidney, Liver Channel.For the dry aerial parts of feverfew Eclipta prostrata.There is nourishing the liver and kidney, effect of cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
embodiment 1treat a Chinese medicine composition for gout, take off and state primary raw material and be prepared from (getting 50g for every part): Fructus Ligustri Lucidi 12 parts; Rhizoma Smilacis Chinensis 8 parts; 10 parts, Caulis et Folium Lini; Radix Dipsaci 7 parts; Rhizoma et Radix Dysosmae Veitchii 9 parts; 6 parts, pallet; Mangnolia officinalis 12 parts; Celastrus aceleatus Merr 9 parts; Radix clematidis floridae 13 parts; Cacumen Platycladi 8 parts; Caulis Bauhiniae Championii 10 parts; Photiniaserrulata 7 parts; Cortex erythrinae 9 parts; great Ye south Soviet Union 8 parts; Herba Ecliptae 11 parts.
Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition pill of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly is clean, moistening 13 minutes, puts in cage, steams 35 minutes, and moistening is to saturating, and shave while hot, dry, pulverize, and crosses 170 mesh sieves;
(3) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, put into Fructus Ligustri Lucidi when moderate heat is heated to meter Mao Yan, stir medical material gently, moderate heat fries 25 minutes, and sieve removes rice, cools, porphyrize, crosses 170 mesh sieves;
(4) Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 50 minutes, add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 35 minutes, twice filtrate merges, and adds step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.15(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;
(5) be placed in pot by Mel, slow fire is tempered and is endured to thick to Mel, mixes step (4) gained medicated powder, fully mixes into ointment thoroughly, makes by the traditional Chinese medical science tradition pill method pill that diameter is 4mm.
Instructions of taking: each 7 balls, every day 2 times, 5 days courses for the treatment of.
embodiment 2treat a Chinese medicine composition for gout, take off and state primary raw material and be prepared from (getting 60g for every part): Fructus Ligustri Lucidi 16 parts; Rhizoma Smilacis Chinensis 13 parts; 14 parts, Caulis et Folium Lini; Radix Dipsaci 12 parts; Rhizoma et Radix Dysosmae Veitchii 15 parts; 10 parts, pallet; Mangnolia officinalis 16 parts; Celastrus aceleatus Merr 14 parts; Radix clematidis floridae 18 parts; Cacumen Platycladi 15 parts; Caulis Bauhiniae Championii 16 parts; Photiniaserrulata 11 parts; Cortex erythrinae 16 parts; great Ye south Soviet Union 14 parts; Herba Ecliptae 15 parts.
Above-mentioned a kind of preparation method for the treatment of the Chinese medicinal composition capsules of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly is clean, moistening 13 minutes, puts in cage, steams 35 minutes, and moistening is to saturating, and shave while hot, dry, pulverize, and crosses 170 mesh sieves;
(3) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, put into Fructus Ligustri Lucidi when moderate heat is heated to meter Mao Yan, stir medical material gently, moderate heat fries 25 minutes, and sieve removes rice, cools, porphyrize, crosses 170 mesh sieves;
(4) Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 50 minutes, add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 35 minutes, twice filtrate merges, and adds step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.15(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;
(5) step (4) gained medicated powder is made capsule by the specification of 0.5g/ grain.
Instructions of taking: each 2, every day 2 times, 5 days courses for the treatment of.
model case one:bent XX, man, 45 years old, people from Yantai City.Find that uric acid level is higher in worker's health check-up more than a year, also there is no other malaise symptoms at that time, so also do not notice very much.After result about half a year, toe joint starts to occur pain and swelling, even can walk lamely time serious, symptom after taking medicine is alleviated, but occurs again heel break-through pain after half wheat harvesting period, slight swelling, tenderness (+), removes examination in hospital: uric acid 528 umol/L, is diagnosed as gout.Corresponding treatment is after one month, remission, but recurrent exerbation always, fails recovery from illness.
After taking the present invention a kind of 2 courses for the treatment of of Chinese medicine composition for the treatment of gout, pain relief, toes swell and ache and alleviate, walking freely, without walking lamely.After continuing to take 2 courses for the treatment of, all malaise symptoms disappear, and blood uric acid reduces to 268umol/L.Follow up a case by regular visits to and within 1 year, learn and fully recover, do not recur.
embodiment 3treat a Chinese medicine composition for gout, take off and state primary raw material and be prepared from (getting 40g for every part): Fructus Ligustri Lucidi 13 parts; Rhizoma Smilacis Chinensis 10 parts; 11 parts, Caulis et Folium Lini; Radix Dipsaci 9 parts; Rhizoma et Radix Dysosmae Veitchii 11 parts; 7 parts, pallet; Mangnolia officinalis 13 parts; Celastrus aceleatus Merr 11 parts; Radix clematidis floridae 14 parts; Cacumen Platycladi 11 parts; Caulis Bauhiniae Championii 12 parts; Photiniaserrulata 8 parts; Cortex erythrinae 12 parts; great Ye south Soviet Union 10 parts; Herba Ecliptae 12 parts.
Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition oral liquid of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly is clean, moistening 13 minutes, puts in cage, steams 35 minutes, and moistening is to saturating, and shave while hot, dry, pulverize, and crosses 170 mesh sieves;
(3) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, put into Fructus Ligustri Lucidi when moderate heat is heated to meter Mao Yan, stir medical material gently, moderate heat fries 25 minutes, and sieve removes rice, cools, porphyrize, crosses 170 mesh sieves;
(4) Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 50 minutes, add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 35 minutes, twice filtrate merges, and adds step (2)-(3) gained powder, mixing, filter, add simple syrup, mixing, high temperature sterilization 15 minutes, carries out sterile packaged with the specification of often propping up 6ml.
Instructions of taking: each one, every day 2 times, 5 days courses for the treatment of.
embodiment 4treat a Chinese medicine composition for gout, take off and state primary raw material and be prepared from (getting 20g for every part): Fructus Ligustri Lucidi 15 parts; Rhizoma Smilacis Chinensis 12 parts; 13 parts, Caulis et Folium Lini; Radix Dipsaci 11 parts; Rhizoma et Radix Dysosmae Veitchii 13 parts; 9 parts, pallet; Mangnolia officinalis 15 parts; Celastrus aceleatus Merr 13 parts; Radix clematidis floridae 16 parts; Cacumen Platycladi 13 parts; Caulis Bauhiniae Championii 14 parts; Photiniaserrulata 10 parts; Cortex erythrinae 14 parts; great Ye south Soviet Union 12 parts; Herba Ecliptae 14 parts.
Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition syrup of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly is clean, moistening 13 minutes, puts in cage, steams 35 minutes, and moistening is to saturating, and shave while hot, dry, pulverize, and crosses 170 mesh sieves;
(3) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, put into Fructus Ligustri Lucidi when moderate heat is heated to meter Mao Yan, stir medical material gently, moderate heat fries 25 minutes, and sieve removes rice, cools, porphyrize, crosses 170 mesh sieves;
(4) Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 50 minutes, add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 35 minutes, twice filtrate merges, and adds step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.15(45 DEG C) thick paste, add sorbic acid (consumption is 0.03% of thick paste quality), mix homogeneously, sterile packaged.
Instructions of taking: each 7g, with the warm boiled water of 35-40 DEG C, every day 2 times, 5 days courses for the treatment of.
model case two:zhu XX, man, 49 years old, people from Yantai City.Before about 6 years after once drinking, there is suddenly instep and swell and ache, have difficulty in going to sleep, the scorching hot redness in local.Take pain relief after antiinflammatory paroxysmal pain medicine.Drink whenever later and namely easily show effect, gradually occur finger, toes arthralgia, night is especially serious, and finger-joint is more and more stiff, shows effect whenever and all must take analgesic, take medicine-feeding poor effect in recent years.So remove examination in hospital, flushing, quite row, finger, instep redness, tenderness, function limitation; Chemical examination: erythrocyte sedimentation rate: 78mm/h, blood uric acid: 668umol/L.Be diagnosed as gout.After corresponding treatment, pain is alleviated to some extent, but always recurrent exerbation, time light time heavy, fail radical cure always.
After taking the present invention a kind of 2 courses for the treatment of of Chinese medicine composition for the treatment of gout, symptoms of joint pain alleviates, and swell and ache transference cure, and two wrist, both hands, two knee joint pain disappear.After continuing to take 2 courses for the treatment of, in walking freely, pain symptom disappears.Later stage visits and within 1 year, learns and fully recover, and does not also recur again.
embodiment 5treat a Chinese medicine composition for gout, take off and state primary raw material and be prepared from (getting 20g for every part): Fructus Ligustri Lucidi 14 parts; Rhizoma Smilacis Chinensis 11 parts; 12 parts, Caulis et Folium Lini; Radix Dipsaci 10 parts; Rhizoma et Radix Dysosmae Veitchii 12 parts; 8 parts, pallet; Mangnolia officinalis 14 parts; Celastrus aceleatus Merr 12 parts; Radix clematidis floridae 15 parts; Cacumen Platycladi 12 parts; Caulis Bauhiniae Championii 13 parts; Photiniaserrulata 9 parts; Cortex erythrinae 13 parts; great Ye south Soviet Union 11 parts; Herba Ecliptae 13 parts.
Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition tablet of gout, step is as follows:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly is clean, moistening 13 minutes, puts in cage, steams 35 minutes, and moistening is to saturating, and shave while hot, dry, pulverize, and crosses 170 mesh sieves;
(3) pot is burnt heat, sprinkle the rice soaked, make on its smooth pot, put into Fructus Ligustri Lucidi when moderate heat is heated to meter Mao Yan, stir medical material gently, moderate heat fries 25 minutes, and sieve removes rice, cools, porphyrize, crosses 170 mesh sieves;
(4) Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 50 minutes, add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 35 minutes, twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, being concentrated into relative density is 1.15(45 DEG C) thick paste, granulate, tabletting, dries, sugar coating.
Instructions of taking: each 2, every day 2 times, 5 days courses for the treatment of.
test example:for a kind of examination of curative effect for the treatment of the Chinese medicine composition (embodiment 5) of gout of the present invention, we have done toxicity test and clinical trial, and concrete condition is as follows:
toxicity test acute toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.Carry out disinfection to the feeding room, cage tool, drinking bottle etc. of mice before raising, before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, ensure female not producing, without pregnant.Gastric perfusion needle is used to carry out gavage to mice: to be diluted by a kind of for the present invention Chinese medicine composition warm water for the treatment of gout, gastric perfusion needle is inserted by animal bicker, general depth of needle 2.5-3cm, every mouse stomach 0.3ml medicinal liquid, the reaction of close observation mice after administration, observes 15 days, and experimental animal does not find poisoning manifestations, without dead, dissect obviously not abnormal, judge that a kind of Chinese medicine composition acute toxicity for the treatment of gout of the present invention belongs to nontoxic level.
long term toxicity testselect SPF level kunming mice, raise in square transparent mouse cage, the drinking-water that guarantee is sufficient and food, raise 2-3 days before experiment, to adapt to experimental situation, and observes its normal growth activity and health status.Before raising, the feeding room, cage tool, drinking bottle etc. of mice are carried out disinfection.Before administration, fasting can't help water 12 hours.Select the mice 20 of normal health, male and female half and half, body weight 18-22g, same guarantee is female does not produce, without pregnant.Take a kind of Chinese medicine composition for the treatment of gout of the present invention, dilute with warm water, every mice controls dosage 1g every day, continuous use 7 weeks, and drug withdrawal was observed after 3 weeks, weigh weekly once during administration, can be observed amount of drinking water appetite all normal, body weight increases, without dead or moribund animals, the index such as hair, behavior, defecation, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of mice all has no significant effect, and internal organs naked eyes do not find difference change.Histological indications shows, medication 7 weeks and drug withdrawal be after 3 weeks, and Organs of Mice is all without obviously changing, and after illustrating that the present invention is a kind of and treating the Chinese medicine composition long-term prescription of gout, toxicity is very little, does not also have difference to react, application safety after drug withdrawal.
clinical trial:in order to verify a kind of curative effect for the treatment of the Chinese medicine composition of gout of the present invention, We conducted contrast test.Experiment sieving patient with gout 220 people, is divided into matched group and experimental group randomly, and wherein experimental group has 150 people, and matched group has 70 people.
Diagnostic criteria: 1. joint fluid has special urate crystal; 2. chemically or polarizing microscope confirm to have the tophus of urate crystal; 3. there is following clinical, laboratory and X line and take the photograph at least 6: the A in sheet sign etc. 12, once above acute arthritis outbreak; B, inflammation show in 1 day and reach peak; C, monarthritis; D, joint redness; E, the 1st metatarsophalangeal joints swell or pain; F, involve the one-sided outbreak of the 1st metatarsophalangeal joints; G, one-sided midtarsal joints are got involved; H, suspicious tophus; I, hyperuricemia; The swelling of sheet intraarticular unsymmetry taken the photograph by J, X line; K, X line is taken the photograph sheet and to be shown under cortical bone that capsule becomes and do not accompany bone rotten to the corn; L, arthritis stage of attack joint fluid microorganism culturing are negative.
Exclusion standard: the age is below 18 years old or more than 65 years old; To drug allergy person; Merge gouty nephropathy, renal insufficiency person; Merge severe primary disease and the insanes such as the heart, liver, kidney, brain and hemopoietic system; The scorching severe deformity of advanced joint, disability person; Curative effect or data not congruent affect the treatment evaluation or safety judgement person cannot be judged.
Experimental group: take a kind of Chinese medicine composition tablet for the treatment of gout of the present invention, each 2, every day 2 times, 5 days courses for the treatment of; Matched group: adopt other treatment scheme, such as benzbromarone tablets, probenecid sheet etc.Benzbromarone tablets: be grown up each oral 50mg (1), once a day, early takes after the meal, medication 1-3 weekly check serum uric acid concentration, in successive treatment, adult and youngster 50-100mg every day (1-2 sheet) of more than 14 years old, or follow the doctor's advice.Probenecid sheet: chronic gout, oral each 0.25g every day 2 times, a Zhou Houke increases to each 0.5-1g, every day 2 times, and increase the effect of penicillins, each 0.5g, every day 4 times, child 25mg/kg 3-9 every day hour once.
Criterion of therapeutical effect: recovery from illness: symptom disappears completely, joint function recovery is normal, and main physico-chemical examination index is normal.Effective: cardinal symptom disappears, and function of joint is recovered substantially, and main physico-chemical examination index makes moderate progress.Invalid: compared with before treatment, each side is all not improved.Wherein effectively comprise recovery from illness and effective.
The Comparison of therapeutic of matched group and experimental group, concrete condition is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, a kind of good effect of curative effect more than the medicine of use other treatment gout for the treatment of the Chinese medicine composition of gout of the present invention is taken.Wherein, from effective percentage, take a kind of Chinese medicine composition for the treatment of gout of the present invention up to 97.33%, and take other drug be only 82.86%; From cure rate, take a kind of cure rate for the treatment of the Chinese medicine composition of gout of the present invention up to 64.67%, and take other drug be only 41.43%.Experiment shows that a kind of Chinese medicine composition for the treatment of gout of the present invention is compared with employing other drug, and its curative effect increases substantially, and cure rate is high, and inefficiency is low, is the more satisfactory medicine for the treatment of gout, evident in efficacy.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat a Chinese medicine composition for gout, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Fructus Ligustri Lucidi 12-16 part; Rhizoma Smilacis Chinensis 8-13 part; Caulis et Folium Lini 10-14 part; Radix Dipsaci 7-12 part; Rhizoma et Radix Dysosmae Veitchii 9-15 part; Pallet 6-10 part; Mangnolia officinalis 12-16 part; Celastrus aceleatus Merr 9-14 part; Radix clematidis floridae 13-18 part; Cacumen Platycladi 8-15 part; Caulis Bauhiniae Championii 10-16 part; Photiniaserrulata 7-11 part; Cortex erythrinae 9-16 part; great Ye south Soviet Union 8-14 part; Herba Ecliptae 11-15 part.
2. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Fructus Ligustri Lucidi 13-15 part; Rhizoma Smilacis Chinensis 10-12 part; Caulis et Folium Lini 11-13 part; Radix Dipsaci 9-11 part; Rhizoma et Radix Dysosmae Veitchii 11-13 part; Pallet 7-9 part; Mangnolia officinalis 13-15 part; Celastrus aceleatus Merr 11-13 part; Radix clematidis floridae 14-16 part; Cacumen Platycladi 11-13 part; Caulis Bauhiniae Championii 12-14 part; Photiniaserrulata 8-10 part; Cortex erythrinae 12-14 part; great Ye south Soviet Union 10-12 part; Herba Ecliptae 12-14 part.
3. Chinese medicine composition according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Fructus Ligustri Lucidi 14 parts; Rhizoma Smilacis Chinensis 11 parts; 12 parts, Caulis et Folium Lini; Radix Dipsaci 10 parts; Rhizoma et Radix Dysosmae Veitchii 12 parts; 8 parts, pallet; Mangnolia officinalis 14 parts; Celastrus aceleatus Merr 12 parts; Radix clematidis floridae 15 parts; Cacumen Platycladi 12 parts; Caulis Bauhiniae Championii 13 parts; Photiniaserrulata 9 parts; Cortex erythrinae 13 parts; great Ye south Soviet Union 11 parts; Herba Ecliptae 13 parts.
4., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, this Chinese medicine composition is made pharmaceutically acceptable pill, and preparation method is:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, be concentrated into the thick paste that relative density is 1.10-1.20 and (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder,
(5) be placed in pot by Mel, slow fire is tempered and is endured to thick to Mel, mixes step (4) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferred diameter is 3-5mm, and being more preferably diameter is 4mm) by traditional Chinese medical science tradition pill method.
5. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: the consumption of the preferred Mel of step (5) is the 10%-20% of medicated powder quality, and the consumption being more preferably Mel is 15% of medicated powder quality.
6., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, this Chinese medicine composition is made pharmaceutically acceptable capsule, and preparation method is:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, be concentrated into the thick paste that relative density is 1.10-1.20 and (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), dry, pulverize, obtain medicated powder,
(5) step (4) gained medicated powder is made capsule (preferred 0.5g/ grain) by the specification of 0.4-0.6g/ grain.
7., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, this Chinese medicine composition is made pharmaceutically acceptable oral liquid, and preparation method is:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, add simple syrup, mixing, high temperature sterilization 10-20 minute (preferred high temperature sterilization 13-17 minute, be more preferably high temperature sterilization 15 minutes), sterile packaged is carried out with the specification of often propping up 6ml.
8. the preparation method of Chinese medicine composition according to claim 7, is characterized in that: the consumption of the preferred simple syrup of step (4) is the 6%-10% of quality of liquid medicine, and the consumption being more preferably simple syrup is 8% of quality of liquid medicine.
9., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, this Chinese medicine composition is made pharmaceutically acceptable syrup, and preparation method is:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, be concentrated into the thick paste that relative density is 1.10-1.20 and (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), (consumption of preferred sorbic acid is the 0.02%-0.04% of thick paste quality to add sorbic acid, the consumption being more preferably sorbic acid is 0.03% of thick paste quality), mix homogeneously, sterile packaged.
10., according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, this Chinese medicine composition is made pharmaceutically acceptable tablet, and preparation method is:
(1) smashed by Radix clematidis floridae, be placed in medicine cookeding pot, intense fire heats, and fries to pitchy, spray clear water, and go out most Mars, takes out, dry;
(2) by clean to Caulis et Folium Lini, Radix Dipsaci, pallet and Celastrus aceleatus Merr wash quickly, moistening 10-15 minute (preferred moistening 12-14 minute is more preferably moistening 13 minutes), puts in cage, steam and (preferably steam 33-37 minute in 30-40 minute, be more preferably steaming 35 minutes), moistening is extremely saturating, shave while hot, dry, pulverize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(3) pot is burnt heat, sprinkle the rice soaked, make, on its smooth pot, when moderate heat is heated to meter Mao Yan, to put into Fructus Ligustri Lucidi, stir medical material gently, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and sieve removes rice, cool, porphyrize, excessively 160-180 mesh sieve (preferred 166-174 mesh sieve excessively, was more preferably 170 mesh sieves);
(4) by Rhizoma et Radix Dysosmae Veitchii, Photiniaserrulata and large Ye Nansu are placed in marmite, decoct with water 40-60 minute and (preferably decoct 45-55 minute, be more preferably decoction 50 minutes), add step (1) gains, Rhizoma Smilacis Chinensis, Mangnolia officinalis, Cacumen Platycladi, Caulis Bauhiniae Championii, Cortex erythrinae and Herba Ecliptae, continue decoction twice, each decoction 30-40 minute (preferably each decoction 33-37 minute, be more preferably each decoction 35 minutes), twice filtrate merges, add step (2)-(3) gained powder, mixing, filter, be concentrated into the thick paste that relative density is 1.10-1.20 and (be preferably concentrated into the thick paste that relative density is 1.13-1.17, be more preferably and be concentrated into the thick paste that relative density is 1.15), granulate, tabletting, dry, sugar coating.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125599A (en) * | 2018-10-26 | 2019-01-04 | 特医科技（合肥）有限公司 | A kind of gout tea bag |
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| CN103127428A (en) * | 2013-03-27 | 2013-06-05 | 谢银芳 | Chinese patent drug for treatment of gouty arthritis |
| KR101346281B1 (en) * | 2013-08-20 | 2013-12-31 | 강영효 | Compositions for preventing, improving or treating gout, containing extracts of twenty nine medicine plants as active ingredient |
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|---|---|---|---|---|
| CN103127428A (en) * | 2013-03-27 | 2013-06-05 | 谢银芳 | Chinese patent drug for treatment of gouty arthritis |
| KR101346281B1 (en) * | 2013-08-20 | 2013-12-31 | 강영효 | Compositions for preventing, improving or treating gout, containing extracts of twenty nine medicine plants as active ingredient |
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| CN109125599A (en) * | 2018-10-26 | 2019-01-04 | 特医科技（合肥）有限公司 | A kind of gout tea bag |
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