CN104758620A - Liver-soothing and bladder-relieving agent for patients with cholecystitis and preparation method of liver-soothing and bladder-relieving agent - Google Patents
Liver-soothing and bladder-relieving agent for patients with cholecystitis and preparation method of liver-soothing and bladder-relieving agent Download PDFInfo
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Abstract
The invention discloses a liver-soothing and bladder-relieving agent for patients with cholecystitis. The liver-soothing and bladder-relieving agent is mainly prepared from the following raw materials in parts by mass: 13-20 parts of lily, 9-15 parts of jamaica vervain, 6-15 parts of cleisostoma scolopendrifolium, 12-18 parts of homonoia riparia lour, 9-13 parts of diploclisia glaucescens, 7-13 parts of nauclea officinalis pierre ex petard, 9-15 parts of endothelium corneum gigeriae galli, 10-13 parts of flos mume, 11-17 parts of hungaian morning glory roots, 8-13 parts of japanese apricot roots, 12-16 parts of arenaria kansuensis, 9-16 parts of panax notoginseng, 12-16 parts of dandelion, 11-16 parts of solanum lyratum thumb, 8-15 parts of semen raphani and 13-16 parts of atractylodes. The liver-soothing and bladder-relieving agent is low in preparation cost, significant in curative effect and free of an obvious toxic or side effect; the composition completely conforms to the principle of the traditional Chinese medicine, has the efficacy of clearing heat, removing dampness, relieving bladder, diminishing inflammation, removing calculi and removing urinary calculus, is capable of treating both symptoms and root causes of cholecystitis, is suitable for acute and chronic cholecystitis, and is also capable of enhancing the organism immunity.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the agent of a kind of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting and preparation method.
Background technology
Cholecystitis is the gallbladder inflammatory lesion that bacterial infection or chemical irritation (bile component change) cause, and is the commonly encountered diseases of gallbladder.In abdominal surgery, its sickness rate is only second to appendicitis, and primary disease is more common in the middle age of 35 ~ 55 years old, and the women comparatively male that falls ill for many, is more common in obesity and the women of multiple pregnancies especially.People in middle age, operating pressure is large, spirit is relatively nervous, health is also being got fat etc., these factors cause having increase and easily cause having neuroregulation in various degree and dysbolismus, affect normal contraction and the diastole of gallbladder, make the excretion of bile obstructed, cause fat metabolic disturbance, cholesterol deposits, easy formation cholelithiasis, is easy to bring out cholecystitis.Cholecystitis divides acute and chronic two kinds, acute cholecystitis morbidity with cholestasis and bacteriological infection closely related.Main Pathogenic Bacteria is the gram-negative bacterias such as escherichia coli (accounting for 60% ~ 70%), klebsiella, anaerobic bacillus(cillus anaerobicus), and how being driven in the wrong direction through common bile duct by intestinal enters gallbladder, and minority trans-portal vein system is to liver, flow into gallbladder with bile again.Chronic cholecystitis a part of the delay for acute cholecystitis forms, but most the past there is no acute attack history.The symptom and sign of acute cholecystitis is, many patients fall ill after midnight in the greasy dinner of oil-feed, because high fat diet can make gallbladder strengthen shrinking, and flat sleeping be easy to little cholelithiasis and slip into and incarceration cystic duct.Main manifestations is right upper quadrant rest pain, paroxysmal aggravation, can take on back of the body radiation to the right; Often occur together heat, nausea and vomiting, but it is rare to shiver with cold, and jaundice is light.Abdomen examination finds that upper right abdomen is full, gallbladder area tension of abdominal muscle, obviously tenderness, rebound tenderness.Symptom, the sign of chronic cholecystitis are not true to type.Majority shows as bile peretinitis dyspepsia, detests greasy food, epigastrium vexed swollen, belch, scorching hot etc., is similar to Peptic Ulcers or chronic appendicitis; Sometimes because of Stone obstruction cystic duct, can be acute attack, but when calculus moves, blocks releasing, namely take a turn for the better rapidly.Body is looked into, and can there be mild tenderness or percussion pain in gallbladder area; If gallbladder hydrops, often can lay one's hand on and circular, smooth cystic mass.Western medicine cholecystitis gives spasmolytic, analgesia therapy more, and in conjunction with antibacterial therapy.The dialectical treatment of the traditional Chinese medical science many employings soothing liver-QI, function of gallbladder promoting.
Publication No. CN 103263516 A(application number 201310209982.0) Chinese patent literature disclose a kind of medicine for the treatment of cholecystitis, raw material has Radix Notoginseng 10 ~ 30, Fructus Crataegi 10 ~ 20, Pericarpium Citri Reticulatae 10 ~ 25, Flos Caryophylli 10 ~ 25, Radix Bupleuri 15 ~ 35, the Radix Paeoniae Alba 15 ~ 35, Fructus Aurantii 20 ~ 35, the Radix Aucklandiae 10 ~ 20, Fructus Toosendan 10 ~ 20, Herba Artemisiae Scopariae 6 ~ 15, Herba Lysimachiae 20 ~ 35, Radix Glycyrrhizae 3 ~ 10.Publication No. CN 104189163 A(application number 201410414160.0) Chinese patent literature disclose a kind of Chinese medicine formula for the treatment of cholecystitis, crude drug comprises Radix Bupleuri 12-17 part, Radix Gentianae 12-17 part, Fructus Gardeniae 18-22 part, Radix Scutellariae 18-22 part, Herba Artemisiae Scopariae 22-28 part.Publication No. CN 104367968 A(application number 201310353217.6) Chinese patent literature disclose a kind of combination of Chinese medicine for the treatment of cholecystitis, be made up of Radix Bupleuri, Radix Et Rhizoma Rhei, the Radix Paeoniae Alba, Rhizoma Corydalis, Radix Scutellariae, Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Radix Curcumae, the Radix Aucklandiae.
The Chinese medicine for the treatment of cholecystitis has many, but some is only cured the symptoms, not the disease, and easily causes the state of an illness repeatedly, therefore in the urgent need to developing for primary disease, and the medicine for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, curative effect reliable, take safe cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent and preparation method.
Technical scheme of the present invention is:
The agent of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting, is prepared from primarily of following bulk drugs, is mass parts: Bulbus Lilii 13-20, Herba Stachytarphetae Jamaicensis 9-15, Herba Cleisostomatis scolopendrifolii 6-15, Radix Homonoiae Ripariae 12-18, Caulis Diploclisiae Glaucescentis 9-13, Lignum et Radix Naucleae 7-13, Endothelium Corneum Gigeriae Galli 9-15, FLOS MUME 10-13, Ipomoea hungaiensis Lingelsh. Et Borza. 11-17, Radix Mume 8-13, Herba arenariae kansuensis 12-16, Radix Notoginseng 9-16, Herba Taraxaci 12-16, Herba Solani Lyrati 11-16, Semen Raphani 8-15, Rhizoma Atractylodis 13-16.
In preferred scheme, Bulbus Lilii 15-18, Herba Stachytarphetae Jamaicensis 10-14, Herba Cleisostomatis scolopendrifolii 8-13, Radix Homonoiae Ripariae 14-16, Caulis Diploclisiae Glaucescentis 10-12, Lignum et Radix Naucleae 9-11, Endothelium Corneum Gigeriae Galli 11-13, FLOS MUME 11-12, Ipomoea hungaiensis Lingelsh. Et Borza. 13-15, Radix Mume 9-12, Herba arenariae kansuensis 13-15, Radix Notoginseng 11-14, Herba Taraxaci 13-15, Herba Solani Lyrati 12-15, Semen Raphani 10-13, Rhizoma Atractylodis 14-15.
Be more preferably, Bulbus Lilii 16.5, Herba Stachytarphetae Jamaicensis 12, Herba Cleisostomatis scolopendrifolii 10.5, Radix Homonoiae Ripariae 15, Caulis Diploclisiae Glaucescentis 11, Lignum et Radix Naucleae 10, Endothelium Corneum Gigeriae Galli 12, FLOS MUME 11.5, Ipomoea hungaiensis Lingelsh. Et Borza. 14, Radix Mume 10.5, Herba arenariae kansuensis 14, Radix Notoginseng 12.5, Herba Taraxaci 14, Herba Solani Lyrati 13.5, Semen Raphani 11.5, Rhizoma Atractylodis 14.5.
Described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, wash quickly is clean, non iron container is put into together with step (1) (2) made crude drug, after soaking 20 minutes, heating decocts, big fire is boiled to boiling, and little fire decocts 25-45 minute, and (preferred, 30-40 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 35 minutes), filter, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) join in step (4) made filtrate by step (3) made medicated powder, mixing, obtains decoction.
The preparation method of described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent decoction, step (4) amount of water is the 7-9 of total raw material medicine quality doubly (preferred, amount of water is 8 times of total raw material medicine quality).
Described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, clean, put into steamer, Steam by water bath 30 minutes, takes out, dries in the air cool, dry, pulverize and sieve together with step (1) (2) made crude drug, and mix with step (3) made medicated powder, obtain powder.
The preparation method of described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent powder, step (4) was pulverized 130-200 mesh sieve and (preferably, was pulverized 150-180 mesh sieve; Be more preferably, pulverized 160 mesh sieves).
Described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained Endothelium Corneum Gigeriae Galli powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, clean, put into steamer, after Steam by water bath, take out, dry in the air cool, dry, pulverized 80-140 mesh sieve and (preferably, pulverized 100-130 mesh sieve together with step (1) (2) made crude drug; Be more preferably, pulverized 120 mesh sieves), make medicated powder;
(5) by step (3) and (4) made Endothelium Corneum Gigeriae Galli powder and medicated powder mixing, add vinegar, generally make ball, obtained pill.
The preparation method of described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent tablet, step (4) Steam by water bath 20-40 minute (preferred, Steam by water bath 25-35 minute; Be more preferably, Steam by water bath 30 minutes).
Described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, wash quickly is clean, non iron container is put into together with step (1) (2) made crude drug, the soak by water of totalling crude drug quality 8 times three times, each big fire is boiled to boiling, turns little fire and decocts, filter, collect filtrate, merge three gained filtrates;
(5) join in step (4) made filtrate by step (3) made medicated powder, mixing, concentrating under reduced pressure, spraying dry, mixes with pharmaceutical excipients, and obtained granule, incapsulates, obtain capsule.
The preparation method of described cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent capsules agent, step (4) turn little fire decocts 25-45 minute, and (preferred, 30-40 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 35 minutes).
Cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, cost of manufacture of the present invention low, evident in efficacy, without obvious toxic-side effects;
2, this prescription meets Chinese medicine principle completely, has the effects such as clearing away heat-damp and promoting diuresis, cholagogue and eliminating inflammation, change knot calculus;
3, this prescription can treating both the principal and secondary aspects of a disease to cholecystitis, is applicable to acute and chronic cholecystitis, also can enhancing human body immunity power.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the agent of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting, is prepared from (every part of 10g) primarily of following bulk drugs: Bulbus Lilii 13 parts, Herba Stachytarphetae Jamaicensis 9 parts, Herba Cleisostomatis scolopendrifolii 6 parts, Radix Homonoiae Ripariae 12 parts, Caulis Diploclisiae Glaucescentis 9 parts, Lignum et Radix Naucleae 7 parts, Endothelium Corneum Gigeriae Galli 9 parts, FLOS MUME 10 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 11 parts, Radix Mume 8 parts, Herba arenariae kansuensis 12 parts, Radix Notoginseng 9 parts, Herba Taraxaci 12 parts, Herba Solani Lyrati 11 parts, Semen Raphani 8 parts, Rhizoma Atractylodis 13 parts.
The preparation method of above-mentioned cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent decoction is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, wash quickly is clean, put into non iron container together with step (1) (2) made crude drug, add up the water soaking of crude drug quality 8 times after 20 minutes, heating decocts, big fire is boiled to boiling, little fire decocts 35 minutes, filters, and collects filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) join in step (4) made filtrate by step (3) made medicated powder, mixing, obtains decoction.
embodiment 2the agent of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting, is prepared from (every part of 10g) primarily of following bulk drugs: Bulbus Lilii 20 parts, Herba Stachytarphetae Jamaicensis 15 parts, Herba Cleisostomatis scolopendrifolii 15 parts, Radix Homonoiae Ripariae 18 parts, Caulis Diploclisiae Glaucescentis 13 parts, Lignum et Radix Naucleae 13 parts, Endothelium Corneum Gigeriae Galli 15 parts, FLOS MUME 13 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 17 parts, Radix Mume 13 parts, Herba arenariae kansuensis 16 parts, Radix Notoginseng 16 parts, Herba Taraxaci 16 parts, Herba Solani Lyrati 16 parts, Semen Raphani 15 parts, Rhizoma Atractylodis 16 parts.
The preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent powder is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, clean, put into steamer, Steam by water bath 30 minutes, takes out, dries in the air cool, dry, pulverize 160 mesh sieves together with step (1) (2) made crude drug, and mixed with step (3) made medicated powder, obtain powder.
Model case: xxx, female, 48 years old.Main suit: the indistinct distending pain of upper abdomen before three days, after gradually become paroxysmal colic, pain is radiated to right shoulder and omoplate, self-induction Nausea and vomiting, without appetite, constipation with dry stool, medical check, low grade fever 37.5 DEG C, upper right abdomen has obvious tenderness, red tongue with yellow fur, and total white blood cells and neutrophil cell number raise, B ultrasonic display gollbladder dilation, cyst wall is fuzzy, crude, is diagnosed as acute cholecystitis.
Take the present embodiment gained cholecystitis depressed liver-energy dispersing and function of gallbladder promoting agent powder, every day 2 times, each 6-8g, warm boiled water, 15 days courses for the treatment of.After taking one day, temperature recovery is normal, and after taking 6 days, nausea and vomiting etc. are uncomfortable to be eliminated, and appetite is recovered, and after taking a course for the treatment of, patient is symptom invariably, and self-induction is fully recovered, check, and normally, patient fully recovers, and follows up a case by regular visits in two years, does not recur for total white blood cells and gallbladder.
embodiment 3the agent of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting, is prepared from (every part of 10g) primarily of following bulk drugs: Bulbus Lilii 15 parts, Herba Stachytarphetae Jamaicensis 10 parts, Herba Cleisostomatis scolopendrifolii 8 parts, Radix Homonoiae Ripariae 14 parts, Caulis Diploclisiae Glaucescentis 10 parts, Lignum et Radix Naucleae 9 parts, Endothelium Corneum Gigeriae Galli 11 parts, FLOS MUME 11 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 13 parts, Radix Mume 9 parts, Herba arenariae kansuensis 13 parts, Radix Notoginseng 11 parts, Herba Taraxaci 13 parts, Herba Solani Lyrati 12 parts, Semen Raphani 10 parts, Rhizoma Atractylodis 14 parts.
The preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent pill is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained Endothelium Corneum Gigeriae Galli powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, clean, put into steamer, Steam by water bath is after 30 minutes, take out, dry in the air cool, dry, pulverize 120 mesh sieves together with step (1) (2) made crude drug, make medicated powder;
(5) by step (3) and (4) made Endothelium Corneum Gigeriae Galli powder and medicated powder mixing, add vinegar, generally make ball, obtained pill.
Model case: xxx, man, 40 years old.Right flank pain is more than 4 years, time when doing only, be diagnosed as chronic cholecystitis through ultrasound diagnosis, take XIAOYAN LIDAN PIAN, JINDAN PIAN etc., therapeutic effect is not obvious, the indistinct paroxysmal pain of right flank, after edible oil deep-fried food, pain increases the weight of, irritable, dry mouth and tougue, anorexia, sleeps poor, large dry stool; oliguria with reddish urine, red tongue, thin fur; the trickle number of stringy pulse, asks about skilful doctor's formula everywhere.
After learn the present invention, then take the present embodiment gained cholecystitis depressed liver-energy dispersing and function of gallbladder promoting agent pill, adopt twice daily, each 4-6 ball, with warm water delivery service, 15 days courses for the treatment of.After taking 3 days, the malaise symptoms such as appetite, sleep and xerostomia are all clearly better, and after taking one week, each malaise symptoms disappears substantially, after taking a course for the treatment of, right flank pain disappears, and consolidates and takes a course for the treatment of, check, gallbladder is normal, and patient fully recovers, and follow up a case by regular visits in 1 year, patient is not recurred.
embodiment 4the agent of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting, is prepared from (every part of 10g) primarily of following bulk drugs: Bulbus Lilii 18 parts, Herba Stachytarphetae Jamaicensis 14 parts, Herba Cleisostomatis scolopendrifolii 13 parts, Radix Homonoiae Ripariae 16 parts, Caulis Diploclisiae Glaucescentis 12 parts, Lignum et Radix Naucleae 11 parts, Endothelium Corneum Gigeriae Galli 13 parts, FLOS MUME 12 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 15 parts, Radix Mume 12 parts, Herba arenariae kansuensis 15 parts, Radix Notoginseng 14 parts, Herba Taraxaci 15 parts, Herba Solani Lyrati 15 parts, Semen Raphani 13 parts, Rhizoma Atractylodis 15 parts.
The preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent capsules agent is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, wash quickly is clean, non iron container is put into together with step (1) (2) made crude drug, the soak by water of totalling crude drug quality 8 times three times, each big fire is boiled to boiling, turns little fire and decocts 35 minutes, filter, collect filtrate, merge three gained filtrates;
(5) join in step (4) made filtrate by step (3) made medicated powder, mixing, concentrating under reduced pressure, spraying dry, mixes with pharmaceutical excipients, and obtained granule, incapsulates, obtain capsule.
Model case: xxx, female, 43 years old.Right distending pain in the hypochondrium recurrent exerbation 2 years, within nearly one week, have a rest bad, right distending pain in the hypochondrium increases the weight of, and being radiated to right pain in the shoulder and back, gastral cavity abdomen is vexed swollen, feels sick indigestion and loss of appetite, detest greasy food, tired, bitter taste xerostomia, medical check, low grade fever 37.6 DEG C, red tongue, the micro-Huang of tongue is greasy, stringy and rolling pulse, B ultrasonic display gollbladder dilation, cyst wall thickens, crude, be diagnosed as chronic cholecystitis.
Take the agent of the present embodiment gained cholecystitis depressed liver-energy dispersing and function of gallbladder promoting agent capsules, adopt twice daily, each 4, with warm water delivery service, 15 days courses for the treatment of.After taking one week, all diseases are clearly better, and pain obviously alleviates, and after taking a course for the treatment of, all diseases disappear substantially, consolidate and take one week, check, and gallbladder is normal, and patient fully recovers, and follow up a case by regular visits in two years, the state of an illness is not more repeatedly.
embodiment 5the agent of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting, is prepared from (every part of 10g) primarily of following bulk drugs: Bulbus Lilii 16.5 parts, Herba Stachytarphetae Jamaicensis 12 parts, Herba Cleisostomatis scolopendrifolii 10.5 parts, Radix Homonoiae Ripariae 15 parts, Caulis Diploclisiae Glaucescentis 11 parts, Lignum et Radix Naucleae 10 parts, Endothelium Corneum Gigeriae Galli 12 parts, FLOS MUME 11.5 parts, Ipomoea hungaiensis Lingelsh. Et Borza. 14 parts, Radix Mume 10.5 parts, Herba arenariae kansuensis 14 parts, Radix Notoginseng 12.5 parts, Herba Taraxaci 14 parts, Herba Solani Lyrati 13.5 parts, Semen Raphani 11.5 parts, Rhizoma Atractylodis 14.5 parts.
The preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent decoction is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, wash quickly is clean, put into non iron container together with step (1) (2) made crude drug, add up the water soaking of crude drug quality 8 times after 20 minutes, heating decocts, big fire is boiled to boiling, little fire decocts 35 minutes, filters, and collects filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) join in step (4) made filtrate by step (3) made medicated powder, mixing, obtains decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Bulbus Lilii: base is former: be liliaceous plant Bulbus Lilii, Lilium tenuifolium, Lilium longiflorum and the scale leaf belonging to various plants bulb together thereof.Nature and flavor: sweet, cold.Gui Jing: GUIXIN, lung meridian.Function cures mainly: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Herba Stachytarphetae Jamaicensis: base is former: be herb or the root of the false Herba Patriniae of Verbenaceae.Nature and flavor: sweet, bitter, cold.Function cures mainly: dampness removing blood stasis dispelling, heat-clearing and toxic substances removing.Control gonorrhea, nebulousurine, rheumatic arthralgia, conjunctivitis, laryngitis, traumatic injury congestive edema, carbuncle furuncle.
Herba Cleisostomatis scolopendrifolii: base is former: be the herb of orchid Herba Cleisostomatis scolopendrifolii.Nature and flavor: micro-hardship are cool.Function cures mainly: heat-clearing and toxic substances removing, and lung moistening is stopped blooding.For tracheitis, spitting of blood, cholecystitis, pharyngolaryngitis, acute tonsillitis, chronic paranasal rhinitis, pyelonephritis, infantile convulsion.
Radix Homonoiae Ripariae: base is former: be the root of euphorbia plant water willow.Nature and flavor: bitter, cold.Gui Jing: liver, gallbladder, urinary bladder channel.Function cures mainly: heat clearing away, function of gallbladder promoting, diuresis, removing toxic substances.Main acute, chronic hepatitis, cholecystitis, cholelithiasis, vesical calculus, gonorrhea, syphilis, hemorrhoid, traumatic injury, scalds.
Caulis Diploclisiae Glaucescentis: base is former: be the rattan of menispermaceae plant Caulis Diploclisiae Glaucescentis.Nature and flavor: micro-hardship, cold.Gui Jing: liver, spleen, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness.Main rheumatic ostalgia, laryngopharynx swelling and pain, cholecystitis, dysentery, urinary tract infection, venom.
Lignum et Radix Naucleae: base is former: be branch, the bark of Maguireothamnus speciosus Lignum et Radix Naucleae.Nature and flavor: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For cold, fever, acute tonsillitis, pharyngolaryngitis, bronchitis, pneumonia, urinary system infection, enteritis, dysentery, cholecystitis; Mastitis are controlled in external, carbuncle furuncle abscess.
Endothelium Corneum Gigeriae Galli: base is former: be the dry gizzard tunica intima of Phasianidae animal man chicken.Nature and flavor: sweet are flat.Gui Jing: enter spleen, stomach warp.Function cures mainly: removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
FLOS MUME: base is former: the flower of Armeniaca Mume of Rosaceae platymiscium FLOS MUME.Nature and flavor: bitter, micro-sweet are flat.Function cures mainly: dispersing the stagnated live-QI to relieve the stagnation of QI, and appetizing rises Tianjin.For uncomfortable in chestly not relax, anorexia and globus hystericus.
Ipomoea hungaiensis Lingelsh. Et Borza.: base is former: be the tuber of convolvulaceous plant Ipomoea hungaiensis Lingelsh. Et Borza..Nature and flavor: sweet are flat.Gui Jing: enter spleen, stomach warp.Function cures mainly: liver heat removing function of gallbladder promoting, nourishing the lung to arrest cough.Harness the Yellow River subcutaneous ulcer, chronic hepatitis, cough due to lung-heat, hematochezia, breast is few, leukorrhagia, infantile malnutrition.
Radix Mume: base is former: be the root of rose department plant plum.Nature and flavor: micro-hardship, is slightly cold.Gui Jing: liver, gallbladder meridian.Function cures mainly: expelling wind and removing dampness, heat-clearing and toxic substances removing.Main air numbness, chronic dysentery with frequent relapse, cholecystitis, scrofula.
Herba arenariae kansuensis: base is former: be the herb of pinkwort Gansu sandwort.Nature and flavor: sweet, cold.Function cures mainly: nourishing YIN and benefiting blood, invigorating function of kidney and strengthening bone.For xeropulmonary cough, hemoptysis, blood deficiency migratory arthralgia, bones and muscles pain, dizziness due to deficiency of the kidney.
Radix Notoginseng: base is former: be the root of araliad Panax pseudoginseng.Nature and flavor: sweet, micro-, bitter, temperature.Gui Jing: enter liver, stomach, large intestine channel.Function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.
Herba Taraxaci: base is former: be the whole herb with root of feverfew Herba Taraxaci.Nature and flavor: bitter, sweet, cold.Gui Jing: enter liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Herba Solani Lyrati: base is former: be the herb of plant of Solanaceae Herba Solani Lyrati.Nature and flavor: sweet, bitter, cold.Gui Jing: return liver, gallbladder, kidney channel.Function cures mainly: heat clearing away, and dampness removing dispels the wind, removing toxic substances.Treating malaria disease, jaundice, edema, gonorrhea, rheumatic arthritis, erysipelas, furuncle.
Semen Raphani: base is former: be the mature seed of crucifer Radix Raphani.Nature and flavor: pungent, sweet are flat.Gui Jing: return lung, spleen, stomach warp.Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Rhizoma Atractylodis: base is former: be the rhizome of feverfew RHIZOMA ATRACTYLODIS IANCEAE or Atractylis chinensis etc.Nature and flavor: pungent, bitter, temperature.Gui Jing: return spleen, stomach, Liver Channel.Function cures mainly: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
test example 1the clinical practice of gained cholecystitis depressed liver-energy dispersing and function of gallbladder promoting of the present invention agent (embodiment 5):
In January, 2013 in December ,-2014,426 routine patients are screened in 4 hospitals, wherein women 235 example, male 191 example, age 20-62 year, 43.8 ± 4.2 years old mean age, wherein acute cholecystitis patient 169 example, course of disease 1-12 days, chronic cholecystitis patient 257 example, with cholelithiasis person 62 example, course of disease 1.2-10.Diagnostic criteria: the symptoms such as nausea and vomiting, pantothenic acid, abdominal distention, heating, constipation and lack of appetite poor appetite can be occurred, the postemphasis of general feed greasy food, right upper quadrant of the abdomen gallbladder area tenderness, percussion pain and muscle tonus, some patients can be laid one's hand on and enlargement gallbladder, with slight jaundice, and red tongue, yellow and greasy fur, wiry and frequent pulse or sliding number, blood routine examination total white blood cells raises, and gallbladder wall is crude thickens in B ultrasonic display, gallbladder reduces or is out of shape, the visible cholelithiasis of some patients.
Patient is divided into two groups at random, experimental group 244 example and matched group 182 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, take every day twice (warm), each 300m1-350m1(adjusts to some extent depending on concrete condition), 15 days courses for the treatment of, matched group takes other medicine (conventional medication such as osalmid capsules, DANSHU JIAONANG, armillarisin A tablets).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.Add up acute cholecystitis patient treatment situation after the course for the treatment of, after two courses for the treatment of, add up chronic cholecystitis patient treatment situation.Total effective rate=(curing number of cases+effective number of cases+effectively number of cases)/total number of cases × 100%
Curative effect situation criterion: cure: clinical symptoms, sign all disappear, and ultrasound diagnosis calculus is all discharged, gallbladder function recovers normal, inflammatory resolution, and blood routine examination is normal; Effective: clinical symptoms, sign obviously alleviate, attack times reduces, and ultrasound diagnosis calculus volume-diminished is more than 0.5cm
3or quantity reduces by more than 1/3, gall-bladder wall thickness obviously improves, and inflammation takes a turn for the better, and blood routine examination is normal; Effective: clinical symptoms, sign are alleviated to some extent, attack times reduces, and ultrasound diagnosis calculus volume-diminished is more than 0.2cm
3or quantity reduces less than 1/3, have improvements in thickening of capsule wall of gallbladder, crude, entrant sound, inflammation improvement, blood routine examination is normal; Invalid: clinical symptoms and sign without improvement, blood routine examination, B ultrasonic display gallbladder wall and calculus number and volume all unchanged.Result is as shown in table 1.
Table 1 liang group patient treatment outcome
Relatively two groups of patient treatment outcome's (result sees table 1), the total effective rate of experimental group patient treatment is 98.4%, and the total effective rate of matched group patient treatment is 79.1%, and the therapeutic effect of visible experimental group is obviously better than matched group.Improve situation (table 2) from two groups of patients symptomatic, the entirety of experimental group patients symptomatic and sign is improved situation and is obviously better than matched group.Illustrate that products made thereby of the present invention effectively can alleviate clinical symptoms and the sign of cholecystitis.
The improvement situation (improving the front uncomfortable number of cases of number of cases/improvement) of table 2 liang group patient clinical symptom and sign
The Bulbus Lilii of nourishing YIN and moistening the lung is had, the Herba Stachytarphetae Jamaicensis of dampness removing blood stasis dispelling, the Herba Cleisostomatis scolopendrifolii of heat-clearing and toxic substances removing, Caulis Diploclisiae Glaucescentis, Radix Mume and Herba Taraxaci in formula of the present invention, the Lignum et Radix Naucleae of reducing swelling and alleviating pain, removing food stagnancy is stagnant, the Endothelium Corneum Gigeriae Galli of strengthening the spleen and stomach, the FLOS MUME of dispersing the stagnated live-QI to relieve the stagnation of QI, the Ipomoea hungaiensis Lingelsh. Et Borza. of liver heat removing function of gallbladder promoting, the Herba arenariae kansuensis of promoting the function of the gallbladder to alleviate jaundice, the Radix Notoginseng of subduing swelling and relieving pain, the Herba Solani Lyrati of clearing away heat-damp and promoting diuresis, the Semen Raphani of lowering the adverse-rising QI to resolve phlegm, drying damp and strengthening spleen Rhizoma Atractylodis, the coupling of multiple effective material, plays the effects such as clearing away heat-damp and promoting diuresis, cholagogue and eliminating inflammation, change knot calculus altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. the agent of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting, is characterized in that, is prepared from primarily of following bulk drugs, is mass parts: Bulbus Lilii 13-20, Herba Stachytarphetae Jamaicensis 9-15, Herba Cleisostomatis scolopendrifolii 6-15, Radix Homonoiae Ripariae 12-18, Caulis Diploclisiae Glaucescentis 9-13, Lignum et Radix Naucleae 7-13, Endothelium Corneum Gigeriae Galli 9-15, FLOS MUME 10-13, Ipomoea hungaiensis Lingelsh. Et Borza. 11-17, Radix Mume 8-13, Herba arenariae kansuensis 12-16, Radix Notoginseng 9-16, Herba Taraxaci 12-16, Herba Solani Lyrati 11-16, Semen Raphani 8-15, Rhizoma Atractylodis 13-16.
2. cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent as claimed in claim 1, it is characterized in that, Bulbus Lilii 15-18, Herba Stachytarphetae Jamaicensis 10-14, Herba Cleisostomatis scolopendrifolii 8-13, Radix Homonoiae Ripariae 14-16, Caulis Diploclisiae Glaucescentis 10-12, Lignum et Radix Naucleae 9-11, Endothelium Corneum Gigeriae Galli 11-13, FLOS MUME 11-12, Ipomoea hungaiensis Lingelsh. Et Borza. 13-15, Radix Mume 9-12, Herba arenariae kansuensis 13-15, Radix Notoginseng 11-14, Herba Taraxaci 13-15, Herba Solani Lyrati 12-15, Semen Raphani 10-13, Rhizoma Atractylodis 14-15 is (preferred, Bulbus Lilii 16.5, Herba Stachytarphetae Jamaicensis 12, Herba Cleisostomatis scolopendrifolii 10.5, Radix Homonoiae Ripariae 15, Caulis Diploclisiae Glaucescentis 11, Lignum et Radix Naucleae 10, Endothelium Corneum Gigeriae Galli 12, FLOS MUME 11.5, Ipomoea hungaiensis Lingelsh. Et Borza. 14, Radix Mume 10.5, Herba arenariae kansuensis 14, Radix Notoginseng 12.5, Herba Taraxaci 14, Herba Solani Lyrati 13.5, Semen Raphani 11.5, Rhizoma Atractylodis 14.5).
3. the cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, wash quickly is clean, non iron container is put into together with step (1) (2) made crude drug, after soaking 20 minutes, heating decocts, big fire is boiled to boiling, and little fire decocts 25-45 minute, and (preferred, 30-40 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 35 minutes), filter, collect filtrate, filtering residue adds water and again decocts, and merges twice gained filtrate;
(5) join in step (4) made filtrate by step (3) made medicated powder, mixing, obtains decoction.
4. the preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent decoction as claimed in claim 3, is characterized in that, step (4) amount of water is the 7-9 of total raw material medicine quality doubly (preferred, amount of water is 8 times of total raw material medicine quality).
5. the cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, clean, put into steamer, Steam by water bath 30 minutes, takes out, dries in the air cool, dry, pulverize and sieve together with step (1) (2) made crude drug, and mix with step (3) made medicated powder, obtain powder.
6. the preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent powder as claimed in claim 5, is characterized in that, step (4) was pulverized 130-200 mesh sieve and (preferably, pulverized 150-180 mesh sieve; Be more preferably, pulverized 160 mesh sieves).
7. the cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable pill, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained Endothelium Corneum Gigeriae Galli powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, clean, put into steamer, after Steam by water bath, take out, dry in the air cool, dry, pulverized 80-140 mesh sieve and (preferably, pulverized 100-130 mesh sieve together with step (1) (2) made crude drug; Be more preferably, pulverized 120 mesh sieves), make medicated powder;
(5) by step (3) and (4) made Endothelium Corneum Gigeriae Galli powder and medicated powder mixing, add vinegar, generally make ball, obtained pill.
8. the preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent tablet as claimed in claim 7, is characterized in that, step (4) Steam by water bath 20-40 minute (preferred, Steam by water bath 25-35 minute; Be more preferably, Steam by water bath 30 minutes).
9. the cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Lignum et Radix Naucleae removing impurity, wash quickly is clean, and with steeping in wine one night, take out, put into frying pan, when moderate heat is fried to surperficial pitchy, take out, spray clear water, go out most Mars, takes out, spread out, dry in the air cool;
(2) get Rhizoma Atractylodis remove impurity, saturating with Oryza sativa L. var. glutinosa Matsum. blister to eighty per cant, clean, scrape peeling, section, mixes thoroughly with Mel and wine, puts into steamer, and Steam by water bath is saturating, takes out, dries;
(3) Endothelium Corneum Gigeriae Galli is cleaned, crush, mix thoroughly with Fel Sus domestica, putting into the heating of frying pan slow fire, frying to heaving, take out, dry, pulverize, obtained medicated powder;
(4) by Bulbus Lilii, Herba Stachytarphetae Jamaicensis, Herba Cleisostomatis scolopendrifolii, Radix Homonoiae Ripariae, Caulis Diploclisiae Glaucescentis, FLOS MUME, Ipomoea hungaiensis Lingelsh. Et Borza., Radix Mume, Herba arenariae kansuensis, Radix Notoginseng, Herba Taraxaci, Herba Solani Lyrati and Semen Raphani removing impurity, wash quickly is clean, non iron container is put into together with step (1) (2) made crude drug, the soak by water of totalling crude drug quality 8 times three times, each big fire is boiled to boiling, turns little fire and decocts, filter, collect filtrate, merge three gained filtrates;
(5) join in step (4) made filtrate by step (3) made medicated powder, mixing, concentrating under reduced pressure, spraying dry, mixes with pharmaceutical excipients, and obtained granule, incapsulates, obtain capsule.
10. the preparation method of cholecystitis's depressed liver-energy dispersing and function of gallbladder promoting agent capsules agent as claimed in claim 9, is characterized in that, step (4) turn little fire decocts 25-45 minute, and (preferred, 30-40 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 35 minutes).
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| CN106728803A (en) * | 2016-12-28 | 2017-05-31 | 陕西红顶名医堂药业有限公司 | For treating chronic cholecystitis, the Chinese medicine composition of cholelithiasis and preparation method |
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