CN104740540A - Heat-clearing and detoxifying preparation for treating appendicitis - Google Patents
Heat-clearing and detoxifying preparation for treating appendicitis Download PDFInfo
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Abstract
The invention discloses a heat-clearing and detoxifying preparation for treating appendicitis. The heat-clearing and detoxifying preparation is prepared from the following raw herbal materials in parts by mass: 13-18 parts of paris polyphylla, 11-16 parts of chickweeds, 12-18 parts of mangnolia officinalis, 10-14 parts of ixeris sonchifolia hance, 8-15 parts of uncinata spikemoss herb, 9-14 parts of patrinia scaniosaefolia, 8-15 parts of curcuma zedoary, 9-15 parts of Chinese lobelia, 9-13 parts of dried rehmannia, 13-18 parts of spanishneedles herb, 12-16 parts of peruvian groundcherry herb, 10-15 parts of dandelion, 10-16 parts of maidenhair and 13-18 parts of wild chrysanthemum flowers. The heat-clearing and detoxifying preparation completely meets the traditional Chinese medicine principle, and has the effects of clearing away heat and toxic materials, relieving swelling and pains, nourishing yin and blood and the like. The prepared product has the advantages of being quick in effect-taking, good in curative effect, and capable of preventing the appendicitis from recurring. The heat-clearing and detoxifying preparation is prepared from the traditional Chinese medicines, free of obvious toxic or side effect, safe and reliable, and can be taken at ease.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat typhlitic antipyretic-detoxicant preparation.
Background technology
Generally at outer 1/3 place of right anterior superior iliac spine to umbilicus line, claim McBurney's point herein, be mcBurney point again, during appendicitis, obvious tenderness and rebound tenderness.Appendicitis is common Abdominal Surgery, can betide the people at any age, especially more common with teenager.Often there are the performances such as the rising of right lower abdomen pain, body temperature, vomiting and neutrophilic leukocytosis clinically.Appendicitis refers to that the inflammatory that vermiform appendix formed due to many factors changes, and is surgical common disease, and whether timely its prognosis depends on Diagnosis and Treat.Early stage diagnosis and treatment, patient is many can rehabilitation in a short time; If delay diagnosis and treatment can cause serious complication, as vermiform appendix perforation causes peritonitis, even cause death.Appendicitis has acute and chronic point, and the typical clinical manifestations of acute appendicitis is dull pain around the epigastrium or umbilicus that occur gradually, and after a few hours, stomachache is transferred to right lower abdomen.Normal with inappetence, n or V, their early stage except low grade fever, weak except, how without obvious General Symptoms.Acute appendicitis, through non-operative treatment or after curing, can be left over the proliferation of fibrous tissue of vermiform appendix wall and thicken, and luminal stenosis and adhesion around, be referred to as chronic appendicitis, easily cause acute attack again.Attack times is more, and the infringement of chronic inflammatory disease is also more serious, can acute attack repeatedly, does not have symptom or occasionally have slight Right Lower Abdomen pain, so also referred to as chronic recurrent appendicitis when not showing effect.Typhlitic general clinical manifestation has nauseating, vomiting (namely stopping for 1 ~ 2 time), inappetence, abdominal distention, the symptoms such as diarrhoea.Patient likes bent knee position of bending over and lies on one's side.Some patients's fever, headache, general weakness, in blood test, total white blood cells increases.Acute appendicitis is once making a definite diagnosis, and generally take operation by the appendectomy of pathological changes, non-operative treatment generally selects antibiotic and fluid-supplement therapy.Publication No. CN 104367772 A(application number 201410649581.1) Chinese patent literature disclose one and treat chronic appendicitis medicine, by Olibanum 10-12 parts, Myrrha 10-12 parts, the Radix Aucklandiae 10-12 parts, Flos Lonicerae 10-12 parts, Herba Taraxaci 10-12 parts, Cortex Moutan 10-12 parts, Fructus Toosendan 10-12 parts, Radix Et Rhizoma Rhei 10-12 parts, Herba Bidentis Bipinnatae 10-12 parts, Herba Patriniae 10-12 parts, Rhizoma Corydalis 10-12 parts, Radix Angelicae Sinensis 10-12 parts, 10-12 parts, Semen Persicae, Herba Violae 10-12 parts, the Rhizoma Anemarrhenae 10-12 parts, 10-12 parts, Gypsum Fibrosum, Rhizoma Pinelliae Preparata 10-12 parts composition.Publication No. CN 103784542 A(application number 201210561528.7) Chinese patent literature disclose a kind of Chinese herbal medicine for the treatment of acute appendicitis, by Flos Lonicerae 35-45 part; Radix Et Rhizoma Rhei 15-25 part; Cortex Moutan 25-35 part; Semen Persicae 25-35 part; Winter is to core 20-30 part; Natrii Sulfas 15-25 part; Radix Aucklandiae 20-30 part; 35-45 part is practiced in river; Herba Taraxaci 20-35 part; Radix Paeoniae Rubra 25-35 part; Herba Pteridis Multifidae 15-25 part; Flos Rosae Chinensis 15-25 part; Add water 1900 parts to boil and form.Publication No. CN 104225095 A(application number 201410488387.X) Chinese patent literature disclose one and treat typhlitic Chinese medicine pill, crude drug consists of Radix Et Rhizoma Rhei 10 parts, 9 parts, Natrii Sulfas, Herba Violae 15 parts, Rhizoma Polygoni Cuspidati 15 parts, 9 parts, the Radix Rehmanniae, Radix Scrophulariae 9 parts, Radix Glycyrrhizae 6 parts, Herba Scutellariae Barbatae 15 parts.
Operative treatment appendicitis, risky, injury is large, and Chinese medicine is safe and reliable, and side effect is little, though more current traditional Chinese medical science formula treatment appendicitis has certain curative effect, can not reach the effect of thoroughly radical cure, curative effect is still to be improved.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare the typhlitic antipyretic-detoxicant preparation for the treatment of simple, evident in efficacy.
Technical scheme of the present invention is:
Treat typhlitic antipyretic-detoxicant preparation, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Paridis 13-18, Herba stellariae mediae 11-16, Cortex Magnoliae Officinalis 12-18, Herba Ixeritis Sonchifoliae 10-14, CUIYUNCAO 8-15, Herba Patriniae 9-14, Rhizoma Curcumae 8-15, Herba Lobeliae Chinensis 9-15, Radix Rehmanniae 9-13, Herba Bidentis Bipinnatae 13-18, Fructus Seu Herba Pubescentis 12-16, Herba Taraxaci 10-15, Herba Adianti Flabellulati 10-16, Flos Chrysanthemi Indici 13-18.
In preferred scheme, Rhizoma Paridis 14-17, Herba stellariae mediae 12-15, Cortex Magnoliae Officinalis 14-16, Herba Ixeritis Sonchifoliae 11-13, CUIYUNCAO 10-13, Herba Patriniae 11-12, Rhizoma Curcumae 10-13, Herba Lobeliae Chinensis 11-13, Radix Rehmanniae 10-12, Herba Bidentis Bipinnatae 14-17, Fructus Seu Herba Pubescentis 13-15, Herba Taraxaci 11-14, Herba Adianti Flabellulati 12-14, Flos Chrysanthemi Indici 14-17.
Be more preferably, Rhizoma Paridis 15.5, Herba stellariae mediae 13.5, Cortex Magnoliae Officinalis 15, Herba Ixeritis Sonchifoliae 12, CUIYUNCAO 11.5, Herba Patriniae 11.5, Rhizoma Curcumae 11.5, Herba Lobeliae Chinensis 12, Radix Rehmanniae 11, Herba Bidentis Bipinnatae 15.5, Fructus Seu Herba Pubescentis 14, Herba Taraxaci 12.5, Herba Adianti Flabellulati 13, Flos Chrysanthemi Indici 15.5.
The preparation method of the typhlitic antipyretic-detoxicant preparation decoction of described treatment is:
The typhlitic antipyretic-detoxicant preparation of described treatment, be made into pharmaceutically acceptable powder, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Patriniae, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati, Flos Chrysanthemi Indici are cleaned, dry, pulverize and sieve together with step (1) (2) (3) made crude drug, make medicated powder, obtain powder.
The preparation method of the typhlitic antipyretic-detoxicant preparation powder of described treatment, step (4) was pulverized 200-360 mesh sieve and (preferably, was pulverized 240-320 mesh sieve; Be more preferably, pulverized 280 mesh sieves).
The typhlitic antipyretic-detoxicant preparation of described treatment, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Cortex Magnoliae Officinalis, Herba Patriniae, Radix Rehmanniae are pulverized together with step (1) (2) made crude drug 120-180 mesh sieve and (preferably, pulverize 140-160 mesh sieve; Be more preferably, pulverized 150 mesh sieves), obtained medicated powder;
(4) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(5) Herba stellariae mediae, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Lobeliae Chinensis, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati and Flos Chrysanthemi Indici are cleaned, put into non iron container together with step (4) made crude drug, add the water soaking 26 minutes of boiled crude drug quality 7 times, big fire is heated to boiling, be adjusted to little fire to decoct, then filter, filtering residue adds water and again decocts, and filters, merge twice gained filtrate, and add step (3) made medicated powder, stir evenly, obtain decoction.
The preparation method of the typhlitic antipyretic-detoxicant preparation decoction of described treatment, step (5) be adjusted to little fire decoct 16-24 minute (preferred, be adjusted to little fire and decoct 18-22 minute; Be more preferably, be adjusted to little fire and decoct 20 minutes).
The typhlitic antipyretic-detoxicant preparation of described treatment, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Patriniae, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati, Flos Chrysanthemi Indici are pulverized and sieved together with step (1) (2) (3) made crude drug, make medicated powder, made medicated powder is (preferred according to the metering of 0.25-0.35g/ sheet, according to the metering of 0.30g/ sheet), suppress conglobate tablet dosage form according to the preparation for processing of tablet.
The preparation method of the typhlitic antipyretic-detoxicant preparation tablet of described treatment, step (4) was pulverized 90-200 mesh sieve and (preferably, was pulverized 120-170 mesh sieve; Be more preferably, pulverized 150 mesh sieves).
The typhlitic antipyretic-detoxicant preparation of described treatment, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, Herba Patriniae, CUIYUNCAO, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati and Flos Chrysanthemi Indici are cleaned, non iron container is put into together with step (1) (2) (3) made crude drug, soak 26 minutes, big fire is heated to boiling, be adjusted to little fire decoct 20-30 minute (preferred, be adjusted to little fire and decoct 22-28 minute; Be more preferably, be adjusted to little fire and decoct 25 minutes), then filter, filtering residue adds water and again decocts, and filters, merges twice gained filtrate, and heating is condensed into paste, adds refined honey and stirs evenly, obtain soft extract.
The preparation method of the typhlitic antipyretic-detoxicant preparation soft extract of described treatment, step (4) twice amount of water is the 7-9 of crude drug gross mass doubly (preferred, twice amount of water is 8 times of crude drug gross mass).
The typhlitic antipyretic-detoxicant preparation for the treatment of provided by the invention obtains through the summary of experience of clinical practice for many years, and medicine source is cheap and easy to get, and preparation is simple.In addition, excellent results of the present invention also shows:
1, prescription of the present invention meets Chinese medicine principle completely, has the effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, nourishing YIN and benefiting blood;
2, products made thereby of the present invention has the advantages such as instant effect, good effect, anti-recurrence;
3, the present invention is that Chinese medicine material is made, without obvious toxic-side effects, safe and reliable, can relievedly take.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat typhlitic antipyretic-detoxicant preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Paridis 13 parts, Herba stellariae mediae 11 parts, Cortex Magnoliae Officinalis 12 parts, Herba Ixeritis Sonchifoliae 10 parts, CUIYUNCAO 8 parts, Herba Patriniae 9 parts, Rhizoma Curcumae 8 parts, Herba Lobeliae Chinensis 9 parts, Radix Rehmanniae 9 parts, Herba Bidentis Bipinnatae 13 parts, Fructus Seu Herba Pubescentis 12 parts, Herba Taraxaci 10 parts, Herba Adianti Flabellulati 10 parts, Flos Chrysanthemi Indici 13 parts.
The preparation method of the typhlitic antipyretic-detoxicant preparation powder of above-mentioned treatment is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Patriniae, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati, Flos Chrysanthemi Indici are cleaned, dry, pulverized 280 mesh sieves together with step (1) (2) (3) made crude drug, make medicated powder, obtain powder.
embodiment 2treat typhlitic antipyretic-detoxicant preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Paridis 18 parts, Herba stellariae mediae 16 parts, Cortex Magnoliae Officinalis 18 parts, Herba Ixeritis Sonchifoliae 14 parts, CUIYUNCAO 15 parts, Herba Patriniae 14 parts, Rhizoma Curcumae 15 parts, Herba Lobeliae Chinensis 15 parts, Radix Rehmanniae 13 parts, Herba Bidentis Bipinnatae 18 parts, Fructus Seu Herba Pubescentis 16 parts, Herba Taraxaci 15 parts, Herba Adianti Flabellulati 16 parts, Flos Chrysanthemi Indici 18 parts.
The preparation method for the treatment of typhlitic antipyretic-detoxicant preparation decoction is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Cortex Magnoliae Officinalis, Herba Patriniae, Radix Rehmanniae were pulverized 150 mesh sieves together with step (1) (2) made crude drug, obtained medicated powder;
(4) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(5) Herba stellariae mediae, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Lobeliae Chinensis, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati and Flos Chrysanthemi Indici are cleaned, put into non iron container together with step (4) made crude drug, add the water soaking 26 minutes of boiled crude drug quality 7 times, big fire is heated to boiling, be adjusted to little fire and decoct 20 minutes, then filter, filtering residue adds water and again decocts, and filters, merge twice gained filtrate, and add step (3) made medicated powder, stir evenly, obtain decoction.
Model case: xxx, man, 26 years old.Main suit: before one day, has drunk one glass of cold drink when going window-shopping with friend, occur paroxysmal abdominal pain afterwards, diarrhoea also with feeling sick, starts heating, vomiting evening, Sui Zhi community outpatient service treatment, tentatively be judged as acute gastroenteritis, and treat, after taking medicine, symptom is not improved, stomachache aggravation, and body temperature rises to 38.5 DEG C, stomachache transfers right lower abdomen to, and then check to provincial hospital, Right Lower Abdomen mcBurney point tenderness is obvious, without obvious muscle tonus, leukocyte count 22.4 × 10
9/ L, is diagnosed as acute suppurative appendicitis.
Take the present embodiment gained and treat typhlitic antipyretic-detoxicant preparation decoction, every day 3 times, each 200-300ml(is warm), 7 days courses for the treatment of.After taking 1 day, Right Lower Abdomen pain relief, temperature recovery is normal, and diarrhoea number of times reduces, after taking 4 days, Right Lower Abdomen pain disappears substantially, and other symptoms disappear completely, and after taking a course for the treatment of, patient is without sense of discomfort, a course for the treatment of of consolidate curative effect, patient fully recovers, and follow up a case by regular visits in 3 years, patient is not recurred.
embodiment 3treat typhlitic antipyretic-detoxicant preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Paridis 14 parts, Herba stellariae mediae 12 parts, Cortex Magnoliae Officinalis 14 parts, Herba Ixeritis Sonchifoliae 11 parts, CUIYUNCAO 10 parts, Herba Patriniae 11 parts, Rhizoma Curcumae 10 parts, Herba Lobeliae Chinensis 11 parts, Radix Rehmanniae 10 parts, Herba Bidentis Bipinnatae 14 parts, Fructus Seu Herba Pubescentis 13 parts, Herba Taraxaci 11 parts, Herba Adianti Flabellulati 12 parts, Flos Chrysanthemi Indici 14 parts.
The preparation method for the treatment of typhlitic antipyretic-detoxicant preparation tablet is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Patriniae, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati, Flos Chrysanthemi Indici were pulverized 150 mesh sieves together with step (1) (2) (3) made crude drug, make medicated powder, by made medicated powder according to the metering of 0.30g/ sheet, suppress conglobate tablet dosage form according to the preparation for processing of tablet.
Model case: xxx, female, 33 years old.Before 4 days without obvious inducement appearance umbilicus week dull pain, in persistence, after be transferred to right lower abdominal pain 3 days, self-induction mild nausea, without diarrhoea, abdominal distention, heating, vomiting, shiver with cold etc. malaise symptoms, eat antibiotic medicine, symptom is not alleviated, then medical check, Right Lower Abdomen tenderness is obvious, especially attaches most importance to mcBurney point, bottom right abdominal muscle is slightly nervous, there is slight rebound tenderness, do not lay one's hand on and enclosed mass, be diagnosed as acute suppurative appendicitis and localized peritonitis.
Take the present embodiment gained and treat typhlitic antipyretic-detoxicant preparation tablet, adopt every day three times, each 4, with warm water delivery service, 7 days courses for the treatment of.After taking 2 days, patient suffers from abdominal pain and obviously alleviates, and after taking a course for the treatment of, stomachache malaise symptoms disappears completely, and patient fully recovers, and consolidate after taking a course for the treatment of, follow up a case by regular visits in two years, patient is not recurred.
embodiment 4treat typhlitic antipyretic-detoxicant preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Paridis 17 parts, Herba stellariae mediae 15 parts, Cortex Magnoliae Officinalis 16 parts, Herba Ixeritis Sonchifoliae 13 parts, CUIYUNCAO 13 parts, Herba Patriniae 12 parts, Rhizoma Curcumae 13 parts, Herba Lobeliae Chinensis 13 parts, Radix Rehmanniae 12 parts, Herba Bidentis Bipinnatae 17 parts, Fructus Seu Herba Pubescentis 15 parts, Herba Taraxaci 14 parts, Herba Adianti Flabellulati 14 parts, Flos Chrysanthemi Indici 17 parts.
The preparation method for the treatment of typhlitic antipyretic-detoxicant preparation soft extract is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, Herba Patriniae, CUIYUNCAO, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati and Flos Chrysanthemi Indici are cleaned, non iron container is put into together with step (1) (2) (3) made crude drug, add the water soaking 26 minutes of crude drug gross mass 8 times, big fire is heated to boiling, be adjusted to little fire and decoct 25 minutes, then filter, the water that filtering residue adds crude drug gross mass 8 times decocts again, filter, merge twice gained filtrate, heating is condensed into paste, adds refined honey and stirs evenly, obtain soft extract.
Model case: xxx, female, 54 years old.Once suffered from acute appendicitis before 4 years, after take folk prescription and cure, even between 4 years have slight Right Lower Abdomen pain, can stand, nearly 3 days, Right Lower Abdomen pain increased the weight of, with inappetence, abdominal distention, and laxativeness, medical check, Right Lower Abdomen muscle tonus, has obvious tenderness, rebound tenderness, especially be work with mcBurney point, do not touch enclosed mass, routine blood test WBC is higher, is diagnosed as chronic recurrent appendicitis.
Take the present embodiment gained and treat typhlitic antipyretic-detoxicant preparation soft extract, adopt every day three times, each 10-12ml, with warm boiled water, 7 days courses for the treatment of.After taking 2 days, right lower abdominal pain alleviates, and diarrhoea is eliminated, and after taking 5 days, patient's right lower abdominal pain obviously alleviates, appetite strengthens, and after taking a course for the treatment of, patient's Right Lower Abdomen disappears, and consolidates a course for the treatment of, patient body is in good condition, Rehabilitation, follows up a case by regular visits in 3 years, and the state of an illness is not more repeatedly.
embodiment 5treat typhlitic antipyretic-detoxicant preparation, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Paridis 15.5 parts, Herba stellariae mediae 13.5 parts, Cortex Magnoliae Officinalis 15 parts, Herba Ixeritis Sonchifoliae 12 parts, CUIYUNCAO 11.5 parts, Herba Patriniae 11.5 parts, Rhizoma Curcumae 11.5 parts, Herba Lobeliae Chinensis 12 parts, Radix Rehmanniae 11 parts, Herba Bidentis Bipinnatae 15.5 parts, Fructus Seu Herba Pubescentis 14 parts, Herba Taraxaci 12.5 parts, Herba Adianti Flabellulati 13 parts, Flos Chrysanthemi Indici 15.5 parts.
The preparation method for the treatment of typhlitic antipyretic-detoxicant preparation powder is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Patriniae, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati, Flos Chrysanthemi Indici are cleaned, dry, pulverized 280 mesh sieves together with step (1) (2) (3) made crude drug, make medicated powder, obtain powder.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Paridis: base is former: be the rhizome of liliaceous plant tool handle Rhizoma Paridis tetraphyllae.Nature and flavor: bitter, are slightly cold; Slightly poisonous.Gui Jing: return Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.For furuncle carbuncle, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, convulsion with spasms.
Herba stellariae mediae: base is former: ashlar bamboo trembles stem, the leaf of plant Herba stellariae mediae.Nature and flavor: sweet, sour, cool.Function cures mainly: heat-clearing and toxic substances removing, blood-activating analgetic, lactogenic.For enteritis, dysentery, hepatitis, appendicitis, postnatal blood stasis is suffered from abdominal pain, uterine contraction pain, toothache, early whitening of hair, agalactia, mastitis, traumatic injury, sore swollen toxin.
Cortex Magnoliae Officinalis: base is former: be bark or the root bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils..Nature and flavor: bitter, pungent, temperature.Gui Jing: return spleen, stomach, lung, large intestine channel.Function cures mainly: dampness expectorant, and the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Herba Ixeritis Sonchifoliae: base is former: be the raw then seedling of feverfew Herba Ixeritis Sonchifoliae.Nature and flavor: bitter, pungent are flat.Function cures mainly: heat-clearing and toxic substances removing, evacuation of pus, pain relieving.Appendicitis curing, enteritis, dysentery, various suppurative inflammation, spits blood, epistaxis, headache, toothache, breast, stomachache, impetigo, hemorrhoid.
CUIYUNCAO: base is former: be the herb of Spikemoss plant CUIYUNCAO.Nature and flavor: micro-hardship, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances, repercussive, hemostasis.Harness the Yellow River subcutaneous ulcer, dysentery, edema, rheumatic arthralgia, cough is spitted blood, retropharyngeal abscess, anal fistula, knife injury, scalds.
Herba Patriniae: base is former: be the whole herb with root of Valerianaceae plant patrima villosa, Patrinia scabiosaefolia Fisch or its kindred plant.Nature and flavor: bitter are flat.Gui Jing: enter liver, stomach, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Control acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain, carbuncle scabies.
Rhizoma Curcumae: base is former: be the rhizome of zingiberaceous plant Rhizoma Curcumae.Nature and flavor: bitter, pungent, temperature.Gui Jing: enter liver, spleen channel.Function cures mainly: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.
Herba Lobeliae Chinensis: base is former: be the whole herb with root of Campanulaceae Herba Lobeliae Chinensis.Nature and flavor: sweet are flat.Gui Jing: GUIXIN, small intestinal, lung meridian.Function cures mainly: diuretic, detumescence, and removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, tympanites, has loose bowels, dysentery, snakebite, furuncle, toxic swelling, eczema, and tinea disease, osteopatia sprain swells and ache.For extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting, advanced schistosomiasis ascites.
Radix Rehmanniae: base is former: be the rhizome of scrophulariaceae rehmannia glutinosa plant.Nature and flavor: sweet, bitter, cold.Gui Jing: enter the heart, liver, kidney channel.Function cures mainly: YIN nourishing, nourishes blood.Control fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon hinders constipation.
Herba Bidentis Bipinnatae: base is former: be the herb of feverfew Herba Bidentis Bipinnatae.Nature and flavor: property is put down, bitter in the mouth.Function cures mainly: heat-clearing and toxic substances removing, antidiarrheal.For enteritis, diarrhea, appendicitis, flu pharyngalgia, hepatitis, snake bite and insect sting.
Fructus Seu Herba Pubescentis: base is former: be the Herb of eggplant kind of plant Fructus Seu Herba Pubescentis.Nature and flavor: sweet, light, are slightly cold.Function cures mainly: heat clearing away, circulation of qi promoting, pain relieving, detumescence.Cure cold, mumps, laryngalgia, cough, abdominal distention, hernia, pemphigus.
Herba Taraxaci: base is former: be the whole herb with root of feverfew Herba Taraxaci.Nature and flavor: bitter, sweet, cold.Gui Jing: enter liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Herba Adianti Flabellulati: base is former: be herb or the rhizome of adiantaceae plant flabellum venushair fern.Nature and flavor: bitter, pungent, cool.Function cures mainly: heat clearing away, dampness removing, repercussive, loose swollen.Control acute infectious hepatitis, dysentery, diarrhoea, sand Stranguria, spit blood, have blood in stool, scrofula, traumatic injury, scald, traumatic hemorrhage, furuncle.
Flos Chrysanthemi Indici: base is former: be the head inflorescence of feverfew Herba Dendranthematis indici, HERBA CHRYSANTHEMI LAVANDULAEFOLII or lavandulaleaf dendranthema herb.Nature and flavor: bitter, pungent, are slightly cold.Gui Jing: return liver, heart channel.Function cures mainly: heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, has a headache dizzy.
test example 1gained of the present invention treats the clinical practice of typhlitic antipyretic-detoxicant preparation (embodiment 5):
In October ,-2014 in February, 2013, in 4 hospital outpatient case history, filter out 336 examples be diagnosed as typhlitic patient as object of study, wherein women 170 example, male 166 example, age 20-65 year, 43.7 ± 5.1 years old mean age, course of disease 1-10d.Wherein acute appendicitis 216 example, chronic appendicitis 120 example.The clinical manifestation of experimenter is in persistence, upper abdominal pain is with paroxysmal aggravation or pain around the navel companion tractive right lower abdominal pain, mcBurney point has tenderness, rebound tenderness, body temperature 37.6-38.7 DEG C or without heating, some patients with nausea,vomiting,diarrhea, total white blood cells (WBC) 10.0 × 10
9/ L-15 × 10
9/ L, the tight loud or floating number of slow pulse, red tongue, yellow and greasy fur or yellow rough, is all diagnosed as appendicitis through surgery.
Patient is divided into two groups at random, experimental group 186 example and matched group 150 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Experimental group is taken gained of the present invention and is treated typhlitic antipyretic-detoxicant preparation powder, taken three times a day, each 4-6g(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of, matched group takes other medicine (conventional medication such as appendicitis tablet, ZHONGJIEFENG PIAN, anti appendicitis ball).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.After treating 4 courses for the treatment of, add up two groups of patient treatment situations.After 1 year, statistics recurrence.
Curative effect situation criterion: cure: whole body and local discomfort symptom disappear completely, body temperature and numeration of leukocyte recover normal, and Right Lower Abdomen mcBurney point tenderness disappears, and confirm through ultrasound diagnosis, and right lower-abdominal mass disappears, and does not recur in 1 year; Effective: malaise symptoms disappears substantially, body temperature and numeration of leukocyte recover normal, the light tenderness of Right Lower Abdomen mcBurney point, confirm that right lower-abdominal mass obviously reduces through ultrasound diagnosis; Effective: malaise symptoms alleviates, body temperature fluctuation, but be no more than 38 DEG C, numeration of leukocyte a little more than normal value, Right Lower Abdomen mcBurney point tenderness, but without rebound tenderness agent muscle tonus, confirm through ultrasound diagnosis, right lower-abdominal mass reduces; Invalid: whole body and local discomfort symptom are without improvement, and B ultrasonic display lump is without obvious change.
Table 1 liang group patient treatment outcome
Relatively two groups of therapeutic outcomes (seeing table 1) are known: experimental group cures 84 examples, effective 68 examples, effective 29 examples, and total effective rate is 97.3%, cures 28 examples in matched group, effective 45 examples, effective 48 examples, and total effective rate is 80.7%, experimental group curative effect apparently higher than matched group (
p< 0.01), significant difference.Treatments period, all there is not any untoward reaction in both patients.
The Rhizoma Paridis of reducing swelling and alleviating pain is had, the Herba stellariae mediae of heat-clearing and toxic substances removing, Herba Patriniae and Flos Chrysanthemi Indici, the Cortex Magnoliae Officinalis of dampness expectorant in formula of the present invention, the Herba Ixeritis Sonchifoliae of evacuation of pus pain relieving, the CUIYUNCAO of clearing away heat-damp and promoting diuresis, the Rhizoma Curcumae of removing blood stasis circulation of qi promoting, the Herba Lobeliae Chinensis of inducing diuresis to remove edema, the Radix Rehmanniae of nourishing YIN and benefiting blood, the Herba Bidentis Bipinnatae of clearing away heat to stop diarrhea, the Fructus Seu Herba Pubescentis of heat clearing away circulation of qi promoting, the Herba Taraxaci of diuresis eliminating stagnation, the Herba Adianti Flabellulati of clearing away heat-damp and promoting diuresis, multiple effective material share, work in coordination with and play a role, play the effects such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, nourishing YIN and benefiting blood altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat typhlitic antipyretic-detoxicant preparation, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Paridis 13-18, Herba stellariae mediae 11-16, Cortex Magnoliae Officinalis 12-18, Herba Ixeritis Sonchifoliae 10-14, CUIYUNCAO 8-15, Herba Patriniae 9-14, Rhizoma Curcumae 8-15, Herba Lobeliae Chinensis 9-15, Radix Rehmanniae 9-13, Herba Bidentis Bipinnatae 13-18, Fructus Seu Herba Pubescentis 12-16, Herba Taraxaci 10-15, Herba Adianti Flabellulati 10-16, Flos Chrysanthemi Indici 13-18.
2. the typhlitic antipyretic-detoxicant preparation for the treatment of as claimed in claim 1, it is characterized in that, Rhizoma Paridis 14-17, Herba stellariae mediae 12-15, Cortex Magnoliae Officinalis 14-16, Herba Ixeritis Sonchifoliae 11-13, CUIYUNCAO 10-13, Herba Patriniae 11-12, Rhizoma Curcumae 10-13, Herba Lobeliae Chinensis 11-13, Radix Rehmanniae 10-12, Herba Bidentis Bipinnatae 14-17, Fructus Seu Herba Pubescentis 13-15, Herba Taraxaci 11-14, Herba Adianti Flabellulati 12-14, Flos Chrysanthemi Indici 14-17 is (preferred, Rhizoma Paridis 15.5, Herba stellariae mediae 13.5, Cortex Magnoliae Officinalis 15, Herba Ixeritis Sonchifoliae 12, CUIYUNCAO 11.5, Herba Patriniae 11.5, Rhizoma Curcumae 11.5, Herba Lobeliae Chinensis 12, Radix Rehmanniae 11, Herba Bidentis Bipinnatae 15.5, Fructus Seu Herba Pubescentis 14, Herba Taraxaci 12.5, Herba Adianti Flabellulati 13, Flos Chrysanthemi Indici 15.5).
3. the typhlitic antipyretic-detoxicant preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Patriniae, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati, Flos Chrysanthemi Indici are cleaned, dry, pulverize and sieve together with step (1) (2) (3) made crude drug, make medicated powder, obtain powder.
4. the preparation method of the typhlitic antipyretic-detoxicant preparation powder for the treatment of as claimed in claim 3, is characterized in that, step (4) was pulverized 200-360 mesh sieve and (preferably, pulverized 240-320 mesh sieve; Be more preferably, pulverized 280 mesh sieves).
5. the typhlitic antipyretic-detoxicant preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Cortex Magnoliae Officinalis, Herba Patriniae, Radix Rehmanniae are pulverized together with step (1) (2) made crude drug 120-180 mesh sieve and (preferably, pulverize 140-160 mesh sieve; Be more preferably, pulverized 150 mesh sieves), obtained medicated powder;
(4) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(5) Herba stellariae mediae, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Lobeliae Chinensis, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati and Flos Chrysanthemi Indici are cleaned, put into non iron container together with step (4) made crude drug, add the water soaking 26 minutes of boiled crude drug quality 7 times, big fire is heated to boiling, be adjusted to little fire to decoct, then filter, filtering residue adds water and again decocts, and filters, merge twice gained filtrate, and add step (3) made medicated powder, stir evenly, obtain decoction.
6. the preparation method of the typhlitic antipyretic-detoxicant preparation decoction for the treatment of as claimed in claim 5, is characterized in that, step (5) be adjusted to little fire decoct 16-24 minute (preferred, be adjusted to little fire and decoct 18-22 minute; Be more preferably, be adjusted to little fire and decoct 20 minutes).
7. the typhlitic antipyretic-detoxicant preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, CUIYUNCAO, Herba Patriniae, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati, Flos Chrysanthemi Indici are pulverized and sieved together with step (1) (2) (3) made crude drug, make medicated powder, made medicated powder is (preferred according to the metering of 0.25-0.35g/ sheet, according to the metering of 0.30g/ sheet), suppress conglobate tablet dosage form according to the preparation for processing of tablet.
8. the preparation method of the typhlitic antipyretic-detoxicant preparation tablet for the treatment of as claimed in claim 7, is characterized in that, step (4) was pulverized 90-200 mesh sieve and (preferably, pulverized 120-170 mesh sieve; Be more preferably, pulverized 150 mesh sieves).
9. the typhlitic antipyretic-detoxicant preparation for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable soft extract, its preparation method is:
(1) extracting liquorice section, decocts soup, and adding clean Rhizoma Paridis with boiling, treating that decoction exhausts, take out, section, dries;
(2) by Rhizoma Curcumae decontamination, clean, with Fructus Crotonis with boiling, well-done rear taking-up, with the face block parcel of becoming reconciled, be then placed in hot ash and simmer to well-done, take out, the face block of removing outside parcel, dries;
(3) Herba Bidentis Bipinnatae is picked clean impurity, put into frying pan, moderate heat heats, and fries to surface coke brown, spray rice vinegar, and go out most Mars, closes fire and adds a cover, stew to moisten, take out, dry;
(4) Herba stellariae mediae, Cortex Magnoliae Officinalis, Herba Ixeritis Sonchifoliae, Herba Patriniae, CUIYUNCAO, Herba Lobeliae Chinensis, Radix Rehmanniae, Fructus Seu Herba Pubescentis, Herba Taraxaci, Herba Adianti Flabellulati and Flos Chrysanthemi Indici are cleaned, non iron container is put into together with step (1) (2) (3) made crude drug, soak 26 minutes, big fire is heated to boiling, be adjusted to little fire decoct 20-30 minute (preferred, be adjusted to little fire and decoct 22-28 minute; Be more preferably, be adjusted to little fire and decoct 25 minutes), then filter, filtering residue adds water and again decocts, and filters, merges twice gained filtrate, and heating is condensed into paste, adds refined honey and stirs evenly, obtain soft extract.
10. the preparation method of the typhlitic antipyretic-detoxicant preparation soft extract for the treatment of as claimed in claim 9, is characterized in that, step (4) twice amount of water is the 7-9 of crude drug gross mass doubly (preferred, twice amount of water is 8 times of crude drug gross mass).
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| CN106511632A (en) * | 2016-12-12 | 2017-03-22 | 徐洪安 | Medicine for treating appendicitis and preparation method of medicine |
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